Cutaneous Melanoma Solid Tumor Rules
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Orbital Involvement with Desmoplastic Melanoma*
Br J Ophthalmol: first published as 10.1136/bjo.71.4.279 on 1 April 1987. Downloaded from British Journal of Ophthalmology, 1987, 71, 279-284 Orbital involvement with desmoplastic melanoma* JERRY A SHIELDS,'4 DAVID ELDER,2 VIOLETTA ARBIZO,4 THOMAS HEDGES,' AND JAMES J AUGSBURGER' From the 'Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, the 'Pigmented Lesion Group, Department of Dermatology and of Pathology and Laboratory Medicine, University of Pennsylvawa, the 'Department of Ophthalmology, Pennsylvania Hospital, and the 4Pathology Department, Wills Eye Hospital, USA. SUMMARY A 79-year-old woman developed an orbital mass five and a half years after excision of a cutaneous melanoma from the side of the nose. The initial orbital biopsy was interpreted histopathologically as a malignant fibrous histiocytoma, but special stains and electron microscopy showed it to be a desmoplastic malignant melanoma which had apparently spread to the orbit from the prioriskin lesion by neurotropic mechanisms. The occurrence of a desmoplastic neurotropic melanoma in the orbit has not been previously recognised. The problems in the clinical and pathological diagnosis of this rare type of melanoma are discussed. Orbital involvement with malignant melanoma most August 1984 she had excision of scar tissue around often occurs secondary to extrascleral extension the left eye and biopsy of a 'cyst' in the left upper of posteribr uveal melanoma.' Primary orbital eyelid, which was diagnosed at another hospital as a melanoma and metastatic cutaneous melanoma malignant fibrous histiocytoma. http://bjo.bmj.com/ to the orbit are extremely rare.2 Desmoplastic A general physical examination gave essentially melanoma is a rare form of cutaneous melanoma normal results, and complete examination of the which can extend from a superficial location into the right eye revealed no abnormalities. -
Acral Compound Nevus SJ Yun S Korea
University of Pennsylvania, Founded by Ben Franklin in 1740 Disclosures Consultant for Myriad Genetics and for SciBase (might try to sell you a book, as well) Multidimensional Pathway Classification of Melanocytic Tumors WHO 4th Edition, 2018 Epidemiologic, Clinical, Histologic and Genomic Aspects of Melanoma David E. Elder, MB ChB, FRCPA University of Pennsylvania, Philadelphia, PA, USA Napa, May, 2018 3rd Edition, 2006 Malignant Melanoma • A malignant tumor of melanocytes • Not all melanomas are the same – variation in: – Epidemiology – risk factors, populations – Cell/Site of origin – Precursors – Clinical morphology – Microscopic morphology – Simulants – Genomic abnormalities Incidence of Melanoma D.M. Parkin et al. CSD/Site-Related Classification • Bastian’s CSD/Site-Related Classification (Taxonomy) of Melanoma – “The guiding principles for distinguishing taxa are genetic alterations that arise early during progression; clinical or histologic features of the primary tumor; characteristics of the host, such as age of onset, ethnicity, and skin type; and the role of environmental factors such as UV radiation.” Bastian 2015 Epithelium associated Site High UV Low UV Glabrous Mucosa Benign Acquired Spitz nevus nevus Atypical Dysplastic Spitz Borderline nevus tumor High Desmopl. Low-CSD Spitzoid Acral Mucosal Malignant CSD melanoma melanoma melanoma melanoma melanoma 105 Point mutations 103 Structural Rearrangements 2018 WHO Classification of Melanoma • Integrates Epidemiologic, Genomic, Clinical and Histopathologic Features • Assists -
Short Course 11 Pigmented Lesions of the Skin
Rev Esp Patol 1999; Vol. 32, N~ 3: 447-453 © Prous Science, SA. © Sociedad Espafiola de Anatomfa Patol6gica Short Course 11 © Sociedad Espafiola de Citologia Pigmented lesions of the skin Chairperson F Contreras Spain Ca-chairpersons S McNutt USA and P McKee, USA. Problematic melanocytic nevi melanin pigment is often evident. Frequently, however, the lesion is solely intradermal when it may be confused with a fibrohistiocytic RH. McKee and F.R.C. Path tumor, particularly epithelloid cell fibrous histiocytoma (4). It is typi- cally composed of epitheliold nevus cells with abundant eosinophilic Brigham and Women’s Hospital, Harvard Medical School, Boston, cytoplasm and large, round, to oval vesicular nuclei containing pro- USA. minent eosinophilic nucleoli. Intranuclear cytoplasmic pseudoinclu- sions are common and mitotic figures are occasionally present. The nevus cells which are embedded in a dense, sclerotic connective tis- Whether the diagnosis of any particular nevus is problematic or not sue stroma, usually show maturation with depth. Less frequently the nevus is composed solely of spindle cells which may result in confu- depends upon a variety of factors, including the experience and enthusiasm of the pathologist, the nature of the specimen (shave vs. sion with atrophic fibrous histiocytoma. Desmoplastic nevus can be distinguished from epithelloid fibrous histiocytoma by its paucicellu- punch vs. excisional), the quality of the sections (and their staining), larity, absence of even a focal storiform growth pattern and SiQO pro- the hour of the day or day of the week in addition to the problems relating to the ever-increasing range of histological variants that we tein/HMB 45 expression. -
Melanocytic Lesions of the Face—SW Mccarthy & RA Scolyer 3 Review Article
Melanocytic Lesions of the Face—SW McCarthy & RA Scolyer 3 Review Article Melanocytic Lesions of the Face: Diagnostic Pitfalls* 1,2 1,2 SW McCarthy, MBBS, FRCPA, RA Scolyer, MBBS, FRCPA Abstract The pathologist often has a difficult task in evaluating melanocytic lesions. For lesions involving the face the consequences of misdiagnosis are compounded for both cosmetic and therapeutic reasons. In this article, the pathological features of common and uncommon benign and malignant melanocytic lesions are reviewed and pitfalls in their diagnosis are highlighted. Benign lesions resembling melanomas include regenerating naevus, “irritated” naevus, com- bined naevus, “ancient naevus”, Spitz naevus, dysplastic naevus, halo naevus, variants of blue naevi, balloon and clear cell naevi, neurotised naevus and desmoplastic naevus. Melanomas that can easily be missed on presentation include desmoplastic, naevoid, regressed, myxoid and metastatic types as well as so-called malignant blue naevi. Pathological clues to benign lesions include good symmetry, V-shaped silhouette, absent epidermal invasion, uniform cellularity, deep maturation, absent or rare dermal mitoses and clustered Kamino bodies. Features more commonly present in melanomas include asymmetry, peripheral epidermal invasion, heavy or “dusty” pigmentation, deep and abnormal dermal mitoses, HMB45 positivity in deep dermal melanocytes, vascular invasion, neurotropism and satellites. Familiarity with the spectrum of melanocytic lesions and knowledge of the important distinguishing features should -
Melanoma: Epidemiology, Risk Factors, Pathogenesis, Diagnosis and Classification
in vivo 28: 1005-1012 (2014) Review Melanoma: Epidemiology, Risk Factors, Pathogenesis, Diagnosis and Classification MARCO RASTRELLI1, SAVERIA TROPEA1, CARLO RICCARDO ROSSI2 and MAURO ALAIBAC3 1Melanoma and Sarcoma Unit, Veneto Institute of Oncology, IOV- IRCCS, Padova, Italy; 2Melanoma and Sarcoma Unit, Veneto Institute of Oncology, IOV-IRCCS and Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy; 3Dermatology Unit, University of Padova, Padova, Italy Abstract. This article reviews epidemiology, risk factors, Epidemiology pathogenesis and diagnosis of melanoma. Data on melanoma from the majority of countries show a rapid At the start of 21st century, melanoma remains a potentially increase of the incidence of this cancer, with a slowing of fatal malignancy. At a time when the incidence of many the rate of incidence in the period 1990-2000. Males are tumor types is decreasing, melanoma incidence continues to approximately 1.5-times more likely to develop melanoma increase (1). Although most patients have localized disease than females, while according to other studies, the different at the time of the diagnosis and are treated by surgical prevalence in both sexes must be analyzed in relation with excision of the primary tumor, many patients develop age: the incidence rate of melanoma is grater in women metastases (2). than men until they reach the age of 40 years, however, by The incidence of malignant melanoma has been increasing 75 years of age, the incidence is almost 3-times as high in worldwide, resulting in an important socio-economic men versus women. The most important and potentially problem. From being a rare cancer one century ago, the modifiable environmental risk factor for developing average lifetime risk for melanoma has now reached 1 in 50 malignant melanoma is the exposure to ultraviolet (UV) in many Western populations (3). -
Optimal Management of Common Acquired Melanocytic Nevi (Moles): Current Perspectives
Clinical, Cosmetic and Investigational Dermatology Dovepress open access to scientific and medical research Open Access Full Text Article REVIEW Optimal management of common acquired melanocytic nevi (moles): current perspectives Kabir Sardana Abstract: Although common acquired melanocytic nevi are largely benign, they are probably Payal Chakravarty one of the most common indications for cosmetic surgery encountered by dermatologists. With Khushbu Goel recent advances, noninvasive tools can largely determine the potential for malignancy, although they cannot supplant histology. Although surgical shave excision with its myriad modifications Department of Dermatology and STD, Maulana Azad Medical College and has been in vogue for decades, the lack of an adequate histological sample, the largely blind Lok Nayak Hospital, New Delhi, Delhi, nature of the procedure, and the possibility of recurrence are persisting issues. Pigment-specific India lasers were initially used in the Q-switched mode, which was based on the thermal relaxation time of the melanocyte (size 7 µm; 1 µsec), which is not the primary target in melanocytic nevus. The cluster of nevus cells (100 µm) probably lends itself to treatment with a millisecond laser rather than a nanosecond laser. Thus, normal mode pigment-specific lasers and pulsed ablative lasers (CO2/erbium [Er]:yttrium aluminum garnet [YAG]) are more suited to treat acquired melanocytic nevi. The complexities of treating this disorder can be overcome by following a structured approach by using lasers that achieve the appropriate depth to treat the three subtypes of nevi: junctional, compound, and dermal. Thus, junctional nevi respond to Q-switched/normal mode pigment lasers, where for the compound and dermal nevi, pulsed ablative laser (CO2/ Er:YAG) may be needed. -
Types of Melanoma
Types of Melanoma Melanoma is classified into different types. Classification is based on their colour, shape, location, and how they grow. Superficial spreading melanoma Superficial spreading melanoma usually looks like a dark brown or black stain spreading from an existing or a new mole. This type of melanoma is more commonly seen in areas of skin that have been exposed to UV light, especially areas of previous sunburn. It is the most common type, making up 70% of melanomas. Superficial spreading melanoma tends to follow the ABCDE rules. In most situations, the early changes are purely visual ones and it is the later stages that may result in symptoms (itching or bleeding). In addition to the skin surfaces, melanoma can also present in mucosal surfaces such as the mouth or genital area. Nodular melanoma Nodular melanoma is a firm, domed bump. It grows quickly down through the epidermis into the dermis. Once there, it can metastasize, or spread to other parts of the body. Nodular melanoma makes up about 10% of all melanomas. Nodular melanoma is typically dark brown or black, may crust or ulcerate. As in all sub-types of melanoma, nodular melanoma can present without any colour or a pink, red or skin toned colour (amelanotic), especially in people with very fair complexions. Lentigo maligna melanoma Lentigo maligna melanoma looks like a dark stain which may have looked initially like a large or irregular freckle. It has an uneven border and irregular colour. It is usually seen on the face or arms of middle aged and older people. -
On the Histological Diagnosis and Prognosis of Malignant Melanoma
J Clin Pathol: first published as 10.1136/jcp.33.2.101 on 1 February 1980. Downloaded from J Clin Pathol 1980, 33: 101-124 On the histological diagnosis and prognosis of malignant melanoma ARNOLD LEVENE Hunterian Professor, Royal College of Surgeons, and Department of Histopathology, The Royal Marsden Hospital, Fulham Road, London SW3, UK SUMMARY This review deals with difficulties of diagnosis in cutaneous malignant melanoma encountered by histopathologists of variable seniority and is based on referred material at The Royal Marsden Hospital over a 20-year period and on the experience of more than two-and-a-half thousand cases referred to The World Health Organisation Melanoma Unit which I reviewed when chairman of the Pathologists' Committee. Though there is reference to the differential diagnosis of primary and metastatic tumour, the main concern is with establishing the diagnosis of primary melanoma to the exclusion of all other lesions. An appendix on recommended diagnostic methods in cutaneous melanomas is included. Among the difficult diagnostic fields in histopathol- not to be labelled malignant because it 'looks nasty'. ogy melanocytic tumours have achieved a notoriety. Thus, until the critical evaluation of the 'malignant Accurate diagnosis, however, is of major clinical melanoma of childhood' by Spitz (1948) the naevus importance for the following reasons: with which this investigator's name is associated was 1 The management of the primary lesion is reckoned among the malignancies on histological principally by surgical excision with a large margin grounds. of normal appearing skin. The consequences of over-diagnosis are those of major disfiguring surgery Naevus and melanoma cells http://jcp.bmj.com/ and its morbidity. -
Identification of HRAS Mutations and Absence of GNAQ Or GNA11
Modern Pathology (2013) 26, 1320–1328 1320 & 2013 USCAP, Inc All rights reserved 0893-3952/13 $32.00 Identification of HRAS mutations and absence of GNAQ or GNA11 mutations in deep penetrating nevi Ryan P Bender1, Matthew J McGinniss2, Paula Esmay1, Elsa F Velazquez3,4 and Julie DR Reimann3,4 1Caris Life Sciences, Phoenix, AZ, USA; 2Genoptix Medical Laboratory, Carlsbad, CA, USA; 3Dermatopathology Division, Miraca Life Sciences Research Institute, Newton, MA, USA and 4Department of Dermatology, Tufts Medical Center, Boston, MA, USA HRAS is mutated in B15% of Spitz nevi, and GNAQ or GNA11 is mutated in blue nevi (46–83% and B7% respectively). Epithelioid blue nevi and deep penetrating nevi show features of both blue nevi (intradermal location, pigmentation) and Spitz nevi (epithelioid morphology). Epithelioid blue nevi and deep penetrating nevi can also show overlapping features with melanoma, posing a diagnostic challenge. Although epithelioid blue nevi are considered blue nevic variants, no GNAQ or GNA11 mutations have been reported. Classification of deep penetrating nevi as blue nevic variants has also been proposed, however, no GNAQ or GNA11 mutations have been reported and none have been tested for HRAS mutations. To better characterize these tumors, we performed mutational analysis for GNAQ, GNA11, and HRAS, with blue nevi and Spitz nevi as controls. Within deep penetrating nevi, none demonstrated GNAQ or GNA11 mutations (0/38). However, 6% revealed HRAS mutation (2/32). Twenty percent of epithelioid blue nevi contained a GNAQ mutation (2/10), while none displayed GNA11 or HRAS mutation. Eighty-seven percent of blue nevi contained a GNAQ mutation (26/30), 4% a GNA11 mutation (1/28), and none an HRAS mutation. -
Prevalence of Melanoma Clinically Resembling Seborrheic Keratosis Analysis of 9204 Cases
STUDY Prevalence of Melanoma Clinically Resembling Seborrheic Keratosis Analysis of 9204 Cases Leonid Izikson, BS; Arthur J. Sober, MD; Martin C. Mihm, Jr, MD, FRCP; Artur Zembowicz, MD, PhD Objective: To estimate the prevalence of melanoma clini- Main Outcome Measure: Histological diagnosis, which cally mimicking seborrheic keratosis. was correlated with the preoperative clinical diagnosis. Design: Retrospective review of cases submitted for his- Results: Melanoma was identified in 61 cases (0.66%) tological examination with a clinical diagnosis of sebor- submitted for histological examination with a clinical rheic keratosis or with a differential diagnosis that in- diagnosis that included seborrheic keratosis. Melanoma cluded seborrheic keratosis. was in the clinical differential diagnosis of 31 cases (51%). The remaining lesions had a differential diagno- Setting: A tertiary medical care center–based der- sis of seborrheic keratosis vs melanocytic nevus (17 matopathology laboratory serving academic der- cases, 28%), basal cell carcinoma (7 cases, 12%), or a squa- matology clinics that have a busy pigmented lesion mous proliferation (3 cases, 5%). In 3 cases (5%), seb- clinic. orrheic keratosis was the only clinical diagnosis. All histological types of melanoma were represented. Materials and Methods: A total of 9204 consecutive pathology reports containing a diagnosis of seborrheic Conclusions: Our results confirm that melanoma can keratosis in the clinical information field were identi- mimic seborrheic keratosis. These data strongly support fied between the years 1992 and 2001 through a com- the current policy of submitting for histological examina- puter database search. Reports with a final histological tion all specimens that have been removed from patients. diagnosis of melanoma were selected for further review and clinicopathological analysis. -
Lumps & Bumps: Approach to Common Dermatologic Neoplasms
Case-Based Approach to Common Dermatologic Neoplasms Patrick Retterbush, MD, FAAD Mohs Surgery & Dermatologic Oncology Associate Member of the American College of Mohs Surgery Private Practice: Lockman Dermatology January 27th 2018 Disclosure of Relevant Financial Relationships • I do not have any relevant financial relationships, commercial interests, and/or conflicts of interest regarding the content of this presentation. Goals/Objectives • Recognize common benign growths • Recognize common malignant growths • Useful clues & examination for evaluating melanocytic nevi and when to be concerned for melanoma/atypical moles • How to perform a basic skin biopsy and which method/type to choose • Basic treatment/when to refer Key Questions & Physical Examination Findings for a Growth History Physical Examination • How long has the lesion been • Describing a growth present? – flat or raised? • flat – macule (<1cm) or patch (>1cm) – years, months, weeks • raised – papule (<1cm) or plaque (>1cm) – nodule if deep (majority of lesion in • Has it changed? dermis/SQ) – Size – secondary descriptive features • scaly (hyperkeratosis, retention of strateum – Shape corneum) – Color • crusty (dried serum, blood, or pus on surface) • eroded or ulcerated (partial vs. full thickness – Symptoms – pain, bleeding, itch? epidermal loss) – Over what time frame? • color (skin colored, red, pigmented, pearly) • feel (hard or soft, mobile or fixed) • PMH: • size: i.e. 6 x 4mm – prior skin cancers • Look at the rest of the skin/region of skin • SCC/BCCs vs. melanoma -
Molecular Diagnostics for Ambiguous Melanocytic Tumors Hilmy Shahbain, BS,* Chelsea Cooper, BA,† and Pedram Gerami, MD‡
Molecular Diagnostics for Ambiguous Melanocytic Tumors Hilmy Shahbain, BS,* Chelsea Cooper, BA,† and Pedram Gerami, MD‡ Certain subsets of melanocytic neoplasms are difficult to classify because of conflicting histologic features and the existence of a poorly defined intermediate grade of melanocytic tumors. The integration of molecular diagnostic information with a histologic impression may contribute signif- icantly toward improving classification. This review discusses the development of and advances in molecular techniques, including comparative genomic hybridization and fluorescence in situ hy- bridization (FISH) as diagnostic and prognostic tools for melanocytic neoplasms. Further, we discuss how specific molecular aberrations identified via FISH correlate with certain morphologies in melanocytic neoplasms. We also examine the prognostic value of FISH in intermediate-grade melanocytic tumors, particularly atypical Spitz tumors. Semin Cutan Med Surg 31:274-278 © 2012 Frontline Medical Communications KEYWORDS fluorescence in situ hybridization, FISH, melanoma, Spitz nevi, Spitz tumor he vast majority of conventional melanomas and mela- atypia with clinical behavior identical to that of similarly Tnocytic nevi may be readily classified as entirely benign staged conventional melanomas.5 or malignant using standard microscopy. However, there are 2. The presence of an intermediate grade of melanocytic tu- at least 2 distinct factors responsible for the diagnostic dis- mors shows frequent involvement of sentinel lymph crepancy and uncertainty that dermatopathologists face nodes with significantly less, but occasional, disease pro- when dealing with certain subsets of melanocytic tumors:1-3 gression beyond the sentinel lymph node.6,7 The existence of intermediate-grade melanocytic neoplasms is generally 1. Some lesions that are completely benign or entirely malig- gaining acceptance among the dermatopathology nant in their biologic potential have ambiguous histologic community.8 features that make proper classification difficult.