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Acral Lentiginous Melanoma Diagnosed Using Combination of Dermoscopic and Histopathological Examination

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Acral Lentiginous Melanoma Diagnosed Using Combination of Dermoscopic and Histopathological Examination Acral Lentiginous Melanoma Diagnosed using Combination of Dermoscopic and Histopathological Examination Calvin Santosa1, Ni Luh Putu Ratih Vibriyanti Karna1, A. A. Ari Agung Kayika Silayukti2, Herman Saputra3 1Dermatovenereology Department Sanglah General Public Hospital, Denpasar, Indonesia 2Dermatovenereology Department Mangunsada General Public Hospital, Badung, Indonesia 3Pathology Department Sanglah General Public Hospital, Denpasar, Indonesia Keywords: melanoma, acral lentiginous, dermoscopy, histopathology Abstract: Melanoma is a malignant tumor, which arises from melanocyte, and most commonly appears initially on the skin. Melanoma may arise also on mucosal surface even the leptomeningeal. Risk factors for melanoma could come endogenously and exogenously. Melanoma is still one of the leading causes of death by cancer in the world. Acral lentiginous melanoma (ALM) is an uncommon type of melanoma and usually diagnosed in the elderly on the extremities or nails. Clinically acral melanoma may be diagnosed as fungal infection or benign nevus lesion. Dermoscopy has helped clinician in differentiating between benign and malignant nevus lesion, hence not all cases need histopathological examination. Pathognomonic findings in melanoma lesion through dermoscopic examination may assist dermatologist in diagnosing melanoma. Main treatment for melanoma is still wide excision of the lesion and periodic monitoring post excision necessary to evaluate the risk of metastasis and mortality. 1 INTRODUCTION diagnose melanoma still requires histopathological examination, but with the discovery of dermoscopy Melanoma is a malignant tumor of melanocytes that has reduced the number of nevus lesions that do not can occur in the skin, mucosa and leptomeningeal. A show malignant features (Saida et al., 2011). clinical feature that may resemble ordinary nevus The main therapy for melanoma is surgical often makes the patient unaware of the condition excision. If there is a sign of metastasis, additional (Garbe and Bauer, 2012). Epidemiologically chemotherapy and immunotherapy should be given melanoma is more commonly found in Fitzpatrick (Saiag et al., 2007). The following case of acral skin type I and II who received excessive sun lentiginous melanoma is diagnosed using exposure. In Europe an incidence of 10-25 new combination of dermoscopy and histopathology cases per 100,000 population is found per year, examination. This case is reported due to a relatively whereas in the United States 20-30 cases per low incidence in Indonesia and to increase 100,000 people and the highest in Australia is 50-60 understanding of melanoma, diagnosis and cases per 100,000 population (Garbe and Leiter, appropriate management. 2009; Ferlay et al., 2013). In Indonesia alone the incidence vary but still very low. In RS Dr. M. Djamil Padang found 9 cases of melanoma during 2 CASE 2002-2007 (Azamris, 2011). Acral lentiginous melanoma (ALM) is a rare A 53-year-old Balinese mancame to type of cutaneous melanoma and is often diagnosed Dermatovenereology polyclinic of Mangunsada at the later stage with lesions in the palms, soles or Badung Hospital with a chief complaint of dark spot inside or around the nails. This condition tends to be on the right sole of his foot. found in African and Asian racial groups where Patient has a history oftrauma from a tree thorn 1 rarely found melanoma cases due to excessive sun year ago and the patient felt that there was a thorn exposure (Bradford et al., 2009). The way to that is embedded in his foot. Patients tried to remove 363 Santosa, C., Vibriyanti Karna, N., Silayukti, A. and Saputra, H. Acral Lentiginous Melanoma Diagnosed using Combination of Dermoscopic and Histopathological Examination. DOI: 10.5220/0008157503630367 In Proceedings of the 23rd Regional Conference of Dermatology (RCD 2018), pages 363-367 ISBN: 978-989-758-494-7 Copyright c 2021 by SCITEPRESS – Science and Technology Publications, Lda. All rights reserved RCD 2018 - The 23rd Regional Conference of Dermatology 2018 it without any help of medical personnel. About 10 lesion (red arrow Figure 1B-D) andon the ulcer months ago the patient claimed to have black spots showed blood vessel in dots form (red arrow appear on the trauma area on his right sole. Patients Figure 1 E), bluish globule (asterisk Figure 1E) and claimed no pain or itching on that area. The dark structureless area (circle Figure 1E). On the edge of spots slowly spread to the adjacent area. History of the ulcer there were mass of keratin with a previous mole on the area is denied. Patients homogeneous black spot on some foci. mentioned about awound which appear on the black Histopathological examination found epidermal spots 2 weeks before admission. The patient does layer with a picture of acanthosis accompanied by a not feel any pain on the when being touched. thick layer of keratin. There is a proliferation of Patients claimed to have never treated the atypical melanocyte cells along the basal epidermis condition since 1 year ago. History of similar with disturbed cohesion with relatively large sized condition in other location was not found. History of morphologies, vacuolized cytoplasm, bizarre malignancy is denied. History of systemic diseases nucleus, hyperchromatic, partially with prominent such as hypertension, diabetes mellitus, bleeding nucleus, and irregular nucleic membrane. These disorders are denied by the patient. History of any cells contain brownish pigmented granules (melanin). immunosuppressive conditions was denied. History Some of these cells extend along the superficial of similar disease in the patient's family is denied. dermis. Mitosis can be found. The superficial dermis History of malignancy, asthma, hypertension or layer looks degenerated and thin. At 1 focus contains diabetes mellitus in patient families is denied. necrotic areas with necrotic debris. This fit with the Currentlypatient works as a farmer and often does morphological picture of an acral-lentiginous not use any footwear during work. Patients have no melanoma. (Figure 2). habit of alcohol consumption or smoking. Based on the dermoscopic and histopathological Physical examination found the general examination, this patient was diagnosed with acral condition of the patient good. Blood pressure 120/80 lentiginous melanoma and was performed wide mmHg, pulse 84x/minute, respiratory frequency excision of the lesion with a margin of 1 cm and as 20x/minute and axillary temperature 36.4°C. deep as subcutaneous tissue. The tissue obtained General status were within normal limit. No from the excision were examined again and there enlarged lymph nodes were found. The were clear margin of the lesion. The patient later on dermatological status onthe right plantar pedis there got a skin graft from calf area to close the surgical are multiple hyperpigmentation macules, well- area. The patient was also recommended to do defined margin, sized 2x3 cm to 5x7 cm with a annual check up for the first 5 year. solitary ulcer above it with rising and regular edge, clean base, round, 1.5 cm in diameter. (Figure 1A) On the investigation using dermoscopy, there are found parallel ridge pattern on the hyperpigmented A B C D E Figure 1: (A) Hyperpigmented lesion on right sole with solitary ulcer on it. Dermoscopic pattern of the lesion (B,C,D,E). 364 Acral Lentiginous Melanoma Diagnosed using Combination of Dermoscopic and Histopathological Examination A B C D E F Figure 2: Histopathological image from the lesion suit with acral lentiginous melanoma. 3 DISCUSSION radiation; especially ultraviolet B. Chronic radiation can cause mutations and DNA damage which disrupt Melanoma is a tumor derived from melanocytes and the cell cycle. In a study that assessed the role of can be foundon skin, mucosal, eyes and brain trauma in the occurrence of ALM in areas not meningeal. Acral melanoma itself is a subtype most exposed to sunlight such as soles of the feet, hands commonly found in non-white populations. This and nails found about 13-55% of cases of ALM has subtype includes>70% melanoma in African races in a history of previous trauma, but its relation to the America as well as 50% in Asian racial groups development of melanoma is still unclear (Phan et (Ishihara et al., 2008). al., 2006). Risk factors from melanoma can be divided into Diagnosis of melanoma requires correlation of 3 categories including genetic factors, phenotypic clinical features, dermoscopy and histopathology. manifestations of genetic and environmental Clinically lesions of melanoma appear as interactions also environmental factors. Genetic asymmetrical lesions, having irregular edges, has mutations or polymorphism can increase one variety of colors, diameters greater than 5 mm and person's tendency for the development of melanoma. found growth of nodules or regression components The focus of genes associated with familial in the lesions. The sensitivity of these clinical melanoma is CDKN2A, which plays a role in coding features to diagnose melanoma can be as high as proteins p16 and p14 that function in the course of 70% if performed by an experienced dermatologist. cell cycle. In addition, variants of the melanocortin-1 The most common and typical dermoscopic features receptor gene (MC1R) were also found to increase for ALM are the presence of parallel-ridge patterns the risk of melanoma formation. Factors that are that have a specificity of 99%, sensitivity of 86% phenotypic manifestations of genetic and and a positive predictive value of 84%. The next environmental interactions are melanocytic nevus, most common pattern is the brownish-colored atypical melanocytic nevus and ephelids and lentigo pigment found in ALM in situ and invasive ALM. solaris. Environmental factors that play a role in the Another feature that can be found is a serrated formation of cutaneous melanoma are ultraviolet pattern consisting of a streak image at the edge of 365 RCD 2018 - The 23rd Regional Conference of Dermatology 2018 the tumor. Not infrequently also found ALM with and was treated with margin of 1 cm and as deep as ridge pattern accompanied by diffuse pigmentation subcutaneous tissue, with histopathological area.
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