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Physiologist Physiologist Published by The American Physiological Society Integrating the Life Sciences from Molecule to Organism The PhysiologistPhysiologist 2010 Walter C. Randall Lecture in Biomedical Ethics Scientific Integrity: Positive & Negative Academic/Industry INSIDE Relationships Debra A. Schwinn ACDP Meeting Univ. of Washington, Seattle Highlights Introduction to the with the American p. 14 Randall Lectureship Physiological Walter C. Randall Society to honor (1916-1993) was a physi- Randall with the Williams Honored at ologist who began his Randall ACDP Meeting career as a biology major Lectureship in p. 15 at Taylor Univ., where he Biomedical Ethics. graduated in 1938. After receiving his MS and PhD Introduction to Highlights of the in physiology from Purdue the 2010 Randall 2010 USA Science Univ., and completing a Lecturer and Engineering postdoctoral fellowship at As a cardiovas- Case Western Reserve cular clinician and Festival Univ., Randall spent an researcher, as well p. 19 illustrious career as an as Chair of a large academic scientist, culmi- clinical depart- nating during the last 21 ment at the Univ. Dual Science years as Chairman of the Debra A. Schwinn of Washington, it Couples and Being Department of Physiology was an honor to be a New Faculty at the Loyola Univ. selected to give the Chicago Stritch School of Medicine. He 2010 Randall Lecture in Biomedical Member was actively involved with the Ethics. In terms of background, my p. 22 American Physiological Society his area of scientific research focuses on entire career. stress responses in humans, particu- APS Leadership After retiring, Randall returned to larly responses to the robust stress of his roots at Taylor Univ., where he con- surgery. It is in this context that after Meets with NIH tinued mentoring summer science stu- medical school, anesthesiology resi- Officials dents with their cardiovascular dency, and cardiothoracic anesthesiol- p. 24 research projects. As a man with deep ogy clinical fellowship, I began basic Christian beliefs and commitment, science molecular pharmacology/phys- Randall emphasized the combination iology training focusing on α1-adren- Experimental of integrity, scientific expertise, and ergic receptors in the laboratory of Biology 2011 rigor with all his students. Students Robert J. Lefkowitz at Duke Univ. and colleagues also remember Randall Over the last 25 years, my career has Program Schedule as a very humble man. It is in his mem- included cloning cDNAs, pharmaco- p. 28 ory that Taylor Univ. has partnered logically characterizing encoded pro- (continued on page 3) Volume 54, No. 1 - February 2011 www.the-aps.org 1 Published bimonthly and distributed by The American Physiological TheThe Society PhysiologistPhysiologist 9650 Rockville Pike Bethesda, Maryland 20814-3991 ISSN 0031-9376 Peter D. Wagner President Contents Gary C. Sieck Past President Joey P. Granger President-Elect 2010 Walter C. Randall Lecture Mentoring Forum Martin Frank in Biomedical Ethics Dual Science Couples and Being Editor and Executive Director Scientific Integrity: Positive & a New Faculty Member Councillors Kenneth M. Baldwin, Negative: Academic/Industry Angela J. Grippo 22 David P. Brooks, Relationships Ida Llewellyn-Smith, Gordon S. Mitchell, Debra A. Schwinn 1 Science Policy Frank L. Powell, Usha Raj, American Physiological Society Linda C. Samuelson, Curt D. Sigmund, Alan F. Sved From the President’s Desk 9 Condemns Threats Against Researchers 24 Ex Officio Pamela K. Carmines, A Matter of Opinion American Physiological Society John C. Chatham, The More Things Change... 11 Statement Condemning J.R. Haywood, Ronald M. Lynch, Thomas A. Pressley, Threats Against Researchers 24 Hershel Raff, APS News APS Leadership Meets Jeff M. Sands APS Council Holds Fall Council with NIH Officials 24 Publications Committee: Chair: Meeting in Chantilly, VA 12 NIH Board Approves Plan Hershel Raff; Members: Kim E. Barrett, William Chilian, Asrar to Create New Center 25 Malik, David Pollock, Helen E. ACDP Meeting Highlights European Union to Implement Raybould, Celia Sladek. Director of Publications: Rita Scheman. Association of Chairs of New Animal Welfare Rules Design and Copy Editor: Joelle R. Departments of Physiology in 2013 26 Grossnickle. Meeting Highlights 14 International Scientists Commit Subscriptions: Distributed to members as part of their member- Williams Honored at to Advocate for Animal Research 26 ship. Nonmembers in the USA Annual ACDP Meeting 15 Reference Handbook on Clinical (print only): individuals $85.00; Signs in Rodents and Rabbits institutions $135.00. Nonmembers in Canada: individuals $125.00; Membership Available 27 institutions $170.00. Nonmembers New Undergraduate Student elsewhere: individuals $125.00; institutions $170.00. Single copies Members 16 Experimental Biology 2011 and back issues when available, New Graduate Student Members 16 Program Schedule 28 $20.00 each; single copies and back issues of Abstracts issues when New Affiliate Members 17 available, $30.00. Subscribers to Positions Available 33 The Physiologist also receive abstracts of the Conferences of the Education American Physiological Society. APS Presents Awards at the Annual People & Places The online version is available free to all worldwide. Biomedical Research Conference APS Members Weiss is New Dean The American Physiological Society for Minority Students 18 at Univ. of Texas 33 assumes no responsibility for the Highlights of the 2010 USA statements and opinions advanced by contributors to The Physiologist. Science and Engineering Festival 19 Senior Physiologists’ News 34 Please notify the APS Member- APS Archive of Teaching Resources ship Department as soon as Thanks its 2010 Reviewers 22 Book Review 35 possible if you change your address or telephone number. New Community is Coming Headquarters phone: 301-634-7118 to the APS Archive of The Wine Wizard 36 Fax: 301-634-7241 Teaching Resources 22 Email: [email protected] http://www.the-aps.org APS Membership Application 39 Printed in the USA 2 The Physiologist 2010 Randall Lecture Vol. 54, No. 1, 2011 teins, and studying regulation for sev- cial) conflict of interest will be explored publication “help.” (39) In this context, eral new α1-adrenergic receptor sub- for both clinical and basic science what is appropriate and what is not? types, as well as defining the physiolog- research. Second, non-traditional con- Definitions: Rewards, financial or ic and pharmacologic consequences of flicts of interest will be examined. otherwise, raise the question of what is naturally occurring human genetic These will be followed by examining the definition of “conflict of interest?” variants of these receptors. At a clini- the impact of world-view on ethical dis- Various dictionaries and websites cal level as a practicing anesthesiolo- cernment and how this relates to deci- define conflict of interest as the follow- gist, I enjoyed partnering with a won- sions made (unwittingly or consciously) ing: derful group of collaborating faculty to in the arena of conflict of interest. • “situations where decisions are define the new field of perioperative influenced by personal interest” genomics, an area of clinical genetics Importance of Academic & • “multiple interests—one of which that examines the role of genetic vari- Industrial Relationships could corrupt another” ability in predicting adverse events fol- Many key discoveries in science and • “someone in a position of trust has lowing patient outcome after surgery. medicine have resulted from academ- interests other than the common good” My interest in bioethical issues began ic/industrial partnerships, including • “using influence for personal gain.” early when I participated on an ethics both medical and therapeutic Based on these definitions it is clear committee that defined “Perioperative advances. Several authors have recent- that balance is key. Academic/industry Do Not Resuscitate” guidelines for ly commented that there is no inherent relationships provide support and Duke Univ. Medical Center and pub- conflict of interest in principle for funding for important research ques- lished guidelines in this area for prac- physicians or scientists working with tions. Such funding has the potential ticing clinicians in the operating room. industry or government since there is a to enhance creativity, facilitate devel- This was followed later by fellowship commonality of interest that is opment of more important (and per- training in bioethics and genetics dur- “healthy, desirable, and beneficial.” (8, haps higher risk) projects, facilitate ing a sabbatical at the National 15) Industry/academic collaboration expert consultation, provide more rapid Human Genome Research Institute in and partnerships are sought by both advances and more publications, plus 2000, including a project on patient parties and expected by Congress! the possibility of commercialization. attitudes on biorepositories. More Indeed, Congress has encouraged tech- However, some possible unintended recently, I participated in the Institute nology transfer by facilitating consequences might include restrictive of Medicine Committee on Organ patentability of life science research covenants (secrecy agreements), cul- Donation that recommended “Donation since the 1980s (7). Specifically, the ture clash (knowledge versus profit), after Cardiac Death” criteria that have Bayh-Dole Act of 1980 gives universi- suppression of negative findings, and since been initiated nationwide. In ties almost exclusive rights to intellec- possible
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