Molecules 2013, 18, 10870-10900; doi:10.3390/molecules180910870 OPEN ACCESS molecules ISSN 1420-3049 www.mdpi.com/journal/molecules Review Italian Chemists’ Contributions to Named Reactions in † Organic Synthesis: An Historical Perspective Gianluca Papeo 1,* and Maurizio Pulici 2,* 1 Department of Medicinal Chemistry, Nerviano Medical Sciences srl, Business Unit Oncology, Viale Pasteur 10, Nerviano 20014, MI, Italy 2 Department of Chemical Core Technologies, Nerviano Medical Sciences srl, Business Unit Oncology, Viale Pasteur 10, Nerviano 20014, MI, Italy † Dedicated to the memory of Professor Giulio Natta on the occasion of the 50th anniversary of his Nobel Prize award. * Authors to whom correspondence should be addressed; E-Mails:
[email protected] (G.P.);
[email protected] (M.P.). Received: 6 August 2013; in revised form: 29 August 2013 / Accepted: 30 August 2013 / Published: 4 September 2013 Abstract: From the second half of the 19th century up to modern times, the tremendous contribution of Italian chemists to the development of science resulted in the discovery of a number of innovative chemical transformations. These reactions were subsequently christened according to their inventors’ name and so entered into the organic chemistry portfolio of “named organic reactions”. As these discoveries were being conceived, massive social, political and geographical changes in these chemists’ homeland were also occurring. In this review, a brief survey of known (and some lesser known) named organic reactions discovered by Italian chemists, along with their historical contextualization, is presented. Keywords: Italian chemists; named reactions; history of chemistry Molecules 2013, 18 10871 1. Introduction At some point in the history of organic chemistry, someone arbitrarily decided to christen a certain chemical transformation after its discoverer’s name.