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(12) United States Patent (10) Patent No.: US 9,333,159 B2 Hayes (45) Date of Patent: May 10, 2016

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(12) United States Patent (10) Patent No.: US 9,333,159 B2 Hayes (45) Date of Patent: May 10, 2016 US009333 159B2 (12) United States Patent (10) Patent No.: US 9,333,159 B2 Hayes (45) Date of Patent: May 10, 2016 (54) TOPCAL DNA REPAIR COMPOSITION (58) Field of Classification Search None (75) Inventor: Barbara F. Hayes, New York, NY (US) See application file for complete search history. (73) Assignee: PHOTOMEDEX, INC., Horsham, PA (56) References Cited (US) U.S. PATENT DOCUMENTS (*) Notice: Subject to any disclaimer, the term of this patent is extended or adjusted under 35 2004/OO57917 A1 3, 2004 Wolfetal. 2006/0002884 A1 1/2006 Golz-Berner et al. .......... 424/74 U.S.C. 154(b) by 0 days. 2007/0207195 A1* 9, 2007 Yarosh et al. ................. 424/450 2007/025.4021 A1 11/2007 Scimeca et al. (21) Appl. No.: 14/114,651 2009.0117060 A1 5/2009 Golz-Berner et al. 2010, O291190 A1 11/2010 Giampapa (22) PCT Fled: Apr. 26, 2012 FOREIGN PATENT DOCUMENTS (86) PCT NO.: DE 4244418 A1 * T 1993 S371 (c)(1), DE 20316269 2, 2005 (2), (4) Date: Aug. 4, 2014 EP 1634,576 3, 2006 WO 2008/OO2609 1, 2008 (87) PCT Pub. No.: WO2O12/149110 WO 2009/023416 2, 2009 PCT Pub. Date: Nov. 1, 2012 OTHER PUBLICATIONS Prior Publication Data Merck Manual Home Edition, Overview of Sunlight and Skin Dam (65) age, accessed on Jun. 26, 2015, pp. 1-3. US 2014/0335137 A1 Nov. 13, 2014 Goihman-Yahr, Skin aging and photoaging: an outlook, Clinics in Dermatology 14: 153-160, 1996.* Related U.S. Application Data Tyrrell, Solar UV damage and skin protection: the boosting of natural defences and healing by cosmeceuticals. Bulletin Technique Gat (60) Provisional application No. 61/481,123, filed on Apr. tefosse (2013), 106, 72-81.* 29, 2011. Tanaka, Protecting skin photoaging by NF-kappaB inhibitor. Current drug metabolism, (Jun. 1, 2010) vol. 11, No. 5, pp. 431-435.* (51) Int. C. Goh, The treatment of visible signs of Senescence: the Asian experi A6 IK36/00 (2006.01) ence. The British journal of dermatology, (Apr. 1990) vol. 122 Suppl A6 IK 8/66 (2006.01) 35, pp. 105-109.* A6 IK 36/31 (2006.01) International Search Report, Australian Patent Office, Application No. PCT/US2012/035124, Jul 27, 2012. A6 IK 8/27 (2006.01) International Written Opinion, Australian Patent Office, Application A6 IK 8/29 (2006.01) No. PCT/US2012/035124, Jul 27, 2012. A61O 1704 (2006.01) European Extended Search Report, European Patent Office, A 6LX8/99 (2006.01) Co-pending European National Phase Application No. 12776676.4. A6 IK 8/14 (2006.01) Nov. 28, 2014. A6 IK 8/49 (2006.01) A61O 19/00 (2006.01) * cited by examiner A 6LX8/97 (2006.01) A6 IK S/37 (2006.01) Primary Examiner — Qiuwen Mi A61O 19/08 (2006.01) (74) Attorney, Agent, or Firm — Gottlieb, Rackman & (52) U.S. C. Reisman, PC CPC. A61K 8/66 (2013.01); A61K 8/14 (2013.01); A61K 8/27 (2013.01); A61 K8/29 (2013.01); (57) ABSTRACT A61K 8/37 (2013.01); A61 K8/4946 (2013.01); Provided herein are topical compositions for repairing Sun A61K 8/975 (2013.01); A61K 8/99 (2013.01); damaged skin and topical Sunscreen compositions for both A61K 36/31 (2013.01); A61O 1704 (2013.01); preventing and repairing Sun damage. A61O 19/00 (2013.01); A61O 19/004 (2013.01); A61O 19/08 (2013.01) 5 Claims, 6 Drawing Sheets U.S. Patent May 10, 2016 Sheet 1 of 6 US 9,333,159 B2 FG. localized Pigmentation - | f | start week 4 4. WKRESS >20% Reduction in localized Pigmentation U.S. Patent May 10, 2016 Sheet 2 of 6 US 9,333,159 B2 FG. 2 Pores SS S. Š Star S S a WEEK RESS YSO Redictio; if Cies U.S. Patent May 10, 2016 Sheet 3 of 6 US 9,333,159 B2 F.G. 3 exture S 8 S S SS S Week 4 Start Week 4 4. WEEK RESS >40% improvement in texture U.S. Patent May 10, 2016 Sheet 4 of 6 US 9,333,159 B2 F.G. 4 Stat S 5 4.0 mmrer a 3.5 i 3.0" 25 -3. is 2.0 as S 15 3s ea 1.10 ...'...'rxxxxxxxxxxxx isSir 'O.C. -Estart weeksE. 8 AK RSS >50% Rediction if Wrikes U.S. Patent May 10, 2016 Sheet 5 of 6 US 9,333,159 B2 F.G. 5 Wrinkies r is a an 2 is . ss 5 : a ra ...is Fr..) is 0. 8 WWEEK RESS >35%, Rediction Wrikes U.S. Patent May 10, 2016 Sheet 6 of 6 US 9,333,159 B2 F.G. 6 Under-Eye Circles Comparative Analysis Prews ostreatment left Eye Facebo Week 8 Right Eye feated Week 8 US 9,333,159 B2 1. 2 TOPCAL DNAREPAIR COMPOSITION In an additional aspect, the aforementioned embodiments include a cyanobacteria extract derived from plankton. In the RELATED APPLICATIONS same aspect, the cyanobacteria is Anacystis nidulans. In the same aspect, the Anacystis nidulans extract contains photol This application claims priority to U.S. Provisional Appli yase. cation No. 61/481,123, filed Apr. 29, 2011. Where permitted, In yet another aspect, the aforementioned embodiments this application is incorporated by reference in its entirety. include Micrococcus luteus extract. In the same aspect, the Micrococcus luteus extract contains UV endonuclease. TECHNICAL FIELD In various aspects of the aforementioned embodiments, the 10 metal binding site comprises at least two amino acids selected Embodiments provided herein relate generally to the fields from Arg, His, and Lys. In the same aspect, the peptide con of cosmetics and dermatology industries, and more specifi sists of 3 amino acids. Further in the same aspect, the 3 amino cally to compositions for repairing Sun damage to the skin. acids have the sequence Gly-His-Lys. In another aspect, the 3 amino acids have the sequence Ala-His-Lys. BACKGROUND 15 In various aspects of the aforementioned embodiments, the metal atom is copper (II), cadmium (II), tin (II), cobalt(II), Exposure to ultraviolet (UV) radiation from sunlight can iron(II), or manganese(II). In the same aspect, the metal atom cause a variety of skin conditions including cosmetic defects is copper(II). Such as discoloration, pore formation, age spots, spider veins, In various aspects of the aforementioned embodiments, the and rough texture, as well as serious diseases such as skin liposomes comprise phospholipids, oleic acid, and choles cancer. Sun exposure can also lead to the appearance of pre terol. In one aspect, the liposomes are about 200 nm in diam mature aging by causing the skinto lose its elasticity and form eter. wrinkles. In another embodiment, a topical composition for repair Various topical creams, lotions, and ointments have been ing Sun damaged skin includes one or more DNA repair made in an attempt to address the negative effects of Sun 25 enzymes selected from the group consisting of photolyase damage on the skin either by prevention or treatment. How from Anacystis nidulans, UV endonuclease from Micrococ ever, preventive topical compositions such as conventional cus luteus, and OGG1 from Arabidopsis thaliana; liposomes Sunscreens are inadequate because they typically wash or rub containing said one or more DNA repair enzymes; a peptone off, require frequent re-application, and are not properly or or synthesized peptide comprising a metal atom binding site; thoroughly applied. Nevertheless, even with proper applica 30 a metal atom bound to said metal binding site; and a topically tion of common Sunscreens, UV exposure and DNA damage suitable carrier. can still occur despite a high sun protection factor (SPF). In one aspect, the one or more enzymes are recombinantly Similarly, conventional topical compositions for treating Sun expressed. In the same aspect, the one or more recombinantly damaged skin are inadequate and fail to address the multiple expressed enzymes are purified by chromatography. complex cellular levels impacted by sun exposure. Such defi 35 In various aspects of the aforementioned embodiment, the cient conventional products are limited to addressing only a metal binding site comprises at least two amino acids selected single cellular aspect of the complex cascade of cellular dam from Arg, His, and Lys. age caused by Sun exposure. In various aspects of the aforementioned embodiment, the metal binding site comprises at least two amino acids selected SUMMARY 40 from Arg, His, and Lys. In the same aspect, the peptide con sists of 3 amino acids. Further in the same aspect, the 3 amino In one embodiment, a topical composition for repairing Sun acids have the sequence Gly-His-Lys. In another aspect, the 3 damaged skin includes one or more plant, algae, or bacteria amino acids have the sequence Ala-His-Lys. extracts; liposomes containing at least a portion of said one or In various aspects of the aforementioned embodiment, the more extracts; a peptone or synthesized peptide comprising a 45 metal atom is copper (II), cadmium (II), tin (II), cobalt(II), metal atom binding site; a metal atom bound to said metal iron(II), or manganese(II). In the same aspect, the metal atom binding site; and a topically suitable carrier. In another is copper(II). embodiment, a topical composition for repairing Sun dam In various aspects of the aforementioned embodiment, the aged skin includes one or more DNA repair enzyme-contain liposomes comprise phospholipids, oleic acid, and choles ing extracts; liposomes containing at least a portion of said 50 terol. In one aspect, the liposomes are about 200 nm in diam one or more extracts; a peptide bound to a metal atom; and a eter. topically suitable carrier. Without intending to be bound by In an additional embodiment, a Sunscreen composition for theory, in such embodiments the user benefits from simulta preventing and repairing Sun damage to skin includes one or neity of the independent, but mutually adjuvant and non more algae or bacteria extracts; liposomes containing at least internecine, actions of the peptide orpeptone and the enzyme.
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