SCIENTIFIC PROGRAM Table of Contents
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Acral Compound Nevus SJ Yun S Korea
University of Pennsylvania, Founded by Ben Franklin in 1740 Disclosures Consultant for Myriad Genetics and for SciBase (might try to sell you a book, as well) Multidimensional Pathway Classification of Melanocytic Tumors WHO 4th Edition, 2018 Epidemiologic, Clinical, Histologic and Genomic Aspects of Melanoma David E. Elder, MB ChB, FRCPA University of Pennsylvania, Philadelphia, PA, USA Napa, May, 2018 3rd Edition, 2006 Malignant Melanoma • A malignant tumor of melanocytes • Not all melanomas are the same – variation in: – Epidemiology – risk factors, populations – Cell/Site of origin – Precursors – Clinical morphology – Microscopic morphology – Simulants – Genomic abnormalities Incidence of Melanoma D.M. Parkin et al. CSD/Site-Related Classification • Bastian’s CSD/Site-Related Classification (Taxonomy) of Melanoma – “The guiding principles for distinguishing taxa are genetic alterations that arise early during progression; clinical or histologic features of the primary tumor; characteristics of the host, such as age of onset, ethnicity, and skin type; and the role of environmental factors such as UV radiation.” Bastian 2015 Epithelium associated Site High UV Low UV Glabrous Mucosa Benign Acquired Spitz nevus nevus Atypical Dysplastic Spitz Borderline nevus tumor High Desmopl. Low-CSD Spitzoid Acral Mucosal Malignant CSD melanoma melanoma melanoma melanoma melanoma 105 Point mutations 103 Structural Rearrangements 2018 WHO Classification of Melanoma • Integrates Epidemiologic, Genomic, Clinical and Histopathologic Features • Assists -
Optimal Management of Common Acquired Melanocytic Nevi (Moles): Current Perspectives
Clinical, Cosmetic and Investigational Dermatology Dovepress open access to scientific and medical research Open Access Full Text Article REVIEW Optimal management of common acquired melanocytic nevi (moles): current perspectives Kabir Sardana Abstract: Although common acquired melanocytic nevi are largely benign, they are probably Payal Chakravarty one of the most common indications for cosmetic surgery encountered by dermatologists. With Khushbu Goel recent advances, noninvasive tools can largely determine the potential for malignancy, although they cannot supplant histology. Although surgical shave excision with its myriad modifications Department of Dermatology and STD, Maulana Azad Medical College and has been in vogue for decades, the lack of an adequate histological sample, the largely blind Lok Nayak Hospital, New Delhi, Delhi, nature of the procedure, and the possibility of recurrence are persisting issues. Pigment-specific India lasers were initially used in the Q-switched mode, which was based on the thermal relaxation time of the melanocyte (size 7 µm; 1 µsec), which is not the primary target in melanocytic nevus. The cluster of nevus cells (100 µm) probably lends itself to treatment with a millisecond laser rather than a nanosecond laser. Thus, normal mode pigment-specific lasers and pulsed ablative lasers (CO2/erbium [Er]:yttrium aluminum garnet [YAG]) are more suited to treat acquired melanocytic nevi. The complexities of treating this disorder can be overcome by following a structured approach by using lasers that achieve the appropriate depth to treat the three subtypes of nevi: junctional, compound, and dermal. Thus, junctional nevi respond to Q-switched/normal mode pigment lasers, where for the compound and dermal nevi, pulsed ablative laser (CO2/ Er:YAG) may be needed. -
Seminar ICLAD 2019 Classification of Silicone Foreign Body Reaction.Pdf
SIMPOSIUM Day/ Date: Friday, 26th 2019 Time Schedule Speaker Time Schedule Speaker 07.30- Registration 08.00 Session I: Moderator: David Session II: Wound Moderator: Larisa Fundamentals of Sudarto Oeiria, Dr. Healing in Paramitha Laser & Other Sp.KK, FINSDV, Dermatologic Wibawa, Dr. Sp.KK, Energy Based FAADV Procedure FINSDV Devices: Update 08.00- Biophysics of Laser David Sudarto 08.00- Basic Wound Theresia L. Toruan, 08.20 and Other Energy Oeiria, Dr. Sp.KK, 08.15 Healing in Reducing Sp.KK(K), Prof. Dr. Based Devices FINSDV, FAADV Scar FINSDV, FAADV 08.20- Skin Conditioning Aryani Sudharmono, 08.15- Silicone Gel Usage in M. Akbar 08.40 Regimen for Laser Dr. Sp.KK(K), 08.30 Invasive Wedyadhana, Dr. and Other Energy FINSDV, FAADV Dermatologic Sp.KK, FINSDV Based Devices Procedure Treatment 08.40- Discussion 08.30- Silicone Gel for Yuli Kurniawati, DR. 08.50 08.45 Keloid and Dr. Sp.KK(K), Hypertrophic Scar FINSDV, FAADV 08.45- Discussion 08.50 Time Schedule Speaker Schedule Speaker Plenary Session I Moderator: Made Swastika Adiguna, Prof. Co moderator: Luh Made Mas Rusyati, DR . Dr. Dr. Sp.KK(K), FINSDV, FAADV Sp.KK(K), FINSDV 08.50- To be confirmed To be confirmed 09.10 09.10- Dermatologic Surgery: The History, Present, Lawrence M. Field, Prof. MD 09.40 and Future 09.40- Lillis Tumescent Anesthesia Patrick J. Lilis, MD 10.10 10.10- Discussion 10.20 10.20- Opening Welcome Speech: 10.30 1. Chairman of ICLAD 2.Chairman of PERDOSKI 10.30- Coffee Break 10.45 Sesi III: Stem Cell Moderator: Session IV: Moderator: Made and Growth Factor: Amaranila Lalita Malignancy Wardhana, DR. -
8.5 X12.5 Doublelines.P65
Cambridge University Press 978-0-521-87409-0 - Modern Soft Tissue Pathology: Tumors and Non-Neoplastic Conditions Edited by Markku Miettinen Index More information Index abdominal ependymoma, 744 mucinous cystadenocarcinoma, 631 adult fibrosarcoma (AF), 364–365, 1026 abdominal extrauterine smooth muscle ovarian adenocarcinoma, 72, 79 adult granulosa cell tumor, 523–524 tumors, 79 pancreatic adenocarcinoma, 846 clinical features, 523 abdominal inflammatory myofibroblastic pulmonary adenocarcinoma, 51 genetics, 524 tumors, 297–298 renal adenocarcinoma, 67 pathology, 523–524 abdominal leiomyoma, 467, 477 serous cystadenocarcinoma, 631 adult rhabdomyoma, 548–549 abdominal leiomyosarcoma. See urinary bladder/urogenital tract clinical features, 548 gastrointestinal stromal tumor adenocarcinoma, 72, 401 differential diagnosis, 549 (GIST) uterine adenocarcinomas, 72 genetics, 549 abdominal perivascular epithelioid cell tumors adenofibroma, 523 pathology, 548–549 (PEComas), 542 adenoid cystic carcinoma, 1035 aggressive angiomyxoma (AAM), 514–518 abdominal wall desmoids, 244 adenomatoid tumor, 811–813 clinical features, 514–516 acquired elastotic hemangioma, 598 adenomatous polyposis coli (APC) gene, 143 differential diagnosis, 518 acquired tufted angioma, 590 adenosarcoma (mullerian¨ adenosarcoma), 523 genetics, 518 acral arteriovenous tumor, 583 adipocytic lesions (cytology), 1017–1022 pathology, 516 acral myxoinflammatory fibroblastic sarcoma atypical lipomatous tumor/well- aggressive digital papillary adenocarcinoma, (AMIFS), 365–370, 1026 differentiated -
2016 Essentials of Dermatopathology Slide Library Handout Book
2016 Essentials of Dermatopathology Slide Library Handout Book April 8-10, 2016 JW Marriott Houston Downtown Houston, TX USA CASE #01 -- SLIDE #01 Diagnosis: Nodular fasciitis Case Summary: 12 year old male with a rapidly growing temple mass. Present for 4 weeks. Nodular fasciitis is a self-limited pseudosarcomatous proliferation that may cause clinical alarm due to its rapid growth. It is most common in young adults but occurs across a wide age range. This lesion is typically 3-5 cm and composed of bland fibroblasts and myofibroblasts without significant cytologic atypia arranged in a loose storiform pattern with areas of extravasated red blood cells. Mitoses may be numerous, but atypical mitotic figures are absent. Nodular fasciitis is a benign process, and recurrence is very rare (1%). Recent work has shown that the MYH9-USP6 gene fusion is present in approximately 90% of cases, and molecular techniques to show USP6 gene rearrangement may be a helpful ancillary tool in difficult cases or on small biopsy samples. Weiss SW, Goldblum JR. Enzinger and Weiss’s Soft Tissue Tumors, 5th edition. Mosby Elsevier. 2008. Erickson-Johnson MR, Chou MM, Evers BR, Roth CW, Seys AR, Jin L, Ye Y, Lau AW, Wang X, Oliveira AM. Nodular fasciitis: a novel model of transient neoplasia induced by MYH9-USP6 gene fusion. Lab Invest. 2011 Oct;91(10):1427-33. Amary MF, Ye H, Berisha F, Tirabosco R, Presneau N, Flanagan AM. Detection of USP6 gene rearrangement in nodular fasciitis: an important diagnostic tool. Virchows Arch. 2013 Jul;463(1):97-8. CONTRIBUTED BY KAREN FRITCHIE, MD 1 CASE #02 -- SLIDE #02 Diagnosis: Cellular fibrous histiocytoma Case Summary: 12 year old female with wrist mass. -
Acral Melanoma
Accepted Date : 07-Jul-2015 Article type : Original Article The BRAAFF checklist: a new dermoscopic algorithm for diagnosing acral melanoma Running head: Dermoscopy of acral melanoma Word count: 3138, Tables: 6, Figures: 6 A. Lallas,1 A. Kyrgidis,1 H. Koga,2 E. Moscarella,1 P. Tschandl,3 Z. Apalla,4 A. Di Stefani,5 D. Ioannides,2 H. Kittler,4 K. Kobayashi,6,7 E. Lazaridou,2 C. Longo,1 A. Phan,8 T. Saida,3 M. Tanaka,6 L. Thomas,8 I. Zalaudek,9 G. Argenziano.10 Article 1. Skin Cancer Unit, Arcispedale Santa Maria Nuova IRCCS, Reggio Emilia, Italy 2. Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan 3. Department of Dermatology, Division of General Dermatology, Medical University, Vienna, Austria 4. First Department of Dermatology, Medical School, Aristotle University, Thessaloniki, Greece 5. Division of Dermatology, Complesso Integrato Columbus, Rome, Italy 6. Department of Dermatology, Tokyo Women’s Medical University Medical Center East, Tokyo, Japan 7. Kobayashi Clinic, Tokyo, Japan 8. Department of Dermatology, Claude Bernard - Lyon 1 University, Centre Hospitalier Lyon-Sud, Pierre Bénite, France. 9. Department of Dermatology and Venereology, Medical University, Graz, Austria 10. Dermatology Unit, Second University of Naples, Naples, Italy. This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as Accepted doi: 10.1111/bjd.14045 This article is protected by copyright. All rights reserved. Please address all correspondence to: Aimilios Lallas, MD. -
Acral Lentiginous Melanoma in Situ: Dermoscopic Features and Management Strategy Byeol Han1,2, Keunyoung Hur1, Jungyoon Ohn1,2, Sophie Soyeon Lim3 & Je‑Ho Mun1,2*
www.nature.com/scientificreports OPEN Acral lentiginous melanoma in situ: dermoscopic features and management strategy Byeol Han1,2, Keunyoung Hur1, Jungyoon Ohn1,2, Sophie Soyeon Lim3 & Je‑Ho Mun1,2* Diagnosis of acral lentiginous melanoma in situ (ALMIS) is challenging. However, data regarding ALMIS are limited in the literature. The aim of this study was to investigate the clinical and dermoscopic features of ALMIS on palmoplantar surfaces. Patients with ALMIS and available dermoscopic images were retrospectively reviewed at our institution between January 2013 and February 2020. Clinical and dermoscopic features were analysed and compared between small (< 15 mm) and large (≥ 15 mm) ALMIS. Twenty‑one patients with ALMIS were included in this study. Mean patient age was 58.5 (range 39–76) years; most lesions were located on the sole (90.5%). The mean maximal diameter was 19.9 ± 13.7 mm (mean ± standard deviation). Statistical analysis of dermoscopic features revealed that parallel ridge patterns (54.5% vs. 100%, P = 0.035), irregular difuse pigmentation (27.3% vs. 100%, P = 0.001) and grey colour (18.2% vs. 90%, P = 0.002) were signifcantly less frequent in small lesions than in large lesions. We have also illustrated two unique cases of small ALMIS; their evolution and follow‑up dermoscopic examination are provided. In conclusion, this study described detailed dermoscopic fndings of ALMIS. Based on the present study and a review of the literature, we proposed a dermoscopic algorithm for the diagnosis of ALMIS. Acral lentiginous melanoma (ALM), frst described by Reed in 1976, is a histological subtype of cutaneous melanoma arising on the acral areas1,2. -
UC Davis Dermatology Online Journal
UC Davis Dermatology Online Journal Title Morphea-like complications to illicit gluteal silicone injections Permalink https://escholarship.org/uc/item/0xv5g3sn Journal Dermatology Online Journal, 21(4) Authors Tausend, William E Stewart, Larissa R Rapini, Ronald P Publication Date 2015 DOI 10.5070/D3214026271 License https://creativecommons.org/licenses/by-nc-nd/4.0/ 4.0 Peer reviewed eScholarship.org Powered by the California Digital Library University of California Volume 21 Number 4 April 2015 Case presentation Morphea-like complications to illicit gluteal silicone injections William E. Tausend MD1, Larissa R. Stewart MD2, Ronald P. Rapini MD2 Dermatology Online Journal 21 (4): 5 1University of Texas Medical Branch Department of Dermatology 2University of Texas Health Science Center-Houston Department of Dermatology Correspondence: William E. Tausend, MD 1122 Postoffice St. Galveston, Texas 77550 Phone-832-816-5524 [email protected] Abstract We present a case of a 39-year-old Hispanic woman who was referred to our clinic for treatment of several indurated plaques on her buttocks that developed one year prior to presentation, after she received injections of an unknown substance for augmentation. Biopsy of one nodule revealed silicone in the dermis. Keywords: Silicone injection, Procedural complications Introduction Illicit injections of silicone are an increasing and worrisome trend in the United States, especially in the Hispanic and transgender communities [1]. These procedures are often performed by unlicensed individuals who inject large quantities of unknown substances into patients [2,3]. The reasons for this increasing trend are thought to relate to the reduced cost of the procedures [4,5]. -
Misdiagnosed, Mistreated and Delay
erimenta xp l D E e r & m l a a t c o i l n o i Journal of Clinical & Experimental Scalvenzi et al., J Clin Exp Dermatol Res 2012, S:6 l g y C f R DOI: 10.4172/2155-9554.S6-002 o e l ISSN: 2155-9554 s a e n a r r u c o h J Dermatology Research Research Article Open Access Misdiagnosed, Mistreated and Delay Diagnosed Acral Melanoma: The Atypical Presentations Scalvenzi M*, Palmisano F and Costa C Departments of Dermatology, University of Naples Federico II, Italy Abstract Background: Acral skin is the most common site of malignant melanoma in non-Caucasian population. Diagnosis in this anatomic site is often delayed because this area is not routinely examined by patients or primary physicians. Objective: To perform an earlier diagnosis underlining the importance of dermoscopy helping clinicians to differentiate this disease from the other lesions and biopsies will result in more timely diagnoses and improved survival. Methods: We present 6 case studies visited in our Department of Dermatology of Naples University between October 2010 and September 2012. Results: These lesions often mimic other entities like warts, calli, bacterial or fungal infections, foreign bodies, vascular lesions, blisters, melanocytic nevi, subungual hematomas, pyogenic granulomas, onychomycosis, keratoacanthomas, diabetic foot ulcers, traumatic lesions that can lead to misdiagnosis and mistreatment. Conclusions: Awareness of atypical presentations of acral melanoma may be important to decrease misdiagnosis rates and improve patient outcome. Keywords: Acral melanoma; Foot; Misdiagnosis; Dermoscopy 5 cm in diameter (Figure 3a), misdiagnosed as a wart and treated for seven months with cryotherapy. -
Qt5085f0pn.Pdf
UC San Diego UC San Diego Previously Published Works Title Foreign Body Granulomas after All Injectable Dermal Fillers: Part 2. Treatment Options Permalink https://escholarship.org/uc/item/5085f0pn Author Lemperle, Gottfried Publication Date 2015-04-05 Peer reviewed eScholarship.org Powered by the California Digital Library University of California SPECIAL TOPIC Foreign Body Granulomas after All Injectable Dermal Fillers: Part 2. Treatment Options Foot Gottfried Lemperle, M.D., Summary: Foreign body granulomas occur at certain rates with all injectable Ph.D. dermal fillers. They have to be distinguished from early implant nodules, which Nelly Gauthier-Hazan, M.D. usually appear 2 to 4 weeks after injection. In general, foreign body granulomas San Diego, Calif.; and Paris, France appear after a latent period of several months at all injected sites at the same time. If diagnosed early and treated correctly, they can be diminished within a few weeks. The treatment of choice of this hyperactive granulation tissue is the intralesional injection of corticosteroid crystals (triamcinolone, betamethasone, or prednisolone), which may be repeated in 4-week cycles until the right dose is found. To lower the risk of skin atrophy, corticosteroids can be combined with antimitotic drugs such as 5-fluorouracil and pulsed lasers. Because foreign body granulomas grow fingerlike into the surrounding tissue, surgical excision should be the last option. Surgery or drainage is indicated to treat normal lumps and cystic foreign body granulomas with little tissue ingrowth. In most patients, a foreign body granuloma is a single event during a lifetime, often triggered by a systemic bacterial infection. (Plast. -
“Highly Cohesive” Silicone Breast Implants: a Histopathologic and Laser Raman Microprobe Analysis
International Journal of Environmental Research and Public Health Article A Case of Silicone and Sarcoid Granulomas in a Patient with “Highly Cohesive” Silicone Breast Implants: A Histopathologic and Laser Raman Microprobe Analysis Todor I. Todorov 1,†, Erik de Bakker 2,3, Diane Smith 4,‡, Lisette C. Langenberg 5, Linda A. Murakata 1,§, Mark H. H. Kramer 6 , Jose A. Centeno 1,k and Prabath W. B. Nanayakkara 4,* 1 Department of Environmental and Infectious Disease Sciences, Division of Biophysical Toxicology, Armed Forces Institute of Pathology, Washington, DC 20306, USA; [email protected] (T.I.T.); [email protected] (L.A.M.); [email protected] (J.A.C.) 2 Department of Plastic Surgery, VU University Medical Centre, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands; [email protected] 3 Department of Molecular Cell Biology and Immunology, VU University Medical Centre, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands 4 Henry Jackson Foundation, Bethesda, MD 20817, USA; [email protected] 5 Department of Internal Medicine, VU University Medical Centre, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands; [email protected] 6 Department of Pathology, VU University Medical Centre, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands; [email protected] * Correspondence: [email protected] † Current address: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Citation: Todorov, T.I.; de Bakker, E.; College Park, MD 20740, USA. Smith, D.; Langenberg, L.C.; ‡ Current address: Center for Device and Radiological Health, US Food and Drug Administration, Murakata, L.A.; Kramer, M.H.H.; Silver Spring, MD 20993, USA. -
Dermoscopic Patterns of Acral Melanocytic Lesions in Skin of Color
SKIN OF COLOR IN COLLABORATION WITH THE SKIN OF COLOR SOCIETY Dermoscopic Patterns of Acral Melanocytic Lesions in Skin of Color Andrea Tan, BS; Jennifer A. Stein, MD, PhD Population Trends in Skin of Color PRACTICE POINTS Much of the literature on malignant melanoma his- • Dermatologists should be familiar with common torically has involved non-Hispanic white patients, but dermoscopic patterns seen at acral sites in patients the incidence in lighter-skinned populations has been with skin of color as well as the most up-to-date increasing steadily over the last few decades.1 Although diagnostic algorithms. ALM can occur in any race, it disproportionately affects • Acral lentiginous melanoma should be strongly sus- skin of color populations;copy ALM accounts for only 0.8% to pected if dermoscopy reveals a parallel ridge pattern 1% of all melanomas in white populations, but it consti- or if dermoscopy of volar skin reveals a lack of typi- tutes 4% to 58% of melanomas in ethnic populations and cal dermoscopic patterns in lesions with a diameter is the most common melanoma subtype among black greater than 7 mm. Americans.2-5 Acral lentiginous melanoma also is associ- atednot with a worse prognosis compared to other subtypes, which may indicate a more aggressive biological nature6 but also may point toward socioeconomic and cultural Acral lentiginous melanoma (ALM) is a rare but aggressive subtype barriers (eg, low income or education levels, lack of insur- of melanoma often associated with poor prognosis. Although overallDo incidence is rare, ALM accounts for a larger proportion of mela- ance, lower health literacy), leading to disparities in access 5 nomas among black, Asian, and Hispanic individuals than among to care and diagnosis at advanced stages.