Segmental Pigmentation Disorder with Congenital Heterochromia Iridis
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July 2020 Goal the Goal of the Residency Program Is to Develop Future Leaders in Both Research and Clinical Medicine
Residency Training Program July 2020 Goal The goal of the Residency Program is to develop future leaders in both research and clinical medicine. Flexibility within the program allows for the acquisition of fundamental working knowledge in all subspecialties of dermatology. All residents are taught a scholarly approach to patient care, aimed at integrating clinicopathologic observation with an understanding of the basic pathophysiologic processes of normal and abnormal skin. Penn’s Residency Program consists of conferences, seminars, clinical rotations, research, and an opportunity to participate in the teaching of medical students. An extensive introduction into the department and the William D. James, M.D. Director of Residency Program clinic/patient care service is given to first-year residents. A distinguished clinical faculty and research faculty, coupled with the clinical and laboratory facilities, provides residents with comprehensive training. An appreciation of and participation in the investigative process is an integral part of our residency. Graduates frequently earn clinical or basic science fellowship appointments at universities across the country. Examples of these include: pediatric dermatology, dermatopathology, dermatologic surgery, dermatoepidemiology, postdoctoral and Clinical Educator fellowships. Additional post graduate training has occurred at the NIH and CDC. Graduates of our program populate the faculty at Harvard, Penn, Johns Hopkins, MD Anderson, Dartmouth, Penn State, Washington University, and the Universities of Washington, Pittsburgh, Vermont, South Carolina, Massachusetts, Wisconsin, and the University of California San Francisco. Additionally, some enter private practice to become pillars of community medicine. Misha A. Rosenbach, M.D. Associate Director of Residency Program History The first medical school in America, founded in 1765, was named the College of Philadelphia. -
Expanding Phenotype of Hereditary Fibrosing Poikiloderma with Tendon
CASE SERIES Expanding phenotype of hereditary fibrosing poikiloderma with tendon contractures, myopathy, and pulmonary fibrosis caused by FAM111B mutations: Report of an additional family raising the question of cancer predisposition and a short review of early-onset poikiloderma Rapha€elle Goussot, MD,a Megana Prasad, MD,b Corinne Stoetzel, MD,b Cedric Lenormand, MD, PhD,a Helene Dollfus, MD, PhD,b and Dan Lipsker, MD, PhDa Strasbourg, France Key words: FAM111B; inherited poikiloderma; pancreatic cancer. ereditary fibrosing poikiloderma with Abbreviations used: tendon contractures, myopathy, and pul- monary fibrosis (POIKTMP [MIM#615704]) IPMN: intraductal papillary mucinous H neoplasm is an extremely rare syndromic form of autosomal POIKTMP: hereditary fibrosing poikiloderma dominant poikiloderma. This genetic disorder was with tendon contractures, myopathy, first identified in a South African family in 2006.1 To and pulmonary fibrosis date, 3 families and 9 independent sporadic cases RTS: Rothmund-Thomson syndrome have been reported.2-4 Here we report an additional family of POIKTMP and expand the clinical spec- trum. We describe, for the first time to our knowl- early childhood. Clinical evaluation found a very edge, a pancreatic cancer in the clinical course in 1 severe case of poikiloderma, predominant in the patient. We also address the differential diagnosis of sun-exposed areas, resulting from the combination inherited poikiloderma and related disorders. of skin atrophy, mottled pigmentation with hyper- pigmented and hypopigmented lesions, and telan- CASE SERIES giectasia (Fig 1, A). He had a distinct intolerance for In 2007, at the Strasbourg University Hospital, the heat with marked hypohidrosis. Diffuse xerosis was department of medical genetics referred a family to combined with multiple depigmented macules on the dermatology department with a diverse clinical the trunk and limbs. -
Pattern of Skin Diseases at University of Benin Teaching Hospital, Benin City, Edo State, South-South Nigeria: a 12 Month Prospective Study
www.ccsenet.org/gjhs Global Journal of Health Science Vol. 4, No. 3; 2012 Pattern of Skin Diseases at University of Benin Teaching Hospital, Benin City, Edo State, South-South Nigeria: A 12 Month Prospective Study B. A. Ukonu1 & E. U. Eze2 1 University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria 2 University of Benin Teaching Hospital, Benin City, Edo State, Nigeria Correspondence: Ukonu, Agwu Bob (MBBS, FMCP), University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria. Tel: 234-805-791-5902, 234-702-675-1965. E-mail: [email protected] Received: January 4, 2012 Accepted: January 15, 2012 Online Published: May 1, 2012 doi:10.5539/gjhs.v4n3p148 URL: http://dx.doi.org/10.5539/gjhs.v4n3p148 Abstract Background and Objective: This study aims to look at the pattern and incidence of skin diseases seen in Dermatology/Venereology clinic at the University of Benin Teaching Hospital, Benin City, Edo State, South-South Zone, Nigeria and compare it with other zones of Nigeria. Materials and Methods: This was a prospective study on pattern and incidence of skin diseases in new patients presenting at the Dermatology/ Venereology outpatient clinic of the University of Benin Teaching Hospital, Benin City, Edo State, South-South, Nigeria, from September 2006 to August 2007. All patients were seen by the researchers. Diagnosis were made clinically and sometimes with the support of histopathology. Results: A total number of 4786 patients were seen during the study period and these comprised 2647 HIV/AIDS patients and 2112 pure Dermatological patients. Out of 4786 patients, 755 (15.8%) were new patients. -
The Effectiveness of Topical Scar-Reducing Therapies Administered for Scarring Due to Burns and Other Causes: a Retrospective Pilot Clinical Research
ORIGINAL ARTICLE Aksoy et al. / Gulhane Med J 2018;60: 139-144 139 The effectiveness of topical scar-reducing therapies administered for scarring due to burns and other causes: A retrospective pilot clinical research Hasan Mete Aksoy,1 Berna Aksoy,2 Aslı Tatlıparmak,2 Emel Çalıkoğlu3 (1) Bahçeşehir University, School of Medicine, Plastic and Reconstructive Surgery, Istanbul, Turkey (2) Bahçeşehir University, School of Medicine, Dermatology, Istanbul, Turkey (3) Aksaray University, Faculty of Medicine, Dermatology, Aksaray, Turkey Date submitted: ABSTRACT Oct 019, 2017 Aims: Multiple modalities are used to treat scarring; however, data on the efficacy of Date accepted: Aug 25, 2018 the topical scar-reducing treatments most frequently used by patients is insufficient. Online publication date: This study aimed to retrospectively determine the effectiveness of topical scar-reducing December 15, 2018 treatments and patients’ compliance. Methods: The medical records of patients adimitted for the treatment of scarring were retrospectively evaluated. Patient satisfaction with the treatment was assessed via telephone interviews. Each patient also sent recent photographs of their scars. Pre- and Corresponding Author: post-treatment photographs were scored according to the Manchester Scar Scale, and in Berna Aksoy terms of vascularity and scar surface area (modified MSS ). Bahcesehir University, School of Results: The study included 71 patients with a median scar age of 18 days at the time Medicine, Dermatology, Istanbul, treatment was initiated. Mean duration of follow-up was 41 months. The prescribed Turkey [email protected] treatments included onion extract, silicone gel or sheet, and a pressure garment. The patients reported that the treatments were effective, they were satisfied with the treatments, and the treatments were not excessively difficult to apply. -
Assessment of Melanocyte-Specific Primary and Memory Autoimmune Responses in Vitiligo- Prone Smyth and Vitiligo-Susceptible, Non-Expressing Brown Line Chickens
University of Arkansas, Fayetteville ScholarWorks@UARK Theses and Dissertations 8-2018 Assessment of Melanocyte-Specific rP imary and Memory Autoimmune Responses in Vitiligo-Prone Smyth and Vitiligo-Susceptible, Non-Expressing Brown Line Chickens Daniel Morales Falcon University of Arkansas, Fayetteville Follow this and additional works at: https://scholarworks.uark.edu/etd Part of the Cell Biology Commons, and the Immunology of Infectious Disease Commons Recommended Citation Falcon, Daniel Morales, "Assessment of Melanocyte-Specific rP imary and Memory Autoimmune Responses in Vitiligo-Prone Smyth and Vitiligo-Susceptible, Non-Expressing Brown Line Chickens" (2018). Theses and Dissertations. 2912. https://scholarworks.uark.edu/etd/2912 This Dissertation is brought to you for free and open access by ScholarWorks@UARK. It has been accepted for inclusion in Theses and Dissertations by an authorized administrator of ScholarWorks@UARK. For more information, please contact [email protected], [email protected]. Assessment of Melanocyte-Specific Primary and Memory Autoimmune Responses in Vitiligo- Prone Smyth and Vitiligo-Susceptible, Non-Expressing Brown Line Chickens A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Cell and Molecular Biology by Daniel Morales Falcon University of California, Riverside Bachelor of Science in Biology, 2003 August 2018 University of Arkansas This dissertation is approved for recommendation to the Graduate Council. ____________________________________ Gisela F. Erf, Ph.D. Dissertation Director ____________________________________ ___________________________________ Yuchun Du, Ph.D. David McNabb, Ph.D. Committee Member Committee Member ____________________________________ Suresh Thallapuranam, Ph.D. Committee Member Abstract Vitiligo is an acquired de-pigmentation disorder characterized by the post-natal loss of epidermal melanocytes (pigment-producing cells) resulting in the appearance of white patches in the skin. -
General Dermatology Practice Brochure
Appointments Our Providers David A. Cowan, MD, FAAD We are currently accepting • Fellow, American Academy of Dermatology new patients. • Associate, American College of Call today to schedule your appointment Mohs Micrographic Surgery Monday - Friday, 8:00am to 4:30pm Rebecca G. Pomerantz, MD 1-877-661-3376 • Board Certified, American Academy of Cancellations & “No Show” Policy Dermatology If you are unable to keep your scheduled Lisa L. Ellis, MPAS, PA-C appointment, please call the office and we will • Member, American Academy of Physician be more than happy to reschedule for you. Assistants Failure to notify us at least 48 hours prior to your • Member, PA Society of Physician Assistants Medical and appointment may result in a cancellation fee. • Member, Society of Dermatology Physician Prescription Refills Assistants Surgical Refill requests are handled during normal office Sheri L. Rolewski, MSN, CRNP-BC hours when our staff has full access to medical • National Board Certification, Family Nurse Dermatology records. Refills cannot be called in on holidays, Practitioner Specialty weekends or more than twelve months after your • Member, Dermatology Nurse Association last exam. Please have your pharmacy contact our office directly. Test Results SMy Dermatology Appointment You will be notified when we receive your Date/Day _____________________________________ pathology or other test results, usually within two weeks from the date of your procedure. If you Time _________________________________________ do not hear from us within three -
Dermatology at the Berkeley Outpatient Center
Dermatology Berkeley Outpatient Center Overview Encompassing both medical and cosmetic dermatology, our experts at the Berkeley Outpatient Center offer a full range of diagnostic, treatment and surgical services for patients with cutaneous conditions. Surgical Dermatology • Fellowship-trained expertise in • Close coordination with Plastic Surgery Mohs micrographic surgery for at the Berkeley Outpatient Center, treatment of skin cancers including allowing for streamlined treatment for basal cell carcinomas and squamous related procedures in one location cell carcinomas, as well as treatment of • Outpatient surgery for removal of melanoma in situ with MART-1 staining benign skin growths and skin cancers Medical Dermatology - Conditions Treated/Services Offered • Acne, rosacea and related conditions • Mole/Atypical nevus/Melanoma • Sun-damaged skin surveillance • Aesthetic/Cosmetic dermatology • Non-melanoma skin cancers • Eczema and atopic dermatitis • Pigmentation disorders • HIV/AIDS-related skin conditions • Psoriasis • Lumps under the skin • Rashes • Infections of the skin (bacterial, viral, • Skin checks for patients with fungal and other) concerning lesions • Melanoma • Warts When to see a Dermatologist For more information, please call Dermatology Services at (510) 985-5200. Dermatology Services Providing integrated care in the community. Our Dermatology Team Erin Amerson, MD Drew Saylor, MD, MPH UCSF Health UCSF Health Dermatologist Dermatologic surgeon To learn more about our doctors, visit ucsfhealth.org/find_a_doctor. Office location: Berkeley Outpatient Center 3100 San Pablo Avenue Berkeley, CA 94702 (510) 985-5200 To learn more about our Berkeley Outpatient Center, Adeline St visit johnmuirhealth.com/ September 2020 berkeleyopc.. -
E S P C R B U L L E T
E S P C R B U L L E T I N N° 54 April 2006 PUBLISHED BY THE EUROPEAN SOCIETY FOR PIGMENT CELL RESEARCH EDITOR: G. GHANEM (Brussels) INTERNATIONAL F. BEERMANN (Lausanne), J. BOROVANSKY (Prague), M. d’ISCHIA (Naples), JC GARCIA-BORRON (Murcia), , A. NAPOLITANO (Naples), M. PICARDO (Rome), N. SMIT (Leiden). EDITORIAL BOARD: R. MORANDINI (Brussels) Ed Ph In La stitu bor one ito 7. 3. 5. 2. 4. 8. 1. Review oftheliterature communications, ... Discussion, Letterstotheeditor,Reviews,Short CONTENTS Announcements andrelatedactivities 9. Melanomaexperime 6. ria at : t J.Bo 32 ory of Genetics, molecularand Neur Photobiology MSH, MCH,ot Melanosomes Tyrosinase, TRPs,otherenzymes l (DrA.Napolitano) Biology ofpigmentcells Chemistr Office (Dr M.Picardo) (Dr F.Beermann) (Prof JC.Garcia-Borron) - 2 - rdet, Ru 5 Onc 41 omel : .3 G. G o 2. l o 9 e Hég gy a 6 h y ofM a ani F n e n a e m d x: r-Bo Experi (Ed n (DrN.S 3 (Pro s 2 rd (ProfM.d'Ischia) - her hor ito 2 e et 1,B–10 - 5 r) me l a 41 , f J.Bo nt ni C. Meunier .3 al ntal 3. ns andot S 4 m mones u 9 rg 00 developmentalbiology , cellcult it) ery ro and pigmentarydisorders Bru , R. M ( van E-M L s sels, . O (DrR.Morandini) BULLETI R P S E her o .C a r sky i a . Belg l E : ndini g .) pi g ur , h ) ium. Uni a ( e gments n P e versi m ro @ duc u t é l t b Li i on Te . -
Cutaneous Manifestations of Newborns in Omdurman Maternity Hospital
ﺑﺴﻢ اﷲ اﻟﺮﺣﻤﻦ اﻟﺮﺣﻴﻢ Cutaneous Manifestations of Newborns in Omdurman Maternity Hospital A thesis submitted in the partial fulfillment of the degree of clinical MD in pediatrics and child health University of Khartoum By DR. AMNA ABDEL KHALIG MOHAMED ATTAR MBBS University of Khartoum Supervisor PROF. SALAH AHMED IBRAHIM MD, FRCP, FRCPCH Department of Pediatrics and Child Health University of Khartoum University of Khartoum The Graduate College Medical and Health Studies Board 2008 Dedication I dedicate my study to the Department of Pediatrics University of Khartoum hoping to be a true addition to neonatal care practice in Sudan. i Acknowledgment I would like to express my gratitude to my supervisor Prof. Salah Ahmed Ibrahim, Professor of Peadiatric and Child Health, who encouraged me throughout the study and provided me with advice and support. I am also grateful to Dr. Osman Suleiman Al-Khalifa, the Dermatologist for his support at the start of the study. Special thanks to the staff at Omdurman Maternity Hospital for their support. I am also grateful to all mothers and newborns without their participation and cooperation this study could not be possible. Love and appreciation to my family for their support, drive and kindness. ii Table of contents Dedication i Acknowledgement ii Table of contents iii English Abstract vii Arabic abstract ix List of abbreviations xi List of tables xiii List of figures xiv Chapter One: Introduction & Literature Review 1.1 The skin of NB 1 1.2 Traumatic lesions 5 1.3 Desquamation 8 1.4 Lanugo hair 9 1.5 -
COVID-19 Mrna Pfizer- Biontech Vaccine Analysis Print
COVID-19 mRNA Pfizer- BioNTech Vaccine Analysis Print All UK spontaneous reports received between 9/12/20 and 22/09/21 for mRNA Pfizer/BioNTech vaccine. A report of a suspected ADR to the Yellow Card scheme does not necessarily mean that it was caused by the vaccine, only that the reporter has a suspicion it may have. Underlying or previously undiagnosed illness unrelated to vaccination can also be factors in such reports. The relative number and nature of reports should therefore not be used to compare the safety of the different vaccines. All reports are kept under continual review in order to identify possible new risks. Report Run Date: 24-Sep-2021, Page 1 Case Series Drug Analysis Print Name: COVID-19 mRNA Pfizer- BioNTech vaccine analysis print Report Run Date: 24-Sep-2021 Data Lock Date: 22-Sep-2021 18:30:09 MedDRA Version: MedDRA 24.0 Reaction Name Total Fatal Blood disorders Anaemia deficiencies Anaemia folate deficiency 1 0 Anaemia vitamin B12 deficiency 2 0 Deficiency anaemia 1 0 Iron deficiency anaemia 6 0 Anaemias NEC Anaemia 97 0 Anaemia macrocytic 1 0 Anaemia megaloblastic 1 0 Autoimmune anaemia 2 0 Blood loss anaemia 1 0 Microcytic anaemia 1 0 Anaemias haemolytic NEC Coombs negative haemolytic anaemia 1 0 Haemolytic anaemia 6 0 Anaemias haemolytic immune Autoimmune haemolytic anaemia 9 0 Anaemias haemolytic mechanical factor Microangiopathic haemolytic anaemia 1 0 Bleeding tendencies Haemorrhagic diathesis 1 0 Increased tendency to bruise 35 0 Spontaneous haematoma 2 0 Coagulation factor deficiencies Acquired haemophilia -
Johnson, SL, Nguyen, AN, and Lister (2011) JA Mitfa Is Required At
Developmental Biology 350 (2011) 405–413 Contents lists available at ScienceDirect Developmental Biology journal homepage: www.elsevier.com/developmentalbiology mitfa is required at multiple stages of melanocyte differentiation but not to establish the melanocyte stem cell Stephen L. Johnson a, AnhThu N. Nguyen b, James A. Lister b,⁎ a Department of Genetics, Washington University, St. Louis, MO, USA b Department of Human and Molecular Genetics and Massey Cancer Center, Virginia Commonwealth University School of Medicine, Sanger Hall 11-014, PO Box 980033, Richmond, VA 23298 USA article info abstract Article history: The mitfa gene encodes a zebrafish ortholog of the microphthalmia-associated transcription factor (Mitf) which, Received for publication 3 August 2010 like its counterparts in other species, is absolutely required for development of neural crest melanocytes. In order Revised 22 November 2010 to evaluate mitfa's role in different stages of melanocyte development, we have identified hypomorphic alleles of Accepted 2 December 2010 mitfa, including two alleles that are temperature-sensitive for melanocyte development. Molecular analysis Available online 10 December 2010 revealed that the mitffh53ts results from a single base pair change producing an asparagine to tyrosine amino acid substitution in the DNA-binding domain, and the mitfavc7 ts allele is a mutation in a splice donor site that reduces Keywords: vc7 Melanocyte the level of correctly-spliced transcripts. Splicing in the mitfa allele does not itself appear to be temperature- z25 MITF dependent. A third, hypomorphic allele, mitfa results in an isoleucine to phenylalanine substitution in the first Zebrafish helix domain of the protein. Temperature upshift experiments with mitfafh53ts show that mitfa is required at Neural crest several stages of melanocyte differentiation, including for expression of the early melanoblast marker dct,again for progression from dct expression to differentiation, and again for maintenance of dendritic form following differentiation. -
Dermatology Patch Allergy Testing Post Service - Information Request Form
Dermatology Patch Allergy Testing Post Service - Information Request Form Blue Cross NC will review associated claim(s) for services rendered on the patient listed below. In order to determine benefits are available for the reported condition, please answer the questions below. If you would prefer to send medical records, relating to the condition for the dates listed you may do so. In this case, all answers must be supported by documentation in the patient's medical record. Please submit the completed form to Blue Cross NC per the Medical Record Submission instructions found on the bcbsnc.com provider site (https://www.bcbsnc.com/assets/providers/public/pdfs/submissions/how_to_submit_provider_initiated_medical_records.pdf) or if requested by Blue Cross NC via a bar-coded coversheet, please fax the form/medical records to the number noted on the bar-coded cover sheet within 7-10 days to facilitate the claim payment. This form must be filled out by the patient's physician or their designee which may be any of the following: Physician Assistant (PA), Nurse Practitioner (NP), Registered Nurse (RN), or Licensed Practical Nurse (LPN). Note: Credentials must be provided with signature or the form will be returned. PROVIDER INFORMATION Requesting Provider Information Place of Service Provider Name Facility Name Provider ID Facility ID PATIENT INFORMATION Patient Name:_____________________________ Patient DOB :_____________ Patient Account Number______________ Patient ID:______________ CLAIM INFORMATION Date(s) of Service_____________ CPT_________ Diagnosis_______ Dermatology Patch Allergy Testing - Information Request Form Page 1 of 3 CLINICAL INFORMATION Did the patient have direct skin testing (for immediate hypersensitivity) by: Percutaneous or epicutaneous (scratch, prick, or puncture)? ________________ Intradermal testing? ___________________________________ Inhalant allergy evaluation? _________________ Did the patient have patch (application) testing (most commonly used: T.R.U.E.