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A Science State of Mind NEW YORK: A SCIENCE STATE OF MIND Biophysicist Mark Kaplan Nutrition Science: Pushing the Frontiers of Fast-Tracks Patient Innovations Important for Policy Molecular Medicine Decisions? www.nyas.org • Spring 2014 Board of Governors Chair Vice Chair Treasurer NANCY ZIMPHER PAUL WALKER ROBERT CATELL President [ex officio] Secretary [ex officio] Spring 2014 ELLIS RUBINSTEIN LARRY SMITH Governors LEN BLAVATNIK ELAINE FUCHS MEHMOOD KHAN FRANK WILCZEK MARY BRABECK ALICE P. GAST JEFFREY D. SACHS DEREK YACH NANCY CANTOR BRIAN GREENE KATHE A. SACKLER MICHAEL ZIGMAN MARTIN CHALFIE THOMAS L. HARRISON MORTIMER D.A. SACKLER MILTON COFIELD THOMAS C. JACKSON GEORGE E. THIBAULT KENNETH L. DAVIS BETH JACOBS PAUL WALKER MIKAEL DOLSTEN JOHN E. KELLY III IRIS WEINSHALL International Governors Chairman Emeriti Honorary Life Governors SETH F. BERKLEY TONI HOOVER JOHN E. SEXTON KAREN E. BURKE MANUEL CAMACHO SOLIS RAJENDRA K. PACHAURI TORSTEN N. WIESEL HERBERT J. KAYDEN GERALD CHAN RUSSELL READ JOHN F. NIBLACK S. KRIS GOPALAKRISHNAN PAUL STOFFELS President’s Council PETER AGRE AARON CIECHANOVER GREGORY LUCIER ELLIOTT SIGAL Nobel Laureate & Univ. Nobel Laureate & Former Chairman and CEO, CSO, Bristol-Myers Squibb Prof. and Director, Johns Distinguished Research Prof., Life Technologies Corp MICHAEL SOHLMAN Hopkins Malaria Research Tumor and Vascular Biology RODERICK MACKINNON Former Exec. Director, The Inst., Dept. Molecular Research Center, Faculty of Nobel Laureate & John Nobel Foundation On the cover: Microbiology and Medicine, Technion-Israel D. Rockefeller, Jr. Prof., PAUL STOFFELS Samuel Stuart Photography Immunology, Bloomberg Inst. of Tech., Haifa, Israel The Rockefeller Univ.; CSO, Johnson & Johnson; School of Public Health PETER DOHERTY Investigator, HHMI Worldwide Co-Chairman, contents RICHARD AXEL Nobel Laureate & GERALD J. MCDOUGALL Pharmaceuticals Group Nobel Laureate & Researcher, St. Jude National Partner, Global MARC TESSIER-LAVIGNE Professor, Columbia Univ.; Children’s Research Pharmaceutical & Health President, The Rockefeller Univ. Investigator, HHMI Hospital, Memphis, TN; Sciences Practice, MARY ANN TIGHE DAVID BALTIMORE Univ. of Melbourne PricewaterhouseCoopers CEO, New York Tri-State Columns Op-Ed Nobel Laureate & President MIKAEL DOLSTEN LLP Region, CB Richard Ellis Emeritus, Caltech President, Worldwide RICHARD MENSCHEL SHIRLEY TILGHMAN Why Science? Why Now? ETIENNE-EMILE BAULIEU Research and Development; Sr. Director, Goldman Sachs President Emerita and 2 Letter from the President 7 A reporter’s question sparks a reflection on whether nutrition science has a Former President, French Sr. VP, Pfizer Inc RONAY MENSCHEL Prof. of Molecular Biology, New York Scientific Leadership: Academy of Sciences MARCELO EBRARD Chairman of the Board, Princeton Univ. role in policy discussions and decisions. PAUL BERG CASAUBÓN Phipps Houses; Board of XAVIER TRIAS Executive Editor From Dream to Reality Nobel Laureate & Prof. Mayor, Mexico City Overseers, Weill Cornell Mayor of Barcelona Diana Friedman Emeritus, Dept. of EDMOND H. FISCHER Medical College FRANK WALSH Cover Story Biochemistry, Stanford Univ. Nobel Laureate & Prof. HEATHER CEO, Ossianix, Inc. 4 Inside the Academy LEN BLAVATNIK Emeritus, Dept. of MUNROE-BLOOM GERALD WEISSMANN Art Director Chairman, Access Industries Biochemistry, Univ. of Former Principal and Vice- Prof. of Medicine, NYU News about Academy programs 12 New York: A Science State of Mind GÜNTER BLOBEL Washington Chancellor, McGill Univ. School of Medicine Ash Ayman Shairzay and activities An introduction to New York’s newest role: that of an undisputed scientific Nobel Laureate & Director, JEROME I. FRIEDMAN FERID MURAD JOHN WHITEHEAD Laboratory for Cell Biology, Nobel Laureate & Institute Nobel Laureate & Director, Former Chairman, Lower powerhouse. The Rockefeller Univ. Prof. & Prof. of Physics, IMM Center for Cell Manhattan Development Contributors 8 Academy eBriefings IRINA BOKOVA Emeritus, MIT Signaling, The University of Corp.; former Co-Chairman Director General, United JOSEPH GOLDSTEIN Texas at Houston of Goldman Sachs David Alvaro, Mandana Arabi, Summaries of recent eBriefings Member Memoir Nations Educational, Nobel Laureate & Chairman, JOHN F. NIBLACK GEORGE WHITESIDES Sharon Begley, Azra Jaferi, Scientific and Cultural Molecular Genetics, Univ. Former President, Pfizer Woodford L. & Ann A. A New Model for Industry Hannah Rice 22 Annals Highlights 18 Organization (UNESCO) of Texas Southwestern Global Research & Flowers Univ. Prof., Harvard Biophysicist Mark Kaplan explores a fast-track to bring innovation to SYDNEY BRENNER Medical Center Development Univ. Recent and upcoming Annals Nobel Laureate & S. GOPALAKRISHNAN PAUL NURSE TORSTEN N. WIESEL patients. Distinguished Prof., Salk Inst. Exec. Co-Chairman of the Nobel Laureate & President, Nobel Laureate & former Editorial Office volumes MICHAEL S. BROWN Board, Infosys Technologies The Royal Society; former Secy. General, Human 7 World Trade Center Nobel Laureate & Prof. of Limited President, The Rockefeller Frontier Science Program Academy Interview Molecular Genetics, Univ. PAUL GREENGARD Univ. Organization; President 250 Greenwich St, 40th Fl 25 Member News of Texas Southwestern Nobel Laureate & Prof. RICHARD ROBERTS Emeritus, The Rockefeller New York, NY 10007-2157 Awards, appointments, and 20 Medical Center of Molecular & Cellular Nobel Laureate & CSO, Univ. Changing the Face of Molecular LINDA BUCK Neuroscience, The New England Biolabs FRANK WILCZEK Phone: 212.298.8645 announcements about Academy Medicine Nobel Laureate & Rockefeller Univ. EDWARD F. ROVER Nobel Laureate & Herman Fax: 212.298.3655 members Investigator for HHMI; GLENDA GREENWALD President, The Dana Feshbach Professor of John O’Shea turns his passion for clinical care into a successful research member of the Fred President, Aspen Brain Foundation Physics, MIT Email: [email protected] Hutchinson Cancer Forum Foundation F. SHERWOOD ROWLAND ERNST-LUDWIG Calendar career. Research Center PETER GRUSS Nobel Laureate & Prof. of WINNACKER 26 KAREN E. BURKE President, Max Planck Chemistry & Earth Science, Secy. General, Human Membership & Annals Orders Upcoming Academy conferences Last Look Dermatologist & Research Gesellschaft, Germany Univ. of California, Irvine Frontier Science Program; Phone: 212.298.8640 Scientist WILLIAM A. HASELTINE BENGT SAMUELSSON former Secy. General, and meetings 28 MARCELO EBRARD President, The Haseltine Nobel Laureate & Prof., European Research Council; Fax: 212.298.3650 The Academy’s impact by the CASAUBON Foundation for Medical Medical & Physiological former President, Deutsche Former Mayor, Mexico City Sciences and the Arts; Chem., Karolinska Inst.; Forschungsgemeinschaft, Email: [email protected] THOMAS R. CECH Chairman, Haseltine Global former Chairman, The Germany numbers. Nobel Laureate & Health, LLC Nobel Foundation ANDREW WITTY Distinguished Prof., Univ. of ERIC KANDEL IVAN SEIDENBERG CEO, GlaxoSmithKline Advertising Inquiries Colorado, Boulder Nobel Laureate & Prof., Advisory Partner, Perella DATO ZAKRI ABDUL HAMID Phone: 212.298.8636 MARTIN CHALFIE Physiology & Cell Biology, Weinberg Partners LP; former Science Advisor to the Nobel Laureate & Univ. Columbia Univ. Chairman of the Board, Verizon Prime Minister of Malaysia Email: [email protected] Prof., Dept. of Biological KIYOSHI KUROKAWA ISMAIL SERAGELDIN ELIAS ZERHOUNI Sciences, Columbia Univ. Former Science Advisor to Director, Bibliotheca President, Global CECILIA CHAN the Prime Minister of Japan; Alexandrina, The Library of Research & Development, Visit the Academy online Managing Director, Gold Prof., National Graduate Alexandria, Egypt Sanofi-Aventis www.nyas.org Avenue Ltd. Institute for Policy Studies PHILLIP A. SHARP AHMED ZEWAIL (GRIPS) Nobel Laureate & Director, Nobel Laureate & Linus LEON LEDERMAN McGovern Inst., MIT Center Pauling Chair of Chemistry Nobel Laureate & Pritzker for Cancer Research and Physics, Caltech Prof. of Science, Illinois GUANGZHAO ZHOU Inst. of Tech.; Resident Former Chairman, Chinese Scholar, Illinois Math & Association of Science & Science Academy Technology Letter from the President New York Scientific Leadership: From Dream to Reality hen he was a teenager grow- proached Kareem to remind him of their health and education, of poverty reduc- ing up in Brooklyn, his par- previous meeting—as two skinny kids on tion, of urban growth and sustainability. ents and teachers recognized the basketball court. Now here they were, A third factor: the most generous Wthat he had unusual talents in math and a winner of the Nobel Prize in Physiol- benefactors on the planet. We in New science. Lacking money, they sent him ogy and Medicine and a man known as York have always been blessed by this. to the renowned public magnet school, one of the greatest basketball players of all Edison and Bell saved the journal Science Stuyvesant, which, in those days, was just time, and it seemed safe to say, each had from bankruptcy. Andrew Carnegie gave east of 2nd Avenue on Stuyvesant Square. achieved his dreams. a million dollars to the five principal engi- Because he was tall and gangly, he made New York has always been a place for neering associations so they could come first-string center of the not-very-com- dreamers. It has been the embodiment of together in New York to create synergies petitive school basketball team. And that what the Dutch tried to inculcate in their that would make our city the world’s hub was his dream. As he plied the subway most international and democratic nation
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