Aarskog Syndrome, 1029 Aase-Smith Syndrome, 1029 Aase Syndrome

Total Page:16

File Type:pdf, Size:1020Kb

Aarskog Syndrome, 1029 Aase-Smith Syndrome, 1029 Aase Syndrome Index A Adam complex, 732-733 lambda pattem, 233 Aarskog syndrome, 1029 Adduction, 125 V-pattern, 232 Aase-Smith syndrome, 1029 Adhesive syndrome, 255 X-pattern, 233 Aase syndrome, 1029 Adie's tonic pupil, 1013 Y-pattem, 232 Abduction, 125 Adjustable suture techniques, 279 Alport's syndrome, 451, 464, 665, Abetalipoproteinemia, 101, 1029 Adolescent chlamydial 824-826 Ablepharon-macrostomia syndrome, conjunctivitis, 339 Alstrom syndrome, 103, 548, 661, 1029 Adrenochrome, 363 826-827 Abnormal visual development, 158 Adrenoleukodystrophy, 977-978 Altematecover testing, 195 Abruzzo-Erickson syndrome, 1029 neonatal, 977 Alternates fixation, 164 Acanthamoeba, 399, 400 Afferent pupillary defect, 867-868 Amaurosis, Leber's, 546-547 keratitis, 399-400 Afterimage test, 185-186 Amblyopia, 123-296 Acanthocytosis, 1022 Aglossia-adactyly syndrome, 1048 assessment, 190 Accommodative convergence, 155, Agnathia-holoprosencephaly, 33 associated with cataract, 471 225 Agonist, 125 classification of, 160 to accommodation ratio, Agyria, 941 with congenital-infantile esotropia, measuring, 198-199 Aicardi's syndrome, 720, 823-824, 206 near reflex, 155 931, 932-933 diagnosis, 163-166 Accommodative esotropia, 213-214 AIDS fixation testing for, 164-166 infantile, 218-219 ocular manifestations of, 514-515 functional, 159 Achiasmia, 111 opportunistic ocular infections, hypermetropic, bilateral, 162 Achromatopsia, 103, 1016 635-636 organic, 159 Acid bum, 77 Airbag trauma, 88 pathophysiology, 160 Acid solutions, 86 Alacrima, 314, 348 prognosis, 170 Acrocallosal syndrome, Schinzel congenital, 348 prognosis of, 170 type, 1029 Alagille's syndrome, 371 strabismis, 160-161 Acrocephalopolydactylous dysplasia, Albers-Schonberg disease, 758-759 treatment, 167-170 1029 Albinism, 1ll-112, 749-750, unilateral pattem distortion, Acrocephalopolysyndactyly, 1032, 1016-1017 161-162 1040 Albright's syndrome, 329 vision screening, 166-167 Acrocephaloysyndactyly, 1049, 1051 Alignment, neonatal, 157-158 visual evoked potentials, 113-115 Acrodysostosis, 10029 eye movement development, 158 Amblyopia ex anopsia, 159 Acrofacial dysostosis, 1047 smooth pursuit asymmetry, 158 Amblyopic vision, 163 Acrofacial dysplasia, 1039 Alkahne bum, 77 Amblyoscope, 184-185 Acro-fronto-facio-nasal dysostosis Alkahne solutions, 85 Amblys, 159 syndrome, 1029 Alkaptonuria, 406, 750 American Cancer Society, 75 Acromegaloid facial appearance Allagille syndrome, 664 American Foundation for Blind, 76 syndrome, 1029 Allergie conjunctivitis, 343-346 American Printing House for Blind, Acromegaloid phenotype-cutis atopic jeratoconjunctivitis, 76 verticis gyrata-comeal 345-346 Ametropie amblyopia, 162 leukoma, 1029 giant papillary conjunctivitis, 345 Amniocele, 315 Acro-osteolysis syndrome, 1040 seasonal allergic conjunctivitis, Amniotic band syndrome, 300, Active forced-generation test, 202 343-344 732-733 Active stimulation, amblyopia, 170 vemal conjunctivitis, 344-345 Amniotic rupture sequence, 732-733 Acuity Allergie granulomatosis, 572 Amniotocele, 315-316, 338 binocular, 965 Allgrove syndrome, 352 Amplification, electroretinogram, 94 neuro-ophthalmology exam, Alopecia, 639 Amyloid, 407 865-866 Alphabet pattems, 232-249 lid, 310 testing, low-illumination, 866-867 A-pattem, 232-234, 232-248, 233 Amyloidosis, 407 Acute retinal necrosis syndrome, 510 arrow pattem, 232 Anemia, 573 1059 1060 INDEX Anencephaly, 33-34, 1022 embryology, 369-3 70 Atopic keratoconjunctivitis, 345 Anesthesia, examination under, 60 iris ectropion, 3 7 4 Atrophy Aneuploidy, 678, 694 iris hypoplasia, 371 dominant optic, 109 Angelman syndrome, 1036 mesenchymal dysgenesis, 369 gyrate, 101, 664 Angioedema, lid, 310 posterior embryotoxon, 370-371 hemifacial, 991-993 Angioid streaks, 566, 660-661, 740 primary congenital glaucoma, 375 hereditary optic, 109 Angio-Osteohypertrophy syndrome, Rieger's anomaly, 372 iris, 376 1043 Anterior segment disease, 333-480 Atropine mydriasis, 1013-1014 Angiotensin-converting enzyme, 630 Anterior subcapsular cataract, Atropine penalization, 169 Angle kappa, testing, 192-193 451-452 ATR-X-syndrome, 1057 Angle of anomaly, 176, 185 Antiepileptic medication, 110 Autoimmune myasthenia gravis, Angle recession, 84-85 Antisaccades, 876 898-901 Angular conjunctivitis, 339 Antisuppression, 178 botulism, 901 Aniridia, 434-436, 493-494, 659 A-pattems, 232-248, 283 Autorefractors, 66 Aniridia-cerbellar ataxia-mental Apert syndrome, 714-715 Autosomal dominant keratitis, 394 deficiency, 1039 Aphakia, 469-4 72 Autosomal dominant neovascular Aniseikonia, 172 Aphakic glaucoma, 495-496 inflammatory Anisocoria, 868-869, 1011-1015 Aphakic spectacles, 4 71 vitreoretinopathy, 563-564 Adie's tonic pupil, 1013 Aplasia, 661 Autosomal dominant retinitis atropine mydriasis, 1013-1014 extraocular muscles, 2 70 pigmentosa, 545 causes of, 1012 Aplasia cutis congenita, 1022 Autosomal dominant neuroanatomy, 1011 Arachnodactyly, 741, 1022 vitreoretinochoroidopathy, parasympathetic lesions, 1013 Arachnoid cysts, 952 563-564 simple ansiocoria, 1012 Arden ratio, 529 Autosomal recessive retinitis sympathetic lesions, 1012-1013 Argyria, 1022 pigmentosa, 545-546 third nerve palsy, 1013 Argyrosis, 363 Avellino dystrophy, 412 Anisometropia, retinopathy of Arhinencephaly, 1022 Avitaminosis A, 401 prematurity, 611-612 Arnold-Chiari malformation, Axenfeld anomaly, 433 Anisametropie amblyopia, 162 993-995 Axenfeld-Rieger anomaly, 1031 Ankyloblepharon, 303 Arrow pattem, 232 Axenfeld-Rieger syndrome, 371-373, Anomalaus head posturing, 967 Arthritis 433, 434 Anomalaus retinal correspondence, juvenile chronic, 501-503 Axenfeld's anomaly, 372, 494 163, 175-177 juvenile idiopathic, 501-503 Axenfeld's syndrome, 494 Anophthalmia, 386-387 juvenile rheumatoid, 501-503, Axes of Fick, 140 Anophthalmos, 383, 386 631-632 Axiallength, 39 Antagonist, 125 Arthrogryposis, 1022 Anterior blepharitis, 346 Arthro-ophthalmopathy, hereditary B Anterior cataract, 450-452 progressive, 557, 746, 1053 Bacillus, 516 Anterior chamber, 17-18 Arylsulfatase-A, 974 Bacterial conjunctivitis, 338-340 Anterior chamber angle, 43-44 Aspartoacylase deficiency, 982 adolescent chlamydial development of, 43-44 Aspergillus, 403, 516 conjunctivitis, 339 Anterior chamber washout, 82 Asphyxia, 944 angular conjunctivitis, 339 Anterior membrane dystrophy, 410 Asphyxiating thoracic dysplasia, 666 haemophilus influenzae, 339 Anterior polar cataract, 450-451 Asphyxiating thoracic dystrophy, Parinaud's oculoglandular Anterior pyramidal cataract, 451 1042 syndrome, 339-340 Anterior scleritis, diffuse, 515 Association for Macular Diseases, 76 Bacterial diseases, 845-849 Anterior segment Association for Retarded Citizens of cat scratch disease, 845-846 dysgenesis, 29-30, 378 u.s., 76 Lyme disease, 846-847 trauma, nonperforating, 84-85 Astigmatism, retinopathy of syphilis, 847-849 vascular supply, 138-139 prematurity, 611-612 Bacterial keratitis, 339, 399, 402 Anterior segment developmental Astrocytic hamartoma, 581 Bacterial meningitis, 945 anomalies, 369-375 Astrocytoma, 946 Bagolini lenses, 183 4q25, 373-374 of brainstem, 947 Bagolini striated lens test, 17 4 6p25, 373 of cerebellum, 947 Baller-Gerold syndrome, 1031 13q14, 373 of cerebrum, 94 7 Band keratopathy, 407 acquired ectropion, 3 7 4 of hypothalamus, 947 Bannayan-Riley-Ruvalcaba Alagille's syndrome, 371 of optic nerve, 947 syndrome, 1031 Axenfeld-Rieger syndrome, Ataxia syndromes, hereditary, Bannayan syndrome, 1031 371-373 984-985 Bardet-Biedl syndrome, 101, 548, Axenfeld's anomaly, 372 Ataxia telangiectasia, 777-778, 985, 662, 666, 1031 congenital iris ectropion, 374-375 1031 Barkan's membrane, 487 comea, 391 Atopic jeratoconjunctivitis, 345-346 Bartonella henselae, 340, 845, 846 INDEX 1061 Bartonella henselae, 845, 846 Blepharitis, 346-347 tumors, 946-952 Basal encephalocele, 924 anterior, 346 of congenital origin, 951-952 Basilar impression syndromes, 993, anterior blepharitis, 346-347 of glial origin, 946-950 997-999 extemal hordeolum, 34 7 of meningeal origin, 950-951 Bassen-Komzweig disease, 1029 phlyctenular keratoconjunctivitis, of neural origin, 950 Bathocephaly, 1022 347 Branchio-oculo-facial syndrome, 828, Batten-Mayou disease, 975 posterior, 346 1032 Batten's disease, 105, 112, 975-976, staphylococcal blepharitis, Branchio-oto-renal syndrome, 314, 1016 346-347 1045 Battered child syndrome, 77-79 Blepharoconjunctivitis, 346 Brown's syndrome, 242, 245-248, Beals' syndrome, 1031 seborrheic, 347-348 902 Bear tracks, 577, 578, 582 Blepharophimosis, 302, 1032 acquired, 245-246 Beckwith-Wiedemann syndrome, familial, 1032 canine tooth syndrome, 248 1031 Blepharoptosis, 303 clinical features, 245 Behcet's disease, 512-513 Blindness. See also Night blindness; congenital, 245, 902 Beibomian gland dysfunction, 348 Visualloss elevation deficit, 246-247 Berardinelli-Lipodystrophy color, 550-551 surgery, 247-248 syndrome, 1032 parental reactions to diagnosis of, etiology, 245 Berardinelli-Seip Congenital 72-73 iatrogenic, 240 Lipodystrophy syndrome, 1032 Bloch-Sulzherger syndrome, 752, inflammatory, 246 Bergmeister's papilla, formation of, 21 1042 silicone tendon expander, 247-248 Berlin's edema. See Commotio Blood staining, comeal, 80 Wright superior oblique tendon retinae Blue-dot cataract, 457 expander, 24 7 Berman's syndrome, 1052 Blue nevi, 365 Bruch's membrane, 523-538 Bemheimer-Seiteberger disease, 1039 Blue sclera, 387, 745 Bruckner reflex test, 64, 193 Best's disease, 103, 528-530 Blurred disc margins, 1010-1011 Brushfield spots, 437, 683 Best's vitelliform dystrophy, 528 Blurred retinal image, bilateral, Bulineck anomalies, 993
Recommended publications
  • Dermatology Eponyms – Sign –Lexicon (P)
    2XU'HUPDWRORJ\2QOLQH Historical Article Dermatology Eponyms – sign –Lexicon (P)� Part 2 Piotr Brzezin´ ski1,2, Masaru Tanaka3, Husein Husein-ElAhmed4, Marco Castori5, Fatou Barro/Traoré6, Satish Kashiram Punshi7, Anca Chiriac8,9 1Department of Dermatology, 6th Military Support Unit, Ustka, Poland, 2Institute of Biology and Environmental Protection, Department of Cosmetology, Pomeranian Academy, Slupsk, Poland, 3Department of Dermatology, Tokyo Women’s Medical University Medical Center East, Tokyo, Japan, 4Department of Dermatology, San Cecilio University Hospital, Granada, Spain, 5Medical Genetics, Department of Experimental Medicine, Sapienza - University of Rome, San Camillo-Forlanini Hospital, Rome, Italy, 6Department of Dermatology-Venerology, Yalgado Ouédraogo Teaching Hospital Center (CHU-YO), Ouagadougou, Burkina Faso, 7Consultant in Skin Dieseases, VD, Leprosy & Leucoderma, Rajkamal Chowk, Amravati – 444 601, India, 8Department of Dermatology, Nicolina Medical Center, Iasi, Romania, 9Department of Dermato-Physiology, Apollonia University Iasi, Strada Muzicii nr 2, Iasi-700399, Romania Corresponding author: Piotr Brzezin′ski, MD PhD, E-mail: [email protected] ABSTRACT Eponyms are used almost daily in the clinical practice of dermatology. And yet, information about the person behind the eponyms is difficult to find. Indeed, who is? What is this person’s nationality? Is this person alive or dead? How can one find the paper in which this person first described the disease? Eponyms are used to describe not only disease, but also clinical signs, surgical procedures, staining techniques, pharmacological formulations, and even pieces of equipment. In this article we present the symptoms starting with (P) and other. The symptoms and their synonyms, and those who have described this symptom or phenomenon. Key words: Eponyms; Skin diseases; Sign; Phenomenon Port-Light Nose sign or tylosis palmoplantaris is widely related with the onset of squamous cell carcinoma of the esophagus.
    [Show full text]
  • Differentiate Red Eye Disorders
    Introduction DIFFERENTIATE RED EYE DISORDERS • Needs immediate treatment • Needs treatment within a few days • Does not require treatment Introduction SUBJECTIVE EYE COMPLAINTS • Decreased vision • Pain • Redness Characterize the complaint through history and exam. Introduction TYPES OF RED EYE DISORDERS • Mechanical trauma • Chemical trauma • Inflammation/infection Introduction ETIOLOGIES OF RED EYE 1. Chemical injury 2. Angle-closure glaucoma 3. Ocular foreign body 4. Corneal abrasion 5. Uveitis 6. Conjunctivitis 7. Ocular surface disease 8. Subconjunctival hemorrhage Evaluation RED EYE: POSSIBLE CAUSES • Trauma • Chemicals • Infection • Allergy • Systemic conditions Evaluation RED EYE: CAUSE AND EFFECT Symptom Cause Itching Allergy Burning Lid disorders, dry eye Foreign body sensation Foreign body, corneal abrasion Localized lid tenderness Hordeolum, chalazion Evaluation RED EYE: CAUSE AND EFFECT (Continued) Symptom Cause Deep, intense pain Corneal abrasions, scleritis, iritis, acute glaucoma, sinusitis, etc. Photophobia Corneal abrasions, iritis, acute glaucoma Halo vision Corneal edema (acute glaucoma, uveitis) Evaluation Equipment needed to evaluate red eye Evaluation Refer red eye with vision loss to ophthalmologist for evaluation Evaluation RED EYE DISORDERS: AN ANATOMIC APPROACH • Face • Adnexa – Orbital area – Lids – Ocular movements • Globe – Conjunctiva, sclera – Anterior chamber (using slit lamp if possible) – Intraocular pressure Disorders of the Ocular Adnexa Disorders of the Ocular Adnexa Hordeolum Disorders of the Ocular
    [Show full text]
  • Guide to Policy & Practice Questions
    OREGON BOARD OF CHIROPRACTIC EXAMINERS GUIDE TO POLICY & PRACTICE QUESTIONS 530 Center St NE, suite 620 Salem, OR 97301 (503) 378-5816 [email protected] Updated/Adopted: 9/17/2020 TABLE OF CONTENTS SECTION I ............................................................................................................................................................................................... 6 DEVICES, PROCEDURES, AND SUBSTANCES ............................................................................................................................... 6 DEVICES ................................................................................................................................................................ 6 BAX 3000 AND SIMILAR DEVICES................................................................................................................................................ 6 BIOPTRON LIGHT THERAPY ........................................................................................................................................................ 6 CPAP MACHINE, ORDERING ....................................................................................................................................................... 6 CTD MARK I MULTI-TORSION TRACTION DEVICE................................................................................................................... 6 DYNATRON 2000 ...........................................................................................................................................................................
    [Show full text]
  • Clinicopathological Correlation of Acquired Hyperpigmentary Disorders
    Symposium Clinicopathological correlation of acquired Dermatopathology hyperpigmentary disorders Anisha B. Patel, Raj Kubba1, Asha Kubba1 Department of Dermatology, ABSTRACT Oregon Health Sciences University, Portland, Oregon, Acquired pigmentary disorders are group of heterogenous entities that share single, most USA, 1Delhi Dermatology Group, Delhi Dermpath significant, clinical feature, that is, dyspigmentation. Asians and Indians, in particular, are mostly Laboratory, New Delhi, India affected. Although the classic morphologies and common treatment options of these conditions have been reviewed in the global dermatology literature, the value of histpathological evaluation Address for correspondence: has not been thoroughly explored. The importance of accurate diagnosis is emphasized here as Dr. Asha Kubba, the underlying diseases have varying etiologies that need to be addressed in order to effectively 10, Aradhana Enclave, treat the dyspigmentation. In this review, we describe and discuss the utility of histology in the R.K. Puram, Sector‑13, diagnostic work of hyperpigmentary disorders, and how, in many cases, it can lead to targeted New Delhi ‑ 110 066, India. E‑mail: and more effective therapy. We focus on the most common acquired pigmentary disorders [email protected] seen in Indian patients as well as a few uncommon diseases with distinctive histological traits. Facial melanoses, including mimickers of melasma, are thoroughly explored. These diseases include lichen planus pigmentosus, discoid lupus erythematosus, drug‑induced melanoses, hyperpigmentation due to exogenous substances, acanthosis nigricans, and macular amyloidosis. Key words: Facial melanoses, histology of hyperpigmentary disorders and melasma, pigmentary disorders INTRODUCTION focus on the most common acquired hyperpigmentary disorders seen in Indian patients as well as a few Acquired pigmentary disorders are found all over the uncommon diseases with distinctive histological traits.
    [Show full text]
  • A Description of the Clinical Features of Brimonidine- Associated Uveitis Alyssa Louie Primary Care Resident, San Francisco VA
    Drug-induced intraocular inflammation: A description of the clinical features of brimonidine- associated uveitis Alyssa Louie Primary Care Resident, San Francisco VA Abstract: A description of the clinical features, diagnostic work-up, and management of acute anterior uveitis caused by brimonidine, a widely used glaucoma medication. I. Case History a. Patient demographics: 74 year-old white male b. Chief complaint: eye pain, redness, irritation for last 2 weeks c. Ocular and medical history: i. Ocular history 1. Primary open angle glaucoma OU, diagnosed 8 years ago 2. Senile cataracts OU, not visually significant 3. Type 2 Diabetes without retinopathy OU 4. No prior history of uveitis ii. Medical history: Diabetes Mellitus Type 2 iii. No known drug allergies d. Medications i. Ocular: dorzolamide BID OU (1.5 years), brimonidine BID OU (11 months), travatan QHS OU (5.5 years) ii. Medical: metformin 500mg tab BID PO II. Pertinent Findings a. Clinical exam i. Visual acuities: OD 20/20-, OS 20/20- ii. Goldmann applanation tonometry: 13 mm Hg OD, 13 mm Hg OS iii. Anterior segment 1. OU: 3+ diffuse conjunctival injection 2. OU: central and inferior granulomatous keratic precipitates 3. OU: Grade 1+ cell, 1+ flare 4. OU: No synechiae or iris changes were present iv. Posterior segment 1. Optic Nerve a. OD: Cup-to-disc ratio 0.70H/V, distinct margins b. OS: Cup-to-disc ratio 0.75H/V, distinct margins 2. Posterior pole, periphery, vitreous: unremarkable OU b. Laboratory Studies i. ACE, Lysozyme, FTA-ABS, VDRL, HLA-B27, Rheumatoid Factor, ANA, PPD, Chest X- ray: all negative/unreactive III.
    [Show full text]
  • Q-Switched Laser-Induced Chrysiasis Treated with Long-Pulsed Laser
    THE CUTTING EDGE SECTION EDITOR: GEORGE J. HRUZA, MD; ASSISTANT SECTION EDITORS: DEE ANNA GLASER, MD; ELAINE SIEGFRIED, MD Q-Switched Laser-Induced Chrysiasis Treated With Long-Pulsed Laser Patricia Lee Yun, MD; Kenneth A. Arndt, MD; R. Rox Anderson, MD; Wellman Laboratories of Photomedicine, Massachusetts General Hospital, Boston (Drs Yun and Anderson), Skin Care Physicians of Chestnut Hill, Chestnut Hill, Mass (Dr Arndt) The Cutting Edge: Challenges in Medical and Surgical Therapeutics REPORT OF A CASE on her cheeks and forehead ranging from 2 to 6 mm (Figure 1). The lesions did not enhance on Wood’s light A 70-year-old woman presented for elective treatment of examination, suggesting dermal pigmentation. In some lentigines on her face. This was her first treatment with areas, portions of the original lentigo were still visible in any laser. She was treated with a Q-switched alexan- the center of the blue macule. There was no discolora- drite laser (755 nm, 50 nanoseconds, 3.5 J/cm2, 15 pulses tion of the sclera, nails, or hair. A subtle blue-gray hue of 4-mm spot diameter; Candela, Wayland, Mass), caus- in the patient’s general skin color was noted at the time ing what appeared to be usual purpura immediately fol- of reexamination. lowing laser exposure of 8 tan macules. Several weeks A punch biopsy specimen of a representative area dem- later, blue-black discoloration was present, and was at- onstrated numerous black particles within macrophages tributed to postinflammatory hyperpigmentation, but in the dermis. A diagnosis of Q-switched laser-induced failed to lighten over the next 4 months.
    [Show full text]
  • Genes in Eyecare Geneseyedoc 3 W.M
    Genes in Eyecare geneseyedoc 3 W.M. Lyle and T.D. Williams 15 Mar 04 This information has been gathered from several sources; however, the principal source is V. A. McKusick’s Mendelian Inheritance in Man on CD-ROM. Baltimore, Johns Hopkins University Press, 1998. Other sources include McKusick’s, Mendelian Inheritance in Man. Catalogs of Human Genes and Genetic Disorders. Baltimore. Johns Hopkins University Press 1998 (12th edition). http://www.ncbi.nlm.nih.gov/Omim See also S.P.Daiger, L.S. Sullivan, and B.J.F. Rossiter Ret Net http://www.sph.uth.tmc.edu/Retnet disease.htm/. Also E.I. Traboulsi’s, Genetic Diseases of the Eye, New York, Oxford University Press, 1998. And Genetics in Primary Eyecare and Clinical Medicine by M.R. Seashore and R.S.Wappner, Appleton and Lange 1996. M. Ridley’s book Genome published in 2000 by Perennial provides additional information. Ridley estimates that we have 60,000 to 80,000 genes. See also R.M. Henig’s book The Monk in the Garden: The Lost and Found Genius of Gregor Mendel, published by Houghton Mifflin in 2001 which tells about the Father of Genetics. The 3rd edition of F. H. Roy’s book Ocular Syndromes and Systemic Diseases published by Lippincott Williams & Wilkins in 2002 facilitates differential diagnosis. Additional information is provided in D. Pavan-Langston’s Manual of Ocular Diagnosis and Therapy (5th edition) published by Lippincott Williams & Wilkins in 2002. M.A. Foote wrote Basic Human Genetics for Medical Writers in the AMWA Journal 2002;17:7-17. A compilation such as this might suggest that one gene = one disease.
    [Show full text]
  • Hydroxychloroquine-Associated Hyperpigmentation Mimicking Elder Abuse
    Dermatol Ther (Heidelb) (2013) 3:203–210 DOI 10.1007/s13555-013-0032-z CASE REPORT Hydroxychloroquine-Associated Hyperpigmentation Mimicking Elder Abuse Philip R. Cohen To view enhanced content go to www.dermtherapy-open.com Received: June 17, 2013 / Published online: August 14, 2013 Ó The Author(s) 2013. This article is published with open access at Springerlink.com ABSTRACT cleared of suspected elder abuse. A skin biopsy of the patient’s dyschromia confirmed the Background: Hydroxychloroquine may result diagnosis of hydroxychloroquine-associated in cutaneous dyschromia. Older individuals hyperpigmentation. who are the victims of elder abuse can present Conclusion: Hyperpigmentation of skin, with bruising and resolving ecchymoses. mucosa, and nails can be observed in patients Purpose: The features of hydroxychloroquine- treated with antimalarials, including associated hyperpigmentation are described, hydroxychloroquine. Elder abuse is a significant the mucosal and skin manifestations of elder and underreported problem in seniors. abuse are reviewed, and the mucocutaneous Cutaneous findings can aid in the discovery of mimickers of elder abuse are summarized. physical abuse, sexual abuse, and self-neglect in Case Report: An elderly woman being treated elderly individuals. However, medication- with hydroxychloroquine for systemic lupus associated effects, systemic conditions, and erythematosus developed drug-associated black accidental external injuries can mimic elder and blue pigmentation of her skin. The abuse. Therefore, a complete medical history dyschromia was misinterpreted by her and appropriate laboratory evaluation, including clinician as elder abuse and Adult Protective skin biopsy, should be conducted when the Services was notified. The family was eventually diagnosis of elder abuse is suspected. Keywords: Abuse; Dyschromia; Elderly; P.
    [Show full text]
  • Multi-Organ Teratogenesis Sequels of Bigger Size Particles Colloidal
    ytology & f C H o is Prakash, et al., J Cytol Histol 2018, 9:2 l t a o n l o r DOI: 10.4172/2157-7099.1000501 g u y o J Journal of Cytology & Histology ISSN: 2157-7099 Research Article Open Access Multi-Organ Teratogenesis Sequels of Bigger Size Particles Colloidal Silver in Primate Vertebrates Pani Jyoti Prakash*1, Singh Royana2 and Pani Sankarsan3 1Department of Anatomy, Faculty of Medicine, Institute of Medical Science and Research, Karjat, Bhivpuri, India 2Department of Anatomy, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttarpradesh, India 3Deapartment of Surgery, Institute of Medical Science and Research, Karjat, Bhivpuri, India *Corresponding author: Prakash PJ, Department of Anatomy, Faculty of Medicine, Institute of Medical Science and Research, Karjat, Bhivpuri, India, Tel: 8433668356; E-mail: [email protected] Received date: February 21, 2018; Accepted date: March 12, 2018; Published date: March 16, 2018 Copyright: © 2018 Prakash PJ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Abstract Back ground: In this most recent, update global arena for consumers products most of the daily applications of bigger silver nano particles (20 to 100 nano meter range) are effected as anti-viral and anti-parasitic agents in clinical medicine and diagnosis which is a positive feedback. However, the major negative feedback of bigger size silver nano particles on human, animal and primate vertebrate body is multisystem teratogenicity focuses. Material and methods: This study was designed to investigate teratogenic effects of bigger size nano silver which is poly vinyl pyrollidone coated and sodium borohydride stabilized.
    [Show full text]
  • Ocular Chrysiasis: a Teaching Case Report | 1
    Ocular Chrysiasis: a Teaching Case Report | 1 Abstract Ocular chrysiasis is a deposition of gold in ocular structures secondary to gold salt therapy, which is primarily used in infectious, rheumatoid and psoriatic arthritis. Gold therapy has become an extremely rare treatment due to the advent of rheumatologic medications with better safety profiles. However, any patient who has undergone gold therapy could potentially have ocular chrysiasis. Therefore, it must be included as a differential in the presence of corneal or lenticular changes in these patients. Additionally, it is important to include ocular chrysiasis as a differential in the presence of crystalline keratopathies. A detailed medical history and thorough ocular examination can assist clinicians in making a correct diagnosis. Key Words: gold salts, ocular chrysiasis, autoimmune disease, cornea Background The following case report is meant to be used as a guide in teaching optometry students and residents. It is relevant to all levels of training. Ocular chrysiasis is a deposition of gold in ocular structures following chrysotherapy, which is the medical use of gold salts. Chrysotherapy was primarily used to treat infectious, rheumatoid and psoriatic arthritis. This therapy has become an extremely rare treatment due to the advent of rheumatologic medications with better safety profiles. Any patient who has undergone gold therapy could potentially have ocular chrysiasis. Therefore, it must be included as a differential in the presence of corneal or lenticular changes in these patients. This case illustrates the importance of history-taking skills, examination and decision-making in effectively diagnosing this condition. Case Description A 54-year-old Caucasian female presented for an annual eye examination.
    [Show full text]
  • Characteristics of Allergy in Autoimmune Thyroid Diseases Ildikó
    Characteristics of allergy in autoimmune thyroid diseases Ildikó Molnár MD, PhD, EndoMed, Hungary ImmunSum, Baltimore, 2014 Relationship between allergic responses and thyroid autoimmunity IgE levels IgE deposits are present in Graves’ thyroid and orbital tissues (Werner SC et al., N Engl Med, 1972;287:421-425.; Raikow RB et al., Ophthalmol. 1990; 97:629-635.) Elevated IgE levels associated with hyperthyroid Graves’ disease (Akira S et al., J Clin Endocrinol Metab 1999; 84:3602-3605.; Takashi Y et al., J Clin Endocrinol Metab 2000; 85:2775- 2778.) Evidence of immunglobulin E autoantibodies to thyrotropin receptor (TSH rec) and thyroid peroxidase (TPO) (Metcalfe R et al., J Clin Endocrinol Metab 2002;87:1754-1761.; Gou J et al., Clin Immunol Immunopathol 1997; 82: 157-162.) Th2-derived cytokine profils Elevated serum levels of IL-5 and IL-13 cytokines. (Hidaka Y et al., Thyroid 1998; 8:235-239.; Ichiro K et al., J Clin Endocrinol Metab 2001; 86:3540-3544.) Allergic rhinitis associated frequently with Graves’ disease (Amino N et al., Thyroid 2003; 13:811-814.; Hidaka Y et al., Thyroid 1996; 6: 349-351.) Common key factors regulate the immune responses in both allergic and autoimmune conditions (Rottem M et al., Dev Immunology 2002; 9: 161-167.) ImmunSum, Baltimore, 2014 Previous results Graves’ ophthalmopathy associated with increased total IgE serum levels. Molnár I et al., Eur J Med Rev 1996; 1:543-546. Hyperthyroid Graves’ ophthalmopathy demonstrated elevated serum IL-5 levels compared to patients who had no eye signs. Molnár I , Abstract: ACT International Suppl., 2000; 2: 220. Decreased serum levels of nerve growth factor (NGF) associated with hyperthyroid Graves’ ophthalmopathy compared to those who had no eye signs.
    [Show full text]
  • Tissue-Engineered Models for Glaucoma Research
    micromachines Review Tissue-Engineered Models for Glaucoma Research Renhao Lu 1 , Paul A. Soden 2 and Esak Lee 1,* 1 Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA; [email protected] 2 College of Human Ecology, Cornell University, Ithaca, NY 14853, USA; [email protected] * Correspondence: [email protected]; Tel.: +1-607-255-8491 Received: 5 June 2020; Accepted: 22 June 2020; Published: 24 June 2020 Abstract: Glaucoma is a group of optic neuropathies characterized by the progressive degeneration of retinal ganglion cells (RGCs). Patients with glaucoma generally experience elevations in intraocular pressure (IOP), followed by RGC death, peripheral vision loss and eventually blindness. However, despite the substantial economic and health-related impact of glaucoma-related morbidity worldwide, the surgical and pharmacological management of glaucoma is still limited to maintaining IOP within a normal range. This is in large part because the underlying molecular and biophysical mechanisms by which glaucomatous changes occur are still unclear. In the present review article, we describe current tissue-engineered models of the intraocular space that aim to advance the state of glaucoma research. Specifically, we critically evaluate and compare both 2D and 3D-culture models of the trabecular meshwork and nerve fiber layer, both of which are key players in glaucoma pathophysiology. Finally, we point out the need for novel organ-on-a-chip models of glaucoma that functionally integrate currently available 3D models of the retina and the trabecular outflow pathway. Keywords: glaucoma; tissue engineering; trabecular meshwork; Schlemm’s canal; retinal ganglion cell; intraocular pressure; optic nerve head; electrospinning; soft lithography; 3D scaffold; 3D bioprinting 1.
    [Show full text]