FALL 2013

Duke Doctors Create First BIOENGINEERED BLOOD VESSELS CONTENTS

Message from the Dean IN BRIEF FEATURES

02 Andrews Honored 22 Creating Medical Leaders with Two Awards This fall, we will welcome reunion classes back to sor in Duke’s Department of Surgery, and his former DukeMed Alumni News 26 Classnotes Duke for Medical Alumni Weekend on October Duke colleague, Laura Niklason, MD, PhD. Fifteen is published two times a year by the Duke Medical Alumni Association. 18-19. This is always one of my favorite weekends. years ago, they began a collaboration to develop a Issues are available online at It’s an opportunity to reminisce with alumni and bioengineered blood vessel. This spring, Dr. Lawson medalumni.duke.edu. Your comments, ideas, and letters also, importantly, to discuss the future of the school grafted a synthetic vessel into an artery in a Duke to the editor are welcome. and academic medicine. This year marks the 45th patient’s arm, the first-in-human procedure of its Please contact us at: Anniversary of the Davison Club, and I want to kind in the United States. DukeMed Alumni News 512 S. Mangum St., Suite 400 extend my heartfelt gratitude to every member. Our Also this spring, a group of Duke University med- Durham, N.C. 27701-3973 alumni are our most loyal supporters – with their e-mail: [email protected] ical students received a national Alpha Omega Duke Medicine Pavilion Opens 07 time, ideas, feedback, and contributions. While it Alpha Service Leadership Project Award recogniz- Editor Marty Fisher 02 School of Medicine is said often, it has never been more true that the ing innovative programs that support leadership Top Ranked support we receive from Assistant Editor development for medical students through men- Jim Rogalski our alumni and friends is 03 Celebration Honors toring, observation, and science learning. Duke Contributing Writers absolutely critical for the the Legacy of How Petite Belle Hammond students received the award for developing the Bernadette Gillis, Dave Hart, 26 school’s continued success. Duke Leadership and Education (LEAD) Program, Angela Spivey African Americans Got Her Name In this issue, you will get a one of the country’s first formal medical student Art Director David Pickel 28 The Surgeon and the Pilot glimpse of our exceptional leadership curricula. The program was piloted at 04 Students Earn Photography Schweitzer Fellowships students, groundbreaking Duke last year and has been incorporated into the Duke Photography research, and outstanding 2013-2014 curriculum. Brian Baer, Thomas Cordy, Chris Hildreth, Raymond Jones, Outstanding Teachers patient care. You’ll read As you know, there is never a shortage of exciting Jared Lazarus, Rick Olivier, Win Golden Apple about the launch of the David Pickel, David Seaver, achievements and opportunities at Duke, and this Todd Sumlin, Les Todd, Duke Institute for Molecu- year has been no exception. I hope that we will see Jimmy Wallace lar Physiology, an exciting you on campus in the coming months, and I wish Produced by new partnership between you a wonderful fall and holiday season. Duke Medicine Development the Sarah W. Stedman and Alumni Affairs. Sincerely, Copyright Duke University, 2013 Nutrition and Metabolism DMDAA 1389 Center, the Duke Center Cells are “fed” with a special amino acid solution within a If you no longer wish Duke Medicine 31 At Home in the Hospital 2. for Human Genomics, and to contact you regarding fund raising the laboratories of Duke researchers Bill Kraus, MD, or giving opportunities, you may opt and on the Farm bioreactor. The human cells grow and establish themselves in the out by contacting us by mail, phone and Virginia Kraus, MD, PhD. The new institute, or e-mail. That contact information is 33 House Staff Notes scaffolding. The scaffolding biodegrades over a few weeks while led by Chris Newgard, PhD, will host sophisticat- listed below: the cells produce extracellar matrix proteins, primarily collagen. ed capabilities to explore and model human and Nancy C. Andrews, MD, PhD Office of Associate Vice President 35 Obituaries Development and Alumni Affairs 05 Top Students Honored animal physiology, with the goal of understanding Dean, Duke University School of Medicine 512 S. Mangum Street, Suite 400 The solution is pulsed into a sealed sterile plastic bag. Takes up to Vice Chancellor, Academic Affairs Durham, NC 27701 many of the major chronic diseases that impact our 08 $20 Million Gift to Nanaline H. Duke Professor of Medicine e-mail: [email protected] 2 months. world today. phone: 1-800-688-1867 Duke Medicine 16 Professor, Pediatrics A New Institute Looks for Answers to Human Disease In this issue, you’ll also learn about the transforma- Professor, Pharmacology and Cancer Biology Spotlight event to Feature tive research of Jeffrey Lawson, MD, PhD, a profes- CNN’s Sanjay Gupta, MD

Victor J. Dzau, MD Edward G. Buckley, MD Scott Gibson, MBA Sally Kornbluth, PhD Judy Seidenstein Chancellor for Health Affairs, Vice Dean for Education Executive Vice Dean for Vice Dean for Basic Science, Chief Diversity Officer Duke University Duke University School of Medicine Administration, Duke University School of Medicine Duke University School of Medicine President and Chief Executive Officer, Duke University School of Medicine Duke University Health System Theodore N. Pappas, MD Mark Stacy, MD Billy Newton Vice Dean for Medical Affairs, Ann Brown, MD, MHS Vice Dean for Clinical Research, Vice Dean for Finance and The Journey Nancy C. Andrews, MD, PhD Duke University School of Medicine Vice Dean for Faculty Development, Duke University School of Medicine Resource Planning 10 Dean, Duke University School Duke University School of Medicine Duke University School of Medicine to a Bioengineered of Medicine Jill Boy Blood Vessel Vice Chancellor for Academic Affairs, Director of Communications Iain Sanderson, MB, CHB Duke University Duke University School of Medicine Chief Research and Academic Information Officer Duke University School of Medicine

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Andrews Honored Students Launch Duke Wins with Two Awards Peer-Reviewed Federal Funds Dean Nancy Andrews has received two recent Science Journal to Develop awards—the 2013 Marion Spencer Fay Award of Drexel University College of Medicine’s Institute for Women’s Duke medical, graduate, and undergraduate students now have a Diverse Health and Leadership and the 2013 Henry M. Stratton peer-reviewed journal specifically for them to publish articles on Medal of the American Society of Hematology. scientific subjects. The 48-page Duke Science Review (DSR) premiered Scientists in June after its editorial board secured funding from various Duke The Marion Spencer Fay Award, now in its 50th year, Duke University is launching a academic departments. is presented annually to a woman physician and/or program to promote diversity scientist who has made an exceptionally significant Articles are reviewed by the DSR editorial and develop scientific talent in contribution to health care as a practitioner, medical board, which currently consists of 10 Duke undergraduates and graduate educator, administrator and/or research scientist, and medical students and one undergraduate students. The Biosciences Collab- who exhibits significant future potential. student. orative for Research Engagement (BioCoRE) is supported by a $1.8 The journal currently is being published once Dean Andrews is being honored for her research in the million, five-year grant from the a year, but Lowell Nicholson, MSII, an editor study of iron metabolism; her contributions at the local, National Institute of General national, and international level in clinical medicine, for the magazine, said he hopes to expand to

Medical Sciences (NIGMS). JIM WALLACE education, training, research, and community service; more issues as funding becomes available. “There’s always a need to Faces of Change event steering committee co-chair, Loren Robinson, MD’09, (second from left) and her impressive leadership credentials. The editor-in-chief is second-year medical cultivate scientists to the best was among the hundreds who gathered in April to commemorate the individuals who left a lasting student Anirudh Penumaka. The inaugural The Henry M. Stratton Medal is given annually to two of their ability,” said Sherilynn legacy on diversity at Duke, including (left to right) Drs. Eddie Hoover, Jean Spaulding, and Delano issue contains 18 articles on topics including Meriwether. senior investigators, one in basic research and one in Black, director of Duke’s Office advances in genomics, Alzheimer’s disease, and electroconvulsive therapy. clinical/translational research. Dean Andrews received of Biomedical Graduate Diversity the award for basic research in the field of iron homeo- Funding was made possible with donations from the Bassett Fund, the in the School of Medicine, and School of Medicine Celebrates stasis. The award for clinical research went to Elaine departments of immunology and pharmacology, the Graduate Profession- co-leader of the grant. Jaffe, MD, of the National Cancer Institute, for her work al School Committee, and the Pratt School of Engineering. Legacy of African Americans; on erythropoiesis and lymphoma. “But for students from under- A copy of the journal is available by e-mailing Penumaka at represented groups, there can Leads Nation in Diversity of Students [email protected] also be a need to help them feel engaged in the scientific commu- When nearly 300 members of the Duke Uni- nity,” she said. versity School of Medicine and Durham com- School of Medicine, Duke Hospital munities came together in April to celebrate At both the graduate and under- the legacy of African Americans at Duke, they Top Ranked by U.S.News & World Report graduate levels, the BioCoRE pro- Duke University Hospital top learned just how much the medical school gram will have several activities Duke University School of Medicine moved up one ranked specialties included: has grown in regard to diversity. built on what Black calls “a com- place to rank 8th among medical schools that have a Pulmonology 4th munity engagement model.” The While 1963 marked the admission of the first research focus in the spring 2013 U.S.News & World Heart and heart surgery program will engage students black student to the School of Medicine, 2013 student. Jean Spaulding, MD’72, HS’72-’76, Report Best Graduate Schools ranking. 6th from the Pratt School of Engi- has found Duke leading the nation in diversity was the first African American female stu- The rankings are based on MCAT, GPA, NIH funding, Urology and neering, the School of Medicine, among predominantly white medical schools. dent, and Charles Johnson, MD, HS’65-’67, and student-faculty ratio, among other criteria. Duke ophthalmology, both 8th the Graduate School, and Trinity Duke’s medical school cohort includes 20 per- was the first black faculty member.Eddie placed in the top 10 in five specialty areas, including College of Arts & Sciences. cent African Americans—double the national Hoover, MD’69, HS’69-’71, was the first 4th in geriatrics, 5th in internal medicine, 6th in AIDS, Nephrology 11t h black house staff officer selected through the The program is Duke’s first average of 10 percent, according to the Duke and 8th in both family medicine and women’s health. national match program. Orthopaedics and award from a National Institutes University Office for Institutional Equity. There Duke University Hospital is again ranked number rheumatology, both 12th of Health program called the were nine medical schools in the U.S. that did April’s event celebrated the pioneers who 1 in North Carolina and is nationally ranked not graduate a single black physician in 2011, paved the way for future black medical Gynecology Initiative for Maximizing Student at 12th in the fall 2013 ranking of 13th Development. It should enable according to the office. students at Duke and showcased some of America’s Best Hospitals. Geriatrics 14th Duke to support up to 10 under- In 1963, the first five black undergraduates today’s most accomplished African American graduate students in each class, enrolled at Duke. At that time, the students. Three videos were shown, and can Cancer 18th plus about 20 graduate students university had no black faculty, adminis- be viewed at medalumni.duke.edu/fac- each year. trators, or trustees. Delano Meriwether, es-change. MD’67, became Duke’s first black medical

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Golden Apple Awards Hertz, Chadwick Duke medical students have chosen three outstanding Earn Top teachers to receive the Golden Apple Awards. BASIC SCIENCE TEACHING AWARD Student Honors

Matthew Velkey, PhD, is assistant By the time Robert Drucker, MD, was just a few words into his professor of the practice of med- introduction of the winner of the School of Medicine’s top stu- ical education in the Department dent honor (“This year’s recipient is a ‘super-senior’ in all senses Andrews Tsipis Pierce of Cell Biology. Velkey has been of the word…”), the only person in the room who might not at Duke for almost three years, have known who he was talking about was the person he was Three DukeMed having come from the Universi- talking about. ty of Michigan Medical School “It was a huge surprise,” says Julian Hertz, MD’13, recipient of (UMMS). He holds a PhD in cell Students Earn the 2013 Thomas Jefferson Award. “I think I was in shock.” and developmental biology from Schweitzer Fellowships UMMS and a master’s of science Hertz was the unanimous selection of the advisory deans for Velkey

the award, which is presented each year to the student who A trio of Duke University School of Medicine third- in anatomy from the University best exemplifies the ideals of scholarship, leadership, human- year students will spend the next year working of Mississippi Medical Center. ism, and service. BAER BRIAN to improve community health and developing He also received a BA in English Chadwick their lifelong leadership skills as Albert Schweitzer and a BS in biology, both summa “He’s a very gifted student, incredibly bright and accomplished, Fellows. cum laude, from Millsaps College. but he’s so humble and unassuming you would never know it to He has won several awards for meet him,” says Caroline Haynes, MD, PhD, Hertz’s advisor. Duke students Jon Andrews, Nicholas Tsipis, and teaching, including the Kaiser-Per- Brittany Pierce were among the 220 Albert Sch- Whitney Chadwick, MD’13, won the other major honor, the manente Award for Excellence in weitzer Fellows chosen for the 2013-14 national Arnold P. Gold Foundation’s Leonard Tow Humanism in Pre-clinical Teaching and the Pro- class. They will develop and implement Medicine Award. vost’s Teaching Innovation Prize, projects that will address the root caus- both from UMMS. This is the third Chudgar “It’s such an honor, especially since it’s an honor for humanism, es of health inequalities in vulnerable year in a row that he has received which is what we all strive for,” Chadwick said. “I hope I live up populations. a Golden Apple Award at Duke. to it.” Andrews and Tsipis’ project site is the CLINICAL FACULTY AWARD Hertz and Chadwick were honored, along with the winners of Durham Nativity School, a tuition-free academic and Dean’s Recognition Awards, at the annual School Saumil Chudgar, MD’05, private school for promising at-risk of Medicine awards ceremony. boys that offers support for an 11-year HS’05-’08, is assistant profes- Hertz decided on medical school after earning his undergradu- period from middle school through college. They sor of medicine in the Hospital JARED LAZARUS ate degree in chemistry at Princeton and then spending a year will work to increase the self-sufficiency of the Medicine Program and associate Hertz medical director for education working in a clinic in Haiti. middle school boys by providing survival and first- the medical record-keeping system. aid training. in the Department of Medicine. Leon-Guerrero “I saw a lot of suffering there,” says Hertz. “It was a very power- He teaches medical students and ful experience.” In Durham, Chadwick led the Duke in Durham community Pierce’s community site is Senior PharmAssist, residents in the care of inpatients service project to its largest and most successful participation, which promotes healthier living for Durham At Duke, he led teams of medical students on two spring break at Duke University Hospital. This is the second year in a served as one of the two program coordinators for the DukeMed seniors by providing health education, Medicare trips to provide care and service at the same clinic. He also spent row that he has received a Golden Apple Award, and in Elementary program, led a Project Compassion team, and was insurance counseling, community referrals, and ad- two third-year research terms in Tanzania, doing groundbreak- 2011 he received the Thomas Kinney MD Distinguished twice elected Service Vice President of the Davison Council. vocacy. She will work to improve communications ing work identifying an arbovirus that was frequently confused Teaching Award. “Whitney is very energetic, outgoing, a dynamic personality,” between seniors and health care providers. with Dengue Fever. In Durham, Hertz co-founded and led the HOUSE STAFF AWARD MedMentors Program, through which medical students provide said Drucker, who was her advisor. “I think the way she would This year’s class of Schweitzer Fellows will be mentoring, tutoring, life skills education, and other guidance for like to be remembered at Duke is through her community in- inducted during the 100th anniversary year of the Christopher Leon-Guerrero, MD, HS’10-’13, completed at-risk youths in the Durham Youth Home detention center. volvement and getting others involved in service.” building of The Albert Schweitzer Hospital in the a residency in neurology at Duke. He received an MD from Dean’s Recognition Award winners were: Simon Ascher, Christo- African country of Gabon. the University of North Carolina at Chapel Hill and complet- He is doing his residency in emergency medicine at Vanderbilt ed an internship in internal medicine at Carolinas Medical and plans to work in global health. pher Danford, Deeptee Jain, Jordan Komisarow, Navid Pourta- The fellowship program’s mission is to improve the Center before coming to Duke in 2010 to begin his residen- heri, Nino Mihatov, Hannibal Person, Brian Steiner, Fallon Ukpe, health of vulnerable populations now and in the Chadwick did service overseas, too, leading a team of nine med- cy. He is now on a one-year fellowship in vascular neurology and Lindsey Wu. future by developing a corps of leaders in service. ical students on a second-year elective experience in Kampala, at Washington University in St. Louis. Uganda. She and her fellow students worked for a month at Academic Awards were presented to: Jake Berchuck, Gabe Grif- Mulago Hospital, where she initiated her own project to improve fin, and Julian Hertz.

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Orthopaedics, vice chair for research in focuses on advanced CT methods and Neurology Becomes the Department of Surgery, and interim reducing the amount of radiation patients a Department director of the Toronto Musculoskeletal receive during CT scans. Centre. Alman also was a senior scientist In July, with Duke University Board of in the Developmental and Stem Cell Biol- Trustee approval, the Division of Neurol- ogy Program at the Research Institute of Duke to Offer ogy was elevated to department status. The Hospital for Sick Children in Toronto. Alman’s clinical practice focuses on the Leadership Program care of children with syndromes, spinal in Integrative deformity, neuromuscular disorders, and tumors involving the bones, joints, and Medicine soft tissues. In basic science research, he studies the role of developmental A $1.4 million grant from The Bravewell signaling pathways in musculoskeletal Collaborative will allow Duke Integra- tumors and reparative processes. He has tive Medicine to offer the nation’s first won numerous awards for research, most leadership program in integrative health recently the Lodwick Award for the best care. Set to begin in January 2015, the Interim chief Joel Morganlander, MD, publication in the musculoskeletal field program will train and mentor health care HS’91, will serve as interim chair while and the Charles Tator Surgeon-Scientist leaders prepared to transform the practice a formal search is conducted. “This is Mentoring Award. of medicine and improve health through an important step for neurology,” said a patient-centered, personalized, and Dean Nancy Andrews. “Nearly all medical prevention-oriented approach. schools and all of our peer institutions Paulson Returns to Integrative health care seeks to integrate have departments of neurology, and this the best of Western scientific medicine move will create an even stronger pres- with a broader understanding of the The new Duke Medicine Pavilion provides efficient, patient- and family-friendly care. Head Radiology ence for Duke Neurology nationally.” nature of illness, healing, and wellness, ac- The School of Medicine now has seven Erik Paulson, MD’85, HS’86, has returned cording to Adam Perlman, MD, executive basic science departments, 14 clinical de- to Duke after spending a year as professor director. Duke’s one-year training program Duke Medicine partments, and 12 centers and institutes. and chairman of the Department of Diag- will begin with personal transformation Pavilion Opens and provides tools for systems reorganiza- tion and change. It includes two in-person Number of levels: 8 Duke University Hospital officially opened the new Alman to Lead retreats, an extensive online curriculum, Square footage: 608,000 Duke Medicine Pavilion in June. The first major expan- and a personal mentorship experience, all Key components: sion of the hospital since Duke North opened in 1980, Orthopaedic resulting in the creation of a business plan • 160 critical care beds the state-of-the-art building is designed to provide for each participant’s individual goals and • 18 total operating rooms efficient, patient- and family-friendly care and meet Surgery work environment. Features: the increasing demand for Duke medical services and • Intraoperative surgical priority programs. Benjamin A. Alman, MD, has been “There is an urgent need and unmet imaging appointed chair of the Department of Or- demand for world-class executives with The eight-floor, $600 million, 608,000-square-foot pa- the qualifications, competencies, and • Natural-light filled vilion includes 160 critical care rooms and 18 operating nostic Radiology at M.D. Anderson Cancer leadership attributes to build, sustain, and public spaces, patient rooms, including two with intraoperative MRI and CT. It Center. He was educated and trained at grow integrative health care programs and rooms, and staff is LEED silver certified, with spectacular views of Duke Duke and spent 20 years on the faculty, institutions across the United States,” said work zones Chapel and the medical center campus, spacious and most recently as chief of the Division of Christy Mack, co-founder and president of • Café comfortable waiting areas equipped with flat screen Abdominal Imaging and vice chairman of The Bravewell Collaborative, a community • Gift shop televisions, larger patient rooms with family zones, natu- the Department of Radiology. of philanthropists dedicated to bringing • Interfaith chapel ral light wells, courtyard gardens, and patient amenities Paulson is an expert in cross-sectional about optimal health and healing for indi- Sustainability features: including a café, an interfaith chapel, and a gift shop. imaging of the abdomen and has built an • Green roof space viduals and society. “The program at Duke The building opened for the public in June. Hospital academic career around clinically driven • Use of sustainable will fill the void by creating leaders pre- staff spent months training on the new equipment and research, including cross-sectional imag- building materials thopaedic Surgery, succeeding James A. pared to implement integrative strategies preparing to move patients. In July, a total of 86 inten- ing of the liver, assessments of computed Nunley, T’69, MD, HS’79. Alman comes across a variety of health care settings. sive care patients were successfully transferred to the tomography (CT) technology, and new from the University of Toronto, where he new ICU facilities. Plans are now underway to renovate image-guided interventions. Recent work was the A.J. Latner Professor and chair of Duke North Hospital. JARED LAZARUS

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the $3.25 billion Duke University-wide fundraising campaign launched in Sep- Faculty Attend tember 2012. He is also on the planning Medical Mystery Dinner committee for Medicine that Changes the World, Duke Medicine’s $1.2 billion In May, David Trice, T’70, and his wife Kathy Houston, Texas, fundraising effort. joined Dean Nancy Andrews; Vice Dean for Research Sally Korn- “I see a great opportunity for Duke bluth, PhD; and Duke clinical and basic science faculty members Medicine to differentiate itself in sports for dinner and conversation exploring a research mystery in medicine,” said Scott, a member of the the neurosciences. The research mystery focused on promising Duke University Health System Board of research by Dean Andrews that involves a potential drug pathway Directors. “I truly believe Duke Orthopae- in Parkinson’s disease. The dinner was the first in a series where dics is one of Duke’s signature programs, Duke basic and clinical scientists gather for free-ranging discus- and I hope this gift will benefit both the sion on an unsolved medical challenge. The Trices have given $1 department and Duke University School million to the School of Medicine for the Holland-Trice Scholars of Medicine.” Program, which provides four $50,000 faculty research grants annually and one $35,000 graduate student fellowship. Expe- In October 2012, the Scotts committed LES TODD rience at Duke has shown that modest funding for early-stage $10 million to Duke Athletics to help A lively after-dinner discussion ensued, with David and Kathy Trice research can lead to grants of more than 20 times the initial support the activities and programs in a and Sally Kornbluth actively listening. CHRIS HILDRETH CHRIS investment. new 35,000 square foot building that will James Urbaniak, professor of orthopaedic surgery; Steven and Rebecca Scott; and Chancellor Victor J. Dzau. house ticket offices, a team store, and training rooms. Campaign Surpasses 2013 was Record Breaking for Scott is the retired chairman of the support for the School of Medicine. the Halfway Mark Medical Annual Fund and Davison Club Scotts Give $20 medical investment company Scott Hold- Under the direction of Claude T. Moor- ings, LLC. He also serves as an assistant Fiscal year 2013 was the second highest The Medical Annual Fund surpassed its annual goal of $1.4 million this fiscal year. Million for Sports man III, T’83, MD, HS’93, Duke Sports consulting professor of obstetrics and performing year in Duke Medicine history, As of June 25 gifts to the Medical Annual Fund totaled more than $1.5 million. The Medicine currently comprises the Duke gynecology in the School of Medicine, with a total of $119 million raised toward Davison Club, recognizing donors of $1,000 or more to the Annual Fund, grew by 62 Medicine Sports Medicine Clinic, Duke Sports Med- president of the Scott Family Foundation, the fiscal-year goal of $85 million. The members, a 15 percent increase over 2011. icine Physical Therapy, the Michael W. Steven Scott, MD, HS’74-’78, and and a member of the Board of Trustees at seven-year Duke Forward: Medicine that Krzyzewski Human Performance Lab, and his wife, Rebecca, committed $20 the University of Florida. The Scotts, who Changes the World campaign passed the the Duke Sports Performance Program. It million to expand Duke’s sports med- live in Boca Raton, Fla., have five children, halfway mark in April, and as of June 30 a New Director is a division of the Department of Ortho- icine programs, including clinical and including two who currently attend Duke total of $676 million had been raised to- paedic Surgery. research program development, faculty medical school. ward the $1.2 billion overall Duke Medicine of Medical recruitment and retention, and support Scott is a member of the Campaign campaign goal. Alumni Affairs for sports medicine training, as well as Steering Committee for Duke Forward, The School of Medicine’s portion of the campaign goal is $970 million, with a total Grace M. Taylor, T’81, has been ap- of $353 million raised as of June 30. The pointed director of alumni affairs for SPOTLIGHT on goal includes $11 million for the Medi- the School of Medicine. For the past Duke Medicine! cal Annual Fund; $50 million in capital two years, she was assistant director for Taylor funds for new buildings, equipment, and regional affairs with the Duke University On Thursday-Saturday, November 7-9, Duke Medicine will host programs; $135 million in endowed funds Alumni Association, where she focused From 1992-98, Taylor worked in Duke Spotlight, a campaign event for top donors and volunteer board spot light for research, fellowships, faculty support, on alumni programming and engage- Medicine Development, serving as members. The event features a Gala Reception and Dinner with and financial aid; and $774 million in ment activities on the West Coast and director of special events and donor keynote speaker Sanjay Gupta, MD, CNN chief medical corre- Medicine that Changes the World current-use funding that can be immedi- in some Mid-Atlantic and Northeastern relations. From 1998-2010, she owned states. She worked closely with alumni and operated Taylor Made Events, an spondent, and a High-Impact Philanthropy Panel moderated DUKE MEDICINE EVENT ately applied to research, technology, and by David Rubenstein, T’70, managing director of The Carlyle education. during the rollout of the One Duke event consulting business. program, taking responsibility for four Group and chair of the Duke University Board of Trustees. Robert NOVEMBER 7-9, 2013 The campaign was publicly launched to- A native of Philadelphia, Taylor attended major regions—northern California, Lefkowitz, MD, winner of the 2012 Nobel Prize in Chemistry and gether with Duke University’s $3.25 billion Duke on a swimming scholarship and southern California, Philadelphia, and James B. Duke Professor of Medicine, will speak at a Thurs- Institute, Duke Children’s, Duke Eye Center, heart and heart campaign in September 2012 and will end graduated magna cum laude with a dou- Boston—to create coordinated alumni day dinner for all Duke Medicine volunteer boards. On Friday surgery, medical and nursing education, basic science research, June 30, 2017. ble major in political science and French. afternoon, guests may participate in interactive Duke Medicine transplantation, and other topics. The weekend concludes with programming across the university. tours, featuring research and clinical faculty from Duke Cancer the Duke-NC State football game.

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BIOENGINEERED BLOOD VESSELS A 15-Year Journey of Discovery

JEFFREY LAWSON, MD, PHD, HOLDS OUT ONE HAND, palm grown from human cells in the lab, stored indefinitely on the flat and fingers pointed straight up, and slowly raises it straight shelf, and then transplanted into patients when needed. toward the ceiling. “It was like watching a rocket take off,” he says. “You stand there watching it go up, and then—“ “This is a paradigm shift,” says Niklason, who was on the His hand reaches eye level, and then slows, traces an arc, faculty at Duke until 2006 and is now a professor of anes- and plummets back toward the floor. “Boom.” thesiology and biomedical engineering at Yale. “To the best Lawson looks up and smiles. “Back to the drawing board,” of my knowledge nobody else in the world has done this, and he says. certainly nobody has taken it into the clinic. This opens a lot of doors.” Jeffrey THE REMARKABLE JOURNEY OF DISCOVERY taken by The world at large recognized that immediately. Breakley’s Lawson, a vascular surgeon and biologist, and his former Lawson surgery made headlines throughout the country and across the Duke colleague Laura Niklason, MD, PhD, to successfully globe, and in the weeks and months afterward Lawson and create and implant a bioengineered blood vessel included more Niklason found themselves giving interviews to journalists such back-to-the-drawing-board moments than the researchers from places as diverse as Iran, Greece, and Brazil. can count. “I expected some attention, but honestly, probably not quite But each one of those hurdles—each chemical formulation as much as we’ve gotten,” says Lawson. “But it is an intriguing that lacked sufficient cohesion, each attempt that failed to story for a lot of reasons, from human interest to medical grow the requisite cell layers, each animal prototype that technology, to a good message about advances in biomedical ruptured under stress—taught them something. research. People are fascinated by the fact that we’re making And each of those lessons was a stepping stone that human tissues.” ultimately led to the first successful implantation of a bioen- Even after all these years of working on the project, Lawson gineered blood vessel in a human being by a Lawson-trained and Niklason are among those people. surgical team in Poland in late 2012, and the day in June 2013 “Sometimes I pinch myself and think, ‘Wow, I get to be a when Lawson stitched a bioengineered blood vessel onto the part of all of this,’” Lawson says. artery of a Virginia hemodialysis patient named Lawrence For her part, Niklason says, “It’s been 18 years of hard Breakley in a Duke University Hospital operating room, the work, but it still seems sort of amazing that it works.” first such procedure in the United States. The accomplishment shows every sign of being one of those AN IMMENSE CLINICAL NEED rare breakthroughs that represents a truly new horizon in The surgery to implant the new blood vessel in Breakley’s medicine. Building on the work Lawson and Niklason have arm took just two hours, but it represented the culmination of done, it’s hard not to envision a future when not only blood almost two decades’ worth of work and research. Lawson and vessels but all sorts of replacement tissues and organs may be Niklason teamed up in the late 1990s when they discovered

By Dave Hart SHAWN ROCCO SHAWN

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they each had an interest in finding a better process for Making a bioengineered grafting blood vessels. The need was, and is, immense; every year many hundreds blood vessels of thousands of patients in the U.S. require replacement of blood vessels for heart bypass, hemodialysis, peripheral artery disease, and other conditions. The standard process is to graft either veins taken from elsewhere in the patient’s own body or synthetic blood vessels onto the affected artery. Cells are “fed” with a special amino acid solution within a 2. Cells are “fed” with a special amino acid solution within a Both procedures are fraught with problems. Many patients Human arterial cells are seeded into the Takes up to 3 weeks. 2.bioreactor. Cells are The “fed” human with cells a special grow aminoand establish acid solution themselves within in a the bioreactor. The human cells grow and establish themselves in the don’t have sufficiently robust or healthy veins to harvest. Veins scaffolding made of Polyglycolic acid Length -- 16.5” (42 cm) bioreactor.scaffolding. The The human scaffolding cells biodegradesgrow and establish over a themselvesfew weeks whilein the scaffolding. The scaffolding biodegrades over a few weeks while and arteries are structurally different organs, and using veins 1 (PGA). The cells come from tissue and scaffolding.the cells produce The scaffolding extracellar biodegrades matrix proteins, over primarily a few weeks collagen. while the cells produce extracellar matrix proteins, primarily collagen. to do the job of arteries seldom works very well. And, even organ donors. A silicon tube (shown in theThe cells solution produce is pulsed extracellar into a matrixsealed proteins,sterile plastic primarily bag. Takescollagen. up to gray) provides support for scaffolding and The solution is pulsed into a sealed sterile plastic bag. Takes up to in the best cases, harvesting a patient’s own veins requires an The2 months. solution is pulsed into a sealed sterile plastic bag. Takes up to pulsation during growth. 2 months. additional surgical procedure, with another incision site, and 2 months. increased operative time, cost, recovery period, and potential for complications. Synthetic blood vessels are prone to clotting, rejection, and other complications. “Natural blood vessels work in a way that is very different from a plastic tube, and an artery is very different from a vein,” says Lawson. “Laura and I, from different perspec- Cells are “fed” with a special amino acid tives—me from the surgical perspective and she from her Takes up to 2 months. solution within a bioreactor. The human While in the bioreactor experience as an anesthesiologist watching surgeons struggle 2 cells grow and establish themselves in the the silicone tube is pulsed to harvest veins—both came to the conclusion that there has scaffolding. The scaffolding biodegrades to mimic a heartbeat. Laura to be a better way.” over a few weeks while the cells produce While in the bioreactor Niklason began working on that problem as a post-doc at extracellar matrix proteins, primarily the vein is kept at 98.6 F Niklason the Massachusetts Institute of Technology. collagen. The solution is pulsed into a sealed sterile plastic bag. “I remember watching surgeons dig around in the legs or abdomens of patients trying to get veins for bypass,” she said. “I thought, ‘This is sort of a barbaric process. Do we not know enough about blood vessels to grow our own in the lab?’” TRIAL AND ERROR Shortly after Niklason arrived at Duke in 1998, she and Lawson met over an operating table and soon discovered their shared interest in improving vascular grafts. They joined forces to build on the work she had begun. Although some Human cells are stripped out of the vein, Takes up to 1 week and in a process called decellularization. The then the vein can be bioengineered tissues had been developed at the time, the idea 3 remaining structure is mostly collagen. stored in the hospital until of growing blood vessels from human cells was still “a little bit The vein is still contained within the same needed for a patient. out there on the lunatic fringe,” Niklason says. plastic bag. It will not be removed until the Presently the veins are In Lawson, she found the perfect collaborator, and at Duke, patient is in the operating room. being implanted in patients who undergo the perfect institution. hemodialysis. The new “Her background is in bioengineering, mine is in vascular vein allows health care biology, so we had different but complementary skill sets,” workers easier access for Lawson says “And at Duke we were in an environment that dialysis and decreases the chance of infections. allowed us to collaborate, and we had supportive departments that allowed our collaboration to flourish. For a project this SOURCE: HUMACYTE complex, you require that interdisciplinary, multi-faceted approach. We’ve probably had 20 or 30 grad students, medical students, and post-docs working with us along the way.”

SHAWN ROCCO SHAWN By the time she got to Duke, Niklason had developed a

12 | DukeMedAlumniNews DukeMedAlumniNews | 13 COVER STORY

workable version of the first essential component: immune response,” Niklason said. THE RIGHT TREE a biodegradable “scaffolding,” a tube-shaped mesh “That means we can store it for Lawson followed the initial operation up with several more in structure that could be made in various lengths and “ remember months, and if somebody needs an the following weeks, with still more on the way. widths. The idea was to “seed” smooth muscle cells saying at the artery we can take it off the shelf and Thus far, all indications are that the grafts done both in onto the scaffolding and immerse it in a stew of amino I put it in the same day.” Poland and in the U.S. are working just as the researchers time that this rep- acids and other nutrients within a “bioreactor,” a What they found next, when they projected they would. Assuming the grafts in dialysis patients’ container that would mimic the temperature and resents 15 years implanted the new blood vessels arms continue to function without complications, the plan environment inside the human body where cells of Duke-supported in baboons, was in some ways the is to begin using the new blood vessels to treat peripheral naturally grow. research from most remarkable aspect of the whole artery disease (PAD) and then, at some point in the future, for The cells would grow and adhere together—“It’s multiple depart- project. Not only does the host’s coronary bypasses. basically like growing grass seed,” says Lawson— and body not reject the new blood vessel And ultimately, Niklason says, the potential exists to use the scaffolding would dissolve, ultimately leaving ments and multiple as foreign—the body’s own cells the same technology to grow many other sorts of tissues—for behind a solid, flexible tube made of muscle tissue. investigators.” quickly start to populate the new respiratory, gastrointestinal, and urinary tracts, for example. It’s easy to visualize, but it was very difficult to do. Jeffrey Lawson vessel, like new people moving into But one step at a time, she cautioned. What the researchers Every step—creating a scaffolding that would support an empty building. have already accomplished is breathtaking. the structure but dissolve at the right rate, developing “To me, that’s the most exciting, “It’s gratifying and exciting and scary all at the same time,” the bioreactor, finding the right combination of fascinating, science fiction-y part of says Niklason. “If you work on something your whole adult nutrients to grow the cells—required a laborious process of this whole thing,” says Lawson. “Within a few weeks, it’s no life and now it’s being tested, you hold your breath a little bit.

trial and error. longer our structure at all. It’s your blood vessel, made up of JARED LAZARUS It has huge implications for the patients, obviously, because we “There was a lot of tinkering, a lot of prototyping,” says your tissue. It becomes a part of you.” want them to do well. But it’s also the moment when you find Lawson. “It was, ‘Let’s add more Vitamin C, let’s try this or out whether you’ve been barking up the right tree this whole INTO THE OPERATING ROOM that.’ Each one was like, ‘Put a little more salt in the sauce.’” time. And so far, it looks like we have.” By 2012, after a series of successful trials in baboons, the They experienced, Niklason says, “a very large number of researchers were confident they had developed a technology NEXT STEPS failures. But bit by bit we solved the problems.” that would work and would prove superior to the existing That doesn’t mean the hurdles are over. Probably the biggest A COUNTERINTUITIVE BREAKTHROUGH methods of vascular grafts. They applied for regulatory immediate challenge is economic: Can bioengineered blood After many attempts and adjustments they came up with a approval to begin human trials in both the U.S. and in Poland, vessels be manufactured and implanted at a cost that will make process that consistently produced arteries strong and stable and Niklason founded a spinoff biotechnology company called them widely available in the health care marketplace? That is enough to function properly when implanted in pigs. Once Humacyte to manufacture the blood vessels in quantity in a tremendously complicated equation, involving production they had solved that challenge, though, the researchers found 2005. scale, up-front costs versus long-term savings, competition from themselves facing another. They had proven that they could The Polish regulatory mechanism moved more swiftly than synthetic vessel manufacturers, and many other factors. grow a new blood vessel from an animal’s cells and success- the one in the U.S. Teams of Polish surgeons came to Duke “You can make the coolest, fanciest thing, but if it’s unob- fully implant it into the same animal. But from a practical to operate with Lawson, and he went there to oversee the tainable with the health care dollars we have, it will die an

standpoint, doing the same thing in humans posed a big procedures, and in December 2012, a team of surgeons from ROCCO SHAWN economic death,” Lawson says. “I wouldn’t be talking to you if problem. Poland implanted a bioengineered blood vessel in the first At top, a network of tubes feed a nutrient solution to bioengineered I didn’t think it was going to work, but the biggest challenge in “We could make your own blood vessel for you, but we human patient. Since then, 20 other implants have been done blood vessels as they grow in sterile plastic bags within a bioreactor. the next two to five years will be the business model viability.” Below, in the first procedure of its kind in the U.S., Dr. Jeffrey Lawson needed a three to four month lead time—and if you need a at three sites in Poland. and his surgical team prepare to graft a section of bioengineered blood As Lawson describes the long journey and the many hurdles heart bypass or a bypass around a circulation blockage in “I remember saying at the time that this represents 15 years vessel into the arm of a hemodialysis patient. the researchers had to overcome, he shakes his head in wonder your leg, you usually don’t have four months to wait around of Duke-supported research from multiple departments and at how many times an idea that seemed a little off the wall at for it,” Lawson says. “We needed to be able to grow them in multiple investigators,” says Lawson. lose your leg or have a stroke or a heart attack,” says Lawson. the time turned out to the be the solution. batches and have them available. Growing them from the host Several months later the FDA signed off on U.S. trials, and “If it fails or shows any sign of weakness or rejection, we’ll be “So many of these breakthroughs were dumb-luck things,” one at a time isn’t going to work. But at the same time, if we Duke gave its go-ahead. Lawson selected Lawrence Breakley, able to see that and deal with it, because it’s right under the Lawson says with a smile. “Somebody says, ‘Hey, how about make the structure from your cells and put it in me, my body a 62-year old man from Danville, Va., with end-stage renal skin, not deep in your leg or in your chest cavity.” we try it this way?’ ‘OK, give it a shot!’ That’s the nature of would identify it as foreign. How do we make it universally disease, for the first U.S. procedure. He is one of the 350,000 On June 5, 2013—in Operating Room (OR) 17 at Duke research. I love that quote from Albert Einstein: ‘If we knew transplantable? OK, back to the drawing board.” people in the nation who needs hemodialysis, a thrice-weekly University Hospital, the same OR where Lawson and Niklason what we were doing, it wouldn’t be research.’” The answer was deceptively simple, if somewhat procedure that draws blood, filters toxins out of it, and then first met 15 years earlier—Lawson grafted a length of bioen- And they aren’t done yet. In some ways, with the trials counter-intuitive. returns the cleansed blood to the system. Prior to the bioengi- gineered blood vessel onto an artery in Breakley’s arm. By all under way, the next series of procedures on the horizon, and They devised a process by which, after growing a vessel neered vessel graft, Breakley was out of options: both natural indications, it was a complete success. Humacyte working on the manufacturing and business end, from a donor’s healthy cells, they “decellularize” it, washing it and synthetic grafts in him had failed. “It’s amazing, you know, the things they can do,” Breakley they’re just setting out. in a solution that rinses away the living cells. What is left is a “Dialysis is the safest place to test emerging vascular told a local newspaper after the operation. “At the rate they’re “Laura and I sometimes tease other,” says Lawson. “We flexible tube of collagen that is immunologically neutral. technologies, because it meets the fundamental requirements going, eventually there won’t be any part of the body they tell each other, ‘Fifteen years down the road, we’re at the end “It’s still a tissue, but it’s non-living, so it doesn’t trigger an for what you need a blood vessel to do, but if it fails you don’t won’t be able to give (patients).” of the beginning.’”

14 | DukeMedAlumniNews DukeMedAlumniNews | 15 FEATURE

HOW THE JARED LAZARUS

USING METABOLITES TO PREDICT AND PERSONALIZE

alking through glass-walled Wlabs to the back of the Sarah W. Stedman Nutrition and Metabolism Center, Chris Newgard T’78, PhD, enters a large windowed room and says, “This is my baby.” He’s referring to the metabolomics lab, which houses seven mass spectrometers. He points out one machine in particular, a liquid chromatography quadrapole time- of-flight mass spectrometer. It doesn’t look especially impressive—like three small, white air conditioners in a row, with a smoke stack on top. But to Newgard, it’s a Rolls-Royce. Because he’s a biochemist, this machine can tell him a story. Newgard (above, right) The mass spectrometer separates a blood talks with Olga Ilkayeva, PhD, director of the sample into all its components, according to Metabolomics Core Lab, in front of one of the Stedman their charge and mass. Center’s seven mass Knowing the mass of a compound enables spectrometers. a biochemist to identify it. Is it a lipid, an On a map of the human body’s metabolic pathways, amino acid, a sugar? These compounds in pink flags mark all the metabolites for which the blood are byproducts of something that Newgard’s team has happened inside the body—the breakdown developed an internal standard—a method of precisely measuring the by Angela Spivey exact amount present in a blood sample. 16 | DukeMedAlumniNews DukeMedAlumniNews | 17 FEATURE

THE DUKE INSTITUTE FOR MOLECULAR PHYSIOLOGY

of fat or glucose or protein for fuel. When PhD’93, professor of medicine. Together, not seeing patients, Shah looks for the researchers started by measuring of the Center for Human Genetics. • As of July 2013, the Duke these byproducts, known as metabolites, they will form one enterprise called the something better. As a member of changes in levels of about 70 metab- “Chris picked it up biochemically, and Institute for Molecular show up in the blood, they can tip off a Duke Institute for Molecular Physiology. Duke’s Center for Human Genetics, olites—those that would be likely to the computer, unbiased, picked it up Physiology combines the biochemist as to what is going right and Their goal is ambitious: to draw a complete she, along with Bill Kraus and Elizabeth be involved in heart disease. Some too,” Shah says. Sarah W. Stedman Nutrition what is going wrong. picture of almost any human disease that is Hauser, PhD, director of the Center for are lipids, some are amino acids (the In two handfuls of studies published and Metabolism Center, One complication: these metabolites lurk heritable. “If someone brings us a disease, Human Genetics, have worked with building blocks of protein), others over the past five years, the team the Duke Center for Human in the blood in tiny concentrations—on the we want to have the tools to study it,” Bill Newgard to find ways to predict who is are hormones involved with signals reported that elevations in a cluster of Genetics, and the labs of micromolar and nanomolar levels. Most Kraus says. at greatest danger from heart disease. of hunger and fullness, while still metabolites—short chain dicarboxyl- Duke researchers William proteins normally measured in blood are This work was made possible by the others are byproducts of breakdown of ated acylcarnitines, if the name means Kraus MD’83, HS’83-’88, WHAT’S SO GREAT present at levels that are at least ten times CATHGEN database, which Bill Kraus proteins or carbohydrates. Once they anything to you—can identify people and Virginia Kraus, MD’83, ABOUT PHYSIOLOGY? that. For two decades, Newgard, the W. and several other investigators founded. had the reams of mass spectrometry who will have a heart attack or die HS’83-’89, PhD’93. When Newgard first joined the faculty at David and Sarah W. Stedman Distinguished In 2000, the database began collecting data, the team narrowed down the from heart disease even when clinical Duke in 2002, the School of Medicine no • Basic and clinical researchers Professor of Medicine and Pharmacology DNA and serum samples from patients original set of 70 metabolites to just a signs can’t. “We can take somebody’s longer had a department of physiology, and from a wide range of dis- and Cancer Biology, has refined his undergoing cardiac catheterization at few clusters that are elevated in people blood right now and predict up to seven he’s credited with putting the discipline ciplines will operate under methods for measuring trace levels of Duke University Medical Center who with more serious problems. When a or eight years in the future what their back on the map here. “Physiology is one roof with advanced these metabolites and understanding their consented to be included. Shah was a set of results come in, Newgard might risk will be of dying of heart disease or the overall operation of a living system,” capabilities and expertise in significance. For instance, for many of cardiology fellow at Duke at the time spend days sitting in a room poring over having a heart attack,” Shah says. Newgard says. “How do all the parts fit metabolomics, genomics, the metabolites he measures, the Stedman and helped collect some of the early spreadsheets that catalog the metabolite together so that you and I can sit here A NOVEL PATHWAY physiologic profiling, and Center metabolomics laboratory has an samples. CATHGEN is tied to the levels. He’s looking for a coherent story. as organized human beings? There’s a FOR HEART DISEASE computational biology. internal standard—a method of spiking the Duke Databank for Cardiovascular Which of the elevated metabolites would tremendous amount of crosstalk between This metabolite cluster is ripe for sample with a known amount of a separate Diseases, which collects clinical infor- cluster together logically? Which share a • The institute will be largely our tissues, between products that are in development into a commercial clinical compound that will show up on the mass mation about each of the patients in transporter? How are the liver metabo- self-supporting, with an our blood interacting with receptors on test. But there are hurdles to that. First, spectrometry peaks next to the metabolite CATHGEN and follows up with them lites changing in relation to those from expected funding mix of cells. We want to take a step back and the predictive value of the metabolites of interest. Since Newgard knows the exact yearly. the muscle? The team also analyzed 40 percent government understand the whole system.” This type will need to be verified in larger studies, amount of the standard he added, he can, Using samples and data from which clusters were correlated statisti- grants, 20 percent industry of work has also been called systems Shah says. The Duke research to date by comparison, measure the exact amount CATHGEN and the Duke databank, cally, using the bioinformatics capability investment, and 20 percent biology—using sophisticated tools like has found them to be predictive in of metabolite the sample contains. foundation funding. metabolomics, genomics, and proteomics to Newgard, in collaboration with research- view all the happenings inside the body as ers across the School of Medicine, uses one integrated whole. metabolites to try to understand some of Svati Shah, MD, HS’01-’05, MHS’05, the most common and devastating dis- associate professor of medicine, is a eases—cardiovascular disease and diabetes. cardiologist who founded and runs an adult The team has found that elevations in cardiovascular genetics clinic where people certain metabolites can serve as early with a family history of heart disease can markers of heart disease and of insulin come to receive genetic testing to determine resistance and diabetes. their risk. She has tools she can use to Some of these metabolite clusters might predict whether a patient is at high risk for one day be developed into clinical tests that heart attack or dying from heart disease in can identify patients at high risk. Others the future. “When someone’s overweight or are helping researchers understand why has diabetes or has bad cholesterol levels, I people get these diseases. But they aren’t can predict with about 70 percent accuracy the whole picture. Ultimately, Newgard and whether they will have a heart attack or die his collaborators want to understand all of heart disease in a few years,” says Shah, the processes that make our bodies able to associate professor of medicine. “But 70 function every day. That’s why the Stedman percent isn’t good enough. We’re talking Center is merging with several other Duke about people who may die.” labs—the Center for Human Genetics; So, in the three days a week when she’s the lab of William “Bill” Kraus, MD’83, HS’83-’88, professor of medicine; and the lab of Virginia Kraus, MD’83, HS’83-’89, Christopher Newgard and Svati Shah in the Stedman Nutrition and Metabolism Center, which is merging with several other groups to form the Duke Institute for Molecular Physiology.

18 | DukeMedAlumniNews DukeMedAlumniNews | 19 “That’s one reason why metabolomics tools are so attractive: they have potential to people who had already come in with chest be the only mechanism for development of personalize medicine pain or some other symptom that caused type 2 diabetes, Muoio says, but it’s one Duke by identifying them to get a diagnostic cardiac catheteriza- possibility. University School of Medicine individuals who tion. But are they predictive in the general In animals and in a small study with population? Second, to be made into a humans, Muoio has found that mitochon- are most likely practical, affordable test, the cluster would drial buildup of the troublesome metabolites to benefit from need to be narrowed down to just one or a is reduced when she supplements the diet specific nutritional few metabolites. Such development work with carnitine (a substance that our body or pharmacological will require an industry partner. makes and that is found in meat and other In the meantime, the metabolite findings foods), without changing anything else approaches.” have helped the Duke researchers in their about diet or exercise. “Carnitine shuttles Deb Muoio search for clues to the causes of heart the bad metabolites out of the mitochon- disease. The team analyzed the genomes dria, alleviating the traffic jam and reducing of patients from CATHGEN to find out cellular stress,” Muoio says. “This seems to if people with elevations in particular be an effective anti-diabetic strategy, at least metabolites had any genetic variants in in a subset of people. Maybe some people Medical common. They did, and those genes are have plenty of carnitine, but for whatever part of a pathway not previously thought reason, genetic or otherwise, other individ- Alumni to be involved in heart disease. “It’s like uals might have insufficient amounts. In the we were looking for Waldo all over the second case, carnitine supplements appear United States,” says Bill Kraus. “Analyzing to boost a defense mechanism that helps the Weekend the metabolites helped us to get to the state mitochondria cope with excess nutrients. level. Then we could narrow it down from That’s one reason why metabolomics tools October 17–20, 2013 there.” The researchers have submitted the are so attractive: they have potential to per- results for publication. sonalize medicine by identifying individuals who are most likely to benefit from specific A TRAFFIC JAM THAT nutritional or pharmacological approaches.” LEADS TO DIABETES? Muoio studies the traffic jam in animals Deb Muoio, PhD, associate professor in the and people who eat a high-fat diet. departments of medicine and pharmacol- Newgard has been studying a different ogy and cancer biology and the Stedman You’ll see a transformed campus—with the new Trent Semans mechanism for type 2 diabetes, in which Center, is a long-time athlete who studies Center for Health Education, Duke Cancer Center, and Duke metabolites known as branched chain what happens inside the body when people Medicine Pavilion. amino acids are elevated, in animals who eat too much and don’t exercise enough. are fed too much protein. As it turns out, She has found metabolite profiles that Newgard’s work and Muoio’s work appear • Celebrate with the Medical Alumni Association Award winners are predictive of insulin resistance and to be converging; the mechanism he is at the Thursday night reception and dinner. diabetes. Some of these metabolites are studying may also involve stress to the related to what she calls “nutrient stress” • Attend Clinical Science Day (CME credit approved for AMA PRA mitochondria. inside mitochondria, which are cellular TM As Muoio describes it, it’s like these Category 1 credit ) on Friday afternoon, and hear talks by Duke engines that produce energy. Based on researchers are trying to put together a physician faculty, with a keynote address by pediatric surgeon these findings, Muoio thinks that the gigantic jigsaw puzzle when many of the Kurt Newman, MD’78, president and CEO of Children’s National road to diabetes involves a “traffic jam” pieces are missing. Every so often, by Medical Center inside mitochondria. “The carbs, fats, and working together, the group finds a new protein we eat are made of carbon and • Join Nobel laureate Robert Lefkowitz, MD, and Dean Nancy piece and determines where it fits. “We may get used as mitochondrial fuel,” Muoio not have all the pieces of the puzzle in the Andrews for the Dean’s Brunch Saturday morning says. But when sedentary muscles are right order, but each new study provides a fed too much fuel, the carbons build up • Class Dinners and Dessert After Party Saturday night new clue, and eventually a clearer picture rather than being burned. The overloaded begins to emerge,” she says. mitochondria must work over time, and For a complete schedule and more information, eventually, these engines fail. That may not please visit medalumni.duke.edu.

20 | DukeMedAlumniNews Come back to revisit, reconnect, rekindle FEATURE

n its relatively short history, Duke University School of IMedicine has earned a reputation for its ability to prepare leaders in all areas of medical practice, education, and research. Yet, pinpointing exactly when and how that leader- ship training occurs over the course of a student’s studies at Duke could be difficult. That is, until now. As of this fall, the school has officially incorporated lead- ership training into its curriculum with the new “THIS CURRICULUM Duke Leadership, Education, and Development WASN’T ABOUT (LEAD) Program. Created by medical students, the program focuses on developing students’ leadership ADDING ON skills throughout their years at Duke, whether they MORE CLASSES dream of one day reaching department chair or LEADing CEO status, flying solo as a practitioner, or landing BUT REPURPOSING somewhere in between. The LEAD Program is one of the country’s first formal THEM.” medical student leadership curricula. Earlier this year, Alpha Kyle Gibler Omega Alpha recognized the group of Duke medical students the responsible for creating the innovative program with its annual Service Leadership Project Award. One of only three recipients of the award nationwide, Duke will receive $9,000 over three years to support the new LEAD curriculum. The Charge group was led by medical student Kyle Gibler, MSIV, and over the past two years has included team members Marisa Dowling, MSIII; Parastou Fatemi, MSIII; Nimit Lad, T’10, MSIII; Nicole Zelenski, MSIV; Peter Wei, MSIV; Mitchell Bassett, MD’13; and Grant Sutter, MD’13, HS-current. Piloted in the 2012-2013 academic year, the LEAD Program was fully rolled out to first-year students during Student-led the 2013-2014 academic year. Unlike other programs geared curriculum is toward residents or medical students seeking special quali- fications or an additional degree focused on management or a national first, leadership, the LEAD Program is not a separate track and will benefit all Duke medical students regardless of their wins AOA interest or future goals. leadership On the surface, the LEAD Program may not look much different than what students over the past few decades have award experienced. Students will continue to take courses such as the Practice course during the first year and the Capstone course during the fourth year. However, what’s special about LEAD by Bernadette Gillis is that leadership components are more explicitly woven into the existing curriculum’s basic courses, clinical rotations, TODD SUMLIN SUMLIN TODD

22 | DukeMedAlumniNews DukeMedAlumniNews | 23 and during the scholarly research year. task as part of the already-established, monumental changes currently facing the Special workshops, small group activi- yearlong Feagin Scholars Program health care industry. ties, and lectures led by faculty outside named in honor of emeritus faculty “Health care is going to be delivered more of the School of Medicine are highlights member John A. Feagin Jr., MD’61. and more in teams with health profession- LEAD curriculum of LEAD as well. Gibler and the student group worked als working together,” Grochowski says. Colleen O’Connor Grochowski, PhD, closely with Taylor and other faculty “Certainly teamwork is a critical cornerstone 1ST • Workshops on team build- associate dean for curricular affairs, mentors, Saumil Chudgar, MD’05, of leadership, as is knowing when to lead ing and leadership YEAR says leadership has been a fundamental HS’05-’08; and Devdutta Sangvai, MD, and when to follow and how to interact with • Individualized goal setting and monitoring yet implicit part of medical school B’03, to find ways to incorporate leader- others. We have placed an increasing emphasis • Mentorship from 3rd-year training at Duke for years. ship training models from the business on creating opportunities for our students student leaders “Students glean leadership-type world and the military into the world of to learn with their health professions peers experiences through the educational medical education. They also collabo- here at Duke. Incorporating teamwork into a • Lectures and workshops ND program, particularly as it relates to rated with faculty and administrators in leadership curriculum will help enhance our 2 on clinical leadership skills YEAR the third year,” she says. “They have the Duke Fuqua School of Business and medical students’ participation in these types • Individualized goal tracking to be self-motivated, create a proposal, Duke Corporate Education to come up of inter-professional activities both as students and integrate themselves into a working with the LEAD Program. and then as professionals.” • Distinguished Leader RD 3 Series team to do research. It’s sort of implied “Medical students’ schedules are “I think we’ve fallen behind in our profes- YEAR • Mentorship of 1st-year that those experiences will result in already so packed,” Gibler says. “This sion,” Taylor adds. “We need to take active learning teams leadership skills or leadership qualities curriculum wasn’t about adding on leadership roles at all levels.” • Feagin Scholars Program within our graduates, but I always more classes but repurposing them.” While Gibler himself is earning an MBA thought we had an opportunity to do a The group worked to make sure the degree in addition to his medical degree, he • Real-world project in TH little more.” leadership components fit well into both realizes business or management degrees aren’t 4 either hospital or community YEAR Aware of this gap in leadership train- the lecture-based and experiential por- for every student, but that doesn’t mean they setting • Capstone presentation on ing at the medical-student level, along tions of the curriculum and would nat- aren’t cut out for leadership roles. leadership journey with the health care industry’s growing urally build on one another as students “An MBA is clearly a good idea for a certain need for more physician leaders, in progressed through medical school. The subset of students,” he says. “But every student 2011 Dean Taylor, MD’85, HS’87-’91, topics covered include team-building, needs to understand the skills to be an effective Join us communication, self-reflection, leader. The hope is that students will think of and leadership theory for first- themselves as leaders because eventually we’ll as we welcome year and second-year students. all have the opportunity to lead on a daily Third- and fourth-year basis. Traditionally leadership within medicine back reuniting students will have a chance to has been seen as a physician leading a hospital. officially put their new skills in We believe all physicians are leaders.” alumni and kick off practice during a community Although the LEAD curriculum is now service project and while formally part of the school’s curriculum, the the Davison Club’s serving as leadership mentors student leaders had the foresight to include a to first-year students. way to measure the effectiveness of the program 45th Anniversary. Taylor was pleasantly sur- and make improvements along the way. prised at how well the group’s Lad headed up that portion of the curricu- Friday, October 18, 2013 The 2011-2012 Feagin Scholars were the proposal turned out and was lum development project. He and other stu- 5:00-7:00 pm architects of the medical school’s new challenged a group of students to come eagerly accepted by several faculty dents also collaborated with colleagues across Washington Duke Inn curriculum, which focuses on leadership up with a way to change the direction of members, including Grochowski. campus, including researchers in statistics, to training throughout all four years. leadership education. “I was very excited,” Grochowski says create a 25-question assessment survey that “We’ve never really had an identifiable of first hearing the group’s proposal for will be given to students periodically over their program where we’ve taken on that LEAD. “We’ve had this opportunity in four years at Duke. The questions focus on responsibility,” Taylor says. “Every our curriculum, and this was a way we six core values: self-management, teamwork, business school has leadership develop- could address that.” communication, improvement in innovation, ment as part of its curriculum, but it’s It did not take long for other faculty mentorship, and health care acumen. rare in medical schools.” and the advisory deans to buy into As chairman of the Feagin Leadership the idea of the new curriculum as Program at Duke, Taylor assigned the well, particularly considering the 1969~2014

24 | DukeMedAlumniNews CLASS NOTES CLASS NOTES

For a week, Wiley also made multiple in Atlanta. He and his wife, Betty 1940s Peck Dratz, live in Chamblee, MD’32 trips back to the Hammonds’ house from Stanley Karansky, MD’41, is Genius of Wiley, , Ga., and have one daughter, two his office to check on the baby, with working with a writer to create grandchildren, and five great each visit amounting to about 70 miles his memoirs. He has five children grandchildren. He writes, “We Saves One-Pound round trip. with whom he stays in close have an unusual marriage—we When she was 53 years old, long after contact. He also has eight grand- are both happy after 64 years.” Infant—in 1945! she had moved to New York and several children and nine great-grandchil- years after Wiley’s death, Hammonds finally dren, the youngest born on Feb. R. Rodney Howell, MD’57, connected with the family of the man who 19, 2013. HS’57-’60, DC, received the 2013 March of Dimes/Colo- saved her life. With help from a reporter Lloyd F. Timberlake, MD’41, nel Harland Sanders Lifetime at The Cheraw Chronicle in Chesterfield HS’47, after losing two wonderful  Dean McCandless, MD’50, Achievement Award in Genetics. County, Hammonds got in touch with wives, married Lillian Roberts DC, at age 93 still keeps his Howell, a pioneer in newborn Wiley’s daughter, Monnie Bittle, who easily Timberlake on May 24, 2012. It was a cold winter morning on Jan. 9, In Petite Belle: How I Got My home call-bag in the back of screening, is professor of pedi- found Hammonds’ medical chart and Timberlake lives in Atlanta and 1945, in rural Chesterfield County, S.C., Name (AuthorHouse 2012), Ham- his Jeep Liberty, and it came in atrics and chair emeritus of the shared Wiley’s handwritten notes with her. has four children: Lloyd Jr., Anne, when Maggie Hammonds, only six months monds recounts how Wiley saved handy one Sunday recently at his Department of Pediatrics at the Mark, and Susan. pregnant, realized she was in labor. her life using techniques that now Monnie “wrote to me and asked me to church, where the congregation University of Miami Miller School Although her other six children were deliv- sound primitive but were actually call her collect,” Hammonds writes. “I don’t David Hubbell, MD’46, HS’47, knows him as Deacon Doctor of Medicine. Howell played a ered by a midwife, she and her husband, quite advanced for the time. know who was more proud to hear from is professor emeritus of surgery Dean. McCandless served in Eu- key role in the development of rope during World War II, earn- Barnell, knew they needed a doctor. The each other; her or me. Our conversation at the University of South Flor- the uniform panel of serious Hammonds says while growing ing a Silver Star, Bronze Star, and nearest doctor drove more than 30 miles was as if we were long lost relatives.” ida. He and his wife Barbara, disorders for which nearly every up, her mother told her many Purple Heart, and was a family to the Hammonds home. Miraculously, Through Monnie and others who had WC’47, enjoy the blessings of baby in the U.S. is tested. He is a times of Wiley and how he used practice physician and chief of the the baby girl survived, weighing less than been treated by Wiley, Hammonds got life in St. Petersburg. member of the Hussman Institute the wood stove to keep her warm Department of General Practice a pound. further proof that racial segregation played for Human Genomics and has during those critical first few days Gilbert A. Rannick, MD’49, has with the Fontana Medical Group no role in how Wiley treated his patients. served as president of the Amer- Walter R. Wiley, MD’32, the local doc- of her life. been retired from his general in California from 1952 until his In her book Hammonds describes a Mrs. ican College of Genetics and tor and an alumnus of Duke’s first graduat- “My mother told me and surgery practice and position as retirement in 1981. Genomics, and as president of its Evans, who informed her that in Wiley’s clinical professor of surgery at ing medical class, knew his work had only reminded me over and over foundation. He lives in Miami. waiting room, “the black people and Quillen East Tennessee School Dick F. Bedell, T’53, MD’57, and just begun. Regulating the temperature of again that I weighed less than whites waited together in the same room. of Medicine since 1993. He has his wife Jean, N’56, have trav- Luther Sappenfield, MD’57, this tiny baby girl, who fit perfectly in one a pound,” Hammonds writes in RAYMOND JONES JONES RAYMOND eled annually to Mexico and India hand, would be the key to her survival. He He took you by appointment; there was no six children, 11 grandchildren, recently remarried, exchanging her book. “She said my head for the past 30 years, providing wasted no time recreating the safety of the Petite Belle Hammonds credits Walter Wiley, MD, discrimination.” and two great grandchildren. He vows with his new wife Priscilla, was the size of a tangerine with with saving her life at a time when the outlook for medical and faith-based support womb by tightly wrapping her in cotton, Hammonds, who spent most of her ca- lives in Johnson City, Tenn., with two years after losing Nancy, to straight, black hair…. Mama said babies born prematurely was dismal. for individuals living in volatile ar- whom he was wed for 57 years. placing her in a box, and putting her in one reer as a clinical laboratory technologist, is his wife Elizabeth, who he writes I was red and wrinkled. I didn’t “still keeps me honest and as eas. Their work includes helping He volunteers twice a week in the of the warmest places in medicine dropper. Hammonds says the im- currently working on a biography of Wiley. have eyelashes and I had usual helps complete my sentenc- people with HIV and AIDS and surgical section or front desk at the house—inside the age gives her a chuckle, considering she and In addition to exploring more about Wiley a faint amount of eyebrows, no es.” He still shoots his age on the providing conflict management the Pineville branch of the Caroli- food warmer of the fami- her sister used medicine droppers to nurse the man, she hopes to delve deeper into fingernails, and a thin layer of golf course and has done so every workshops. The retired couple’s nas Medical Center in Charlotte, ly’s wood-burning stove. injured birds back to health as children. the field of neonatology, of which Wiley toenails.” year since age 73. service missions have been done and he still enjoys playing golf While doing research for the book, Ham- was a pioneer in Hammonds’ eyes. She says with organizations that include Sylvia Anne was the It wasn’t until she began and spending time at the lake monds learned that Wiley spent the night she is fascinated with learning what it takes Rotary International, Home of name Maggie and Barnell working on the book and talking 1950s house at Lake Tillery. “Life is with her family in their home, keeping close for premature babies to survive, especially Hope, and Project C.U.R.E., the had picked out, but with relatives that she got a better Norman H. Garrett Jr., MD’50, short,” he says, “so enjoy every considering today’s neonatologists use largest collector and distributor of Wiley asked permission to watch over her. Hammonds’ brother Arthur, HS’52-’54, DC, and his wife day as if there is no tomorrow.” idea of the extent of care Wiley equipment that is light years ahead of medical equipment in the world. instead name the miracle whom she calls “Buster,” told her Wiley Becky, N’49, have moved to River provided. Wiley’s wood stove incubator. Dick also volunteers with Meals Donald H. Tucker, MD’58, HS’62, baby for her small size and would sleep at the edge of their parents’ Landing, a retirement village in Not only was Wiley able to fash- on Wheels and serves on the DC, is a member of the Medical beauty: Petite Belle. Wiley bed, tucking Baby Hammonds inside his “I never met him, but I think I know him Colfax, N.C. They have four chil- ion the wood-burning stove into Board of Directors of the Medical Alumni Council at Duke and is shirt while he slept, a technique now com- pretty well,” Hammonds says. “Dr. Wiley dren, 16 grandchildren, and three Such was the beginning Benevolent Foundation (MBF). co-chair of the Class of 1958 an incubator well before the use of monly referred to as the kangaroo method. was a genius.” great-grandchildren. The Garretts of Petite Belle Hammonds’ life. It’s a story The Bedells, who live in Lafayette, Reunion Committee. He founded more sophisticated equipment, but he also But her sister Annie Eugenia insists Wiley enjoy spending time throughout that she loves to tell over and over. She Hammonds, now retired, lives in Colo., plan to volunteer in Haiti Physicians East, a large multi-spe- was aware of the threat of infection. slept on the family’s Davenport loveseat. the year with their family at their has been asked about her name so often Atlanta, Ga. She has one daughter, also with MBF this year. cialty group in Greenville, N.C.; is “He wouldn’t let anyone hold me,” Ham- Still, Hammonds, who is black, says she is house in North Myrtle Beach, over the years that recently she decided born prematurely, weighing 4 lbs., 3 oz. past president of the Pitt County monds says, “not even Mama.” astounded that a white physician would S.C., and their 30-acre farm near Arthur Dratz, T’47 PhD’53, is to write and self-publish a book about her She also has five grandchildren and three Medical Society; and served sleep in the home of a black family at a time Gibsonville, N.C. retired from his position as assis- birth and the doctor responsible for her Wiley had Maggie pump breast milk, great-grandsons. when segregation was the law of the land. tant chief of the nuclear medicine Continued on Page 29 unlikely survival. which he would feed Hammonds using a – Bernadette Gillis service at the VA Medical Center

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Continued from Page 27 MacDougall’s arm was too badly dam- on the Duke Hospital Advisory Mullen and his wife, Patsy Few Robert K. Yowell, MD’61, After 45 years, aged for either the doctors aboard ship Board. He and his wife Barbara Armstrong Mullen, now live in HS’69, DC-Century, and his or at the base in Da Nang to save. He was Lane Tucker, WC’54, live in Newnan, Ga. They have five wife, Barbara Dimmick Yowell, T’56, MD’60, flown to the Philippines and then to the U.S. Greenville and have a remark- children—Donald Collins Jr. N’62, celebrated their 50th Green, Incredibly, within less than 24 hours he was able Duke family legacy: all four T`85, Melissa Mullen Ballan- anniversary on June 30, 2012. in Dayton, Ohio, on Green’s table. of their children—Donald H. tyne, Mary Christina Mullen, They have four children—Rob- Tucker Jr., T’81; Susan Tucker Julie Ann Mullen-Hartman, and ert, T’88, Sally, T’90, Charles, reunites with pilot “It has always amazed me that they were Weaver, T’83; Michael A. Martha Mullen Conroy—and T’92, and Kelly—and seven able to get him from Da Nang to Dayton in Tucker, T’85; and the late Lynn 16 grandchildren. grandchildren, the youngest of whose arm he saved 22 hours,” Green said. “I knew we could Tucker Grogan, T’81—gradu- whom, Kendall Ruby Barbour, save the arm. It was a question of how much ated from Duke, as have three was born on Aug. 27, 2012. The function he would have.” grandchildren. Yowells live in Durham. Over the course of six surgeries, Green re- Leslie C. Norins, MD’62, and paired the massive damage to MacDougall’s As an Air Force surgeon stationed at 1960s his wife Ann “Rainey” have arm. He was able to restore enough motion William W. Fore, MD’60, Wright-Patterson Air Force Base in Dayton, been invited to become Honor- that within a year MacDougall returned to HS’64, and his wife Judy O. Ohio, during the height of the Vietnam ary Members of the Walter and Fore, live in Black Moun- War, Robert Green, T’56, MD’60, saw full flight status. He became a flight instruc- Eliza Hall Institute for Medical tain, NC. He volunteers with a lot of badly injured servicemen cross his tor until he returned to civilian life, earning Research in Melbourne, Austra- ABCCM Medical Ministry. He operating table. But one of them in par- a law degree and practicing aviation law for lia. After receiving his medical writes: “I enjoy having the ticular stuck with him, a wounded young nearly 40 years. degree from Duke, Norins did energy and ability to care Over those years, even as Green won- postdoctoral research at the pilot whose journey from the skies over for some of the uninsured in  David T. Pitkethly MD’61, Hall Institute in the 1960s North Vietnam to Dayton was especially dered what had become of MacDougall, Buncombe County.” DC, and his wife Mara went on and earned a PhD there as a remarkable. For the next 45 years, Green MacDougall wondered what had become of a two-week volunteer mission fellow of the Nobel laureate in often wondered what had ever become the doctor who saved his arm and his career. Philip H. Pearce, MD’60, in March 2013 to the Addis immunology, Sir Macfarlane of Capt. Tom MacDougall, whose right Like Green, he had tried without success to HS’60, ’64-’67, has found it Ababa School of Medicine in Burnet. He and Rainey live in arm was shattered when he ejected from track the other man down. Then, one day in personally rewarding over the Ethiopia, under the auspices of

THOMAS CORDY CORDY THOMAS Naples, Fla., and have returned his crippled F-4 Phantom over the Gulf of 2012 his daughter Caroline, who was doing years to serve as a patient ad- the Foundation for International to Melbourne several times and Tonkin. Years later, Green tried to find Mac- Orthopaedic surgeon Robert Green, T’56, MD’60, repaired multiple fractures and research for a video biography of him for his vocate for family and friends, Education in Neurological Sur- hope to go again. Dougall, but beyond verifying that a pilot nerve damage that Air Force Capt. Tom MacDougall suffered when his plane was family, asked him if he had ever found Dr. especially upon discharge gery. The medical school there shot down over Vietnam in 1967. from the hospital or during by that name had been shot down that day Green. No, he said, he never had. “Well,” has a neurosurgery residency C. Franklin Church, MD’63, evaluation of complex medical in 1967, he got nowhere. she said, “I think I’ve found him.” program with three faculty and HS’64-’66, DC-Century, of problems. He writes, “Medi- tennis champion—was pulled away from “What he did with his 21 residents, and their gradu- Raleigh, is currently a founding Then one day last year the phone rang in By coincidence, the two men now both cine is more complicated than his young wife, their new baby, and the ates will soon be practicing in principal and chief medical Green’s Florida clinic. skills was just phe- live on the Florida coast: Green in Palm ever, and getting into or out of orthopaedic surgery practice he had the smaller cities of the country, officer for IndUShealth, a man- Beach and MacDougall in Port Orange. After the hospital is like a ‘full court “I was with a patient, and a nurse took just opened when he received his draft nomenal. He’s very which has more than 90 million agement company dedicated that initial phone reunion, they and their press.’” He welcomes any of the call,” says Green, who is a prominent notice in June 1966. He was assigned to modest; he keeps say- people. The primary teaching to serving the self-insured and families have gotten together several times, his fellow classmates interested orthopaedic surgeon in his hometown of Wright-Patterson, where he joined a sur- hospital, Black Lion, has 600 under-insured. The company ing, ‘Anybody could and Green and MacDougall told their story in becoming a patient advocate Palm Beach. “She told him she couldn’t gical team that treated an endless proces- beds, including six ICU beds facilitates access to affordable on the “Fox & Friends” cable talk show. to call him for advice at (919) give him my home number or email ad- sion of grievously wounded servicemen. have done it.’ But I and four ventilators for the quality health care in India, 383-9322. entire hospital. Pitkethly writes, dress, but she took his number. She said his MacDougall planned to go into medi- really don’t think so.” “He’s a wonderful man, a very genuine Puerto Rico, and Costa Rica “Equipment of all kinds is in name was Tom MacDougall.” cine himself, but he fell in love with flying person,” MacDougall says of Green. “What Donald Collins Mullen, at Joint Commission approved Tom MacDougall short supply. The neurosurgical and instead joined the Air Force ROTC he did with his skills was just phenomenal. Sr., MD’61, DC-Century, facilities. Church previously Green was stunned. As soon as he was microscope and power drill are He’s very modest; he keeps saying, ‘Anybody embarked on a second career served as founding partner able, he called the number. pilot training program at the University of bones and damaging nerves. He landed on both inoperable, so craniot- could have done it.’ But I really don’t think in missionary and medical work and president of Raleigh Family “We spoke for an hour, and I’m not a Buffalo. On Memorial Day of 1967, during the beach, staggered into the water and omies are done with hand so.” in Vietnam, Greece, Africa, Physicians, founder and chair his second tour of duty in Vietnam, he began to swim, as best he could with one drills and gigli saw blades. The phone person,” Green said. “It was great. I and China, after a 20-year of North Carolina Medical had just completed an attack on a barge useless arm, toward an American destroyer Green brushes off that kind of compli- need for American/European was really flying when I got off the phone. career in cardiac surgery, Management, and as senior suspected of carrying munitions when his ment. But he can’t keep something like teaching standards is acute, and I immediately called my wife and said, he had seen several miles offshore. including serving as associate medical director for MAMSI/ F-4 was hit first by machine gun fire and wonder, and maybe a little pride, out of his those interested in global ‘Guess who just called?’” Somehow he swam for over an hour, professor at Medical College of United Healthcare. He was a then by a missile. voice when he talks about shaking hands medicine can make a huge The two men were drawn into the covering more than a mile, until a skiff Wisconsin. In 1994 he served as founding board member of with MacDougall. contribution in Sub-Saharan war by very different paths. Green, who MacDougall ejected as the burning jet launched by the destroyer found him and African director for Samaritan’s Raleigh Community Hospital, Africa.” Find out more on spun toward the water. As the ejection seat pulled him aboard, dodging fire from a “He has great strength in that arm,” he Purse, a nondenominational now Duke Raleigh Hospital, and earned both his undergraduate and Pitkethly’s blog: blasted him free, his right arm got snagged North Vietnamese boat all the while. says. “He could break your hand.” evangelical Christian missionary is a former president of medical degrees at Duke—where he dtpit10.blogspot.com. in the plane’s cockpit, shattering all three – Dave Hart and physical aid organization. was also an Atlantic Coast Conference Continued on Page 30

28 | DukeMedAlumniNews DukeMedAlumniNews | 29 CLASS NOTES CLASS NOTES Stonnington, MD’92,

Continued from Page 29 is at Home at the

the North Carolina Academy May 31. He will assume the in vision care, performed is an assistant professor of of Family Physicians. He and position of president in 2015. the first LASIK procedure in radiology and division chief Hospital and on the Farm his wife Linda have three The SVS is the largest national the Carolinas and has since of abdominal imaging at the children: Amy Lynn Church, and international vascular performed more than 75,000 University of Kentucky College After riding out Hurricane Katrina with his “Ninety-nine Whether in research or in seeing patients, Ann Clay Church T`91, and surgical organization in the laser vision correction proce- of Medicine in Lexington. family on his Mississippi farm just south you see at Duke among all the professors Macon Church. world, with more than 4,000 dures. He and his wife, Mary of the Gulf Coast, Michael Stonnington the ability to continue working hard and Cheryl Walker-McGill, T’80, members. Perler is the Julius H. Christenbury, MD, HS’84, percent of cattle Norman W. Wetterau, MD’84, HS’84, was promoted MD’92, stood in the middle of 160 acres achieving, and to not get disconcerted by Jacobsen II, M.D. Professor of live in Charlotte. They have MD’67, continues to practice earlier this year to secretary/ of downed trees and debris and thought, things that are out of your control.” Surgery at the Johns Hopkins two children, Joseph, T’08, farmers think family and addiction medicine treasurer at the North Carolina “Why am I out here?” University School of Medicine MD’13, and Lauren, T’11. It was an event way out of his control— in rural upstate New York. Medical Board in Raleigh, N.C. and the chief of the Division Stonnington had dreamed of owning a I’m crazy.” the hurricane—that led to Stonnington’s He is the American Society of Nancy E. Dunlap, MD’81, was She lives in Charlotte. farm since he was a little kid, and in 1998, love of cattle farming. And he couldn’t be of Vascular Surgery and Michael Stonnington Addiction Medicine’s liaison to  Thomas Wise, MD’69, appointed interim dean of the Endovascular Therapy at Johns he had realized that dream, buying 30 acres happier. His cattle farm now comprises 338 is chairman of psychiatry William T. Obremskey, T’84, the Patient-Centered Primary University of Virginia School to start a tree farm, on top of running his acres (www.stonningtonfarm.com/). Hopkins Hospital. He also is MD’88, is chief of ortho- Care Collaborative, where he at Inova Fairfax Hospital, a of Medicine in May. She is ers. “Ninety-nine percent of cattle farmers the senior editor of the Journal paedic trauma at Vanderbilt busy orthopaedics practice. He built the “I don’t play golf. I do orthopaedics, works to provide leadership in satellite campus of Virginia expected to be with the uni- think I’m crazy,” he says. of Vascular Surgery. He and his University Medical Center. He farm gradually, buying surrounding land as integrating behavioral health Commonwealth University and versity for at least 18 months farming, and being a dad. And I love it,” wife Patti live in Ruxton, Md., was promoted to professor of it became available. In 2005, Katrina hit, But after reading and educating himself, into the patient-centered an affiliate of George Wash- as it continues the process of Stonnington says. He runs the farm with and have two children: Mason, orthopaedics last September and the storm was worse than he could he believes that natural and grass-fed is medical home. He is involved ington University. He does his hiring a new executive vice the help of two full-time employees. In a senior at the University of and is involved in U.S. Depart- have imagined. He spent tortuous hours the best way. “Cows are hard-wired to eat with N.Y. State politics, having academic work at both Fairfax president for health affairs. A the summer, his children—17-year-old Virginia, and Rachel, a fresh- ment of Defense research on watching the storm destroy all his barns and grass,” Stonnington says. “We’re fighting helped get a bill passed that and Johns Hopkins, where he search for a permanent dean Henry, 15-year-old Grace, and 13-year-old man at Yale University. severe orthopaedic injuries to send trees hurling through the air. “Any one nature by feeding them grain.” He also keeps those who call 911 for continues to work part time. for the School of Medicine will Christian—work the farm full time. His wife, civilians and the military. He of those trees could have come crashing avoids antibiotics unless necessary and a drug overdose from being His wife Kathy is a volunteer William B. Bunn, T’74, be launched following that ap- Katie, who holds a PhD in materials science is completing a health care through the roof. The house was shaking. It doesn’t use growth hormones. arrested. He also played a role at the Kennedy Center in MD’78, L’78, HS’79-’83, has pointment. A pulmonologist, from North Carolina State University, runs MBA at Vanderbilt and plans in the passing of a law to ex- Washington, D.C. They have been appointed by the World Dunlap is physician-in-res- seemed like it lasted forever,” he says. Stonnington’s love of learning and his the business side of the operation. Ston- on continuing clinical medicine pand drug courts. He has also two daughters: Catherine, an Health Organization as United idence with the National In the aftermath, he felt like giving up. work ethic were both nurtured during nington works the farm at night and all and helping the medical worked to ensure that in the attorney in New York, and States representative to the Governors Association Center Then a logger friend of his showed up to his time at Duke, and he applies them day on weekends. He takes care of most of center navigate health care event of medical marijuana Elizabeth, a first-year resident International Commission for Best Practices in Washing- help clear the rural road where Stonnington to everything he does. “I’m constantly the animals’ medical needs and does many in psychiatry at Johns Hopkins. evolution. His wife Jill, T’86, approval in New York State, on Occupational Health and ton, D.C. She previously held lives; his friend knew the doctor would be reading about the cattle industry and trying other tasks. “I’m fixing pipes and building is director of the Vanderbilt the drug will be administered reappointed to the National numerous appointments at needed at Forest General, the busy trauma to make myself a better farmer, and I do fences and learning how to do all kinds of Pediatric Urgent Care Centers. in a non-smoking manner and 1970s Advisory Committee on Occu- the University of Alabama at referral hospital where he’s a trauma and that with orthopaedics too,” Stonnington things I never knew how to do,” he says. Their children are Allie, a pre- be FDA-approved. Pamela Bowes Davis, pational Safety and Health by Birmingham, most recently says. “That’s what Duke has done for me. med sophomore at University total joint surgeon. (Stonnington is one of – Angela Spivey MD,’74, HS’75, PhD’72, DC, Congress Committee. He is a as professor of medicine and Melvin L. Elson, MD’69, of Southern California; Nick, a the few doctors in Mississippi who can fix is vice president for medical full professor at Northwestern business. HS’71-’73, DC-Century, high school senior and future a broken pelvis.) The cleanup was arduous affairs and dean of the med- University School of Medicine now semi-retired, is teaching Alice M. Ormsby, MD’82, premed, and Analise, a high and expensive, and he decided he would ical school at Case Western and an associate professor at around the world and is pres- recently celebrated her 25th school freshman. The family never run a tree farm again. But his logger Reserve University in Cleve- the University of Illinois. Bunn ident of the American Acade- wedding anniversary with lives in Nashville. friend raised and sold cattle on the side, land, Ohio. In March 2013, has retired as vice president my of Aesthetic Medicine. In her husband, Robert G. and Stonnington began partnering with him Davis married James Patrick of health, safety, security, J. Alan Wolfe, MD’84, was 1999, he and his wife Betty Freid. They are the proud on a few cows. He did that for two or three Herget, an independent exec- and productivity at Navistar, one of two cardiovascular established the Melvin L. and parents of 15-year-old twins; years, then went out on his own. utive search consultant. The Inc., where he is now an surgeons to perform the first Betty M. Elson Scholarship daughter Abigail is passionate New York Times reported that advisor-consultant. U.S. implant of eSVS Mesh, At first he raised his cattle the main- Endowment at Duke University about musical theater and the couple, who met in 2008, a new technology that could stream way, taking them to commercial School of Medicine. His third is her school’s student body decided to marry after Herget improve the quality of life feedlots once they reached a certain weight book, Skin Scam: Dying to Be 1980s president, and son Spencer is supported Davis through Jonathan Christenbury, for patients who need heart to be “finished” and sold. But now and Beautiful, is available on Am- an expert in exotic cars and breast cancer and chemother- MD’81, HS’81, ’85, DC, bypass surgery. The implant again he would get a notice that his cow azon.com and as an e-book. It actively follows the stock apy, and they discovered that was featured on “In View,” was performed at Northeast had died at the feedlot. “I don’t have cows details the issues patients face market. The family lives in for all intents and purposes, an educational television Georgia Medical Center in that routinely die on the farm,” Stonning- when looking for qualified Woodinville, Wash. they were “already married.” program hosted by Larry King February 2013 as part of an doctors to perform procedures ton says. “Why are they dying? They were on the Discovery Channel. The Scott D. Stevens, MD’83, initial feasibility clinical trial to reverse the signs of aging. Bruce A. Perler, AB’72, healthy when I sent them out there.” show included a five-minute was inducted as a Fellow in approved by the FDA. Other MD’76, was elected vice-pres- That’s when he started reading about segment about laser eye sur- the American College of Ra- cardiac surgery centers in the ident of the Society for the “farm-to-table” movement and feeding gery at the Christenbury Eye diology (ACR) during the ACR U.S. will join the clinical trial. Vascular Surgery (SVS) during cows grass instead of grain. He decided to th Center, which he established Annual Meeting and Chapter Wolfe, who practices with

the 67 Vascular Annual process the cows himself, and rather than OLIVIER RICK in 1987. Christenbury, known Leadership Conference in Meeting in San Francisco on Continued on Page 32 use feedlots, sell only to individual consum- for his groundbreaking work Washington, D.C., in May. He Katie, Michael, Christian, Henry, and Grace Stonnington on their cattle farm.

30 | DukeMedAlumniNews DukeMedAlumniNews | 31 CLASS NOTES HOUSE STAFF

Continued from Page 30 Northeast Georgia Physi- dic Sports Medicine), the larg- leading a curriculum redesign, 1960s Richard H. Daffner, MD, HS’70- fessor of environmental and Duke. In 2013, Dr. Nunley at the National Institutes of cians Group Cardiovascular est international orthopaedic teaching, conducting HIV/TB ’73, gave the commencement occupational health at the GW was the Presidential Invited Health in Bethesda, Md., was and Thoracic Surgeons in sports medicine society, with immunology research, and address at his alma mater, Al- School of Public Health. Guest of the Royal Thailand struck by how much easier it Gainesville, Ga., also has more than 4,000 members in seeing patients with HIV in his bany College of Pharmacy and Orthopaedic Society, the is for people to say they have developed his own technique 92 countries. Safran and his position as associate professor Health Sciences, in celebration E. Ruffin Franklin, MD, T’69, Chilean Orthopaedic Society, a physical illness than it is to of minimally invasive heart wife, Lee Shelbourne Safran, of medicine at the newly of the 50th anniversary of his HS’75-’76, senior partner for and the Russian Orthopaedic admit they feel out of control valve reconstructions. T’88, reside in Stanford, Calif. renamed Geisel School of graduation. Also, the fourth Capitol Pediatrics & Ado- and Traumatology Society. His with an emotion such as fear, Medicine at Dartmouth. His edition of his textbook, Clini- lescent Center, says that his son Ryan Nunley, MD, is an anger, or depression. He wrote wife Jessica just earned a cal Radiology: the Essentials, practice, with three offices in assistant professor of Ortho- the book to help people un- book deal with Harper is scheduled to be published in Raleigh and Wake County, is paedic surgery at Washington derstand the roots of human Publishing, so Tim says he is September 2013. joining the Private Diagnostic University in St. Louis, and his behaviors and feelings. He “considering early retirement  Douglas P. Zipes, MD, Clinic Division at Duke Medical son Jefferson Nunley, DVM, is lives in Potomac, Md.  Clarence M. Findley, to live large with sons Ben, 2010s HS’64-’68, has become M. Bruce Shields, HS’74, retired Center on October 1, 2013. completing a surgical residen- MD’09, PhD’09, and Hewan Charles R. Author III, MD’10, 14, and Finn, 9, amid the interested in writing fiction, in June 2011 from Yale Univer- Capitol Pediatrics will be the cy at Animal Medical Center in Maryella D. Sirmon, HS’85, is Bekele Findley, T’02, were was appointed chief resident Laheys’ alarmingly populous after having published many sity, where he was chair of the first private pediatric specialty New York. a partner with Nephrology married on March 23, 2013, in during his psychiatry residency backyard menagerie.” medical articles and textbooks. Department of Ophthalmology practice to join Duke’s PDC. Associates of Mobile, Ala., Raleigh. Since 2011, they have at Johns Hopkins Hospital, in “Although my dissenters might and Visual Science. Prior to Other Duke-trained pediatri- and a clinical adjunct faculty Wendalyn King Little, been living and working in the academic year 2013-2014. 1980s say that I’ve been publishing taking his position at Yale in cians in the group are Jeffrey member at the South Alabama  Tina S. Alster, BSN’81, MD’98, is on the pediatric San Francisco Bay Area. Clar- Claude A. Piantadosi, MD, They have three children, fiction all along!” he writes. 1996, he served for 25 years Ryan, MD, HS’94-‘97; Wendy College of Medicine. She is emergency medicine faculty ence is continuing cardiology MD’86, is director of the Janna, Nathan, and Clark. He adds that former U.S. pres- HS’80-’81, has published Man- training at Stanford University at the Duke Eye Center. He Taylor Book, MD‘99; HS’99-’02, past Governor of the Alabama Washington Institute of at Emory University in Atlanta ident Bill Clinton and Israel’s kind Beyond Earth: The Histo- and his wife are now back in and Jacqueline Farber Kerkow, Chapter of the American James Fang, MD’88, has and recently assumed the with plans to pursue advanced ry, Science, and Future of Hu- Dermatologic Laser Surgery, president Shimon Peres are North Carolina, where he does College of Physicians. She been named chief of car- position of director of the training in interventional MD, HS ’09-‘12. man Space Exploration (2013: which she founded in 1990. reading his two novels, Ripples volunteer work, including and her husband Wayne live diovascular medicine at the Pediatric Emergency Medicine cardiology. Hewan works Columbia University Press). She is also a clinical professor in Opperman’s Pond and The working with Duke residents in Mobile, Ala., and have two University of Utah School of Fellowship Program. She as a senior manager in the Russel Kaufman, MD, HS’73- The book seeks to “re-ener- of dermatology at George- Black Widows. The Black at the Durham VA Hospital. grown children. Delivery System Planning ’78, was presented with the town University. She has Medicine and director of the and her husband Larry live Widows is about a terrorist cell gize Americans’ passion for Department for Kaiser Per- Greater Philadelphia Life Sci- established two scholarship cardiovascular service line in Atlanta with their three and takes place in Chappaqua, the space program, the value manente Northern California. ence Congress’ “The Ultimate endowments at Duke for at University of Utah Health children and enjoy running, N.Y., where the Clintons of further exploration of the The couple spent a few days Solution” award for his lead- women pursuing a career in Care. Fang, who specializes hiking, and camping when live. Zipes is a distinguished Moon, and the importance vacationing in Costa Rica after ership as chair for the past medicine, and she recently in treatment of patients with busy schedules allow. professor at Indiana University of human beings on the final their wedding but had plans  E. Philip Lehman, three years. The Life Science hired two other Blue Devils heart failure, previously held School of Medicine. frontier.” He is a professor of (Terrence Keaney, BS’02, MD the Spitz Master Clinician 2000s to honeymoon in Venice, the MD’10, MPP’10, and wife Congress is a component of pulmonary, allergy, and critical and Tania Peters, MD Chair at Case Western Greek Isles, Istanbul, and Emily welcomed a daughter,  James A. Paulson, MD’75, the Philadelphia Convention care medicine and director of HS’08-’11). In addition, Alster Reserve University School of Dubai in late summer 2013. Anna Giles Lehman, on May 1970s recently met with the First and Visitors Bureau. Kaufman the F.G. Hall Environmental Medicine in Cleveland, Ohio, 15, 2013. Anna weighed 6 Wayne B. Venters, MD, HS’68- Lady of Tanzania and the lead- is president and CEO of the and Keaney in February 2013 Krish Patel, T’05, MD’09, Laboratory at Duke. where he was a professor of pounds, 10 ounces and was ’72, retired from orthopaedic ership of the Paediatric Asso- Wistar Institute, an indepen- Launched W for Men, the will serve as chief resident in medicine and associate chief 19¼ inches long. Lehman cur- surgery in July 2013 after 41 ciation of Tanzania to develop dent, non-profit biomedical world’s first center focused internal medicine for the Duke of clinical affairs for cardio- rently is an internal medicine years of practice. He spent a long-range plan to increase research center in Philadel-  Jorge Gamba, MD, HS’82- exclusively on the skin care Internal Medicine Residency vascular medicine. resident at Duke. 29 years in his own practice the capacity of Tanzania to phia. He also recently received ’86, is a neuroradiologist and needs of men, which was Program, with a faculty in his hometown of Jackson- assess, manage, and prevent the Philadelphia Business senior partner with Mori, Bean, featured in Town and Country. appointment as medical ville, N.C., where he was the environmental health threats Journal Life Sciences CEO of & Brooks, P.A. in Jacksonville, 1990s instructor from July 2013 to Marc Safran, MD’87, is a town’s first orthopaedist. In to children. Paulson, of Alex- the Year award. He and his Fla. He and his wife Ann have July 2014. After that, he will professor of orthopaedic 2001, he moved to Spokane, andria, Va., met the First Lady, wife Jane live in Philadelphia two children, Thomas Jorge complete his final two fellow- surgery and team physician Wash., and joined Rockwood H.E. Salama Kikwete, when and have two children, Jona- ship years in hematology and Gamba, T`10, and Christina at Stanford University, where Multispecialty Clinic as an she toured the Children’s Na- than and Emily.  Trisha Voeltz Fleshman, oncology at Duke. Gamba. Christina was born at he is also the fellowship tional Medical Center, where DPT’08, married Justin Flesh- ortho-hand surgeon. He now Duke Medical Center in 1988 director and associate director he is the medical director for man on December 7, 2013. plans to continue to hold James A. Nunley, T’69, HS’75- during Gamba’s radiology res- of sports medicine. He was national and global affairs of She is director of physical ther- musculoskeletal lectures and ’79, recently stepped down idency. She recently graduated recently elected 2nd vice pres- the Child Health Advocacy  Ted George, MD, HS’80- apy at Integrated Sports Medi- clinics with the Providence as chairman of the Ortho- from Stanford Medical School. ident of ISAKOS (the Interna- Institute and the director of 83, has published a book, cine and Physical Therapy, and Internal Medicine Residency paedic Department at Duke In the photo above: Dr. Gamba tional Society of Arthroscopy, the Mid-Atlantic Center for Untangling the Mind: Why We he is a project manager. They Program. He also hopes to University, a position he held celebrates with Christina at her Knee Surgery, and Orthopae-  Tim Lahey, MD’98, Children’s Health and the Behave the Way We Do, to live in Springfield, Va. spend time fishing and work- for the last 11 years. He con- Stanford graduation ceremony. announces that he “finally lost ing on his photography hobby. Environment. Paulson is also a tinues to teach and perform help readers understand what all of his hair.” He is distracted professor of pediatrics at the research as the J. Leonard happens within the brain, and from that development by George Washington University Goldner Endowed Professor why. George, a psychiatrist School of Medicine and a pro- of Orthopaedic Surgery at and associate clinical director

32 | DukeMedAlumniNews DukeMedAlumniNews | 33 HOUSE STAFF OBITUARIES

Augustine M. K. Choi, MD, ing hospital that provides care husband, Robert Gerstmyer, at Smith College in Northamp- Full obituaries can be found on the Medical Alumni Association web site HS’87, was appointed chair of for the estimated 30,000 chil- PhD’95. They have two chil- ton, Mass., and Tyler was a at medalumni.duke.edu. Please click on the magazine cover, then click the Department of Medicine at dren who live or work on the dren, Anna and Heidi. three-time girl’s soccer MVP at on obituaries. Weill Cornell Medical College streets of La Paz, as well as Newman High School and will and physician-in-chief at New orphans, vulnerable children, join the women’s soccer team Steven H. Boswell, MD, HS’70-’73, of San Antonio, Texas, died his colleagues performed Washington University's first open-heart sur- York-Presbyterian Hospital/ and the impoverished. He is 1990s at Sewanee University this fall. July 8, 2013. He was 70. Boswell served in the U.S. Navy, stationed at gery. He was a founding member of the Society of Thoracic Surgeons Weill Cornell Medical Center. using his masters in leadership Bethesda Naval Hospital in Maryland. In 1976, he moved to San Anto- and served as president of that organization as well as the American training to change the culture Previously, Choi was the nio, where he worked as a radiologist for many years. Association for Thoracic Surgery. In 2009, he received the Lifetime Parker B. Francis Professor of of the hospital and develop Achievement Award from the American Association for Thoracic Medicine at Harvard Medical the capacity of the 80 health Charles L. Brock, MD’54, of Daytona Beach, Fla., died July 12, Surgery. School and chief of Pulmonary care leaders there. He is 2013. He practiced ophthalmology in Daytona Beach for 42 years. His and Critical Care Medicine helping to develop a for-profit  Jennifer Cohen Takagishi, undergraduate studies at Duke were interrupted for active duty service David B. Hill, MD’57, died February 26, 2013, at his home in Lynch- at Brigham and Women’s ambulatory clinic similar to HS’93-96, was promoted to as an officer in the United States Navy during World War II, serving on burg, Va. He was 85. Hill practiced general, thoracic, and vascular Hospital in Boston. In his new the urgent care centers at professor in the Department anti-submarine warfare duty in the Atlantic Ocean. Dr. Brock served on surgery in Lynchburg for 42 years before retiring in 2004. He was role, Choi leads one of the Duke, to provide health care the staff of Halifax Medical Center for many years, including serving as instrumental in developing the intensive care unit at Virginia Baptist of Pediatrics at the University most comprehensive academic for those who now leave the chief of ophthalmology. He was the Florida State Medical Advisor of Hospital and in bringing laparoscopic surgery to Lynchburg. His in-  Chung-Ping Hsu, MD, of South Florida Morsani and clinical departments in country to obtain basic health the National Society for the Prevention of Blindness, an Eagle Scout, volvement with the Lynchburg Academy of Medicine included serving HS’93-94, was promoted to College of Medicine in August the nation, comprising 16 care, to reduce the need for  and a lifelong volunteer with the Boy Scouts of America. on the organization’s board and various committees and as vice presi- Dean Scott Edell, MD, MPH, chair of the Surgical Depart- 2013. She is a member of the dent and president. divisions and more than 1,700 emergency care, and to gener- HS’90-’93, was recently named General Pediatrics Division ment Taichung Veterans Gen- John L. Capps, MD’85, died March 11, 2013, at his home in Gasto- faculty members, physicians, ate revenue for the charitable section head of the Division and medical director for eral Hospital in January 2013. nia, N.C. He was 53. Capps served the Gaston County community for Edwin R. Hudson, MD, HS’92-’94, died of trauma sustained in a and researchers focused on mission of the hospital. He of Pediatric Pulmonary at HealthPark Pediatrics, the Hsu, professor of surgery at more than 20 years in the practice of internal medicine and more re- bicycling accident in Columbia, S.C., on June 11, 2013. He was 61. Dr. clinical care, research, and has also helped coordinate Children’s Hospital of New outpatient pediatric clinic at National Yang-Ming University cently, in bariatric medicine in Rock Hill, S.C. He served on the boards Hudson lived in Columbia for 15 years and was on staff at Palmetto medical education. He and the creation of Bolivia’s first Orleans and director of respi- Tampa General Hospital. She School of Medicine in Taipei, for Gaston County Department of Social Services and House of Mercy Richland Hospital from 1997-2006 and Lexington Medical Center from his wife, Mary E. Choi, HS’87, trauma registry and facilitated ratory care. He is currently a Taiwan, served seven years as also serves as medical director in Belmont. 2006 until the time of his death. live in Boston. They have two health care education with clinical professor of pediatrics chief of thoracic surgery at the for the county Medical Foster sons, Justin and Alex. several faculty from Duke and at Louisiana State University same hospital. He and his wife Care Program and assis- William C. Collins, HS’69, died of complications from pneumonia Dennis E. Ose, PhD’78, MD’79, a pathologist and former Wake other institutions. The Broyles’ School of Medicine and at Tu- Flora live in Taichung, Taiwan tant director for the county on February 25, 2013, at his home in Sandy Springs, Ga. He was 75. County medical examiner, died June 26, 2013, at his home in Cary. He oldest daughter, Candice, is lane University School of Med- and have three children: Children’s Medical Services Collins opened his orthopaedic practice, Northside Orthopedic Clinic, was 64. He previously was in practice in Georgia and Pennsylvania. teaching in Athens, Ga., and icine. He recently finished a Langer, Thomas, and Sharon. program, which provides in Sandy Springs in 1970, becoming one of the first orthopaedists in was married last year. Their five-year stint on the American nurse care coordination and Sandy Springs and at Northside Hospital. He held leadership positions Ernest T. Poole, MD’61, of Wilmington, N.C., died July 8, 2013. He younger daughter, Brianne, College of Chest Physicians’ clinics for children with special in numerous organizations, including serving as president of the Med- was 77. Born in Nashville, N.C., and raised in Raleigh, he earned an un- spent a gap year with her Pediatric Pulmonary Steering health care needs. She and ical Association of Georgia. He also was involved in the formation and dergraduate degree at North Carolina State University. After earning a parents in Bolivia and is now Committee, which sets policy her husband Curtis, PhD, growth of MAG Mutual Insurance Company. medical degree at Duke he was a physician in the U.S. Army, and then studying nursing in Atlanta. for the organization. He and live in Tampa and have two established an ophthalmology practice in Wilmington. his wife Debra have been daughters: Alexandra, 12, and Thomas M. Constantine, T’50, MD’54, an internal medicine and Debra Schwinn, MD, HS’86-’89, residents of New Orleans since Sabrina, 10. hematology physician in Jacksonville, Fla., died March 12, 2013, at age Shaler S. Roberts, MD, HS’58, of Killen, Ala., died March 7, 2013, at in November 2012 started a he completed his fellowship 84. Dr. Constantine’s undergraduate degree at Duke was in chemistry. Eliza Coffee Memorial Hospital in Florence, Ala. He was 85. Dr. Roberts new job as dean of the Roy J. at Duke. Their son Justin He practiced in Jacksonville at the Riverside Clinic for many years. was a board-certified ophthalmologist at the Florence Clinic from 1959  William Broyles, MD, HS’86- and Lucilla A. Carver College (pictured) recently graduated until his retirement in 1993. He also served on the First National Bank ‘89, MHS’03, and his wife of Medicine and professor of from the United States Military John S. Davis, MD’81, of Akron, Ohio, an ophthalmologist who spe- of Florence Board of Directors and the Florence Housing Authority Noelle have been in La Paz, anesthesiology, pharmacol- Academy at West Point with cialized in adult and pediatric strabismus, died April 17, 2013. He was Board of Commissioners and as ECM Hospital chief of staff. Bolivia for almost two years, ogy, and biochemistry at the a major in mechanical engi- 58. After earning a medical degree at Duke, he completed residency working with Hospital Arco and fellowship training at Baylor University in pediatric ophthalmology. Stephen G. Romeo, MD, HS’67-’70, died at his Tolland, Conn., home University of Iowa. She lives neering. They also have two Iris, a 100-bed charity teach- He served as a board certification examiner on the American Board of on March 13, 2013. He was 76. Before training at Duke, Dr. Romeo in Iowa City, Iowa with her daughters. Kendall is a junior Ophthalmology. served in the U.S. Air Force from 1965-1967 at RAF Alconbury Base in England. In 1970, he opened a dermatology practice in Manches- Bruce W. Fischberg, MD’59, a psychiatrist from West Newton, ter, Conn., where he practiced until retiring in 2000. His career also Mass., died May 25, 2013. He was 82. Fischberg served as assistant included mentoring family practice residents at the University of Con- clinical professor at Harvard Medical School, and over the course of his necticut School of Medicine. He was a member of several dermatology career, he held hospital appointments at McLean, Massachusetts Gen- societies, including the American Academy of Dermatology and had eral, and others. He had a private psychiatry practice from 1964-2011. served as president of the Dermatology Section of the Connecticut State Medical Society. Thomas B. Ferguson, T’47, MD’47, HS’47-’50, a pioneer in heart surgery and professor emeritus of cardiothoracic surgery at Wash- ington University School of Medicine in St. Louis, died May 26, 2013, at the age of 90. He played an important role in bringing the first heart-lung machine to St. Louis in the late 1950s, and in 1958, he and

34 | DukeMedAlumniNews DukeMedAlumniNews | 35 OBITUARIES

PLANNED GIVING

Edgar J. Sanford, T’62, MD’65, HS’69-’72, DC, of Tampa, Fla., died Kim M. Walsh, MD’87, HS’88-’91, of Chapel Hill, died April 23, Putting Primary Care First June 26, 2013. He was 72. After serving an internship and one year 2013. She was 53. Dr. Walsh served as medical director of Alamance of training in general surgery at the New York Hospital Cornell Weill and then Durham County Health Departments between 1991 and Medical Center, he entered the U.S. Navy and served from 1967-1969. 2001. Most recently, she served as medical director at Blue Cross-Blue He completed residency training at Duke in his surgical specialty of Shield of North Carolina in Chapel Hill. She earned degrees at Dart- urology. He served on the faculty of Penn State University’s Hershey mouth College, Duke University School of Medicine, and the University Medical Center from 1972-1979, then entered into private urology of North Carolina School of Public Health. Richard Frost, MD’ 73, has learned to practice in Elmira, N.Y. He later returned to academic medicine at the avoid certain topics with his wife Marty, an University of South Florida Medical Center at Tampa until he retired. Antronette ‘Toni’ Yancey, MD’83, HS’83-’84, who devoted her ca- alumna of the University of Kentucky, when reer to improving health and fitness and eliminating health disparities, basketball season rolls around. “I still can’t Leonard H. Schuyler, MD’50, DC-Charter, of Poughkeepsie, N.Y., an especially for vulnerable populations, died April 23, 2013, following a say Christian Laettner’s name around here attending physician at New York Presbyterian Hospital in New York City battle with lung cancer. She was 55. She was a professor at the Uni- without causing trouble,” says Frost, who for over 50 years, died May 10, 2013. He was 96. Dr. Schuyler served in versity of California-Los Angeles Fielding School of Public Health, and the U.S. Army-Duke 65th General Hospital during World War II. was widely known for creating "Instant Recess," a unique program recently retired after practicing medicine for dedicated to "making America healthier 10 minutes at a time." She nearly 40 years in Plattsburgh, N.Y. But if Trudy Small, MD, HS’80-’81, a pediatric hematologist at Memorial earned numerous awards, including the 2012 Pioneering Innovation they have their differences on the hardwood, Sloan-Kettering Cancer Center in New York, died June 14, 2013. Dr. Award from the U.S. Centers for Disease Control and Prevention, the Frosts are in wholehearted agreement Small made important contributions in the development of improved and was one of a handful of national thought leaders asked to serve about their support for the Duke University transplantation approaches for the treatment of patients with ad- on the board of directors of the Partnership for a Healthier America, School of Medicine. vanced leukemia and children with life-threatening genetic disorders of the non-profit that guided first lady Michelle Obama's “Let's Move” the immune system. She first joined Memorial Sloan-Kettering in 1987, campaign. “Duke is well known, of course, for producing and among her many accomplishments, her work provided evidence top-flight specialists, researchers, and academ- critical to the development of the National Centers for Disease Control Barbara Clark Ziko, MD’80, of Raleigh, who practiced emergency ic leaders, and we’re very proud of that,” Frost and Prevention guidelines for vaccination of immune-compromised medicine at several Triangle hospitals, then became a staff physi- transplant recipients. cian with North Carolina State University Student Health, where she said. “But nationally there is a profound need worked for 19 years, died July 5, 2013. She was 60. In high school in for primary care physicians. When we learned Richard C. Stone, T’58, MD’62, HS’62-’66, of Las Vegas, died May Dearborn, Mich., she was one of two Michigan Presidential Scholars. that Duke was making a commitment to 7, 2013. He was 79. At Duke, he was a member of the Alpha Omega Dr. Ziko earned an undergraduate degree in molecular biophysics and primary care, we decided to put our support Alpha Medical Honors Society and won many scholastic awards for biochemistry at Yale University, and a medical degree at Duke. She behind that effort.” achievement. He served in the U.S. Army for four years and served completed an internship in internal medicine at Maine Medical Center. an additional four years in the Army Reserves. In 1965, he joined the The Frosts are giving back to Duke with a Dallas Medical & Surgical Clinic, where he practiced gastroenterology flexible gift annuity that pays them income for 26 years before moving to Las Vegas. throughout their lifetimes, with the balance going to Duke after they pass. Duke offers several plans that give you the opportunity to combine lifetime income, tax benefits, and philanthropy that makes a difference.

PLANNED GIVING To learn more, please contact: Joseph W. Tynan, JD Executive Director of Gift and Endowment Planning 919-385-3114 or [email protected] LES TODD DAVID SEAVER

36 | DukeMedAlumniNews Non-Profit Org. US Postage PAID Durham, NC Duke Medical Alumni Association Development and Alumni Affairs Permit No. 60 512 S. Mangum Street, Suite 400 Durham, NC 27701

2013 LARGEST EVER MEDICAL CLASS

size of the Fall 2013 113 entering medical class

34 # of states represented 28 # of Duke undergraduates underrepresented 23 % minority groups in Primary Care 7 Leadership Track

8 MD/PhD candidates

The incoming class of 2013 celebrates after receiving their white coats.