GENDER and UNIVERSITY SPINOUTS in the UK: Geography, Governance and Growth
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Pooled CRISPR-Activation Screening Coupled with Single-Cell RNA-Seq in Mouse Embryonic Stem Cells
ll OPEN ACCESS Protocol Pooled CRISPR-activation screening coupled with single-cell RNA-seq in mouse embryonic stem cells Celia Alda-Catalinas, Melanie A. Eckersley-Maslin, Wolf Reik celia.x.aldacatalinas@gsk. com (C.A.-C.) [email protected]. uk (W.R.) Highlights Protocol for CRISPRa screens with single- cell readout to interrogate gene function Detailed description of CRISPRa screening procedures in mouse embryonic stem cells Detailed steps on how to construct derived single-cell sgRNA amplicon libraries CRISPR/Cas9 screens are a powerful approach to identify key regulators of biological processes. By combining pooled CRISPR/Cas9 screening with a single-cell RNA-sequencing readout, individual perturbations can be assessed in parallel both comprehensively and at scale. Importantly, this allows gene function and regulation to be interrogated at a cellular level in an unbiased manner. Here, we present a protocol to perform pooled CRISPR-activation screens in mouse embryonic stem cells using 103 Genomics scRNA-seq as a readout. Alda-Catalinas et al., STAR Protocols 2, 100426 June 18, 2021 ª 2021 The Authors. https://doi.org/10.1016/ j.xpro.2021.100426 ll OPEN ACCESS Protocol Pooled CRISPR-activation screening coupled with single-cell RNA-seq in mouse embryonic stem cells Celia Alda-Catalinas,1,4,7,* Melanie A. Eckersley-Maslin,1,5,6 and Wolf Reik1,2,3,8,* 1Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK 2Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK 3Centre for Trophoblast Research, University of -
The Oxford – Cambridge Arc Home of the New Innovation Economy
Economic Vision: The Oxford – Cambridge Arc Home of the New Innovation Economy April 2019 Contents 1 Introduction 3 2 The Economic Vision 8 3 The New Innovation Economy: Sectors 11 4 The Innovation & Growth Network 24 5 Achieving Ambitions 29 6 Conclusion: Critical Mass 35 | Introduction 1 Introduction 1.1 This vision’s purpose The purpose of the Economic Vision is to explain the Oxford - Cambridge Arc’s unified proposition as a globally leading innovation and growth catalyst. The Arc offers access to each of the critical ingredients for business and innovation-led growth. This collective offer represents a powerful and coherent expression of the region’s current assets and future potential. This Economic Vision for the Arc sets out an ambition and series of proposals designed to unlock the economic potential of the region and deliver transformative growth for the UK between now and 2050. It provides a vision for how the Arc can better connect its unique and world-leading assets to become truly globally competitive in frontier markets, both for business investment and for top talent. With a bolder brand and stronger international presence the Arc can continue to lead the whole of the UK to the forefront of global innovation excellence in the coming years and decades. 3 | Introduction This Economic Vision is built upon the foundation of This Economic Vision has been developed in the four local industrial strategies which currently partnership with the three LEPs and the Combined demarcate the Arc’s geographic area. These have Authority, who have been given a mandate by Central been prepared by the Oxfordshire (OxLEP), South Government to drive forwards the Economic Vision for East Midlands (SEMLEP) and Buckinghamshire the Arc: Thames Valley (BTVLEP) Local Enterprise Partnerships, as well as the Cambridgeshire & Peterborough Mayoral Combined Authority (CPCA). -
Minutes of the Proceedings
MINUTES OF THE PROCEEDINGS at the Thirty‐sixth Meeting of the COUNCIL of the IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE The Thirty‐sixth Meeting of the Council was held in the Council Room, 170 Queen’s Gate, South Kensington Campus, Imperial College London, at 10:00 a.m. on Friday, 16th May 2014, when there were present: The Baroness Manningham‐Buller (Chair), Professor A. Anandalingam, Mr. C. Brinsmead, Dame Ruth Carnall, Mrs. P. Couttie, Professor M.J. Dallman, Mr. P. Dilley, Mr. D. Goldsmith, Professor N. Gooderham, Professor Dame Julia Higgins, Professor D.P.A. Kelleher, Ms. J.R. Lomax, Professor J. Magee, Mr. J. Newsum, Mr. S. Newton, Ms. K. Owen, Mr. M. Sanderson, Professor J Stirling, the President & Rector and the Clerk to the Court and Council. Apologies Mr. I. Conn. MINUTES Council – 7th February 2014 1. The Minutes of the thirty‐fifth Meeting of the Council, held on Friday, 7th February 2014, were taken as read, confirmed and signed. CHAIR’S REPORT 2. The Chair advised members that, following his appointment as Chair of the Chelsea and Westminster Hospital NHS Foundation Trust, Sir Thomas Hughes‐Hallett had resigned as a co‐opted member of the Council on 11 February. PRESIDENT & RECTOR’S REPORT 3. The President & Rector reported that this year’s Imperial Festival, held on 9th and 10th May, had received many visitors at the South Kensington campus to enjoy the various demonstrations, talks 1 Council 16th May 2014 and other activities on offer. What had started as a relatively modest pilot project in 2012 to explore how Imperial College London might share its research with more people had now evolved into a large‐scale and prominent annual fixture in the College’s calendar. -
Medical Research Council Annual Report and Accounts 2006/07 HC 93
06/07 Annual Report and Accounts © Crown Copyright 2006 The text in this document (excluding any Royal Arms and departmental logos) may be reproduced free of charge in any format or medium providing that it is reproduced accurately and not used in a misleading context. The material must be acknowledged as Crown copyright and the title of the document specified. Any queries relating to the copyright in this document should be addressed to The Licensing Division, HMSO, St Clements House, 2-16 Colegate, Norwich, NR3 1BQ. Fax: 01603 723000 or e-mail: licensing@cabinet-office.x.gsi.gov.uk 2 MRC Annual Report and Accounts 2006/07 Medical Research Council Annual Report and Accounts 2006/07 Presented to Parliament by the Secretary of State, and by the Comptroller and Auditor General in pursuance of Schedule I, Sections 2(2) and 3(3) of the Science and Technology Act 1965. Sir John Chisholm Chairman Professor Sir Leszek Borysiewicz Deputy Chairman and Chief Executive Ordered by and printed on London: The Stationery Office 6 February 2008 Price: £18.55 HC 93 The Medical Research Council The MRC RCUK The Medical Research Council (MRC) was set up in 1913 to administer Research Councils UK (RCUK) is a partnership of the seven (formerly public funds for medical research. It was incorporated under its eight) UK Research Councils – public bodies funded mainly by the UK present title by Royal Charter in 1920. A supplemental charter was Government via OSI. granted in 1993 describing the MRC’s new mission following the 1993 government white paper on science and technology. -
Michael John Owen Wakelam 1955–2020
obituary Michael John Owen Wakelam 1955–2020 We have lost a distinguished biochemist who dedicated his career to the study of phosphatidylinositol signalling in metabolic regulation and to the advancement of lipidomics. ichael John Owen Wakelam passed away on 31 March, 2020 at the Mage of 64, much too early. He became known to colleagues and friends as a scientist highly regarded for his research. He was honoured in 2018 with the Morton Lectureship of the Biochemical Society and was elected a fellow of the Royal Society of Biology. In 2019, he was elected a member of the Academia Europaea. Academic career It was not by chance that Michael turned his focus to phosphatidylinositols (PIs) and lipid signalling. He was a student and later a professor at the University of Birmingham at a time when Britain was the world’s hub of pioneering phospholipid research, such as that by J. N. Hawthorne and Bob Michell on PI in Birmingham. Bob Michell inspired Michael extraordinarily, and they even published a joint review. Subsequently, Michael moved to Cambridge to serve as the director of the Babraham Institute, where Credit: Babraham Institute Rex Dawson and Robin Irvine studied phospholipids, particularly PI metabolism and signalling. A joint publication by Michael and Irvine appeared as well. the Babraham Institute, and he received an the Keystone Symposia on Molecular and Certainly, Michael’s scientific engagement honorary professorship in lipid signalling at Cellular Biology. can be seen in the tradition of these eminent the University of Cambridge Clinical School. phospholipid scientists. In addition, he was an honorary professor Lipid signalling and metabolism Michael’s career path is impressive. -
West of England Strategic Economic Plan 2015-2030 01 Contents
WE ARE A PARTNERSHIP FOR GROWTH EMBRACING GROWTH DEAL NEGOTIATIONS FOR 2015-2021 WEST OF ENGLAND STRATEGIC ECONOMIC PLAN 2015-2030 01 CONTENTS Curriculum Vitae: Knowledge, Innovation, Quality of Life 03 Forewords by James Dyson and Colin Skellett 04 1 The West of England Strategic Economic Plan 06 2 The City Region of Choice for a sustainable future 18 3 Economic Strategy 24 4 Local Growth Fund Deal Negotiations 31 5 Using our Levers of Growth 62 5.1 People – Knowledge Economy, Skills & Social Inclusion 63 5.2 Place & Infrastructure 70 5.3 Investment & Promotion 78 5.4 SME Business Support 82 6 Implementation Plan 88 7 Delivery Plan 96 8 Evaluation Plan 106 Appendices 112 Appendix 1: Six Year Plan for the Local Growth Fund 114 Appendix 2: FE Capital Projects – a breakdown of individual proposals 116 Appendix 3: Deadweight and displacement calculations 118 Appendix 4: Pipeline of interventions for the Local Growth Fund 120 3-6 year programme Appendix 5: The Process to identify Interventions for the 124 Local Growth Fund Appendix 6: Shared Priority Investment Maps & Key 126 Appendix 7: Full Business Case Template 138 Technical Supporting Documents available on the LEP website: www.westofenglandlep.co.uk/strategicplan 1 Outline Business Cases for the Local Growth Fund current 2 year programme 2 LEP Sector Prospectus 3 Equality Impact Assessment CuRRICULUM VITAE: KNOWLEDGE, INNOVATION, QUALITY OF LIFE 02|03 CuRRICULUM VITAE KNOWLEDGE, INNOVATION, QUALITY OF LIFE • Over one million people and growing Knowledge Quality of Life • An economy worth -
Enterprising Universities Using the Research Base to Add Value to Business
Policy Report September 2010 Enterprising Universities Using the research base to add value to business 1100901_EnterprisingUniversities.indd00901_EnterprisingUniversities.indd A 009/09/20109/09/2010 115:025:02 The 1994 Group > The 1994 Group is established to promote excellence in university research and teaching. It represents 19 of the UK’s leading research-intensive, student focused universities. Around half of the top 20 universities in UK national league tables are members of the group. > Each member institution delivers an extremely high standard of education, demonstrating excellence in research, teaching and academic support, and provides learning in a research-rich community. > The 1994 Group counts amongst its members 12 of the top 20 universities in the Guardian University Guide 2011 league tables published on the 8th June 2010. 7 of the top 10 universities for student experience are 1994 Group Universities (2009 National Student Survey). In 17 major subject areas 1994 Group universities are the UK leaders achieving 1st place in their fi eld (THE RAE subject rankings 2008). 57% of the 1994 Group's research is rated 4* 'world- leading' or 3* 'internationally excellent' (RAE 2008, HEFCE). > The 1994 Group represents: University of Bath, Birkbeck University of London, Durham University, University of East Anglia, University of Essex, University of Exeter, Goldsmiths University of London, Institute of Education University of London, Royal Holloway University of London, Lancaster University, University of Leicester, Loughborough -
24, 2021 Program Book Table of Contents
June 21 – 24, 2021 Program Book Table of Contents Genetics Society of America . 3 Conference Organizers . 5 International C. elegans Board 2021 . 7 Sponsors . 9 Schedule of Events . 11 General Information . 16 Conference App . .. 17 Oral Presenters . 17 Poster Presenters . 17 Viewing Oral Sessions . 18 Attending Live Poster Sessions . .. 18 Live Poster Session Schedule . 19 Sponsor and Exhibitor Education Sessions . 21 Daily Meet-ups via Zoom and Remo . 22 Viewing Virtual Posters on the App . 23 Slack Chat Channels . 23 Job Postings . 23 Presenting Author Index . 23 Conference Policies . 24 Exhibits . 27 Oral Presentation and Workshop Session Listings . 29 Poster Session Listings . 58 23rd International C. elegans Conference | 2 Genetics Society of America Genetics Society of America GSA is an international scientific society representing more than 5,000 researchers and educators around the world. As well as connecting researchers through conferences and career programs, we publish two peer- edited scholarly journals, GENETICS and G3: Genes|Genomes|Genetics. We encourage you to join GSA so you can make use of exclusive member benefits and get involved in the Society’s many programs, including professional development training, awards, advocacy, and more. Join us as we work to advance the field and serve our community. Visit genetics-gsa.org for more information. GENETICS has been innovating since 1916, publishing high quality original research across the breadth of the field. G3: Genes|Genomes|Genetics is an open access journal that publishes high quality, useful results regardless of perceived impact. 2021 GSA Board of Directors Officers Directors Journal Editors Hugo Bellen, President Swathi Arur Brenda J. -
The British Innovation Fund Investing in the Best of UK University Venturing
The British Innovation Fund Investing in the Best of UK University Venturing For discussion purposes with Professional Investors only 2Q 2020 BRITISH INNOVATION FUND EXECUTIVE SUMMARY Key Areas of Specialty: Agricultural Bio- Technologies technology The BIF has been backed by some of The BIF is managed in the leading local The British Innovation partnership with government pension Deep Tech Life Sciences Milltrust International LLP Fund (BIF) is an schemes in the and Milltrust Agricultural AIFMD-compliant United Kingdom patient capital venture Investments, and supported by an capital fund investing in cutting edge spin- Alternative Advisory team of Nano Tech investment specialists outs emanating from Protein and agricultural and leading UK university research. scientific experts. 2 INVESTMENT PREMISE “Exploration is the engine that drives innovation. Innovation drives economic growth.” - Edith Widder 3 INVESTMENT PREMISE A BRIEF HISTORY OF BRITISH INNOVATION Sir Isaac Newton, PRS 25 December 1642 – 20 March 1726 Sir Alexander Fleming, FRS FRSE FRCS English mathematician, physicist, astronomer, 6 August 1881 – 11 March 1955 theologian, and author widely recognised as one of the Scottish biologist, physician, micro-biologist, most influential scientists of all time and as a key figure and pharmacologist. Inventor of Penicillin. in the scientific revolution. Edward Jenner, FRS FRCPE FLS John Logie Baird, FRSE 17 May 1749 – 26 January 1823 13 August 1888 – 14 June 1946 English physician who was a contributor to the Scottish engineer and innovator. One of the inventors of development of the smallpox vaccine. the mechanical television. Michael Faraday, FRS 22 September 1791 – 25 August 1867 John Adrian Shepherd-Barron, OBE English scientist who contributed to the study 23 June 1925 – 15 May 2010 of electromagnetism and electrochemistry. -
Crp-Brochure-080518-Na-Web.Pdf
Where Life Meets Science Where Life Meets Science “Research excellence is one of the The Park offers a flexible and fostering CHESTERFORD RESEARCH PARK Building on 60 years of continuous R&D at Chesterford is being developed as a 250 Foreword defining features of the Cambridge environment for both established R&D PROVIDES A SUPERBLY FLEXIBLE Chesterford, innovative biotechnology and acre low density scheme. To date, more landscape. Both academically and in companies and start-ups alike, providing AND FUTURE PROOFED pharmaceutical occupiers thrive in than 300,000 sq ft of laboratory and R&D the transfer of knowledge through to cutting-edge research facilities within a state-of-the-art accommodation and enjoy space has been let and occupied. Further ENVIRONMENT FOR BOTH EARLY commercial application, our region has community that encourages collaboration modern, central facilities, all set within a phases of construction are proposed to STAGE AND ESTABLISHED R&D established an international reputation at every stage. Chesterford Research Park unique and idyllic parkland location. extend the development to approximately that attracts outstanding academics, will help ensure that Cambridge ideas COMPANIES 1 million sq ft. researchers and business leaders who continue to change the world.” collectively drive discovery in so many different spheres. The depth and amazing Professor Sir Leszek Borysiewicz diversity of that research capability is Vice-Chancellor of the University of Cambridge. apparent at Chesterford Research Park. (Retired 2017) -
Trends and Challenges in Computational RNA Biology Alina Selega and Guido Sanguinetti*
Selega and Sanguinetti Genome Biology (2016) 17:253 DOI 10.1186/s13059-016-1117-7 MEETINGREPORT Open Access Trends and challenges in computational RNA biology Alina Selega and Guido Sanguinetti* Abstract complemented by two lively poster sessions, where partic- ipants had an opportunity to engage with over 40 posters A report on the Wellcome Trust Conference on during evening drinks receptions. Computational RNA Biology, held in Hinxton, UK, on In this report, we briefly recount the content of the 17–19 October 2016. conference by providing condensed, headline-style sum- Keywords: RNA, Review, Computational biology maries of the research described in the talks and some posters. Within the scope of this brief report, we cannot possibly do justice to the wealth and breadth of material Introduction presented and we will not be able to mention much inter- Recent years have witnessed a profound shift in our esting research, particularly within the poster sessions. understanding of RNA biology. Several novel biochemical We would like to stress that omissions in this report are and sequencing techniques are producing vast amounts not based on quality, but simply on a personal judgement of data that fundamentally challenge the textbook view as to what material could be most coherently presented in of RNA as a simple intermediate step of gene expression, a very limited space. revealing a wealth of unexpected new roles and shed- ding light on the complexity of the RNA world. While Transcripts the emerging picture unequivocally points to the cen- Perhaps the most remarkable discovery in modern RNA trality of RNA as a mediator of most cellular functions, biology is the realization of the diversity of the transcrip- the richness and heterogeneity of modern datasets pose tome. -
SWW SIA Annexes
South West England and South East Wales Science and Innovation Audit Annexes A–F Annex A: Consortium membership, governance and consultation Annex B: Universities, Colleges and Research Organisations Annex C: LEPs and Local Authorities within SIA area Annex D: Science Parks and Innovation Centres Annex E: Theme Rationale Annex F: LEP / Welsh Government Strategic Alignment A Science and Innovation Audit Report sponsored by the Department for Business, Energy and Industrial Strategy A–F Annex A: Consortium membership, governance and consultation Consortium Membership The following organisations were members of the South West England and South East Wales Science and Innovation Audit consortium, and were consulted during the development of the Expression of Interest, and subsequently during the SIA process. Business Aardman General Dynamics UK AgustaWestland / Finmeccanica Gooch & Housego Airbus in the UK Goonhilly Earth Station Ltd. Airbus Defence & Space (formerly HiETA Technologies Ltd. Cassidian) Airbus Group Innovations UK Huawei Airbus Group Endeavr Wales Ltd IBM Global Business Services Andromeda Capital IQE plc BAE Systems Johnson Matthey plc BBC Oracle Boeing Defence UK Ltd. Ortho Clinical Diagnostics Bristol is Open Ltd. Renishaw Broadcom UK Rolls Royce Centre For Modelling and Simulation South West Water ClusterHQ Toshiba Research Cray Watershed EDF Energy R&D UK Centre Wavehub First Group plc LEPs Cornwall and Isles of Scilly LEP Swindon and Wiltshire LEP GFirst (Gloucestershire) LEP West of England LEP Heart of the South West