Optimal Management of Common Acquired Melanocytic Nevi (Moles): Current Perspectives
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Acral Compound Nevus SJ Yun S Korea
University of Pennsylvania, Founded by Ben Franklin in 1740 Disclosures Consultant for Myriad Genetics and for SciBase (might try to sell you a book, as well) Multidimensional Pathway Classification of Melanocytic Tumors WHO 4th Edition, 2018 Epidemiologic, Clinical, Histologic and Genomic Aspects of Melanoma David E. Elder, MB ChB, FRCPA University of Pennsylvania, Philadelphia, PA, USA Napa, May, 2018 3rd Edition, 2006 Malignant Melanoma • A malignant tumor of melanocytes • Not all melanomas are the same – variation in: – Epidemiology – risk factors, populations – Cell/Site of origin – Precursors – Clinical morphology – Microscopic morphology – Simulants – Genomic abnormalities Incidence of Melanoma D.M. Parkin et al. CSD/Site-Related Classification • Bastian’s CSD/Site-Related Classification (Taxonomy) of Melanoma – “The guiding principles for distinguishing taxa are genetic alterations that arise early during progression; clinical or histologic features of the primary tumor; characteristics of the host, such as age of onset, ethnicity, and skin type; and the role of environmental factors such as UV radiation.” Bastian 2015 Epithelium associated Site High UV Low UV Glabrous Mucosa Benign Acquired Spitz nevus nevus Atypical Dysplastic Spitz Borderline nevus tumor High Desmopl. Low-CSD Spitzoid Acral Mucosal Malignant CSD melanoma melanoma melanoma melanoma melanoma 105 Point mutations 103 Structural Rearrangements 2018 WHO Classification of Melanoma • Integrates Epidemiologic, Genomic, Clinical and Histopathologic Features • Assists -
Nevus Spilus: Is the Presence of Hair Associated with an Increased Risk for Melanoma?
Nevus Spilus: Is the Presence of Hair Associated With an Increased Risk for Melanoma? Robert Milton Gathings, MD; Raveena Reddy, MD; Ashish C. Bhatia, MD; Robert T. Brodell, MD PRACTICE POINTS • Nevus spilus (NS) appears as a café au lait macule studded with darker brown “moles.” • Although melanoma has been described in NS, it is rare. • There is no evidence that hairy NS are predisposed to melanoma. copy not Nevus spilus (NS), also known as speckled len- he term nevus spilus (NS), also known as tiginous nevus, is characterized by background speckled lentiginous nevus, was first used café au lait–like lentiginous melanocytic hyperpla- Tin the 19th century to describe lesions with sia speckled with small, 1- to 3-mm, darker foci.Do background café au lait–like lentiginous melanocytic Nevus spilus occurs in 1.3% to 2.3% of the adult hyperplasia speckled with small, 1- to 3-mm, darker population worldwide. Reports of melanoma aris- foci. The dark spots reflect lentigines; junctional, ing within hypertrichotic NS suggest that hyper- compound, and intradermal nevus cell nests; and trichosis may be a marker for the development of more rarely Spitz and blue nevi. Both macular and melanoma. We present a case of a hypertrichotic papular subtypes have been described.1 This birth- NS without melanoma and also provide a review of mark is quite common, occurring in 1.3% to 2.3% previously reported cases of hypertrichosis in NS. of the adult population worldwide.2 Hypertrichosis We believe that NS has aCUTIS lower risk for malignant has been described in NS.3-9 Two subsequent cases degeneration than congenital melanocytic nevi of malignant melanoma in hairy NS suggested that (CMN) of the same size, and it is unlikely that lesions may be particularly prone to malignant hypertrichosis is a marker for melanoma in NS. -
Acquired Bilateral Nevus of Ota–Like Macules (Hori's Nevus): a Case
Acquired Bilateral Nevus of Ota–like Macules (Hori’s Nevus): A Case Report and Treatment Update Jamie Hale, DO,* David Dorton, DO,** Kaisa van der Kooi, MD*** *Dermatology Resident, 2nd year, Largo Medical Center/NSUCOM, Largo, FL **Dermatologist, Teaching Faculty, Largo Medical Center/NSUCOM, Largo, FL ***Dermatopathologist, Teaching Faculty, Largo Medical Center/NSUCOM, Largo, FL Abstract This is a case of a 71-year-old African American female who presented with bilateral periorbital hyperpigmentation. After failing treatment with a topical retinoid and hydroquinone, a biopsy was performed and was consistent with acquired bilateral nevus of Ota-like macules, or Hori’s nevus. A review of histopathology, etiology, and treatment is discussed below. cream and tretinoin 0.05% gel. At this visit, a Introduction Figure 2 Acquired nevus of Ota-like macules (ABNOM), punch biopsy of her left zygoma was performed. or Hori’s nevus, clinically presents as bilateral, Histopathology reported sparse proliferation blue-gray to gray-brown macules of the zygomatic of irregularly shaped, haphazardly arranged melanocytes extending from the superficial area. It less often presents on the forehead, upper reticular dermis to mid-deep reticular dermis outer eyelids, and nose.1 It is most common in women of Asian descent and has been reported Figure 4 in ages 20 to 70. Classically, the eye and oral mucosa are uninvolved. This condition is commonly misdiagnosed as melasma.1 The etiology of this condition is not fully understood, and therefore no standardized treatment has been Figure 3 established. Case Report A 71-year-old African American female initially presented with a two week history of a pruritic, flaky rash with discoloration of her face. -
A Nevus of OTA with Intraoral Involvement: a Rare Case Report
Shivare P. et al.: Nevus of OTA- a rare entity CASE REPORT A Nevus of OTA with Intraoral Involvement: A Rare Case Report Peeyush Shivhare1, Lata S.2, Monu Yadav3, Naqoosh Haidry4, Shruthi T. Patil5 1,5- Senior lecturer department of oral medicine and radiology, Narsinhbhai patel dental college and hospital, Visnagar, Gujarat. 2- Professor and head of the department, Rungta Correspondence to: College Of Dental Sciences And Research, Bhilai, Chhattisgarh. 3- PG student. Dr. Peeyush Shivhare Senior lecturer department of Department Of Oral Medicine And Radiology, Carrier Dental College And Hospital. oral medicine and radiology, Narsinhbhai patel dental Lucknow. 4- Senior lecturer department of maxillofacial surgery, Narsinhbhai patel college and hospital, Visnagar, Gujarat. dental college and hospital, Visnagar, Gujarat. Contact Us: www.ijohmr.com ABSTRACT Nevus of Ota, which originally was described by Ota and Tanino in 1939. It is characterized as congenital or acquired hamartoma of dermal melanocytes, presents clinically as a blue or gray patch on the face within the distribution of the ophthalmic and maxillary branches of the fifth cranial (trigeminal) nerve. Involvement of the palatal mucosa occurs rarely in nevus of Ota, when it occurs, it usually blends with the oral mucosa and is typically irregular, ill defined and often present as a mottled patch. Nevus of Ota is rare in the Indian subcontinent. So far very less cases of nevus of ota with intraoral involvement have been documented in the English literature. We report a rare case of intraoral nevus of Ota in a 20 year-old female patient. KEYWORDS: Nevus of Ota, Melanoma, Hamartoma, Glaucoma AA aaaasasasss INTRODUCTION The nevus of Ota (nevus fuscoceruleus ophthal- momaxillaris” or oculodermal melanocytosis) is a macular discoloration of the face, found most commonly in the Japanese people.1 Nevus of ota develops when the melanocyte get entrapped in the upper third of the dermis. -
Acral Melanoma
Accepted Date : 07-Jul-2015 Article type : Original Article The BRAAFF checklist: a new dermoscopic algorithm for diagnosing acral melanoma Running head: Dermoscopy of acral melanoma Word count: 3138, Tables: 6, Figures: 6 A. Lallas,1 A. Kyrgidis,1 H. Koga,2 E. Moscarella,1 P. Tschandl,3 Z. Apalla,4 A. Di Stefani,5 D. Ioannides,2 H. Kittler,4 K. Kobayashi,6,7 E. Lazaridou,2 C. Longo,1 A. Phan,8 T. Saida,3 M. Tanaka,6 L. Thomas,8 I. Zalaudek,9 G. Argenziano.10 Article 1. Skin Cancer Unit, Arcispedale Santa Maria Nuova IRCCS, Reggio Emilia, Italy 2. Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan 3. Department of Dermatology, Division of General Dermatology, Medical University, Vienna, Austria 4. First Department of Dermatology, Medical School, Aristotle University, Thessaloniki, Greece 5. Division of Dermatology, Complesso Integrato Columbus, Rome, Italy 6. Department of Dermatology, Tokyo Women’s Medical University Medical Center East, Tokyo, Japan 7. Kobayashi Clinic, Tokyo, Japan 8. Department of Dermatology, Claude Bernard - Lyon 1 University, Centre Hospitalier Lyon-Sud, Pierre Bénite, France. 9. Department of Dermatology and Venereology, Medical University, Graz, Austria 10. Dermatology Unit, Second University of Naples, Naples, Italy. This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as Accepted doi: 10.1111/bjd.14045 This article is protected by copyright. All rights reserved. Please address all correspondence to: Aimilios Lallas, MD. -
Nevus of Ota in Children
PEDIATRIC DERMATOLOGY Series Editor: Camila K. Janniger, MD Nevus of Ota in Children Smeeta Sinha, MD; Philip J. Cohen, MD; Robert A. Schwartz, MD, MPH Nevus of Ota, synonymously termed oculodermal seen most commonly in individuals of Japanese melanosis, is an uncommon dermal melanosis descent, and is less likely to present in individuals most commonly seen at birth in children of of Chinese or Korean descent, though individuals Japanese descent, though it can affect individu- descending from the Indian subcontinent, Africa, als of any age or ethnicity. The disease tends to and Europe also may be affected.7 In early sur- persist and extend locally, becoming increasingly veys of Japanese patients at dermatology clinics, prominent with age, puberty, and postmenopausal the incidence of nevus of Ota was determined to state. Treatment should begin early after diagno- be 0.4% (110/27,500).4 Cowan and Balistocky8 sis using multiple sessions of laser photother- calculated the incidence of oculodermal melano- molysis to avoid darkening and extension of the cytosis in black patients to be 0.016%. A study of lesion. Important associated disorders include 2914 Chinese children in Calgary, Alberta, Canada, ipsilateral glaucoma; intracranial melanocyto- reported an incidence of oculodermal melanocytosis sis; and rarely cutaneous, ocular, or intracranial of 0.034% (1/2914).9 melanoma. Recommendations are discussed for managing nevus of Ota in children. Clinical Manifestation Cutis. 2008;82:25-29. The typical nevus of Ota is a unilateral facial dis- coloration that is macular, speckled, and bluish gray or brown, with edges that blend with bordering skin evus of Ota is a rare disorder characterized (Figure).10 The dermatomal distribution of pigment by melanocytic pigmentation of the sclera characterizes this diagnosis in most cases. -
Nevus of Ota – an Intraoral Presentation: a Case Report Jennifer Maguire1* and Deborah Holt2
Maguire and Holt Journal of Medical Case Reports (2019) 13:174 https://doi.org/10.1186/s13256-019-2101-0 CASEREPORT Open Access Nevus of Ota – an intraoral presentation: a case report Jennifer Maguire1* and Deborah Holt2 Abstract Background: Nevus of Ota or “oculodermal melanocytosis” is a rare congenital hamartoma of dermal melanocytes causing a blue-gray hyperpigmentation of the eye and surrounding structures. The condition, originally described by Ota and Tanino in 1939, mainly affects the ophthalmic and maxillary divisions of the trigeminal nerve. We describe the first reported case of unilateral oculodermal melanocytosis in a Caucasian woman with oral buccal mucosal involvement. Oral involvement of nevus of Ota is very rare. Case presentation: A 48-year-old Caucasian woman was referred by the dermatology division to the oral medicine department at the University of Liverpool School of Dentistry with new-onset oral pigmentation to the left buccal mucosa. The patient had a previous diagnosis of oculodermal nevus. Conclusion: An incisional biopsy of the left buccal mucosa was completed. The report stated that histological and immunohistochemical features were in keeping with a blue nevus, but within the context of the preexisting occulodermal pigmentation, a diagnosis of oculodermal melanocytosis, also known as “nevus of Ota,” was made. The patient will be kept under review in the oral medicine department because the progression of the lesion on the left buccal mucosa requires active monitoring owing to the potential for malignant change. The patient also requires regular review in the dermatology and ophthalmology divisions. Keywords: Oral, Pigmentation, Nevus, Ota, Oculodermal, Buccal, Mucosa Background the left buccal mucosa. -
Acral Lentiginous Melanoma in Situ: Dermoscopic Features and Management Strategy Byeol Han1,2, Keunyoung Hur1, Jungyoon Ohn1,2, Sophie Soyeon Lim3 & Je‑Ho Mun1,2*
www.nature.com/scientificreports OPEN Acral lentiginous melanoma in situ: dermoscopic features and management strategy Byeol Han1,2, Keunyoung Hur1, Jungyoon Ohn1,2, Sophie Soyeon Lim3 & Je‑Ho Mun1,2* Diagnosis of acral lentiginous melanoma in situ (ALMIS) is challenging. However, data regarding ALMIS are limited in the literature. The aim of this study was to investigate the clinical and dermoscopic features of ALMIS on palmoplantar surfaces. Patients with ALMIS and available dermoscopic images were retrospectively reviewed at our institution between January 2013 and February 2020. Clinical and dermoscopic features were analysed and compared between small (< 15 mm) and large (≥ 15 mm) ALMIS. Twenty‑one patients with ALMIS were included in this study. Mean patient age was 58.5 (range 39–76) years; most lesions were located on the sole (90.5%). The mean maximal diameter was 19.9 ± 13.7 mm (mean ± standard deviation). Statistical analysis of dermoscopic features revealed that parallel ridge patterns (54.5% vs. 100%, P = 0.035), irregular difuse pigmentation (27.3% vs. 100%, P = 0.001) and grey colour (18.2% vs. 90%, P = 0.002) were signifcantly less frequent in small lesions than in large lesions. We have also illustrated two unique cases of small ALMIS; their evolution and follow‑up dermoscopic examination are provided. In conclusion, this study described detailed dermoscopic fndings of ALMIS. Based on the present study and a review of the literature, we proposed a dermoscopic algorithm for the diagnosis of ALMIS. Acral lentiginous melanoma (ALM), frst described by Reed in 1976, is a histological subtype of cutaneous melanoma arising on the acral areas1,2. -
Nevus of Ota: Clinical-Ophthalmological Findings Nevo De Ota: Achados Clínicos E Oftalmológicos
278 ARTIGO ORIGINAL Nevus of Ota: clinical-ophthalmological findings Nevo de Ota: achados clínicos e oftalmológicos Sebastião Cronemberger1, Nassim Calixto1, Henrique Leite Freitas2 ABSTRACT Objective: To analyze the clinical and ophthalmological findings of patients with nevus of Ota. Methods: Retrospective analysis of patients’ charts with nevus of Ota. We registered the demographic data, location of the nevus and date of appearance, family history of similar spots, biomicroscopic, gonioscopic, tonometric, ophthalmoscopic and perimetric findings. Results: We included 14 patients, six (43.0%) men and eight (57.0%) women, with a mean age of 21.7±17.5 years. Ten (71%) were mulatto, three (21.4%) white and one (7.1%) black. Twelve (85.7%) patients presented the spots at birth and two in puberty. Nine patients presented conjunctival and episcleral pigmentation in the right eye and five in the left eye. According to Tanino’s classification, five (35.7%) nevi were class 1, eight (57.1%) class 2 and one (7.1%) class 3. Heterochromia iridis was found in eight (57.1%) patients. Anisocoria was present in three (21.4%) patients. Five (35.7%) patients presented a suspected glaucomatous cup disc ratio (≥0.7); six (42.9%) presented a cup disc ratio ≤ 0.5 and three (21.4%), no cup disc. We found two curious and remarkable findings: a nevus of Ota on the palate of one patient and other on the optic disc associated with a pigmentary mottling of the fundus in another patient. The pigmentary mottling of the fundus was also seen in four more eyes. Conclusions: The nevus of Ota was frequently present at birth, in mulattos, and classified as Tanino’s class 1 and 2. -
A Deep Learning System for Differential Diagnosis of Skin Diseases
A deep learning system for differential diagnosis of skin diseases 1 1 1 1 1 1,2 † Yuan Liu , Ayush Jain , Clara Eng , David H. Way , Kang Lee , Peggy Bui , Kimberly Kanada , ‡ 1 1 1 Guilherme de Oliveira Marinho , Jessica Gallegos , Sara Gabriele , Vishakha Gupta , Nalini 1,3,§ 1 4 1 1 Singh , Vivek Natarajan , Rainer Hofmann-Wellenhof , Greg S. Corrado , Lily H. Peng , Dale 1 1 † 1, 1, 1, R. Webster , Dennis Ai , Susan Huang , Yun Liu * , R. Carter Dunn * *, David Coz * * Affiliations: 1 G oogle Health, Palo Alto, CA, USA 2 U niversity of California, San Francisco, CA, USA 3 M assachusetts Institute of Technology, Cambridge, MA, USA 4 M edical University of Graz, Graz, Austria † W ork done at Google Health via Advanced Clinical. ‡ W ork done at Google Health via Adecco Staffing. § W ork done at Google Health. *Corresponding author: [email protected] **These authors contributed equally to this work. Abstract Skin and subcutaneous conditions affect an estimated 1.9 billion people at any given time and remain the fourth leading cause of non-fatal disease burden worldwide. Access to dermatology care is limited due to a shortage of dermatologists, causing long wait times and leading patients to seek dermatologic care from general practitioners. However, the diagnostic accuracy of general practitioners has been reported to be only 0.24-0.70 (compared to 0.77-0.96 for dermatologists), resulting in over- and under-referrals, delays in care, and errors in diagnosis and treatment. In this paper, we developed a deep learning system (DLS) to provide a differential diagnosis of skin conditions for clinical cases (skin photographs and associated medical histories). -
Inflammatory Juvenile Compound Conjunctival Nevi. a Clinicopathological Study and Literature Review
Rom J Morphol Embryol 2017, 58(3):in press R J M E EVIEW AND ASE ERIES Romanian Journal of R C S Morphology & Embryology http://www.rjme.ro/ Inflammatory juvenile compound conjunctival nevi. A clinicopathological study and literature review CLAUDIA FLORIDA COSTEA1,2), MIHAELA DANA TURLIUC3,4), GABRIELA DIMITRIU2), CAMELIA MARGARETA BOGDĂNICI1), ANCA MOŢOC2), MĂDĂLINA ADRIANA CHIHAIA2), CRISTINA DANCĂ2), ANDREI CUCU4), ALEXANDRU CĂRĂULEANU5), NICOLETA DUMITRESCU6), LUCIA INDREI7), ŞERBAN TURLIUC8) 1)Department of Ophthalmology, “Grigore T. Popa” University of Medicine and Pharmacy, Iaşi, Romania 2)2nd Ophthalmology Clinic, “Prof. Dr. Nicolae Oblu” Emergency Clinical Hospital, Iaşi, Romania 3)Department of Neurosurgery, “Grigore T. Popa” University of Medicine and Pharmacy, Iaşi, Romania 4)2nd Neurosurgery Clinic, “Prof. Dr. Nicolae Oblu” Emergency Clinical Hospital, Iaşi, Romania 5)Department of Obstetrics and Gynecology, “Grigore T. Popa” University of Medicine and Pharmacy, Iaşi, Romania 6)4th Year Student, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, Iaşi, Romania 7)3rd Year Student, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania 8)Department of Psychiatry, “Grigore T. Popa” University of Medicine and Pharmacy, Iaşi, Romania Abstract Aim: The conjunctival nevus affecting children and adolescents is a rare condition and the literature showed only few reports on this issue. The aim of this article is to determine the histopathological features for the correct diagnosis of an inflammatory juvenile compound nevus of the conjunctiva (IJCNC) in order to make the difference between this tumor and other lesions, like conjunctival melanoma or lymphoma, very similar from a gross point of view. -
Toma, 539 Acinic Cell Carcinoma Mucinous Adenocarcinoma Vs., 334
Cambridge University Press 978-0-521-87999-6 - Head and Neck Margaret Brandwein-Gensler Index More information INDEX acanthomatous/desmoplastic ameloblas- ameloblastomas benign neoplasia toma, 539 desmoplastic ameloblastoma, 539 juvenile nasopharyngeal angiofibroma, acinic cell carcinoma metastasizing ameloblastoma, 537 99–104 mucinous adenocarcinoma vs., 334–335 mural ameloblastoma, 533 salivary gland anlage tumor, 104–106 oncocytoma vs., 295–299 odonto-ameloblastoma, 551–553 benign peripheral nerve sheath tumors papillary cystic variant, vs. cystade- peripheral ameloblastoma, 534 (BPNST), 40–44 noma, 316–317 unicystic ameloblastoma, 532–533 benign sinonasal tract neoplasia, 28–48 salivary glands, 353–359 aneurysmal bone cyst (ABC), 584 benign peripheral nerve sheath tumor, adenocarcinoma not otherwise specified central GCRG vs., 590–591 40–44 (ANOS), 389–390 angiocentric T-cell lymphoma, 81 meningioma, 37–40 adenoid cystic carcinoma (ACC) angiomatoid/angioectatic polyps vs. JNAF, nasal glial heterotopia (NGH), 44–48 adenomatoid odontogenic tumor vs., 100–104 oncocytic Schneiderian papilloma 545 angiosarcoma vs. Kaposi’s sarcoma, 206 (OSP), 5, 33–36 basal cell adenocarcinoma vs., 372 antrochoanal polyp, 5–8 Schneiderian inverted papilloma, 28–32 basal cell adenoma vs., 293 apical periodontal cyst, 510–512 bisphosphonate osteonecrosis (BPP), canalicular adenoma vs., 294 arytenoid chondrosarcomas, 241 565–566 neuroendocrine carcinoma vs., 240–241 atrophic oral lichen planus, 126 blastomas of salivary glands, 319–325 atypical adenoma vs. parathyroid