Sulfur Containing Pharmaceuticals Created by the Njardarson Group (The University of Arizona): Edon Vitaku, Elizabeth A. Ilardi, Jón T. Njarðarson

Magnesium Sulfate Disulfiram Thiopental Heparin Streptozol Sulfadiazine M&B Sotradecol Propylthiouracil Bacitracin Azulfidine Benemid Selsun Phenergan Promethazine/Cod Phenergan Vc/Cod Purinethol Thiosulfil Myleran Phenylephr/Promethaz Compazine Promazine Diuril Thorazine Trilafon Diabinese Chlorprothixene Naturetin Permitil Neptazane Anturane Stelazine ( Magnesium Sulfate ) ( Disulfiram ) ( Thiopental ) ( Heparin) ( Sulfanilamide ) ( Sulfadiazine ) ( Sulfapyridine ) ( Sodium tetradecyl sulfate ) ( Propylthiouracil ) ( Bacitracin ) ( Sulfasalazine ) ( Probenecid ) ( Selenium Sulfide ) ( Promethazine ) ( Codeine & Promethazine ) ( Codeine, Phenylephrine & Promethazine ) ( Mercaptopurine ) ( Sulfamethizole ) ( Busulfan ) ( Phenylephrine & Promethazine ) ( Prochlorperazine ) ( Promazine ) ( Chlorothiazide ) ( Chlorpromazine ) ( Perphenazine ) ( Chlorpropamide ) ( Chlorprothixene ) ( Bendroflumethiazide ) ( Fluphenazine ) ( Methazolamide ) ( Sulfinpyrazone ) ( Trifluoperazine )

DER/ALM` NERVOUS SYSTEM NERVOUS SYSTEM CAR/SEN/BBO AIN/DER AIN/DER ANTI-INFECTIVE CARDIOVASCULAR ENDOCRINE SYSTEM DER/RES ALM/DER MUSCULO-SKELETAL DERMATOLOGICAL DER/RES/NER RESPIRATORY SYSTEM RESPIRATORY SYSTEM ONCOLOGICAL DER/BBO/AIN/SEN ONCOLOGICAL RESPIRATORY SYSTEM NERVOUS SYSTEM NERVOUS SYSTEM CARDIOVASCULAR NERVOUS SYSTEM NERVOUS SYSTEM ALIMENTARY TRACT & METABOLISM NERVOUS SYSTEM CARDIOVASCULAR NERVOUS SYSTEM SENSORY ORGAN MUSCULO-SKELETAL NERVOUS SYSTEM` Approved 1900* Approved 1920 Approved 1934 Approved 1935* Approved 1937* Approved 1941* Approved 1942 Approved 1946 Approved 1948 Approved 1948* Approved 1950* Approved 1951 Approved 1951 Approved 1951* Approved 1952 Approved 1952 Approved 1953 Approved 1953* Approved 1954 Approved 1954 Approved 1956 Approved 1956 Approved 1957 Approved 1957 Approved 1957 Approved 1958 Approved 1958 Approved 1959 Approved 1959 Approved 1959 Approved 1959 Approved 1959

Hydrochlorothiazide Trancopal Doburil Enduron Daranide Blephamide S.O.P. Torecan Orinase Aldoril Mellaril Dymelor Triavil Dyazide Omnipen Lasix Versapen-K Thioguanine Tolinase Imuran Pathocil Acetophenazine Cleocin Floxapen Serentil Sulfacel-15 Gliclazide Penicillin G Polysporin Keflex Oxacillin Veetids Blenoxane ( Hydrochlorothiazide ) ( Chlormezanone ) ( Cyclothiazide ) ( Methyclothiazide ) ( Diclofenamide ) ( Prednisolone Acetate & Sulfacetamide ) ( Thiethylperazine ) ( Tolbutamide ) ( Methyldopa & Hydrochlorothiazide ) ( Thioridazine ) ( Acetohexamide ) ( Amitriptyline & Perphenazine ) ( Triamterene & Hydrochlorothiazide ) ( Ampicillin ) ( Furosemide ) ( Hetacillin ) ( Thioguanine ) ( Tolazamide ) ( Azathioprine ) ( Dicloxacillin ) ( Acetophenazine ) ( Clindamycin ) ( Flucloxacillin ) ( Mesoridazine ) ( Sulfacetamide ) ( Gliclazide ) ( Penicillin G ) ( Bacitracin, Neomycin & Polymyxin B ) ( Cephalexin ) ( Oxacillin ) ( Penicillin V ) ( Bleomycin )

CAR`/END MUSCULO-SKELETAL CARDIOVASCULAR CARDIOVASCULAR SENSORY ORGAN AIN/SEN RESPIRATORY SYSTEM ALIMENTARY TRACT & METABOLISM CARDIOVASCULAR NERVOUS SYSTEM ALIMENTARY TRACT & METABOLISM NERVOUS SYSTEM CARDIOVASCULAR AIN/SEN CARDIOVASCULAR ANTI-INFECTIVE ONCOLOGICAL ALIMENTARY TRACT & METABOLISM END/ONC ANTI-INFECTIVE NERVOUS SYSTEM ANTI-INFECTIVE ANTI-INFECTIVE NERVOUS SYSTEM SENSORY ORGAN ALIMENTARY TRACT & METABOLISM SEN/AIN DERMATOLOGICAL ANTI-INFECTIVE ANTI-INFECTIVE ANTI-INFECTIVE ONCOLOGICAL Approved 1959* Approved 1960 Approved 1960 Approved 1960 Approved 1960s Approved 1961 Approved 1961 Approved 1961 Approved 1962 Approved 1962 Approved 1964 Approved 1965 Approved 1965 Approved 1965* Approved 1966 Approved 1966 Approved 1966 Approved 1966 Approved 1968 Approved 1968 Approved 1970 Approved 1970 Approved 1970 Approved 1970 Approved 1970 Approved 1970s (IND) Approved 1970s* Approved 1971 Approved 1971 Approved 1971 Approved 1971 Approved 1973

Hyperstat Bactrim Trimox Bacitracin & Polymyxin B Cloxapen Monopril HCT Hyzaar Amsacrine Geocillin Tagamet Ranitidine Duricef Tacaryl Aldactazide Clinoril Sulpiride Premarin Rimso-50 Ceclor Pediazole Inderide Topiramate Tinactin Moduretic Claforan Pipracil Carafate Blocadren Aziocillin Metixene Mezlin Sulfamethoxazole ( Diazoxide ) ( Trimethoprim & Sulfamethoxazole ) ( Amoxicillin ) ( Bacitracin & Polymyxin B ) ( Cloxacillin ) ( Fosinopril & Hydrochlorothiazide ) ( Losartan & Hydrochlorothiazide ) ( Amsacrine ) ( Carbenicillin ) ( Cimetidine ) ( Ranitidine ) ( Cefadroxil ) ( Methdilazine ) ( Spironolactone & Hydrochlorothiazide ) ( Sulindac ) ( Sulpiride ) ( Conjugated Estrogens ) ( Dimethyl Sulfoxide ) ( Cefaclor ) ( Erythromycin Ethylsuccinate & Sulfisoxazole Acetyl ) ( Propranolol & Hydrochlorothiazide ) ( Topiramate ) ( Tolnaftate ) ( Amiloride & Hydrochlorothiazide ) ( Cefotaxime ) ( Piperacillin ) ( Sucralfate ) ( Timolol ) ( Azlocillin ) ( Metixene ) ( Mezlocillin ) ( Sulfamethoxazole )

CARDIOVASCULAR ANTI-INFECTIVE ANTI-INFECTIVE DERMATOLOGICAL ANTI-INFECTIVE CARDIOVASCULAR CARDIOVASCULAR ONCOLOGICAL ANTI-INFECTIVE ALIMENTARY TRACT & METABOLISM ALIMENTARY TRACT & METABOLISM ANTI-INFECTIVE RESPIRATORY SYSTEM CARDIOVASCULAR MUSCULO-SKELETAL NERVOUS SYSTEM GUS/ONC GUS/MSK ANTI-INFECTIVE SENSORY ORGAN CARDIOVASCULAR NERVOUS SYSTEM DERMATOLOGICAL CARDIOVASCULAR ANTI-INFECTIVE ANTI-INFECTIVE ALIMENTARY TRACT & METABOLISM CAR/SEN ANTI-INFECTIVE NERVOUS SYSTEM ANTI-INFECTIVE ANTI-INFECTIVE Approved 1973 Approved 1973 Approved 1974 Approved 1974 Approved 1974 Approved 1974 Approved 1975 Approved 1976 Approved 1977 Approved 1977 Approved 1977 Approved 1978 Approved 1978 Approved 1978 Approved 1978 Approved 1978 Approved 1978* Approved 1978* Approved 1979 Approved 1979 Approved 1979 Approved 1979 Approved 1980 Approved 1981 Approved 1981 Approved 1981 Approved 1981 Approved 1981* Approved 1982 Approved 1982 Approved 1982 Approved 1982

Cardizem Feldene Corzide Bumex Lozol Zinacef TZ-3 Tenoretic Precef Rocephin Mequitazine Lopressor HCT Capozide Glucotrol Femstat Fortaz Primaxin Timentin Trimeprazine Vaseretic Pepcid Unasyn Cayston Cefmax Mykrox Ceradon Axid Permax Profenal Metahydrin Suprax Zefazone ( Diltiazem ) ( Piroxicam ) ( Bendroflumethiazide & Nadolol ) ( Bumetanide ) ( Indapamide ) ( Cefuroxime ) ( Tioconazole ) ( Atenolol & Chlorthalidone ) ( Ceforanide ) ( Ceftriaxone ) ( Mequitazine ) ( Metoprolol & Hydrochlorothiazide ) ( Captopril & Hydrochlorothiazide ) ( Glipizide ) ( Butoconazole ) ( Ceftazidime ) ( Cilastatin & Imipenem ) ( Clavulanate & Ticarcillin ) ( Trimeprazine ) ( Enalapril & Hydrochlorothiazide ) ( Famotidine ) ( Sulbactam & Ampicillin ) ( Aztreonam ) ( Cefmenoxime ) ( Metolazone ) ( Cefotiam ) ( Nizatidine ) ( Pergolide ) ( Suprofen ) ( Trichlormethiazide ) ( Cefixime ) ( Cefmetazole )

CAR/END MSK`/SEN CARDIOVASCULAR CARDIOVASCULAR CARDIOVASCULAR AIN/RES DER/GUS CARDIOVASCULAR ANTI-INFECTIVE ANTI-INFECTIVE RESPIRATORY SYSTEM CARDIOVASCULAR CAR/END ALM/END GENITO-URINARY & SEX HOROMONE ANTI-INFECTIVE ANTI-INFECTIVE ANTI-INFECTIVE DERMATOLOGICAL CARDIOVASCULAR ALIMENTARY TRACT & METABOLISM ANTI-INFECTIVE AIN/ALM/RES ANTI-INFECTIVE CARDIOVASCULAR ANTI-INFECTIVE ALIMENTARY TRACT & METABOLISM NERVOUS SYSTEM MUSCULO-SKELETAL CARDIOVASCULAR ANTI-INFECTIVE ANTI-INFECTIVE Approved 1982* Approved 1982* Approved 1983 Approved 1983 Approved 1983 Approved 1983* Approved 1983* Approved 1984 Approved 1984 Approved 1984 Approved 1984 Approved 1984 Approved 1984* Approved 1984* Approved 1985 Approved 1985 Approved 1985 Approved 1985 Approved 1985 Approved 1986 Approved 1986 Approved 1986 Approved 1986* Approved 1987 Approved 1987 Approved 1988 Approved 1988 Approved 1988 Approved 1988 Approved 1988 Approved 1989 Approved 1989

Cefpiramide Prinzide Prilosec Torasemide Cefzil Tilid Carbimazole Sotalol Imitrex Ziac Zosyn Trusopt Remikiren Casodex Cedax Corvert Prevacid Rilutek Ethyol Prempro & Premphase Amaryl Epivir Soriatane DDAVP Teczem Tazorac Merrem ZyPREXA Pentosan Polysulfate Norvir Zanaflex Arfonad ( Cefpiramide ) ( Lisinopril & Hydrochlorothiazide ) ( Omeprazole ) ( Torasemide ) ( Cefprozil ) ( Ticlopidine ) ( Carbimazole ) ( Sotalol ) ( Sumatriptan ) ( Bisoprolol & Hydrochlorothiazide ) ( Piperacillin & Tazobactam ) ( Dorzolamide ) ( Remikiren ) ( Bicalutamide ) ( Ceftibuten ) ( Ibutilide ) ( Lansoprazole ) ( Riluzole ) ( Amifostine ) ( Conjugated Estrogens & Medroxyprogesterone ) ( Glimepiride ) ( Lamivudine ) ( Acitretin ) ( Desmopressin ) ( Elanapril & Diltiazem ) ( Tazorotine ) ( Meropenem ) ( Olanzapine ) ( Pentosan Polysulfate ) ( Ritonavir ) ( Tizanidine ) ( Trimethaphan )

ANTI-INFECTIVE CARDIOVASCULAR ALIMENTARY TRACT & METABOLISM CARDIOVASCULAR ANTI-INFECTIVE BLOOD & BLOOD FORMING ORGAN ENDOCRINE SYSTEM CARDIOVASCULAR NERVOUS SYSTEM CARDIOVASCULAR AIN/RES SENSORY ORGAN CARDIOVASCULAR ENDOCRINE SYSTEM RESPIRATORY SYSTEM CARDIOVASCULAR ALIMENTARY TRACT & METABOLISM NERVOUS SYSTEM END/GUS END/MSK/GUS ALM/END AIN/END DERMATOLOGICAL ENDOCRINE SYSTEM ENDOCRINE SYSTEM DERMATOLOGICAL ANTI-INFECTIVE NERVOUS SYSTEM CARDIOVASCULAR ANTI-INFECTIVE MUSCULO-SKELETAL CARDIOVASCULAR Approved 1989 Approved 1989 Approved 1989 Approved 1990 Approved 1991 Approved 1991 Approved 1992 Approved 1992 Approved 1992 Approved 1993 Approved 1993* Approved 1994 Approved 1994 Approved 1995 Approved 1995 Approved 1995 Approved 1995 Approved 1995 Approved 1995* Approved 1995* Approved 1995* Approved 1995* Approved 1996 Approved 1996 Approved 1996 Approved 1996 Approved 1996 Approved 1996 Approved 1996 Approved 1996 Approved 1996 Approved 1996

Accolate Augmentin Flovent Fertinex Omnicef Rescriptor Avalide Combivir Viracept Mirapex SEROquel Flomax Gabitril Zyflo Prevpac Plavix Teveten Glyburide Evista Acamprosate Azopt Cosopt Duloxetine Lovenox Provigil Amerge Tomudex Viagra Aggrastat Diovan HCT Celebrex Agenerase ( Zafirlukast ) ( Amoxicillin & Clavulanate ) ( Fluticasone Propionate ) ( Urofollitropin ) ( Cefdinir ) ( Delavirdine ) ( Irbesartan & Hydrochlorothiazide ) ( Lamivudine & Zidovudine ) ( Nelfinavir ) ( Pramipexole ) ( Quetiapine ) ( Tamsulosin ) ( Tiagabine ) ( Zileuton ) ( Amoxicillin, Clarithromycin & Lansoprazole ) ( Clopidogrel ) ( Eprosartan ) ( Glyburide ) ( Raloxifene ) ( Acamprosate ) ( Brinzolamide ) ( Dorzolamide & Timolol ) ( Duloxetine ) ( Enoxaparin ) ( Modafinil ) ( Naratriptan ) ( Raltitrexed ) ( Sildenafil ) ( Tirofiban ) ( Valsartan & Hydrochlorothiazide ) ( Celecoxib ) ( Amprenavir )

RESPIRATORY SYSTEM RES/AIN RES`/DER END/GUS ANTI-INFECTIVE ANTI-INFECTIVE CARDIOVASCULAR ANTI-INFECTIVE ANTI-INFECTIVE NERVOUS SYSTEM NERVOUS SYSTEM GENITO-URINARY & SEX HOROMONE NERVOUS SYSTEM RESPIRATORY SYSTEM ALM/AIN END/CAR END/CAR BBO/END END/GUS NERVOUS SYSTEM SENSORY ORGAN SENSORY ORGAN NERVOUS SYSTEM MUSCULO-SKELETAL NERVOUS SYSTEM NERVOUS SYSTEM ONCOLOGICAL GENITO-URINARY & SEX HOROMONE BLOOD & BLOOD FORMING ORGAN CARDIOVASCULAR ONC/MSK ANTI-INFECTIVE Approved 1996 Approved 1996* Approved 1996* Approved 1996* Approved 1997 Approved 1997 Approved 1997 Approved 1997 Approved 1997 Approved 1997 Approved 1997 Approved 1997 Approved 1997 Approved 1997 Approved 1997* Approved 1997* Approved 1997* Approved 1997* Approved 1997* Approved 1998 Approved 1998 Approved 1998 Approved 1998 Approved 1998 Approved 1998 Approved 1998 Approved 1998 Approved 1998 Approved 1998 Approved 1998 Approved 1998* Approved 1999

Fragmin Accuretic AcipHex Tykosin Zaditor ACTOS Avandia Trizivir Argatroban Septocaine Benzaclin Atacand HCT Cefazolin & Dextrose Advair HFA Glucovance Kaletra Mobic Tablet Protonix Zonegran Micardis HCT Innohep Axert Tracleer Spectracef Teveten HCT NexIUM Arixtra Geodon INVanz Bextra Relpax Faslodex ( Dalteparin ) ( Quinapril & Hydrochlorothiazide ) ( Rabeprazole ) ( Dofetilide ) ( Ketotifen ) ( Pioglitazone ) ( Rosiglitazone ) ( Abacavir, Lamivudine & Zidovudine ) ( Argatroban ) ( Articaine & Epinephrine ) ( Benzoyl Peroxide & Clindamycin ) ( Candesartan & Hydrochlorothiazide ) ( Cefazolin & Dextrose ) ( Fluticasone Propionate & Salmeterol ) ( Glyburide & Metformin ) ( Lopinavir & Ritonavir ) ( Meloxicam ) ( Pantoprazole ) ( Zonisamide ) ( Telmisartan & Hydrochlorothiazide ) ( Tinzaparin ) ( Almotriptan ) ( Bosentan ) ( Cefditoren Pivoxil ) ( Eprosartan & Hydrochlorothiazide ) ( Esomeprazole ) ( Fondaparinux ) ( Ziprasidone ) ( Ertapenem ) ( Valdecoxib ) ( Eletriptan ) ( Fulvestrant )

BLOOD & BLOOD FORMING ORGAN CARDIOVASCULAR ALIMENTARY TRACT & METABOLISM CAR/RES RES/SEN END/ALM END/ALM ANTI-INFECTIVE BLOOD & BLOOD FORMING ORGAN+ NERVOUS SYSTEM DERMATOLOGICAL CARDIOVASCULAR RESPIRATORY SYSTEM RESPIRATORY SYSTEM ALIMENTARY TRACT & METABOLISM ANTI-INFECTIVE MUSCULO-SKELETAL ALIMENTARY TRACT & METABOLISM NERVOUS SYSTEM CAR/END CAR/BBO NERVOUS SYSTEM CARDIOVASCULAR ANTI-INFECTIVE CARDIOVASCULAR ALIMENTARY TRACT & METABOLISM BLOOD & BLOOD FORMING ORGAN` NERVOUS SYSTEM AIN/GUS/RES GUS/MSK NERVOUS SYSTEM ENDOCRINE SYSTEM Approved 1999 Approved 1999 Approved 1999 Approved 1999* Approved 1999* Approved 1999* Approved 1999* Approved 2000 Approved 2000 Approved 2000 Approved 2000 Approved 2000 Approved 2000 Approved 2000 Approved 2000 Approved 2000 Approved 2000 Approved 2000 Approved 2000 Approved 2000* Approved 2000* Approved 2001 Approved 2001 Approved 2001 Approved 2001 Approved 2001 Approved 2001 Approved 2001 Approved 2001* Approved 2001* Approved 2002 Approved 2002

Metaglip Alinia Avandamet Emtriva Symbyax Prevacid Naprapac Benicar HCT Ertaczo Levitra Crestor Epzicom Truvada Zegerid Tindamax Spiriva HandiHaler Mycamine ACTOplus Met Aptivus Ziana Atripla Duetact Nuvigil Combigan Doribax Altabax Neupro Somatuline Depot Tekturna HCT Treximet Multaq Efient Istodax ( Glipizide & Metformin ) ( Nitazoxanide ) ( Metformin & Rosiglitazone ) ( Emtricitabine ) ( Fluoxetine & Olanzapine ) ( Lansoprazole & Naproxen ) ( Olmesartan & Hydrochlorothiazide ) ( Sertaconazole ) ( Vardenafil ) ( Rosuvastatin ) ( Abacavir & Lamivudine ) ( Emtricitabine & Tenofovir Disoproxil ) ( Omeprazole & Sodium Bicarbonate ) ( Tinidazole ) ( Tiotropium ) ( Micafungin ) ( Pioglitazone & Metformin ) ( Tipranavir ) ( Clindamycin & Tretinoin ) ( Emtricitabine, Tenofovir Disoproxil & Efavirenz ) ( Glimepiride & Pioglitazone) ( Armodafinil ) ( Brimonidine & Timolol ) ( Doripenem ) ( Retapamulin ) ( Rotigotine ) ( Lanreotide ) ( Aliskiren & Hydrochlorothiazide ) ( Naproxen & Sumatriptan ) ( Dronedarone ) ( Prasugrel ) ( Romidepsin )

ALIMENTARY TRACT & METABOLISM ALIMENTARY TRACT & METABOLISM ALM/END ANTI-INFECTIVE NERVOUS SYSTEM ALIMENTARY TRACT & METABOLISM CARDIOVASCULAR DERMATOLOGICAL GENITO-URINARY & SEX HOROMONE CAR/BBO ANTI-INFECTIVE ANTI-INFECTIVE ALIMENTARY TRACT & METABOLISM ANTI-INFECTIVE RESPIRATORY SYSTEM ANTI-INFECTIVE ENDOCRINE SYSTEM ANTI-INFECTIVE DERMATOLOGICAL ANTI-INFECTIVE ALIMENTARY TRACT & METABOLISM NERVOUS SYSTEM SENSORY ORGAN GENITO-URINARY & SEX HOROMONE DERMATOLOGICAL NER`/MSK END/MSK CARDIOVASCULAR NERVOUS SYSTEM CARDIOVASCULAR BBO/CAR BLOOD & BLOOD FORMING ORGAN Approved 2002 Approved 2002 Approved 2002* Approved 2003 Approved 2003 Approved 2003 Approved 2003 Approved 2003 Approved 2003 Approved 2003* Approved 2004 Approved 2004 Approved 2004 Approved 2004 Approved 2004 Approved 2005 Approved 2005 Approved 2005 Approved 2006 Approved 2006 Approved 2006 Approved 2007 Approved 2007 Approved 2007 Approved 2007 Approved 2007 Approved 2007* Approved 2008 Approved 2008 Approved 2009 Approved 2009 Approved 2009

Votrient Amturnide Latuda Tribenzor Teflaro Vimovo Complera Firazyr Xarelto Brilinta Duexis Zelboraf Tudorza Dymista Stribild Cystaran Myrbetriq Qsymia Surfaxin Erivedge Inlyta Xtandi BEACOPP ABVD ABVE ABVE-PC VeIP CATEGORY ABBREVIATIONS ( Pazopanib ) ( Aliskiren, Amlopidine & Hydrochlorothiazide ) ( Lurasidone ) ( Olmesartan Medoxomil, Amlopidine & Hydrochlorothiazide ) ( Ceftaroline ) ( Naproxen & Esomeprazole ) ( Emtricitabine, Rilpivirine & Tenofovir Disoproxil ) ( Icatibant ) ( Rivaroxaban ) ( Ticagrelor ) ( Ibuprofen & Famotidine ) ( Vemurafenib ) ( Aclidinium ) ( Azelastine & Fluticasone ) ( Cobicistat, Elvitegravir, Emtricitabine & Tenofovir Disoproxil ) ( Cysteamine ) ( Mirabegron ) ( Phentermine & Topriamate ) ( Sinapultide, DPPtdCho, POPG & Palmitic Acid ) ( Vismodegib ) ( Axitinib ) ( Enzalutamide ) ( Bleomycin, Etoposide, Doxorubicin, Cyclophosphamide, Vincristine, Procarbazine & Prednisone ) ( Doxorubicin, Bleomycin, Vinblastine & Dacarbazine ) ( Doxorubicin, Bleomycin, Vincristine & Etoposide ) ( Doxorubicin, Bleomycin, Vincristine, Etoposide, Prednisone & Cyclophosphamide ) ( Vinblastine, Ifosfamide, Cisplatin, & Mesna ) ALM ALIMENTARY TRACT & METABOLISM

AIN ANTI-INFECTIVE

BBO BLOOD & BLOOD FORMING ORGANS

CAR CARDIOVASCULAR SYSTEM

DER DERMATOLOGICAL

END ENDOCRINE SYSTEM

GUS GENITO-URINARY & SEX HORMONES

MSK MUSCULO-SKELETAL SYSTEM

NER NERVOUS SYSTEM

ONC ONCOLOGICAL

RES RESPIRATORY SYSTEM ALM/MSK CARDIOVASCULAR NERVOUS SYSTEM CARDIOVASCULAR AIN/DER/RES ALM/MSK ANTI-INFECTIVE DERMATOLOGICAL BLOOD & BLOOD FORMING ORGAN CARDIOVASCULAR ALM/MSK ONC/DER RESPIRATORY SYSTEM RESPIRATORY SYSTEM ANTI-INFECTIVE SENSORY ORGAN MUSCULO-SKELETAL ENDOCRINE SYSTEM RESPIRATORY SYSTEM ONCOLOGICAL ALM/ONC ALM/ONC ONCOLOGICAL ONCOLOGICAL ONCOLOGICAL ONCOLOGICAL ONCOLOGICAL Approved 2009* Approved 2010 Approved 2010 Approved 2010 Approved 2010* Approved 2010* Approved 2011 Approved 2011 Approved 2011 Approved 2011 Approved 2011* Approved 2011* Approved 2012 Approved 2012 Approved 2012 Approved 2012 Approved 2012 Approved 2012 Approved 2012 Approved 2012 Approved 2012* Approved 2012* Not Approved+ Not Approved+ Not Approved+ Not Approved+ Not Approved+ SEN SENSORY ORGANS

All drugs are considered FDA approved in the U.S. following the passage of the Pure Food and Drugs Act in 1906. http://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/ * The FDA approval year and Market Name is representative of the first three-letter abbreviation of the disease category (see legend) in the series. + This drug has also been FDA approved for additional disorders. ` According to the National Cancer Institute (http://www.cancer.gov), chemotherapy regimens do not have an official FDA approval, however, each individual molecular component is FDA approved.