Platelet Product Administration Safety

ERC: 100404 Platelet administration Platelet • • • • group? blood Which 1 Blood compatibility and platelet • Leucocyte depleted and suspendedin plasma • • • platelets Apheresis • • Pooled platelets Platelet products Patient st

negative negative negative negative positive positive positive positive choice may reduce the risk of hemolysis If ABO compatible transfusion is unavoidable then the use of pooled platelets in additive solution based on this table If the is ideal not available the Blood bank scientist will the select bestavailable next platelet product are immunocompromised and patients receiving intensive chemotherapy receive can Positive Rh NegativeRh Immuno COMPETENT patients should receive NEGATIVE Rh donation. Patients who for guide of alternative groups or phone RCH questions Blood Bank with further 5829 identical plateletABO and(D) Rh products are preferable but not always available. table See above irradiated are Service) Blood Cross Red (Australian ARCBS from products platelet All are often available in paediatric splits of 4or 8(40 Collected from asingle donor viaapheresis bag (adult 100 collecting the platelets and returning the other of parts the blood to the donor. Apheresis involves removing the donor’s blood, spinning it in apheresis an machine, and asmall amount of plasma Leucocyte depleted and suspendedin predominately platelet additive solution (PAS) pooled together to form one unit (>160mls) plateletsThe are collected from anumber of donations (4 separate these are donors) then AB AB O O B B A A Pack type most preferable positive 1 O * * * * * st *Check negative 3 1 O * * * * rd st with blood positive bank 3 1 A * * * * * * rd st

negative 2 2 3 3 1 A * * * nd nd rd rd st

low titre O Pos 2 3 3 * * * * * nd rd rd – 60mls) low titre O Neg 2 2 2 * * * * * nd nd nd –

Apheresis donations400mls). positive 1 B * * * * * * * st negative 2 3 3 1 B * * * * nd rd rd st positive AB 1 * st negative AB 2 1 nd st • • What is anappropriate dose of platelets? • Transfusion safety • Platelet storage Platelet • observations Platelet transfusion product • • • Administering platelets only a portion of the pack/unit will be required to a maximum vol 10mL/kg of to a maximum required be will pack/unit the of aportion only children small and To infants excess to neonates, volume avoid giving Dose is usually based on number of packs/units according to above) (see product types See they must within becommenced 30minutes of leaving the blood bank Platelets are stored at 20 See Can beadministered over 30minutes –2hours, but must becompleted within 4hours If giving several paedi paks each donation number should beadministered separately Use anew blood administration filter administering when platelets Platelet product (Volume >160mL–anadultdose) (Volume >100ml–anadultdose)

Platelets apheresis paediatric blood blood (Each partisanadultdose) Platelets pooledinPAS Leucocyte depleted Leucocyte depleted Leucocyte depleted Leucocyte depleted Part 1,2,3,or4of Platelets apheresis Platelets apheresis Vlm 40 –50mL) (Volume

Part 1or2of

product administraton administration Irradiated Irradiated Irradiated Irradiated If apaediatricaphersissplitisnotavailable usethefollowingguide Patient weight

administration

poster – poster 24°C on aplatelet agitator. They expire 5days after collection, 1 10ml/kg MAX MAX MAX pack ever <10kg 10ml/kg 10ml/kg 10ml/kg is or which less MAX

2 MAX MAX MAX safety paedi 10 –20kg 10ml/kg 10ml/kg 10ml/kg packs 3 MAX MAX MAX paedi 20 –30kg 10ml/kg 10ml/kg 10ml/kg packs 1 1 1 10ml/kg 10ml/kg 10ml/kg 4 pack pack ever pack ever ever paedi 30 –40kg is is is or or or packs which which which less less less MAX MAX MAX

4 paedi >40kg 1 1 1 packs