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Home , Alglucosidase alfa, ATC code H01, ATC code L02, ATC code N07, Avanafil, Bezlotoxumab

Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day A ALIMENTARY TRACT AND 169,5987 A01 STOMATOLOGICAL PREPARATIONS 0,0723 A01A STOMATOLOGICAL PREPARATIONS 0,0723 A01AA Caries prophylactic agents A01AA01 (dental) 51 g A01AB Antiinfectives and for local oral treatment 0,0723 A01AB09 (O) 6958,4 g 0,2 g 0,0723 A01AB12 (O) 1802400 ml A01AB81 + (dental) 30900 pieces A01AB82 + (dental) 460 g A01AD Other agents for local oral treatment A01AD80 + (gingival) 210860 g A01AD81 Lidocaine+ (O) 34685 g A01AD82 salicylate (O) 780560 pieces A01AD83 Lidocaine+ Chamomille extract (O) 371950 g A01AD90 Lidocaine+ Paraformaldehyde (dental) 528 g A02 FOR RELATED DISORDERS 48,6099 A02A ANTACIDS 1,0401 Combinations and complexes of aluminium, calcium and A02AD 1,0401 magnesium compounds A02AD81 Aluminium hydroxide+ (O) 768200 pieces 10 pieces 0,1597 A02AD81 Aluminium hydroxide+ Magnesium hydroxide (O) 3461134 ml 50 ml 0,1439 A02AD83 Calcium carbonate+ Magnesium carbonate (O) 3543408 pieces 10 pieces 0,7366 DRUGS FOR PEPTIC ULCER AND GASTRO- A02B 47,5697 OESOPHAGEAL REFLUX DISEASE (GORD) A02BA H2-receptor antagonists 2,1028 A02BA02 (O) 300308,25 g 0,3 g 2,0808 A02BA02 Ranitidine (P) 3175,75 g 0,3 g 0,022 A02BC Proton pump inhibitors 45,4595 A02BC01 (O) 257962,34 g 0,02 g 26,8113 A02BC02 (O) 196205,1 g 0,04 g 10,1963 A02BC02 Pantoprazole (P) 461,2 g 0,04 g 0,024 A02BC03 (O) 10,5 g 0,03 g 0,0007 A02BC05 (O) 118787,76 g 0,03 g 8,2308 A02BC05 Esomeprazole (P) 2834,8 g 0,03 g 0,1964 A02BD Combinations for eradication of <0,0001 A02BD08 Bismuth subcitrate+ Tetracycline+ (O) 120 pieces 12 pieces <0,0001 Other drugs for peptic ulcer and gastro-oesophageal reflux A02BX 0,0073 disease (GORD) A02BX02 (O) 13850 g 4 g 0,0072 A02BX05 (O) 33,6 g 0,48 g 0,0001 A02BX80 (O) 3 g DRUGS FOR FUNCTIONAL GASTROINTESTINAL A03 7,9427 DISORDERS DRUGS FOR FUNCTIONAL GASTROINTESTINAL A03A 7,0126 DISORDERS A03AA Synthetic , with tertiary amino group 0,9891 A03AA04 (O) 142746 g 0,3 g 0,9891 A03AB Synthetic anticholinergics, quaternary ammonium compounds <0,0001 A03AB02 Glycopyrronium (P) 0,006 g 3 mg <0,0001 A03AD Papaverine and derivatives 4,4561 A03AD01 hydrochloride (P) 66,2 g 0,1 g 0,0014 A03AD02 (O) 210001,28 g 0,1 g 4,3653 A03AD02 Drotaverine (P) 4303 g 0,1 g 0,0894 A03AX Other drugs for functional gastrointestinal disorders 1,5674 A03AX13 Simeticone (O) 377005,5437 g 0,5 g 1,5674 A03B BELLADONNA AND DERIVATIVES, PLAIN 0,0905

1/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day A03BA Belladonna , tertiary amines 0,0782 A03BA01 (O, P) 17,34 g 0,0015 g 0,024 A03BA01 Atropine (P) 39,08 g 0,0015 g 0,0542 Belladonna alkaloids, semisynthetic, quaternary ammonium A03BB 0,0123 compounds A03BB01 (O) 51,8 g 0,06 g 0,0018 A03BB01 Hyoscine butylbromide (P) 297,9 g 0,06 g 0,0103 A03BB01 Hyoscine butylbromide (R) 6,24 g 0,06 g 0,0002 A03F PROPULSIVES 0,8396 A03FA Propulsives 0,8396 A03FA01 (O) 9698 g 0,03 g 0,672 A03FA01 Metoclopramide (P) 1874,9 g 0,03 g 0,1299 A03FA03 (O) 544,14 g 0,03 g 0,0377 A04 ANTIEMETICS AND ANTINAUSEANTS 0,1243 A04A ANTIEMETICS AND ANTINAUSEANTS 0,1243 A04AA (5-HT3) antagonists 0,1107 A04AA01 Ondansetron (P) 34,76 g 0,016 g 0,0045 A04AA02 Granisetron (O) 59,76 g 0,002 g 0,0621 A04AA02 Granisetron (P) 63,61 g 0,003 g 0,0441 A04AD Other antiemetics 0,0136 A04AD01 (TD) 10 pieces 1 pieces <0,0001 A04AD12 Aprepitant (O) 332,025 g 0,095 g 0,0073 A04AD81 Fosaprepitant (P) 288,45 g 0,095 g 0,0063 A05 AND 2,2636 A05A BILE THERAPY 0,4938 A05AA preparations 0,4938 A05AA02 Ursodeoxycholic acid (O) 178150 g 0,75 g 0,4938 A05B LIVER THERAPY, LIPOTROPICS 1,7698 A05BA Liver therapy 1,7698 A05BA03 Silymarin (O) 2644490 pieces A05BA80 Essential phospholipids (O) 2554230 pieces 3 pieces 1,7698 A05BA80 Essential phospholipids (P) 1945 pieces A06 DRUGS FOR 15,5975 A06A DRUGS FOR CONSTIPATION 15,5975 A06AB Contact 7,4335 A06AB02 Bisacodyl (O) 14969,2 g 0,01 g 3,1116 A06AB02 Bisacodyl (R) 999 g 0,01 g 0,2077 A06AB06 Senna (O) 8440 pieces 1 pieces 0,0175 A06AB08 Sodium picosulfate (O) 9852,8073 g 0,005 g 4,0962 A06AB80 Sodium picosulfate+ Magnesium oxide+ (O) 460 pieces 2 pieces 0,0005 A06AC Bulk-forming laxatives <0,0001 A06AC01 Hemicellulose of Ispaghula (O) 0,585 g 7 g <0,0001 A06AD Osmotically acting laxatives 7,3069 A06AD11 Lactulose (O) 22314644,9 g 6,7 g 6,9232 A06AD15 Macrogol (O) 1846000 g 10 g 0,3837 Macrogol+ Sodium citrate+ Citric acid+ + A06AD80 14400 ml (O) Sodium sulphate, anhydrous+ Potassium chloride+ Sodium A06AD81 58596 pieces chloride+ Macrogol+ Sodium hydrogen carbonate (O)

Macrogol+ Sodium sulphate, anhydrous+ Sodium chloride+ A06AD83 280 pieces Potassium chloride+ Ascorbic acid+ Sodium ascorbate (O) Sodium sulphate, anhydrous+ A06AD85 796224 ml heptahydrate+ Potassium sulphate (O) A06AG 0,8499 A06AG11 Laurilsulfate, incl. combinations+ Sorbitol+ Sodium citrate (R) 408872 pieces 1 pieces 0,8499 A06AH Peripheral receptor antagonists 0,0071

2/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day A06AH03 Naloxegol (O) 85,5 g 25 mg 0,0071 ANTIDIARRHEALS, INTESTINAL A07 4,0713 ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS A07A INTESTINAL ANTIINFECTIVES 0,0003 A07AA 0,0003 A07AA02 (O) 20000000 U 1500000 U <0,0001 A07AA06 Paromomycin (O) 42 g A07AA11 (O) 55,2 g 0,6 g 0,0002 A07AA12 Fidaxomicin (O) 8 g 0,4 g <0,0001 A07B INTESTINAL ADSORBENTS 0,4412 A07BC Other intestinal adsorbents 0,4412 A07BC05 Diosmectidum (O) 1910070 g 9 g 0,4412 A07C ELECTROLYTES WITH CARBOHYDRATES A07CA Oral rehydration formulations Sodium chloride+ Potassium chloride+ Sodium citrate+ A07CA80 68200 pieces Glucose (O) A07D 0,9968 A07DA Antipropulsives 0,9968 A07DA03 (O) 4795,472 g 0,01 g 0,9968 A07DA06 (O) 16,8 g A07E INTESTINAL ANTIINFLAMMATORY AGENTS 2,0161 A07EA acting locally 0,0023 A07EA06 (O) 9,99 g 0,009 g 0,0023 A07EA06 Budesonide (R) 0,9352 g A07EC Aminosalicylic acid and similar agents 2,0137 A07EC01 (O) 796650 g 2 g 0,828 A07EC02 (O) 788185 g 1,5 g 1,0923 A07EC02 Mesalazine (R) 67458 g 1,5 g 0,0935 A07F ANTIDIARRHEAL MICROORGANISMS 0,617 A07FA Antidiarrheal microorganisms 0,617 A07FA02 Saccharomyces boulardii (O) 296797,5 g 1 g 0,617 A07X OTHER ANTIDIARRHEALS A07XA Other antidiarrheals A07XA04 (O) 3311 g A08 ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS 0,0522 A08A ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS 0,0522 A08AA Centrally acting antiobesity products 0,0363 A08AA62 Bupropione+ (O) 69776 pieces 4 pieces 0,0363 A08AB Peripherally acting antiobesity products 0,016 A08AB01 Orlistat (O) 2766,96 g 0,36 g 0,016 A09 DIGESTIVES, INCL. 1,4828 A09A DIGESTIVES, INCL. ENZYMES 1,4828 A09AA preparations 1,4827 A09AA02 Lipase+ Amylase+ Protease (O) 2853211 pieces 4 pieces 1,4827 A09AC Enzyme and acid preparations, combinations 0,0001 A09AC80 + Betaine (O) 150 pieces 3 pieces 0,0001 A10 DRUGS USED IN DIABETES 62,3756 A10A INSULINS AND ANALOGUES 16,3017 A10AB Insulins and analogues for injection, fast-acting 6,1563 A10AB01 Insulin (human) (P) 874500 U 40 U 0,0454 A10AB04 Insulin lispro (P) 25911000 U 40 U 1,3465 A10AB05 Insulin aspart (P) 77940000 U 40 U 4,0503 A10AB06 Insulin glulisine (P) 13738500 U 40 U 0,714 A10AC Insulins and analogues for injection, intermediate-acting 0,1188 A10AC01 Insulin (human) (P) 2286000 U 40 U 0,1188 Insulins and analogues for injection, intermediate- or long- A10AD 1,2917 acting combined with fast-acting

3/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day A10AD04 Insulin lispro (P) 8655000 U 40 U 0,4498 A10AD05 Insulin aspart (P) 16201500 U 40 U 0,842 A10AE Insulins and analogues for injection, long-acting 8,7349 A10AE04 Insulin glargine (P) 102192750 U 40 U 5,3107 A10AE05 Insulin detemir (P) 65892000 U 40 U 3,4242 A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS 46,0739 A10BA 20,0821 A10BA02 Metformin (O) 19321782 g 2 g 20,0821 A10BB Sulfonylureas 14,4784 A10BB07 (O) 1154,55 g 0,01 g 0,24 A10BB09 (O) 232998,6 g 0,06 g 8,0722 A10BB12 (O) 5932,68 g 0,002 g 6,1661 A10BD Combinations of oral blood glucose lowering drugs 5,0782 A10BD07 Metformin+ Sitagliptin (O) 2025856 pieces 2 pieces 2,1056 A10BD08 Metformin+ Vildagliptin (O) 949140 pieces 2 pieces 0,9865 A10BD10 Metformin+ Saxagliptin (O) 321240 pieces 2 pieces 0,3339 A10BD11 Metformin+ Linagliptin (O) 769740 pieces 2 pieces 0,8 A10BD15 Metformin+ Dapagliflozin (O) 255024 pieces 2 pieces 0,2651 A10BD19 Linagliptin+ Empagliflozin (O) 17910 pieces 1 pieces 0,0372 A10BD20 Metformin+ Empagliflozin (O) 495780 pieces 2 pieces 0,5153 A10BD21 Saxagliptin+ Dapagliflozin (O) 16688 pieces 1 pieces 0,0347 A10BF Alpha glucosidase inhibitors 0,0005 A10BF01 Acarbose (O) 78,75 g 0,3 g 0,0005 A10BG Thiazolidinediones 0,1108 A10BG03 Pioglitazone (O) 1599,78 g 0,03 g 0,1108 A10BH Dipeptyl peptidase 4 (DPP-4) inhibitors 3,4946 A10BH01 Sitagliptin (O) 71697,5 g 0,1 g 1,4904 A10BH02 Vildagliptin (O) 7461 g 0,1 g 0,1551 A10BH03 Saxagliptin (O) 495,9 g 5 mg 0,2062 A10BH05 Linagliptin (O) 3951,9 g 5 mg 1,643 A10BJ Glucagon-like peptide-1 (GLP-1) analogues 1,5296 A10BJ01 Exenatide (P) 0,0612 g 15 mcg 0,0085 A10BJ01 Exenatide (P) 11,648 g 0,286 mg 0,0847 A10BJ02 Liraglutide (P) 750,708 g 1,2 mg 1,3004 A10BJ03 Lixisenatide (P) 1,3094 g 20 mcg 0,1361 A10BK Sodium-glucose co-transporter 2 (SGLT2) inhibitors 1,2996 A10BK01 Dapagliflozin (O) 2785,65 g 10 mg 0,5791 A10BK03 empagliflozin (O) 6065,7 g 17,5 mg 0,7205 A11 VITAMINS 16,0882 A11A MULTIVITAMINS, COMBINATIONS 2,1198 A11AA Multivitamins with 2,1198 A11AA03 Multivitamins+ elements (O) 1019790 pieces 1 pieces 2,1198 A11C VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO 0,8464 A11CA Vitamin A, plain <0,0001 A11CA01 Retinol (P) 600000 U 50000 U <0,0001 A11CC Vitamin D and analogues 0,8464 A11CC01 Ergocalciferol (O) 119436800 U 400 U 0,6207 A11CC03 Alfacalcidol (O) 0,001 g 0,001 mg 0,0022 A11CC04 Calcitriol (O) 0,0895 g 0,001 mg 0,1861 A11CC05 Colecalciferol (O) 7200000 U 400 U 0,0374 A11CC05 Colecalciferol (P) 5500000 U VITAMIN B1, PLAIN AND IN COMBINATION WITH VITAMIN A11D 2,0678 B6 AND B12 A11DA Vitamin B1, plain 0,3463 A11DA01 (P) 8329,5 g 0,05 g 0,3463 A11DA03 (O) 1820660 pieces A11DB Vitamin B1 in combination with vitamin B6 and/or vitamin B12 1,7215

4/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day A11DB80 Thiamine+ Pyridoxine (P) 4055 pieces 1 pieces 0,0084 A11DB81 Benfotiamine+ Pyridoxine (O) 168930 pieces 3 pieces 0,1171 A11DB84 Thiamine+ Pyridoxine+ Cyanocobalamin (O) 673950 pieces 1 pieces 1,4009 A11DB85 Thiamine+ Pyridoxine+ Cyanocobalamin+ Lidocaine (P) 93845 pieces 1 pieces 0,1951 A11E VITAMIN B-COMPLEX, INCL. COMBINATIONS 0,7184 A11EA Vitamin B-complex, plain 0,7184 Thiamine+ Nicotinamide+ Riboflavin+ Calcium pantothenate+ A11EA80 345600 pieces 1 pieces 0,7184 Pyridoxine (O) A11G ASCORBIC ACID (), INCL. COMBINATIONS 1,8269 A11GA Ascorbic acid (vitamin C), plain 1,8269 A11GA01 Ascorbic acid (O) 166580 g 0,2 g 1,7313 A11GA01 Ascorbic acid (P) 9195 g 0,2 g 0,0956 A11H OTHER PLAIN VITAMIN PREPARATIONS 0,0396 A11HA Other plain vitamin preparations 0,0396 A11HA02 Pyridoxine (O) 150 g 0,16 g 0,0019 A11HA02 Pyridoxine (P) 2609 g 0,16 g 0,0339 A11HA03 Tocopherol (O) 40 g 0,2 g 0,0004 A11HA03 Tocopherol (P) 15 g 0,2 g 0,0002 A11HA08 Tocofersolan (O) 306 g 0,2 g 0,0032 A11J OTHER VITAMIN PRODUCTS, COMBINATIONS 8,4693 A11JA Combinations of vitamins A11JA80 Combinations of vitamins (O) 1000 ml A11JB Vitamins with minerals 8,4693 A11JB81 Pyridoxine+ Magnesium (O) 12762650 pieces 4 pieces 6,6324 Thiamine+ Riboflavin+ Pyridoxine+ Cyanocobalamin+ A11JB82 Ascorbic acid+ Biotin+ Nicotinamide+ Calcium pantothenate+ 883650 pieces 1 pieces 1,8368 Calcium+ Magnesium+ Folic acid+ Zinc (O) A12 MINERAL SUPPLEMENTS 10,5411 A12A CALCIUM 6,8662 A12AA Calcium 0,7265 A12AA03 (P) 19760 g 3 g 0,0137 A12AA04 Calcium carbonate (O) 1028750 g 3 g 0,7128 A12AX Calcium, combinations with vitamin D and/or other drugs 6,1396 A12AX80 Calcium+ Colecalciferol (O) 1182270 pieces 1 pieces 2,4576 A12AX80 Calcium+ Colecalciferol (O) 3542660 pieces 2 pieces 3,6821 A12B POTASSIUM 3,1218 A12BA Potassium 3,1218 A12BA01 Potassium chloride (O) 271560 g 3 g 0,1882 A12BA80 Potassium chloride+ Potassium hydrogen carbonate (O) 1800 pieces A12BA81 Potassium aspartate+ (O) 4170500 pieces 3 pieces 2,8897 A12BA81 Potassium aspartate+ Magnesium aspartate (P) 21125 pieces 1 pieces 0,0439 A12C OTHER MINERAL SUPPLEMENTS 0,5531 A12CC Magnesium 0,5531 A12CC04 (O) 532170,344 g 2 g 0,5531 A12CX Other mineral products A12CX83 (O) 11000 pieces A14 ANABOLIC AGENTS FOR SYSTEMIC USE 0,0024 A14A ANABOLIC STEROIDS 0,0024 A14AB Estren derivatives 0,0024 A14AB01 (P) 2,3 g 0,002 g 0,0024 A14B OTHER ANABOLIC AGENTS A14BX Other anabolic agents A14BX80 Riboxine (O) 180 g OTHER ALIMENTARY TRACT AND METABOLISM A16 0,3748 PRODUCTS

5/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day OTHER ALIMENTARY TRACT AND METABOLISM A16A 0,3748 PRODUCTS A16AA Amino and derivatives 0,0022 A16AA01 Levocarnitine (O) 2070 g 2 g 0,0022 A16AA02 Ademetionine (O) 290 g A16AA81 Glycine (O) 1365 g A16AB Enzymes 0,0065 A16AB02 (P) 154800 U 300 U 0,0011 A16AB03 Agalsidase alfa (P) 1,281 g 0,001 g 0,0027 A16AB04 Agalsidase beta (P) 3,71 g 0,005 g 0,0015 A16AB07 Alglucosidase alfa (P) 55,1 g 0,1 g 0,0011 A16AB09 (P) 1,152 g A16AB10 (P) 14400 U 300 U 0,0001 A16AX Various alimentary tract and metabolism products 0,3662 A16AX01 Thioctic acid (O) 102798 g 0,6 g 0,3561 A16AX01 Thioctic acid (P) 492 g 0,6 g 0,0017 A16AX03 (O) 2500 g 20 g 0,0003 A16AX05 Zinc (O) 581,25 g 0,15 g 0,0081 A16AX07 Sapropterin (O) 324 g A16AX80 Creatine (O) 450 g B BLOOD AND BLOOD FORMING ORGANS 106,8893 B01 AGENTS 85,1776 B01A ANTITHROMBOTIC AGENTS 85,1776 B01AA antagonists 6,3662 B01AA03 (O) 22969,3 g 0,0075 g 6,3662 B01AB group 2,9583 B01AB01 Heparin sodium (P) 529175000 U 10000 U 0,11 B01AB04 (P) 105550000 U 2500 U 0,0878 B01AB05 (P) 2207632000 U 2000 U 2,2945 B01AB06 (P) 31084000 U 2850 U 0,0227 B01AB12 (P) 533200000 U 2500 U 0,4433 B01AC Platelet aggregation inhibitors, excl. heparin 65,4629 B01AC04 (O) 159521,55 g 0,075 g 4,4213 B01AC06 Acetylsalicylic acid (O) 6430164 pieces 1 pieces 13,3664 B01AC07 (O) 45 g 0,4 g 0,0002 B01AC09 Epoprostenol (P) 0,011 g B01AC11 (I) 0,0403 g 0,15 mg 0,0006 B01AC11 Iloprost (P) 0,0026 g 50 mcg 0,0001 B01AC16 (P) 61,665 g 0,2 g 0,0006 B01AC17 (P) 0,025 g 10 mg <0,0001 B01AC24 Ticagrelor (O) 80381,28 g 0,18 g 0,9283 B01AC80 Acetylsalicylic acid + Magnesium oxide (O) 22487800 pieces 1 pieces 46,7454 B01AD Enzymes 0,002 B01AD01 (P) 15000000 U 1500000 U <0,0001 B01AD02 Alteplase (P) 78,1 g 0,1 g 0,0016 B01AD11 (P) 6,5 g 0,04 g 0,0003 B01AE Direct inhibitors 1,7372 B01AE07 etexilate (O) 250715,5 g 0,3 g 1,7372 B01AF Direct factor Xa inhibitors 8,642 B01AF01 (O) 58890,73 g 0,02 g 6,1208 B01AF02 (O) 12128,7 g 10 mg 2,5212 B01AX Other antithrombotic agents 0,0091 B01AX01 Defibrotide (P) 42 g 1,75 g <0,0001 B01AX05 Fondaparinux sodium (P) 10,9 g 0,0025 g 0,0091 B02 ANTIHEMORRHAGICS 0,1535 B02A ANTIFIBRINOLYTICS 0,1371 B02AA Amino acids 0,1371 B02AA01 Aminocaproic acid (P) 25625 g 16 g 0,0033 B02AA02 Tranexamic acid (O) 98570 g 2 g 0,1024

6/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day B02AA02 Tranexamic acid (P) 30135 g 2 g 0,0313 B02B VITAMIN K AND OTHER HEMOSTATICS 0,0164 B02BA Vitamin K 0,0066 B02BA01 Phytomenadione (P) 38,54 g 0,02 g 0,004 B02BA02 Menadione (P) 2,5 g 0,002 g 0,0026 B02BB <0,0001 B02BB01 Fibrinogen (P) 10 g 5 g <0,0001 B02BC Local hemostatics B02BC81 Fibrinogen human+ Human thrombin (epil) 522 pieces B02BD Blood coagulation factors B02BD01 Human prothrombin complex (P) 215000 U B02BD02 Human coagulation factor VIII (P) 2368500 U B02BD03 Factor VIII inhibitor bypassing activity (P) 2132000 U B02BD04 Human coagulation factor IX (P) 501600 U B02BD05 Human coagulation factor VII (P) 193200 U Von Willebrand factor, human+ Human coagulation factor VIII B02BD06 2051800 U (P) B02BD08 Eptacog alfa (activated) (P) 7050000 U B02BD81 Simoctocog alfa (P) 1910750 U B02BX Other systemic hemostatics 0,0098 B02BX01 (P) 1887,5 g B02BX04 Romiplostim (P) 0,008 g 30 mcg 0,0006 B02BX05 Eltrombopag (O) 221,9 g 50 mg 0,0092 B03 ANTIANEMIC PREPARATIONS 21,558 B03A PREPARATIONS 3,714 B03AA Iron bivalent, oral preparations 2,515 B03AA07 Ferrous sulphate (O) 241980 g 0,2 g 2,515 B03AB Iron trivalent, oral preparations B03AB80 Iron (III) hydroxide polymaltose complex (O) 74385,5 g B03AC Iron, parenteral preparations 0,0537 B03AC01 Dextriferron (P) 196 g 0,1 g 0,0041 B03AC02 Iron (III) hydroxide sucrose complex (P) 1247,5 g 0,1 g 0,0259 B03AC06 Iron (III)-hydroxide dextran complex (P) 971,5 g 0,1 g 0,0202 B03AC80 Iron (III) isomaltoside 1000 complex (P) 169,5 g 0,1 g 0,0035 B03AD Iron in combination with folic acid 1,1453 B03AD02 Ferrous fumarate+ Folic acid (O) 550960 pieces 1 pieces 1,1453 B03AE Iron in other combinations Ferrous gluconate+ Manganese gluconate+ gluconate B03AE81 1729200 ml (O) B03B VITAMIN B12 AND FOLIC ACID 17,1378 B03BA Vitamin B12 (cyanocobalamin and analogues) 6,5422 B03BA01 Cyanocobalamin (O) 10,3 g 1 mg 0,0214 B03BA01 Cyanocobalamin (P) 62,505 g 0,02 mg 6,4965 B03BA03 (P) 0,234 g 0,02 mg 0,0243 B03BB Folic acid and derivatives 10,5957 B03BB01 Folic acid (O) 2038,9 g 0,4 mg 10,5957 B03X OTHER ANTIANEMIC PREPARATIONS 0,7061 B03XA Other antianemic preparations 0,7061 B03XA02 Darbepoetin alfa (P) 1,0334 g 0,0045 mg 0,4774 B03XA03 Methoxy -epoetin beta (P) 0,1924 g 4 mcg 0,1 B03XA80 Epoetin beta (P) 61932000 U 1000 U 0,1287 B05 BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS B05A BLOOD AND RELATED PRODUCTS B05AA Blood substitutes and plasma fractions B05AA01 Albumin (P) 577180 g B05AA05 Dextran (P) 1200 ml B05AA06 Gelatin agents (P) 11894500 ml B05AA80 Hydroxyethyl starch+ Sodium chloride (P) 33000 ml B05AA81 Dextran+ Sodium chloride (P) 63000 ml

7/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day Gelatine+ Sodium chloride+ Potassium chloride+ Magnesium B05AA83 2820000 ml chloride+ Sodium lactate (P) Hydroxyethyl starch+ Sodium chloride+ Potassium chloride+ B05AA84 dihydrate+ + Sodium 60000 ml acetate trihydrate+ Malic acid (P) B05AA86 human plasma (P) 116000 ml B05B I.V. SOLUTIONS B05BA Solutions for parenteral nutrition B05BA01 Amino acids (P) 1150500 ml B05BA02 Fat emulsions (P) 226000 ml B05BA03 Carbohydrates (P) 5400 g B05BA03 Carbohydrates (P) 75198930 ml B05BA10 Combinations (P) 14721036 ml B05BA83 Amino acids+ Electrolytes+ Glucose (P) 60000 ml B05BB Solutions affecting the electrolyte balance B05BB01 Electrolytes (P) 145620500 ml B05BB03 Trometamol (P) 1000 ml B05BC Solutions producing osmotic diuresis B05BC01 Mannitol (P) 960000 ml B05C IRRIGATING SOLUTIONS B05CX Other irrigating solutions B05CX10 Combinations (NA) 170000 ml B05D PERITONEAL DIALYTICS B05DA Isotonic solutions B05DA80 Isotonic solutions (P) 7710000 ml B05DB Hypertonic solutions B05DB80 hypertonic solutions (P) 131292000 ml Amino acids+ Sodium chloride+ Calcium chloride dihydrate+ B05DB81 1740000 ml Magnesium chloride hexahydrate+ Sodium lactate (P) B05Z HEMODIALYTICS AND HEMOFILTRATES B05ZB Hemofiltrates Sodium chloride+ Potassium chloride+ Calcium chloride B05ZB80 dihydrate+ Magnesium chloride+ Glucose+ Sodium hydrogen 24110000 ml carbonate (P)

Sodium chloride+ Calcium chloride dihydrate+ Magnesium B05ZB81 100000 ml chloride+ Glucose+ Sodium hydrogen carbonate (P)

Calcium chloride dihydrate+ Magnesium chloride B05ZB82 hexahydrate+ Sodium chloride+ Sodium hydrogen carbonate+ 12770000 ml Potassium chloride+ dihydrate (P)

Calcium chloride dihydrate+ Magnesium chloride B05ZB84 hexahydrate+ + Sodium hydrogen carbonate+ 1570000 ml Sodium chloride (P) B05ZB85 Sodium citrate+ Sodium chloride (P) 30000 ml Magnesium chloride hexahydrate+ Sodium chloride+ B05ZB86 Potassium chloride+ Disodium phosphate dihydrate+ Sodium 200000 ml hydrogen carbonate (P) B05X I.V. SOLUTION ADDITIVES B05XA Electrolyte solutions B05XA01 Potassium chloride (P) 3468000 ml B05XA02 Sodium hydrogen carbonate (P) 1559000 ml B05XA03 Sodium chloride (P) 513738950 ml B05XA05 Magnesium sulphate (P) 63525 g B05XA05 Magnesium sulphate (P) 199400 ml B05XA07 Calcium chloride (P) 234800 ml B05XA14 Sodium glycerophosphate, hydrated (P) 90200 ml B05XA80 Electrolytes (P) 95400 ml

8/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day B05XB Amino acids B05XB02 Alanyl (P) 158100 ml B05XC Vitamins B05XC80 Vitamins (P) 190100 ml B06 OTHER HEMATOLOGICAL AGENTS 0,0002 B06A OTHER HEMATOLOGICAL AGENTS 0,0002 B06AA Enzymes B06AA03 Hyaluronidase (P) 45000 U B06AB Other hem products B06AB81 Hemin (P) 40 ml B06AC Drugs usedin hereditary angioedema 0,0002 B06AC01 C1-inhibitor (P) 13000 U 1400 U <0,0001 B06AC02 Icatibant (P) 1,14 g 0,03 g 0,0001 B06AC04 Conestat alfa (P) 157500 U 3500 U 0,0001 C CARDIOVASCULAR SYSTEM 418,1719 C01 CARDIAC THERAPY 26,9531 C01A CARDIAC GLYCOSIDES 3,333 C01AA Digitalis glycosides 3,333 C01AA05 Digoxin (O) 397,2237 g 0,25 mg 3,3028 C01AA05 Digoxin (P) 3,4725 g 0,25 mg 0,0289 C01AA06 Lanatoside C (O) 0,6375 g 0,001 g 0,0013 C01B ANTIARRHYTHMICS, CLASS I AND III 6,4401 C01BA Antiarrhythmics, class Ia C01BA13 Hydroquinidine (O) 252 g C01BB Antiarrhythmics, class Ib 0,0539 C01BB02 (O) 100 g 0,8 g 0,0003 C01BB80 Aethacizin (O) 5157,5 g 0,2 g 0,0536 C01BC Antiarrhythmics, class Ic 3,9256 C01BC03 Propafenone (O) 549975 g 0,3 g 3,8108 C01BC03 Propafenone (P) 783,65 g 0,3 g 0,0054 C01BC04 (O) 10480 g 0,2 g 0,1089 C01BC04 Flecainide (P) 43,5 g 0,2 g 0,0005 C01BD Antiarrhythmics, class III 2,4606 C01BD01 (O) 228996 g 0,2 g 2,3801 C01BD01 Amiodarone (P) 6156,75 g 0,2 g 0,064 C01BD07 Dronedarone (O) 6384 g 0,8 g 0,0166 C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES 0,9971 C01CA and agents 0,9963 C01CA01 Etilefrine (O) 3,325 g 0,05 g 0,0001 C01CA02 Isoprenaline (P) 0,721 g 0,09 g <0,0001 C01CA03 Norepinephrine (P) 292,438 g 0,006 g 0,1013 C01CA04 (P) 1393 g 0,5 g 0,0058 C01CA06 Phenylephrine (P) 263,7 g 0,004 g 0,137 C01CA07 Dobutamine (P) 1111,25 g 0,5 g 0,0046 C01CA17 Midodrine (O) 6,75 g 0,03 g 0,0005 C01CA24 Epinephrine (P) 170,949 g 0,5 mg 0,7107 C01CA26 Ephedrine (P) 871,5 g 0,05 g 0,0362 C01CE inhibitors 0,0005 C01CE02 (P) 11,1 g 0,05 g 0,0005 C01CX Other cardiac stimulants 0,0003 C01CX08 Levosimendan (P) 1,4875 g 11 mg 0,0003 C01CX80 (I) 1256640 ml C01D VASODILATORS USED IN CARDIAC DISEASES 7,2539 C01DA Organic nitrates 7,2523 C01DA02 Glyceryl trinitrate (P) 268,1 g C01DA02 Glyceryl trinitrate (SL) 575,728 g 0,0025 g 0,4787 C01DA05 Pentaerithrityl tetranitrate (O) 1 g 0,12 g <0,0001 C01DA08 Isosorbide dinitrate (O) 12069,25 g 0,06 g 0,4181

9/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day C01DA08 Isosorbide dinitrate (SL) 16,725 g 0,02 g 0,0017 C01DA14 Isosorbide mononitrate (O) 122262 g 0,04 g 6,3536 C01DX Other vasodilatators used in cardiac diseases 0,0017 C01DX80 Meldonium (O) 600 g 0,75 g 0,0017 C01E OTHER CARDIAC PREPARATIONS 8,929 C01EA 0,0003 C01EA01 Alprostadil (P) 0,0752 g 0,5 mg 0,0003 C01EB Other cardiac preparations 8,9287 C01EB10 Adenosine (P) 91,38 g 0,015 g 0,0127 C01EB15 Trimetazidine (O) 164556 g 0,04 g 8,5516 C01EB16 (P) 0,84 g 0,03 g 0,0001 C01EB17 Ivabradine (O) 1637,58 g 0,01 g 0,3404 C01EB18 (O) 17040 g 1,5 g 0,0236 C01EB21 Regadenoson (P) 0,068 g 0,4 mg 0,0004 C02 ANTIHYPERTENSIVES 3,8873 C02A ANTIADRENERGIC AGENTS, CENTRALLY ACTING 2,4245 C02AC Imidazoline receptor agonists 2,4245 C02AC01 (O) 4,935 g 0,45 mg 0,0228 C02AC01 Clonidine (P) 4,9725 g 0,45 mg 0,023 C02AC05 Moxonidine (O) 343,3072 g 0,3 mg 2,3788 C02C ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING 1,44 C02CA Alpha-adrenoreceptor antagonists 1,44 C02CA04 Doxazosin (O) 2770,9 g 0,004 g 1,44 C02D ARTERIOLAR SMOOTH MUSCLE, AGENTS ACTING ON 0,0009 C02DD Nitroferricyanide derivatives 0,0009 C02DD01 Sodium nitroprusside (P) 22 g 0,05 g 0,0009 C02K OTHER ANTIHYPERTENSIVES 0,0219 C02KX Antihypertensives for pulmonary arterial hypertension 0,0219 C02KX01 Bosentan (O) 1498 g 0,25 g 0,0125 C02KX02 Ambrisentan (O) 18,15 g 7,5 mg 0,005 C02KX05 Riociguat (O) 9,597 g 4,5 mg 0,0044 C03 DIURETICS 24,6638 C03A LOW-CEILING DIURETICS, 1,9226 C03AA Thiazides, plain 1,9226 C03AA03 Hydrochlorothiazide (O) 23123 g 0,025 g 1,9226 C03B LOW-CEILING DIURETICS, EXCL. THIAZIDES 2,4585 C03BA Sulfonamides, plain 2,4585 C03BA08 Metolazone (O) 0,75 g 5 mg 0,0003 C03BA11 Indapamide (O) 2956,395 g 2,5 mg 2,4582 C03C HIGH-CEILING DIURETICS 17,2919 C03CA Sulfonamides, plain 17,2919 C03CA01 (O) 81680,4 g 0,04 g 4,2447 C03CA01 Furosemide (P) 4459,1 g 0,04 g 0,2317 C03CA04 Torasemide (O) 91904,55 g 0,015 g 12,7361 C03CA04 Torasemide (P) 572,3 g 0,015 g 0,0793 C03D POTASSIUM-SPARING AGENTS 2,9765 C03DA Aldosterone antagonists 2,9765 C03DA01 (O) 107063,75 g 0,075 g 2,9674 C03DA04 Eplerenone (O) 218,25 g 0,05 g 0,0091 DIURETICS AND POTASSIUM-SPARING AGENTS IN C03E 0,0143 COMBINATION C03EA Low-ceiling diuretics and potassium-sparing agents 0,0142 C03EA81 Hydrochlorothiazide+ (O) 6840 pieces 1 pieces 0,0142 C03EB High-ceiling diuretics and potassium-sparing agents 0,0001 C03EB81 Furosemide+ Spironolactone (O) 100 pieces 3 pieces 0,0001 C04 PERIPHERAL VASODILATORS 2,7935 C04A PERIPHERAL VASODILATORS 2,7935

10/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day C04AC Nicotinic acid and derivatives 0,0003 C04AC01 Nicotinic acid (P) 33 g 0,2 g 0,0003 C04AD Purine derivatives 2,0377 C04AD02 Xantinol nicotinate (O) 378 g 0,9 g 0,0009 C04AD03 (O) 977048 g 1 g 2,031 C04AD03 Pentoxifylline (P) 845,5 g 0,3 g 0,0059 C04AX Other peripheral vasodilators 0,7554 C04AX21 Naftidrofuryl (O) 218040 g 0,6 g 0,7554 C05 AGENTS FOR TREATMENT OF AND ANAL C05A FISSURES FOR TOPICAL USE C05AA Corticosteroids C05AA82 + (R) 39828 pieces C05AA84 + Lidocaine (R) 162075 g C05AA84 Fluocortolone+ Lidocaine (R) 283990 pieces C05AE Muscle relaxants C05AE01 Glyceryl trinitrate (R) 60 g Other agents for treatment of hemorrhoids and anal fissures C05AX for topical use C05AX81 Xeroformium+ Zinc sulphate+ Extract of Belladonna (R) 5950 pieces C05AX83 Yeast cell extract+ Shark liver oil (R) 286332 pieces C05AX85 Hippopheae oleum (R) 210 pieces C05B ANTIVARICOSE THERAPY C05BA or for topical use C05BA01 Chondroitin polysulfate (C) 218360 g C05BA03 Heparin sodium (C) 7418900 g C05BB Sclerosing agents for local injection C05BB02 Lauromacrogol 400 (P) 103,575 g C05C CAPILLARY STABILIZING AGENTS C05CA Bioflavonoids C05CA01 Rutoside (C) 2960 g C05CA01 Rutoside (O) 288750 pieces C05CA03 (O) 2010 g C05CA04 (C) 3519840 g C05CA04 Troxerutin (O) 235680 g C05CA53 Diosmin+ Hesperidine (O) 3330 pieces C05CX Other capillary stabilizing agents C05CX80 Vigne rouge extract (O) 18 g C05CX81 Aescin (O) 95080 pieces C07 BETA BLOCKING AGENTS 51,4672 C07A BETA BLOCKING AGENTS 51,4665 C07AA Beta blocking agents, non-selective 1,8005 C07AA05 (O) 40950 g 0,16 g 0,532 C07AA07 (O) 97637,6 g 0,16 g 1,2685 C07AB Beta blocking agents, selective 48,992 C07AB02 Metoprolol (O) 1789124,8 g 0,15 g 24,7937 C07AB02 Metoprolol (P) 91,425 g 0,15 g 0,0013 C07AB03 Atenolol (O) 25395,75 g 0,075 g 0,7039 C07AB07 Bisoprolol (O) 10648,125 g 0,01 g 2,2134 C07AB12 Nebivolol (O) 51185,33 g 0,005 g 21,2798 C07AG Alpha and beta blocking agents 0,6739 C07AG01 Labetalol (O) 23055 g 0,6 g 0,0799 C07AG01 Labetalol (P) 901 g 0,6 g 0,0031 C07AG02 Carvedilol (O) 10660,3125 g 0,0375 g 0,5909 C07B BETA BLOCKING AGENTS AND THIAZIDES 0,0007 C07BB Beta blocking agents, selective, and thiazides 0,0007 C07BB07 Bisoprolol+ Hydrochlorothiazide (O) 360 pieces 1 pieces 0,0007 C08 CALCIUM CHANNEL BLOCKERS 51,9466

11/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY C08C 50,068 VASCULAR EFFECTS C08CA Dihydropyridine derivatives 50,068 C08CA01 (O) 67132,8 g 0,005 g 27,9098 C08CA02 (O) 8492,925 g 0,005 g 3,5308 C08CA05 (O) 20616,08 g 0,03 g 1,4285 C08CA06 (O) 354 g 0,3 g 0,0025 C08CA06 Nimodipine (P) 2,7 g 0,05 g 0,0001 C08CA08 (O) 50294,52 g 0,02 g 5,2274 C08CA09 (O) 7989,464 g 0,004 g 4,1519 C08CA13 (O) 37605,6 g 0,01 g 7,8171 SELECTIVE CALCIUM CHANNEL BLOCKERS WITH DIRECT C08D 1,8785 CARDIAC EFFECTS C08DA Phenylalkylamine derivatives 1,7945 C08DA01 (O) 207172 g 0,24 g 1,7944 C08DA01 Verapamil (P) 18,35 g 0,24 g 0,0002 C08DB Benzothiazepine derivatives 0,084 C08DB01 (O) 9700,2 g 0,24 g 0,084 C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM 198,341 C09A ACE INHIBITORS, PLAIN 79,4277 C09AA ACE inhibitors, plain 79,4277 C09AA01 Captopril (O) 1299,5 g 0,05 g 0,054 C09AA02 Enalapril (O) 54361,3 g 0,01 g 11,3001 C09AA02 Enalapril (P) 11,2187 g 0,01 g 0,0023 C09AA03 Lisinopril (O) 6 g 0,01 g 0,0012 C09AA04 Perindopril (O) 8384,34 g 0,004 g 4,3571 C09AA05 Ramipril (O) 67997,575 g 2,5 mg 56,5386 C09AA09 Fosinopril (O) 50442,84 g 0,015 g 6,9904 C09AA10 Trandolapril (O) 176,96 g 0,002 g 0,1839 C09B ACE INHIBITORS, COMBINATIONS 47,0601 C09BA ACE inhibitors and diuretics 28,5031 C09BA02 Enalapril+ Hydrochlorothiazide (O) 4188632 pieces 1 pieces 8,7069 C09BA04 Perindopril+ Indapamide (O) 7264620 pieces 1 pieces 15,101 C09BA05 Ramipril+ Hydrochlorothiazide (O) 1465374 pieces 1 pieces 3,0461 C09BA06 Quinapril+ Hydrochlorothiazide (O) 210 pieces 1 pieces 0,0004 C09BA09 Fosinopril+ Hydrochlorothiazide (O) 793150 pieces 1 pieces 1,6487 C09BB ACE inhibitors and calcium channel blockers 10,3933 C09BB03 Lisinopril+ Amlodipine (O) 996060 pieces 1 pieces 2,0705 C09BB04 Perindopril+ Amlodipine (O) 2777580 pieces 1 pieces 5,7738 C09BB07 Ramipril+ Amlodipine (O) 835800 pieces 1 pieces 1,7374 C09BB10 Trandolapril+ Verapamil (O) 390488 pieces 1 pieces 0,8117 C09BX ACE inhibitors, other combinations 8,1637 C09BX01 Perindopril+ Amlodipine+ Indapamide (O) 3927300 pieces 1 pieces 8,1637 C09C ANGIOTENSIN II ANTAGONISTS, PLAIN 41,8611 C09CA Angiotensin II antagonists, plain 41,8611 C09CA01 Losartan (O) 106909,8 g 0,05 g 4,4447 C09CA02 Eprosartan (O) 1562,4 g 0,6 g 0,0054 C09CA03 Valsartan (O) 170280,32 g 0,08 g 4,4245 C09CA06 Candesartan (O) 36555,616 g 0,008 g 9,4985 C09CA07 Telmisartan (O) 401595,84 g 0,04 g 20,8699 C09CA08 Olmesartan medoxomil (O) 25189,08 g 0,02 g 2,618 C09D ANGIOTENSIN II ANTAGONISTS, COMBINATIONS 29,9921 C09DA Angiotensin II antagonists and diuretics 16,1439 C09DA01 Losartan+ Hydrochlorothiazide (O) 1104160 pieces 1 pieces 2,2952 C09DA03 Valsartan+ Hydrochlorothiazide (O) 898688 pieces 1 pieces 1,8681 C09DA06 Candesartan+ Hydrochlorothiazide (O) 1017056 pieces 1 pieces 2,1142 C09DA07 Telmisartan+ Hydrochlorothiazide (O) 4496716 pieces 1 pieces 9,3473 C09DA08 Olmesartan medoxomil+ Hydrochlorothiazide (O) 249736 pieces 1 pieces 0,5191

12/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

C09DB Angiotensin II antagonists and calcium channel blockers 11,18 C09DB01 Valsartan+ Amlodipine (O) 42312 pieces 1 pieces 0,088 C09DB02 Olmesartan medoxomil+ Amlodipine (O) 2139312 pieces 1 pieces 4,447 C09DB04 Telmisartan+ Amlodipine (O) 3129588 pieces 1 pieces 6,5055 C09DB07 Candesartan+ Amlodipine (O) 67144 pieces 1 pieces 0,1396 C09DX Angiotensin II antagonists, other combinations 2,6682 C09DX01 Valsartan+ Amlodipine+ Hydrochlorothiazide (O) 3612 pieces 1 pieces 0,0075 C09DX03 Olmesartan medoxomil+ Amlodipine+ Hydrochlorothiazide (O) 1274784 pieces 1 pieces 2,6499 C09DX04 Valsartan+ Sacubitril (O) 5180 pieces 1 pieces 0,0108 C10 MODIFYING AGENTS 58,1195 C10A LIPID MODIFYING AGENTS, PLAIN 57,4229 C10AA HMG CoA reductase inhibitors 56,5772 C10AA01 Simvastatin (O) 82564,38 g 0,03 g 5,7209 C10AA03 Pravastatin (O) 5440,8 g 0,03 g 0,377 C10AA04 Fluvastatin (O) 20018,88 g 0,06 g 0,6936 C10AA05 Atorvastatin (O) 189288 g 0,02 g 19,6736 C10AA07 Rosuvastatin (O) 144860,27 g 0,01 g 30,1121 C10AB Fibrates 0,5623 C10AB05 Fenofibrate (O) 54102 g 0,2 g 0,5623 C10AC Bile acid sequestrants 0,0007 C10AC01 Colestyramine (O) 4800 g 14 g 0,0007 C10AX Other lipid modifying agents 0,2828 C10AX09 Ezetimibe (O) 1359,4 g 0,01 g 0,2826 C10AX13 (P) 0,84 g 10 mg 0,0002 C10AX80 Omega-3-acid ethyl esters 90 (O) 134456 pieces C10B LIPID MODIFYING AGENTS, COMBINATIONS 0,6965 C10BX HMG CoA reductase inhibitors, other combinations 0,6965 C10BX03 Atorvastatin+ Amlodipine (O) 191970 pieces 1 pieces 0,399 C10BX11 Atorvastatin+ Amlodipine+ Perindopril (O) 143100 pieces 1 pieces 0,2975 D DERMATOLOGICALS 1,7915 D01 FOR DERMATOLOGICAL USE 1,1886 D01A ANTIFUNGALS FOR TOPICAL USE D01AC and derivatives D01AC01 (C) 834217,2 g D01AC05 (C) 209940 g D01AC08 (C) 429364,8 g D01AC08 Ketoconazole (C) 1365240 ml D01AC80 Isoconazole+ Diflucortolone (C) 641370 g D01AE Other antifungals for topical use D01AE14 (C) 10223,4 ml D01AE15 (C) 635951 g D01AE16 (C) 18075 ml D01AE22 (C) 282880 ml D01AE22 Naftifine (C) 315405 g D01B ANTIFUNGALS FOR SYSTEMIC USE 1,1886 D01BA Antifungals for systemic use 1,1886 D01BA01 (O) 622,5 g 0,5 g 0,0026 D01BA02 Terbinafine (O) 142637 g 0,25 g 1,186 D02 EMOLLIENTS AND PROTECTIVES D02A EMOLLIENTS AND PROTECTIVES D02AB Zinc products D02AB80 Zinc oxide (C) 445260 g D02AE Carbamide products D02AE01 (C) 109950 g D02AF preparations D02AF81 Salicylic acid+ Lactic acid (C) 201735 ml D02B PROTECTIVES AGAINST UV-RADIATION

13/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day D02BA Protectives against UV-radiation for topical use D02BA01 4-Aminobenzoic acid (O) 1200 g PREPARATIONS FOR TREATMENT OF WOUNDS AND D03 ULCERS D03A CICATRIZANTS D03AX Other cicatrizants D03AX03 Dexpanthenol (C) 3923390 g D03AX81 Heparin sodium+ Allantoin+ Extract of Cepae (C) 127000 g D03AX83 Dexpanthenol+ (C) 1622610 g D05 ANTIPSORIATICS 0,0589 D05A ANTIPSORIATICS FOR TOPICAL USE D05AC Antracen derivatives D05AC01 Dithranol (C) 3000 g D05AX Other antipsoriatics for topical use D05AX80 Calcipotriol+ (C) 742260 g D05B ANTIPSORIATICS FOR SYSTEMIC USE 0,0589 D05BB Retinoids for treatment of 0,0589 D05BB02 Acitretin (O) 991,5 g 0,035 g 0,0589 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR D06 DERMATOLOGICAL USE D06A ANTIBIOTICS FOR TOPICAL USE D06AA and derivatives D06AA04 Tetracycline (C) 435 g D06AX Other antibiotics for topical use D06AX01 (C) 206220 g D06AX02 (C) 1000 g D06AX07 (C) 15 g D06AX13 Retapamulin (C) 630 g D06AX80 + Neomycin (C) 149920 g D06AX84 Chloramphenicol+ Methyluracil (C) 3600 g D06B CHEMOTHERAPEUTICS FOR TOPICAL USE D06BA Sulfonamides D06BA01 (C) 1704750 g D06BB Antivirals D06BB03 (C) 210440 g D06BB04 (C) 2370 ml D06BB06 (C) 32544 g D06BB10 (C) 4001 g D06BX Other chemotherapeutics D06BX01 Metronidazole (C) 166145 g D06BX02 (C) 0,0002 g D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS D07A CORTICOSTEROIDS, PLAIN D07AA Corticosteroids, weak (group I) D07AA02 Hydrocortisone (C) 646610 g D07AB Corticosteroids, moderately potent (group II) D07AB09 Triamcinolone (C) 72720 g D07AC Corticosteroids, potent (group III) D07AC01 Betamethasone (C) 200400 g D07AC04 (C) 165 g D07AC13 Mometasone (C) 326160 ml D07AC13 Mometasone (C) 1115720 g D07AC14 Methylprednisolone aceponate (C) 557925 g D07AC17 Fluticasone (C) 54105 g D07AD Corticosteroids, very potent (group IV) D07AD01 Clobetasol (C) 90750 ml D07AD01 Clobetasol (C) 900350 g

14/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

D07B CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS D07BA Corticosteroids, weak, combinations with antiseptics D07BA80 Hydrocortisone+ Chlorhexidine (C) 369600 g D07BC Corticosteroids, potent, combinations with antiseptics D07BC80 Betamethasone+ Salicylic acid (C) 465 g D07BC80 Betamethasone+ Salicylic acid (C) 845500 ml D07C CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS D07CA Corticosteroids, weak, combinations with antibiotics D07CA83 Hydrocortisone+ Fusidic acid (C) 82020 g D07CC Corticosteroids, potent, combinations with antibiotics D07CC80 Betamethasone+ Fusidic acid (C) 527940 g D07CC83 Betamethasone+ Gentamicin (C) 200 g D07X CORTICOSTEROIDS, OTHER COMBINATIONS D07XA Corticosteroids, weak, other combinations D07XA81 + Salicylic acid (C) 213100 ml D07XC Corticosteroids, potent, other combinations D07XC03 Mometasone+ Salicylic acid (C) 171135 g D08 ANTISEPTICS AND D08A ANTISEPTICS AND DISINFECTANTS D08AC Biguanides and amidines D08AC02 Chlorhexidine (C) 500 ml D08AG products D08AG02 Povidone, iodinated (C) 960770 ml D08AG02 Povidone, iodinated (C) 3188230 g D08AG03 Iodine (C) 828530 ml D08AJ Quaternary ammonium compounds D08AJ81 Octenidine+ Phenoxyethanol (C) 8623300 ml D08AX Other antiseptics and disinfectants D08AX82 Tar+ Castor oil+ Xeroformium (C) 21660 g D08AX83 Brilliant Green (C) 321960 ml D10 ANTI-ACNE PREPARATIONS 0,4996 D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE D10AD Retinoids for topical use in acne D10AD01 Tretinoin (C) 27300 g D10AD03 Adapalene (C) 153180 g D10AF Antiinfectives for treatment of acne D10AF01 (C) 464640 ml D10AF02 Erythromycin (C) 134050 ml D10AF81 Clindamycin+ Benzoyl peroxide (C) 207405 g D10AF82 Clindamycin+ Tretinoin (C) 161970 g D10AX Other anti-acne preparations for topical use D10AX03 Azelaic acid (C) 349230 g D10B ANTI-ACNE PREPARATIONS FOR SYSTEMIC USE 0,4996 D10BA Retinoids for treatment of acne 0,4996 D10BA01 (O) 7210,2 g 0,03 g 0,4996 D11 OTHER DERMATOLOGICAL PREPARATIONS 0,0444 D11A OTHER DERMATOLOGICAL PREPARATIONS 0,0444 D11AH Agents for , excluding corticosteroids D11AH01 (C) 56640 g D11AH02 (C) 169680 g D11AX Other dermatologicals 0,0444 D11AX01 (C) 170820 ml D11AX10 (O) 21,364 g 0,001 g 0,0444 D11AX16 (C) 600 g D11AX21 (C) 3650 g D11AX22 (C) 39240 g G GENITO AND SEX 53,7018

15/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day G01 GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS 0,6222 ANTIINFECTIVES AND ANTISEPTICS, EXCL. G01A 0,6222 COMBINATIONS WITH CORTICOSTEROIDS G01AA Antibiotics 0,075 G01AA10 Clindamycin (V) 3610 g 0,1 g 0,075 G01AA80 Nystatin+ Neomycin+ (V) 84 pieces G01AF Imidazole derivatives 0,5471 G01AF01 Metronidazole (V) 19544 g 0,5 g 0,0813 G01AF02 Clotrimazole (V) 16837,6 g 0,1 g 0,35 G01AF05 (V) 5574,3 g 0,1 g 0,1159 G02 OTHER GYNECOLOGICALS 4,257 G02A UTEROTONICS 0,012 G02AB Ergot alkaloids 0,0052 G02AB01 Methylergometrine (P) 0,502 g 0,2 mg 0,0052 G02AD Prostaglandins 0,0068 G02AD02 Dinoprostone (P) 0,4 g G02AD02 Dinoprostone (V) 1,6362 g 0,5 mg 0,0068 G02AD06 (O) 8,0968 g G02B CONTRACEPTIVES FOR TOPICAL USE 2,9092 G02BA Intrauterine contraceptives 0,0155 G02BA03 (V) 7466 pieces 1 pieces 0,0155 G02BB Intravaginal contraceptives 2,8937 G02BB01 + (V) 48510 pieces 0,036 pieces 2,801 G02BB80 Nonoxinol (V) 24 pieces 1 pieces <0,0001 G02BB81 Benzalkonium chloride (V) 44560 pieces 1 pieces 0,0926 G02BB81 (V) 76032 g G02C OTHER GYNECOLOGICALS 1,3358 G02CA Sympathomimetics, labour repressants G02CA80 Hexoprenaline (P) 0,034 g G02CB Prolactine inhibitors 0,1647 G02CB01 Bromocriptine (O) 354,975 g 0,005 g 0,1476 G02CB03 Cabergoline (O) 4,108 g 0,5 mg 0,0171 G02CX Other gynecologicals 1,1711 G02CX03 Agni casti fructus (O) 356340 pieces 1 pieces 0,7407 G02CX04 Cimicifugae rhizoma (O) 414090 pieces 2 pieces 0,4304 SEX HORMONES AND MODULATORS OF THE GENITAL G03 31,6672 SYSTEM G03A HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE 25,5787 G03AA and , fixed combinations 21,659 G03AA07 Levonorgestrel+ Ethinylestradiol (O) 92421 pieces 1 pieces 0,1921 G03AA09 + Ethinylestradiol (O) 569205 pieces 0,75 pieces 1,5776 G03AA10 + Ethinylestradiol (O) 83216 pieces 1 pieces 0,173 G03AA10 Gestodene+ Ethinylestradiol (O) 2443707 pieces 0,75 pieces 6,773 G03AA12 + Ethinylestradiol (O) 985796 pieces 1 pieces 2,0492 G03AA12 Drospirenone+ Ethinylestradiol (O) 2103402 pieces 0,75 pieces 5,8298 G03AA13 + Ethinylestradiol (TD) 93429 pieces 0,107 pieces 1,8151 G03AA14 Nomegestrol+ (O) 20328 pieces 1 pieces 0,0423 G03AA15 Chlormadinone+ Ethinylestradiol (O) 209307 pieces 0,75 pieces 0,5801 G03AA16 + Ethinylestradiol (O) 319088 pieces 1 pieces 0,6633 G03AA16 Dienogest+ Ethinylestradiol (O) 708477 pieces 0,75 pieces 1,9636 G03AB Progestogens and estrogens, sequential preparations 0,4357 G03AB03 Levonorgestrel+ Ethinylestradiol (O) 103005 pieces 0,75 pieces 0,2855 G03AB05 Desogestrel+ Ethinylestradiol (O) 8184 pieces 0,75 pieces 0,0227 G03AB08 Dienogest+ (O) 61348 pieces 1 pieces 0,1275 G03AC Progestogens 3,4103 G03AC08 Etonogestrel (P) 34,68 g 68 mcg 1,0601 G03AC09 Desogestrel (O) 1130612 pieces 1 pieces 2,3502 G03AD Emergency contraceptives 0,0737 G03AD01 Levonorgestrel (O) 51,765 g 1,5 mg 0,0717

16/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day G03AD02 Ulipristal (O) 27,9 g 0,03 g 0,0019 G03B 0,2179 G03BA 3-oxoandrosten (4) derivatives 0,2179 G03BA03 (C) 4,5 g 0,05 g 0,0002 G03BA03 Testosterone (O) 24 g 0,12 g 0,0004 G03BA03 Testosterone (P) 1881,5 g 0,018 g 0,2173 G03C ESTROGENS 1,5855 G03CA Natural and semisynthetic estrogens, plain 1,4253 G03CA03 Estradiol (C, V) 113400 g G03CA03 Estradiol (O) 676,676 g 2 mg 0,7033 G03CA03 Estradiol (TD) 3,8192 g 0,05 mg 0,1588 G03CA03 Estradiol (TD) 29,4 g 1 mg 0,0611 G03CA03 Estradiol (TD) 85,3373 g G03CA03 Estradiol (V) 2,754 g 0,025 mg 0,229 G03CA04 (O) 0,54 g 0,002 g 0,0006 G03CA04 Estriol (V) 26,22 g 0,2 mg 0,2725 G03CA80 Estradiol+ Prednisolone (C) 77250 g G03CX Other estrogens 0,1602 G03CX01 (O) 192,71 g 2,5 mg 0,1602 G03D PROGESTOGENS 1,2832 G03DA Pregnen (4) derivatives 0,5581 G03DA02 Medroxyprogesterone (O) 33,64 g 0,005 g 0,014 G03DA02 Medroxyprogesterone (P) 455,1 g 0,007 g 0,1351 G03DA04 (O) 32781 g 0,3 g 0,2271 G03DA04 Progesterone (P) 223,25 g 0,005 g 0,0928 G03DA04 Progesterone (V) 3855,6 g 0,09 g 0,0891 G03DB Pregnadien derivatives 0,7251 G03DB01 (O) 2921,8 g 0,01 g 0,6074 G03DB08 Dienogest (O) 113,288 g 2 mg 0,1177 G03F PROGESTOGENS AND ESTROGENS IN COMBINATION 2,0158 G03FA Progestogens and estrogens, fixed combinations 1,5557 G03FA01 + Estradiol (O) 510440 pieces 1 pieces 1,0611 G03FA14 Dydrogesterone+ Estradiol (O) 84252 pieces 1 pieces 0,1751 G03FA17 Drospirenone+ Estradiol (O) 153720 pieces 1 pieces 0,3195 G03FB Progestogens and estrogens, sequential preparations 0,4601 G03FB05 Norethisterone+ Estradiol (O) 181272 pieces 1 pieces 0,3768 G03FB06 Medroxyprogesterone+ Estradiol (O) 84 pieces 1 pieces 0,0002 G03FB08 Dydrogesterone+ Estradiol (O) 39984 pieces 1 pieces 0,0831 G03G AND OTHER OVULATION STIMULANTS 0,3557 G03GA Gonadotropins 0,1249 G03GA01 Chorionic gonadotrophin (P) 275000 U 250 U 0,0023 G03GA05 Follitropin alfa (P) 3750150 U 75 U 0,1039 G03GA06 Follitropin beta (P) 42600 U 75 U 0,0012 G03GA07 Lutropin alfa (P) 345975 U 75 U 0,0096 G03GA08 Choriogonadotropin alfa (P) 0,7847 g 0,25 mg 0,0065 G03GA09 Corifollitropin alfa (P) 0,0109 g 0,15 mg 0,0002 G03GA30 Follitropin alfa+ Lutropin alfa (P) 590 doses 1 doses 0,0012 G03GB Ovulation stimulants, synthetic 0,2309 G03GB02 (O) 999,5 g 0,009 g 0,2309 G03H 0,545 G03HA Antiandrogens, plain 0,1349 G03HA01 Cyproterone (O) 6487,5 g 0,1 g 0,1349 G03HB Antiandrogens and estrogens 0,4102 G03HB01 Cyproterone+ (O) 147987 pieces 0,75 pieces 0,4102 OTHER SEX HORMONES AND MODULATORS OF THE G03X 0,0853 GENITAL SYSTEM G03XA and similar agents 0,0007

17/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day G03XA01 (O) 206 g 0,6 g 0,0007 G03XB Progesterone receptor modulators 0,0846 G03XB01 (O) 801 g 0,6 g 0,0028 G03XB02 Ulipristal (O) 196,84 g 5 mg 0,0818 G04 UROLOGICALS 17,1554 G04B UROLOGICALS 2,6774 G04BD Drugs for urinary frequency and incontinence 1,4728 G04BD04 (O) 5072,7 g 0,015 g 0,703 G04BD07 (O) 491,596 g 0,004 g 0,2555 G04BD08 (O) 136,95 g 0,005 g 0,0569 G04BD09 (O) 3685,5 g 0,04 g 0,1915 G04BD12 (O) 6395,25 g 50 mg 0,2659 G04BE Drugs used in 1,1924 G04BE01 Alprostadil (P) 0,033 g 0,02 mg 0,0034 G04BE01 Alprostadil (urethral) 1,779 g 0,25 mg 0,0148 G04BE03 (O) 22006,2 g 0,05 g 0,9149 G04BE03 Sildenafil (P) 0,15 g G04BE08 (O) 905,2 g 0,01 g 0,1882 G04BE09 (O) 101,36 g 0,01 g 0,0211 G04BE10 Avanafil (O) 2407,8 g 0,1 g 0,0501 G04BX Other urologicals 0,0122 G04BX14 Dapoxetin (O) 176,13 g 0,03 g 0,0122 G04BX15 sodium (O) 12,5 g G04BX80 Centaury+ Lovage root+ Rosemary leaf (O) 789960 pieces G04BX90 Extr. prostatae (P) 995 pieces G04C DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY 14,478 G04CA Alpha-adrenoreceptor antagonists 11,4152 G04CA01 Alfuzosin (O) 7600,5 g 7,5 mg 2,1066 G04CA02 Tamsulosin (O) 1247,604 g 0,4 mg 6,4835 G04CA04 Silodosin (O) 37,92 g 8 mg 0,0099 G04CA52 Tamsulosin+ (O) 1354350 pieces 1 pieces 2,8153 G04CB Testosterone-5-alpha reductase inhibitors 0,5842 G04CB01 Finasteride (O) 353,03 g 0,005 g 0,1468 G04CB02 Dutasteride (O) 105,21 g 0,5 mg 0,4374 G04CX Other drugs used in benign prostatic hypertrophy 2,4787 G04CX02 Sabalis serrulatae fructus (O) 381571,2 g 0,32 g 2,4787 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX H 28,1882 HORMONES AND INSULINS PITUITARY AND HYPOTHALAMIC HORMONES AND H01 0,415 ANALOGUES LOBE HORMONES AND H01A 0,1401 ANALOGUES H01AA ACTH 0,0003 H01AA02 Tetracosactide (P) 0,0375 g 0,25 mg 0,0003 H01AB Thyrotropin 0,0009 H01AB01 Thyrotropin alfa (P) 0,3996 g 0,9 mg 0,0009 H01AC Somatropin and somatropin agonists 0,1205 H01AC01 Somatropin (P) 115952,2713 U 2 U 0,1205 H01AX Other anterior pituitary lobe hormones and analogues 0,0184 H01AX01 (P) 88,35 g 0,01 g 0,0184 H01B LOBE HORMONES 0,1694 H01BA and analogues 0,0948 H01BA01 Vasopressin injection (P) 13000 U 4 U 0,0068 H01BA02 (N) 0,0307 g 0,025 mg 0,0026 H01BA02 Desmopressin (P) 0,0251 g 0,004 mg 0,013 H01BA02 Desmopressin (SL) 8,3682 g 0,24 mg 0,0725 H01BB and analogues 0,0746 H01BB01 (O) 2101000 U 100 U 0,0437

18/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day H01BB02 Oxytocin (P) 223150 U 15 U 0,0309 H01C HYPOTHALAMIC HORMONES 0,1055 H01CA -releasing hormones H01CA01 (P) 0,0023 g H01CB and analogues 0,0903 H01CB02 (P) 15,9885 g 0,7 mg 0,0475 H01CB03 (P) 61,86 g 3 mg 0,0429 H01CC Anti-gonadotropin-releasing hormones 0,0152 H01CC01 (P) 1,377 g 0,25 mg 0,0114 H01CC02 (P) 0,4473 g 0,25 mg 0,0037 H02 CORTICOSTEROIDS FOR SYSTEMIC USE 8,2207 H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN 8,2139 H02AA Mineralocorticoids 0,1357 H02AA02 Fludrocortisone (O) 6,53 g 0,1 mg 0,1357 H02AB 8,0782 H02AB01 Betamethasone (P) 18,5342 g 1,5 mg 0,0257 H02AB02 (O) 598,415 g 1,5 mg 0,8293 H02AB02 Dexamethasone (P) 670,4 g 1,5 mg 0,929 H02AB04 Methylprednisolone (O) 6740,8 g 7,5 mg 1,8683 H02AB04 Methylprednisolone (P) 5162,6 g 0,02 g 0,5366 H02AB06 Prednisolone (O) 12641,5 g 0,01 g 2,6278 H02AB06 Prednisolone (P) 2646,75 g 0,01 g 0,5502 H02AB08 Triamcinolone (O) 14,4 g 7,5 mg 0,004 H02AB08 Triamcinolone (P) 1640,4 g 7,5 mg 0,4547 H02AB09 Hydrocortisone (O) 3212,05 g 0,03 g 0,2226 H02AB09 Hydrocortisone (P) 435,3 g 0,03 g 0,0302 H02B CORTICOSTEROIDS FOR SYSTEMIC USE, COMBINATIONS 0,0068 H02BX Corticosteroids for systemic use, combinations 0,0068 H02BX80 Hydrocortisone+ Lidocaine (P) 97,625 g 0,03 g 0,0068 H03 THERAPY 19,5133 H03A THYROID PREPARATIONS 18,0854 H03AA 18,0854 H03AA01 sodium (O) 1304,9525 g 0,15 mg 18,084 H03AA02 (O) 0,04 g 0,06 mg 0,0014 H03AA03 Levothyroxine sodium+ Liothyronine (O) 300 pieces H03AA04 (O) 1,785 g H03B ANTITHYROID PREPARATIONS 1,4279 H03BA Thiouracils 0,5871 H03BA02 (O) 28245 g 0,1 g 0,5871 H03BB -containing imidazole derivatives 0,8407 H03BB02 (O) 4044,5 g 0,01 g 0,8407 H04 PANCREATIC HORMONES 0,0008 H04A GLYCOGENOLYTIC HORMONES 0,0008 H04AA Glycogenolytic hormones 0,0008 H04AA01 Glucagon (P) 0,397 g 0,001 g 0,0008 H05 CALCIUM HOMEOSTASIS 0,0383 H05B ANTI-PARATHYROID AGENTS 0,0383 H05BX Other anti-parathyroid agents 0,0383 H05BX01 Cinacalcet (O) 761,88 g 0,06 g 0,0264 H05BX02 Paricalcitol (O) 0,0115 g 2 mcg 0,0119 J ANTIINFECTIVES FOR SYSTEMIC USE 20,4964 J01 ANTIBACTERIALS FOR SYSTEMIC USE 13,5497 J01A 1,3174 J01AA Tetracyclines 1,3174 J01AA02 (O) 63326 g 0,1 g 1,3164 J01AA02 Doxycycline (P) 5 g 0,1 g 0,0001 J01AA07 Tetracycline (O) 138 g 1 g 0,0003 J01AA12 Tigecycline (P) 30,5 g 0,1 g 0,0006

19/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day J01C BETA-LACTAM ANTIBACTERIALS, PENICILLINS 5,6669 J01CA Penicillins with extended spectrum 2,4721 J01CA01 Ampicillin (O) 342 g 2 g 0,0004 J01CA01 Ampicillin (P) 17100 g 2 g 0,0178 J01CA04 Amoxicillin (O) 1180527 g 1 g 2,454 J01CE Beta-lactamase sensitive penicillins 0,1904 J01CE01 Benzylpenicillin (P) 33030 g 3,6 g 0,0191 J01CE02 Phenoxymethylpenicillin (O) 164061 g 2 g 0,1705 J01CE08 Benzathine benzylpenicillin (P) 1407,6 g 3,6 g 0,0008 J01CE80 Benzathine benzylpenicillin+ benzylpenicillin (P) 47,7 g J01CF Beta-lactamase resistant penicillins 0,1164 J01CF04 Oxacillin (P) 111950 g 2 g 0,1164 J01CF05 Flucloxacillin (O) 90 g 2 g 0,0001 J01CR Combinations of penicillins, incl. beta-lactamase inhibitors 2,8879 J01CR01 Ampicillin+ Sulbactam (P) 158756 g 6 g 0,055 J01CR02 Amoxicillin+ Clavulanic acid (O) 1244980,8 g 1 g 2,5879 J01CR02 Amoxicillin+ Clavulanic acid (P) 167025 g 3 g 0,1157 J01CR04 Sultamicillin (O) 71136 g 1,5 g 0,0986 J01CR05 Piperacillin+ Tazobactam (P) 206576 g 14 g 0,0307 J01D OTHER BETA-LACTAM ANTIBACTERIALS 1,7505 J01DB First-generation cephalosporins 0,2442 J01DB04 Cefazolin (P) 98430 g 3 g 0,0682 J01DB05 Cefadroxil (O) 169357 g 2 g 0,176 J01DC Second-generation cephalosporins 1,3642 J01DC01 Cefoxitin (P) 10200 g 6 g 0,0035 J01DC02 Cefuroxime (O) 257017,5 g 0,5 g 1,0685 J01DC02 Cefuroxime (P) 324151,5 g 3 g 0,2246 J01DC10 Cefprozil (O) 32496 g 1 g 0,0675 J01DD Third-generation cephalosporins 0,0544 J01DD01 Cefotaxime (P) 47690 g 4 g 0,0248 J01DD02 Ceftazidime (P) 20820 g 4 g 0,0108 J01DD04 Ceftriaxone (P) 18040 g 2 g 0,0187 J01DD81 Ceftazidime+ Avibactam (P) 40 g 4 g <0,0001 J01DE Fourth-generation cephalosporins 0,0224 J01DE01 Cefepime (P) 21550 g 2 g 0,0224 J01DH Carbapenems 0,0651 J01DH02 Meropenem (P) 29575 g 2 g 0,0307 J01DH03 Ertapenem (P) 8803 g 1 g 0,0183 J01DH51 Imipenem+ Cilastatin (P) 15485 g 2 g 0,0161 J01DI Other cephalosporins and penems 0,0001 J01DI54 Ceftolozane+ Tazobactam (P) 180 g 3 g 0,0001 J01E SULFONAMIDES AND 0,4617 J01EA Trimethoprim and derivatives 0,0253 J01EA01 Trimethoprim (O) 4872 g 0,4 g 0,0253 Combinations of sulfonamides and trimethoprim, incl. J01EE 0,4363 derivatives J01EE01 + Trimethoprim (O) 10020 pieces 4 pieces 0,0052 J01EE01 Sulfamethoxazole+ Trimethoprim (O) 373980 pieces 2 pieces 0,3887 J01EE01 Sulfamethoxazole+ Trimethoprim (O) 736300 ml 40 ml 0,0383 J01EE01 Sulfamethoxazole+ Trimethoprim (P) 40100 ml 20 ml 0,0042 J01F , LINCOSAMIDES AND 2,4187 J01FA Macrolides 2,2412 J01FA01 Erythromycin (O) 74,6 g 1 g 0,0002 J01FA02 Spiramycin (O) 7,5 g 3 g <0,0001 J01FA09 Clarithromycin (O) 404542,5 g 0,5 g 1,6818 J01FA09 (P) 2721,5 g 1 g 0,0057

20/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day J01FA10 Azithromycin (O) 79888,3 g 0,3 g 0,5535 J01FF Lincosamides 0,1775 J01FF01 Clindamycin (O) 93967,2 g 1,2 g 0,1628 J01FF01 Clindamycin (P) 12715,8 g 1,8 g 0,0147 J01G ANTIBACTERIALS 0,0415 J01GA 0,0104 J01GA01 (P) 5025 g 1 g 0,0104 J01GB Other 0,0311 J01GB01 Tobramycin (I) 150,528 g 0,112 g 0,0028 J01GB01 Tobramycin (I) 184,8 g 0,3 g 0,0013 J01GB01 Tobramycin (P) 64 g 0,24 g 0,0006 J01GB03 Gentamicin (P) 2384,4 g 0,24 g 0,0207 J01GB06 (P) 2795 g 1 g 0,0058 J01M QUINOLONE ANTIBACTERIALS 1,0067 J01MA Fluoroquinolones 1,0067 J01MA01 (O) 3612 g 0,4 g 0,0188 J01MA02 (O) 307150 g 1 g 0,6385 J01MA02 Ciprofloxacin (P) 13826 g 0,5 g 0,0575 J01MA06 (O) 71136 g 0,8 g 0,1848 J01MA12 (O) 11585 g 0,5 g 0,0482 J01MA12 Levofloxacin (P) 385,5 g 0,5 g 0,0016 J01MA14 (O) 10874 g 0,4 g 0,0565 J01MA14 Moxifloxacin (P) 172,8 g 0,4 g 0,0009 J01X OTHER ANTIBACTERIALS 0,8864 J01XA Glycopeptide antibacterials 0,02 J01XA01 (P) 19211,5 g 2 g 0,02 J01XA02 Teicoplanin (P) 2 g 0,4 g <0,0001 J01XB Polymyxins 0,0105 J01XB01 Colistin (I, P) 12740000000 U 3000000 U 0,0088 J01XB01 (P) 2450000000 U 3000000 U 0,0017 J01XC Steroid antibacterials 0,0002 J01XC01 Fusidic acid (O) 175 g 1,5 g 0,0002 J01XD Imidazole derivatives 0,2793 J01XD01 Metronidazole (O) 228322,5 g 2 g 0,2373 J01XD01 Metronidazole (P) 30297,5 g 1,5 g 0,042 J01XE derivatives 0,5653 J01XE01 (O) 54389 g 0,2 g 0,5653 J01XX Other antibacterials 0,0111 J01XX01 Fosfomycin (O) 630 g 3 g 0,0004 J01XX01 Fosfomycin (P) 139 g 8 g <0,0001 J01XX07 Nitroxoline (O) 72,5 g 1 g 0,0002 J01XX08 (O) 5088 g 1,2 g 0,0088 J01XX08 Linezolid (P) 960 g 1,2 g 0,0017 J01XX81 Dioxydine (P) 16 g J02 ANTIMYCOTICS FOR SYSTEMIC USE 0,3496 J02A ANTIMYCOTICS FOR SYSTEMIC USE 0,3496 J02AA Antibiotics 0,0092 J02AA01 Amphotericin (O) 300 g J02AA01 Amphotericin (P) 154,8 g 0,035 g 0,0092 J02AC Triazole derivatives 0,3334 J02AC01 (O) 12371,2 g 0,2 g 0,1286 J02AC01 Fluconazole (P) 2724,5 g 0,2 g 0,0283 J02AC02 (O) 15325 g 0,2 g 0,1593 J02AC03 (O) 938 g 0,4 g 0,0049 J02AC03 Voriconazole (P) 131,8 g 0,4 g 0,0007 J02AC04 (O) 1688,4 g 0,3 g 0,0117 J02AX Other antimycotics for systemic use 0,007 J02AX04 (P) 72,87 g 0,05 g 0,003 J02AX05 (P) 4,2 g 0,1 g 0,0001

21/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day J02AX06 (P) 185,7 g 0,1 g 0,0039 J04 0,3135 J04A DRUGS FOR TREATMENT OF TUBERCULOSIS 0,2931 J04AB Antibiotics 0,0614 J04AB01 (O) 7000 g 0,75 g 0,0194 J04AB02 (O) 11100 g 0,6 g 0,0385 J04AB02 Rifampicin (P) 114 g 0,6 g 0,0004 J04AB04 (O) 225 g 0,15 g 0,0031 J04AC Hydrazides 0,1039 J04AC01 (O) 15000 g 0,3 g 0,1039 J04AD Thiocarbamide derivatives 0,0166 J04AD01 Protionamide (O) 6000 g 0,75 g 0,0166 J04AK Other drugs for treatment of tuberculosis 0,1112 J04AK01 (O) 30000 g 1,5 g 0,0416 J04AK02 (O) 40200 g 1,2 g 0,0696 J04B DRUGS FOR TREATMENT OF LEPRA 0,0204 J04BA Drugs for treatment of lepra 0,0204 J04BA01 Clofazimine (O) 180 g 0,1 g 0,0037 J04BA02 (O) 400 g 0,05 g 0,0166 J05 ANTIVIRALS FOR SYSTEMIC USE 6,2835 J05A DIRECT ACTING ANTIVIRALS 6,2835 and excl. reverse transcriptase J05AB 0,282 inhibitors J05AB01 Aciclovir (O) 122608 g 4 g 0,0637 J05AB01 Aciclovir (P) 2822,5 g 4 g 0,0015 J05AB04 (O) 24096,8 g 1 g 0,0501 J05AB06 (P) 210 g 0,5 g 0,0009 J05AB11 (O) 230668 g 3 g 0,1598 J05AB14 (O) 2619 g 0,9 g 0,006 J05AD Phosphonic acid derivatives 0,0001 J05AD01 sodium (P) 300 g 6,5 g 0,0001 J05AE Protease inhibitors 0,1043 J05AE03 (O) 6960 g 1,2 g 0,0121 J05AE10 (O) 53264 g 1,2 g 0,0923 J05AF and reverse transcriptase inhibitors 0,0668 J05AF01 (O) 190 g 0,6 g 0,0007 J05AF01 Zidovudine (P) 9 g 0,6 g <0,0001 J05AF05 Lamivudine (O) 1015,2 g 0,3 g 0,007 J05AF06 (O) 1903,2 g 0,6 g 0,0066 J05AF07 (O) 29,4 g 0,245 g 0,0002 J05AF10 (O) 12,57 g 0,5 mg 0,0523 J05AG Non-nucleoside reverse transcriptase inhibitors 1,1276 J05AG03 (O) 175770 g 0,6 g 0,609 J05AG05 (O) 6237,75 g 25 mg 0,5187 J05AH Neuraminidase inhibitors 0,163 J05AH01 (I) 3,6 g 0,02 g 0,0004 J05AH02 (O) 11733,75 g 0,15 g 0,1626 J05AR Antivirals for treatment of HIV , combinations 4,0628 J05AR01 Zidovudine+ (O) 98640 pieces 2 pieces 0,1025 J05AR02 Lamivudine+ Abacavir (O) 579540 pieces 1 pieces 1,2047 J05AR03 Tenofovir disoproxil+ (O) 691110 pieces 1 pieces 1,4366 + + Emtricitabine+ Tenofovir disoproxil J05AR09 14490 pieces 1 pieces 0,0301 (O) J05AR10 + Ritonavir (O) 110640 g 0,8 g 0,2875 J05AR14 Darunavir+ Cobicistat (O) 481710 pieces 1 pieces 1,0013 J05AX Other antivirals 0,4769 J05AX08 (O) 96252 g 0,8 g 0,2501 J05AX09 (O) 738 g 0,6 g 0,0026

22/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day J05AX12 Dolutegravir (O) 1960,95 g 50 mg 0,0815 J05AX16 (O) 12208 g 0,5 g 0,0508 J05AX67 + + Ritonavir (O) 48888 pieces 2 pieces 0,0508 J05AX68 + (O) 19796 pieces 1 pieces 0,0411 J06 IMMUNE SERA AND IMMUNOGLOBULINS J06A IMMUNE SERA J06AA Immune sera J06AA01 Diphtheria antitoxin (P) 20 pieces J06AA03 Snake venom antiserum (P) 2 pieces J06B IMMUNOGLOBULINS J06BA Immunoglobulins, normal human J06BA01 Immunoglobulins, normal human, for extravascular a (P) 9820,8 g

J06BA02 Immunoglobulins, normal human, for intravascular a (P) 64700 g J06BB Specific immunoglobulins J06BB01 Human Anti-D Immunoglobulin (P) 2104250 U J06BB03 Varicella zoster immunoglobulin (P) 3500 U J06BB04 B immunoglobulin (P) 4160 U J06BB05 Rabies immunoglobulin (P) 3000 U J06BB09 Cytomegalovirus immunoglobulin (P) 110000 U J06BB16 (P) 45,05 g J06BB21 Bezlotoxumab (P) 1 g J07 VACCINES J07A BACTERIAL VACCINES J07AE Cholera vaccines J07AE01 Cholera, inactivated, whole cell (O) 34 doses J07AG Hemophilus influenzae B vaccines J07AG01 Haemophilus influenzae B, purified conjugated (P) 156 doses J07AH Meningococcal vaccines Meningococcus, tetravalent purified polysaccharides antigen J07AH08 477 doses conjugated (P) J07AH09 Meningococcus B, multicomponent vaccine (P) 34 doses J07AL Pneumococcal vaccines J07AL01 Pneumococcus, purified polysaccharides antigen (P) 50 doses Pneumococcus, purified polysaccharides antigen conjugated J07AL02 1764 doses (P) Pneumococcus, purified polysaccharides antigen+ J07AL52 337 doses Haemophilus influenzae, conjugated (P) J07AM Tetanus vaccines J07AM51 Tetanus toxoid+ Diphtheria toxoid (P) 33120 doses J07AN Tuberculosis vaccines J07AN01 Tuberculosis, live attenuated (P) 22800 doses J07AP Typhoid vaccines J07AP03 Typhoid, purified polysaccharide antigen (P) 1974 doses J07AX Other bacterial vaccines J07AX80 Diphtheria-tetanus-pertussis (P) 12858 doses J07B VIRAL VACCINES J07BA Encephalitis vaccines J07BA01 Encephalitis, tick borne, inactivated, whole (P) 62701 doses J07BB vaccines J07BB02 Influenza, inactivated, split virus or surface antigen (P) 77548 doses J07BC Hepatitis vaccines J07BC01 , purified antigen (P) 43505 doses J07BC02 Hepatitis A, inactivated, whole virus (P) 6352 doses Hepatitis A, inactivated, whole virus+ Hepatitis B, purified J07BC80 2913 doses antigen (P) J07BD Measles vaccines

23/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day Measles, live attunated+ Rubella, live attenuated+ Mumps, J07BD52 28688 doses live,attenuated (P) J07BF Poliomyelitis vaccines J07BF03 Poliomyelitis, trivalent, inactivated, whole virus (P) 788 doses J07BG Rabies vaccines J07BG01 Rabies, inactivated, whole virus (P) 2524 doses J07BH Rota virus vaccines J07BH01 Rota virus, live attenuated (O) 10895 doses J07BH02 Rota virus, pentavalent, live, reassorted (O) 16654 doses J07BK Varicella zoster vaccines J07BK01 Varicella, live attenuated (P) 1389 doses J07BK02 Zoster, live attenuated (P) 19 doses J07BL Yellow fever vaccines J07BL01 Yellow fever, live attenuated (P) 1128 doses J07BM Papillomavirus vaccines J07BM01 Papillomavirus (human types 6, 11, 16, 18) (P) 112 doses J07BM02 Papillomavirus (human types 16, 18) (P) 272 doses Papillomavirus (human types 6, 11, 16, 18, 31, 33, 45, 52, 58) J07BM03 4856 doses (P) J07C BACTERIAL AND VIRAL VACCINES, COMBINED J07CA Bacterial and viral vaccines, combined Diphtheria toxoid+ Pertussis, purified antigen+ Tetanus J07CA02 16394 doses toxoid+ Poliomyelitis, trivalent, inactivated, whole virus (P)

Diphtheria toxoid+ Tetanus toxoid+ Pertussis, purified J07CA06 antigen+ Poliomyelitis, trivalent, inactivated, whole virus+ 51700 doses Haemophilus influenzae B, purified antigen conjugated (P)

Diphtheria toxoid+ Poliomyelitis, trivalent, inactivated, whole virus+ Pertussis, purified antigen+ Haemophilus influenzae B, J07CA09 2600 doses purified antigen conjugated+ Hepatitis B, purified antigen+ Tetanus toxoid (P) L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS 11,4168 L01 ANTINEOPLASTIC AGENTS L01A ALKYLATING AGENTS L01AA Nitrogen mustard analogues L01AA01 Cyclophosphamide (O) 715 g L01AA01 Cyclophosphamide (P) 4260,5 g L01AA02 Chlorambucil (O) 26,25 g L01AA03 Melphalan (O) 12,1 g L01AA03 Melphalan (P) 17,9 g L01AA06 Ifosfamide (P) 2359 g L01AA09 Bendamustine (P) 129,15 g L01AB Alkyl sulfonates L01AB01 Busulfan (O) 4,2 g L01AB01 Busulfan (P) 7,68 g L01AB02 Treosulfan (P) 650 g L01AD Nitrosoureas L01AD01 Carmustine (P) 13 g L01AD02 Lomustine (O) 21,2 g L01AX Other alkylating agents L01AX03 Temozolomide (O) 707,275 g L01AX04 Dacarbazine (P) 410 g L01B ANTIMETABOLITES L01BA Folic acid analogues L01BA01 Methotrexate (P) 1498,85 g L01BA04 Pemetrexed (P) 477,7 g L01BB Purine analogues L01BB02 Mercaptopurine (O) 397 g

24/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day L01BB03 Tioguanine (O) 8 g L01BB04 Cladribine (P) 0,15 g L01BB05 (O) 1 g L01BB05 Fludarabine (P) 170,5 g L01BB06 Clofarabine (P) 0,2 g L01BB07 Nelarabine (P) 3 g L01BC Pyrimidine analogues L01BC01 (P) 2057 g L01BC02 Fluorouracil (P) 15225 g L01BC05 Gemcitabine (P) 5549,2592 g L01BC06 Capecitabine (O) 267708 g L01BC07 Azacitidine (P) 137,2 g L01BC83 + Tipiracil (O) 1920 pieces L01C PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS L01CA Vinca alkaloids and analogues L01CA01 Vinblastine (P) 2,34 g L01CA02 Vincristine (P) 3,081 g L01CA04 Vinorelbine (O) 3 g L01CA04 Vinorelbine (P) 18,5 g L01CB Podophyllotoxin derivatives L01CB01 (O) 328 g L01CB01 Etoposide (P) 463,9 g L01CD Taxanes L01CD01 Paclitaxel (P) 751,6 g L01CD02 Docetaxel (P) 397,12 g L01CD04 Cabazitaxel (P) 4,86 g L01CX Other plant alkaloids and natural products L01CX01 Trabectedin (P) 0,003 g L01D CYTOTOXIC ANTIBIOTICS AND RELATED SUBSTANCES L01DA Actinomycines L01DA01 Dactinomycin (P) 0,025 g L01DB Anthracyclines and related substances L01DB01 Doxorubicin (P) 110,64 g L01DB02 Daunorubicin (P) 7,23 g L01DB03 Epirubicin (P) 277 g L01DB06 Idarubicin (P) 1,88 g L01DB07 Mitoxantrone (P) 3,4 g L01DB11 Pixantrone (P) 3,016 g L01DC Other cytotoxic antibiotics L01DC01 Bleomycin (P) 6690000 U L01DC03 Mitomycin (P) 4,26 g L01X OTHER ANTINEOPLASTIC AGENTS L01XA Platinum compounds L01XA01 Cisplatin (P) 214,1 g L01XA02 Carboplatin (P) 1953,3 g L01XA03 Oxaliplatin (P) 862,2 g L01XB Methylhydrazines L01XB01 Procarbazine (O) 200 g L01XC Monoclonal antibodies L01XC02 Rituximab (P) 2069,484 g L01XC03 Trastuzumab (P) 1741,5 g L01XC06 Cetuximab (P) 87,3 g L01XC07 (P) 1242,7 g L01XC08 Panitumumab (P) 130,2 g L01XC10 Ofatumumab (P) 31,2 g L01XC12 Brentuximab vedotin (P) 6,35 g L01XC13 Pertuzumab (P) 69,3 g

25/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day L01XC14 Trastuzumab emtansine (P) 0,2 g L01XC15 Obinutuzumab (P) 16 g L01XC17 Nivolumab (P) 30,3 g L01XC18 Pembrolizumab (P) 33,9 g L01XC21 (P) 2 g L01XC24 Daratumumab (P) 73,6 g L01XD Sensitizers used in photodynamic/ L01XD04 Aminolevulinic acid (O) 27 g L01XE Protein kinase inhibitors L01XE01 Imatinib (O) 15060 g L01XE02 Gefitinib (O) 1095 g L01XE03 Erlotinib (O) 441 g L01XE04 Sunitinib (O) 269,85 g L01XE05 Sorafenib (O) 4457,6 g L01XE06 Dasatinib (O) 549 g L01XE07 Lapatinib (O) 367,5 g L01XE08 Nilotinib (O) 6294,4 g L01XE09 Temsirolimus (P) 2,64 g L01XE10 Everolimus (O) 10,35 g L01XE11 Pazopanib (O) 9666 g L01XE12 Vandetanib (O) 36 g L01XE13 Afatinib (O) 41,44 g L01XE14 Bosutinib (O) 100,8 g L01XE16 Crizotinib (O) 705 g L01XE17 Axitinib (O) 65,128 g L01XE18 Ruxolitinib (O) 143,92 g L01XE21 regorafenib (O) 50,4 g L01XE23 Dabrafenib (O) 3492 g L01XE24 Ponatinib (O) 10,8 g L01XE25 Trametinib (O) 21,78 g L01XE27 Ibrutinib (O) 2154,6 g L01XE29 Lenvatinib (O) 0,72 g L01XE31 Nintedanib (O) 3225 g L01XE35 Osimertinib (O) 92,8 g L01XX Other antineoplastic agents L01XX01 Amsacrine (P) 1,125 g L01XX02 Asparaginase (P) 2350000 U L01XX05 (O) 210200 g L01XX11 Estramustine (O) 126 g L01XX14 Tretinoin (O) 20 g L01XX17 Topotecan (P) 3,746 g L01XX19 Irinotecan (P) 629 g L01XX23 Mitotane (O) 1050 g L01XX24 Pegaspargase (P) 318750 U L01XX27 Arsenic trioxide (P) 0,1 g L01XX32 Bortezomib (P) 4,396 g L01XX35 (O) 0,65 g L01XX41 Eribulin (P) 0,3089 g L01XX45 Carfilzomib (P) 1,08 g L01XX46 Olaparib (O) 1993,6 g L01XX50 Ixazomib (O) 0,9 g L02 ENDOCRINE THERAPY 5,0527 L02A HORMONES AND RELATED AGENTS 0,4993 L02AB Progestogens 0,012 L02AB02 Medroxyprogesterone (O) 5775 g 1 g 0,012 L02AE Gonadotropin releasing analogues 0,4873 L02AE01 (N) 5,22 g 1,2 mg 0,009 L02AE03 (P) 7,5528 g 0,129 mg 0,1217 L02AE04 (P) 0,2009 g 0,1 mg 0,0042

26/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day L02AE04 Triptorelin (P) 22,7138 g 0,134 mg 0,3524 L02B HORMONE ANTAGONISTS AND RELATED AGENTS 4,5534 L02BA Anti-estrogens 0,7985 L02BA01 (O) 6116,4 g 0,02 g 0,6357 L02BA03 (P) 650 g 8,3 mg 0,1628 L02BB Anti-androgens 2,1617 L02BB03 (O) 36597,4 g 0,05 g 1,5215 L02BB04 49,28 g 0,16 mg 0,6402 (O) L02BG Aromatase inhibitors 1,5395 L02BG03 (O) 255,024 g 1 mg 0,5301 L02BG04 (O) 1052,025 g 2,5 mg 0,8747 L02BG06 (O) 1619,25 g 0,025 g 0,1346 L02BX Other hormone antagonists and related agents 0,0537 L02BX03 Abiraterone (O) 25830 g 1 g 0,0537 L03 0,8613 L03A IMMUNOSTIMULANTS 0,8613 L03AA Colony stimulating factors 0,0623 L03AA02 Filgrastim (P) 6,8647 g 0,35 mg 0,0408 L03AA13 Pegfilgrastim (P) 3,108 g 0,3 mg 0,0215 L03AB 0,6599 L03AB04 alfa-2a (P) 36588000000 U 2000000 U 0,038 L03AB07 Interferon beta-1a (P) 0,884 g 0,0043 mg 0,4273 L03AB08 Interferon beta-1b (P) 1,7784E+11 U 4000000 U 0,0924 L03AB10 Peginterferon alfa-2b (P) 0,0552 g 0,0075 mg 0,0153 L03AB11 Peginterferon alfa-2a (P) 0,5118 g 0,026 mg 0,0409 L03AB13 Peginterferon beta-1a (P) 0,1966 g 8,9 mcg 0,0459 L03AX Other immunostimulants 0,1391 L03AX03 BCG (P) 3,2 g 1,8 mg 0,0037 L03AX13 Glatiramer acetate (P) 1302,16 g 0,02 g 0,1353 L03AX16 Plerixafor (P) 0,408 g 16,8 mg 0,0001 L03AX80 Methyluracil (O) 1000 g L03AX80 Methyluracil (R) 910 g L04 IMMUNOSUPPRESSANTS 5,5028 L04A IMMUNOSUPPRESSANTS 5,5028 L04AA Selective immunosuppressants 0,917 L04AA03 Antilymphocyte immunoglobulin (horse) (P) 26,25 g L04AA04 Rabbit anti-T-lymphocyte immunoglobulin (P) 9,375 g 0,1 g 0,0002 L04AA06 Mycophenolic acid (O) 247372 g 2 g 0,2571 L04AA06 Mycophenolic acid (P) 200 g 2 g 0,0002 L04AA10 Sirolimus (O) 17,61 g 0,003 g 0,0122 L04AA13 Leflunomide (O) 4364,1 g 0,02 g 0,4536 L04AA18 Everolimus (O) 0,48 g 1,5 mg 0,0007 L04AA23 Natalizumab (P) 108,6 g 0,01 g 0,0226 L04AA24 Abatacept (P) 116,75 g 0,027 g 0,009 L04AA27 Fingolimod (O) 5,992 g 0,5 mg 0,0249 L04AA31 Teriflunomide (O) 738,136 g 14 mg 0,1096 L04AA33 Vedolizumab (P) 56,1 g 5,4 mg 0,0216 L04AA34 Alemtuzumab (P) 0,336 g 0,13 mg 0,0054 L04AB alpha (TNF-alpha) inhibitors 0,8665 L04AB01 Etanercept (P) 504,064 g 0,007 g 0,1497 L04AB02 Infliximab (P) 785,9 g 3,75 mg 0,4356 L04AB04 Adalimumab (P) 270,16 g 2,9 mg 0,1936 L04AB05 Certolizumab pegol (P) 33,6 g 14 mg 0,005 L04AB06 Golimumab (P) 65,9 g 1,66 mg 0,0825 L04AC Interleukin inhibitors 0,1944 L04AC02 Basiliximab (P) 1,9 g 0,04 g 0,0001 L04AC03 Anakinra (P) 61,908 g 0,1 g 0,0013 L04AC05 Ustekinumab (P) 23,225 g 0,54 mg 0,0894

27/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day L04AC07 Tocilizumab (P) 666,472 g 0,02 g 0,0693 L04AC10 Secukinumab (P) 165,3 g 10 mg 0,0344 L04AC16 Guselkumab (P) 0,2 g L04AD Calcineurin inhibitors 0,4229 L04AD01 (O) 30047,5 g 0,25 g 0,2498 L04AD01 Ciclosporin (P) 50,5 g 0,25 g 0,0004 L04AD02 Tacrolimus (O) 414,95 g 5 mg 0,1725 L04AD02 Tacrolimus (P) 0,35 g 5 mg 0,0001 L04AX Other immunosuppressants 3,1019 L04AX01 Azathioprine (O) 27345 g 0,15 g 0,3789 L04AX02 (O) 1124,2 g 0,1 g 0,0234 L04AX03 Methotrexate (O) 3176 g 2,5 mg 2,6408 L04AX03 Methotrexate (P) 0,75 g L04AX04 Lenalidomide (O) 222,285 g 0,01 g 0,0462 L04AX05 Pirfenidone (O) 14398,776 g 2,4 g 0,0125 Pomalidomide L04AX06 0,252 g 3 mg 0,0002 (O) M MUSCULO-SKELETAL SYSTEM 80,2573 M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS 68,2461 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, M01A 68,2373 NON-STEROIDS M01AB derivatives and related substances 9,8286 M01AB01 Indometacin (O) 4678,75 g 0,1 g 0,0973 M01AB05 (O) 408154,375 g 0,1 g 8,4843 M01AB05 Diclofenac (P) 12643,875 g 0,1 g 0,2628 M01AB05 Diclofenac (R) 17465,125 g 0,1 g 0,363 M01AB15 (P) 24,9 g 30 mg 0,0017 M01AB16 (O) 36062 g 0,2 g 0,3748 M01AB82 Diclofenac+ Omeprazole (O) 11769,75 g 0,1 g 0,2447 M01AC Oxicams 4,8997 M01AC01 Piroxicam (O) 2040,4 g 0,02 g 0,2121 M01AC05 Lornoxicam (O) 4184,72 g 0,012 g 0,7249 M01AC05 Lornoxicam (P) 15,28 g 0,012 g 0,0026 M01AC06 Meloxicam (O) 28289,475 g 0,015 g 3,9204 M01AC06 Meloxicam (P) 286,35 g 0,015 g 0,0397 M01AE Propionic acid derivatives 37,6078 M01AE01 Ibuprofen (O) 14879549,2 g 1,2 g 25,7751 M01AE02 (O) 503519,4 g 0,5 g 2,0933 M01AE03 (O) 104691,375 g 0,15 g 1,4508 M01AE03 Ketoprofen (P) 14683 g 0,15 g 0,2035 M01AE17 (O) 62385 g 0,075 g 1,7291 M01AE17 Dexketoprofen (P) 4410,75 g 0,075 g 0,1222 M01AE52 Naproxen+ Esomeprazole (O) 1499430 g 0,5 g 6,2337 M01AG Fenamates 0,0039 M01AG02 (O) 568 g 0,3 g 0,0039 M01AH Coxibs 6,9689 M01AH01 (O) 64991 g 0,2 g 0,6755 M01AH05 Etoricoxib (O) 181653,15 g 60 mg 6,2934 M01AX Other antiinflammatory and antirheumatic agents, non-steroids 8,9284 M01AX01 Nabumetone (O) 201240 g 1 g 0,4183 M01AX05 Glucosamine (O) 6140936,67 g 1,5 g 8,5101 M01C SPECIFIC ANTIRHEUMATIC AGENTS 0,0088 M01CC and similar agents 0,0088 M01CC01 Penicillamine (O) 2125 g 0,5 g 0,0088 M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN

28/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN

M02AA Antiinflammatory preparations, non-steroids for topical use M02AA07 Piroxicam (C) 7725 g M02AA10 Ketoprofen (C) 1415200 g M02AA12 Naproxen (C) 917840 g M02AA13 Ibuprofen (C) 1054450 g M02AA15 Diclofenac (C) 35580560 g M02AA15 Diclofenac (TD) 294861 pieces M02AA81 Ibuprofen+ Levomenthol (C) 1606500 g M02AC Preparations with salicylic acid derivatives Methyl salicylate+ Levomenthol+ Eucalyptus oil+ M02AC80 101773 g oil (C) M02AX Other topical products for joint and muscular pain M02AX80 Nicoboxil+ Nonivamide (C) 217080 g M02AX86 Camphor+ Methyl salicylate+ Levomenthol (C) 47100 g Camphor+ Salicylic acid+ Turpentine oil+ Venenum Viperae M02AX90 1261900 g berus (C) Benzyl nicotinate+ Nonivamide+ Camphor+ Turpentine oil+ M02AX92 1140520 g (C) M03 MUSCLE RELAXANTS 0,8983 M03A MUSCLE RELAXANTS, PERIPHERALLY ACTING AGENTS M03AB Choline derivatives M03AB01 (P) 3397 g M03AC Other quaternary ammonium compounds M03AC04 (P) 1549,3 g M03AC06 Pipecuronium (P) 25,1 g M03AC09 (P) 718 g M03AX Other muscle relaxants, peripherally acting agents M03AX01 Botulinum (P) 1040200 U M03B MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS 0,8983 M03BX Other centrally acting agents 0,8983 M03BX01 (O) 3988 g 0,05 g 0,1658 M03BX01 Baclofen (P) 1,6513 g 0,55 mg 0,0062 M03BX02 Tizanidine (O) 4187,34 g 0,012 g 0,7254 M03BX04 (O) 91,5 g 0,2 g 0,001 M03C MUSCLE RELAXANTS, DIRECTLY ACTING AGENTS M03CA Dantrolene and derivatives M03CA01 Dantrolene (P) 0,72 g M04 ANTIGOUT PREPARATIONS 6,298 M04A ANTIGOUT PREPARATIONS 6,298 M04AA Preparations inhibiting uric acid production 6,2857 M04AA01 Allopurinol (O) 992940 g 0,4 g 5,1601 M04AA03 Febuxostat (O) 43322,72 g 0,08 g 1,1257 M04AB Preparations increasing uric acid 0,0096 M04AB03 Benzbromarone (O) 460 g 0,1 g 0,0096 M04AC Preparations with no effect on uric acid metabolism 0,0027 M04AC01 Colchicine (O) 1,275 g 1 mg 0,0027 M05 DRUGS FOR TREATMENT OF BONE DISEASES 4,8149 DRUGS AFFECTING BONE STRUCTURE AND M05B 4,8149 MINERALIZATION M05BA Bisphosphonates 0,9629 M05BA03 Pamidronic acid (P) 26,58 g 0,06 g 0,0009 M05BA04 Alendronic acid (O) 1323,84 g 0,01 g 0,2752 M05BA06 Ibandronic acid (O) 1095,45 g 0,005 g 0,4554 M05BA06 Ibandronic acid (P) 1,35 g 0,006 g 0,0005 M05BA07 Risedronic acid (O) 535,64 g 0,005 g 0,2227

29/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day M05BA08 Zoledronic acid (P) 15,799 g 0,004 g 0,0082 M05BB Bisphosphonates, combinations 2,8053 M05BB03 Alendronic acid+ Colecalciferol (O) 13495,44 g 10 mg 2,8053 M05BX Other drugs affecting bone structure and mineralization 1,0467 M05BX03 Strontium ranelate (O) 28392 g 2 g 0,0295 M05BX04 (P) 161,484 g 0,33 mg 1,0172 N NERVOUS SYSTEM 123,0531 N01 N01A ANESTHETICS, GENERAL N01AB Halogenated hydrocarbons N01AB06 (I) 40100 ml N01AB07 (I) 67920 ml N01AB08 (I) 738000 ml N01AF , plain N01AF03 Thiopental (P) 3578 g N01AH Opioid anesthetics N01AH01 (P) 41,0825 g N01AH06 (P) 11,635 g N01AX Other general anesthetics N01AX03 (P) 163 g N01AX07 Etomidate (P) 69,4 g N01AX10 Propofol (P) 61175 g N01AX11 (P) 100 g N01AX13 (I) 11490000 ml N01AX14 (P) 231 g N01B ANESTHETICS, LOCAL N01BA Esters of aminobenzoic acid N01BA02 Procaine (P) 19,75 g N01BB N01BB01 Bupivacaine (Infilt, P) 2924,05 g N01BB01 Bupivacaine (P) 181 g N01BB02 Lidocaine (C) 20526,5 g N01BB02 Lidocaine (NA) 28800 g N01BB02 Lidocaine (NA) 177500 ml N01BB02 Lidocaine (P) 23545 g N01BB03 Mepivacaine (dental) 1971 g N01BB08 Articaine (P) 1,6 g N01BB09 Ropivacaine (P) 366,4 g N01BB80 Articaine+ Epinephrine (dental) 1170875 ml N01BB80 Articaine+ Epinephrine (O) 177300 ml N01BB81 Bupivacaine+ Epinephrine (P) 349900 ml N01BB82 Lidocaine+ Epinephrine (P) 48240 ml N01BB83 Lidocaine+ Prilocaine (C) 53225 g N01BB86 Lidocaine+ Chlorhexidine (urethral) 1185687,5 g N01BC Esters of benzoic acid N01BC01 (C) 430 g N01BX Other local anesthetics N01BX04 (C) 42,1138 g N02 20,6319 N02A 6,1725 N02AA Natural opium alkaloids 0,6264 N02AA01 (O) 6182,4 g 0,1 g 0,1285 N02AA01 Morphine (P) 554,5 g 0,03 g 0,0384 N02AA05 (O) 13095,95 g 0,075 g 0,363 N02AA08 (O) 6939 g 0,15 g 0,0962 N02AA55 Oxycodone+ (O) 11,7 g 75 mg 0,0003 N02AB Phenylpiperidine derivatives 0,1358 N02AB02 (P, V) 3390 g 0,4 g 0,0176 N02AB03 Fentanyl (O) 3,6512 g

30/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day N02AB03 Fentanyl (SL) 2,483 g 0,6 mg 0,0086 N02AB03 Fentanyl (TD) 63,2858 g 1,2 mg 0,1096 N02AE Oripavine derivatives 0,0001 N02AE01 (TD) 0,0504 g 1,2 mg 0,0001 N02AJ Opioids in combination with non-opioid analgesics 3,2554 N02AJ06 + (O) 4369180 pieces 3 pieces 3,0274 N02AJ13 + Paracetamol (O) 2022 g 150 mg 0,028 N02AJ14 Tramadol+ Dexketoprofen (O) 14430,375 g 150 mg 0,2 N02AX Other opioids 2,1548 N02AX02 Tramadol (O) 305339 g 0,3 g 2,1157 N02AX02 Tramadol (P) 5467 g 0,3 g 0,0379 N02AX02 Tramadol (R) 168,5 g 0,3 g 0,0012 N02AX06 (O) 7,75 g 0,4 g <0,0001 N02B OTHER ANALGESICS AND ANTIPYRETICS 13,7087 N02BA Salicylic acid and derivatives 1,0504 N02BA01 Acetylsalicylic acid (O) 1299952,4 g 3 g 0,9007 N02BA80 Acetylsalicylic acid + Ascorbic acid (O) 215944,6 g 3 g 0,1496 N02BB Pyrazolones 0,0028 N02BB02 sodium (O) 165 g 3 g 0,0001 N02BB02 Metamizole sodium (P) 2740 g 3 g 0,0019 N02BB02 Metamizole sodium (P, V) 1100 g 3 g 0,0008 N02BE Anilides 12,6151 N02BE01 Paracetamol (O) 11855844,1 g 3 g 8,2149 N02BE01 Paracetamol (P) 247712 g 3 g 0,1716 N02BE01 Paracetamol (R) 73945,9 g 3 g 0,0512 N02BE75 Paracetamol+ Guaifenesin+ Phenylephrine (O) 238332 g 3 g 0,1651 Paracetamol+ + Pseudoephedrine+ N02BE81 480100 g 3 g 0,3327 (O) N02BE83 Paracetamol+ (O) 72580 g 3 g 0,0503 N02BE84 Paracetamol+ Phenylephrine+ Ascorbic acid (O) 1190017 g 3 g 0,8246 N02BE85 Paracetamol+ + Ascorbic acid (O) 112244,96 g 3 g 0,0778 Paracetamol+ Phenylephrine+ Terpin hydrate+ Ascorbic acid+ N02BE86 421578 g 3 g 0,2921 Caffeine (O) N02BE87 Paracetamol+ Pseudoephedrine (O) 114825 g 3 g 0,0796 N02BE92 Paracetamol+ Codeine (O) 1109000 g 3 g 0,7684 N02BE94 Paracetamol+ Codeine+ Caffeine (O) 1692606 g 3 g 1,1728 N02BE95 Paracetamol+ Phenylephrine (O) 55910 g 3 g 0,0387 N02BE97 Paracetamol+ Pseudoephedrine+ Dextromethorphan (O) 541522 g 3 g 0,3752 N02BE99 Paracetamol+ Dextromethorphan (O) 60 g 3 g <0,0001 N02BG Other analgesics and antipyretics 0,0404 N02BG07 (O) 7783 g 0,4 g 0,0404 N02C ANTIMIGRAINE PREPARATIONS 0,7507 N02CC Selective serotonin (5HT1) agonists 0,7507 N02CC01 Sumatriptan (N) 1,48 g 0,02 g 0,0002 N02CC01 Sumatriptan (O) 14726,1 g 0,05 g 0,6122 N02CC02 Naratriptan (O) 0,075 g 2,5 mg 0,0001 N02CC03 Zolmitriptan (O) 78,57 g 2,5 mg 0,0653 N02CC04 Rizatriptan (O) 66,16 g 0,01 g 0,0138 N02CC07 Frovatriptan (O) 71,185 g 2,5 mg 0,0592 N03 ANTIEPILEPTICS 9,1037 N03A ANTIEPILEPTICS 9,1037 N03AA Barbiturates and derivatives 0,4273 N03AA02 (O) 18045 g 0,1 g 0,3751 N03AA02 Phenobarbital (P) 90 g 0,1 g 0,0019 N03AA03 (O) 30250 g 1,25 g 0,0503 N03AA80 Benzobarbital (O) 250 g N03AB derivatives 0,0442 N03AB02 (O) 6220 g 0,3 g 0,0431

31/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day N03AB02 Phenytoin (P) 153,75 g 0,3 g 0,0011 N03AD derivatives 0,0119 N03AD01 (O) 7150 g 1,25 g 0,0119 N03AE derivatives 0,6099 N03AE01 (O) 2347,32 g 0,008 g 0,6099 N03AF Carboxamide derivatives 2,9366 N03AF01 (O) 1018705 g 1 g 2,1176 N03AF02 (O) 394005 g 1 g 0,819 N03AG derivatives 1,5061 N03AG01 Valproic acid (O) 1082250 g 1,5 g 1,4998 N03AG01 Valproic acid (P) 647,6 g 1,5 g 0,0009 N03AG04 (O) 5250 g 2 g 0,0055 N03AX Other antiepileptics 3,5677 N03AX03 (O) 1650 g 0,4 g 0,0086 N03AX09 (O) 78461,32 g 0,3 g 0,5437 N03AX11 (O) 32709 g 0,3 g 0,2266 N03AX12 (O) 952915 g 1,8 g 1,1005 N03AX14 (O) 322905 g 1,5 g 0,4475 N03AX14 Levetiracetam (P) 125 g 1,5 g 0,0002 N03AX16 (O) 178309,95 g 0,3 g 1,2355 N03AX17 (O) 270 g 1 g 0,0006 N03AX18 Lacosamide (O) 5,6 g 0,3 g <0,0001 N03AX21 Retigabine (O) 798 g 0,9 g 0,0018 N03AX22 (O) 10,752 g 8 mg 0,0028 N04 ANTI-PARKINSON DRUGS 3,8213 N04A AGENTS 0,6174 N04AA Tertiary amines 0,6174 N04AA01 (O) 2970,2 g 0,01 g 0,6174 N04B DOPAMINERGIC AGENTS 3,2039 N04BA Dopa and dopa derivatives 1,4055 N04BA03 Levodopa + Carbidopa+ Entacapone (O) 62440 g 0,45 g 0,2884 N04BA80 Levodopa + Benserazide (O) 250080 g 0,6 g 0,8664 N04BA81 Levodopa + Carbidopa (intestin) 10752 g N04BA81 Levodopa + Carbidopa (O) 72351,5 g 0,6 g 0,2507 N04BB derivatives 0,3349 N04BB01 (O) 32220 g 0,2 g 0,3349 N04BB01 Amantadine (P) 38 g N04BC Dopamine agonists 0,7137 N04BC04 (O) 946,064 g 0,006 g 0,3278 N04BC05 (O) 441,755 g 2,5 mg 0,3673 N04BC07 (P) 179,6 g 20 mg 0,0187 N04BD Monoamine oxidase type B inhibitors 0,7497 N04BD02 Rasagiline (O) 360,676 g 0,001 g 0,7497 N05 43,5573 N05A ANTIPSYCHOTICS 8,9741 N05AA Phenothiazines with aliphatic side-chain 0,157 N05AA01 (O) 11407,8 g 0,3 g 0,079 N05AA01 Chlorpromazine (P) 55 g 0,1 g 0,0011 N05AA02 Levomepromazine (O) 11011 g 0,3 g 0,0763 N05AA02 Levomepromazine (P, V) 24,5 g 0,1 g 0,0005 N05AB Phenothiazines with piperazine structure 0,0648 N05AB02 Fluphenazine (P) 4,75 g 0,001 g 0,0099 N05AB03 Perphenazine (O) 464,8 g 0,03 g 0,0322 N05AB03 Perphenazine (P) 109,282 g 0,01 g 0,0227 N05AC Phenothiazines with piperidine structure 0,0019 N05AC01 Periciazine (O) 46,8 g 0,05 g 0,0019 N05AD Butyrophenone derivatives 1,069 N05AD01 (O) 2063,945 g 0,008 g 0,5363 N05AD01 Haloperidol (P) 841,125 g 0,008 g 0,2186

32/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day N05AD03 Melperone (O) 42370 g 0,3 g 0,2936 N05AD08 Droperidol (P) 24,75 g 2,5 mg 0,0206 N05AE Indole derivatives 0,1336 N05AE03 Sertindole (O) 759,24 g 0,016 g 0,0986 N05AE04 Ziprasidone (O) 1344,72 g 0,08 g 0,0349 N05AF Thioxanthene derivatives 0,9272 N05AF01 Flupentixol (O) 388,3 g 0,006 g 0,1345 N05AF01 Flupentixol (P) 116,98 g 0,004 g 0,0608 N05AF03 (O) 31745 g 0,3 g 0,22 N05AF05 Zuclopenthixol (O) 1295 g 0,03 g 0,0897 N05AF05 Zuclopenthixol (P) 49 g 0,03 g 0,0034 N05AF05 Zuclopenthixol (P) 3022,2 g 0,015 g 0,4188 N05AG Diphenylbutylpiperidine derivatives 0,0002 N05AG02 (O) 0,3 g 0,004 g 0,0002 N05AH Diazepines, oxazepines and thiazepines 4,9849 N05AH02 (O) 88910 g 0,3 g 0,6161 N05AH03 (O) 9281,44 g 0,01 g 1,9293 N05AH03 Olanzapine (P) 96,3 g 0,01 g 0,02 N05AH04 (O) 465576 g 0,4 g 2,4195 N05AL 0,1371 N05AL01 (O) 21912 g 0,8 g 0,0569 N05AL05 Amisulpride (O) 15426 g 0,4 g 0,0802 N05AN 0,2127 N05AN01 Lithium (O) 92100 g 0,9 g 0,2127 N05AX Other antipsychotics 1,2857 N05AX08 (O) 1502,56 g 0,005 g 0,6247 N05AX08 Risperidone (P) 25,5375 g 2,7 mg 0,0197 N05AX12 Aripiprazole (O) 4008,93 g 0,015 g 0,5556 N05AX12 Aripiprazole (P) 7,4978 g 0,015 g 0,001 N05AX12 Aripiprazole (P) 173,2 g 0,0133 g 0,0271 N05AX13 Paliperidone (P) 69,425 g 2,5 mg 0,0577 N05B ANXIOLYTICS 13,5832 N05BA Benzodiazepine derivatives 13,5825 N05BA01 (O) 28575,15 g 0,01 g 5,9399 N05BA01 Diazepam (P) 557,2 g 0,01 g 0,1158 N05BA01 Diazepam (R) 56,525 g 0,01 g 0,0117 N05BA02 (O) 1 g 0,03 g 0,0001 N05BA04 (O) 1219,6 g 0,05 g 0,0507 N05BA06 (O) 458,49 g 2,5 mg 0,3812 N05BA06 Lorazepam (P) 8,52 g 2,5 mg 0,0071 N05BA08 Bromazepam (O) 6355,29 g 0,01 g 1,3211 N05BA09 (O) 243 g 0,02 g 0,0253 N05BA12 Alprazolam (O) 2745,725 g 0,001 g 5,7075 N05BA80 (O) 10,6 g 0,001 g 0,022 N05BB Diphenylmethane derivatives 0,0002 N05BB01 Hydroxyzine (O) 6,325 g 0,075 g 0,0002 N05BE Azaspirodecanedione derivatives 0,0005 N05BE01 (O) 7,8 g 0,03 g 0,0005 N05C HYPNOTICS AND SEDATIVES 21 N05CD Benzodiazepine derivatives 0,6657 N05CD02 (O) 960,9 g 0,005 g 0,3995 N05CD05 Triazolam (O) 3,7975 g 0,25 mg 0,0316 N05CD08 (O) 1179,526 g 0,015 g 0,1635 N05CD08 Midazolam (P) 513,3667 g 0,015 g 0,0711 N05CF Benzodiazepine related drugs 19,9553 N05CF01 Zopiclone (O) 57942,75 g 7,5 mg 16,0594 N05CF02 Zolpidem (O) 18742,2 g 0,01 g 3,8959 N05CH Melatonin receptor agonists 0,0644 N05CH01 Melatonin (O) 61,992 g 2 mg 0,0644

33/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day N05CM Other hypnotics and sedatives 0,3146 N05CM09 Valerianae radix (O) 445380 pieces 3 pieces 0,3086 N05CM18 Dexmedetomidine (P) 2,866 g 1 mg 0,006 N06 PSYCHOANALEPTICS 33,9713 N06A ANTIDEPRESSANTS 28,7966 N06AA Non-selective monoamine inhibitors 1,9606 N06AA02 (O) 27,5 g 0,1 g 0,0006 N06AA04 (O) 3501,45 g 0,1 g 0,0728 N06AA04 Clomipramine (P) 10 g 0,1 g 0,0002 N06AA09 (O) 53833,5 g 0,075 g 1,492 N06AA10 (O) 14252,5 g 0,075 g 0,395 N06AB Selective serotonin reuptake inhibitors 17,4419 N06AB03 Fluoxetine (O) 29667,08 g 0,02 g 3,0834 N06AB04 Citalopram (O) 13725,5 g 0,02 g 1,4266 N06AB05 (O) 22621,2 g 0,02 g 2,3511 N06AB06 Sertraline (O) 94749,6 g 0,05 g 3,9391 N06AB08 Fluvoxamine (O) 347,5 g 0,1 g 0,0072 N06AB10 Escitalopram (O) 31916,2 g 0,01 g 6,6344 N06AF Monoamine oxidase inhibitors, non-selective 0,0012 N06AF04 Tranylcypromine (O) 6 g 0,01 g 0,0012 N06AX Other antidepressants 9,3928 N06AX03 (O) 18 g 0,06 g 0,0006 N06AX11 (O) 29088,99 g 0,03 g 2,0156 N06AX12 Bupropione (O) 72103,5 g 0,3 g 0,4996 N06AX14 Tianeptine (O) 20327,25 g 0,0375 g 1,1268 N06AX16 Venlafaxine (O) 127802,7 g 0,1 g 2,6566 N06AX18 (O) 0,4 g 0,008 g 0,0001 N06AX21 (O) 51720,84 g 0,06 g 1,7919 N06AX22 Agomelatine (O) 11454,8 g 0,025 g 0,9524 N06AX26 Vortioxetine (O) 1679,58 g 10 mg 0,3491 PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND N06B 1,0603 NOOTROPICS N06BA Centrally acting sympathomimetics 0,7809 N06BA04 (O) 10260,54 g 0,03 g 0,711 N06BA07 Modafinil (O) 429 g 0,3 g 0,003 N06BA09 (O) 2571,772 g 0,08 g 0,0668 N06BA11 Dexmethylphenidate (O) 1 g 15 mg 0,0001 N06BC Xanthine derivatives 0,0006 N06BC80 Coffeini- (P) 112 g 0,4 g 0,0006 N06BC81 Caffeine citrate (O, P) 26,6 g N06BX Other psychostimulants and nootropics 0,2788 N06BX03 (O) 303840 g 2,4 g 0,2632 N06BX18 (O) 113 g 15 mg 0,0157 N06BX83 Aminobutyric acid (O) 11615 g N06D ANTI- DRUGS 4,1144 N06DA Anticholinesterases 0,7336 N06DA02 Donepezil (O) 2646,56 g 7,5 mg 0,7335 N06DA04 (O) 0,896 g 0,016 g 0,0001 N06DX Other anti-dementia drugs 3,3808 N06DX01 (O) 2398,48 g 0,02 g 0,2493 N06DX02 Ginkgo folium (O) 180777 g 0,12 g 3,1315 N06DX80 cerebrolysine (P) 19,368 g N07 OTHER NERVOUS SYSTEM DRUGS 11,9675 N07A PARASYMPATHOMIMETICS 0,3527 N07AA Anticholinesterases 0,3527 N07AA01 (P) 29,015 g 0,002 g 0,0302 N07AA02 bromide (O) 26130 g 0,18 g 0,3018 N07AA80 Neostigmine+ Glycopyrronium (P) 10000 ml 1 ml 0,0208 N07B DRUGS USED IN ADDICTIVE DISORDERS 3,3003

34/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day N07BA Drugs used in dependence 1,4922 N07BA01 Nicotine (O) 12871,11 g 0,03 g 0,8918 N07BA01 Nicotine (TD) 3806,621 g 0,014 g 0,5652 N07BA03 (O) 33,8455 g 2 mg 0,0352 N07BB Drugs used in dependence 0,3278 N07BB01 (O) 28425 g 0,2 g 0,2954 N07BB01 Disulfiram (P) 27 g N07BB04 Naltrexone (O) 562,8 g 50 mg 0,0234 N07BB05 (O) 77,868 g 18 mg 0,009 N07BC Drugs used in opioid dependence 1,4802 N07BC02 (O) 17487 g 0,025 g 1,454 N07BC51 Buprenorphine+ Naloxone (SL) 100,968 g 8 mg 0,0262 N07C ANTIVERTIGO PREPARATIONS 8,294 N07CA Antivertigo preparations 8,294 N07CA01 (O) 79975,92 g 0,024 g 6,9269 N07CA02 (O) 58756,25 g 0,09 g 1,3571 N07CA03 (O) 1,35 g 0,01 g 0,0003 N07CA80 Cinnarizine+ (O) 422 g 90 mg 0,0097 N07X OTHER NERVOUS SYSTEM DRUGS 0,0205 N07XX Other nervous system drugs 0,0205 N07XX02 (O) 809,2 g 0,1 g 0,0168 N07XX06 (O) 176,4 g 0,1 g 0,0037 N07XX07 Fampridine (O) 0,56 g 20 mg 0,0001 N07XX81 Idebenone (O) 216 g PRODUCTS, INSECTICIDES AND P 0,9798 REPELLENTS P01 0,7723 AGENTS AGAINST AND OTHER PROTOZOAL P01A 0,0042 DISEASES P01AB derivatives 0,0042 P01AB01 Metronidazole (O) 4041 g 2 g 0,0042 P01B ANTIMALARIALS 0,7681 P01BA Aminoquinolines 0,7404 P01BA02 (O) 183732 g 0,516 g 0,7402 P01BA03 Primaquine (O) 1,5 g 0,015 g 0,0002 P01BB Biguanides 0,0259 P01BB51 + (O) 444 pieces 16 pieces 0,0001 P01BB51 Proguanil+ Atovaquone (O) 49716 pieces 4 pieces 0,0258 P01BC Methanolquinolines 0,0009 P01BC01 (P) 54,098 g 1,5 g 0,0001 P01BC02 (O) 388 g 1 g 0,0008 P01BD Diaminopyrimidines 0,001 P01BD01 (O) 9,75 g 0,075 g 0,0003 P01BD80 Pyrimethamine+ (O) 25 g 0,075 g 0,0007 AGENTS AGAINST AND P01C <0,0001 TRYPANOSOMIASIS P01CX Other agents against leishmaniasis and <0,0001 P01CX01 Pentamidine isethionate (I) 0,9 g 0,28 g <0,0001 P02 ANTHELMINTICS 0,2075 P02B ANTITREMATODALS 0,0003 P02BA derivatives and related substances 0,0003 P02BA01 Praziquantel (O) 457,2 g 3 g 0,0003 P02C ANTINEMATODAL AGENTS 0,2072 P02CA derivatives 0,2071 P02CA01 Mebendazole (O) 17821 g 0,2 g 0,1852 P02CA03 (O) 4204,8 g 0,4 g 0,0219 P02CF Avermectines 0,0001 P02CF01 Ivermectin (O) 0,744 g 12 mg 0,0001

35/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day ECTOPARASITICIDES, INCL. SCABICIDES, INSECTICIDES P03 AND REPELLENTS P03A ECTOPARASITICIDES, INCL. SCABICIDES P03AC Pyrethrines, incl. synthetic compounds P03AC04 Permethrin (C) 24640 g P03AC81 Allethrin+ Piperonyl butoxid (C) 2000 g P03AX Other ectoparasiticides, incl. scabicides P03AX01 Benzyl benzoate (C) 416370 g R RESPIRATORY SYSTEM 88,2238 R01 NASAL PREPARATIONS 36,1989 DECONGESTANTS AND OTHER NASAL PREPARATIONS R01A 33,6319 FOR TOPICAL USE R01AA Sympathomimetics, plain 22,2002 R01AA05 Oxymetazoline (N) 263,625 g 0,4 mg 1,37 R01AA07 Xylometazoline (N) 8016,635 g 0,8 mg 20,8302 R01AB Sympathomimetics, combinations excl. corticosteroids 2,5582 R01AB83 Xylometazoline+ (N) 242620 ml 0,8 ml 0,6304 R01AB85 Xylometazoline+ Dexpanthenol (N) 741920 ml 0,8 ml 1,9278 R01AC Antiallergic agents, excl. corticosteroids 0,3091 R01AC03 Azelastine (N) 83,28 g 0,56 mg 0,3091 R01AD Corticosteroids 8,5643 R01AD01 (N) 18,29 g 0,4 mg 0,095 R01AD05 Budesonide (N) 73,5779 g 0,2 mg 0,7647 R01AD08 Fluticasone (N) 85,452 g 0,2 mg 0,8881 R01AD09 Mometasone (N) 339,549 g 0,2 mg 3,5291 R01AD12 Fluticasone furoate (N) 153,9417 g 0,11 mg 2,9091 R01AD81 Fluticasone+ Azelastine (N) 727800 doses 4 doses 0,3782 R01AX Other nasal preparations R01AX06 (N) 15 g R01AX83 Retinol+ Tocopherol (N) 175240 ml R01B NASAL DECONGESTANTS FOR SYSTEMIC USE 2,5671 R01BA Sympathomimetics 2,5671 R01BA02 Pseudoephedrine (O) 165373,68 g 0,24 g 1,4323 R01BA81 Pseudoephedrine+ (O) 29366,28 g 0,24 g 0,2543 R01BA84 Pseudoephedrine+ Guaifenesin (O) 11708,4 g 0,24 g 0,1014 R01BA89 Pseudoephedrine+ Loratadine (O) 16652,16 g 0,24 g 0,1442 R01BA93 Pseudoephedrine+ Cetirizine (O) 73283,28 g 0,24 g 0,6347 R02 THROAT PREPARATIONS 2,6445 R02A THROAT PREPARATIONS 2,6445 R02AA Antiseptics 2,1778 R02AA06 Cetylpyridinium chloride (O) 175158 pieces R02AA82 + Cetylpyridinium chloride (O) 820680 ml R02AA82 Benzydamine+ Cetylpyridinium chloride (O) 1223184 pieces 6 pieces 0,4238 R02AA89 Povidone, iodinated+ Allantoin (O) 341610 ml R02AA92 + Cinchocaine (O) 1194820 pieces 6 pieces 0,4139 R02AA94 Amylmetacresol+ Dichlorobenzyl alcohol (O) 805776 pieces 6 pieces 0,2792 R02AA95 Amylmetacresol+ Dichlorobenzyl alcohol+ Levomenthol (O) 1991568 pieces 6 pieces 0,69

R02AA96 Amylmetacresol+ Dichlorobenzyl alcohol+ Ascorbic acid (O) 467016 pieces 6 pieces 0,1618 R02AA98 Cetylpyridinium chloride+ Benzocaine (O) 376410 ml R02AA98 Cetylpyridinium chloride+ Benzocaine (O) 556452 pieces 6 pieces 0,1928 Benzalkonium chloride+ Eucalyptus oil+ Levomenthol+ R02AA99 47250 pieces 6 pieces 0,0164 Peppermint oil+ Thymol (O) R02AD Anesthetics, local 0,2008 R02AD80 Lidocaine+ Propyl parahydroxybenzoate (O) 579540 pieces 6 pieces 0,2008 R02AX Other throat preparations 0,2659 R02AX01 (O) 5627,93 g 44 mg 0,2659 R02AX80 Thyme herb+ Sage leaf (O) 30075 ml

36/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES 25,7737 R03A , INHALANTS 17,9068 R03AC Selective beta-2-adrenoceptor agonists 4,6398 R03AC02 Salbutamol (I) 1008,888 g 0,8 mg 2,6215 R03AC02 Salbutamol (I) 1737,7 g 0,01 g 0,3612 R03AC04 Fenoterol (I) 76,8 g 0,6 mg 0,2661 R03AC12 Salmeterol (I) 6,438 g 0,1 mg 0,1338 R03AC13 Formoterol (I) 8,5881 g 0,024 mg 0,7438 R03AC18 Indacaterol (I) 37,044 g 0,15 mg 0,5134 Adrenergics in combination with corticosteroids or other drugs, R03AK 10,8755 excl. anticholinergics R03AK06 Salmeterol+ Fluticasone (I) 670560 doses 4 doses 0,3485 R03AK06 Salmeterol+ Fluticasone (I) 2914440 doses 2 doses 3,0291 R03AK07 Formoterol+ Budesonide (I) 1076040 doses 2 doses 1,1184 R03AK07 Formoterol+ Budesonide (I) 5635560 doses 4 doses 2,9287 R03AK08 Formoterol+ Beclometasone (I) 2147760 doses 4 doses 1,1161 R03AK10 Vilanterol+ Fluticasone furoate (I) 1109160 doses 1 doses 2,3056 R03AK13 Salbutamol+ Beclometasone (I) 56000 doses 4 doses 0,0291 R03AL adrenergics in combination with anticholinergics 2,3916 R03AL01 Fenoterol+ Ipratropium bromide (I) 150460 ml 16 ml 0,0195 R03AL01 Fenoterol+ Ipratropium bromide (I) 2190200 doses 6 doses 0,7588 R03AL03 Vilanterol+ Umeclidinium (I) 177360 doses 1 doses 0,3687 R03AL04 Indacaterol+ Glycopyrronium (I) 251610 doses 1 doses 0,523 R03AL05 Formoterol+ Aclidinium (I) 278760 doses 2 doses 0,2897 R03AL06 Olodaterol+ Tiotropium (I) 415440 doses 2 doses 0,4318 OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, R03B 4,8053 INHALANTS R03BA Glucocorticoids 1,7201 R03BA01 Beclometasone (I) 0,1 g 1,5 mg 0,0001 R03BA01 Beclometasone (I) 0,9 g 0,8 mg 0,0023 R03BA02 Budesonide (I) 149,36 g 1,5 mg 0,207 R03BA02 Budesonide (I) 339,98 g 0,8 mg 0,8834 R03BA05 Fluticasone (I) 181,062 g 0,6 mg 0,6273 R03BB Anticholinergics 3,0852 R03BB01 Ipratropium bromide (I) 26,565 g 0,3 mg 0,1841 R03BB01 Ipratropium bromide (I) 26,688 g 0,12 mg 0,4623 R03BB04 Tiotropium (I) 3,3763 g 0,005 mg 1,4037 R03BB05 Aclidinium (I) 136,6504 g 0,644 mg 0,4411 R03BB06 Glycopyrronium (I) 11,4721 g 44 mcg 0,542 R03BB07 Umeclidinium (I) 1,3777 g 55 mcg 0,0521 R03C ADRENERGICS FOR SYSTEMIC USE 0,1905 R03CC Selective beta-2-adrenoceptor agonists 0,1905 R03CC02 Salbutamol (O) 1098,36 g 0,012 g 0,1903 R03CC02 Salbutamol (P) 0,2855 g 0,012 g <0,0001 R03CC03 Terbutaline (O) 1,4 g 0,015 g 0,0002 OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY R03D 2,8711 DISEASES R03DA Xanthines 1,3811 R03DA04 (O) 261060 g 0,4 g 1,3567 R03DA05 (O) 67,5 g 0,6 g 0,0002 R03DA05 Aminophylline (P) 6972,2 g 0,6 g 0,0242 R03DC Leukotriene receptor antagonists 1,4614 R03DC03 Montelukast (O) 7030,352 g 0,01 g 1,4614 R03DX Other systemic drugs for obstructive airway diseases 0,0286 R03DX05 Omalizumab (P) 173,25 g 0,016 g 0,0225 R03DX09 Mepolizumab (P) 10,6 g 3,6 mg 0,0061 R05 COUGH AND COLD PREPARATIONS 8,0949 EXPECTORANTS, EXCL. COMBINATIONS WITH COUGH R05C 7,9364 SUPPRESSANTS

37/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day R05CA Expectorants 0,099 R05CA03 Guaifenesin (O) 42870,6 g 0,9 g 0,099 R05CA12 Hederae helicis folium (O) 131930 pieces R05CA12 Hederae helicis folium (O) 8808890 ml R05CA86 Iceland moss (O) 8849400 ml Distillate of rectified essential oils of eucalyptus, sweet orange, R05CA87 1377860 pieces myrtle and lemon (O) R05CA88 Thyme herb+ Wild thyme+ Plantain (O) 515300 ml R05CA89 Thyme herb+ Hederae helicis folium (O) 279300 ml R05CA91 Thyme herb+ Marshmallow root (O) 4607310 ml R05CA92 Thyme herb (O) 249320 pieces R05CB Mucolytics 7,8374 R05CB01 (O) 1052790 g 0,5 g 4,3769 R05CB01 Acetylcysteine (P) 7878 g R05CB02 Bromhexine (O) 8257,28 g 0,024 g 0,7152 R05CB03 Carbocisteine (O) 203097,5 g 1,5 g 0,2815 R05CB06 Ambroxol (O) 141267,3 g 0,12 g 2,4471 R05CB13 Dornase alfa (I) 20,16 g 2,5 mg 0,0168 COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH R05D 0,1061 EXPECTORANTS R05DA Opium alkaloids and derivatives 0,0002 R05DA04 Codeine (O) 10 g 0,1 g 0,0002 R05DB Other cough suppressants 0,1059 R05DB09 Oxeladin (O) 4073,75 g 0,08 g 0,1059 COUGH SUPPRESSANTS AND EXPECTORANTS, R05F 0,0524 COMBINATIONS R05FA Opium derivatives and expectorants 0,0524 R05FA80 Codeine+ Guaifenesin (O) 756600 ml 30 ml 0,0524 R05X OTHER COLDPREPARATIONS R05XA Other cold combination preparations Gentian root+ Primula flower+ Common sorrel+ Elder flower+ R05XA80 3985,6 g Verbena herb (O) Gentian root+ Primula flower+ Common sorrel+ Elder flower+ R05XA80 1939160 pieces Verbena herb (O) R05XA82 Ibuprofen+ Pseudoephedrine (O) 8654,4 g R06 FOR SYSTEMIC USE 15,5115 R06A ANTIHISTAMINES FOR SYSTEMIC USE 15,5115 R06AA Aminoalkyl ethers 0,4694 R06AA02 (O) 109 g 0,2 g 0,0011 R06AA02 Diphenhydramine (P) 22 g R06AA04 (O) 398,12 g 0,002 g 0,4138 R06AA04 Clemastine (P) 52,41 g 0,002 g 0,0545 R06AE Piperazine derivatives 7,2632 R06AE07 Cetirizine (O) 32734,51 g 0,01 g 6,8045 R06AE09 Levocetirizine (O) 1103,275 g 0,005 g 0,4587 R06AX Other antihistamines for systemic use 7,7789 R06AX13 Loratadine (O) 18835,6 g 0,01 g 3,9154 R06AX15 Mebhydrolin (O) 40 g 0,2 g 0,0004 R06AX17 Ketotifen (O) 3,57 g 0,002 g 0,0037 R06AX22 Ebastine (O) 5687,2 g 0,01 g 1,1822 R06AX27 Desloratadine (O) 3398,06 g 0,005 g 1,4127 R06AX28 Rupatadine (O) 954,88 g 0,01 g 0,1985 R06AX29 Bilastine (O) 10256,6 g 20 mg 1,066 R07 OTHER RESPIRATORY SYSTEM PRODUCTS 0,0003 R07A OTHER RESPIRATORY SYSTEM PRODUCTS 0,0003 R07AA Lung surfactants 0,0003 R07AA81 Porcine lung phospholipids (endotrach) 22,56 g 0,16 g 0,0003 S SENSORY ORGANS 31,8355 S01 OPHTHALMOLOGICALS 31,8355

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ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day S01A ANTIINFECTIVES S01AA Antibiotics S01AA01 Chloramphenicol (S) 204820 ml S01AA12 Tobramycin (S) 36050 ml S01AA12 Tobramycin (S) 52650,5 g S01AA13 Fusidic acid (S) 52730 g S01AD Antivirals S01AD03 Aciclovir (S) 3330 g S01AE Fluoroquinolones S01AE03 Ciprofloxacin (S) 18485 ml S01AE05 Levofloxacin (S) 29730 ml S01AE07 Moxifloxacin (S) 15195 ml S01AX Other antiinfectives S01AX15 Propamidine (S) 100 ml S01B ANTIINFLAMMATORY AGENTS S01BA Corticosteroids, plain S01BA01 Dexamethasone (S) 125 pieces S01BA01 Dexamethasone (S) 9206 g S01BA01 Dexamethasone (S) 127715 ml S01BA02 Hydrocortisone (S) 4713 g S01BA09 Clobetasone (S) 500 ml S01BA14 Loteprednol (S) 5400 ml S01BC Antiinflammatory agents, non-steroids S01BC10 Nepafenac (S) 22565 ml S01BC11 Bromfenac (S) 25 ml ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN S01C COMBINATION S01CA Corticosteroids and antiinfectives in combination S01CA80 Dexamethasone+ Neomycin+ Polymyxin B (S) 51100 ml S01CA81 Dexamethasone+ Tobramycin (S) 14602 g S01CA81 Dexamethasone+ Tobramycin (S) 37535 ml S01CA82 Dexamethasone+ Chloramphenicol (S) 42532 g S01CA82 Dexamethasone+ Chloramphenicol (S) 427180 ml S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS 31,8355 S01EA Sympathomimetics in glaucoma therapy 0,0111 S01EA05 Brimonidine (S) 1070 ml 0,2 ml 0,0111 S01EB Parasympathomimetics 0,0145 S01EB01 hydrochloride (S) 2145 ml 0,4 ml 0,0111 S01EB02 (S) 637,5 ml 0,4 ml 0,0033 S01EC Carbonic anhydrase inhibitors 3,3481 S01EC01 (O) 20875 g 0,75 g 0,0579 S01EC01 Acetazolamide (P) 67 g 0,75 g 0,0002 S01EC03 Dorzolamide (S) 117600 ml 0,3 ml 0,8149 S01EC04 Brinzolamide (S) 147105 ml 0,2 ml 1,5289 S01EC80 Brinzolamide+ Brimonidine (S) 91045 ml 0,2 ml 0,9463 S01ED Beta blocking agents 19,8344 S01ED01 Timolol (S) 55180 ml 0,2 ml 0,5735 S01ED01 Timolol (S) 211795 g 40 mg 11,0065 S01ED02 Betaxolol (S) 94705 ml 0,2 ml 0,9843 S01ED80 Timolol+ Dorzolamide (S) 288645 ml 0,2 ml 3 S01ED81 Timolol+ Travoprost (S) 37230 ml 0,2 ml 0,3869 S01ED82 Timolol+ Bimatoprost (S) 109347 ml 0,2 ml 1,1365 S01ED83 Timolol+ Brinzolamide (S) 199435 ml 0,2 ml 2,0728 S01ED84 Timolol+ Latanoprost (S) 60972,5 ml 0,2 ml 0,6337 S01ED85 Timolol+ Tafluprost (S) 3859,2 ml 0,2 ml 0,0401 S01EE analogues 8,6274 S01EE01 Latanoprost (S) 258877,5 ml 0,1 ml 5,3813 S01EE03 Bimatoprost (S) 141 ml 0,1 ml 0,0029 S01EE04 Travoprost (S) 92960 ml 0,1 ml 1,9324

39/42 Estonian Statistics on Medicines 2017

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day S01EE05 Tafluprost (S) 189180 ml 0,3 ml 1,3108 S01F MYDRIATICS AND CYCLOPLEGICS S01FA Anticholinergics S01FA01 Atropine (S) 320 ml S01FA04 (S) 35100 ml S01FA06 (S) 17280 ml S01FB Sympathomimetics excl. antiglaucoma preparations S01FB01 Phenylephrine (S) 6700 ml S01G DECONGESTANTS AND ANTIALLERGICS S01GA Sympathomimetics used as decongestants S01GA02 Tetryzoline (S) 323820 ml S01GX Other antiallergics S01GX01 (S) 97430 ml S01GX07 Azelastine (S) 25290 ml S01GX09 Olopatadine (S) 16675 ml S01H LOCAL ANESTHETICS S01HA Local anesthetics S01HA03 (S) 11770 ml S01HA04 Proxymetacaine (S) 44475 ml S01J DIAGNOSTIC AGENTS S01JA Colouring agents S01JA01 Fluorescein (P) 6000 ml S01JA01 Fluorescein (S) 980 ml S01JA81 Fluorescein+ Oxybuprocaine+ Chlorobutanol (S) 1860 ml S01K SURGICAL AIDS S01KA Viscoelastic substances S01KA02 Hypromellose (S) 5460 g S01L OCULAR VASCULAR DISORDER AGENTS S01LA Antineovascularisation agents S01LA04 (S) 26 pieces S01LA05 aflibercept (S) 165 pieces S01X OTHER OPHTHALMOLOGICALS S01XA Other ophthalmologicals S01XA03 Sodium chloride (S) 122,5 g S01XA18 Ciclosporin (S) 1827 ml S01XA80 Retinol+ Dexpanthenol (S) 8225 g S01XA81 Carbomer (S) 189260 g S01XA82 Hypromellose (S) 186070 ml S01XA85 Hypromellose+ Dextran (S) 460650 ml S01XA86 cytochrome C+ Adenosine+ Nicotinamide (S) 80 ml S02 OTOLOGICALS CORTICOSTEROIDS AND ANTIINFECTIVES IN S02C COMBINATION S02CA Corticosteroids and antiinfectives in combination S02CA81 Dexamethasone+ Neomycin+ Acetic acid, glacial (A) 1440 ml S02CA82 Hydrocortisone+ Ciprofloxacin (A) 136970 ml S02D OTHER OTOLOGICALS S02DA Analgesics and anesthetics S02DA81 + Lidocaine (A) 1860 ml T HERBAL MEDICINAL PRODUCTS T01 HERBAL MEDICINAL PRODUCTS T01R HERBAL MEDICINAL PRODUCTS T01RS Herbal medicinal products T01RS01 herbal preparation (O) 728970 pieces T01RS01 herbal preparation (O) 14646280 ml T01RS02 homeopathic preparations (A) 5590 ml T01RS02 homeopathic preparations (C) 584400 g T01RS02 homeopathic preparations (O) 1660 g T01RS02 homeopathic preparations (O) 1339900 pieces

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ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day T01RS02 homeopathic preparations (O) 1932020 ml T01RS02 homeopathic preparations (P) 44 ml T01RS02 homeopathic preparations (R) 12 pieces V VARIOUS 0,1797 V01 ALLERGENS V01A ALLERGENS V01AA Allergen extracts V01AA02 Grass pollen (O) 144 pieces V01AA02 Grass pollen (P) 83 pieces V01AA03 House dust mites (O) 259 pieces V01AA03 House dust mites (P) 36 ml V01AA03 House dust mites (P) 159 pieces V01AA05 Tree pollen (P) 288 pieces V01AA05 Tree pollen (SL) 679 pieces V01AA07 Allergen products (insects) (P) 126 pieces V01AA10 Flowers (O) 8 pieces V01AA11 Animals (O) 18 pieces V01AA80 Tree and grass pollen (O) 72 pieces V01AA80 Tree and grass pollen (P) 37 pieces V01AA83 Grass pollen+ Flowers (O) 18 pieces V01AA84 Tree and flower pollen (O) 30 pieces V03 ALL OTHER THERAPEUTIC PRODUCTS 0,1797 V03A ALL OTHER THERAPEUTIC PRODUCTS 0,1797 V03AB V03AB14 (P) 272,5 g V03AB15 Naloxone (P) 4,932 g V03AB16 (P) 15600 ml V03AB17 Methylthioninium chloride (P) 150,5 g V03AB25 (P) 0,22 g V03AB33 Hydroxocobalamin (P) 5 g V03AB34 (P) 1 g V03AB35 (P) 28 g V03AB37 Idarucizumab (P) 10 g V03AC Iron chelating agents V03AC02 Deferiprone (O) 150 g V03AC03 (O) 7010,8 g V03AE Drugs for treatment of hyperkalemia and hyperphosphatemia 0,1099 V03AE01 Polystyrene sulfonate (O, R) 1308196,5 g 45 g 0,0604 V03AE02 Sevelamer (O) 98064 g 6,4 g 0,0319 V03AE03 Lanthan (O) 19035 g 2,25 g 0,0176 V03AF Detoxifying agents for antineoplastic treatment 0,0698 V03AF01 Mesna (P) 4968 g V03AF03 Calcium folinate (O) 20,55 g 0,06 g 0,0007 V03AF07 Rasburicase (P) 0,594 g 0,014 g 0,0001 V03AF10 Sodium levofolinate (P) 996,4 g 0,03 g 0,069 V03AH Drugs for treatment of V03AH01 (O) 10 g V03AN Medical gases V03AN01 Oxygen (I) 440437500 ml V03AN05 Air, medicinal (I) 1800000 ml V03AX Other therapeutic products V03AX01 Yohimbic acid (O) 0,25 g V04 DIAGNOSTIC AGENTS V04C OTHER DIAGNOSTIC AGENTS V04CD Tests for pituitary function V04CD04 Corticorelin (P) 0,0008 g V04CF Tuberculosis diagnostics V04CF01 Tuberculin (P) 606450 U

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ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day V04CJ Tests for thyreoidea function V04CJ02 Protirelin (P) 0,002 g V04CX Other diagnostic agents V04CX80 Patent blue V (P) 3,25 g V04CX81 chloride (I) 43,368 g V04CX82 Hexaminolevulinate (P) 25,245 g V04CX83 Indocyanine green (P) 2,625 g V04CX87 Carbon monoxide+ Helium (I) 40000 ml V04CX88 Mannitol (I) 420 pieces V07 ALL OTHER NON-THERAPEUTIC PRODUCTS V07A ALL OTHER NON-THERAPEUTIC PRODUCTS V07AB Solvents and diluting agents, incl. irrigating solutions V07AB80 Sodium chloride (P) 6655200 ml V07AB83 Water for injection (NA) 9799200 ml V07AY Other non-therapeutic auxiliary products V07AY80 doonororgani säilituslahus (NA) 67200 ml V08 CONTRAST MEDIA V08A X-RAY CONTRAST MEDIA, IODINATED V08AA Watersoluble, nephrotropic, high osmolar X-ray contrast media V08AA01 Sodium amidotrizoate+ Meglumine Amidotrizoate (P) 5600 ml V08AB Watersoluble, nephrotropic, low osmolar X-ray contrast media V08AB02 Iohexol (P) 1642961 g V08AB04 Iopamidol (P) 158655,2 g V08AB05 Iopromide (P) 875272,5 g V08AB09 Iodixanol (P) 2589070 g V08AD Non-watersoluble X-ray contrast media V08AD01 Ethyl esters of iodised fatty acids (P) 96 g V08B X-RAY CONTRAST MEDIA, NON-IODINATED V08BA Barium sulfate containing X-ray contrast media V08BA01 Barium sulfate (O) 216900 g V08BA01 Barium sulfate (O, R) 40000 g V08C MAGNETIC RESONANCE IMAGING CONTRAST MEDIA V08CA Paramagnetic contrast media V08CA01 Gadopentetic acid (P) 3520 ml V08CA02 Gadoteric acid (P) 2450 ml V08CA03 Gadodiamide (P) 39500 ml V08CA09 Gadobutrol (P) 61987,5 ml V08CA10 Gadoxetic acid (P) 3520 ml V08D ULTRASOUND CONTRAST MEDIA V08DA Ultrasound contrast media V08DA05 Sulphur hexafluoride (P) 200 ml

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