Isolation and Characterization of Neuroprotective Components from Citrus Peel and Their Application As Functional Food
←確認用doi (左上Y座標:-17.647 pt) 2 Chem. Pharm. Bull. 69, 2–10 (2021) Vol. 69, No. 1 Current Topics Pharmaceutical Research for Quality Evaluation and Characterization of Foods and Natural Products Review Isolation and Characterization of Neuroprotective Components from Citrus Peel and Their Application as Functional Food Yoshiko Fur ukawa,*,a Satoshi Okuyama,a Yoshiaki Amakura,b Atsushi Sawamoto,a Mitsunari Nakajima,a Morio Yoshimura,b Michiya Igase,c Naohiro Fukuda,d Takahisa Tamai,d and Takashi Yoshidab,e a Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University; 4–2 Bunkyo-cho, Matsuyama, Ehime 790–8578, Japan: b Department of Pharmacognosy, College of Pharmaceutical Sciences, Matsuyama University; 4–2 Bunkyo-cho, Matsuyama, Ehime 790–8578, Japan: c Department of Geriatric Medicine and Neurology, Ehime University Graduate School of Medicine; 454 Shizugawa, To-on, Ehime 791–0295, Japan: d Ehime Institute of Industrial Technology; 487–2 Kumekubota, Matsuyama, Ehime 791–1101, Japan: and e Department of Pharmaceutical Sciences, Okayama University; Okayama 701–1152, Japan. Received March 22, 2020 The elderly experience numerous physiological alterations. In the brain, aging causes degeneration or loss of distinct populations of neurons, resulting in declining cognitive function, locomotor capability, etc. The pathogenic factors of such neurodegeneration are oxidative stress, mitochondrial dysfunction, inflamma- tion, reduced energy homeostatis, decreased levels of neurotrophic factor, etc. On the other hand, numerous studies have investigated various biologically active substances in fruit and vegetables. We focused on the peel of citrus fruit to search for neuroprotective components and found that: 1) 3,5,6,7,8,3,4-heptamethoxy- flavone (HMF) and auraptene (AUR) in the peel of Kawachi Bankan (Citrus kawachiensis) exert neuroprotec- tive effects; 2) both HMF and AUR can pass through the blood–brain barrier, suggesting that they act di- rectly in the brain; 3) the content of AUR in the peel of K.
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