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Name Research Interest General research topics or Available datasets have a Available sets of biospecimens specific ongoing projects resident could use for that that a resident could us for available on which a resident research research could collaborate Planning Sonalkar, Sarita, MD, -Postpartum family planning in -Mobile applications in family -Second trimester uterine -N/A MPH domestic and international planning, interventions for evacuation dataset settings pain management in and contraception -Implementation of family care, systematic reviews, planning interventions at the increasing contraception point of care access in subspecialty -Post abortion contraception

-Abortion stigma Gyn Oncology Drapkin, Ronny, MD, -The Drapkin laboratory -Whole exome -RNA Seq data -The Penn Ovarian Cancer PhD focuses on developing a characterization of precursors Research Center houses the comprehensive understanding in the fallopian tube -ChIP Seq data ‘Living Tissue Bank’. This of the genetic, molecular and facility banks fresh physiological factors that drive -Targeting Cyclin E in ovarian -Reverse Phase tumor/normal tissues as well as the development of cancer, cancer (mechanism and animal biological fluids. with a special focus on models) -Protein Array (RPPA) data gynecologic malignancies. -Clinically annotated tissue Recent work from our group -PAX8 as a lineage specific microarray and others has implicated the transcription factor for the fallopian tube (FT) secretory reproductive tract cell as the likely cell-of-origin (ChIP-Seq, RNA Seq, protein for a majority of high-grade complex) serous ovarian carcinomas. This new concept of ovarian -Dysregulation of epigenetic tumorigenesis has been a marks drive metabolic paradigm shift in the field and perturbations in ovarian the Drapkin lab has been at the cancer forefront in developing novel experimental platforms that -CRABP2 as a novel biomarker address the role of the FT for ovarian cancer epithelium and its susceptibility to neoplastic -BRCA mouse models of transformation. These ovarian cancers derived from platforms include genetically the fallopian tube engineered mouse (GEM) models, fallopian tube-derived cell lines, and patient-derived tumor xenografts. The lab is currently focused on utilizing these models to interrogate how genetic and epigenetic alterations influence lineage dependencies, genomic instability, DNA repair, replicative stress, and metabolism. The goal is to define selective vulnerabilities that can guide novel therapeutic approaches and biomarker development. Haggerty, Ashley E., - Quality improvement - Continuing to develop the - NSQIP -N/A MD, MSCE Penn - Obesity and endometrial database, a warehouse for all - SEER/Medicare cancer cancer patients since 2009 (needing to be - Endometrial cancer continuously updated) database (Penn) including surgical data, treatment/complication - Longitudinal prospective data, medical co-morbidities, survey in a subset of vital statistics. endometrial cancer patients (Penn) Ko, Emily M., MD, -Primary Research Interests: -Gynecologic Oncology: -SEER Medicare -N/A MSCR sciences research Focus on endometrial, uterine, including observational studies cervical cancer associated -PENN endometrial database utilizing administrative claims treatments, risk factors and /Penn Cancer Registry data sources, cancer registries, outcomes including medical institutional data sources and surgical management -National Surgical Quality Improvement Program -Secondary Research: clinical -Quality and Outcomes/ (NSQIP) pharmacologic and services: including practice interventional trials patterns; access; clinical -National Cancer Database pathways; payment reform (NCDB) -Research topics: gynecologic oncology with focus on -Use of national data sources -Collaboration through endometrial cancer; cancer as well as institutional data Wharton/Leonard Davis risk factors; quality and health sources Institute as a Senior Fellow: service outcomes; clinical HCUP, NIS, OPTUM pharmacologic and -Gynecology/Surgery: interventional trials Preinvasive disease: lower genital tract dysplasia (, -Research methods: etc.) ; pharmacoepidemiology; health -Surgery: modality, outcomes services; clinical trial conduct -Teaching/ assessments Powell, Daniel J., PhD - Immunobiology of -Tumor infiltrating lymphocyte - Clinically annotated tissue - A viable tumor cell bank with a gynecologic cancer and functions in the presence of microarrays for IHC focus on resected ovarian testing the application of specific immune modulatory interrogations cancer; viably stored tumor immune-based therapy for antibodies and/or cancer. pharmacologic agents.

- Rare tumor-reactive T cells - CAR T cell studies from tumor infiltrating lymphocyte populations in - Studies on immune various cancers utilizing novel suppressor elements in the culture conditions and T cell tumor microenvironment capture techniques in order to rationally design future clinical studies. - Generating de novo tumor- reactive T cells through a variety of genetic engineering methods, primarily through the use of chimeric antigen receptors (CARs). Clinical studies are planned.

Tanyi, Janos, MD, PhD -CAR-T cell therapy or ovarian -OTL 38 fluorescence -Excel database of over 500 -Around 200 serum samples cancer intraoperative imaging for patient received Doxil from patient with benign and better debulking for ovarian chemotherapy malignant ovarian masses and -Early detection of ovarian cancer around 50 serum samples from cancer -Excel database of over 100 normal control women -Comparison the effectiveness ovarian cancer patient -Vaccine immunotherapy of of RECIST and irRS in received Bevacizumab ovarian cancer immunotherapy trial patients treatment

Zhang, Lin, MD - Non-coding RNAs to women’s -Circulating noncoding RNA as A large-scale human lncRNA -N/A cancer initiation and an early detection biomarker database was developed progression. -Development of for gynecological cancers. recently in Zhang lab: bioinformatic methods and The Cancer LncRNome Atlas databases for lncRNA studies. -Pre-clinical development of http://tcla.fcgportal.org/ epigenetic drugs targeting -Identification of the cancer gynecological cancers. driver lncRNA genes. -Meta-analysis on women’s -Evaluation of lncRNA-based diseases with focus on cancer diagnosis (biomarkers) and or cancer-related diseases. treatments (druggable targets) for patients with cancer.

MFM Dugoff, Lorraine, MD -Cell-free DNA and adverse -Cell-free DNA fetal fraction -PoPPS and PoPPT datasets -First trimester maternal obstetric outcome and adverse obstetric outcome (RCT pessary trial in women plasma, serum and buffy white with mid trimester short coat specimens from 1000+ -Prediction of first trimester -Prediction of preterm birth cervix; women with well-characterized preeclampsia and other database includes cervical outcomes adverse obstetric outcome length, pregnancy outcomes in singletons and twins) -First trimester screening for aneuploidy -Cell-free DNA fetal fraction and obstetric outcomes (3500+ women)

-First trimester prediction of adverse obstetric outcome (1000+ women-1st trimester ultrasound (uterine artery Doppler and placental volumes), screening results, pregnancy outcomes--very well characterized) Durnwald, Celeste, MD -Diabetes in pregnancy, -Diabetes in pregnancy -Intensive Behavioral -N/A Education Program for GDM -Obesity in -Obesity in pregnancy women pregnancy -Breastfeeding -Breastfeeding Elovitz, Michal, MD -Preterm birth -Preterm birth: cohort and -Motherhood and -See attached translational studies Microbiome (2000 singleton -Microbiome cohort) -Existing clinical databases -Preeclampsia focused on preterm birth and -Biomarker study (1100 other adverse pregnancy cohort with PTL) outcomes -STOP (600 cohort with PTL) Levine, Lisa D., MD, -Induction of labor and labor -Induction of labor and labor -800-person cohort of -N/A MSCE management management women with 2 within the Penn system – -Hypertensive disorders -Hypertensive disorders retrospectively collected - pregnancy pregnancy includes all labor and delivery information with -Preeclampsia and -Preeclampsia and maternal and neonatal cardiovascular health – both in cardiovascular health – both in outcomes for both the immediate postpartum the immediate postpartum pregnancies period period and long-term and long-term -490 women enrolled in the FOR MOMI RCT along with -Cardiac disease and -Cardiac disease and 380 women whose data was pregnancy pregnancy collected prospectively as the - and maternal -Global health and maternal observational group – this morbidity and obstetrical care morbidity and obstetrical care includes all induction, labor, and delivery information with maternal and neonatal outcomes

-300-person cohort of women with severe preeclampsia – labor and delivery information as well as comprehensive maternal outcomes and postpartum follow-up

-400-person cohort of women at high risk for preterm birth – includes antenatal/ information along with labor and delivery outcomes Parry, Samuel I., MD -Preterm birth prevention -PDF listing the MFMU -March of Dimes Preterm -March of Dimes Preterm Birth secondary studies; Birth Research Center - case- Research Center - case-control -Placental dysfunction control study (CRIB, preterm study (CRIB, preterm births, -Secondary analysis proposal births, term births) - biospeceimens -Viral infections in pregnancy template; and term births) - biospeceimens and clinical data are available and clinical data are available -List of MFMU publications through March 2016. The deadline for secondary study proposals utilizing the BCC for data analysis is February; requests for data discs to perform other secondary studies may be submitted at any time. Secondary studies are strongly encouraged, and the MFMU investigators (Sehdev, Srinivas, Dugoff, Elovitz, and Parry) would be delighted to work with you to develop a secondary study. Look through the list of completed studies for ideas.

Schwartz, Nadav L., - Ultrasound-based research - Mining the ultrasound -Prospective cohort of ~800 - Maternal serum at ~11-14 and MD database to address any singletons with clinical 16-18 weeks on prospective - Prenatal diagnosis clinically relevant and outcomes already collected singleton cohort interesting research question and 2nd trimester - Placental imaging serum available

-The clinical ultrasound database for all out obstetric ultrasounds in MFM

Simmons, Rebecca, MD -Molecular mechanisms that -Residents can participate in link an abnormal intrauterine any research project in our milieu (such as uteroplacental laboratory insufficiency, obesity, diabetes in pregnancy, and toxicant exposure) to the later development of obesity and type 2 diabetes in adulthood.

- Metabolic and mitochondrial dysfunction in the placenta plays in preterm birth. Srinivas, Sindhu K., -Hypertension in pregnancy -Studying and developing -PMC-Preeclampsia -N/A MD, MSCE obstetric quality measures mechanisms and -Cardiac disease and understanding the impact Consequences-case control of practice changes (individual study -Critical Care level and system level) on 440 women with PRE, 600 maternal and neonatal controls -Care at the threshold of outcomes viability -Cervix study-prospective -Understanding the etiology of cohort approximately 400 hypertensive disorders of women, two survey time pregnancy points –discrimination and system distrust -Evaluating new care delivery surveys; primary outcome models in the women with PTB pregnancy related hypertension

-Evaluating the etiology of health disparities in obstetric outcomes

Wang, Eileen, MD -Clinical obstetrics with -Simulation research topics/ -N/A -N/A ultrasound focus or simulation ultrasound growth focus performance

-Education research

REI Barnhart, Kurt T., MD, -Early pregnancy -Biomarkers for women with a -Large data base of women -Banked serum MSCE PUL at risk for ectopic pregnancy -Ectopic pregnancy followed until definitive specimen form women -Methotrexate for the diagnosis with early pregnancy - treatment of EP loss (biomarker -Large database of children -Outcome of children after -Health outcomes of women conceived after research) conception with infertility after infertility treatment treatment.

-How infertility affects health -Health outcomes of children after infertility treatment -Biomarkers

-Epidemiology

-Endocrinology

Butts, Samantha F., -Preconception health and -Preconception health and -Penn Ovarian Aging Study -- MD, MSCE reproductive outcomes, reproductive outcomes, currently this is the resource focusing on nutritional and focusing on nutritional and for Lilli Zimmerman's environmental exposures environmental exposures resident research project

-Preconception Vitamin D, -Preconception Vitamin D, A list of any sets of , reproductive fertility, reproductive biospecimens that you have outcomes. Performing outcomes. Performing that a resident could us for secondary analysis from large secondary analysis from large research completed randomized trials completed randomized trials Analysis of biospecimen Reproductive aging, Reproductive aging, from menopause, biomarkers, and menopause, biomarkers, and Network trials to determine consequences. Performing consequences. Performing association between secondary analysis of secondary analysis of preconception vitamin D population based cohort population based cohort status in 1200+ women, focusing on gene-environment focusing on gene-environment fertility and pregnancy interactions, chronic exposures interactions, chronic exposures outcomes. Analysis currently and outcomes. and outcomes. ongoing.

Dokras, Anuja, MD, Coutifaris, Christos, MD, PhD -Mood and anxiety disorders in -PCOS subjects and controls PhD PCOS available through the Penn Cardiovascular and metabolic biobank risk in PCOS Gerton, George, L. PhD -Mechanism of offspring sex -Sperm motility analysis in -PA Department of -Could analyze histology and ratio distortion caused by response to adenine Environmental Protection oil compare to tissues from paternal exposure to 2,3,7,8- nucleotides and and gas records untreated control mice tetrachlorodibenzodioxin pharmacological agents -PA Department of Health Sperm from treated animals: (TCDD, dioxin) statistics -Characterization of metabolic -Could perform multi-probe -Roles of adenine nucleotides pathways in sperm that do not -PA Department of fluorescent in situ hybridization (ATP, ADP, AMP, cAMP) is fit the canonical localizations Conservation and Natural to analyze sex chromosome regulating the flagellar Resources water use present in individual sperm waveforms of mammalian -GIS mapping and examination database spermatozoa of health effects -Could perform quantitative RT- -US Centers for Disease PCR to assess expression of -The use of geographic Control and Prevention specific genes in tissues from information systems (GIS) to databases TCCD-treated and control determine the impact of animals. unconventional gas development in the Marcellus Shale Region of Pennsylvania on health care utilization

-Role of progranulin on preimplantation embryo development and implantation (collaboration with MA Mainigi, MD)

Gracia, Clarisa R., MD, - and -Ovarian reserve and -ORACLE -Frozen serum and urinary MSCE reproductive capacity after reproductive capacity after samples in cancer survivors, cancer therapy cancer therapy -Ovarian reserve healthy controls and healthy late -Fertility preservation -Fertility preservation -Urinary Hormone reproductive age women

-Reproductive aging -Reproductive aging -Fertility preservation

-Surrogate measures of -Surrogate measures of -RHORS - late reproductive reproductive potential reproductive potential age women

Shah, Divya K., MD, -Medical education -Medical education -N/A -N/A MME -Outcomes in reproductive -Outcomes in reproductive surgery surgery

Urogynecology

Arya, Lily, MD -Overactive bladder -Brain imaging -Urgency study database -N/A

-Brain imaging for bladder and -Prevention of urinary -Falls study bowel control incontinence -Fecal incontinence study -Fecal incontinence -Using technology to improve database pelvic floor muscle anatomy care of older patients and

-Physical activity and urinary incontinence urinary and fecal incontinence in older women prevention of urinary incontinence

Andy, Uduak U., MD -Fecal Incontinence in women -Happy to mentor on any - data in women -N/A Urogyn-related project with and without FI -Pelvic floor disorders in Older women -Have some expertise in -Stool metabolites in women conducting qualitative studies with and without FI -Surgical outcomes in older women -Geriatric-related topics

-Qualitative studies in women with pelvic floor disorders

Gynecology James, Abike, MD, -Cervical Dysplasia -Not at this time, however if -N/A -N/A MPH the HPV vaccine study - HPV vaccine, proceeds I would be happy to collaborate on a resident with -Medical management of this. symptomatic fibroids. Salva, Catherine, MD -Educational research -LEADS study (multicenter LEADS study data -N/A study, leadership training for -Gyn surgery residents through simulation)

-Simulation

-Quality improvement