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PEDIATRICS Volume 140, number 3, September 2017 1

Cohen et al https://doi.org/10.1542/peds.2017-1095 September 2017 High-Expenditure Pharmaceutical Use Among Children in Medicaid 3 140 Pediatrics 2017 ROUGH GALLEY PROOF SUPPLEMENTAL TABLE 3 Individual Medications With the Highest Estimated Expenditures Per Prescription (Top 50) Among Medications Used in Medicaid According to 2013 National Medicaid Use Data NDC Medication Class Generic Drug Name Estimated Expenditures Per Prescription ($) 169720501 Coagulation, anticoagulation factors Coagulation factor VIIa 118 450.62 169704001 Coagulation, anticoagulation factors Coagulation factor VIIa 103 495.48 169705001 Coagulation, anticoagulation factors Coagulation factor VIIa 85 549.53 76125066730 Coagulation, anticoagulation factors Antihemophilic factor VIII human 79 780.11 64193042502 Coagulation, anticoagulation factors Anti-inhibitor coagulant complex 77 022.54 64193022502 Coagulation, anticoagulation factors Anti-inhibitor coagulant complex 73 082.46 169720201 Coagulation, anticoagulation factors Coagulation factor VIIa 58 514.20 68516460402 Coagulation, anticoagulation factors AHF human, Von Willebrand factor 43 688.47 63004871001 Pituitary hormones Corticotropin, repository 42 089.22 26379770 Coagulation, anticoagulation factors Antihemophilic factor VIII (recombinant) 41 037.00 58394001603 Coagulation, anticoagulation factors Antihemophilic factor (recombinant) plasma, 40 817.74 albumin-free 944296510 Coagulation, anticoagulation factors Antihemophilic factor (recombinant) plasma, 40 412.41 albumin-free 944294810 Coagulation, anticoagulation factors Antihemophilic factor (recombinant) plasma, 39 682.05 albumin-free 53813502 Coagulation, anticoagulation factors AHF VIII (recombinant) sucrose formulated 39 549.06 66621101006 Miscellaneous therapeutic agents Nitisinone 39 524.68 169702001 Coagulation, anticoagulation factors Coagulation factor VIIa 39 434.34 63004773101 Pituitary hormones Corticotropin, repository 38 610.30 58394063703 Coagulation, anticoagulation factors Coagulation factor IX recombinant 38 163.24 52276031260 Electrolytic, caloric, water Carglumic acid 33 215.46 26379660 Coagulation, anticoagulation factors Antihemophilic factor VIII (recombinant) 32 455.93 49663000225 Miscellaneous therapeutic agents Cysteamine bitartrate 30 897.97 26378660 Coagulation, anticoagulation factors Antihemophilic factor VIII (recombinant) 30 478.99 64193022402 Coagulation, anticoagulation factors Anti-inhibitor coagulant complex 29 990.89 54092070202 Miscellaneous therapeutic agents Icatibant acetate 28 972.87 944284510 Coagulation, anticoagulation factors Antihemophilic factor VIII (recombinant) 28 898.42 944294610 Coagulation, anticoagulation factors Antihemophilic factor (recombinant) plasma, 28 703.17 albumin-free 58394001501 Coagulation, anticoagulation factors Antihemophilic factor (recombinant) plasma, 28 692.34 albumin-free 42227008105 Immunosuppressants C1 esterase inhibitor, human 27 679.77 944296410 Coagulation/anticoagulation factors Antihemophilic factor (recombinant) plasma, 26 730.88 albumin-free 67467018202 Coagulation, anticoagulation factors AHF human, Von Willebrand factor 26 107.72 64193042402 Coagulation, anticoagulation factors Anti-inhibitor coagulant complex 25 945.15 944294510 Coagulation, anticoagulation factors Antihemophilic factor (recombinant) plasma, 25 895.45 albumin-free 63833082502 Immunosuppressants C1 esterase inhibitor, human 25 328.08 58394063603 Coagulation, anticoagulation factors Coagulation factor IX recombinant 25 326.60 58394002503 Coagulation, anticoagulation factors Antihemophilic factor (recombinant) plasma, 25 303.33 albumin-free 51167020002 Respiratory tract agents Ivacaftor 25 152.45 53623302 Coagulation, anticoagulation factors Factor IX human, purified 24 575.80 63833061702 Coagulation, anticoagulation factors AHF human, Von Willebrand factor 24 470.18 53813402 Coagulation, anticoagulation factors AHF VIII (recombinant) sucrose formulated 24 467.58 169720101 Coagulation, anticoagulation factors Coagulation factor VIIa 24 388.35 944284410 Coagulation, anticoagulation factors Antihemophilic factor VIII (recombinant) 24 048.62 63833051802 Coagulation, anticoagulation factors Factor XIII human 23 908.39 68516460302 Coagulation, anticoagulation factors AHF human, Von Willebrand factor 23 889.57 66621100506 Miscellaneous therapeutic agents Nitisinone 22 916.95 944294410 Coagulation, anticoagulation factors Antihemophilic factor (recombinant) plasma, 22 022.81 albumin-free 66215020190 Miscellaneous therapeutic agents Miglustat 21 841.93 47783010101 Miscellaneous therapeutic agents Ecallantide 21 076.93

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Cohen et al https://doi.org/10.1542/peds.2017-1095 September 2017 High-Expenditure Pharmaceutical Use Among Children in Medicaid 3 140 Pediatrics 2017 ROUGH GALLEY PROOF