• FROM THE DEAN ColumbiaMedicine Chairman, Editorial Board Thomas Q. Morris, MD Alumni Professor Emeritus of Clinical Medicine Dear Readers, Editor Bonita Eaton Enochs Dean Lee Goldman has graciously allowed me to fill in for him for this issue Science Editor that is dedicated, in large part, to the medical school’s 250th anniversary. I Susan Conova have been affiliated with P&S for more than 60 years (I arrived on campus Editorial Assistants in 1954 as a first-year medical student and, except for military service, have Avichai Assouline, Odelia Ghodsizadeh remained a faculty member and alumnus since), so Contributing Writers Avichai Assouline Elizabeth Chute longevity itself may make me a part of the history of this Jeff Ballinger Sharon Tregaskis school. I owe some of my affinity for this school’s history Alumni News Editor to my late colleague and friend Don Tapley, who was Marianne Wolff, MD dean from 1973 to 1984. Though not a P&S graduate, Alumni Writer Peter Wortsman Don had respect for the historical eminence of P&S and Design and Art Direction its traditions. As a member of the 250th anniversary Eson Chan steering committee, I have tried to put my historical Editorial Board interests and knowledge to good use. Alex Bandin, MD Stephen Nicholas, MD As you read the historically themed feature articles Jessica Buesing’18 Stephen E. Novak Nicole Curatola’18 Carmen Ortiz-Neu, MD in this issue and offer feedback about your memories Ron Drusin, MD Ajay Padaki, MD of P&S, consider the singular accomplishments of our Kenneth Forde, MD Richard Polin, MD Bruce Forester, MD Donald Quest, MD alumni and faculty. They fill nearly every decade since the school opened in Benjamin French’17 Alan Schechter, MD 1767 and granted the first MD degree in the Colonies three years later. Oscar Garfein, MD John Schullinger, MD Sankar Ghosh, PhD Elyse Seidner-Joseph, MD The 2017 wall calendar produced and distributed with our Fall/Winter 2016 Lee Goldman, MD Joseph Tenenbaum, MD issue showed us how difficult it is to narrow down worthy P&S achievements Tom Hickernell, MD Emily Vail, MD Jay Lefkowitch, MD Robert Zilinyi’17 and individuals. Lisa Mellman, MD Unfortunately, we have few records from much of the 19th century; Columbia Medicine is published twice a year for alumni, fortunately, many of the greatest accomplishments in modern medicine faculty, students, and other supporters of the College of Physicians & Surgeons. It is published by the college and attributed to Columbia happened in the 20th century, resulting in Nobel the P&S Alumni Association through the P&S Office of Prizes to 21 P&S faculty members, former faculty members, and alumni, Communications. Additional content can be found in the online edition at columbiamedicinemagazine.org. including Dickinson Richards’23, André Cournand, Baruch Blumberg’51, Lee Goldman, MD Harold Varmus’66, E. Donnall Thomas, Eric Kandel, Richard Axel, and Robert Executive Vice President for Health and Biomedical Sciences Lefkowitz’66. These accomplishments lend credibility to our anniversary and Dean of the Faculties of Health Sciences and Medicine theme, “We don’t just practice medicine. We change it.” The 21st century is Catherine Freeland off to a good start through the remarkable leadership of Lee Goldman, who Associate Vice Dean Marketing and Strategic Communications worked closely with department chairs and faculty to identify the sacrifices College of Physicians & Surgeons and contributions needed to make the past 11 years successful. Address correspondence to: Some of what we cannot fit into this issue will appear in the Fall/Winter 2017 Bonita Eaton Enochs, Editor Columbia Medicine issue. If that is not enough to satisfy your history appetite, the anniversary College of Physicians & Surgeons website at ps.columbia.edu/250 has historical information that augments what 630 W. 168th St., Box 153 New York, NY 10032 we have room to publish on these pages. 212-305-3900 Email: [email protected] With best wishes, Join the medical school’s Facebook page at www.facebook.com/columbiaps

Alumni should update their addresses by writing the Alumni Association at the address above or calling the alumni office at 212-305-3498. Faculty and staff should contact their departmental Thomas Q. Morris’58 administrators to update their addresses, which are obtained Alumni Professor Emeritus of Clinical Medicine through the Columbia University personnel system. Chairman, Columbia Medicine Editorial Board All others with address changes should contact P&S Communications at 212-305-3900. Vol. 37 No. 1 Spring/Summer 2017 in thisIssue departments features 10 P&S History: Lee Goldman, Dean No. 23 The P&S pillars of excellence— research, education, clinical care, and community service—have been strengthened and polished during the past 11 years through collaborations among leadership, faculty, staff, students, and hospital partners. The blueprint 3 for excellence drawn during the past decade provides a plan for continued success. 2 Letters

3 P&S News

8 Clinical Advances • Management of Pulmonary Arterial Hypertension • Keeping Children’s Digestive 20 Health on Track P&S History: The Quiz Edition • Children Undergoing Heart Surgery at Columbia Have Lowest Mortality The 250 years since Columbia’s in New York State medical school opened have yielded Pulitzer Prize winners, 27 Alumni News & Notes Nobel laureates, medical pioneers depicted on postage stamps, • Profile: Fadlo R. Khuri’89 Olympians, NIH leaders, and many others who have left their mark on 36 In Memoriam medical history. How well do you Faculty and alumni who have died know P&S history?

COVER ILLUSTRATION BY BEN JOHNSTON. This cover is the first of three commemorative covers planned for this year's two issues and the annual report. This cover is intended to honor the school’s Colonial origins. Content about P&S history begins on Page 10. PS& letters

Remembering the ’Hood What I personally remember best was his ability to convert the prob- I hope “the neighborhood” (“Pre- lem of an ordinary patient suffering an ordinary disease into the world’s Orientation Program Welcomes most fascinating set of cardiovascular and renal interactions. Others have Students to the Neighborhood,” pointed out Dr. Loeb’s often frustrated attempts to include students in P&S News, Fall/Winter 2016 the discussion (not banter) of his rounds. In retrospect I’m confident he issue) includes going north, to was attempting (often vainly) to light up some intellectual curiosity in us. include Fort Washington, Fort More than once I remember him (referring to our attempt at reasonable Tryon and Fort George, all therapy that did not “work”) asking, “Funny thing! Eh, Lindberg, funny important in the Revolutionary thing?” What he meant was, how imperfect is our understanding of our War. Fort Tryon Park also con- craft, and (I thought) how much we needed a few experiments. More tains the Cloisters, a branch of than once he would enter so fully into his dialectic that he would smile the Metropolitan Museum of straight at us and commit that sin he never pardoned in others: He would Art, which has wonderful medieval art, including the famous Unicorn rest his foot on the patient’s bed rail. If it is true he was looking for intel- Tapestries, and Gregorian chants on Sunday afternoons. lectual curiosity in us med students—even house staff—no wonder he Charles Brill’61 might occasionally lose his temper. Philadelphia Dr. Loeb ended his practice (under retirement rules one can lament) more or less on the cusp of very great changes in medicine. For example, Faculty Mentors recall his insistence on a rigorous defense of each new lab test ordered: I still look occasionally at the Spring/Summer 2016 issue of Columbia What will you do if it’s high? What if low? etc. This scholarly reasoning Medicine. Items in that issue of great interest to me were the sketches of was (in retrospect) out of tune with the coming of multichannel electro- important women of my time at P&S in 1938-42 (“Women—Long Denied lyte machines, very multichannel autoanalyzers, multiphasic screening, a Role at P&S—Helped Shape Medicine in the 20th Century”). The most and now genomewide analyses. But his thinking was exactly in line with immediate connection was to Abbie Ingalls, an outstanding member of our modern computer-assisted medical decision making. class who charmed us all. My remembrance of her ability and personality Of course, Dr. Loeb could be personally kind too. He once took the was one of the reasons I urged my daughter to select Bryn Mawr College. trouble to discuss with my wife if I should seek an internship on his ser- I had some memorable instruction in pathology from Virginia Knee- vice. Many a time I have thought about the fun this might have been. land Frantz and put a patient to sleep under the personal guidance of Dr. Don Lindberg’58 Apgar. As I shortly thereafter came into pediatrics, I felt the importance Director Emeritus, National Library of Medicine of Hattie Alexander’s contributions to infectious disease and Dorothy Andersen’s to cystic fibrosis. P&S History: Fraternities There are other important and instructive articles in that issue but these I am trying to get information about a fraternity that existed at Columbia that hit me personally stand out. College of Physicians and Surgeons in the early 20th century. A fraternity Paul R. Lurie’42 pin that I believe comes from the college consists of two triangles, one New Paltz, N.Y. imposed on the other. On the front of one appear a skull and crossbones and the Greek word O iatros, which means the physician. On the other I write in fond memory of Robert Loeb, a name known to fame at P&S. triangle appears the Greek letters Chi Zeta Chi, although the order could A number of reminiscences in the past seemed chary of his praise. I found be different—e.g., Chi Chi Zeta, etc. Dr. Loeb to have been one of the two great teachers in my life, as a stu- My father, Thomas E. Quigley, graduated from P&S in 1918. I have dent, faculty member, and practitioner. Others have noted that he did this pin, together with another one consisting simply of a skull superim- not tolerate unpreparedness or unprofessionalism (or even its semblance) posed, not on crossbones but on crossed keys, looking vaguely like the in his students or associates. Why should he? Would this kind of “toler- papal crossed keys of Peter. Any information about either would be most ance” of incompetence have helped us, him, or a patient? gratefully received. A specific question: Did P&S have its own Greek fra- ternities at that time? Tom Quigley Via email Bonita Eaton Enochs, Editor send letters to: Columbia Medicine College of Physicians & Surgeons Editor’s Note 630 W. 168th St., P&S Box 153 Archives & Special Collections has no records of fraternities, other than New York, NY 10032 the Alpha Omega Alpha honor society, that existed before 1924. Any Email: [email protected] reader having information to share with Mr. Quigley may send it to [email protected].

2 ColumbiaMedicine Spring/Summer 2017 News from around the College of Physicians & Surgeons PS& news

100 Years of Columbia Urology J. Bentley Squier

rology at P&S started in 1917 when losis, a form of advanced kidney infection; and • Meyer Melicow formed the Squier Urological J. Bentley Squier, an 1894 graduate of outline and use the now ubiquitous prostate- Pathology Section and published extensively, earn- U P&S, founded a clinic with the sup- specific antigen (PSA) density test. ing him the moniker “Father of Uropathology.” port of his many generous patients throughout • John Lattimer’38, who became chair in 1955, the world. When Columbia-Presbyterian Medi- Other highlights: expanded pediatric urology and developed cal Center opened in 1928, the Squier Urologi- • George F. Cahill, who became chair in 1939 innovative treatments for prostate cancer, com- cal Clinic had its own operating and cystoscopy after the sudden death of Dr. Squier, specialized bining different surgeries to prolong life. He rooms, pathology and X-ray departments, and in adrenal surgery and early investigations into conducted research and innovative treatment of library. He also established a 30-bed pediat- the care of patients with pheochromocytoma, genitourinary tuberculosis. ric urology service in the medical center’s new a nonmalignant tumor of the adrenal glands. • Carl A. Olsson, who became chair in 1980, Babies Hospital. The clinic became a formal Under Dr. Cahill’s direction, a cancer research was respected for his work in urinary diversion department, with Dr. Squier as chair, in 1935. service began at the Francis Delafield Hospital, surgery and reconstructive urology. Under his A century after its founding, P&S urology is leading to innovative basic and translational leadership, the department’s molecular biol- ranked as a leading urology program and one cancer research. Dr. Cahill also reported that ogy research program flourished and garnered of the top recipients of NIH funding. Urology human chorionic gonadotropic hormones cure national recognition for fundamental work in faculty were the first to characterize bladder cryptorchidism, the absence of one or both tes- castration-resistant prostate cancer under Ralph carcinoma in situ (localized), treated differently tes from the scrotum, the most common birth Buttyan. Innovative techniques introduced dur- from other such cancers; describe renal tubercu- defect of the male genitals. ing Dr. Olsson’s tenure include prostate cryo- surgery, robotic and laparoscopic surgery for prostate cancer, continent urinary diversion for bladder cancer, and nephron sparing surgery for kidney cancer. Landmark studies in serum biomarkers for prostate and kidney cancers also occurred during Dr. Olsson’s tenure. • Mitchell Benson’77 succeeded Dr. Olsson as chair in 2006. He is credited with describ- ing the concept of PSA density in the diagnosis and monitoring of prostate cancer. Dr. Benson expanded a basic science research division with- in the department and consolidated all urologic research laboratories into the new cancer center facility. The department opened its first satel- lite division of urology, in Miami, Fla., which has five full-time faculty and its own residency training program. • The department’s current chair, since 2014, is James McKiernan’93. He leads a team of researchers investigating the clinical outcomes of patients with kidney, prostate, and bladder cancer. Under his leadership, the department John Lattimer, urology chair from 1955 to 1980, during grand rounds at Babies Hospital in 1964 opened its first Westchester office.

www.columbiamedicinemagazine.org 3 PS& news

AMELIA PANICO Residency Match 2017

Family and friends joined the P&S Class of 2017 in Bard Hall on March 17 for the annual distribution of residency match envelopes as medical school seniors across the country found out where they will train. According to the National Resident Matching Program, this year’s match was the largest in Match history, with a record 35,969 U.S. and international medical school graduates vying for a record 31,757 positions. The P&S Class of 2017, the largest class in P&S history, had 167 students participating in the match. Most of the graduates matched to residencies in cities on both coasts: Boston, New York, Phila- delphia, San Francisco, and Los Angeles. More than one-third of P&S graduates will complete all or part of their training in New York City (39 percent will remain in New York state). The most popular residencies: internal medicine (46 students), anesthesiology (12), psychiatry (12), pediatrics (11), obstetrics & gynecology (10), and radiology/diagnos-

EVE VAGG tic and interventional (10). EVE VAGG

4 ColumbiaMedicine Spring/Summer 2017 Expanded Pipeline Program Emphasizes Intraprofessional Health Care

A pipeline program intended to increase the number of health care profes- erson, MD, senior associate dean of diversity and multicultural affairs at sionals from underrepresented groups will offer studies in all fields available P&S and PI of the Columbia SHPEP site. (Co-PIs are Dennis Mitchell, at Columbia University Medical Center: medicine, dentistry, nursing, public DDS, vice provost for faculty diversity and inclusion at Columbia Univer- health, occupational therapy, physical therapy, and nutrition. sity and senior associate dean for diversity at the College of Dental Medi- Columbia is one of 13 institutions nationwide to participate in the cine, and Vivian Taylor, EdD, associate dean for diversity and cultural expanded Summer Health Professions Education Program funded by the affairs at the School of Nursing). “You need to have a team, health pro- Robert Wood Johnson Foundation. Previously limited to medicine and fessionals working together for efficiency and great medical care. We pre- dentistry, the free enrichment program allows first- and second-year col- sented a proposal that showed how the programs would work together.” lege students to spend several weeks at the medical center. The program’s About 1,400 college students apply to Columbia’s program every year, new name reflects its broader focus on intraprofessional education and though only 80 spots are available. “Being at Columbia, one of the top the belief that patients receive better care when providers work collab- medical centers in the country, and in New York City is a huge draw,” Dr. oratively and across specialties. Hutcherson says. “We’re looking for students who need assistance, who This is the first time all academic programs at CUMC will work together need encouragement, who need the resources. I think the encouragement we on a so-called pipeline program to encourage participants to consider provide is the most important thing we do, because often these students have careers in health care. “I think that was the strength of our application, never been told, ‘Yes, you can do this! And this is the way you can do it.’ that we have these seven programs on one campus,” says Hilda Hutch- Those are the students we’re reaching for.”

Learning How to Screen for Substance Abuse Co-Ed Medical Education

A new program designed to teach students how to screen patients for substance use dis- This year marks the 100-year anniversary of the orders has been implemented for P&S and dental students at Columbia. The program, admission of women to P&S. In 1917, a Barnard Col- funded by a grant from the Substance Abuse and Mental Health Services Administration, lege senior, Gulli Lindh, started a campaign to gain is integrated into the required curriculum over the course of all four years. admission to P&S. After several meetings with the The program aims to teach a variety of approaches to screening and brief interven- P&S dean and receipt of an anonymous gift to pay tions that take a nonjudgmental approach to substance use by applying evidence-based for physical plant changes to accommodate women, methods that have been shown to reduce rates of heavy drinking, nicotine use, and drug Ms. Lindh joined 10 other women who began medi- use among patient populations. cal school in the fall. Students who participate in the program are being introduced to SBIRT (Screening, Dr. Gulli Lindh Muller (she married in her junior Brief Intervention, and Referral to Treatment) and techniques for motivational interview- year) graduated first in her class in 1921. After train- ing. The program uses multiple teaching techniques, including lectures, videos, small- ing at Presbyterian Hospital she joined the P&S fac- group discussions, role-playing, and screening of standardized patients to help students ulty, later resigning to move to Massachusetts for learn and practice SBIRT. Standardized patient encounters, modeled on a part of the her husband’s new job. board certification process for physicians, allow students to practice history taking and In the years from 1921 to 1941, 175 women grad- physical exam skills to prepare to see patients in clinical settings. uated from P&S, a third of them graduating with The Substance Abuse and Mental Health Services Administration has funded initia- honors (compared with only 13 percent of the men). tives to introduce SBIRT training nationally, although mostly for residency programs up As of the late 1950s, 85 percent of them were still until the past year. Increasing awareness about the impact of excessive substance use on practicing medicine. Application rates were low, health care outcomes across the country has prompted the agency to expand the initia- however. On average, 50 women applied each year tive by adapting the curriculum for medical students to introduce concepts earlier in the compared with about 1,000 men. The school lim- course of a doctor’s training. ited women to 10 percent of the class. Today, appli- “Doctors have a lot more impact than they think they have in changing a patient’s cation and enrollment numbers of women at P&S behavior,” says Frances R. Levin, MD, the Kennedy-Leavy Professor of Psychiatry in the are approximately equal to the numbers of men, Division of Substance Use Disorders and the PI for the training program at Columbia. and the number of women has often surpassed the “We try to get the students comfortable with simply asking patients the questions.” number of men enrolled. Dr. Levin hopes to expand the program next year to residents and ultimately offer the course to students at other CUMC schools. Read more about P&S history at ps.columbia.edu/250.

www.columbiamedicinemagazine.org 5 PS& news

Class of 2019 Starts Major Clinical Year Members of the Class of 2019 started their major clinical year with the Jan. 6 Steven Z. Miller Student Clinician’s Ceremony, which marks the transition of second-year students from the classroom to patient-centered training in hospital and ambulatory settings. The class gathered for a group photo in the Vagelos Education Center. The ceremony is named for the late Steven Z. Miller’84, who created

the first transition ceremony at P&S in 1998. AMELIA PANICO

News in Brief

Two P&S faculty members were elected last fall in E. coli and how termination affects other Prevention’s training curriculum for community to the National Academy of Medicine, formerly cellular processes; Wei Gu, PhD, the Abraham health workers, is led by Dr. Williams, associate the Institute of Medicine: Carol Friedman, PhD, and Mildred Goldstein Professor of Pathol- professor of neurology, chief of staff of neurol- professor of biomedical informatics, and Anissa ogy & Cell Biology (in the Institute for Cancer ogy, founder of Hip Hop Public Health, and Abi-Dargham, MD, professor emeritus of psy- Genetics) for his contributions to the field of co-director of the Center for Stroke Disparities chiatry. Dr. Friedman is an expert in natural protein modifications in modulating stress Solutions in New York. The center also will be language processing for biomedical applications. responses, particularly for acetylation/deacety- a home base for Mental Health First Aid, a pro- lation and ubiquitination/deubiquitination in gram dedicated to improving access to quality p53-mediated tumor suppression; and Paul mental health services in Upper Manhattan. The Sajda, PhD, professor of biomedical engineer- program, founded by Dr. Hankerson, assistant ing and of radiology, for contributions to the professor of clinical psychiatry, works with local understanding of neural correlates of vision, faith communities to train leaders to identify and human perceptual decision-making, and corti- respond to signs of depression and other mental cally coupled computer vision. illnesses, as well as substance use disorders like alcoholism and drug addiction. In addition to Two P&S faculty members will lead a new com- stroke and mental health awareness programs, munity wellness center located in the Jerome L. the center will provide free blood pressure read- Greene Science Center on Columbia’s new Man- ings and cholesterol tests on weekdays and select Carol Friedman, PhD, and Anissa Abi-Dargham, MD hattanville campus. Neurologist Olajide Wil- weekends to all who walk in. liams, MD, and psychiatrist Sidney Hankerson, Dr. Abi-Dargham, who is now professor of psy- MD, are known for their pioneering approaches Three P&S faculty members received grants chiatry at Stony Brook University, uses imaging to improving public health in Harlem and last fall through Columbia’s faculty diversity studies to uncover the pathophysiology of schizo- Washington Heights. The center will operate initiative, the Provost’s Grants Program for phrenia, schizophrenia-related disorders, and with support from Columbia’s Mortimer B. Junior Faculty Who Contribute to the Diver- addiction to reveal chemical changes that occur Zuckerman Mind Brain Behavior Institute. sity Goals of the University: Richard Francis, that may potentially serve as risk markers for the The center will house the Community Health MD, PhD, assistant professor of pathology disease and improve interventions. Worker Stroke Prevention program, designed to & cell biology, for “Localization of Stored raise awareness about one of the leading causes Platelets to Sites of Active Bleeding Following The American Association for the Advance- of death and disability in the United States. The Transfusion”; Monica Goldklang, MD, assistant ment of Science named three P&S faculty free program includes six-week training sessions professor of medicine (in anesthesiology), members as 2016 AAAS Fellows: Max E. Got- held throughout the year that will give local resi- for “In Vivo Imaging of Lung Apoptosis in tesman, MD, PhD, the Charles H. Revson Pro- dents the tools they need to become community Alpha-1 Antitrypsin Deficiency”; and Esi fessor of Biochemistry & Molecular Biophysics health workers. Volunteers will learn about car- Lamousé-Smith, MD, PhD, assistant profes- and of Microbiology & Immunology, who was diovascular health issues, with a special emphasis sor of pediatrics, for “Infant Gastrointestinal selected for his fundamental insights leading to on stroke and related risk factors. The program, Tract Microbiome Dysbiosis and its Impact on the understanding of transcription termination modeled on the Centers for Disease Control and CD8+T Cell Gene Transcription Regulation.”

6 ColumbiaMedicine Spring/Summer 2017 Bridging Gaps in Residency Readiness

All medical school graduates should be ready to conduct routine clinical some kind of supervision, some kind of assessment—and opportunities activities when they begin residencies, but gaps exist that reveal dispari- for remediation if you need them. The kind of curriculum that you have ties between what residency program directors expect interns to do and to develop is pretty significant.” what the interns feel ready to do. The 10 schools tapped for the five-year pilot program have worked together In response, the Association of American Medical Colleges developed for the past few years to develop more consistent curricula, assessment meth- a list of 13 core “entrustable professional activities”—EPAs—that new ods, and an overall structure of coaching. “Coaching is meant to help students physicians should be able to perform without supervision on their first reflect on what kind of information they’re getting back about their own per- day of residency. P&S is one of 10 U.S. medical schools chosen for a pilot formance so that they can improve it over time and can request or seek out program to integrate EPAs into their curricula. additional opportunities for enrichment. The hope is that by the end of medical EPAs range from relatively simple things—taking a medical history, school, every medical student will feel confident to perform the activities that performing a physical exam, doing common procedures, writing notes, we’re focusing on and be really strong when they start out their internships.” and making oral presentations—to more sophisticated activities, such as getting involved in quality improvement projects or handing off cases Of the 13 EPAs, P&S has focused on four: to other members of the care team, says Jonathan Amiel, MD, associate • taking a medical history and performing a physical exam professor of psychiatry and associate dean for curricular affairs at P&S. • documenting a clinical encounter in the patient record “All of these are clearly important in terms of taking care of patients.” • providing an oral presentation of a clinical encounter Results of an AAMC poll of program directors and graduating students • performing general procedures of a physician showed agreement in confidence on certain EPAs—getting a history, taking a physical, and making presentations—but significant gaps in other areas. Educational content addressing those EPAs was incorporated into the “For instance, the program directors had significantly less confidence in stu- P&S curriculum beginning with the Class of 2019. “We’ve set up a longi- dents’ ability to do handoffs than the students had. Program directors had tudinal coaching program where each student has a coach that teaches in more confidence in students’ abilities to do common procedures than the our Foundations of Clinical Medicine seminar course for first-year students students did,” says Dr. Amiel. “What happens when there’s this kind of gap but also stays with the student over the course of the four years,” says Dr. is that when interns are just starting their graduate medical education, they Amiel. “The students meet with the coaches once or twice a semester to go may be cautious in communicating what they’re not confident in because over how medical school is going, what kind of feedback they’re getting— they want to make a good impression on their supervisors, and if they’re both directly observed by the coach in the Foundations course and later on assigned to something that they don’t feel qualified or confident to do, they clinical services and in clinical skills assessments. Our aim is to establish a may try to do it anyway without asking for enough training or supervision, trusting relationship between the coach and the student so that students and that could result in pretty significant lapses in patient safety.” can come to coaches over the course of their medical school education with Basic procedures cannot be learned overnight, says Dr. Amiel. “You the feedback that they’ve gotten and try to interpret it so that they can cre- have to learn the basic principles and then practice them over time with ate their own short-term and long-term learning plan.”

Having Our Cake and Eating It Too

A cake baked by a local bakery to commemorate the 250th anniversary of P&S was judged the overall winner of a January “Cake Off” held to celebrate several medical center anniversaries. A panel of community judges viewed and tasted cakes made to represent P&S (250 years), the School of Nursing (125 years), the College of Dental Medicine (100 years), and the Mailman School of Public Health (95 years). The cakes were judged on taste, appearance, and how well each cake represented the mission of the school. The P&S cake, created by Make My Cake bakery, portrayed the new Vagelos Education Center. The cake also depicted books authored by Columbia faculty and alumni. CUMC faculty and staff were invited to taste each school’s cake and vote on their favorite. The College of Dental Medicine cake, which depicted the dental school mobile van, received the most votes. The cake was baked by Bizcocho De Colores bakery.

www.columbiamedicinemagazine.org 7 New devices, procedures, guidelines for clinicians Clinicaladvances

Management of Pulmonary Arterial Hypertension

ulmonary arterial hypertension, considered a death sentence just to treat the disease. For the past 30 years, the center has been at the a generation ago, is a rare but serious disease that occurs when forefront of research, including major clinical trials, landmark genetic Pthe walls of the lung’s arteries stiffen and narrow, raising blood discoveries, and pioneering treatments such as mechanical support for pressure in these arteries. The lungs can be permanently damaged, and patients who fail advanced medical therapy. the heart must pump harder to push blood through the lung, leading to “We have led the way in both pediatric and adult pulmonary arterial life-threatening heart failure in children and adults. hypertension management and research by offering the most advanced “Two decades ago, patients diagnosed were told they had one to two medical therapies, often through clinical trials,” Dr. Rosenzweig says. years to live,” says Erika Berman Rosenzweig, MD, associate professor of “We have been involved in all of the pivotal drug trials that have led to pediatrics (in medicine) and medical director of the Pulmonary Hyperten- FDA approval of the 14 medications available for the disease.” sion Comprehensive Care Center at Columbia. The center has become known for providing the most advanced medi- “Now, with new advances, we have patients who have been managed at cal care for the sickest patients. Surgeries that would not have been con- the center for more than 20 years and going strong,” Dr. Rosenzweig says. sidered previously are now possible. “This evolution has been amazing to be a part of and has enabled patients The center has pioneered the use of ECMO—an external machine that to live longer and stronger with pulmonary arterial hypertension.” oxygenates blood—in pulmonary hypertension patients as a bridge to a The Pulmonary Hypertension Comprehensive Care Center at Colum- lung transplant or to help patients recover from a life-threatening crisis. bia is one of the first—and among the largest—in the world established “Previously these patients were not offered ECMO because it was thought they could not be weaned from the support or survive long enough on ECMO while waiting for an organ,” says Matthew Bacchetta, MD, associate professor of surgery and the center’s surgical director. “At Columbia, ECMO is being successfully used and, in many cases, physical condition improves and patients become better candidates for a transplant.” Dr. Bacchetta is among only a few surgeons in the world who perform surgery for chronic thromboembolic pulmonary hypertension, which hap- pens when thrombi build up in the pulmonary arteries. During the proce- dure, called pulmonary thromboendarterectomy, the blockages are surgically removed from the lungs. “It’s an attractive alternative to lung transplantation and is associated with better long-term survival, although the procedure isn’t well-known among most physicians,” says Dr. Bacchetta. “As the center sees patients surviving longer, we are now challenged with how to manage them through comorbid conditions,” says Dr. Rosenzweig. “We are proud that our team can literally change lives and improve out- comes on a daily basis for a disease that was recently considered universally fatal. To see patients get back out there and attend school, work, or travel and be an active member of their community gives us tremendous pride in the work we do.” —Jeff Ballinger

The Pulmonary Hypertension Comprehensive Care Center treats all forms of pulmonary hypertension, including hypertension caused by other condi- tions. For more information, contact the center at 212-305-4436.

8 ColumbiaMedicine Spring/Summer 2017 Keeping Children’s Digestive Health on Track

Children with celiac and other gastrointestinal problems now have greater CUMC and director of the Pediatric Gastrointestinal Motility Center; Sivan access to treatment with last year’s opening of the Phyllis and Ivan Kinberg, MD, assistant professor of pediatrics (in biomedical informatics) Seidenberg Center for Children’s Digestive Health. The center features at CUMC, who directs the Pediatric Intestinal Rehabilitation Center; Ali a multidisciplinary team of specialists who care for children with both Mencin, MD, assistant professor of pediatrics at CUMC, who directs the simple and complex illnesses. Pediatric Fatty Liver Clinic; and Joseph Picoraro, MD, assistant professor of The center, located in the Morgan Stanley Children’s Hospital, was made pediatrics at CUMC, who coordinates care for inflammatory bowel disease. possible by a $15 million donation from Phyllis and Ivan Seidenberg. Dr. Picoraro is developing precision medicine projects to investigate The new center has led to dramatic improvements for patients and the genetic causes of gastrointestinal disorders. Meenakshi Rao, MD, physicians, says the team’s leader, Joel Lavine, MD, PhD, professor and PhD, assistant professor of pediatrics, investigates the development of the vice chair of pediatrics. “Prior to this center’s opening, the Division of neuro-enteric system and consequences related to motility. Arun Singh, Gastroenterology, Hepatology, and Nutrition did not have its own outpa- MD, a postdoctoral clinical fellow, studies the role of epigenetics in the tient space to see patients, and our ability to recruit physicians to expand expression of genes implicated in celiac disease. capacity was limited. We now have 15 expansive exam rooms; nurse “The expertise available in this center is unparalleled,” Dr. Lavine says, practitioners and dietitians are easily accessible to patients; and we are “in terms of quality, access, and interdisciplinary care.” capable of accommodating more than 25,000 patient visits per year.” The Seidenberg gift also supports center research into eradicating celiac The center has recruited more specialists to provide multidisciplinary and other digestive diseases. approaches in treating complex digestive problems. Recent recruits include —Jeff Ballinger Jennifer Woo Baidal, MD, assistant professor of pediatrics, who specializes in childhood obesity; Julie Khlevner, MD, assistant professor of pediatrics at Appointments may be requested by calling 212-305-5903.

Children Undergoing Heart Surgery at Columbia Have Lowest Mortality in New York State

Children who have heart surgery at NewYork- nurses in the pediatric heart team,” says Emile pregnant and you know your child has a heart Presbyterian/Columbia have the lowest risk- Bacha, MD, chief of cardiac, thoracic, and vas- defect. Babies sometime get into trouble right adjusted mortality rate among all programs cular surgery. after birth, and it’s better to have all the neces- in New York state, according to a report pub- According to the report, CUMC performed sary resources under one roof.” lished last fall describing pediatric congenital the most pediatric heart surgeries in the state– Columbia’s pediatric heart surgeons also cardiac surgery in New York state from 2010 1,558 over four years–and had the lowest risk- participate in the Society for Thoracic Sur- to 2013. adjusted mortality rate of 2.26, a rate that was gery’s Congenital Heart Surgery Database, The report compiled data from patients under significantly lower statistically than the state- which was created in 1989 to monitor patient 18 years of age who had surgery to correct con- wide rate. care. In the past few years, surgical outcomes genital heart defects. New York is the only state A unique aspect of Columbia’s pediatric heart at Columbia have ranked among the best in that collects and releases this information about team is the integration of neonatologists who North America. pediatric cardiac surgery. specialize in heart disease. “I believe that these Historically, Columbia surgeons have earned a “We are very pleased, and the results are a specialists have developed outstanding manage- position at the forefront of pediatric cardiac sur- testament to the quality of all the doctors and ment skills of these babies that has helped us gery through such achievements as the first success- achieve superior results,” says Dr. Bacha. He ful pediatric heart transplant in 1984. Columbia is also credits Columbia’s surgical and technical now one of a few centers in the United States to Correction experience and multidisciplinary team approach. offer hybrid cardiac surgery—combining conven- “I advise parents that the experience of the tional surgical methods with catheter-based tech- The balance disorders center phone number published in the Fall/Winter 2016 issue was team is the most important thing to ask about,” niques—for infants and children. incorrect. The correct phone number is he says. “You want a center that does hundreds — Susan Conova 212-305-0029. The center’s website is www. of cardiac surgeries a year, literally several sur- entcolumbia.org/our-services/balance-disorders. geries every day. It’s also very important to For an appointment or a second opinion con- seek care at a multidisciplinary unit if you’re sultation, call 212-305-2688.

www.columbiamedicinemagazine.org 9 P&S HISTORY: Years of Medical Education, Research, and Care

Lee Goldman, Dean No. 23: 11 Years of Leadership and Counting

he P&S that greeted Lee life. The ongoing success of that blue- Goldman, MD, when he print for excellence is echoed by faculty left a department chair- and institutional leaders who look back manship at the University on the Goldman Years of P&S history of California San Fran- and applaud the progress made toward Tcisco for the medical school dean’s job the goals set during the strategic plan- at Columbia in 2006 had a far different ning process. look—literally and figuratively—than Steady growth defines the past decade at today’s P&S. In the 11 years since Dr. P&S: increased NIH funding for research, Goldman became dean, he has joined with greater recruitment of faculty at all levels, the school’s faculty, alumni, donors, staff, a more diverse and selective student body, students, and other partners to imple- improved clinical care with better patient ment a new medical school curriculum, access, and improvements to the campus build the new Vagelos Education Center, that make the medical center a welcom- increase research funding, grow the fac- ing place for all. Although Dr. Gold- ulty practice, improve faculty and student man emphasizes that everyone shares diversity, attract historic levels of philan- the credit for success, individuals inter- thropy, and identify ways to enhance the viewed about the Goldman tenure cite on-campus experience for everyone who his single most important early achieve- studies, works, or visits P&S. ment as the one that has enabled the The positive developments align with others: stabilization of the financial priorities outlined in the strategic plan situation of the entire medical center for P&S, “2020 Vision,” as pillars of (of which he serves as executive vice excellence: clinical care, research, edu- president and chief executive). Senior cation, and campus and community faculty and department chairs credit

By Elizabeth Chute The College of Physicians & Surgeons on 23rd Street, circa 1856 Dr. Goldman with innovative leadership that resulted led to a freeing up of space that could be used to recruit new in a fiscal transformation that, in turn, created greater faculty and generate new research funding. investment and growth in all areas. The transformation was remarkable. “Suddenly an One of the key challenges Dr. Goldman faced upon arriv- institution that did not have a new research building on ing was how to make finances more transparent—recogniz- the drawing board could now generate over 100 thou- ing the true costs of doing business and how to obtain the sand square feet of space and that space could be filled,” funds to pay them, says Donald Landry, MD, PhD, chair Dr. Landry says. It placed an added premium on NIH- of the Department of Medicine. The dean correctly read funded space, which brought in adequate funding and, the origins of the problems, primarily the lack of incentives importantly, provided a strong metric for success. for controlling costs and inadequate incentives for raising After achieving financial stability, P&S was able to funds for research with adequate indirect cost coverage. He maintain a margin for growth and investment. “All of also placed more responsibility on departments and individ- this is designed to increase the NIH funding of the insti- ual investigators to account for space they occupied, which tution, which is important for our mission—national leadership for research and innovation—but also it’s A clear sign of growth is in the research portfolio: part and parcel of our financial stability upon which all of our scientific progress is based,” says Dr. Landry. As NIH grants to P&S have increased 44 percent in Dr. Goldman often says, “The goal is to be indisputably the past seven years, during a time in which the in the top five and arguably the best at everything an aca- demic medical center should do.” A healthy financial situ- NIH budget increased only 5.8 percent. ation is a means to that goal, not the goal itself.

Lee Goldman, MD

JÖRG MEYER

12 ColumbiaMedicine Spring/Summer 2017 * Getting the institution on better financial footing was done P&S Leaders since 1767 objectively and without favoritism, says Eric Kandel, MD, Samuel Bard, 1767-1776, 1791-1804, 1811-1821 University Professor and director of the Kavli Institute for Nicholas Romayne, 1807-1811 Brain Science. “Dr. Goldman has been very successful. This is Wright Post, 1822-1826 a very diversified environment, and he’s restructured it estab- John Watts, 1826-1831 lishing trusting relationships with the various senior faculty.” John Augustine Smith, 1831-1843 Mary D’Alton, MD, chair of the Department of Obstet- Alexander Stevens, 1843-1855 rics & Gynecology, credits Dr. Goldman with steering Thomas Cock, 1855-1858 a positive course for the medical school with his early Edward Delafield, 1858-1875 reforms and exercising a singular focus on excellence that Alonzo Clark, 1875-1884 has a trickle-down effect to the rest of the medical school. John Dalton, 1884-1889 “This focus and commitment to excellence over a 10-year James McLane, 1889-1903 period has achieved significant results, and you can see a Samuel Lambert, 1904-1919 compounding effect of his many decisions on the overall William Darrach, 1919-1930 state of the medical center,” she says. Willard Rappleye, 1930-1958 H. Houston Merritt, 1958-1970 Increasing the Research Profile Paul Marks, 1970-1973 A clear sign of growth for P&S is its NIH research pro- Donald Tapley, 1973-1984 file, with NIH grants to P&S increasing 44 percent in Henrik H. Bendixen, 1984-1989 the past seven years, a time in which the NIH budget Herbert Pardes, 1989-1999 has increased only 5.8 percent. “It is a clear indication David Hirsh, interim dean for research, 2000-2001 that the research enterprise is moving and it is moving Thomas Q. Morris, interim dean for clinical and educational affairs, 2000-2001 across a wide range of departments,” says Dr. Goldman. Gerald D. Fischbach, 2001-2006 “The faculty have performed very admirably and it is Lee Goldman, 2006- very rewarding to me—and I think to all of Columbia University—to see this vibrancy in the research mission.” * some leaders were deans; others were presidents, particularly of P&S before it merged The research growth is led by awards and gifts for pre- with Columbia’s medical school cision medicine, a focus of the research vision for P&S and a priority adopted by Columbia University Presi- dent Lee Bollinger as a multicampus collaboration, led of the Department of Surgery: “When I’ve told him, ‘This by Tom Maniatis, PhD, chair of the Department of Bio- is a person we must have to reach this goal,’ he could eas- chemistry & Molecular Biophysics. ily have said, ‘You’ve already overspent the check.’ Instead, In partnership with NewYork-Presbyterian Hospital, P&S he’s been more than willing to step up and go somewhat recruited David Goldstein, PhD, to head the new Institute beyond that to hire the right people.” for Genomic Medicine, further investing in and advancing In the past five to seven years, P&S has recruited at the research vision of precision medicine. Led by Dr. Gold- all levels—from junior and senior faculty to department stein, the Institute received one of the first NIH grants to chairs—at a rate of 9.5 percent per year. An annual depar- participate in a new national precision medicine program. ture rate of 3 percent to 4 percent results in a net increase “We’ve already made great strides in precision medicine to of 5 percent to 6 percent a year. “That growth has really make it a full university priority with great support from helped fuel the success of our missions,” says Dr. Gold- NewYork-Presbyterian and the NIH,” says Dr. Goldman. man, adding that it sends an important message internally Research at all levels is critical to improvements in and outside the institution that outstanding clinicians, clinical care and patient outcomes. A recent example in researchers, and educators are joining the faculty. obstetrics would be research conducted here that shows P. Roy Vagelos, MD, chair of the CUMC Board of promise to reduce neonatal respiratory problems, says Dr. Advisors, describes the effect of recruiting outstanding D’Alton. “Dean Goldman is a champion of our research faculty and its impact on attracting other faculty and initiatives,” she says, “and while, of course, we incorpo- students. “Faculty continue to grow in numbers and the rate research from other academic medical centers, it is quality is superb. Good recruits lead to good recruits, on incredibly rewarding when it is developed internally and both the basic research and clinical side,” he says. often has a more immediate impact on our clinical care.” Student applications have continued to rise over the Recruitment is also key, and faculty chairs credit Dr. past decade: now approximately 8,000 annual applicants Goldman with supporting their goals of attracting the right with an acceptance rate of 4 percent. “The quality of people to reach strategic goals. Says Craig Smith, MD, chair the students is superb,” says Dr. Vagelos, a 1954 gradu-

www.columbiamedicinemagazine.org 13 ate of P&S. “We compete with very few schools for the eficial effect on patient care and access, but it also aids level of students we’re bringing in. We select students physicians, offering the protection of a larger organization who are capable of being the best of the physicians who and help with operational issues, such as joint contract- will practice medicine and the best of physicians who will ing with third-party payers, negotiating better rates from do research.” insurers, and bringing down malpractice costs. Along with the growing number of applicants and “Today it is hard for any doctor, especially an individual increased selectivity, the student body has become more doctor in private practice, to keep his or her head above diverse in the past decade, outperforming peer institu- water, especially in the broader primary care specialties,” says tions. Between 20 percent and 25 percent of the student Dr. Smith. The FPO has been important for maintaining the body is consistently made up of underrepresented minor- financial viability of all practices and for improving patient ities, with half men and half women—critical to serving access. “This can’t be done by a smaller group or practice.” a community and patient population that is increasingly Expansion also has brought Columbia doctors closer diverse. “We serve a diverse population, and I think it to more patients. New practices in the northern suburbs is imperative that our faculty, staff, and students simi- and development of midtown and other new facilities in

One of several new facilities larly reflect the diversity of that patient population,” says New York City have contributed to overall growth on built during the Goldman Dr. D’Alton. “I think it’s something we always need to the clinical side that has averaged close to 10 percent for years is ColumbiaDoctors work on and be mindful of.” the past several years. Midtown, which opened in January 2013 on West 51st Progress in clinical care has developed naturally through Street. Physicians, nurse Expanding Clinical Care a strong and collegial working relationship with NewYork- practitioners, and dentists A second key priority for P&S under Dr. Goldman’s lead- Presbyterian. “The foundation for our progress in clinical see patients in a three-story space that includes 125 exam ership is clinical care, with improved patient care and care has been our close working relationship with the hos- rooms, 30-plus procedure better access for patients. The effort goes to the heart pital,” says Dr. Landry. “The investment from the hospital rooms, and other facilities that cover 125,000 square of the institution’s mission: “Clinical care is the reason in extraordinary physicians with exceptional capabilities, feet. The location offers lab academic medical centers exist in the first place. I think leaders in clinical innovation, often clinical investigators, has services, an imaging suite, what’s really been striking here is the way we’ve been caused startling changes everywhere we look throughout the and physical, occupational, and sports therapy facilities. able to grow,” says Dr. Goldman. medical center.” He notes, as examples from within Medi- The midtown facility is part of The flourishing FPO, or faculty practice organization, cine, interventional cardiology, the comprehensive array of a substantial expansion of the faculty practice organization known as ColumbiaDoctors, has grown substantially dur- organ transplantation services, the many domains of medi- over the past decade. ing the past decade. A stronger FPO not only has a ben- cal oncology, interventional GI endoscopy, and ICUs. “Our growth exemplifies the vision of the dean and the NYP CEO—that we must provide care at a minimum level of excellence across everything we do, with a significant num- ber of areas where we are extraordinary. And that is actually about where we are today.” Patients, doctors, and the community all benefit. Working with the hospital, P&S has further strengthened “already great” programs in organ transplantation, pediatric neona- tal and intensive care, cardiology, cardiac surgery, and spine surgery, “just to name a few that attract people from all over the country, all over the world,” says Dr. Goldman. The “Best Hospitals” ranking of NewYork-Presbyterian as No. 1 in New York City and No. 6 among American hospitals is a source of shared pride, and the six specialties in which the hospital ranks in the top five—cardiology/heart surgery, diabetes/endocrinology, nephrology, neurology/neurosur- gery, psychiatry, and rheumatology—are all areas in which Columbia doctors are among the tops in their fields.

Education: On the Leading Edge Efforts to achieve a third strategic goal for P&S— strengthen the curriculum for medical students—have drawn positive reviews from throughout the medical school community. The goal was to have educational

14 ColumbiaMedicine Spring/Summer 2017 A focus of the P&S research vision is precision medicine, a priority adopted by Columbia University President Lee Bollinger as a multicampus collaboration. The Columbia Precision Medicine Initiative utilizes the intellectual resources of Columbia faculty in medicine, science, and technology to leverage this revolution in health care. With support from Columbia and NewYork-Presbyterian Hospital, P&S has invested in the Institute for Genomic Medicine, which has received Institute for Genomic Medicine lab one of the first NIH grants to participate in a new national

JÖRG MEYER precision medicine program.

programs define what every medical student should And when the sun sets, the center becomes a beacon in know, then give each student the flexibility to pursue the neighborhood.” The building is not only an archi- specific areas of interest. The practical implementation tectural masterpiece, says Dr. Goldman, but, from a of that resulted in shortening the preclinical curriculum practical perspective, is also “a great place to study, to to 16 months from two years and requiring a scholarly learn, to relax. We’ve seen every nook and cranny of the project—all with the aim of focusing the medical stu- building used the way the architect designed it. That’s dents on inquiry in a more substantive way. been very rewarding. The building would not have been The school reduced sharply the number of lectures and possible without the generosity and vision of Roy and put students together in small groups so they could work Diana Vagelos. We remain very grateful to the many together to solve problems. It also made a large commit- donors, including the Cheryl and Philip Milstein Fam- ment to simulation to help students improve physician- ily, the Helen and Clyde Wu’56 Family, and the Mary patient encounters and learn skills needed in the ICU, operating rooms, and other venues. An advantage of the education reforms undertaken by Many of the medical center buildings are almost P&S is that students are allowed time for scholarly proj- ects that are broadly conceived, allowing them to pur- 100 years old, so upgrading the physical plant has sue individual interests at a rigorous level. Curriculum included new buildings, renovation of hundreds of reform is not unique to P&S, as other medical schools have followed Columbia’s lead to shorten the preclini- thousands of square feet of space, and improvements cal portion of the curriculum to expand opportunities in elevators, stairwells, bathrooms, and corridors. for clinical electives and scholarly inquiry. P&S needed to undertake the reforms, says Dr. Landry: “If we sat back and didn’t make education a priority we might have and Michael Jaharis Family, who were instrumental in risked tarnishing a jewel of the institution.” bringing the building to fruition for the benefit of future The new Roy and Diana Vagelos Education Center generations of students at P&S.” at P&S, which opened in August, encourages the kind Education at P&S continues to evolve in other ways of learning reflected in the curricular reforms, provid- as well. New departments—the Department of Neurosci- ing spaces for simulation, open lounges for study, and ence, the Department of Systems Biology, and the new- state-of-the-art anatomy classrooms. The building has est, the Department of Emergency Medicine—have been earned multiple awards for its design. The New York approved. A commitment has been made to propose Times named the building to its list of “The Best Archi- another new department—likely to be called Medical tecture of New York in 2016,” saying: “It’s what medi- Humanities and Bioethics—that will complement exist- cal schools generally aren’t: playful, welcoming, warm. ing efforts across the university.

www.columbiamedicinemagazine.org 15 The Roy and Diana Vagelos Education Center, which opened in 2016, was constructed entirely through private donations, symbolizing the school’s philanthropy successes of recent years. Enhancing the Campus and Community Gift Launches Campaign to Make P&S also has made significant progress toward creating P&S Debt-Free for Students more of a campus environment for students and the sur- rounding neighborhood, despite the dense urban setting of The 250th anniversary steering committee identified a fund-raising goal for this the medical center. For many longtime residents and fac- anniversary year: raising enough money to make P&S debt-free for students with ulty members, the changes are nothing short of dramatic. financial need. The chair of the committee, P. Roy Vagelos’54, and his wife, Diana, New plantings on Haven Avenue, the addition of a have made a $25 million gift to launch the scholarship campaign, the P&S 250th Barnes & Noble store and café, open spaces for congre- Anniversary Scholarship Challenge for Endowed Financial Aid. Their gift will be gating, and renovation of the two lower levels of Hammer used to match contributions for endowed scholarships starting at $50,000 to into a Teaching and Learning Center have given students a incentivize alumni and other friends of P&S to join this effort. sense of a more traditional campus, says Dr. Kandel. The This is the first phase in the school’s effort to raise $150 million to $200 million dean’s idea of a campus was visionary in a way that was in endowed scholarship support. Achieving this goal will enable P&S students who different from those who preceded him. “There are people need financial aid to receive scholarships instead of loans or scholarships aug- who were here for a long time, very good deans, but they mented by loans. Reducing debt will allow graduates to consider career options in didn’t think in these terms at all,” he says. “Dr. Goldman fields such as primary care, research, and community service. had the idea of a campus as a place where you could sit down and have a cup of coffee, some place where there More information about the campaign is available on the anniversary website, wouldn’t be cars. He’s slowly but surely working it out. ps.columbia.edu/250. It’s very pleasant to have a campus here.” Plans for clos- ing Haven Avenue to traffic to provide a pedestrian plaza with tables and chairs are moving through government approvals, but the medical center’s one-day closings of the mittee. Endowment funds should ease those decisions. avenue for special events during the past few years have “That’s a dream of many of the faculty and alumni.” given the medical center community and the neighbor- Plans also call for continuing to build stronger relation- hood a glimpse of a new kind of campus. ships with the local community. One idea on the table is With many of the medical center’s buildings dating to an office of service learning that would help faculty and the 1920s, the physical plant has needed updating, one students formalize work with the community. Dr. Gold- of Dr. Goldman’s major goals. He is proud of putting in man also intends to enhance existing programs, including place plans that have renovated hundreds of thousands of square feet of space, along with fixing elevators, stair- wells, bathrooms, and corridors, making things look bet- P&S and the 250th anniversary planning ter even in buildings nearing the age of 100. committee have set as a top fund-raising goal Dr. Goldman’s aggressive program to replace, augment, and improve the facilities, says Dr. Vagelos, included adding something that will truly set P&S apart from its the latest technology for teaching and identifying multiple peers: eliminating medical student debt. spaces for group instruction. Another new initiative will be to “blow out” the fortress-like exterior wall of the Alumni Auditorium to create additional areas for students to social- those that encourage high school students to pursue science ize, connect their computers, or work in small groups. careers and underrepresented minority college students to consider careers in health care fields, including research. Future Priorities—and a Bold Goal The progress made in the past decade has given P&S a No discussion of the past—even of the past decade, just clear sense of optimism about the future and the likelihood a mere 4 percent of the medical school’s 250-year his- of continuing to connect strategies with goals. Noting that tory—is complete without looking toward the future. many at P&S could go elsewhere to teach, study, and work While innovations in clinical care, research, and educa- if they wished, Dr. Goldman emphasizes that one of his key tion and investment in the campus and neighborhood are roles is to offer opportunities that help people to thrive. “I sure to continue, P&S, together with a committee plan- believe the role of the dean is to create an environment that ning the 250th anniversary, has identified as its top goal allows people to be successful. It’s about how people who something that will truly set P&S apart from its peers: really do things at a world-class level every day want to eliminating medical student debt. be here, can thrive here, and can say this is the best place The cost of medical education has an effect on choices for them and their careers. We need to create, sustain, and medical students make when they consider their careers, enhance an environment that makes them not just want to

IWAN BAAN IWAN says Dr. Vagelos, who chairs the anniversary steering com- be here, but also proud to be here.” v

www.columbiamedicinemagazine.org 17 1767 1770: King’s College King’s College establishes the awards first MD second medical degree in the school in the 13 Colonies P&S HISTORY: 13 Colonies (to Robert Tucker) Samuel Bard, Years the first dean Organizational Milestones

1888 1894 1908 1917 P&S extends the Nobel Peace George Crocker P&S admits it first course of study to Laureate John R. donates $50,000 women students, three years (it was Mott founds what to P&S for thanks to the extended to would become the cancer research, efforts of Gulli four years in 1894) P&S Club, the most inaugurating a Lindh Muller, a comprehensive formal study Barnard College student activities of the disease graduate 1891 organization in at Columbia P&S and Columbia American medical medical school education fully merge

1967 1986 1993 P&S celebrates its bicentennial with Lucille Shapiro, PhD, The White Coat Ceremony, the first a three-day symposium on genetics becomes the first of its kind in the United States, and development with participants that woman to chair a welcomes incoming P&S students included Nobelists Watson and Crick P&S department. to the medical profession and other Nobel Prize winners She was recruited from Albert Einstein College of Medicine, where she chaired molecular biology, to be chair of microbiology at P&S.

18 ColumbiaMedicine Spring/Summer 2017 1807 1814 1884 A rival medical After years of William Henry Vanderbilt donates school, the College decline, Columbia’s land on 59th Street, between Ninth of Physicians and medical school faculty and 10th avenues, and $300,000 Surgeons, is founded join the College for a new P&S building, a record- by a charter from of Physician and setting gift to a medical school the New York State Surgeons on Barclay Board of Regents Street near City Hall

1922 1928 1931 1947 Edward S. Harkness and his mother, The new $25 million Bard Hall, the first Mary Imogene Bassett Mrs. Stephen Harkness, donate Medical Centre—the P&S dormitory, opens Hospital in Cooperstown, 22 acres in Washington Heights to “largest and most modern N.Y., becomes the first P&S Columbia and Presbyterian Hospital as in the world”—opens after teaching affiliate outside a site for a new medical center an Oct. 12 dedication New York City

2000 2003 2016 Columbia Trustees Columbia’s four health sciences schools The Roy and approve making the and the biomedical sciences programs Diana Vagelos nursing and public of the Graduate School of Arts and Education health schools Sciences are united under a new name, Center is separate faculties Columbia University Medical Center dedicated from the medical school (the dental faculty separated from the Faculty of Medicine in 1959)

NEXT ISSUE: Scientific and medical www.columbiamedicinemagazine.org 19 contributions throughout history TEST YOUR PAST * QUOTIENT *P&S TRIVIA (HISTORICAL TIDBITS YOU MAY—OR MAY NOT—KNOW ABOUT COLUMBIA P&S) // ILLUSTRATIONS BY PETER RYAN

3. Which of these individuals was not among the first faculty members of Columbia’s medical school? ____ Samuel Clossy ____ Peter Middleton ____ John Jones ____ James Smith ____ David Hosack ____ John Tennent ____ Samuel Bard

4. Which of these individuals did not lead an institute or center at the National Institutes of Health? ____ Harold Varmus ____ Donald Lindberg 1. Which of these individuals was not ____ Herbert Pardes depicted on a postage stamp? ____ Gerald Fischbach ____ Virginia Apgar ____ Joshua Gordon ____ Charles Drew ____ Audrey Penn ____ Walker Percy ____ Robert N. Butler ____ Edward Trudeau ____ Richard Masland

2. For whom are these eponyms associated? Crohn’s disease Apgar Score The Whipple procedure Huntington disease Goldman Index Drew Medical School Jacobi Medical Center Quimby rules Chargaff rules

20 ColumbiaMedicine Spring/Summer 2017 5. Match the years in which these advancements in medical training were instituted at P&S: entrance examinations 1770 written final examinations 1911 integration with a teaching hospital 1841 college clinic 1888 instruction in physiology 1880 first MD awarded 1811

6. Disputes in the early 1820s among the P&S faculty over standards for medical education led to which of the following: ____ a duel ____ the wholesale resignation of the P&S faculty ____ a riot outside the doors of New York Hospital

7. Name the women who match these firsts:

First full professor at P&S

______

First chair of a clinical department at P&S

______

First chair of a basic science department at P&S

______

First African-American female graduate

______

First woman to intern in surgery at Presbyterian Hospital

______

First woman to be chief resident in medicine at Presbyterian Hospital

______

First woman to graduate from P&S

______

www.columbiamedicinemagazine.org 21 TEST YOUR PAST * QUOTIENT

10. What is the five-year survival rate for people with pancreatic cancer who undergo the Whipple procedure? ____ 6 percent ____ 20 percent ____ 25 percent 8. Which of these individuals did not compete in an Olympics? ____ Benjamin Spock’29 ____ John Lattimer’38 ____ Stephen Rerych’75 ____ Jennifer Thompson’06 ____ Valeria Silva Merea’12

9. How many individuals have served in the role of dean (or equivalent) since 1767? ____ 15 ____ 23 ____ 25 ____ 41

11. Which class had a role in the beginning of the residency match system? ____ 1949 ____ 1952 ____ 1953 ____ 1960

12. Which of these individuals has not been a special guest at the medical center? ____ Bob Hope ____ Mister Rogers ____ Ann Landers ____ Alan Alda

22 ColumbiaMedicine Spring/Summer 2017 13. Match these medications with the Columbia researchers credited with the science that made the drugs possible:

Bacitracin Hattie Alexander

Rhogam Laszlo Z. Bito tPa Balbina Johnson and Frank Meleney

Xalatan/latanoprost Tracy Putnam and H. Houston Merritt

Dilantin Sherie Morrison

Meningitis treatment Richard Axel and Saul Silverstein

ReoPro and Remicade John Gorman and Vincent Freda

14. Match the names of these P&S scientists or alumni with the year in which they were awarded Nobel Prizes:

1956 Richard Axel & Linda Buck

1976 Baruch Blumberg’51

1989 Andre Cournand & Dickinson W. Richards’1923

1990 Eric Kandel

2000 Robert Lefkowitz’66 Answers appear on the following pages. 2004 E. Donnall Thomas Bonus Question: 2012 Harold Varmus’66 In the medical school’s first graduation ceremony, Samuel Bard called for creation of a public hospital to provide clinical instruction for medical students. Which New York City hospital was 15. What innovation allowed longtime P&S Professor of Ophthalmology Ramon founded as a result of Dr. Bard’s address? Castroviejo to perform the first successful human corneal transplant in 1933? ____ creating a rectangular rather than circular “window” in the cornea Submit answers via email to ____ development of techniques to preserve corneas for transplant [email protected] ____ discovery of hyaluronic acid and its molecular structure

www.columbiamedicinemagazine.org 23 1. and Stroke until 1968, when he became profes- Novelist Walker Percy (“The Moviegoer”) is the sor and chair of neurology at P&S. answer. Virginia Apgar’33, who developed the Apgar score still used to assess newborn health, was featured on a 20-cent stamp in 1994. 5. Charles Drew’40 Med ScD, a pioneer of blood First MD: 1770, by the Medical School at banking, was featured on a 35-cent stamp King’s College, which closed during the issued in 1981. Edward Trudeau’1871 was fea- Revolutionary War and reopened in 1784 as tured on a 76-cent stamp issued in 2008. Columbia College

Instruction in physiology: 1811, under the 2. purview of John Augustine Smith, recipient of Burrill Crohn’1907 an honorary MD from P&S and president of Virginia Apgar’1933 the College from 1831-1843 Allen O. Whipple’1908 TEST YOUR George Huntington’1871 College clinic: 1841, Willard Parker, MD, profes- * Lee Goldman (current dean) sor of surgery, brought patients to the school so Charles Drew’1940 Med ScD students could witness diagnosis and treatment; PAST Abraham Jacobi (faculty member, 1870-1902) on occasion, treatment included minor surgery; Edith Quimby (faculty member, 1942-1960) in 1843, the program was expanded to include QUOTIENT Erwin Chargaff (faculty member, 1935-2002) women and children patients Written final examinations: 1880; degree THE ANSWERS 3. candidates were required to pass exams in all David Hosack was not among the faculty seven departments of the college: anatomy, when Columbia’s medical school opened in physiology, chemistry, materia medica, obstet- 1767. Dr. Hosack was one of the original fac- rics, surgery, and practical medicine ulty members in the independent College of Physicians and Surgeons that opened in 1807. Entrance examinations: 1888, to demonstrate proficiency in English, Latin, arithmetic, algebra, and geometry. In the same year, the 4. course of study was expanded to eight-and-a- They all did—or do, in the case of Joshua Gor- half months annually for three years. don. A psychiatry faculty member since 2004, Dr. Gordon became director of the National Teaching hospital: 1911, when Columbia and Institute of Mental Health in 2016. Harold Presbyterian Hospital signed an agreement to Varmus’66, at different times, directed the NIH form a medical center in which the medical and the National Cancer Institute. Donald school and the teaching hospital would share Lindberg’58 directed the National Library of land donated to build a new medical center. Medicine for 31 years. Herbert Pardes directed Columbia-Presbyterian Medical Center did the National Institute of Mental Health before not open until 1928, but Columbia started joining P&S in 1984 to chair psychiatry (later appointing hospital professional staff as soon becoming dean of P&S). Gerald Fischbach was as the 1911 agreement was signed. director of the National Institute of Neurologi- cal Disorders and Stroke before becoming dean in 2001. Audrey Penn’60, professor emeritus of 6. neurology, was acting director of the National The answer is a mass resignation of the faculty. Institute of Neurological Disorders and Stroke Disputes among faculty and the school’s during two periods (January to July 1998 and trustees over the cost and quality of medical 2001-2003). The late Robert Butler’53 was education at P&S culminated in 1826 with founding director of the National Institute on the resignation of President Wright Post, MD, Aging. Richard Masland was director of the who left with the entire faculty, taking their National Institute of Neurological Disorders equipment and supplies and most of the

24 ColumbiaMedicine Spring/Summer 2017 student body. They established what would First African-American female graduate become Rutgers Medical College. The trustees Agnes O. Griffin’23 then appointed Professor John Watts, MD, to lead P&S. David Hosack, MD, former First woman to intern in surgery at chair of obstetrics and the diseases of women Presbyterian Hospital and children and an instigator of the faculty Virginia Kneeland Frantz’22 insurrection, challenged Dr. Watts to a duel over the dispute. The duel was narrowly First woman to be chief resident in medicine averted when Dr. Watts publicly apologized for at Presbyterian Hospital his role in Dr. Post’s resignation. Though duels Abbie Ingalls Knowlton’42 were common practice in New York at the time, the state legislature banned the practice a year First woman to graduate from P&S after Hosack had challenged Watts. The riot The first class of women (11 in all) entered in happened 38 years earlier, in 1788, when a mob 1917. The first to graduate, in 1921, were Emma formed outside New York Hospital (a section Corwin (ranked No. 5 in the class), Dorothea had remained open after a fire damaged much Curnow, Susanna Haigh (ranked No. 3 in the Benjamin Spock’29 of the hospital) to protest the illicit procurement class), Elizabeth Hubbard, May Mayers, Gulli of bodies from local graveyards for physicians Lindh Muller (ranked No. 1 in the class), and who gave private anatomical instruction. Elizabeth Wright. Drs. Lindh Muller and Corwin medals for swimming at the 1968 Summer were the first women to intern at Presbyterian Olympics in Mexico City. Another swimmer, Hospital on 70th Street. Dr. Lindh Muller is Jennifer Thompson, is one of the most deco- 7. credited with opening the doors of P&S to rated Olympians in history. She won 12 med- First full professor at P&S (in 1949) women. She and the dean of Barnard lobbied als, including eight gold medals, in the 1992, Virginia Apgar’33, Anesthesiology Samuel Lambert, P&S dean, who was adamant 1996, 2000, and 2004 Summer Olympics. that women should not be admitted. Among his Also a swimmer, Valeria Silva Merea competed First chair of a clinical department at P&S objections: no suitable rooms and the need for for her native Peru in the 2004 Olympics in (in 1995) Margaret Wood, Anesthesiology changes in plumbing. However, he said that if Greece and the 2008 Olympics in Beijing. $50,000 could be raised to make the improve- John Lattimer was a noted athlete, but he did First chair of a basic science department ments in the physical plant, he might consider not compete in an Olympics; after he died, at P&S accepting women. Dr. Lindh Muller contacted his daughter found a letter inviting him to the Lucille Shapiro, chair of microbiology from everyone she knew and collected a few hun- 1936 Olympics, an invitation he apparently 1986 to 1989 dred dollars. The Barnard dean collected a few turned down to continue his studies at P&S. thousand, but they were far from the goal. After further negotiations, Dr. Lambert relented and admitted 11 women. Soon after, according to Dr. 9. Lindh Muller’s obituary, “a telegram came say- The answer is 23. That count includes interim ing that an old gentleman in Texas would give deans and medical school leaders who had the $50,000.” Shortly before the first women other titles, such as president, a title the Col- were to graduate in 1921, Columbia President lege of Physicians and Surgeons that opened in Nicholas Murray Butler asked the dean at the 1807 used instead of dean. time, William Darrach, for information about the first women to graduate and “the significance of this for the development of women’s part in 10. medicine.” Dr. Darrach responded, “One strik- The answer is 25 percent. Also known as pan- ing thing has been their attitude towards special creaticoduodenectomy, the Whipple procedure privileges; they have not only not asked for it but is named for Allen Whipple’1908, a profes- refused to accept it when it was offered.” sor of surgery at P&S from 1921 to 1946. In 1935, Dr. Whipple became the first American to perform the operation, in which a surgeon 8. removes the head of the pancreas, as well as Benjamin Spock won a gold medal in the 1924 the duodenum, a portion of the common bile Abbie Ingalls Knowlton’42 Olympics in Paris as a member of the Yale duct, gallbladder, and sometimes part of the crew team. Stephen Rerych won two gold stomach, and then reconnects the remaining

www.columbiamedicinemagazine.org 25 12. discoveries concerning new mechanisms for the Alumni The answer: Mister Rogers has not been a origin and dissemination of infectious diseases” special guest (as far as we can tell). At the 50th News anniversary of the Edward S. Harkness Eye 1989, Physiology or Medicine: Harold E. Institute in 1984, Bob Hope was given an hon- Varmus’66 (and J. Michael Bishop) “for orary Doctor of Humane Letters degree. Ann their discovery of the cellular origin of Landers (real name Eppie Lederer) received an retroviral oncogenes” award in 1992 from the Columbia-Presbyterian Health Sciences Advisory Council. Alan Alda 1990, Physiology or Medicine: Former phy- Allen O. Whipple, center, with the Department delivered the P&S graduation speech in 1979, a sician-in-chief at the Mary Bassett Imogene of Surgery, 1928 speech that is still occasionally requested. Hospital in Cooperstown, E. Donnall Thomas, (and Joseph Murray) “for their discoveries intestine, bile duct, and pancreas. Only concerning organ and cell transplantation in 20 percent of people with pancreatic cancer the treatment of human disease” are eligible for the Whipple procedure, which boosts their five-year survival rate from just 2000, Physiology or Medicine: University 6 percent to 25 percent. Professor Eric Kandel (and Arvid Carlsson and Peter Greengard) “for their discoveries concerning signal transduction in the nervous system” 11. The Class of 1952 was the first to participate 2004, Physiology or Medicine: University Pro- in the National Resident Matching Program fessor Richard Axel and former postdoc Linda for appointments to medical residencies. The Buck “for their discoveries of odorant receptors class not only participated in “The Match”; and the organization of the olfactory system” it also played a leading role in improving it before it started. The match program was 2012, Chemistry: Robert Lefkowitz’66 (and created to replace an unregulated process by Brian Kobilka) “for studies of G-protein-cou- which hospitals recruited the best graduates as pled receptors” interns with methods that sometimes included bribery. Before the match program was devel- Balbina Johnson oped, some hospitals sought commitments 15. from students as early as their second year The answer is a rectangular incision. Spanish of medical school. The class felt the original 13. emigré Ramon Castroviejo, MD, described computer matching program gave hospitals an Bacitracin: Balbina Johnson and his 1935 corneal transplant, perfected at edge over the interns. Said Jack G. Shiller’52 in Frank Meleney Columbia-Presbyterian, at the 1937 American an article in the Winter 1985 issue of this mag- Rhogam: John Gorman and Vincent Freda College of Surgeons meeting in Chicago. His azine: “Certain troublemakers from Harvard, tPa: Richard Axel and Saul Silverstein talk detailed how the edges of his rectangular P&S, and Hopkins met, went back to their Xalatan: Laszlo Z. Bito incisions could be fitted better to merge with schools, raised funds ... and sent a long tele- Dilantin: Tracy Putnam and H. and become a living part of the rest of the eye. gram to the president of the graduating class Houston Merritt The following year, Dr. Castroviejo launched a of every medical school in the country. As a Meningitis treatment: Hattie Alexander campaign urging Americans to will their eyes result of this effort, a meeting was held in Bard ReoPro and Remicade: Sherie Morrison to science, leading to the creation of present- Hall attended by representatives of every medi- day eye banks. Biochemist Karl Meyer discov- cal school, the deans of many major medical ered hyaluronic acid in 1935, two years after schools, and representatives of the American 14. he joined the Department of Ophthalmology Hospital Association, the Matching Plan, and 1956, Physiology or Medicine: Andre Cour- as a German refugee. His body of work was other interested organizations. The students nand and Dickinson W. Richards’23 (and recognized in 1956 with the Lasker Award. threatened to boycott the program unless the Werner Forssmann) “for their discoveries con- Japanese ophthalmologist Dr. Saiichi Mishima officials attended the meeting.” After that cerning heart catheterization and pathological spent three years at P&S in the late 1960s; his meeting, the program was changed so that a changes in the circulatory system” research at the time, investigating the corneal graduate would match with the hospital high- endothelium and its pump function, yielded est on his or her preference list that offered 1976, Physiology or Medicine: Baruch Blum- vital techniques for enhanced preservation of that student an internship. berg’51 (and D. Carleton Gajdusek) “for their donated corneas.

26 ColumbiaMedicine Spring/Summer 2017

Class co-chairs Robert Baratta’66 and Henry Spotnitz’66 Marianne Wolff’52, Alumni News Editor Alumni Peter Wortsman, Alumni News Writer Additional class notes by News&n o t e s Bonita Eaton Enochs, Editor

1948 tive, and how surgical procedures tection throughout certain surgical literature led to the discovery that Reflecting on nearly seven decades could be bettered.” Joe credits procedures. This was adjuvant once before, in 1827, chikungu- since starting his career as a gen- that response with improving his therapy, used in combination with nya invaded the New World.” He eral surgeon, Joseph M. Bennett own approach to patient care. standard protocols of oral and described that in a 2015 paper in has come to learn that the practice “It led me to more effective treat- parenteral antibiotics, but he said Emerging Infectious Diseases titled of clinical medicine is both science ments and methods. In fact, mak- that in his experience, the method “Reappearance of Chikungunya, and art. “From the theoretical ing reflection a habit seemed to significantly lowered surgical site Formerly Called Dengue, in the to the practical, I learned that become a ‘force’ that empowered infection. “What this all leads me Americas,” which can be found medicine was necessarily open to and broadened the ramifica- to is to recommend that P&S initi- online by searching Scott’s name at tions of each patient’s illness.” ate a program to train its medical www.cdc.gov/eid. He stresses that innovation and students to reflect, imagine, and advancement in medicine can orig- innovate,” Joe writes. “Whether 1957 inate almost anywhere—the office, the graduates practice at P&S or Peter G. Wilson trained as a psychia- the clinic, a community hospital, in community hospitals in urban, trist and has been at Weill Cornell or other treatment center. Joe says suburban, or rural locales or Medical College since 1958, teach- that taking time and reflecting whether they are providing clinical ing, doing research in amputation allowed him to conceive a variety care or working in the laboratory, and kidney transplantation, taking of original surgical techniques. He they will benefit—as I did and care of patients in inpatient, outpa- personally designed a new instru- others before me—in taking time tient and consultative venues, and ment for common duct explora- to think about how to practice filling administrative roles. Now tion, which he reported in a paper medicine better.” The full text of professor emeritus in clinical psy- published in the New York State the essay by Joe, who now lives chiatry, Peter still teaches and men- Medical Journal in 1958. In 1965 in Brookville, Long Island, can be tors “to keep myself and students up Joseph M. Bennett ’48 he presented a paper at the Con- read on the P&S 250th anniver- to snuff.” Working in London, Paris gress of the American College sary website, 250.ps.columbia. and Kingston, Jamaica, he writes, further refinement and advance- of Surgeons on “Percutaneous edu/scrapbook, where you can gave him insight into other forms ments,” Joe writes in an essay he Subclavian Central Venous Cath- also submit a memory, and on the of health care, giving him hope for submitted to Columbia Medicine. eterization for Infusion or Venous Columbia Medicine website, www. some incorporation of those forms He recalls asking the chief of sur- Pressure Measurements” and pub- columbiamedicinemagazine.org. into the American system. “Some- gery at Lincoln Hospital, where lished “Fixation of the Posterior times this moved forward and now Joe was chief resident, how he Gastric Wall in Esophageal Hiatus 1955 is regressing, but our students are spent his downtime and his time Herniorrhaphy” in the American Scott B. Halstead had two recent still passionate and idealistic, so I commuting between hospitals. Surgeon. In 1972 he published scientific papers published that do not give up hope. I had hoped “His answer was unexpected and “Modified Bancroft Procedure for describe research work he has done that by now our health care system had a lasting impact. He empha- the Difficult Duodenal Stump” in over the years since his graduation would be more inclusive and am sized that he would think about the Archives of Surgery. He also from P&S. His life, he says, was horrified that it is regressing. Despair his patients and focus on how he writes about beginning to use, in unalterably changed in 1961, when is not an option and we must work could improve all aspects of their 1975, cefoxitine-soaked lap pads he was assigned by the U.S. Army and hope.” Peter and his wife, care, whether pre- or postopera- for constant topical antibiotic pro- to establish a virus lab in Bangkok. Nancy, raised three children who While there, he started studies on have married and provided them a scientific hobby described in a with six grandchildren—“all marvel- paper, “Epidemiology of bladder ous.” Peter and Nancy celebrated send your news via mail, fax, or email: stone of children: precipitating their 50th wedding anniversary Mail: Bonita Eaton Enochs, Editor events.” The paper can be found by taking 21 family members to a Columbia Medicine online by searching the title at villa in Rincon, Puerto Rico. Look- College of Physicians & Surgeons link.springer.com. His main work ing back on his education (he also 630 W. 168th St., Box 153 in Thailand was to study dengue graduated from Columbia College), New York, NY 10032 and chikungunya virus infections, Peter expresses gratitude to Profes- Fax: 212-305-4521 and he was in Thailand in 1963 sors Guttman and Stein at Columbia when the chikungunya virus spread College and Drs. Loeb, Aranow, and Email: [email protected] from East Africa to the Indian Hanger at P&S “for their wisdom, subcontinent. “My reading of the intellectual rigor, and kindness.”

www.columbiamedicinemagazine.org 27 Alumni News&n o t e s

radical prostatectomies (5 percent, geons during the organization’s 53rd 2013-2014) in the southern San annual meeting. Eric is best known Joaquin Valley after the USPTF deci- for making history in 1984 when he sion about PSA. “New York general performed the world’s first successful practice has done much better with pediatric heart transplant. Since that a 35 percent reduction,” he adds. landmark achievement, he has con- tinued to study and improve cardiac Robert P. Lisak serves as the Parker surgical care in children and adults. Webber Chair in Neurology at Wayne Much of his research has focused on State University School of Medicine. the management of end-stage heart He was editor of the Journal of the disease using artificial circulatory Neurological Sciences, the official support. He serves as vice chair of journal of the World Federation of the NIH-supported Cardiothoracic Robert Scott’61 Alfred Scherzer’63 Neurology, from 1997 to 2013. He Surgical Trials Network and works also has served as chair of the Depart- with industry on discoveries related 1961 disabilities in the New York City ment of Neurology and neurologist- to smallpox, Alzheimer’s disease, and Robert Scott spent most of his schools and developed international career as a member of the Abbott pediatric resident training in Cambo- Northwestern Hospital medical dia. He has become a leader in global staff in Minneapolis. Having been studies of early identification and chief-of-staff and a member of the intervention for children with dis- Board of Trustees of Abbott North- abilities. He has captured his journey western Hospital, he has firsthand in a memoir titled “Taking on Global knowledge of the changes that Health Issues/Odyssey of a Develop- resulted in the evolution of two sep- mental Pediatrician.” Read about the arate institutions—Abbott Hospital book in this issue’s Alumni in Print. (named for Amos Wilson Abbott, “I invite my classmates to peek in who graduated from P&S in 1869) and see where my travels have taken and Northwestern Hospital for me,” Alfred says. Women and Children—that merged Robert P. Lisak’65 Eric A. Rose’75 to become Abbott Northwestern. 1965 His new book on the history of Anthony H. Horan, who has a urol- Abbott Northwestern is described ogy practice in California, writes: in-chief at the Detroit Medical Center. graft versus host disease. After more in this issue’s Alumni in Print. “Lest you think that the class of At the University of Pennsylvania, he than 25 years at P&S, Eric joined 1965 has gone to sleep, let me was vice chair of neurology and an Mount Sinai, where he chaired the 1963 report my recent activities: In late associate member of the Neurosci- Department of Population Health Sci- When Alfred Scherzer was first October, I continued my record ence Institute. The second edition of ence and Policy from 2008 through rejected from medical school after of unbroken (since 1994) submis- “International Neurology,” a book 2013 and where he remains a profes- college, he turned to international sions to the Western Section of the he edited, is described in this issue’s sor of population health science and work. Now, after five years of inter- American Urological Association Alumni in Print. policy. He also is executive chairman national public health work in South- meeting in Hawaii, with four posters of SIGA Technologies, a biotech affili- east Asia and the South Pacific with and a three-minute ‘useful trick’ pre- 1974 ate of MacAndrews & Forbes. The the U.S. Public Health Service and sentation from the podium. Two of Steven Schwarz received the Mur- Earl Bakken Scientific Achievement WHO and 50 years as a develop- the posters were about enuresis. One ray Davidson Award for 2016 Award, established in 1999, is named mental pediatrician, Alfred retired in described the overlooked diagnosis from the American Academy of for the man who developed the first March 2016. His accomplishments of spina bifida occulta as a cause Pediatrics. He is professor of pedi- wearable artificial pacemaker. include creating permanent orga- of refractory enuresis in late child- atrics at SUNY Downstate Medical nized government health education hood. A second described a cure of Center and director of the Division 1977 services in Burma and Ceylon. After enuresis by dilatation of a ‘pin hole’ of Gastroenterology, Hepatology Harvey Makadon, director of the becoming a physician, he established ureteral meatus in a large uretero- and Nutrition at the Children’s National LGBT Health Education developmental pediatric services at cele over one month with a double-J Hospital at Downstate. Center and the National Center for Weill Cornell Medical College, where ureteral stent.” In late January Innovation in HIV Care, was chosen he is now clinical professor emeritus 2017, Tony presented a poster to the 1975 to receive an honorary degree from of pediatrics. Also during his career, 27th International Prostate Cancer Eric A. Rose received the 2017 Earl Rutgers University at its 251st com- he helped organize special education Update at Beaver Creek, Colo., Bakken Scientific Achievement Award mencement in May. Harvey, who also services for children with multiple that illustrated the slow attrition of from the Society of Thoracic Sur- is director of education and training

28 ColumbiaMedicine Spring/Summer 2017 Read the latest e-newsletter for alumni at www.columbiamedicinemagazine.org/webextras

programs at the Fenway Institute and was named to the executive commit- formations Clinic at Massachusetts and Stamford, Conn.—are affiliated a professor of medicine at Harvard, tee of the American College of Rheu- General Hospital. A textbook with Greenwich Hospital. Letters was honored for devoting his career matology as secretary, placing her Aaron edited is described in this of recommendation submitted on to providing and promoting care for in ascension to become president in issue’s Alumni in Print. Mark’s behalf referenced his com- the poor, the homeless, patients living 2019 after serving as secretary and mitment to providing the highest with HIV, and members of the les- president-elect. Ellen is the Myles J. 1996 MD/PhD quality of medical care for his bian, gay, bisexual, transgender, and McDonough Chair in Rheumatol- Frank S. David is founder and patients and seeking optimal out- queer community. ogy, professor of medicine, and chief managing director of a biotech comes for them through surgical and of rheumatology at the University consulting firm, Pharmagellan. See nonsurgical techniques. Mark also 1978 of Massachusetts. Alumni in Print to read about his has a master’s degree in public health Henrietta Robin Barnes is an new book, a guide to biotech finan- from Columbia. After residency assistant professor of medicine at 1983 cial modeling. Before founding training at Columbia, he completed Harvard Medical School and has After 27 years at the University Pharmagellan in 2013, Frank was a fellowship in hand surgery at the been practicing medicine for more of Maryland School of Medicine, director of strategy in AstraZene- Mayo Clinic in Rochester, Minn. than 30 years, including 27 years Michael Donnenberg moved to the ca’s oncology innovative medicines as a primary care internist at Cam- Virginia Commonwealth University unit and, earlier, a director in the 2009 School of Medicine in Richmond, Jacob M. Appel has another Va., as senior associate dean for new book featured in this issue’s research and research training. In Alumni in Print, adding to his list addition to overseeing the medical of creations that includes literary school’s research efforts, he will novels, short story collections, have oversight of the MD-PhD, stage plays, and essays. Many of PhD, and postbaccalaureate, pre- his books and short stories have medical, and predental certificate been honored with prominent book programs. He continues his own awards, and his plays have been research on the pathogenesis of performed in New York, Philadel- enteric infections and plans to phia, Tulsa, Detroit, Columbus, continue his practice in infectious Indianapolis, Pittsburgh, New Lon- diseases and teaching medical don, and other cities. An author, school students in preclinical and physician, attorney, and bioethicist, Henrietta Robin Barnes’78 Frank S. David’96 MD/PhD clinical settings. Jacob has degrees from Brown, Harvard, NYU, and Albany Medi- bridge Health Alliance. See Alumni 1993 consulting arm of Leerink Part- cal College—in addition to his in Print to read about her book, Aaron Fay has authored more ners. A board-certified pathologist, P&S MD degree. He is assistant “Hijacked Brains: The Experience than 100 articles and textbook he also works as an innovation professor of psychiatry at Mount and Science of Chronic Addiction.” chapters on eyelid and orbital strategist at the Brigham Research Sinai School of Medicine and an surgery. He currently serves as an Institute of Brigham and Women’s attending physician at Mount Sinai 1981 assistant professor of ophthalmol- Hospital. He blogs about biomedi- Hospital and Beth Israel Hospital. Ellen Gravallese has been appointed ogy at Harvard Medical School cal innovation at Forbes.com. He also teaches at the Gotham an associate editor of the New Eng- and is a founding member of the Writers’ Workshop. land Journal of Medicine. She also Hemangioma and Vascular Mal- 2006 Mark A. Vitale received the Dr. 2011 Melville G. Magida Award at the The Duluth Family Medicine Resi- Fairfield County Medical Associa- dency Program in Duluth, Minn., tion’s annual meeting in October hired James Conniff as a faculty 2016. The Magida Award has been physician and board-certified fam- presented annually since 1980 to a ily doctor. Jamie completed his young practicing physician in Fair- residency in family medicine and field County, Conn., who exhibits a community health and a fellow- sense of genuine care and concern ship in research at the University for patients. Mark is a board-certi- of Wisconsin in Madison. He also fied orthopedic surgeon who special- earned a master’s degree in pub- izes in the diagnosis and treatment of lic health from Wisconsin. Jamie hand, wrist, and elbow conditions. joined the Duluth program after

Ellen Gravallese’81 Aaron Fay’93 He and his practice—Orthopaedic & practicing at Northeast Family Neurology Specialists in Greenwich Medical Center in Madison.

www.columbiamedicinemagazine.org 29 Alumni News&n o t e s

alumni in print By Bonita Eaton Enochs, Editor

Abbott Northwestern Hospital: college, Dr. Scherzer went on a 10-year hiatus A Celebrated History in Southeast Asia and the South Pacific. This Robert Scott’61 experience turned out to be a blessing in dis- Abbott Northwestern guise and led him to a unique medical career in Hospital Foundation, 2016 developmental pediatrics, long before this field had a recognized professional status. Dr. Scher- In 1877, Dr. Amos Abbott (an 1869 P&S zer’s story illustrates a strong positive reaction graduate) rented a small house in Minneapo- to perceived failure and how time, persistence, lis to treat his patients. By 1902, his practice and luck combined to enable him to fulfill his moved to larger accommodations, known as childhood dream of becoming a physician. Abbott Hospital. Meanwhile, in 1882, Min- neapolis community leader Harriet G. Walker gathered 44 women and rented a house they International Neurology, called Northwestern Hospital for Women and 2nd Edition Children. In 1970, the two hospitals merged Robert P. Lisak’65 to become Abbott Northwestern Hospital. Dr. Wiley-Blackwell, 2016 Scott, a former member of the Abbott North- western Hospital medical staff, brings in this This unique textbook by a team of editors new book the fascinating history of the two led by Dr. Lisak deals with the variations in great institutions that had been delivering health the causes, presentations, and treatment of care in Minneapolis for more than a century. neurological disease throughout human popu- lations by presenting international authorship that distills expert knowledge from around Taking On Global Health Issues/ the world, including developing nations. Odyssey of a Developmental Consisting of 22 sections and 173 chapters Pediatrician with contributions from worldwide experts, Alfred Scherzer’63 it serves as an invaluable guide for physicians Ra Press, 2016 to expand their knowledge of different neu- rological disorders in different countries. This Dr. Scherzer shares in this book his story of is the first book to take a global approach to failure and success. Frustrated at failure to neurological illness, and it has been endorsed gain acceptance to medical school following by the World Federation of Neurology.

30 ColumbiaMedicine Spring/Summer 2017 Hijacked Brains: The Experience by incorporating the perspectives of numerous The Mask of Sanity and Science of Chronic Addiction specialties. The book covers the clinical presen- Jacob M. Appel’09 Henrietta Robin Barnes’78 tation, pathophysiology, natural history, and The Permanent Press, 2017 Dartmouth College Press, 2015 management alternatives of disease processes affecting the orbit, eyelids, lacrimal system, In his new dark and unsettling novel, Dr. By interweaving personal narratives with fasci- and upper face. The book uses an easy-to- Appel delves into the mind of Dr. Jeremy nating recent studies in brain science, Dr. Barnes follow template format throughout for quick Balint. On the outside, Dr. Balint is a pillar of shows how addictive drugs overtake basic brain and easy navigation and features more than the community; he is the youngest divisional functions and transform them to create a chronic 1,200 high-quality clinical images, histological chief at his hospital, a model son to his elderly illness that is very difficult to treat. The book illustrations, and imaging photos that provide parents, and fiercely devoted to his wife and explores how the healthy brain works, what it clear visual examples of orbital disease. two daughters. On the inside, he is a high feels like to be crippled by addiction, and how functioning sociopath who reveals the depth American culture tends to blame the addict of his cold-blooded depravity. One editorial for bad choices and personal weakness. One The Pharmagellan Guide to Biotech review said, “Appel’s characters have plenty reviewer praised Dr. Barnes for “capturing the Forecasting & Valuation of secrets to keep; Dr. Balint is not a man try- complexity and anguish of the chronic illness Frank S. David’96 MD/PhD ing to overcome his demons, but one who is of addiction with clarity and compassion. She Pharmagellan, 2017 fully in league with them, and that keeps ‘The writes about complex issues with the clarity that Mask of Sanity’ moving.” comes from deep thought and rich experience.” Dr. David’s new book is a comprehensive refer- ence handbook to creating and interpreting financial models for early-stage biopharma assets Diseases and Disorders of the Orbit and companies. The book is intended to help send books (published within and Ocular Adnexa anyone—biotech executive, investor, deal maker, the past two years) to: Aaron Fay’93, Co-Editor entrepreneur, adviser, or others who aspire to be Elsevier, 2017 involved in the biotech industry—who needs to Bonita Eaton Enochs, Editor know how to build and analyze forecasts and Columbia Medicine College of Physicians & Surgeons Written by an international team of more than valuation models of R&D-stage drugs, which 630 W. 168th St., P&S Box 153 70 contributing experts from five continents they can then use to make investment decisions, New York, NY 10032 and co-edited by Dr. Fay, this new textbook pitch to potential partners or funders, or assess offers in one convenient volume an in-depth their own R&D programs. One of the book’s Send inquiries about books to and thorough approach to diagnosing and co-authors, Seth Robey, recently received his [email protected] managing orbital and ocular adnexal diseases PhD degree in pharmacology from Columbia.

www.columbiamedicinemagazine.org 31 Alumni News&n o t e s

• ALUMNI PROFILE

Fadlo R. Khuri’89: Championing Intellectual Rigor and Risk at the American University of Beirut

By Peter Wortsman PETER WORTSMAN

n 2016 the American University of Bei- Courage is definitely a required quality for rut, the oldest and arguably the most any academic leader in the Middle East. One of Irespected institution of higher learning Dr. Khuri’s predecessors at AUB, Dr. Malcolm in the Middle East, celebrated its 150th anni- H. Kerr, an American national and the third versary, a momentous occasion for any school president to be born in Lebanon, was assassi- but particularly noteworthy for an institution nated while in office, and his successor, Calvin committed since its founding to free and open Plimpton’51 MSD, faced an attempted kidnap- dialogue, critical thinking, and intellectual rigor ping. Among other pressing and unquestionably in a region of tumult. Looking ahead, the peda- courageous priorities under Dr. Khuri’s aegis is gogical challenges and opportunities remain AUB’s focus on the needs of refugees in a coun- formidable, according to Fadlo R. Khuri’89, an try with a population of 4 million that currently oncologist by training and committed educator, hosts close to 2 million refugees. AUB’s Center who took office as the school’s 16th president in for Civic Engagement and Community Ser- September 2015. vice won the 2016 MacJannet Prize for global “A full half of the population in many Arab citizenship in recognition of its educational countries is under the age of 25,” Dr. Khuri outreach to Syrian refugees. In addition, an points out. “Young people are not yet set in AUB architect, Karim Najjar, designed prefab their ways. They’re open to new ideas. The risk modules for schools for refugee children. The is that they can be turned toward ideological schools are being put into action as quickly as extremism, but they can also be influenced to they can be built. do great good.” Dr. Khuri made time for an interview at Dr. Khuri characterizes the institution, of which AUB’s New York office in September 2016, a he is an alumnus and to which he has longstand- year into his presidency. ing familial ties on both his mother’s and father’s sides, as “a beacon of openness and transparency Grounded in Cultures of Caring and secularism and a force for reason” in a coun- Born in Boston, Mass., of Lebanese émigré par- try and a part of the world splintered by rivalries ents, his father a physician, his mother a math- between conflicting religious and political fac- ematician, Fadlo Khuri moved back to Lebanon tions. “What we needed to do early on in my in 1970 and was brought up in Beirut, where term was to gain trust on all sides,” he says. Hav- he attended high school at the International ing won that trust from board members, faculty, College in Beirut and began his undergraduate students, and parents, he is seeking consensus studies at AUB. As a young man growing up to steer the school toward making a sustainable during the Lebanese Civil War, a time of acute positive impact in the region and beyond. “As a sectarian differences, he was often asked by small university, we need to take intellectual risks friends: What party do you belong to? His par- and focus on courage.” ents replied: “We belong to the party of AUB.”

32 ColumbiaMedicine Spring/Summer 2017 A history buff steeped in American culture— me at Columbia.” Another P&S mentor, the at the Winship Cancer Institute, where he was with a reverence for Abraham Lincoln as a model late Leslie Baer’63, director of the hyperten- later named the Roberto C. Goizueta Distin- leader, a lifelong allegiance to the Boston Red Sox, sion research program, under whose guidance guished Chair for Cancer Research and assem- a taste for New England clam chowder, and a can- he pursued his third-year medical rotation, bled a dynamic research team. do attitude—he is also deeply rooted in the rich “taught me how to write a thoughtful patient A widely cited molecular oncologist and cultural diversity of Lebanon and the Arab world. history, to include my reasoning, the rationale acknowledged thought leader in translational As he put it in a presentation in 2016 to AOA for a diagnosis, and plan of treatment.” medicine, the author of more than 300 peer- inductees at the AUB medical school, “I was born It was also at Columbia that he met the most reviewed articles, Dr. Khuri has focused his clin- a Lebanese, but raised intellectually by Koreans, important person in his life, his future wife, ical research on the development of molecular, Chinese, and Americans, by Christians, Moslems, Lamya Tannous Khuri, who received a PhD in prognostic, therapeutic, and chemo-preventive Jews, atheists, and communists alike.” Such diverse nutrition at Columbia in 1993. approaches to improve the standard of care for influences helped him understand from an early Another distinguished member of the P&S patients with lung and aerodigestive cancers. age “there really is no ‘other’ when you’ve figured faculty, the late John Lindenbaum, MD, at the “Committed to thinking of cancer as not just out that you yourself are part of that ‘other.’ I am time vice chair of medicine, counseled him to end-stage but taking in the entire evolution from not some preternaturally sensitive individual,” he give clinical medicine a try and recommended premalignancy in order to establish the earliest insists. “I grew up in the truly diverse environment training in medicine at Boston City Hospital. In possible intervention point in the disease,” he of AUB where people debated tough ideas and Boston Dr. Khuri faced the daunting challenge of and his team at Emory were in the vanguard tolerance of difference was the norm.” The school treating a growing cohort of patients in the early of what has come to be known as precision or admitted its first women as full-time students in days of the AIDS epidemic. Grueling as it was, he personalized medicine. the 1920s, long before Harvard, Yale, Princeton, enjoyed the immediacy of taking care of patients. and Columbia. His mother, Dr. Soumaya Khuri, “It’s easy to feel you’re working for a job your A Call to Service a professor of mathematics at AUB, was and first eight hours, but after that you need to know “The real challenge in life,” he says, “is about remains a vocal feminist. “When you bring dif- that it’s more than a job, that it’s a calling. being able to reinvent and redefine yourself every ferent people from different backgrounds together “Anybody who tells you that the physician- 10 to 15 years.” Upon learning that AUB was even in a trouble spot,” he argues, “that fear of the patient relationship is a one-way stream, that seeking a new president, Dr. Khuri, who had other starts to evaporate.” the great, noble physician gives and the patient been contemplating a career pivot, decided to He returned to the United States to earn a just takes,” he adds, “they don’t know medi- apply for the job. It was for him a chance to bachelor’s degree from Yale University and to cine, they haven’t practiced it.” In addition give back to an institution that helped shape his study medicine at P&S. “I went into medicine,” he says, “because I wanted to help people” and credits the encouragement of his father, the “We’re at a tipping point in history in the Arab world. I want late Raja Najib Khuri, MD, a renowned renal to contribute in any way I can to the shift towards a better, physiologist, professor, and chair of the Depart- sounder set of beliefs and ideologies than currently exist there.” ment of Physiology at AUB, who served as the school’s acting president shortly after the assas- sination of Dr. Kerr and from 1978-1987 as to the emotional gratification of providing character and his thinking and an opportunity to dean of the medical school. care, medicine offers an intellectual challenge. have a positive impact on a country and a culture In the AOA speech, Dr. Khuri vividly recalled “There’s something very rewarding about piec- to which he feels a strong emotional tie. “We’re his first day on clinical rounds as a third-year ing together the jigsaw puzzle of disease. Even at a tipping point in history in the Arab world. medical student at P&S. Entrusted with the care if you can’t cure someone, you’ve eased their That’s one of the biggest reasons I went back,” of a gracious rabbinical scholar dying of pancre- pain, diagnosed immediate complications, alle- he says. “I want to contribute in any way I can to atic cancer, he felt compelled to dwell on the fam- viated a symptom.” the shift towards a better, sounder set of beliefs ily’s bitter plaint: “How could such a good man He subsequently completed a fellowship in and ideologies than currently exist there.” have such a cruel and unkind death?” Ultimately, hematology/medical oncology at New England Did a career in medical oncology help pre- he added, “My search for meaning in this painful Medical Center and Tufts University School of pare him for the challenges of leading a major event drove me into the field of cancer research.” Medicine. In 1995 he joined the Department of university? “Yes, I most definitely think it has,” At P&S he came under the influence of the Medicine at the University of Texas MD Ander- he says. “First, it helps to understand that you late Bernard Weinstein, MD, professor of medi- son Cancer Center and in 2002 was recruited often have to synthesize complex and contra- cine and director of the cancer center at Colum- by Emory University as professor of hematol- dictory data to make a difficult decision. Medi- bia and Presbyterian Hospital. “Bernie was the ogy and oncology and director of the Discov- cine prepares you to accept responsibility for first person to really make science thrilling for ery and Developmental Therapeutics program that decision. It is also a very humbling profes-

www.columbiamedicinemagazine.org 33 Alumni News&n o t e s

sion; this is particularly the case in oncology. confident, more empowered to make a differ- boundaries of the health sciences to include, nota- Even though inevitably you fail a lot, you cele- ence than when they came in.” bly, issues related to conflict medicine. brate every victory and learn from every defeat. As a pedagogue Dr. Khuri is a strong believer Sometimes you don’t have the answer. So learn- in the ethos espoused by AUB’s founding presi- Mission Creates Margin ing to live with ambiguity, which I think is the dent, Dr. Daniel Bliss: “We were not anxious to In a speech titled “Legacy of Service,” delivered hallmark of a good leader, is a very key quality.” appear great, but we were anxious to lay foun- at the AUB 2016-2017 opening ceremony, Dr. dations upon which greatness could be built.” Khuri challenged the role of the university. “We Over the years, AUB has produced leaders in have strayed far too long and far too deeply a multitude of fields, including Ashraf Ghani, on the utilitarian and professional path,” he president of Afghanistan; Zaha Hadid, the first warned, a dangerous detour he perceives not woman to win the prestigious Pritzker Archi- just at AUB but at universities everywhere, at tecture Prize; Dr. Ray Irani, former chairman which the humanities have sunk to second- and CEO of Occidental Petroleum (a company rung status behind applied professional, and previously run by P&S alumnus Armand Ham- more obviously profitable, pursuits. To redress mer’1921); and Dr. Charles Malik, a diplomat this perceived failing, Dr. Khuri hopes to rein- and former Secretary of the U.N. Commission vigorate the study of philosophy, Arabic, and on Human Rights, instrumental in drafting the international literature and to restart indepen- Universal Declaration of Human Rights. dent fine arts, music, and theater departments, Dr. Khuri hopes to cultivate future leaders. among other fields of liberal study. The wave of protest movements that has come “Beirut is not a tidy city, physically or intel- to be known as the Arab Spring awakened lectually,” he readily admits, “but that lack of dreams, many of which were beaten down by tidiness is precisely why the founding fathers oppressive regimes, but the dreams did not die. of the university chose well. You want a lot of President Khuri with AUB athletes “Democracy is a very fragile entity,” he says. fertile dissonance in a rich academic environ- “It’s like one of those flowers that doesn’t neces- ment and from my perspective that dissonance Dr. Khuri says the American pedagogical sarily grow in all soil unless it’s really carefully is grounded in the humanities. model of a liberal education, as promoted by tended for a long time.” By his frank assess- “Yes, we will continue to train some of the founders of AUB, is still viable today, though ment, “statesmen and stateswomen are rare in the best engineers in the Middle East and the it may well be in need of updating. “We must the Arab world—we have never had a Lincoln world,” he says. But in response to parents and acknowledge the successes and the failures of or a Mandela, but that doesn’t mean we can’t trustees who may question the utility of what previous applications of the American intellec- help bring them to the fore tomorrow.” they perceive as impractical pursuits, he adds: tual ethos.” American political policy, he points One of his most ambitious projects as part of “I don’t want to train fewer engineers; I just out, has not always been a force for good in the university strategic plan is the creation of a want those engineers to take more humanities the Middle East. “Mistakes were made and are being made, but people in the region did not lose faith in the American intellectual agenda.” Medicine is a humbling profession, particularly in oncology, says Whereas in the United States, in Dr. Khuri’s Dr. Khuri: “Even though inevitably you fail a lot, you celebrate view, “politicians don’t take academic insti- every victory and learn from every defeat. Sometimes you don’t tutions all that seriously, except as intellec- tual factories to produce policy wonks, there have the answer. So learning to live with ambiguity, which I is a respect for and a fear of academe among think is the hallmark of a good leader, is a very key quality.” the political leaders in Lebanon and the Arab world, which is both exhilarating and a little frightening. They care about what we advocate. global health sciences center. Aiming for more courses, learn more about why we do things, as “The university cannot replace the role of the than just a traditional conglomerate of schools of opposed to just how we do things. You really Lebanese government,” he says, “but we can medicine, nursing, pharmacy, and public health, only get that chance in college, and it’s currently step up and provide the truth, whether it’s about Dr. Khuri wants AUB to take advantage of the underemphasized in the curriculum.” carbon emissions or trash burning or medicine fact that “we are at the epicenter of some major Dr. Khuri recalls a conversation he had some or history. As educators, we also can and must health crises, not just medical crises.” He hopes years ago with a member of the board of trust- take better care of our students, so that they go the center will take a leadership role in addressing ees of Emory University, an institution at which out into the world more knowledgeable, more health-related issues that transcend the traditional he spent more than a decade and a half on the

34 ColumbiaMedicine Spring/Summer 2017 Columbia’s Historic Ties to AUB

Founded in 1866 by American missionaries in Lebanon and Syria under the auspices of the American Board of Commissioners for For- eign Missions, and originally called the Syrian Protestant College, the institution later renamed American University of Beirut was, in the words of its first president, Dr. Daniel L. Bliss, open to “all conditions and classes of men without regard to color, nationality, race, or reli- gion. A man, white, black, or yellow, Christian, Jew, Mohammedan, or heathen, may enter and enjoy all the advantages…” From early on in its history, AUB had a close connection to Columbia University. Of the school’s 16 presidents to date, seven earned graduate degrees and/or taught at Columbia. Frederic P. Herter, MD, a longtime professor of surgery at P&S, served for some years, first as a mem- ber and then as chairman of the AUB Board of Trustees, before being Inauguration of AUB President Fadlo Khuri’89 with AUB Trustee named president. In his memoirs, “May I Cut In?”, Dr. Herter recalled Thomas Q. Morris’58, left, in attendance that his interest in the school had been stoked by a pre-operative con- versation with the legendary P&S surgeon Dr. Allen Oldfather Whipple, Medicine, served for many years as a member, then as chairman, of the best known for the Whipple procedure, a complex surgical procedure AUB Board of Trustees and was awarded an honorary doctor of humane to remove parts of the pancreas, the small intestine, and the gallblad- letters degree from AUB in 2009. Other Columbians have ties to AUB. der to treat pancreatic cancer. Dr. Whipple, who had been born in Iran, David Bickers, chair of dermatology at P&S, was vice chair of the Board was raised in Syria, and was familiar with Lebanon, praised AUB as of Trustees for several years. Dr. Bickers, whose father was chair of “the finest educational institution in the Middle East.” The late Calvin ob/gyn at AUB, is now trustee emeritus. Jacques P. Merab, a cardiol- H. Plimpton, MD, who received his MSD degree from P&S in 1951 and ogy faculty member at P&S, grew up in Beirut and has been an active was a longtime member of the faculty in the Department of Medicine at AUB trustee for several years. Thomas Jacobs, a faculty member in P&S, served for a time as professor and chairman of the Department of endocrinology at P&S, served as a trustee for several years. The AUB- Medicine and associate dean of the Faculty of Medical Sciences at AUB Columbia link has come full circle with the presidency of P&S alumnus and chief of staff of the American University Hospital before becoming Fadlo Khuri’89, whose father, Dr. Raja Najib Khuri, a former dean of the president. Thomas Q. Morris’58, former president and CEO of Presby- Faculty of Medicine and acting president of AUB, trained, served under, terian Hospital and current chairman of the editorial board of Columbia and became a close friend of Dr. Plimpton.

faculty and to which he remains devoted. “No In his inaugural remarks upon taking on the and science in Palestinian refugee camps and in margin, no mission!” was the mantra preached mantle of the presidency, Dr. Khuri boldly pro- the southern district of Beirut. by the trustee. Budgetary constraint was the posed, “Can we at AUB become the first brick About to lead a major capital campaign, Dr. common reason given for trimming the curricu- in a new Marshall Plan for the Arab world, a Khuri hopes to foster a meaningful sense of phi- lum. “You’ve got it a hundred percent wrong,” homegrown one?” Piloted by U.S. Secretary of lanthropy in Lebanon and the Middle East. “We Dr. Khuri responded. “It’s the mission that cre- State George Marshall following World War II need to substantially increase our endowment to ates the margin! If you’re no good at your edu- to bolster the shattered economy of Europe, spend on building our infrastructure and, most cational mission and you don’t believe in it, the including that of a defeated Germany, the importantly, on supporting our faculty and stu- margin’s going to go away, because some other Marshall Plan included a vigorous educational dents. But I want our prospective donors to give institution that does believe in their mission is component. Education should be a priority of because they truly believe in the cause. If they going to do a better job and achieve a better mar- support in the Middle East, Dr. Khuri argues, don’t believe in it, we don’t need their money.” gin, and they’re going to make you a dinosaur!” “not because of noblesse oblige, but because it’s When not promoting the cause of AUB, Dr. to everyone’s long-term strategic advantage.” Khuri flies to Atlanta, where his wife is still hold- A New Marshall Plan for the Arab World To address the rising cost of tuition, Dr. ing down the fort while their youngest finishes Energized by “a very creative and participatory Khuri has proposed, among other initiatives, a high school. For leisure activities, he follows faculty and staff, echoing the call of students national service and teaching model, whereby sports, in particular the exploits of the Boston who come in wanting to make a difference,” he in exchange for debt-forgiveness funded by the Red Sox, and takes long walks in the hills around argues that “a university can only do so much. Lebanese government, students pledge to teach Beirut. “Lebanon is a beautiful country. I’m very We can come up with the ideas, but society has in rural areas for a set number of years. As a comfortable with the people I meet, from whom to meet us halfway.” young man, Dr. Khuri taught English, math, I learn a lot. I’m still a perpetual student.”

www.columbiamedicinemagazine.org 35 in memoriam

Henry S. “Harry” Lodge Lewis P. “Bud” Rowland

FACULTY oversaw the Columbia neuromuscular diseases and of Medicine, formerly called and professor emeritus of Felix E. Demartini, MD, Public Voices Fellowship age-related neurodegenera- the Institute of Medicine. clinical medicine at P&S, professor emeritus of clini- Program, Dr. Lodge sought tive diseases, especially ALS, Dr. Rowland received bach- died Nov. 7, 2016. Under cal medicine and president to inspire Columbia faculty Dr. Rowland wrote many elor’s and medical degrees his leadership, the hospital and CEO of Presbyterian to participate in public dis- papers and edited two books from Yale University. began an expansion, includ- Hospital for nearly a course on medicine, health, on ALS. He was editor-in- ing the construction of the decade, died Nov. 7, 2016. and well-being. See more chief of the journal Neurol- Other Faculty Deaths Allen Pavilion and Milstein A graduate of Columbia in Alumni In Memoriam, ogy from 1977 to 1987 and Anne Bernstein, MD, clini- Hospital Building. He pre- College and P&S, he spent Class of 1985. had been a member of the cal professor of psychiatry, viously served as vice chair his entire career at Colum- editorial boards of the New died Oct. 31, 2016. See of the Board of Trustees bia. He served as hospital Lewis P. “Bud” Rowland, England Journal of Medicine more in Alumni In Memo- of Presbyterian Hospital, president from 1977 until MD, chair of neurology at and the Journal of Neuro- riam, Class of 1970 PSY. in which capacity he was the mid-1980s, overseeing P&S and director of the logical Sciences. He was the responsible for all scientific a modernization program Neurological Institute of editor of Merritt’s “Text- Nas S. Eftekhar, MD, pro- and health programs and that included the construc- New York for 25 years book of Neurology,” “Cur- fessor emeritus of clinical professional staffing at the tion of the Allen Pavilion and a leader in American rent Neurologic Drugs,” orthopedic surgery, died hospital. Dr. Demartini was (now Allen Hospital) and neurology, died March 16, and “Clinical Cases in Neu- Nov. 14, 2016. a former governor of the the Milstein Hospital 2017. When Dr. Rowland rology.” He also authored Downstate Areas for the Building. See more in the was recruited to P&S in “The Legacy of Tracy J. Michael C. Pitter, MD, American College of Physi- alumni In Memoriam, 1973 to chair neurol- Putnam and H. Houston assistant professor of cians. He served in the U.S. Class of 1946. ogy, it was a return to Merritt: Modern Neurol- obstetrics & gynecology, Army Medical Corps. Dr. the medical center where ogy in the United States” died Dec. 24, 2016. Demartini pursued some Henry S. “Harry” Lodge, he trained in neurology and wrote the history of of the first studies on the MD, the Robert L. Burch before joining the faculty. the National Institute for Laura Ponticorvo, PhD, effects of diuretics on the Family Professor of Medi- He rose through the ranks Neurological Disorders and research associate in excretion of uric acid. A cine and chair and CEO to become a full professor Stroke, even though he was biochemistry and obstetrics onetime star athlete, he of New York Physicians, before being recruited to fired from the NINDS dur- & gynecology, died was captain of the football LLP, died March 10, 2017. the University of Pennsyl- ing the McCarthy era for Dec. 8, 2016. team as an undergraduate He spent his entire medical vania in 1967 to chair neu- his work with the Ameri- at Columbia College. Retir- career at Columbia, joining rology for six years before can Association of Interns Eleanor Shelly, retired ing to Vero Beach, Fla., the faculty of P&S and the returning to Columbia. and Medical Students and instructor in occupational he served for a number hospital staff after complet- At Columbia, he founded his advocacy for national therapy and former director of years on the board of ing an internal medicine and co-directed the Eleanor health insurance. of occupational therapy ser- directors of the Indian internship and residency and Lou Gehrig MDA/ Dr. Rowland was past vices at Presbyterian Hospi- River Memorial Hospital. at Columbia-Presbyterian. ALS Center until 1999 and president of the American tal, died Feb. 16, 2016. Among his extra-medical With a patient, Dr. Lodge founded and co-directed Neurological Association, activities, he was an avid wrote the popular best-sell- the H. Houston Merritt the American Academy of ALUMNI golfer and served as presi- ing “Younger Next Year” Clinical Research Center for Neurology, and the Parkin- 1946 dent of Hawk’s Nest Golf book series. As director of Muscular Dystrophy and son’s Disease Foundation. Felix E. Demartini, for- Club in Vero Beach. Pre- the Health Sciences Com- Related Diseases at Colum- He was elected to the pres- mer president and CEO ceded in death by his wife, munication Project, which bia. Known for research in tigious National Academy of Presbyterian Hospital Mildred, he is survived by a

36 ColumbiaMedicine Spring/Summer 2017 Felix E. Demartini’46 Melvin Grumbach’48 Norman Bank’53 Stanley Edelman’53

daughter, two sons, includ- weighing in on the emo- Medical Education. Preceded anions, post-obstructive Society of Nephrology, ing Paul Demartini'77, tionally charged issue of in death by his wife, Mad- diuresis, glomerular hyper- in 1977 Dr. Bank was nine grandchildren, and gender identity, rejecting eleine Francis Grumbach’51, filtration in diabetes, renal honored with the Distin- 11 great-grandchildren. the then commonly held he is survived by two sons salt and water retention in guished Service Award of view that anatomy alone and five grandchildren. chronic bile duct obstruc- the National Kidney Foun- 1948 should dictate assigned gen- tion, parathyroid hormone dation. He subsequently Melvin Grumbach, a legend der to children born with 1953 modulation of proximal received the service award in pediatric endocrinology, ambiguous genitalia and Norman Bank, profes- tubular phosphate and from the American Society died of a heart attack on promoting a more complex sor emeritus of medicine bicarbonate transport and of Nephrology. Follow- Oct. 4, 2016, at age 90. Dr. appreciation of gender iden- (nephrology) at the Albert potassium transport by the ing his retirement and Grumbach, the Edward B. tity and a deeper engage- Einstein College of Medi- remnant kidney. Dr. James appointment as professor Shaw Distinguished Profes- ment with patients and cine and one of the found- Scheuer, former chief of the of medicine emeritus at sor of Pediatrics Emeritus their parents in the often ing fathers of nephrology, Department of Medicine Einstein, he continued to and former chair of the delicate decision-making died Sept. 17, 2016. at Montefiore, recalled be active, shepherding the Department of Pediatrics at process. His last published Author of more than 100 Dr. Bank as “a wonder- development of a computer the University of California paper, co-authored when peer-reviewed articles, Dr. ful model of how a smart, research database for the San Francisco, was credited he was 86, “Advice on the Bank was best known for successful leader should Kidney and Urologic Foun- with bringing international Management of Ambigu- his studies of sickle cell operate.” Of Dr. Bank’s dation of America. He also acclaim to pediatrics at ous Genitalia to a Young anemia and kidney func- research he wrote: “Many wrote several children’s UCSF. Author of close to Endocrinologist from tion. He served in the U.S. of us conducted research books, including “Evil 400 scientific papers, he Experienced Clinicians,” Army Air Force. Following and were ‘productive.’ Spirits at Camp AgoNee” was best known for his appeared in the journal a stint on staff at the New Looking back, very few of and “Arnold the Fearless,” landmark research on the Seminars in Reproduc- England Medical Center, us made important original and remained an active biological mechanisms tive Medicine. He served where he and his col- contributions. Norm did!” member of a writing group of sexual differentiation, as a captain in the U.S. leagues were credited with In the words of another sponsored by the Scarsdale growth, and puberty. Early Air Force Medical Corps. contributing to the birth longtime colleague at Ein- Library. He is survived on in his career, applying A past president of the of the medical specialty of stein, Dr. Joel Neugarten, by his wife, Ronee I. Her- insights from the then new American Pediatric Society nephrology, he was named “Norman Bank truly ranks rmann’54, a daughter, and field of cytogenetics and and the Endocrine Society, professor of medicine at among the pioneers and a son, David Bank’95. His working as a junior mem- Dr. Grumbach received Albert Einstein, where patriarchs of the field of family contributed to the ber of the faculty in the many honors, including the he served for more than nephrology. Norman mas- creation of a scholarship Department of Pediatrics UCSF Medal (that school’s two decades as chief of tered the [then] recently fund in the Bank family at P&S in the 1960s, he highest honor), the Koch the nephrology division developed technique of name at P&S. and a collaborator studied Award, the Borden Award at Montefiore Medical kidney micropuncture the hormonal regulation for Research of the Ameri- Center. His laboratory at and employed these newly Stanley Edelman, a retired of growth from the fetus can Academy of Pediatrics, Montefiore was credited acquired skills to make surgeon, athlete, and phi- through puberty. His lab the John Howland Medal with major contributions seminal contributions to lanthropist, died Dec. 30, was the first to reveal the of the American Pediatric in the area of mechanisms our rapidly expanding 2016. He was a longtime biomedical subtleties of Society, and the American of proximal tubule, acidi- understanding of how the member of the faculty in hypothalamic control. He Academy of Pediatrics Life- fication, K+ secretion due kidney works.” A past the Department of Surgery did not shy away from time Achievement Award in to non-reabsorbed distal president of the New York at Mount Sinai School of

www.columbiamedicinemagazine.org 37 in memoriam

David H. Barnhouse’54

Medicine, where he taught byterian Church in India, French Legion of Honor. engineering was established Johnson Medical School, Dr. house staff. As chair of the where he taught surgery A longtime member of in his name by the Alliance Reisfield pursued a private board of directors of the at the Christian Medi- the cardiac clinic at St. for Engineering in Medicine ob/gyn practice for many Henry Nias Foundation, cal College in Ludhiana, Luke’s-Roosevelt Hospital and Biology, of which he years in New Brunswick, he oversaw its support of Punjab. Returning to the Center, Dr. Keating was was a past president. Sur- N.J., delivering more than cultural and educational United States, he trained co-founder of the coronary vivors include his wife, Dr. 10,000 babies. He was programs in New York, and switched specialties to care unit at Good Samari- Joan Mayer, four daughters affiliated with Robert Wood including significant sup- urology, pursuing a private tan Hospital in Suffern, (three of them doctors), and Johnson University Hospital port for student financial practice in Pittsburgh, Pa. N.Y., where he earned the five grandchildren. and St. Peter’s Hospital. In aid at P&S and Mount After retiring from medi- Sister Joseph Rita Award his free time he pursued vari- Sinai and a professorship cal practice in 1993 he for Medical Excellence. James W. Rathe, a retired ous sports, and as a member in his name at both institu- became an ordained Epis- Preceded in death by his internist, died Nov. 12, of the Napoleonic Society tions. He was an active and copalian priest assisting at wife, Patricia, and a son, 2016. He served in the of America published loyal alumnus, serving as the Church of the Ascen- he is survived by two Army Corps of Engineers, papers on the impact of chair of his class for many sion in Pittsburgh. His daughters, four sons, and stationed in Heidelberg, medical issues on Napoleon years. In his free time other interests included 14 grandchildren. Germany. Dr. Rathe pur- Bonaparte. Survivors include Dr. Edelman trained for travel, choral music, sued a private practice his wife, Gray, a daughter, and ran in more than 35 opera, and jigsaw puzzles. Paul Mayer, a retired ortho- in internal medicine in three sons, eight grandchil- New York marathons, stay- Survivors include his wife, pedic surgeon, died Nov. 7, Waverly, Iowa, and main- dren, and a great-grandchild. ing fit by running against Mary, three children, and 2016. He served in the U.S. tained an affiliation with athletes many years his four grandchildren. Air Force during World Rohlf Memorial Clinic. He 1956 junior. A World War II War II. Clinical professor was a board member and Burton J. Lee III, a retired veteran, Dr. Edelman saw Paul Keating, a retired of orthopedic surgery and past president of the Iowa oncologist and former chief combat in the Battle of the cardiologist, died Sept. 18, adjunct professor of bio- Heart Association. Pre- of the medical unit at the Bulge, surviving the down- 2016. He served during medical engineering at the ceded in death by his wife, White House and personal ing of his plane behind World War II in the 2nd University of Miami School Evelyn, he is survived by physician to President enemy lines. His service was Battalion, 274th Regiment of Medicine, he pursued a a daughter, two sons, four George H.W. Bush, died recognized by the French of the 76th Division of private orthopedic practice grandchildren, and one Nov. 25, 2016. He was Legion of Honor Medal. the U.S. Army, a regiment in Miami, where he was a great-grandchild. 86. Dr. Lee volunteered He is survived by his wife, that was awarded a Presi- past president of the Miami for the Marine Corps and Ginny, a son, two daugh- dential Unit Citation for Orthopedic Society. Dr. Donald R. Reisfield, a subsequently served in the ters, four grandchildren, outstanding performance Mayer also served as chair- retired obstetrician/gyne- U.S. Army Medical Corps, and one great-grandchild. in combat for surviving man of the board of Victoria cologist, died Nov. 6, 2016, stationed in Stuttgart, bitter cold and dearth Hospital, as a member of at age 90. He served in the Germany. From 1989 to 1954 of food and water and the board of directors and armed forces during World 1993, he served as White David H. Barnhouse, a destroying two German SS chief of orthopedic surgery War II, saw combat in the House physician. He had retired urologist, died battalions while liberating of the Miami Heart Insti- Pacific, and was stationed previously served for more Oct. 1, 2016. He was 87. 250 American prisoners of tute, and as chief of ortho- in occupied Japan, where he than three decades as an Dr. Barnhouse served for war in Wingen, France. Dr. pedics at Cedars of Lebanon learned to speak Japanese. oncologist on the staff of some years as a medical Keating earned a Bronze Hospital. A scholarship for A clinical member of the Memorial Sloan Kettering missionary with the Pres- Star and a Chevalier of the excellence in biomedical faculty of Robert Wood Cancer Center, where he

38 ColumbiaMedicine Spring/Summer 2017 Paul Keating’54 Donald R. Reisfield’54 Burton J. Lee III’56 Sheila Horn Bisaillon’60 Keith Brodie’65

ran the lymphoma section weakness, not strength. the board of directors of universities. He launched they had the capacity to and developed treatment It is a reaction of govern- the Tarrytown Ambulance new interdisciplinary aca- go. But, of course, they’re protocols for Hodgkin’s ment officials overwhelmed Service. He is survived by demic initiatives, including a very happy when they disease and multiple by fear who succumb to his wife, Mary Elise, two School of the Environment, get there.” He previously myeloma that have since conduct unworthy of them daughters, and a son. the Levine Science Research taught in the Department become standard. He was and of the citizens of the Center, and the Sanford of Psychiatry at Stanford the principal or contribut- United States.” Dr. Lee 1960 Institute for Public Policy. University. Co-author of ing author on 141 research was descended from a long Sheila Horn Bisaillon, a He also helped push faculty more than 70 scientific papers. Retiring to Florida, family line of P&S gradu- biochemist and administra- diversity with a black fac- papers, co-author of a he remained active in medi- ates, including his paternal tor, died Nov. 18, 2016. Dr. ulty initiative and a program book, “Modern Clinical cine, serving first as volun- grandfather, Burton J. Bisaillon, a native of Mon- for preparing minorities Psychiatry,” and co-editor teer physician at, and later Lee Sr.’1898, a pioneer treal, Canada, was a mem- for academic careers and of “Controversy in Psychi- member of the board of, in cancer care; an uncle, ber of the family medicine promoted increased faculty atry,” “Critical Problems the Whole Family Health Hugh Auchincloss Sr.’1905, faculty at McGill University participation in governance. in Psychiatry,” “Signs and Center in Vero Beach. He founder of the breast and and medical director of Among other notable Symptoms in Psychiatry,” was commissioner of pub- hand surgical services at Queen Elizabeth Hospital accomplishments, he and “American Handbook lic health for Indian River Presbyterian Hospital; a of Montreal Centre, an doubled Duke’s endowment, of Psychiatry,” his research County for many years and cousin, Hugh Auchincloss affiliate of McGill. She sub- substantially increased focused on biochemical was instrumental in found- Jr.’42, a well-known breast sequently served as medical the level of corporate giv- substrates of mood disor- ing Alcohope, a nonprofit surgeon; and another judge in a Quebec provin- ing, and helped boost the ders. Upon his retirement, alcohol treatment recovery cousin, Elizabeth Auchin- cial Appeal Court in Health undergraduate and graduate he authored yet another center in Vero Beach. In closs’76. A loyal alumnus, Law. Preceded in death by applicant pool. Dr. Brodie book, “The Research Uni- 2005, in the wake of news Dr. Lee was a generous two former husbands and a came to Duke as a professor versity Presidency in the reports of prisoner abuse by supporter of his medical son, she is survived by two and chair of the Department Late 20th Century,” based U.S. military at Abu Ghraib alma mater, to which he sons, a daughter, a stepson, of Psychiatry and director of on interviews conducted Prison in Iraq and at Guan- remained eternally devoted. and nine grandchildren. psychiatric services at Duke with former and current tanamo Bay detention camp Survivors include his wife, University Medical Center. academic leaders. A star in in Cuba, Dr. Lee took a Anne, two daughters, a son, 1965 He was subsequently named psychiatry, he had been the bold stand, publishing an three stepdaughters, and Keith Brodie, a distin- James P. Duke Professor of youngest president of the op-ed piece in the Washing- five grandchildren. guished psychiatrist, former Psychiatry and served as American Psychiatric Asso- ton Post officially opposing president of Duke Univer- chancellor for three years ciation. He also was chair- torture and abuse in the 1957 sity, and past president of before taking the reins as man of the board of mental interrogation of prisoners Raymond D. Mutter, a the American Psychiatric president. A leader, accord- health and behavioral by U.S. forces, a practice retired internist, died Nov. Association, died Dec. 2, ing to Dr. Brodie, who medicine at the Institute that had been tolerated and 29, 2016. He served in the 2016. He was 77. During summed up his philosophy of Medicine, now called even sanctioned during the U.S. Army, stationed in his tenure at the helm of in an alumni profile in the National Academy administration of George Germany. Dr. Mutter was Duke, Dr. Brodie helped Columbia Medicine, “is of Medicine. He was the W. Bush. He responded in affiliated for many years raise the school’s profile someone who takes people recipient of two honorary no uncertain terms: “Amer- with Phelps Memorial Hos- from that of a respected where they might not have degrees and many other ica cannot continue down pital in Tarrytown, N.Y., regional contender to one thought they wanted to go encomia, including the Dis- this road. It demonstrates and served as a member of of the nation’s top research or might not have thought tinguished Alumni Award

www.columbiamedicinemagazine.org 39 in memoriam

Mark E. Josephson’69 Anne E. Bernstein’70 PSY Harvey W. Topilow’75

from P&S and the William Thorndike Electrophysiol- Dr. Josephson was par- American Association for and gatherers by nature and C. Menninger Memorial ogy Institute and Arrhyth- ticularly proud of having Accreditation of Ambula- so did their best when in Award from the Institute of mia Services at Beth Israel/ helped train and mentor tory Surgery Facilities. He motion. The message spoke Pennsylvania Hospital. The Deaconess Medical Center more than 250 cardiac launched the Foundation to aging Baby Boomers, and Keith and Brenda Brodie in Boston, died Jan. 11, electrophysiology fellows for Surgical Reconstruction, the book, a wake-up call to Recreation Center at Duke 2017. Considered one of in the course of his career. committed to raising funds exercise and healthy eating, was named for him and his the “fathers” of the field Preceded in death by his to cover reconstructive sur- sold millions. The book wife, Brenda, a 1965 gradu- of electrophysiology, he wife, Joan, he is survived gery for uninsured patients also inspired a PBS special ate of the Columbia School attained international by two daughters and three or those denied coverage. “Younger Next Year: The of Nursing, who survives prominence for designing grandchildren. New Science of Aging,” in him. He is also survived by new procedures that make 1975 which Dr. Lodge expounded a daughter, three sons, and possible the selection of 1970 PSY Harvey W. Topilow, a retina on the biological impact of four grandchildren. appropriate drugs for treat- Anne E. Bernstein, a vitreous surgeon in private motion and emotion on the ment of potentially lethal member of the clinical psy- practice, died Jan. 6, 2017. body and the brain. Robert 1966 arrhythmias and for devel- chiatry faculty at P&S and Dr. Topilow was a member Burch Family Professor David C. Lowance, a retired oping surgical procedures Weill Cornell Medical Col- of the clinical faculty in oph- of Medicine at P&S, Dr. nephrologist, died Sept. 9, to address arrhythmias lege, died Oct. 31, 2016, at thalmology at Albert Ein- Lodge was chair and chief 2016, from complications not treatable by drugs. He age 79. In addition to her stein College of Medicine. executive of New York of Parkinson’s disease. He was the author of more private practice and teach- He is survived by his wife, Physicians, a multispecialty joined his father in an inter- than 450 peer-reviewed ing, she was active with the Lorena, and two daughters. medical practice, and also nal medicine practice at the articles and the widely American Medical Wom- contributed health-related Lowance Clinic in Atlanta, respected book, “Clinical en’s Association, mentoring 1979 articles to Self magazine. He Ga., where he was also affil- Cardiac Electrophysiology and promoting the careers Celia Beth Blumenthal, a came from a distinguished iated with Piedmont Hospi- Techniques and Inter- of women in medicine. She child psychiatrist and acu- Massachusetts family. His tal. Dr. Lowance helped to pretations.” He received is survived by her husband, puncturist, died May 25, grandfather, Henry Cabot establish a kidney transplant many honors, including Richard K. Bernstein, MD, 2016, after a long battle Lodge Jr., was a Massa- program in Atlanta and the Distinguished Teacher four daughters, two sons, with ovarian cancer. Dr. Blu- chusetts senator and later joined Lifelink of Georgia, a Award from the North and four grandchildren. menthal was an attending at ambassador to the United not-for-profit organization American Society for Pac- Mount Sinai Hospital. She is Nations. Dr. Lodge is sur- devoted to the recovery of ing and Electrophysiology, 1972 survived by three children. vived by two daughters organs and tissue for trans- a Columbia University Michael F. McGuire, for- and his companion, Laura plantation therapy. Survi- Medal of Excellence, the mer chief of plastic sur- 1985 Yorke. A loyal P&S alum- vors include his wife, Lynn, Paul Dudley White Award gery at St. John’s Health Henry S. Lodge, an inter- nus, Dr. Lodge supported two daughters, a son, and from the American Heart Center in Santa Monica, nist specializing in geriatric the endowment of a schol- three stepchildren. Association, and the 2017 Calif., died Nov. 14, 2016. medicine and author of a arship fund in his name. Distinguished Scientist He was a member of the best-selling book series, 1969 Award (Basic Domain) of clinical faculty in surgery “Younger Next Year,” OTHER ALUMNI Mark E. Josephson, the American College of at UCLA. Dr. McGuire died March 10, 2017, of DEATHS professor of medicine at Cardiology. He served as was a past president of prostate cancer. He was 58. Lawrence Crane’42 Harvard and founding a military medical officer the California Society of According to Dr. Lodge, Robert Comly Wilson III’44 director of the Howard during the Vietnam War. Plastic Surgeons and the humans remained hunters Frank Rees Smith’62

40 ColumbiaMedicine Spring/Summer 2017

630 West 168th Street Non-Profit Org. New York, NY 10032 U.S. Postage Paid New York, NY PERMIT NO. 3593

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Giving Back “Almost immediately after arriving at P&S in the summer of 1984 I realized I was someplace quite unique. Born the grandson of Spanish and Cuban immigrants, I was able to communicate in Spanish with the Dominican employees where I got coffee most mornings. The difficult circumstances of their lives were not lost on me, and, grateful for the opportunity with which I had been presented, I vowed that one day I would give back. For ‘‘nearly a decade and a half I have been doing just that—not’’ in ‘‘’’‘‘ Washington Heights but in sub-Saharan Africa, where I share my skills as a urologist with surgeons from Senegal to Ethiopia. I teach in their sparsely outfitted operating rooms and provide them material support. In the outskirts of Dakar, in the village of Yeumbeul, live nearly 300,000 people without access to basic medical care. With the help of my Senegalese colleagues I am building a clinic there that will house a dentist, a nurse midwife, an internist, a pharmacy, and a laboratory. Physician residences on the building’s third floor will allow medical volunteers to live comfortably while exploring both the difficulties and great rewards of providing health care to one of the world’s most underserved populations. My ties to P&S remain strong. I have been back on its campus to share some of the highlights of my African project. My dream is to have the clinic in Senegal supported by fellow alumni who, in return for the opportunity they have been given, also feel the need to give something back.” — Al Ruenes’88

This was adapted from the Scrapbook section of the P&S 250 website, 250.ps.columbia.edu, where the P&S community is invited to submit reflections and stories about the medical school.