Cardiovascular Drugs Created by the Njardarson Group (The University of Arizona): Edon Vitaku, Elizabeth A. Ilardi, Daniel J. Mack, Monica A. Fallon, Erik B. Gerlach, Miyant’e Y. Newton, Angela N. Yazzie, Jón T. Njarðarson

Ethanol Glyceryl Trinitrate Anestisine Quinidine Procaine Adrenaline Adenosine Phenylepherine Heparin Vasoxyl Sotradecol Xylocaine Pronestyl Betamethasone Catapres Cedilanide Dopamine Inversine Metaraminol Acetyldigitoxin Hydrocortisone ( Ethanol ) ( Nitroglycerin ) ( Benzocaine ) ( Quinidine ) ( Procaine ) ( Epinephrine ) ( Adenosine ) ( Phenylephrine ) ( Heparin ) ( Methoxamine ) ( Sodium Tetradecyl Sulfate ) ( Lidocaine ) ( Procainamide ) ( Betamethasone ) ( Clonidine ) ( Deslanoside ) ( Dopamine ) ( Mecamylamine ) ( Metaraminol ) ( Acetyldigitoxin ) ( Hydrocortisone )

VASOPROTECTIVE CARDIAC THERAPY VASOPROTECTIVE CARDIAC THERAPY VASOPROTECTIVE CARDIAC THERAPY CARDIAC THERAPY CARDIAC THERAPY VASOPROTECTIVE CARDIAC THERAPY VASOPROTECTIVE CARDIAC THERAPY CARDIAC THERAPY VASOPROTECTIVE ANTIHYPERTENSIVE CARDIAC THERAPY CARDIAC THERAPY ANTIHYPERTENSIVE CARDIAC THERAPY CARDIAC THERAPY VASOPROTECTIVE Approved 1700s Approved 1879 Approved 1890s Approved 1900s Approved 1903 Approved 1920s Approved 1929 Approved 1930s Approved 1935 Approved 1940s Approved 1946 Approved 1949 Approved 1950 Approved 1950s Approved 1950s Approved 1950s Approved 1950s Approved 1950s Approved 1951 Approved 1952 Approved 1952

Regitine Phenoxybenzamine Serpasol Rescinnamine Diuril Harmonyl Naturetin Hydrochlorothiazide Hydrocortamate Fastin Ismel Enduron Aldactone Doburil Amiodarone Aldomet Aldoril Dyrenium Bethanidine Dyazide Locorten ( Phentolamine ) ( Phenoxybenzamine ) ( Reserpine ) ( Rescinnamine ) ( Chlorothiazide ) ( Deserpidine ) ( Bendroflumethiazide ) ( Hydrochlorothiazide ) ( Hydrocortamate ) ( Phentermine ) ( Guanethidine ) ( Methyclothiazide ) ( Spironolactone ) ( Cyclothiazide ) ( Amiodarone ) ( Methyldopa ) ( Methyldopa & Hydrochlorothiazide ) ( Triamterene ) ( Bethanidine ) ( Triamterene & Hydrochlorothiazide ) ( Flumethasone Pivalate )

PERIPHERAL VASODILATOR PERIPHERAL VASODILATOR ANTIHYPERTENSIVE ANTIHYPERTENSIVE DIURETIC ANTIHYPERTENSIVE DIURETIC DIURETIC VASOPROTECTIVE CARDIAC THERAPY ANTIHYPERTENSIVE DIURETIC DIURETIC DIURETIC CARDIAC THERAPY ANTIHYPERTENSIVE ANTIHYPERTENSIVE DIURETIC ANTIHYPERTENSIVE ANTIHYPERTENSIVE VASOPROTECTIVE Approved 1952 Approved 1953 Approved 1953 Approved 1956 Approved 1957 Approved 1957 Approved 1959 Approved 1959 Approved 1959 Approved 1959 Approved 1960 Approved 1960 Approved 1960 Approved 1960s Approved 1962 Approved 1962 Approved 1962 Approved 1964 Approved 1965 Approved 1965 Approved 1966

Lasix Atromid-S Inderol Isosorbide Dinitrate Aplin Dextrothyroxine Sermion Hyperstat Brufen Minipress Colestid Norspace Dobutamine Metoprolol Pexid Aldactazide Loniten Corgard Inderide Caverject Moduretic ( Furosemide ) ( Clofibrate ) ( Propranolol ) ( Isosorbide Dinitrate ) ( Alprenolol ) ( Dextrothyroxine ) ( Nicergoline ) ( Diazoxide ) ( Ibuprofen ) ( Prazosin ) ( Colestipol ) ( Disopyramide ) ( Dobutamine ) ( Metoprolol ) ( Perhexiline ) ( Spironolactone & Hydrochlorothiazide ) ( Minoxidil ) ( Nadolol ) ( Propranolol & Hydrochlorothiazide ) ( Alprostadil ) ( Amiloride & Hydrochlorothiazide )

DIURETIC LIPID MODIFYING AGENT BETA BLOCKING AGENT CARDIAC THERAPY BETA BLOCKING AGENT LIPID MODIFYING AGENT PERIPHERAL VASODILATOR ANTIHYPERTENSIVE CARDIAC THERAPY ANTIHYPERTENSIVE LIPID MODIFYING AGENT CARDIAC THERAPY CARDIAC THERAPY BETA BLOCKING AGENT CALC. CHAN. BLOCKER ANTIHYPERTENSIVE ANTIHYPERTENSIVE BETA BLOCKING AGENT ANTIHYPERTENSIVE CARDIAC THERAPY ANTIHYPERTENSIVE Approved 1966 Approved 1967 Approved 1967 Approved 1968 Approved 1969 Approved 1970s Approved 1972 Approved 1973 Approved 1974 Approved 1976 Approved 1977 Approved 1977 Approved 1978 Approved 1978 Approved 1978 Approved 1978 Approved 1979 Approved 1979 Approved 1979 Approved 1981 Approved 1981

Midamor Tenormin Capoten Lopid Procardia XL Nitropress Blocadren Dexamethasone Lanoxicaps Cardizem Ergikiud Fluocinolone Acetde Fluorometholone Xylocaine Visken Corzide Bumex Hydroflumethiazide Lozol Sectral Tenoretic ( Amiloride ) ( Atenolol ) ( Captopril ) ( Gemfibrozil ) ( Nifedipine ) ( Nitroprusside ) ( Timolol ) ( Dexamethasone) ( Digoxin ) ( Diltiazem ) ( Ergoloid ) ( Fluocinolone Acetonide ) ( Fluorometholone ) ( Lidocaine ) ( Pindolol ) ( Bendroflumethiazide & Nadolol ) ( Bumetanide ) ( Hydroflumethiazide ) ( Indapamide ) ( Acebutolol ) ( Atenolol & Chlorthalidone )

DIURETIC BETA BLOCKING AGENT RENIN-ANGIOTENSIN AGENT LIPID MODIFYING AGENT CALC. CHAN. BLOCKER ANTIHYPERTENSIVE BETA BLOCKING AGENT VASOPROTECTIVE CARDIAC THERAPY CALC. CHAN. BLOCKER PERIPHERAL VASODILATOR VASOPROTECTIVE VASOPROTECTIVE VASOPROTECTIVE BETA BLOCKING AGENT ANTIHYPERTENSIVE DIURETIC DIURETIC DIURETIC BETA BLOCKING AGENT ANTIHYPERTENSIVE Approved 1981 Approved 1981 Approved 1981 Approved 1981 Approved 1981 Approved 1981 Approved 1981 Approved 1982 Approved 1982 Approved 1982 Approved 1982 Approved 1982 Approved 1982 Approved 1982 Approved 1982 Approved 1983 Approved 1983 Approved 1983 Approved 1983 Approved 1984 Approved 1984

Capozide Trandate Lopressor HCT Trental Tonocard Calan Betoptic Vasotec Tambocor Mexitil Priscoline Sorbitrate Vaseretic Tenex Prelone Enkaid Fluocinonide Prinivil Mevacor Mykrox Primacor ( Captopril & Hydrochlorothiazide ) ( Labetalol ) ( Metoprolol & Hydrochlorothiazide ) ( Pentoxifylline ) ( Tocainide ) ( Verapamil ) ( Betaxolol ) ( Enalapril ) ( Flecainide ) ( Mexiletine ) ( Tolazoline ) ( Bretylium ) ( Enalapril & Hydrochlorothiazide ) ( Guanfacine ) ( Prednisolone ) ( Encainide ) ( Fluocinonide ) ( Lisinopril ) ( Lovastatin ) ( Metolazone ) ( Milrinone )

ANTIHYPERTENSIVE BETA BLOCKING AGENT ANTIHYPERTENSIVE PERIPHERAL VASODILATOR CARDIAC THERAPY CALC. CHAN. BLOCKER BETA BLOCKING AGENT RENIN-ANGIOTENSIN AGENT CARDIAC THERAPY CARDIAC THERAPY PERIPHERAL VASODILATOR CARDIAC THERAPY ANTIHYPERTENSIVE ANTIHYPERTENSIVE VASOPROTECTIVE CARDIAC THERAPY VASOPROTECTIVE RENIN-ANGIOTENSIN AGENT LIPID MODIFYING AGENT DIURETIC CARDIAC THERAPY Approved 1984 Approved 1984 Approved 1984 Approved 1984 Approved 1984 Approved 1984 Approved 1985 Approved 1985 Approved 1985 Approved 1985 Approved 1985 Approved 1986 Approved 1986 Approved 1986 Approved 1986 Approved 1987 Approved 1987 Approved 1987 Approved 1987 Approved 1987 Approved 1987

Carteolol Esmolol Cardene Nimotop Metahydrin Prinzide Rythmol Bepadin / Vascor Cardura Dynacirc Torasemide Lotensin Plendil Monopril Isosorbide Nitrate Pravachol Accupril Altace Zocor Lotensin HCT Zebeta ( Carteolol ) ( Esmolol ) ( Nicardipine ) ( Nimodipine ) ( Trichlormethiazide ) ( Lisinopril & Hydrochlorothiazide ) ( Propafenone ) ( Bepridil ) ( Doxazosin ) ( Isradipine ) ( Torasemide ) ( Benazepril ) ( Felodipine ) ( Fosinopril ) ( Isosorbide Mononitrate ) ( Pravastatin ) ( Quinapril ) ( Ramipril ) ( Simvastatin ) ( Benazepril & Hydrochlorothiazide ) ( Bisoprolol )

BETA BLOCKING AGENT BETA BLOCKING AGENT CALC. CHAN. BLOCKER CALC. CHAN. BLOCKER DIURETIC ANTIHYPERTENSIVE CARDIAC THERAPY CALC. CHAN. BLOCKER ANTIHYPERTENSIVE CALC. CHAN. BLOCKER DIURETIC RENIN-ANGIOTENSIN AGENT CALC. CHAN. BLOCKER RENIN-ANGIOTENSIN AGENT CARDIAC THERAPY LIPID MODIFYING AGENT RENIN-ANGIOTENSIN AGENT RENIN-ANGIOTENSIN AGENT LIPID MODIFYING AGENT ANTIHYPERTENSIVE BETA BLOCKING AGENT Approved 1988 Approved 1988 Approved 1988 Approved 1988 Approved 1988 Approved 1989 Approved 1989 Approved 1990 Approved 1990 Approved 1990 Approved 1990 Approved 1991 Approved 1991 Approved 1991 Approved 1991 Approved 1991 Approved 1991 Approved 1991 Approved 1991 Approved 1992 Approved 1992

Sotalol Ziac Lipidil Lescol Aceon Monopril HCT Remikiren Lotrel Coreg Corvert Cozaar Hyzaar Univasc Sular Lipitor Lexxel Proamatine Pentosan Polysulfate Tarka Mavik Arfonad ( Sotalol ) ( Bisoprolol & Hydrochlorothiazide ) ( Fenofibrate ) ( Fluvastatin ) ( Perindopril ) ( Fosinopril & Hydrochlorothiazide ) ( Remikiren ) ( Amlodipine & Benazepril ) ( Carvedilol ) ( Ibutilide ) ( Losartan ) ( Losartan & Hydrochlorothiazide ) ( Moexipril ) ( Nisoldipine ) ( Atorvastatin ) ( Enalapril & Felodipine ) ( Midodrine ) ( Pentosan Polysulfate ) ( Trandolapril & Verapamil ) ( Trandolapril ) ( Trimethaphan )

BETA BLOCKING AGENT ANTIHYPERTENSIVE LIPID MODIFYING AGENT LIPID MODIFYING AGENT RENIN-ANGIOTENSIN AGENT ANTIHYPERTENSIVE RENIN-ANGIOTENSIN AGENT ANTIHYPERTENSIVE BETA BLOCKING AGENT CARDIAC THERAPY RENIN-ANGIOTENSIN AGENT ANTIHYPERTENSIVE RENIN-ANGIOTENSIN AGENT CALC. CHAN. BLOCKER LIPID MODIFYING AGENT ANTIHYPERTENSIVE CARDIAC THERAPY VASOPROTECTIVE ANTIHYPERTENSIVE RENIN-ANGIOTENSIN AGENT ANTIHYPERTENSIVE Approved 1992 Approved 1993 Approved 1993 Approved 1993 Approved 1993 Approved 1994 Approved 1994 Approved 1995 Approved 1995 Approved 1995 Approved 1995 Approved 1995 Approved 1995 Approved 1995 Approved 1996 Approved 1996 Approved 1996 Approved 1996 Approved 1996 Approved 1996 Approved 1996

Diovan Genesa Baycol Teveten Corlopam Avalide Avapro Atacand Micardis Diovan HCT Norvasc Tykosin Nitrendipine Accuretic Atacand HCT Welchol Micardis HCT Innohep Tracleer Teveten HCT Simdax ( Valsartan ) ( Arbutamine ) ( Cerivastatin ) ( Eprosartan ) ( Fenoldopam ) ( Irbesartan & Hydrochlorothiazide ) ( Irbesartan ) ( Candesartan ) ( Telmisartan ) ( Valsartan & Hydrochlorothiazide ) ( Amlodipine ) ( Dofetilide ) ( Nitrendipine ) ( Quinapril & Hydrochlorothiazide ) ( Candesartan & Hydrochlorothiazide ) ( Colesevelam ) ( Telmisartan & Hydrochlorothiazide ) ( Tinzaparin ) ( Bosentan ) ( Eprosartan & Hydrochlorothiazide ) ( Levosimendan )

RENIN-ANGIOTENSIN AGENT CARDIAC THERAPY LIPID MODIFYING AGENT RENIN-ANGIOTENSIN AGENT CARDIAC THERAPY ANTIHYPERTENSIVE RENIN-ANGIOTENSIN AGENT RENIN-ANGIOTENSIN AGENT RENIN-ANGIOTENSIN AGENT ANTIHYPERTENSIVE CALC. CHAN. BLOCKER CARDIAC THERAPY CALC. CHAN. BLOCKER ANTIHYPERTENSIVE ANTIHYPERTENSIVE LIPID MODIFYING AGENT ANTIHYPERTENSIVE VASOPROTECTIVE ANTIHYPERTENSIVE ANTIHYPERTENSIVE CARDIAC THERAPY Approved 1996 Approved 1997 Approved 1997 Approved 1997 Approved 1997 Approved 1997 Approved 1997 Approved 1998 Approved 1998 Approved 1998 Approved 1999 Approved 1999 Approved 1999 Approved 1999 Approved 2000 Approved 2000 Approved 2000 Approved 2000 Approved 2001 Approved 2001 Approved 2001

Natrecor Advicor Plavix Inspra Zetia Lercanidipine Benicar Remodulin Benicar HCT Crestor Caduet Caduet Vytorin BiDil Ranexa Letairis AZOR Exforge Fenofibrate Tekturna HCT Cleviprex ( Nesiritide ) ( Niacin & Lovastatin ) ( Clopidogrel ) ( Eplerenone ) ( Ezetimibe ) ( Lercanidipine ) ( Olmesartan Medomoxil ) ( Treprostinil ) ( Olmesartan Medomoxil & Hydrochlorothiazide ) ( Rosuvastatin ) ( Amlodipine & Atorvastatin ) ( Amlodipine & Atorvastatin ) ( Ezetimibe & Simvastatin ) ( Hydralazine & Isosorbide Dinitrate ) ( Ranolazine ) ( Ambrisentan ) ( Amlodipine & Olmesartan Medomoxil ) ( Amlodipine & Valsartan ) ( Fenofibric Acid ) ( Aliskiren & Hydrochlorothiazide ) ( Clevidipine )

CARDIAC THERAPY LIPID MODIFYING AGENT VASOPROTECTIVE DIURETIC LIPID MODIFYING AGENT CALC. CHAN. BLOCKER RENIN-ANGIOTENSIN AGENT ANTIHYPERTENSIVE ANTIHYPERTENSIVE LIPID MODIFYING AGENT ANTIHYPERTENSIVE LIPID MODIFYING AGENT LIPID MODIFYING AGENT PERIPHERAL VASODILATOR CARDIAC THERAPY ANTIHYPERTENSIVE ANTIHYPERTENSIVE ANTIHYPERTENSIVE LIPID MODIFYING AGENT ANTIHYPERTENSIVE ANTIHYPERTENSIVE Approved 2001 Approved 2001 Approved 2002 Approved 2002 Approved 2002 Approved 2002 Approved 2002 Approved 2002 Approved 2003 Approved 2003 Approved 2004 Approved 2004 Approved 2004 Approved 2005 Approved 2006 Approved 2007 Approved 2007 Approved 2007 Approved 2007 Approved 2008 Approved 2008

Multaq Livalo Efient Adcirca Tekamlo Amturnide Pradaxa Tribenzor Edarbi Xarelto Brilinta Eliquis Vascepa Juxtapid ( Dronedarone ) ( Pitavastatin ) ( Prasugrel ) ( Tadalafil ) ( Aliskiren & Amlodipine ) ( Aliskiren, Amlopidine & Hydrochlorothiazide ) ( Dabigatran Etexilate ) ( Olmesartan Medoxomil, Amlopidine & Hydrochlorothiazide ) ( Azilsartan Medoxomil ) ( Rivaroxaban ) ( Ticagrelor ) ( Apixaban ) ( Icosapent Ethyl ) ( Lomitapide )

LIPID MODIFYING AGENT LIPID MODIFYING AGENT CARDIAC THERAPY ANTIHYPERTENSIVE ANTIHYPERTENSIVE ANTIHYPERTENSIVE VASOPROTECTIVE ANTIHYPERTENSIVE ANTIHYPERTENSIVE VASOPROTECTIVE CARDIAC THERAPY VASOPROTECTIVE LIPID MODIFYING AGENT LIPID MODIFYING AGENT Approved 2009 Approved 2009 Approved 2009 Approved 2009 Approved 2010 Approved 2010 Approved 2010 Approved 2010 Approved 2011 Approved 2011 Approved 2011 Approved 2012 Approved 2012 Approved 2012

All drugs are considered FDA approved in the U.S. following the passage of the Pure Food and Drugs Act in 1906. http://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/