CEA CENTRE OF FONTENAY-AUX-ROSES KEY Zoé, a discovery gallery The hall of the Zoé reactor, transformed into a ACHIEVEMENTS 3 10 1 2 discovery gallery, displays these 10 key research projects conducted at the CEA of Fontenay-aux- Roses. This space is open to the public every 10-32-2667 / Certifié PEFC pefc-france.or g FROM 1946 TO TODAY… 1946 year during the European heritage days (Journées AT THE END OF THE WAR, THE CEA CENTRE européennes du patrimoine) or the national French OF FONTENAY-AUX-ROSES OPENED ITS event Science Fair (Fête de la science). DOORS WITH A MISSION: TO DEVELOP Group visits can also be organised on request.

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FONTENAY-AUX-ROSES.CEA.FR 5 Certified ISO 14001 (This norm relies on the principle of continuous improvement of the environmental performanceof the impacts induced by company activity) – Please do not litter. the control of the environmental Certified through ISO 14001 (This normrelies on the principle of continuous improvement

French Alternative Energies and French Alternative Energies and Atomic Energy Commission (CEA) Atomic Energy Commission (CEA) Centre de Fontenay-aux-Roses Centre de Fontenay-aux-Roses 18, route du Panorama – B.P. 6 18, route du Panorama – B.P. 6 92 265 Fontenay-aux-Roses Cedex 92 265 Fontenay-aux-Roses Cedex 1/ The Zoé reactor © Archives CEA 2 / Maurice Surdin, Frédéric Joliot–Curie and Lew Kowarski next to the Zoé control room © Archives CEA 3 / Removing radioelements from the Zoé reactor © Archives CEA France France 4 / Prion diagnostic test © CEA/L.Godart 5 / The Triton reactor core © CEA/Pierre Jahan Planktonic A WORLD PREMIERE IN Red blood cells. organism. © Inserm TFR (TOKAMAK © M.Ormestad- THE FIGHT AGAINST A Kahikai-Tara- FONTENAY-AUX-ROSES), Oceans GENETIC BLOOD DISEASE THE FIRST FRENCH TOKAMAK In 2010 a patient with the most severe form of 40 MILLION NEW beta-thalassemia (a blood disease that affects A tokamak is a machine that can heat gases PLANKTONIC GENES 40,000 new-born babies in the world each year) to millions of degrees. The objective is to study was treated with a gene therapy developed at the possibility of producing energy by nuclear The Genoscope of Evry, attached to the CEA of the CEA of Fontenay-aux-Roses, in collaboration fusion, taking its inspiration from the reactions Fontenay-aux-Roses, is sequencing all of the plankton with Saint-Louis hospital, Necker hospital and the at the sun’s core. The TFR was in service from populations that were sampled during the worldwide company Bluebird Bio. Clinical trials are continuing Tracking gene therapy targets against The tokamak of Parkinson’s disease by teleradiography. Fontenay-aux-Roses 1973 to 1986, and obtained a world record Tara Oceans expedition. More than 40 million planktonic with success. © AP-HP in the 1980s. © CEA temperature of 20 million degrees in 1976. genes were thus discovered in 2015. These genes The CEA now pursues its fusion research at could be a source for new therapeutic molecules or Telemanipulation of Cadarache with the Tore Supra tokamak, and for industrial interest. the Maestro arm. © CEA the international project ITER. DISTINGUISHING THE ORIGIN OF CANCERS

TRITON, THE FIRST As the result of a collaboration between the CEA of ZOÉ, THE FIRST FRENCH THE WORLD’S BEST-SELLING FRENCH DISMANTLED Fontenay-aux-Roses, the Gustave Roussy Cancer NUCLEAR REACTOR “MAD COW DISEASE” TEST NUCLEAR REACTOR Center and the Pasteur hospital in Nice, genetic markers that were identified in 2011 and 2013 have The first French “atomic pile” was activated on In the midst of the mad cow disease crisis, researchers The complete dismantlement of Triton, an experimental made it possible to recognise the origin of certain December 15, 1948 at 12:12 pm. Named Zoé at the CEA of Fontenay-aux-Roses and Saclay nuclear reactor that was in service at Fontenay-aux-Roses cancers, such as thyroid cancer. These “signatures” (Zéro énergie, zero energy– Oxyde d’uranium, uranium developed in several months a diagnostic test for prions, from 1959 to 1982, was completed in 2004. This event was allow to distinguish between spontaneous tumours oxide – Eau lourde, heavy water), this reactor was the agent of this disease. This test has been used in the first of its kind in France. The decomissioning technical and those caused by radiotherapy or a nuclear operated until 1976 for the study of physics and slaughterhouses since 2001 to remove sick animals from operations that were performed have made it possible accident (i.e. radio-induced). nuclear materials, to calibrate detectors and measuring the food industry. The aim of this is to avoid transmission today to accommodate research facilities for infectious instruments, to supply radioelements for medicine and of prions to humans, in whom it induces a variant of diseases and innovative therapies on this site. science, to train personnel in piloting reactors, and to the neurodegenerative Creutzfeldt-Jakob disease. help lay the foundations of radioprotection. This was the most widely adopted test in the world, with more than 60% of the global market. PUREX, A PROCESS MAESTRO, THE FIRST ROBOT FOR RECYCLING ARM THAT IS RESISTANT A WORLD PREMIERE NUCLEAR FUEL

TO RADIOACTIVITY IN THE FIGHT AGAINST Microscopy section of a thyroid gland invaded by a PARKINSON’S DISEASE PUREX (Plutonium Uranium Refining by Extraction) is a malignant tumour. © CEA Maestro is an articulated “arm” ending in a multifunction chemical process devised in the United States, which “hand” that has been designed to resist extremely strong In 2014, fifteen people with Parkinson’s disease were able makes it possible to extract uranium and plutonium radioactivity. Developed in large part at Fontenay-aux- to recover a large part of the control over their movements, from spent nuclear fuel. The uranium and plutonium are Roses in collaboration with IFREMER and the company thanks to an innovative therapy developed in collaboration then reused to produce energy, by being recycled into Cybernetix, Maestro was put into service in 2015. This between the CEA centre of Fontenay-aux-Roses, new fuels. The CEA of Fontenay-aux-Roses has worked arm makes it possible to intervene wherever the level of the Henri Mondor hospital of Créteil, the University Paris-Est on this process since 1954 in order to industrialize it. radioactivity prevents access by workers, and can be Créteil and the company Oxford Biomedica. Research is PUREX has thus been used in the reprocessing plant used to disassemble, cut, measure, decontaminate, etc. ongoing in order to further improve the process. of La Hague since 1967. Pulsed column in the PUREX process. © P. Stroppa/CEA