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(Original image courtesy: Professor Douglas Kell, University of Manchester) 712399 +44 (0) 1249 108 Studio production: and Design Biotechnology and Biological Sciences Research Council

Annual Report & Accounts

2005-06

Presented to Parliament by the Secretary of State, and by the Comptroller and Auditor General, in pursuance of Schedule 1, Sections 2 [2] and 3 [3] of the Science and Technology Act 1965.

Ordered to be printed by the House of Commons 13 July 2006

HC 1270 LONDON: The Stationery Office £16.25 BBSRC Annual Report & Accounts 2005-06: Management Commentary Astronomy Research Council Research Astronomy & Physics Particle Research Council Natural Environment Medical Research Council Research Council Economic &Social Sciences Research Council Engineering &Physical Research Councils the of Laboratory Council for the Central Research Council Biological Sciences Biotechnology & Research Council Arts &Humanities UK (RCUK): Research Councils Councils through sister Research partnership with BBSRC works in across the biosciences ( biosciences the across funder of basic and strategic research Royal Charter in1994, isthe UK’s principal Research Council (BBSRC), established by The Biotechnology and Biological Sciences September 2005. awards, which BBSRC introduced in account of fulleconomic costing for grant take to adjusted have been Report the about/pub/policy/delivery.html Delivery Plan 2005-08 ( meeting the objectives of the BBSRC This Annual Report records progress in public engagement in bioscience. in engagement public in support of bio-based industries and training and to promote knowledge transfer support high class science and research Innovation (OSI). BBSRC’s mission isto through the Office of Science and It isfunded primarily by the Science Budget himnDeputy Chairman and Chief Executive Professor Julia Goodfellow CBE Chairman Dr Peter Ringrose Technology Act 1965, submits the following Report on its activities during the period 1April 2005 to 31 March 2006. The Biotechnology and Biological Sciences Research Council, as required by Schedule 1to the Science and www/bbsrc.ac.uk/ www.bbsrc.ac.uk ). Figures in BBSRC EPSRC PPARC CCLRC NERC AHRC ESRC MRC ). Contents nulAcut 41 39 35 Annual Accounts report Remuneration Boards, Panels and Committees 32 28 Financial and other information 22 Embedding our science insociety Enhancing exploitation of research outcomes 4 2 1 A healthy UKscience base Chief Executive’s report Chairman’s statement uios34 33 34 33 33 33 32 32 32 32 33 32 Auditors board Audit 31 Council Creditor payment policy Pensions 26 Developments since 31 March 2006 Financial highlights 30 Environmental policy 24Health and safety Risk management 19 Research Council harmonisation Efficiency Schools and young people 20 14 Opinion gathering and public dialogue 16 15 Education and training 10 22 research of Commercialisation 8 Technology Strategy and collaborative research with industry 4 UK facilities and infrastructure staff BBSRC 1 Studentships and Fellowships 6 development career and Training science International Scientific priorities Sponsored institutes Multidisciplinary and cross-Council research Healthy disciplines Council membership -cec rgam 21 20 13 12 e-Science Programme 10Research Equipment Initiative Animal health and welfare Plant research and crop science Integrative and systems biology 1 BBSRC Annual Report & Accounts 2005-06: Management Commentary disciplines, and between academic scientists and those working in working those and scientists academic between and disciplines, an important is undoubtedly This industry. in R&D and strategic context, broadest in its UK bioscience of strength the of determinant quality highest the to Commitment future. the for well augurs it and is an scientists for development career early and training research prominent. is particularly consensus this where an area of example Chief BBSRC the to gratitude Council’s the record to I am pleased closely worked have who all those and Goodfellow, Julia Executive, the and Committees Boards, the – including BBSRC across her with I would year. the over work hard all their – for institutes sponsored insights their for Members Council the thank personally to like also year. the throughout advice and S Ringrose Dr Peter Chairman 2006 July GlaxoSmithKline College Veterinary Royal Independent Manchester of University Dundee of University Ltd Inpharmatica (observer) Industry and Trade of Department OSI, Chairman Executive Chief and Chairman Deputy HRI Warwick Farms Brightman Affairs Rural and Food Environment, for Department London College University Warwick of University Birmingham of University Cambridge of University Industry and Trade of Department [as at 1 April 2006] 1 April at [as University of Manchester, also served on the Council during 2005-06. 2005-06. during Council the on served also Manchester, of University Dr Malcolm Weir Weir Dr Malcolm Neilson Mr John Professor A Jackie Hunter Hunter A Jackie Professor McKellar Quintin Professor Penman Dr Alistair FRS Rothwell Nancy Dame Professor FRS CBE Tickle Cheryll Professor Professor David Delpy FRS Delpy David Professor Professor Robert Freedman FREng Fryer Peter Professor Gilligan Chris Professor Haywood Mrs Sarah Dr Peter Ringrose Ringrose Dr Peter CBE Goodfellow Julia Professor Bright Simon Professor Brightman Dr David FRS Dalton Howard Professor

Professor Douglas Kell, Douglas Professor Council membership membership Council

I am very pleased to record that BBSRC has had an outstanding an had has BBSRC that record to pleased I am very In BBSRC we deal with some of the most exciting and fast-moving and exciting most the of some with deal we In BBSRC new and bioinformatics as such areas like which, science, of areas hungry. resource are increasingly technologies, and tools research UK the with work and upon draw to are able we that pleased I am very In challenges. such in addressing community research bioscience the and in ideas synergy the by encouraged I am very addition different the across see we that purpose of sense common One of the strongest features this year has been the increase in increase the been has year this features strongest the of One of auspices the under working interdisciplinary and cross-Council positive many generated has UK (RCUK), which Councils Research in also but science, new of in terms only not outputs, innovative and engagement in public and transfer in knowledge training, research science. with year in meeting its objectives across the board, for example: in example: for board, the across objectives its in meeting year new in innovative training; and research top-class for support developing and in evolving business; and industry with partnerships societal wider the to in contributing and base UK bioscience the is particularly It challenges. and opportunities scientific about debate financial a strict within done been has this that noteworthy are already we that savings generated has which framework, research. frontline fund to re-directing Chairman’s statement Chairman’s 2 BBSRC Annual Report & Accounts 2005-06: Management Commentary Chief Executive’s report refocusing around anew science strategy in2004-05), 45 were Institute for Animal Health isbeing assessed in2006 following its programmes assessed across sixof our sponsored institutes (the The 2005 Institute Assessment Exercise found that, of the total of 55 institute sectors (page 5). world-class science supported by BBSRC inboth the university and biological sciences. This Annual Report gives several examples of the UKhas now moved ahead of the USA inpre-clinical &health and and that specifically inthe area of high impact research publications outcomes, the UKremains second only to the USA inthe biosciences, funding/psa_metrics_report.pdf) showed that, interms of indicator research base, published in2005 (www.ost.gov.uk/research/ Innovation’s (OSI’s) Evidence report on the performance of the UK borne out by firmdata. For example, the Office of Science and Naturally we areencouraged that our confidence inUKbioscience is addressing wider societal aspirations and concerns. industry; underpinning industrial and commercial innovation; and highly skilled individuals needed inacademic research and UKbio- the providing competitiveness; international and excellence scientific bioscience base inways that willbe sustainable interms of: For this reason we can be confident that we aredeveloping the issues and challenges inbiosciences and to develop away forward. policymakers and the wider public, to achieve aconsensus on the big from researchers, business and industry leaders, as well as reflects the extent to which we have been able to draw upon insights This integration ismuch more than anadministrative arrangement. It partnerships and training. and crop research, with ring-fenced support for industrial we arecomplementing science-driven initiatives, for example inplant grants, and through anew dedicated training programme. Similarly, collaborations and support through individual responsive mode university-based centres, European partnerships, cross-institute approach to bioscience through further large scale investment in context. We have, for example, taken forward our vision of asystems its broadest bioscience in the community UK that serves effort many different activities to provide anunparalleled coordination of provide afocus around which we have successfully channelled our scientific, business and policy needs of our stakeholders. These this has been our success inidentifying core priorities that meet the delivering our vision for 21st century bioscience inthe UK.Central to and developing in change step a made have we which on evidence evaluations and consultations that have provided us with the The year 2005-06 has seen the culmination of several reviews, Sustainability Study (RIPSS) Steering Group (2004). * Final Report of the Research Council Institute and Public Sector Research Establishment institutes (page 8). our ten year vision for Science and Innovation inBBSRC-sponsored those areas Ihave indicated above. InNovember 2005, we published how we willtake forward our priorities over this period, including in In May 2005, we published our 2005-08 Delivery Plan, which details the challenges of science funding. programme where Iwas delighted to accept aninvitation to speak on organisations, and through the Royal Institution’s discourse scrutiny and questioning by any interested individuals and community through our annual Open Meeting, at which we invite consultations; and for opportunities to present our vision to the wider I amalso grateful to allwho have taken inreviews part and grant awarding Committees, was highly constructive and productive. Council and Strategy Board, Institute Directors and Chairs of our priorities and future directions were shared by members of our joint strategy meeting insummer 2005, inwhich discussions on BBSRC’s consultation and planning procedures during the year. Our I amextremely grateful to allof those who have contributed to these into our planning. mathematical bioscience inthe institute-base, so that we can build year on microbiological sciences, bioenergy (pages 6and 12), and outputs from new reviews that we have commissioned during the science that isrecognised as world-leading. Ilook forward to the and livestock genomics (pages 12 and 13) we areagain building on In taking forward recommendations from our reviews on crop science from Defra inline with the RIPSS* principles. the highest level and areseeking to secure strategic investment serious threat to sustainability. We arecontinuing to pursue this at Department for Environment Food and Rural Affairs (Defra) pose a institutes, current and projected falls incontract income from the governance arrangements for institutes (page 9).For several Institutes’ Governing Bodies and Directors to determine the future forward institute science (page 8).We arecontinuing to work with investment and new strategic research alliances that willtake major planned have we which on base evidence strong a provided of science or outstanding/good on strategic relevance. This has judged as either high international/international quality on the quality 3 BBSRC Annual Report & Accounts 2005-06: Management Commentary Chief Executive’s report Executive’s Chief The Research Councils are increasingly Councils Research The knowledge promote to together working of commercialisation the and transfer www.rcuk.ac.uk/ outputs. research documents/addingvalue.pdf 22) and science in society science 22) and 29). (page activities major Increasingly, in the challenges are becoming biosciences that research to amenable scientific crosses different and disciplines, in levels organisational bioscience, from molecules and cells to and organisms whole is This populations. growing in our reflected research collaborative sister our with portfolio are We Councils. Research with these supporting harmonised increasingly mechanisms support 32). RCUK (page within have we year, the During collaborative this introduced approach into new partnerships international This 14). and 12 (pages bringing and countries, in other agencies with co-funding includes Human the for support through researchers early-career together Biology Molecular European the and Program Science Frontiers Organisation. partnerships research new about enthusiasm with write to is easy It of multidisciplinarity new the are supporting which centres, and bioscience research and helping to provide longer-term sustainability. brings inevitably change that underestimate however, not, I do the to funding of withdrawal the as such in cases and, uncertainty a has 2006, in March closed which (SRI), Institute Research Silsoe BBSRC lives. personal and professional people’s on impact major that and are minimised, impacts such that ensure to hard works to I am pleased science. UK from lost are not expertise skills and is being SRI from expertise and knowledge of deal a great that report 19). (page mechanisms of a variety through retained CBE Goodfellow Julia Professor 2006 3 July Basic bioscience contributes significantly to our to significantly contributes bioscience Basic BBSRC that 7). I am delighted (page ageing of understanding been FRS has CBE Partridge Linda Fellow Professorial into Legend-Research Living Aged the a Help with recognised the Majesty Her from received she which award, Ageing in the pioneer is a world-leading Partridge Professor Queen. organism. a model as fly fruit the using ageing, of genetics BBSRC’s Open Meeting in Manchester Town Hall in February 2006 in February Hall Town in Manchester Meeting Open BBSRC’s A twin theme during 2005-06 – matching the integration of support of integration the – matching 2005-06 during theme A twin in integrative, increase the been – has bioscience for mechanisms These approaches. Council cross-Research and multidisciplinary (page transfer 6), knowledge (page funding research encompass Collaborative research and research training in partnership with in partnership training research and research Collaborative our Through business. our of elements key remain industry track our on are building we Panel Strategy Industry for Bioscience the and transfer in knowledge and areas, in these record 22 – 27). (pages outputs research of commercialisation A healthy UK science base Healthy disciplines

We have introduced several measures to ensure that the UK Councils, and by moving to four funding rounds each year from July remains an attractive location for bioscience research and so retains 2005. We introduced grant funding at full economic cost from its world-leading research community. These cover increased September 2005. funding, including money for new research tools and equipment and access to facilities, as well as support that enables researchers to Progress in the biosciences depends increasingly on researchers sustain critical mass and impact by crossing traditional having access to new technologies and costly state-of-the-art organisational and discipline boundaries in new collaborative and facilities. We are addressing this in several complementary ways to multidisciplinary partnerships. We are implementing our announced ensure that bioscientists in the UK can remain at the cutting edge. commitment to increase our responsive mode funding by at least 4% For example, we have announced a major investment of a further p.a. over the period to 2007-08. This funding enables researchers to £23M for research on new tools and resources to advance bioscience explore new ideas in basic curiosity-driven research, wherever they (page 20); we are continuing our funding stream for research arise, and is crucial in attracting and retaining high calibre scientists equipment; and where appropriate, we are working with other in the UK. It provides agility, enabling scientists to seize new funders. For example, in partnership with the MRC and the Wellcome opportunities rapidly and to establish a leading position. We have Trust, we are investing a further £950k in the European simplified and increased the flexibility of our procedures, to help Bioinformatics Institute to help ensure that scientists in the UK retain reduce the amount of scientists’ time taken up in applying, by access to leading-edge facilities for analysing the massive amounts of introducing electronic submissions jointly with other Research biological data being generated around the world.

Research Funding Analysis of Gross Expenditure 2005-06: Management Commentary Commentary Management 2005-06: (£M) Universities BBSRC-sponsored Other Organisations* TOTAL Institutes Responsive Research Grants 101.25 8.99 5.14 115.38 Core Strategic Grants (CSG) - 66.57 - 66.57 Accounts Accounts Research Initiatives 33.95 6.23 5.07 45.25 & Equipment and Facilities 11.44 0.90 0.62 12.96 Capital and Buildings 0.03 19.45 5.22 24.70 Training Awards and Fellowships 35.83 2.48 0.82 39.13 182.50 104.62 16.87 303.99 *Includes other Research Councils Annual Report Report Annual Summary of grant applications and success rates 2004-05 2005-06 BBSRC Spring Autumn Spring Autumn Winter Number 892 998 776 668 404 % success 25 26 25 27 25 4 Application and success rates by gender Percentage of successful applications from total applications 2003 2004 2005 Male Female Male Female Male Female Project grants 28.3 25.0 26.3 24.1 27.0 24.5 Programme grants 35.2 31.8 44.9 37.9 42.9 39.7 New investigators 34.6 19.2 41.8 50.0 40.8 33.3 Fellowships 11.5 12.8 9.3 17.4 16.9 5.6 Percentage of female applicants for peer reviewed funding 2003 2004 2005 Project grants 19.7 19.8 21.4 Programme grants 17.5 14.1 19.4 New investigators 24.3 21.2 29.7 Fellowships 31.0 32.2 35.6

* Council for the Central Laboratory of the Research Councils

5 BBSRC Annual Report & Accounts 2005-06: Management Commentary

A healthy UK science base UK science A healthy Reprinted by permission from Macmillan from permission by Reprinted Nature (2006) 440, 224-227 (2006) Nature Nature (2006) 440, 535-539 (2006) Nature New information about the structure and workings of a gene of workings and structure the about information New Identification of a gene in rice blast fungus that is essential that fungus blast in rice a gene of Identification Systematic protein analysis of the flagellum, the structure the flagellum, the of analysis protein Systematic Scientists have found a surprisingly common mutually common a surprisingly found have Scientists Stem cell research is providing insights into the evolution of evolution the into insights is providing research cell Stem during the year. year. the during appear to get from bacteria, in return providing fixed carbon. fixed providing in return bacteria, from get to appear Kent) and Cambridge of (Universities complex that stops the chromosomes of wheat and some other some and wheat of chromosomes the stops that complex offers relatives, wild of those with effectively pairing from crops with varieties new developing for prospect realistic first the Centre) Innes (John drought. to tolerance as such traits 749-752 439, (2006) beneficial relationship in aquatic ecosystems. More than half of half than More ecosystems. in aquatic relationship beneficial B vitamin of source an external require all algae for its ability to infect rice plants opens up the possibility of possibility the up opens plants rice infect to ability its for (University infection. control to fungicides targeted developing Exeter) of that allows the sleeping sickness parasite to move, has move, to parasite sickness sleeping the allows that organism’s the for are essential that proteins some identified potential them - making bloodstream human survival in the Manchester Lancaster, of (Universities drugs. novel for targets Oxford) and neck and shoulder tissues in vertebrates, as well as the origins the as well as in vertebrates, tissues shoulder and neck Chiari’s and Syndrome Klippel-Feil as such diseases human of infant sudden of quarter a about for account that malformation London) College (University cases. syndrome death 347-355 436, (2005) A striking feature of much of the UK’s world-class bioscience is bioscience world-class UK’s the of much of feature A striking that, whether undertaken in universities or within strategically within or in universities undertaken whether that, of enhancement the combines often it institutes, focused relevance practical with understanding and knowledge fundamental to change, climate of impact the - from challenges contemporary to is This healthcare. human to population, world a growing feeding in published research BBSRC-supported the of some by exemplified Nature 7. 43 4.14 4.14 5.12 5.74 1.77 1.81 4.37 3.76 2.63 2.57 4.53 8.28 2.27 2.91 2.35 2.07 8.50 3.02 6.03 6.50 3.04 2.98 11.37 12.38 (£M) Research and grants capital - Top 25 Universities Universities 25 - Top 2003-04 2004-05 2005-06 University Dundee London College King's Southampton Cardiff Aberdeen Leicester Andrews St Newcastle upon Tyne upon Newcastle York Anglia East Liverpool Warwick Nottingham London College University Bristol Leeds Birmingham Glasgow London College Imperial Oxford Edinburgh Sheffield Manchester Manchester Cambridge Bath BBSRC funding to Universities Universities to funding BBSRC funding grant by Analysis of final reports on grants on reports final of Analysis 25 22 23 24 18 19 20 21 13 14 15 16 17 8 9 10 11 12 3 4 5 6 7 1 2 Research grants delivering delivering grants Research adding work class high knowledge to significantly (%) field in the 75 77 78 6 BBSRC Annual Report & Accounts 2005-06: Management Commentary Multidisciplinary and cross-Council research development, at the University of Nottingham. interactions between fluorescently-labelled proteins during pollen nanotechnology, at the University of Edinburgh, to measuring the from cosmology for molecular structural determinations in month projects. The topics supported range from using parameters Analysis’, and have made eight grants totalling just under £1Mfor 18- launched aninitiative in‘Innovative Biological Imaging and Signal with the Particle Physics and Astronomy Research Council, we opportunities for collaborative new science. From such apartnership together researchers from different disciplines to identify new Councils. research through collaborative programmes with our sister Research approaches (page 10). We arealso facilitating multidisciplinary bioscience research. Aprime example isour focus on systems to tackle complex biological problems iscentral to our vision of A healthy UKscience base Cross-Council programmes: (Research on ageing isanother cross-Council area) - - - - Bringing together researchers from different scientific disciplines algae that were not possible previously with confocal studies. and nuclear-associated calcium ion signals inmulti-cellular events, including sperm-egg pronuclear fusion, S-phase onset new technology isallowing the group to obtain images of nuclear photon system for spatial imaging of events inside cells. This Researchers at the Marine Biological Association areusing a2- pigmented egg using fluorescently labelled sperm. These images were obtained inthis optically dense and highly moving towards the egg pronucleus during fertilisation of a An overlay of three sequential images of the sperm pronucleus (arrows) Rural Economy and Land Use Brain Science Stem Cells Biology Systems BBS RC hasRC pioneered ‘brokering workshops’ to bring Fucus egg. for future development of bioenergy. stepfirst identifyingin scientific priorities that offer the best options Kell, of how basic bioscience can contribute to renewable energy, as a conducted areview, under the chairmanship of Professor Douglas mobilising the long-term potential of bioenergy”. BBSRC has systems approach to analysing bioenergy demand and supply; Sustainable Energy Economy Programme. The project is“A whole London under the renewable energy theme of the Towards a consortium project (£2.5M)led by scientists at Imperial College Research Council (MRC). tomorrow’s treatments, inpartnership with and the EPSRC Medical applications. BBSRC funds several areas of research that willunderpin device or process for exploiting it, and translation into clinical approaches –typically, anunderlying biological principle, aphysical of the initiative grants. Research Council contributed (EPSRC) over £730k insupport of four (University of Cambridge). The Engineering &Physical Sciences to build chemical tools for biology from 'molecular fragments' chemical inhibitors (Cardiff University); and using anovel approach causes of premature ageing inWerner syndrome cells using selective embryonic stem cell cultures (University of Sheffield); identifying agents, and their molecular targets, that determine the fate of Systems initiative. Grants include support for identifying chemical £10M, under our Selective Chemical Intervention inBiological chemistry and biology, we made the first twenty grants, totalling rapid and inexpensive way of making tissue-like ‘grafts’ out of BBSRC isco-funding (£650k) with alarge and NERC EPSRC Advances inhealthcare often require multidisciplinary of our part As support for research at the interface between collagen and using them to introduce cells to repair diseased or damaged tissues. (University College London, Queen Mary Queen London, College (University tissues. damaged or have also supported multidisciplinary approaches through Bioreactor Sciences Project, researchers have developed a In addition to these partnerships with other funders, we Supported by the £1MBBSRC and EPSRC-funded Tissue our sponsored institutes (page 8)and centres for integrative systems biology (page 10). and Imperial College London). 7 BBSRC Annual Report & Accounts 2005-06: Management Commentary A Healthy UK science base UK science A Healthy Climate change research; and Research for education. education. for Research and research; change Climate We contribute to the Local Authority Research Council Initiative Council Research Authority Local the to contribute We In June 2005, in partnership with the Natural Environment Research Environment Natural the with in partnership 2005, In June the of outcomes the presented we Defra, and (NERC) Council a over and media the to (2000) Flow Gene on programme BBSRC/NERC a at regulators and NGOs policymakers, including stakeholders hundred meeting. discussion special Traditionally, research on ageing has focused on single on focused has ageing on research Traditionally, BBSRC contributed to a Research Councils UK exhibition at the 2005 the at UK exhibition Councils a Research to contributed BBSRC Cells-Progress Stem Embryonic “Human Symposium, International Therapy”. Cell Towards and the Authorities. Seminars that form part of this have included: have part this of form that Seminars Authorities. the and (LARCI) that facilitates knowledge exchange between the Councils the between exchange knowledge facilitates (LARCI) that disciplines, for example on biological changes associated with associated changes biological on example for disciplines, to aids mobility as such devices engineering or age, increasing venture, new In an innovative decline. age-related for compensate this approach; joined-up a more funding EPSRC and are jointly BBSRC field, the within direction switch to researchers enabling at is aimed totalling grants, thirteen first The researchers. new attracting and the programme, this under made been have £500k, under just (SPARC). Research Ageing of Promotion Strategic The role of ageing, alongside that of diet and other environmental in explored is being gut cancers, of development the on factors, with Research Food of Institute the at research collaborative Proteomic Newcastle. of University the at clinicians and scientists as act could that changes indicate cells mucosal of analyses susceptibility. individuals’ of biomarkers When the protein Notch is active most embryonic stem cells turn into turn cells stem embryonic most is active Notch protein the When (pink). cells stem as remain they it, without (green); cells nerve BBSRC is leading for the Research Councils in establishing a UK in establishing Councils Research the for is leading BBSRC Scientists at the Institute for Stem Cell Research (ISCR) at the at (ISCR) Research Cell Stem for Institute the at Scientists that (Notch) a protein discovered have Edinburgh of University the of cells become to cells stem embryonic unspecialised directs MRC, BBSRC, by funded research from finding, This system. nervous 6 project) Framework (an EU EuroStemCell with Trust Wellcome The scientists ISCR by made discoveries of a series of latest the is among the for way the is paving which cells, stem of biology the about modelling as such uses for cells stem of growth laboratory controlled drugs. new of effects the testing and diseases Sixteen research projects totalling £6M have been funded under the under funded been £6M have totalling projects research Sixteen is Each initiative. Engineering and Science Cell BBSRC/EPSRC Stem in advances parallel for need the reflects and BBSRC, by 75% funded them manipulate to able in being and biology cells’ the understanding include: Examples environments. of in a range precision with stem of storage frozen long-term for potential the into exploration of effectiveness the improve to scaffolds engineered of use the cells; and marking for technology new and repair; in brain cells implanted cells. stem tracking Stem Cell Cooperative to facilitate links between researchers and researchers links between facilitate to Cooperative Cell Stem research cell stem national an integrated of development encourage Initiative) Cell (UK Stem Pattison the to in response community, and activities the on community the with Consultation Report. the leading is also BBSRC is underway. Cooperative the of management scientists. cell UK stem for training communications focused of provision 8 BBSRC Annual Report & Accounts 2005-06: Management Commentary of Edinburgh, Scottish Agricultural College, and other centres. the Institute for Animal Health, alongside research at the University undertaken at the Roslin Institute and the Neuropathogenesis Unit of animal bioscience inthe UKto encompass research currently funding for anew facility (EBRC). This would provide amajor focus for Report, we have announced our intention to invest £35M incapital the Institute for Animal Health that we recorded inlast year’s Annual investment of £23M inre-development of the Pirbright Laboratory of Institutes –The Next Ten Years”, and inaddition to the BBSRC presagedAs in“Science and Innovation inBBSRC-sponsored modernisation and improvement of institute infrastructure. the decade from 2004-05 to 2015. This willenable rationalisation, Equipment strategy, with planned investment of over £200M over expertise and resources. We have established anEstates and provide specialist, long-term, and insome cases unique, experimental and Sustainable Agriculture and Land Use. Institutes characteristically research: Animal Health and Welfare; Biomedical and Food Sciences; capacity and trained people inthree overarching strategic areas of institutes.html) sets out how they willprovide new knowledge, sponsored institutes (www.bbsrc.ac.uk/about/pub/policy/ Sponsored institutes A healthy UKscience base BBSRC-sponsored institutes Institute of Food Research (IFR) Babraham Institute (BI) Biomedical and Food Sciences Roslin Institute (RI) Institute for Animal Health (IAH) Animal Health and Welfare Rothamsted Research (RRES) Institute of Grassland and Environmental Research (IGER) John Innes Centre (JIC) Sustainable Agriculture and Land Use Our ten year vision for science and innovation inBBSRC- and advice for Government. providing independent research knowledge transfer; and excellencescientific and based economy; Linking Supporting the knowledge- capability; national crucial institute science in: Providing illustrates the contribution of strategyOur document in the future. single funding stream for multiple sites across these two institutes and BBSRC Council has indicated that it isminded to move to a Grassland and Environmental Research and to Rothamsted Research; collaborations. We willincrease total core funding to the Institute of grants with university-based scientists, to promote further Rothamsted Research, we have waived the limit on income for joint these institutes, and for the Institute of Food Research and Innes Centre inrecognition of their scientific excellence; and for increase total core funding to the Babraham Institute and to the John animal health and welfare, from 22%to 26% by 2009-10. Also, we will an increase inthe proportion of core institute funding that supports 2007-08, excluding capital funding. Other significant changes include funding to institutes of £11M on arecurrent baseline of £63M by 2006-07 to 2009-10. This willinclude anoverall increase inBBSRC Institute Assessment Exercise, we announced institute funding for In February 2006, and following the outcome of the 2005 Honeybee equipped with aradar transponder published in bees to foodsources. The results were disputed theory that ‘waggle dances’ direct sometimes the supports that evidence new tracked honeybees with radar and found Scientists at Rothamsted Research have 435, 205-207). Nature in May 2005 (Nature 9 BBSRC Annual Report & Accounts 2005-06: Management Commentary (green) M. bovis M. A healthy UK science base UK science A healthy , the cause of this disease. this of cause , the Bovine dendritic cells infected with with infected cells dendritic Bovine Mycobacterium bovis Mycobacterium shown that only a minor subset can be infected by infected be can subset a minor only that shown Research at the Institute for Animal Health could lead to lead could Health Animal for Institute the at Research immunity in cattle. Studies of bovine dendritic cells have cells dendritic bovine of Studies in cattle. immunity targeted vaccines for bovine tuberculosis through a better through tuberculosis bovine for vaccines targeted understanding of the biology of cells that trigger protective trigger that cells of biology the of understanding BBSRC is correctly implementing the findings of previous reviews by reviews previous of findings the implementing is correctly BBSRC longer are no these However, governance. institute on Government recognised 2006 in January OSI by published A review practice. best an commissioned have We changes. for called but progress, BBSRC chairmanship the under review, and appraisal options independent in report to is expected which FRS, Follett Sir Brian Professor of 2006. October Income Income* INCOME Funding cultivars on soil on cultivars Lolium CSG Funding FSA Contract Research International Sources REVENUE Capital and novel novel and Festuca InstituteOther BBSRC BBSRC Defra/ Industrial Other EC/ Other TOTAL BBSRC Institute funding (£k) funding Institute JICRRESTOTAL: Research Silsoe Institute**TOTAL Departments Government and Charities *Including 67,021 5,853 2006 4,271 March 31 3,512 1,024 **Closed 24,160 3,150 5,127 25,392 2,571 3,673 12,374 144 2,194 2,923 5,108 13,260 3,010 1,985 1,379 11,841 1,034 583 826 8,858 8,717 29,435 3,861 428 112 362 52 102 (13) 2,818 185 24,359 18,603 19,446 66,573 8,062 151,956 8,793 6,442 19,124 Biomedical and Food Sciences Food and Biomedical BIIFRTOTAL: Use Land and Agriculture Sustainable IGER 2,706 10,870 2,641 35,839 1,801 4,207 20,455 4,402 1,801 1,501 9,585 1,437 2,682 1,457 835 - 391 17,469 1,834 1,301 15,791 535 807 677 1,551 493 1,162 1,335 44420,048 2,147 7,128 3,725 156 580 5,220 Animal Health and Welfare and Health Animal IAHRITOTAL: 7,341 32,117 6,812 2,392 1,013 1,017 3,476 7,991 9,416 45,235 7,762 8,441 3,428 1,421 5,692 3,192 9,196 13,118 13,865 1,036 421 2,175 1,205 1,629 408 2,216 4,449 BBSRC is encouraging closer research collaborations between collaborations research closer is encouraging BBSRC programmes cross-institutes through cases in some institutes, has Research Rothamsted of Goulding Keith Professor 12). (page for Programme Cross-Institute the of director appointed been BBSRC-funded together brings which Function, Soil Sustainable of Institute the and Research Rothamsted at science soil on research of understanding advance to Research Environmental and Grassland already has It landscapes. in managed function soil sustainable including grants mode responsive interdisciplinary four secured in the nutrients of waters to release and mobilisation the on research and eutrophication; on this of impact the and biomass, microbial soil of influence the on structure and the variability of soil hydrological functioning. Integrated functioning. hydrological soil of variability the and structure in groups research with developed are being programmes research Hydrology. and Ecology for Centre NERC’s the with and Scotland 10 BBSRC Annual Report & Accounts 2005-06: Management Commentary the EPSRC. are being supported additionally by atotal of just under £5Mfrom Nottingham (root biology) and Oxford (signalling inbacteria). These centres, at the Universities of Edinburgh (cell processes); We have announced awards totalling over £22Mfor three further chemical engineer, from several European countries. included microbiologists, chemists, computer scientists and a Biology (MCISB) and mathematics. At the different countries and with backgrounds inbioscience, computing are among new posts that have attracted researchers from nine postdoctoral fellowships on the innate immune response to infection Integrative Systems Biology (CISBIC) scientists from Japan, Australia and China. At the Newcastle upon Tyne has built a40-strong team and attracted top Biology of Ageing and Nutrition (CISBAN) interacting biological processes. integration of mathematical and experimental data that describe biological form and function. At its essence isthe co-evolution and understanding of how genes and their resulting proteins give rise to growing a with era, post-genomics the of out emerged has provide this mixof skillsand expertise. The field of systems biology area by attracting the high calibre, multidisciplinary teams needed to beginning to realise their potential as world-leading centres inthis bioscience. BBSRC’s first centres for integrative systems biology are and conceptual skillswilldrive the next wave of innovation in Integrative and systems biology Scientific priorities A healthy UKscience base Professor Hiroaki Kitano of Sony Computer Science Laboratories Inc. jointly by BBSRC and EPSRC inMarch 2006. Keynote speaker was Over 70 researchers participated inaworkshop on Systems Biology, run It isrecognised worldwide that the combination of experimental , University of Manchester, new appointments have Manchester Centre for Integrative Systems The Centre for Integrated Systems at Imperial College London nine at the University of Centre for research community and internationally. potential of collegiate and systems approaches both within the UK Investigating Genome Function initiative (1999) to investigate the Arabidopsis We have provided additional funding to the research consortia on for support. environmental protection. We have received over thirty applications relevant to health, biotechnology, nutrition, bioenergy and to single cell organisms. It willfocus particularly on micro-organisms the resource necessary to develop aquantitative systems approach and Spain, seeks to pool expertise across these countries to create Norway Netherlands, the Austria, Germany, in partners with project, which we willcontribute up to £3Mover 5years. This collaborative programme on Systems Biology inMicro-organisms (SysMO), to We have announced our participation inaninternational Goodfellow and DrRichard Faragher. Miles of BBSRC and speakers Professor Janet Lord, Professor Julia Integrated Systems Biology of Ageing and Nutrition. From the left DrColin that helped to establish the biology component of the Centre for Research into Ageing (2001). These included aproject under the former totalled over £9M–the Science of Ageing (1998) and Experimental the outcomes of the 49 projects funded by two BBSRC initiatives that Research into ageing isaBBSRC priority area. InMarch 2006, we reported and Streptomyces , which were established under the 11 BBSRC Annual Report & Accounts 2005-06: Management Commentary Saccharomyces A healthy UK science base UK science A healthy , as a model organism. Yeast is highly amenable to amenable is highly Yeast organism. a model , as Yeast cells. Courtesy of David Coleman, UCD. Reprinted with permission with Reprinted UCD. Coleman, David of Courtesy cells. Yeast from SGM: Microbiology, 2004. Research at MCISB is demonstrating the principles and methods and principles the is demonstrating MCISB at Research of systems biology using the bakers’ yeast, cerevisiae so and technologies, high-throughput and manipulation genetic of characterisation the on is focusing work experimental initial with modellers will provide in turn which proteins, yeast purified major the of One action. of mechanisms enzyme predict to data e.g. information, of sources existing ‘mine’ is to challenges the with these integrate to and databases, sequence genome be will focus a further Therefore, data. experimental and models of elements different the of inter-operability workflow-based the on chain. data biology systems the the govern that changes cellular and molecular the of Studies CISBAN, at research of heart the are at ageing of processes basic are Scientists Tyne. upon Newcastle of University part the of progressive understand to in order cells stem adult assessing acquired, that shown have They tissues. in ageing damage example, For age. with sharply increase mutations ‘somatic’ have here, pictured gut, human in the cells stem ageing of studies the on cell stem in a single a mutation of effect the revealed Further (COX). c oxidase cytochrome enzyme the of production mathematical between collaboration close involving studies, to underway are now researchers, experimental and modellers individual from in mutations variation the predict, and analyse, tissues. ageing within cells (fluorescent green spots) green (fluorescent by immune cells will be used will be cells immune by Salmonella typhimurium Salmonella Salmonella typhimurium Salmonella Scientists at CISBIC at Imperial College London are aiming to are aiming London College Imperial at CISBIC at Scientists studies through research biology systems for a platform provide is to objectives main the of One interactions. host-pathogen of that methods hybrid develop and merits, relative the evaluate draw upon the strengths, of computer and mathematical example, For level. a biological at integration to prior sciences, food-poisoning the of uptake the on Centre the at research bacterium to develop rational and predictive models that will help in the will help that models predictive and rational develop to vaccines. animal and human improved of design Fluorescent labelling of COX subunit-1 (green) shows the absence of absence the shows (green) subunit-1 COX of labelling Fluorescent mutation a mitochondrial by caused brown), (centre, c oxidase cytochrome CISBAN). Greaves, Laura of (Courtesy colon human the of lining in the White blood cells, such as the macrophages pictured here pictured macrophages the as such cells, blood White engulfing response, immune in the role an important play (green/red) including bacteria, 12 BBSRC Annual Report & Accounts 2005-06: Management Commentary conditions. This could lead to adiagnostic test for organic produce. patterns of gene activity in wheat grown under organic or non-organic 10,000 wheat genes has been used to identify differences in new material and speed up the breeding process. Amicroarray of Advanta Seeds, areenabling plant breeders to rapidly characterise Bristol, incollaboration with scientists at Rothamsted Research and Molecular tools for wheat research, developed at the University of changed climate. counterpart genes inother species could lead to varieties adapted to its time of flowering. Using this information and that from expected barley gene that helps the plant measure daylength and so optimise For example, scientists at the John Innes Centre have discovered a research generating new knowledge relevant to crop improvement. During the year there have been many examples of BBSRC-funded societal value of crops. We are: readily drive research to increase the commercial, environmental and ensure that knowledge gained from basic plant science can more Crop Science, which reported in2004, by taking several steps to help Plant research and crop science A healthy UKscience base We have responded to recommendations of the BBSRC Review of in this area. up to afurther £1Mfor Industrial Partnership Awards (page 22) France over the next four years. collaborative crop research between scientists inthe UKand National de la Recherche Agronomique (INRA) to support broader strategy inthis area. framework for research on non-food crops and willinform a for work on genetic improvement of cereal and grass crops. Rothamsted Research and the Scottish Crop Research Institute and Environmental Research, the John Innes Centre, expertise, facilities and resources at the Institute of Grassland Area Network inPlant Genomics. Allocating up to £11.6M for aninitiative incrop science, and Reviewing bioenergy research which willprovide a Establishing MONOGRAM, aprogramme to bring together Acting as the UK’s managing partner inaEuropean Research Contributing £1.7M to apartnership with the Institut Raised levels of RN13 enhance plants’ ability to resist infection the size of plant cells and their direction of growth, factors that Arabidopsis protects itself against strong sunlight. The information isbeing modify their resistance response to different types of invading ultimately determine plant shape and structure. Collaborating to specific bacterial strains without requiring them to commit (JIC) have shown how individual genes influence and control Also using used as aguide to help breeders inSouth America and South signalling molecule from leaves, called florigen, which helps To develop effective new ways to control crop diseases we need to know more about how plants respond to attack by suicide –the normal response. Plants were also shown to bacteria by switching on genes indifferent combinations. genetically determined mechanism by which novel protein, RIN13 that occurs intiny amounts incells. disease-causing agents. Working with the model species Scientists at the University of Sheffield have identified a with scientists inGermany, JICresearchers identified a control the flowering season inplants and trees. East Asia to improve yield inbeans and rice. , scientists at Imperial College London have found a Arabidopsis , researchers at the John Innes Centre Arabidopsis 13 BBSRC Annual Report & Accounts 2005-06: Management Commentary A healthy UK science base UK science A healthy review panel, led a lively discussion. discussion. a lively led panel, review 2005 Royal Show, where Dr Graham Plastow of Syngen of Plastow Dr Graham where Show, Royal 2005 future directions in farm animal genomics research were research genomics animal in farm directions future Emerging findings from BBSRC’s consultation and review of review and consultation BBSRC’s from findings Emerging presented to industry representatives and researchers at the at researchers and representatives industry to presented International Ltd, who had been a member of the independent the of a member been had who Ltd, International Many of the challenges in this area are international. Animal health, Animal are international. area in this challenges the of Many is an important resistance, disease specific and general including Technology European the of document vision 2025 part the of which to Reproduction and Breeding Animal Sustainable on Platform is a signatory. BBSRC aimed research for initiative a £4.5M launched we 2006 In January will complement This flu. avian of biology basic the understanding at a diverse will cover and Council, Research Medical the by funding new influenza of virology the epidemiology, including aspects of range development. vaccine and interactions host-pathogen infection, Animal health and welfare is not only intrinsically valuable, it also it valuable, intrinsically only is not welfare and health Animal Multidisciplinary research on a small wading bird, the Kentish the bird, wading a small on research Multidisciplinary that care of levels agreed the into insights is giving Plover, most Unlike young. their to provide parents female and male care parental more provides Plover Kentish male the birds, between project A collaborative female. the than field and Bristol of University the at modellers mathematical nest that shown has Bath of University the at researchers behaviour the changes cooling, egg specifically temperature, This mate. its by a response to leading parent brooding the of interactions parental understanding for implications has work animals. in other Animal health and welfare welfare and health Animal In October 2005 we reported the outcomes of the consultative review consultative the of outcomes the reported we 2005 In October a in which genomics, animal in farm research future for priorities of and FRS sought CBE Tickle Cheryll Professor by chaired panel and policy community, scientific the from input considered was health Animal NGOs. and welfarists animal end-users, commercial factors on variation genetic of effect the with priority, top the clearly area. research an important as viewed also welfare animal affecting has direct impacts on human health and on important social issues, social important on and health human on impacts direct has it and in research; animals of use the surrounding those including We industries. related and livestock the on economically impacts with research collaborative for support increased announced have economic scientific, are strong 22). There (page area in this industry animal complementary together bringing for grounds ethical and that in ensuring and expertise of centres in world-class research and health practical to through feed science in basic advances Delivery 2005-08 in our announcement the Following issues. welfare have we welfare, and health £6M in animal will invest we that Plan on focus will that in 2006 initiative a new for planning begun in the animals farmed of diseases infectious endemic into research are We parasites. external and internal by caused those UK, including and health animal on research institute-based for support increasing £0.5M to over of support announced also have 8). We (page welfare Reduction and Refinement Replacement, the for Centre National the 2007-08. to period the over in Research, Animals of 14 BBSRC Annual Report & Accounts 2005-06: Management Commentary International science neuroscience. participated inaUK-Japan symposium on technology and metabolic network modelling. We collaborative approaches infermentation and depression; and the development of regulation of systems that underlie stress, anxiety We awarded four JPAs for research including the Chinese Ministry of Science and Technology. contributing to high-level negotiations with the researchers inChina on the biology of avian flu, and scientists at the Institute for Animal Health and BBSRC isalso supporting collaboration between improved diet and health; and biomaterials for tissue engineering. cultured mammalian cells; harnessing wheat genetic diversity for products intraditional medicines; improving stress tolerance in awarded seven CPAs, for topics including: the effectiveness of natural Partnership Awards (CPAs and JPAs respectively). This year we scheme that builds on the success of our China and Japan India inNovember 2005, we arelaunching apartnership award the UKscience base. For example, following our high-level mission to interactions with priority international partners, to further strengthen A healthy UKscience base We support arange of activities to develop and sustain and disease resistance. collaborations inpig genomics and genetics to improve muscle growth and the Huazhong Agricultural University Veterinary School to develop with Professor Yuhong Suand colleagues at the Jinzhou Medical College Dr Kin-Chow Chang (left) at the University of Glasgow willbe working helps advance agriculture, food production and healthcare in illustrates how our research A recent BBSRC publication developing countries. countries. developing guide to the more complex genomes ( preparation for FP7. which isintended to help develop further collaborative working in Memorandum of Understanding between the three organisations, with INRA and Wageningen University Research, BBSRC has signed a European countries. Reflecting our increased level of collaboration (ERASysbio), involving research funding organisations in14 BBSRC has also joined anew ERA-Net inSystems Biology Innes Centre with representatives of the eleven partner countries. 2006, and organised aninternational workshop held at the John Plant Genomics which announced acall for proposals inFebruary contributed to the European Research Area Network (ERA-Net) in the EU’s forthcoming Framework Programme 7(FP7).BBSRC European research. We have advised on the structure and content of immediate relevance -rice sustains Centre were of aninternational part team that mapped the rice genome Nature has already helped inidentifying BBSRC scientists continue to make a major contribution to contribution major a make to continue scientists BBSRC genome isexpected to provide a over half the world’s people -the agronomic traits. from Apart its Researchers at the John Innes of wheat, sorghum and maize. genes that underlie important (2005) 436, 793-800). This ecosystems to stabilise soils and landscape. researchers inthe Sudan to develop plant Environmental Research to work with scientists at the Institute of Grassland and for support included have These Scheme. through our International Scientific Interchange We have awarded 37 grants totalling £85.2k Insect Physiology and Ecology inNairobi, Kenya. Governing Council of the International Centre of Rothamsted Research has been appointed to the working. Professor John Pickett CBE FRSof development agenda, and look forward to closer supported research can best contribute to the International Development how BBSRC- We have explored with the Department for Department the with explored have We 15 BBSRC Annual Report & Accounts 2005-06: Management Commentary A healthy UK science base UK science A healthy training environment. environment. training continuing to provide Vacation Bursaries that enable that Bursaries Vacation provide to continuing Following a successful pilot scheme in 2004, BBSRC is BBSRC in 2004, scheme pilot a successful Following line with BBSRC Quota PhD studentships, ensuring that ensuring PhD studentships, Quota BBSRC with line undergraduates can work in departments with a strong with in departments work can undergraduates awards for 'Vacation Bursaries in Mathematical Biology'. in Mathematical Bursaries 'Vacation for awards undergraduates to undertake research. We are currently We research. undertake to undergraduates Bursaries are awarded to university departments, including departments, university to are awarded Bursaries supporting 80 bursaries p.a. and have announced a further 20 a further announced have and p.a. 80 bursaries supporting veterinary schools, and BBSRC-sponsored institutes, largely in largely institutes, BBSRC-sponsored and schools, veterinary The first of three annual courses on practical proteomics was held at held was proteomics practical on courses annual three first of The scientists BBSRC-supported enables course The York. of University the about hear and technologies proteomic of experience hands-on gain to It is supported applications. their and developments technical latest the and initiative, Training e-Science and Proteomics the through BBSRC by Leeds, York, of Universities the from tutors of expertise the upon draws from scientists 20 Over Ltd. Dynamics Nonlinear and Cambridge, and participated. institutes BBSRC-sponsored and departments university For the third consecutive year, BBSRC has part-sponsored a part-sponsored has BBSRC year, consecutive third the For BBSRC’s ten year vision for science and innovation in the sponsored in the innovation and science for vision year ten BBSRC’s and staff train and will support we how 8) describes (page institutes BBSRC’s courses, training institute-led to In addition students. course training its increased has team Development and Training 61%. by provision on working researchers for school summer residential practical Centre Sheffield of University the at cells stems embryonic human Biology. Cell Stem for .

SET for Success (2002) Management and leadership for culture change. culture for leadership and Management An holistic approach to performance management. performance to approach An holistic development. and learning proactive Employee-led, In November 2005, 130 postgraduate students and postdoctoral and students postgraduate 130 2005, In November Researchers” of Generation “Next second BBSRC’s attended researchers meet to scientists career early for an opportunity This provided meeting. to how including issues, development career of a range discuss and between moving and opportunities training funding, grant obtain research. industry-based and academic Training and career development career and Training The RCUK Research Careers and Diversity Unit was established in established was Unit Diversity and Careers RCUK Research The implications the on Councils Research the for leads and 2005 April Code the and Researchers for Charter EU the of implementation and in September launched was that Recruitment their for Conduct of and Careers Research a cross-Council by is supported Unit The 2005. member. is an active BBSRC the which of Group, Diversity BBSRC’s Human Resources Strategy Board held its first meeting in meeting first its held Board Strategy Resources Human BBSRC’s priorities: strategic as forward is taking and identified It 2005. April BBSRC contributes to several UK-wide deliberations on career on deliberations UK-wide several to contributes BBSRC the RCUK on represents Goodfellow Julia Professor development. of development the led has and Forum Funders Base Research OSI’s current the analysing and paths career research promoting projects Roberts’ the of publication the following researchers, for situation Review, Our new Human Resources Strategy will support staff and students in students and staff will support Strategy Resources Human new Our research wider the appropriate, where and, institutes sponsored our developing and recruiting for vision our deliver to aims It community. UK’s the develop and will maintain who individuals skilled highly promoting includes: It base. innovation and science world-class appropriate providing performance, managing HR practice, good manage to individuals allow that opportunities flexible and rewards development. own their 16 BBSRC Annual Report & Accounts 2005-06: Management Commentary Studentships and Fellowships 2005) and willincrease this to £12.3k from October 2006. We increased the standard BBSRC PhDstipend to £12k (from October collection. data experimental with coupled systems, biological of components the focus on mathematical, statistical and computational modelling of will complement Centre funding (page 10). The DTC at Warwick will University of Warwick 9.Inthe cases of Manchester and Oxford these follows: University of Manchester 12; University of Oxford 9; BBSRC issupporting atotal of 30studentships at the Centres as Centres (DTCs) inSystems Biology, at atotal cost of over £11M. In partnership with we arefunding EPSRC three Doctoral Training and Bioinformatics. 12); Selective Chemical Intervention inBiological Systems (page 6); integrative mammalian physiology (page 22);crop science (page Studentships) that willcommence inOctober 2006. These arein Studentships this year, (these replace our Strategic Research UK research capacity. We awarded atotal of 40 Targeted Priority research, including those where we areinvesting inorder to enhance to provide the future supply of researchers inpriority areas of We have introduced greater targeting so that more studentships help first destinations. and transferable skillstraining; PhDsubmission rates and students’ supervisors; research facilities and research environment; generic institute’s, training strategy, including the selection and training of competition tests awide range of aspects of adepartment’s, or BBSRC’s commitment to the peer-review of training quality. The through BBSRC’s Studentships and Fellowships Panel, as of part The Quota Competition for DTGs was assessed inDecember 2005 and MRC. EPSRC DTGs with the two other Research Councils that deploy them, scientific needs. We have harmonised terms and conditions for previously, enabling them to optimise their training profile to meet provides research supervisors with much greater flexibility than use monies as part-funding injoint-supported studentships. This to allocate studentships for either three or four years’ duration and to the basis of four-year studentships; but departments have discretion awarded as Doctoral Training Grants (DTGs). Funding iscalculated on all of our quota studentships, starting inOctober 2006, have been flexibility inthe training of postgraduate students. For the first time, A healthy UKscience base We have introduced several changes aimed at providing greater oa 2050 111 194 927 272 151 395 *Current as at 31 March 2006 Total Masters Other Research Other CASE Industrial CASE Research DTG CASE DTG yeNumber Type disease inwinter oilseed rape. postgraduate student inplant sciences in2005-06: Investigating fungal Nottingham 2006 Edward Cocking Prize for the most outstanding Maria Eckert of Rothamsted Research was awarded the University of All studentships* Education and training insupport of commercial exploitation of research outcomes aredescribed on page 26. 17 BBSRC Annual Report & Accounts 2005-06: Management Commentary as at as at 31.03.06 31.03.06 - by postgraduate funding postgraduate - by A healthy UK science base UK science A healthy Funding (£M)Funding graduates Fellowships University Postgraduate Post- No. of No. Top twenty five Universities Universities five twenty Top from BBSRC 10 Birmingham11 Sheffield12 Warwick13 Bristol 1.2614 Tyne upon Newcastle 15 Glasgow 1.24 0.99 7716 Dundee17 1.12 Anglia East 78 55 1.0418 1 Leicester19 Aberdeen 79 0.9120 69 2 Liverpool 0.89 0.8721 Reading 49 1 22 Southampton 0.73 5223 79 Bath 0.69 1 24 Sussex 0.67 42 25 2 London College Kings 0.57 1 42 0.58 37 0.45 38 44 0.56 0.53 1 28 33 33 1 Ntiga .11121 2 1.91 Cambridge22.95 Manchester 3 Leeds4Nottingham 1895 3.33 Imperial College London6 Oxford 4 1.677York 1658 1.97 London College University 859 90 1.52 9 Edinburgh 1.62 105 3 1.66 1 85 5 77 1.28 3 88 3 1 Starting in academic year in academic Starting 2002-03 2003-04 2004-05 1998-99 1999-00* 2000-01* 1999-2003 2000-04 2001-05 DTG studentships awarded in 2005-06 by scientific area scientific by in 2005-06 awarded studentships DTG Area Number Training first rate people first rate Training Genes & Developmental Biology (GDB) Biology & Developmental Genes (PMS) Sciences & Microbial Plant Total 74 95 546 Agri-food (AF)Agri-food (AS) Sciences Animal (BCB) Biology & Cell Biochemistry (BMS) Sciences Biomolecular (EBS) Systems & Biological Engineering Facilities and Equipment 159 31 87 59 39 2 First destination data of PhD students of data destination First (% of known destinations) known (% of Students qualifying from from qualifying Students (%) courses Masters PhD submitting Students 86 (%) 4 years within theses 84 96 80 97 73 industry or commerceGovernment/ public sectorother employmentOther Not employed 21Overseas*Collected by HESA 8 2 17 12 6 17 1 18 7 17 1 12 27 9 employment 39 training Further teaching)(excl. or teaching School 31 trainingteacher sector, Private 32 2 3 2 2 3 1 Permanent academic employment academic Fixed-term 1 5 3 18 BBSRC Annual Report & Accounts 2005-06: Management Commentary training and career development inthe wider bioscience community. summarising the many ways inwhich BBSRC seeks to support bulletin.html). We have also developed anew for the research community (www.bbsrc.ac.uk/funding/training/ up to date information on developments and training opportunities postgraduate training and career development issues, which provides BBSRC has launched amonthly electronic news bulletin on tenured academic positions. paths for researchers to move from short-term research contracts to launch of the scheme by OSI in2004. These awards provide career colleges across the UK,bringing the total number to 800since the awarded 400 Fellowships to researchers in73 universities and second round of RCUK-administered Academic Fellowships. The Panel Fellowship Strategy Panel chaired the assessment panel for the Professor Mary Bownes OBE, Chair of BBSRC’s Studentships and stem cells. These willbe made in2006. through the MRC-administered Career Development Fellowships in We have announced our intention to fund afurther two projects opportunities. attracting high calibre researchers and providing career development blood’ funding willstrengthen priority areas ininstitute science by allocated in2006-07, rising to £1.5M p.a. by 2008-09. This ‘new has announced anew Institute Fellowship scheme: £0.5Mwillbe Following the 2005 Institute Assessment Exercise (page 8)BBSRC Electronic Submissions (Je-S) system. applications were also received for the first time through the Joint 2004-05, which recommended anumber of changes. Fellowship outcomes of the Review of Fellowships that was undertaken in 2006-07. The Fellowship competition this year also reflected the awarded inthe 2005-06 competition and which willbe taken up in We arefunding fulleconomic costs for Fellowships that were in 2006, for training starting inOctober 2007. areas through atraining account system. The competition willbe held concluded that future awards should be made instrategic priority awarded inaquota competition every three years. The review We have reviewed our portfolio of Masters studentships which are A healthy UKscience base ‘People’ leaflet, Biological Sciences inBangalore, India in2005. an EMBO workshop at the National Centre for USA National Institute of Health, and organised Cellular Signalling, aninitiative funded by the invited to be amember of the Alliance for Institute Assessment Exercise. DrPadinjat was highest international standard during the 2005 animals. Thiswork was assessed as of the hormones and neurotransmitters inother understanding of the actions of anumber of melanogaster Drosophila the functional genomics of the fruit fly, at Babraham Institute, isleading research into Dr Raghu Padinjat, BBSRC David Phillips Fellow , to improve 19 BBSRC Annual Report & Accounts 2005-06: Management Commentary ce at 9). k. rs of ncy and ncy Professor Sir Michael Professor Emeritus FRS, Berridge Babraham the at Professor the awarded was Institute his for Prize Shaw 2005 cell on research pioneering signalling. Dr Giles Oldroyd, a BBSRC Oldroyd, Dr Giles the at Fellow Phillips David was Centre Innes John European 17 among under recognised scientists Investigator Young the European the of Programme Biology Molecular also was He Organisation. outstanding five of one to invited scientists British take part in ‘Celebrating Royal a joint Science’, British in event OSI Society/ 2006. Week Science National A healthy UK science base UK science A healthy Professor Ian Crute, Director of Rothamsted Research has been awarded been has Research Rothamsted of Director Crute, Ian Professor an made have who individuals recognises which Medal, BCPC the protection. crop to contribution outstanding BBSRC staff BBSRC 1,300 in 2001-02 and has decreased by 79% in four years. years. in four 79% by decreased has and in 2001-02 1,300 On 1 April 2006, 2,366 staff were employed on indefinite contracts in institutes sponsored by BBSRC and in the BBSRC Office. Office. BBSRC in the and BBSRC by sponsored in institutes contracts indefinite on employed were staff 2,366 2006, 1 April On the number and proportion of researchers on fixed-term contracts (often funded externally e.g. by Defra). This peaked at almost at peaked This Defra). by e.g. externally funded (often contracts fixed-term on researchers of proportion and number the small businesses; five engineering based businesses established by institute staff are based on the institute site at Wrest Par Wrest at site institute the on are based staff institute by established businesses based engineering five businesses; small staff, mainly scientists, held period appointments funded by BBSRC directly (179) or by industry and other external sources (16 sources external other and industry by or (179) directly BBSRC by funded appointments period held scientists, mainly staff, Of the indefinite staff 1,094 were in the science category, of which 93% were graduate or equivalent level. A further 348 membe 348 A further level. equivalent or graduate were 93% which of category, science in the were 1,094 staff indefinite the Of indicates that over 60% of scientific and technical staff are working in scientific posts. These include science-based consulta science-based include These posts. in scientific are working staff technical and scientific of 60% over that indicates Silsoe Research Institute closed on 31 March 2006. Over twenty scientific and technical staff moved to BBSRC-supported research BBSRC-supported to moved staff technical and scientific twenty Over 2006. March 31 on closed Institute Research Silsoe Women now occupy 20% of senior posts in BBSRC (Band 1 to Band 4). The comparable figure for 2004-05 was 15.7%. We are reducing We 15.7%. was 2004-05 for figure comparable The 4). Band 1 to (Band in BBSRC posts senior of 20% occupy now Women Rothamsted Research (biomathematics and soil science) and Royal Veterinary College (animal behaviour and welfare). Early eviden Early welfare). and behaviour (animal College Veterinary Royal and science) soil and (biomathematics Research Rothamsted The BBSRC's policy in relation to the employment of disabled of employment the to in relation policy BBSRC's The BBSRC received a Silver Award from Opportunity Now for Now Opportunity from Award a Silver received BBSRC In line with new legislation we are developing Action Plans for Plans Action are developing we legislation new with In line locally staff with communicate to practices of a range utilise We Disability, Race and Gender Equality Duties and, together with with together and, Duties Equality Gender and Race Disability, of use and gathering the are improving Councils, Research other data. diversity Union Trade with regularly meets management Senior nationally. and Consultative Negotiating Institute and in Central representatives that matters other and service of conditions discuss to Committees corporate and briefings circulars, Bulletins, operations. BBSRC on bear to in addition staff, with communicate to used are also publications individuals. to letters direct encouraging inclusiveness for women. We are further embedding are further We women. for inclusiveness encouraging practices; and policies of an audit through: diversity workplace to returners for Fellowships Jackson Daphne for support continued and disability on training surveys; national in participation science; awareness. transgenderism persons is, where practicable, to continue to employ employees who employees employ to continue to practicable, where is, persons of all members As with disabled. permanently or temporarily become development career needs, training their to is given full regard staff to given is also consideration fair and Full potential. promotional and account into taking are disabled, who applicants of recruitment the abilities. and aptitudes their 20 BBSRC Annual Report & Accounts 2005-06: Management Commentary for five more years with MRC. years and agreed to continue co-funding the National Stem Cell Bank renewed funding for ARKGenomics at Roslin Institute for three more We support anumber of national research facilities; and in2005 we funding streams: Tools and Resources Strategy Panel has identified three priority tools resources. We have made £23.2M available to support this. Our Contemporary bioscience depends increasingly on new research will support small or short-term pump-priming projects and facilitate collaborations. *Complementing the Initiative isour £3-4M Tools and Resources Development Fund that UK facilities and infrastructure A healthy UKscience base developed anew method for observing proteins at work inside living cells. means that the protein iscloser to its natural state and therefore ismore Fluorescence from labelled protein Unlike conventional approaches that tag proteins by attaching them to likely to interact normally with other molecules inthe cell. Funded by inserts atiny fluorescent label direct into the protein of interest. This BBSRC, Wellcome Trust, Royal Society and EU Marie Curie Fellowship. Bioinformatics and Biological Resources Fund. Tools and Resources Development Fund. (joint with EPSRC) Technology Development Research Initiative*. fluorescent proteins whose fate can be tracked, the new technique Cambridge and researchers at the CCLRC Central Laser facility has Collaborative research between bioscientists at the University of University the at bioscientists between research Collaborative Fluorescence from misincorporated label, unincorporated label and background of Sheffield. of Manchester; and imaging of 3Dengineered tissues at the University high brilliance X-ray generator with CCD detector at the University of for the study of protein trafficking and development at the John Innes Centre; astate-of-the facility art to measure the impact of environmental variation on plant disease health and microbiology at the Institute of Food Research; equipment analysis of diverse cell populations for novel applications indiet, microscopy at the Babraham Institute; equipment for sorting and near-membrane processes inliving cells using total internal reflection mass spectrometry facilities at the University of Aberdeen; imaging (£750k). Topics included: support for multicollector isotope radio (£5.1M) and eight projects within BBSRC-sponsored institutes Initiative in2005, supporting 40 projects within UKuniversities Research Equipment Initiative We awarded atotal of £5.8Munder the Research Equipment cells stimulated with histamine (Babraham Institute). Movement of Capri protein (green) to the plasma membrane inHeLa in vivo at the University of Leeds; a A healthy UK science base

e-Science Programme

Since 2002 we have awarded more than £23M in the Bioinformatics and e-Science Programme, funding 61 projects in 44 Examples of some of the different universities and institutes. For example, the joint e-Protein achievements of the first project between Imperial College London, University College five years of the UK e- 21 Science Programme have London and the European Bioinformatics been published by the Institute, in collaboration with Sun Research Councils. BBSRC Microsystems, aims to provide a structure- based annotation of all proteins in major sequenced genomes, pooling computational Annual Report and database resources at the three sites using Grid technology. With a system to manage this huge, combined computational power and a web- based 'front end' system now in place, a key &

achievement to date has been the annotation of Accounts 32,000 unique protein sequences in the human genome within one day, accessing 500 ‘nodes’ at University College London and Imperial College London. 2005-06: Management Commentary

In 2005 we allocated remaining funding to specific initiatives within the Bioinformatics and e-Science Programme, including the £1M e-Science Development Fund and a fund for pump-priming and scoping activities, for training in proteomics and e-science under which £286k has been allocated. (page 15).

BBSRC is continuing to support the European Molecular Biology Open Software Suite (EMBOSS), which provides bioinformatics and tools for the bioscience research community. We are continuing to support the European Bioinformatics Institute (page 4).

In October 2005, we held a workshop to review outputs from BBSRC’s Bioinformatics and e-Science Programme phases I and II. These included:

Developments towards an e-Science infrastructure for exploring pathogenicity determinants so that fungi which have the potential to cause disease may be readily distinguished from those that do not (University of Manchester).

A prototype model that will enable scientists to map genome information from different sources and across different species (Roslin Institute). 22 BBSRC Annual Report & Accounts 2005-06: Management Commentary Courtesy of Syngenta Technology Strategy and collaborative research with industry Enhancing exploitation of research outcomes science (page 12). welfare (page 13) and afurther £1.5M for IPAs inplant and crop earmarked afurther £1.5M for IPAs inthe area of animal health and 10% cash support to responsive mode grant awards. We have Partnership Awards increasing our support for collaborative research through research with industry to £8Mby 2007-08. Specifically, we are announced its intention to double grant support for collaborative has BBSRC bioscience. in base academic nation’s strong the fundamental scientific understanding. Such sectors rely heavily on commercial advantage arises directly from, and close to, advances in weeds that have become resistant to conventional herbicides. opportunity of novel targeted compounds capable of killing herbicide activity, and at the same time offers the industry the understanding of how molecular structure determines generation herbicides. The partnership advances development of new chemicals that have potential as new academics’ structural biology expertise with the company’s agrochemical company Syngenta issuccessfully combining the An IPA between scientists at the University of Sheffield and the In the successful UKpharmaceutical and biotech sectors, (University of Sheffield/Syngenta). dehydratase), which binds its substrate between two manganese ions The active site of anovel herbicide target (imidazoleglycerol phosphate (IPAs), inwhich industrial partners contribute Industrial a call on Bioscience for Industry. biocompatible and biomimetic materials. We arealso participating in This will cover areas such as tissue engineering, drug delivery and in Regenerative Medicine, under the National Technology Programme. place to support the needs of UKindustry. Specifically, within a We arepartnering and MRC the EPSRC, DTI inacall for proposals Scottish Funding Council and industrial companies that totals manufacture of complex biopharmaceuticals. The Club isalso Industry, Higher Education Funding Council of England, MRC, up to £12.3M, we arefunding four major projects to improve We have made progress on priority areas of our understanding at the whole organism level of complexity of stakeholders to help ensure that high quality research isin systems inmammalian physiology. We have also invested innovative research including that needed for the efficient Strategy funding partnership with the Department of Trade and being supported (£3M)and by aconsortium EPSRC of £6M to launch aBioprocessing Club that willsupport industrial companies (£1M).It isbeing managed by – through which we work with industry and other BioProcessUK with funding from DTI. Technology 23 BBSRC Annual Report & Accounts 2005-06: Management Commentary Enhancing exploitation of research outcomes research of exploitation Enhancing Collaborative research between Entercel Ltd and scientists at scientists and Ltd Entercel between research Collaborative BBSRC is one of the sponsors and partners of a new Sensors a new of partners and sponsors the of is one BBSRC The biopharmaceutical drug market is projected to generate over generate to is projected market drug biopharmaceutical The production lower-cost for technology A new 2010. by in sales $50billion and Institute, Roslin the at pioneered is being drugs protein many of animal in transgenic lead world long-standing institute’s the on builds Dr Helen plc, BioMedica Oxford and Inc Viragen with Working science. ‘humanised’ a functional in producing succeeded has team Sang’s hens. transgenic of eggs of white in the an interferon and antibody, Programme Chairman Melanie Lee, Executive Vice President R&D UCB President Vice Executive Lee, Melanie Chairman Programme Applied the of outcomes the on meeting a packed at SA, speaking The 2005. in April Society Royal the at programme LINK Genomics in a resulted DTI, the and MRC BBSRC, by funded was which programme, of development the for advances technological and scientific of range cancer, including conditions for diagnostics and therapies new for drugs as well as injuries cord spinal and disease Alzheimer’s the on presentation MRSA. by A further caused those as such infections 2005. in November Parliament of Houses in the made was programme Knowledge Transfer Network (one of a series of networks instigated networks of a series of (one Network Transfer Knowledge UK). It in the sectors technology in key innovation stimulate to DTI by in developments new to access from benefit to industry help to aims R&D. instrumentation advanced Rothamsted Research is helping to develop an enhancer technology an enhancer develop to is helping Research Rothamsted triazole important commercially of effectiveness the restore to fungi control and levels application reduce aim is to The fungicides. the that suggest findings Preliminary resistance. are developing that 32-fold. to up by levels infection reduce could technology new projects, in which projects, LINK BBSRC provides around £3M p.a. to enable academic and academic enable to £3M p.a. around provides BBSRC Researchers at the University of Bristol have successfully converted successfully have Bristol of University the at Researchers into patients osteoarthritis of marrow bone the from cells stem adult have They laboratory. in the them cultured and cells cartilage human cartilage of pieces into cells new the grow to a technique developed also cartilage pioneering to lead could advance this that It is hoped tissue. BBSRC by funded was research The a decade. within surgery transplant Group Nephew and Smith with in partnership grant a LINK through business. technology medical a global Research, With support under the Analytical Biotechnology LINK programme, LINK Biotechnology Analytical the under support With Newcastle of University the at scientists in 2005, finished which diagnostics antibody-based technology advanced several developed and limitations previous overcome These molecules. small for for screening, point-of-need for opportunities new provide and industrial in patient, contamination pesticide for example environmental samples. industry provides 50% of the funding. Currently we support research support we Currently funding. the of 50% provides industry and yield the affecting mechanisms genetic identifying includes that Research Crop Scottish (with barley of resistance disease and pest Affairs Rural and Environment Executive Scottish Institute, Farm New Dalgety/Secobra, CPB Twyfords, Advanta, Department, International, Research Brewing Weibull, Svalof RAGT/PBI, Crops, as well as Limited) Evaluation Crop HGCA, MRS, COORS, MAGB, SWRI, diseases enteric to responses immune innate for markers genetic that chickens for selection help could that pathogens food-borne and Roslin Health, Animal for (Institute infection to resistant are more Aviagen companies breeding poultry leading world’s the and Institute co-sponsor to agreed have We Defra). with funded Cobb-Vantress, and Defra. with Materials Renewable on programme £5M LINK a new industrial groups to work together through through together work to groups industrial 24 BBSRC Annual Report & Accounts 2005-06: Management Commentary Commercialisation of research looking forward to bringing them to the clinic," DrSylvie Ducki. project. We have now selected several candidate drugs and are BBSRC. This has allowed us to explore the commercial aspects of this "We aredelighted to have been awarded the Follow-On Fund by Oxford to develop more effective enzymes for industry. starving cancer tumours; and for researchers at the University of to explore inhibition of cell scaffolding assembly as ameans of £1M. These include support for scientists at the University of Salford business development. In2005, we made 17 BBSRC Awards, totalling ideas arising from their research, and to secure opportunities for of potential commercial the demonstrate to scientists enables which fourth round of support, totalling £1.4M, for the Enhancing exploitation of research outcomes to tumours become blocked, effectively starving the tumour to death. Targeting tubulin with aview to inhibiting its assembly so that blood vessels her BBSRC-sponsored research at aparliamentary event in2005. Minister Lord Sainsbury (centre) and Brian Iddon MPafter presenting Sylvie Ducki of the University of Salford, photographed with Science BBSRC, inpartnership with and has NERC, EPSRC launched the Follow-On Fund Follow-On , full commercial version ready for licensing. where he can use it for contract service work and then to develop a develop the prototype. He aims firstly to develop the Model to astage prototype. He has since been awarded anEnterprise Fellowship to by aFollow-on Fund award that enabled himto validate hisworking knowledge and expertise inhuman gutbehaviour, he was supported medicines within the human gut. To develop the ‘Model Gut’ from his pharmaceutical sectors to predict digestion of real foods and computer-controlled model that could be used by the food and Dr Martin Wickham of the Institute of Food Research isdeveloping a The scheme inpartnership isrun with the Royal Society of Edinburgh to progress their research towards commercialisation. provide asalary for one year and business training for scientists We have awarded the firstBBSRC Enterprise Fellowships. These Dr Martin Wickham Dr Mark Eccleston, University of Cambridge Dr Ian Shadforth, Cranfield University Transforming proteomic data into commercial knowledge Responsive biopolymers for delivering Dr Riccardo Bennett-Lovsey, Imperial College London discovery drug Logic-based Dr Wickham was also awarded support under the Follow-On Fund Dr Martin Wickham, Institute of Food Research A computer-controlled model to predict gutfunction innovative diagnostics and therapeutics 25 BBSRC Annual Report & Accounts 2005-06: Management Commentary business is achieving full tenancy. full tenancy. is achieving business Enhancing exploitation of research outcomes research of exploitation Enhancing “Biotechnology Investment Forum” in which early stage early in which Forum” Investment “Biotechnology business arm of the Babraham Institute, hosted its first its hosted Institute, Babraham the of arm business further investment and identifying new opportunities for opportunities new identifying and investment further was presented to investor groups, with a view to attracting to a view with groups, investor to presented was In February 2006, Babraham Bioscience Technologies – the Technologies Bioscience 2006, Babraham In February biotechnology from eighteen new businesses across the UK the across businesses new eighteen from biotechnology scientific and business expertise on the Babraham Research Babraham the on expertise business and scientific Following the Institute Assessment Exercise (page 8), BBSRC has 8), BBSRC (page Exercise Assessment Institute the Following Government’s the £5M under over won KT activities Bioscience Campus to aid the translation of ideas into commercial reality. commercial into ideas of translation the aid to Campus The Babraham BioConcepts facility for translating science into science translating for facility BioConcepts Babraham The The latest round of the RCUK Business Plan Competition was launched in launched was Competition Plan Business RCUK the of round latest The a significant which of applications, 130 It attracted 2005. November number were bioscience-based. announced that it will increase support for Knowledge Transfer Transfer Knowledge for support will increase it that announced on build to them enable to £1M p.a. by institutes at (KT) activities KT to approach portfolio their strengthen to and work existing their innovation. and one was awards the Among Fund. Exploitation Research Sector Public innovation manages which Ltd, Bioscience Plant £2M to almost of JIC and IGER, (IFR, institutes BBSRC-sponsored four across activities £1M was Almost shareholder. is a major BBSRC in which RRES) and also and Institute Roslin the by is led which Genecom, to awarded Moredun (and Health Animal for Institute the at research covers Institute). Research in Ciz1 Ciz1 2003-04 2004-05 2005-06 (BBSRC-sponsored institutes) A mixture of BBSRC core support for the Bloomsbury Structural Biology Structural Bloomsbury the for support core BBSRC A mixture of (ExGen) Genomics Exploiting our under a grant 1990s, late in the Centre ExGen Exploiting our through support and training and initiative, company spin-out develop and establish to helped has programme structure protein novel around is based company The Ltd. Domainex Research Its sector. pharmaceutical the for important technology Network Biotechnology London 2005 the won Savva, Dr Renos Director, award. Year the of Entrepreneur Young gene. BBSRC supports a PhD studentship to explore the role of of role the explore to a PhD studentship supports BBSRC gene. Pulling together several types of research, supported through a range of a range through supported research, of types several together Pulling BBSRC transfer. knowledge successful of a feature is often mechanisms Coverley’s in Dr Dawn research supporting funders several of is one (centre) Dr Coverley York. of University the at here) (pictured laboratory by supported Fellows Enterprise Yorkshire Bioscience thirty of is one Cizzle R&D company, own her is launching She Forward. Yorkshire the on based drugs cancer novel develop to Ltd, Biotechnology DNA replication. (Courtesy of Simon and Simon Photography) Simon and Simon of (Courtesy replication. DNA Transferring knowledge knowledge Transferring Spin-out companies trading companies Spin-out co- publications Refereed 13 industry with authored 15 80 16 69 65 Industrial income (£k) income Industrial awardedPatents 13,351 licensing Commercial agreements 11,261 intellectual from Income (£k)property 8,829 17 13 53 818 19 56 443 37 415 Financial figures are subject to audit within the sponsored institutes institutes sponsored the within audit to are subject figures Financial 26 BBSRC Annual Report & Accounts 2005-06: Management Commentary Education and training sixteen major companies, including food manufacturers and retailers. Predictive Microbiology for the Food Industry, attracted support from recently to the Institute of Food Research, for atraining module on prerequisite for BBSRC support. For example, acontract awarded intention to increase support for modular training by 40% by 2007-08. and best practice indelivering the courses. We have announced our In February 2006 we convened asuccessful event on sharing experience courses. BBSRC supported ten courses in2005-06, at acost of £298k. specialist knowledge up to date through flexible, industry-relevant graduates who have entered industry can keep their technical and exchanges of researchers on: stimulating longer-term partnerships. The first awards willsupport reciprocal access to facilities, expertise and knowledge, with aview to the science base and industry. This scheme isdesigned to increase support for sixshort-term exchanges of skilled individuals between on completion of their PhD. over 20% of BBSRC-funded postgraduates move directly into industry skilled individuals needed to maintain UKcompetitiveness. Already, to ensure that the specialist training we support provides the highly careers inscience-based companies. We work closely with industry companies, to commercialise their own research and equip them for technical skillsthat willhelp them to develop productive linkswith students and established researchers develop the business and Enhancing exploitation of research outcomes BBSRC supports avariety of mechanisms to help research (University of Warwick and Farfield Sensors). (University of Southampton and Microsoft) (University of Bristol and Advanta Seeds) (page 12) (Imperial College London and AstraZeneca) Strong industry demand and commitment to training isa We have launched apilot Our Technology for prion diagnostics methodologies marker Molecular Computer modelling of biological systems AstraZeneca) and Leicester of (University activity enzyme Heme State-of-the-art statistical analysis of large data sets Cell signalling (Babraham Institute and UCB Pharma) Modular Training for Industry Industry Interchange Programme programme helps ensure that with already aninternational shortage of appropriately trained personnel. tool for drug development inthe pharmaceutical sector, and there is supported by BBSRC. PET technology isanincreasingly important joint initiative between Imperial College London and GlaxoSmithKline, imaging of many different biological molecules inliving tissues -isa Emission Tomography (PET) –anew tool for simultaneous, real-time What isbelieved to be the UK’s only training module on Positron adaptation to the environment (Courtesy of GSK) the living human brain, which iscritical to memory and PET images showing the distribution of 5-HT4 receptor in record intraining provision. PartnershipCASE Awards with companies that have astrong track Awards and 272 Industrial Awards, CASE of which 204 areIndustrial an Industrial studentship. CASE BBSRC currently supports 345 CASE Syngenta (page 22)issupported by complementary work through partnerships. For example, the University of Sheffield IPA work with level. Insome cases these add value to other academic-industry mechanisms for industry-relevant training at the postgraduate CASE and IndustrialCASE Awards CASE with Pfizer. of white blood cells in immune responses. Itissupported inpartnership the University of Bristol, where she isstudying aspects of the regulation biosciences. Her studentship isinthe Department of Biochemistry at Graduates for outstanding performance by afemale PhDstudent inthe 2005 Ruth Bowden Scholarship from the British Federation for Women BBSRC-supported Industrial student CASE Samantha Passey won the are well established 27 BBSRC Annual Report & Accounts 2005-06: Management Commentary Enhancing exploitation of research outcomes research of exploitation Enhancing BBSRC and the National the and BBSRC Winners of the 2005 competition were a team from the University of Glasgow of University the from a team were competition 2005 the of Winners chiral of production the around based was business hypothetical whose development. in drug use for acids amino Sir Keith O’Nions speaking at the at speaking O’Nions Sir Keith YES reception. Biotechnology Endowment for Science Technology Science for Endowment developed have (NESTA) Arts the and and piloted bioscience involvement Pioneers Creative in NESTA’s of types new design to individuals encourages which Programme, of Universities the from bioscientists early-career Four companies. from and Newcastle, and London College Imperial Edinburgh, residential two-week the on places won Research Rothamsted 2006. in January course training Biotechnology Young Biotechnology Scheme (Biotechnology YES) has provided business provided YES) has (Biotechnology Scheme Since its inception in 1995, the the 1995, in inception its Since A BBSRC CASE studentship at Warwick HRI, in partnership with the with in partnership HRI, Warwick at CASE studentship A BBSRC the for options is exploring Council, Development Horticulture is of which aphid, currant-lettuce the of control biological sector UK horticulture the to significance economic considerable methods. conventional by control to difficult is very and Biotechnology YES is organised jointly by BBSRC and the University of University the and BBSRC by jointly YES is organised Biotechnology is a It (UNIEI). Innovation and Enterprise for Institute Nottingham participating in which plans, business hypothetical for competition financiers lawyers, patent entrepreneurs, from training receive teams Research Cancer BIA, by is sponsored It representatives. industry and Lonza GlaxoSmithKline, Clarkson, Potter Eric DTI, Pharma, UK, Celtic Forward, Yorkshire and Syngenta, RAE, MRC, NERC, Nestle, Biologics, UNIEI. and BBSRC as well as Entrepreneurs scientists. postdoctoral and postgraduate 1000 over to skills training Research of General Director the welcome to delighted was BBSRC reception a celebratory at speaker guest as O’Nions Sir Keith Councils, and participants current together brought This 2005. in December are whom of 40% ‘alumni’, over past of representatives with trainers in working 12% a further with industry, private in working now roles. management property intellectual or transfer technology 28 BBSRC Annual Report & Accounts 2005-06: Management Commentary contributed to establishment of the media RCUK office. ScienceRCUK inSociety Unit, and with other Research Councils; and in Society Strategy, increased our collaborative working through the contributed to the development of the Research Councils UKScience people of allages to engage with modern bioscience. We have information about current research and research outcomes; enabling outreach and communication activities aimed at providing At the same time, we have maintained avaried programme of advice from the Bioscience for Society Strategy Panel. and application of bioscience research, following recommendations and responding to, issues of public interest and concern around the conduct We have also strengthened our procedures for monitoring, and keeping BBSRC aware and responsive to wider social issues. these new activities so that we can optimise their usefulness in Society Strategy Panel, we arelearning from, and building upon, the field of nanotechnology. With advice from the Bioscience for research, as well as contributions to national dialogue activities in around future directions of specific programmes of BBSRC-supported ventures inattitude studies, consultations and discussion meetings into BBSRC’s planning and decision-making. This has included new dialogue and consultation activities, and on embedding the outcomes Embedding our science insociety We have increased our emphasis on opinion gathering, public management and the general conduct of research inthese areas. Farthing. This willpromote models for good practice, governance, and Biomedical Sciences, which isbeing led by Professor Michael BBSRC isalso supporting the UKPanel for Research Integrity inHealth the US National Science Advisory Board on Biosecurity. for example, presented by invitation at the March 2006 meeting of joint statement has been positively received internationally and was, the riskof research being misused, for example inbioterrosim. The agreed policy changes that strengthen procedures for minimising Misuse Associated with Grant Funding Activities” that highlights developed and published ajoint statement “Managing Risks of In partnership with and MRC the Wellcome Trust, we have aigorsineacsil:20 2005 2004 Making our science accessible: ++ * includes two jointly with NERC oa col oriaos2 26 25 27 9 9 60* 12 5 26 46 13 7 Science communication courses (and awards) 36 Local schools coordinators 18 (through RCUK) 11 Research student placements inschools awards engagement Public 5 (awarded through RCUK) Grants for National Science Week Exhibitions publications Corporate Media releases includes participation in2university-led courses + out of atotal of 33 awards statements/stem.html /accountability/position_ www.bbsrc.ac.uk/society on stem cell research. statement position re-published our updated and We have reviewed, 0 -06 -05 ++ + 29 BBSRC Annual Report & Accounts 2005-06: Management Commentary The Biodiversity The exhibition at the National of Museum Cardiff Wales, cited was which in times several Top Times’ the listings. Museum Embedding our science in society science our Embedding For the first time, BBSRC supported an interactive display and display an interactive supported BBSRC time, first the For Clockwise from top left: DNA science at the Natural Eisteddfod of Wales; of Eisteddfod Natural the at science DNA left: top from Clockwise Lord Festival; Science International Edinburgh the at ageing of science between collaboration closer on meeting a BBSRC at speaking Winston and in science; engagement public on institutes BBSRC-sponsored meeting Commons of a House at discussions research genomics applied in November 2005 presentation at the National Eisteddfod of Wales. This featured the featured This Wales. of Eisteddfod National the at presentation of University the from scientists by presented was and DNA of biology of a range at presented also were displays BBSRC Bangor. Wales, and in Birmingham, Centre Science ThinkTank the including venues supported also We Festival. Science International Edinburgh the at Research Rothamsted and Centre Innes John the by presentations and growth plant of modelling computer on Show Flower Chelsea the companion planting for crop protection respectively. Awards for National Science Week Week Science National for Awards science to barriers on study Society Royal the for Support Centre Media Science the of activities for and communication, BA Perspectives BA postgraduates) by presentations (public AGM Education Science for Association the at Presentation Research Energy on Engagement Public Nuffield Science Bursary Scheme Bursary Science Nuffield laboratories) in research placements student (school Centres Learning in Science teachers for CPD BA CREST Awards BA projects) research (schools (scientist placements in schools) Researchers in Residence Researchers At the Royal Botanic Garden Edinburgh in May 2005, we launched we 2005, in May Edinburgh Garden Botanic Royal the At BBSRC supports and contributes to the following, which are which following, the to contributes and supports BBSRC Unit: in Society RCUK Science the through coordinated a major new touring exhibition on the science of Biodiversity, of science the on exhibition touring new a major has display interactive NERC. This with in collaboration produced venues other with Cardiff, and Newcastle Glasgow, toured since a focus provided has it locations the of some At 2006-07. for planned issues discuss can visitors which at meetings discussion public for direct. researchers with 30 BBSRC Annual Report & Accounts 2005-06: Management Commentary Opinion gathering and public dialogue (www.bbsrc.ac.uk/about/pub/reports). Over two-thirds of those research, with prevention of health problems as apriority scientist, DrGene Rowe, showed strong support for diet and health Food Research (IFR) and led by asteering group chaired by IFR social science. The study, which was supported jointly with the Institute of Diet and Health, one of BBSRC’s priority research areas infood to conduct anattitude study of people’s views about research into subject of widespread public debate. In2005, we commissioned MORI line consultation on priorities inbiodiversity research. provided anopportunity for participants to contribute to BBSRC’s on- alongside the BBSRC-NERC exhibition on biodiversity (page29), project. This willbe held inSwindon in2006. dialogue on nanotechnology as of the part DEMOS-led Nanodialogues continued to develop afocus group-based experiment inpublic In partnership with and EPSRC, the think-tank DEMOS, BBSRC has University College London. researchers innanoscience organised by the Cambridge IRC at to apublic engagement awareness and training day for young Panel, which willadvise on BBSRC’s response. BBSRC also contributed recommendations were considered by BBSRC’s Bioscience for Society represent abroad cross section of society. The Jury’s to together chosen twenty people brought jury the Newcastle, and Life Sciences (PEALS) Research Centre at the University of Nanotechnology at the University of Cambridge and the Policy, Ethics Sponsored by Greenpeace UK,The Guardian, The IRC in Citizens’ Jury on Nanotechnology, which took place inSummer 2005. Embedding our science insociety Issues about food safety, quality and manufacture areoften the A discussion meeting at the Glasgow Science Centre, held was organised by PEALS (photograph courtesy PEALS). Some of the participants of the Citizens’ Jury on Nanotechnology, which BBSRC supported, and contributed to the oversight panel of, the February 2006. The results were discussed at the BBSRC Open Meeting (page 2)In public funding of research (www.bbsrc.ac.uk/society/issues/open). explored public perceptions of the relationship between industry and commissioned by BBSRC to explore this issue further, Corr Willbourn motives for funding research and public interest. Inaseparate study concerns about apotential conflict of interest between industrial of diet and health research. The study highlighted some people’s surveyed thought they should have some influence on the direction Environmental Research were among those who participated. Museum of Wales inCardiff. Scientists from the Institute of Grassland and people to discuss issues surrounding biodiversity research at the National A public Café Scientifique, hosted by BBSRC and NERC, provided aforum for National Museum of Wales inCardiff. for people to discuss issues surrounding biodiversity research at the A public Café Scientifique, hosted by BBSRC and NERC, provided aforum 31 BBSRC Annual Report & Accounts 2005-06: Management Commentary science at the IGER North Wyke science fair. science Wyke North IGER the at science Young students getting to grips with practical with grips to getting students Young Embedding our science in society science our Embedding BBSRC supports the Nuffield Bursary scheme, and several and scheme, Bursary Nuffield the supports BBSRC sponsored-institutes provide placements for sixth formers to formers sixth for placements provide sponsored-institutes vacation. school summer the during work practical undertake 63 the of careers the follow to attempted has Centre Innes John The 2001. and 1992 between Centre the at bursaries held who students had 20 questionnaire, a follow-up to respondents 39 the Of 14 a further and degrees, higher or undergraduate undertaken careers. in science-based were Among the 33 awards for National Science Week 2006, funded by funded 2006, Week Science National for awards 33 the Among through administered and Councils Research other three and BBSRC BBSRC. by supported individuals to awarded were 13 RCUK Unit, the at Day a Science for Institute Babraham the to grants included These teachers; and students GCSE and A-Level 150 around for Institute the the at formers 30 sixth for discussions and science practical of a day a hands-on Leeds; of University the at Sciences Plant for Centre 700 for Aberystwyth Wales, of University the at event science fair a science and area; Ceredigion the across children school primary Environmental and Grassland of Institute the of site Wyke North the at students. school 800 primary for (IGER) Research Members of Baytree of Members Science Club have in part cells, studied a drama through production. Over 70 researchers participated in a workshop on Systems Biology, run Biology, Systems on in a workshop participated researchers 70 Over was speaker Keynote 2006. in March EPSRC and BBSRC by jointly Inc. Laboratories Science Computer Sony of Kitano Hiroaki Professor

In addition to supporting school science through programmes through science school supporting to In addition

coordinated by the RCUK Unit (page 29), BBSRC has supported a supported has BBSRC 29), (page RCUK Unit the by coordinated coordinators, local our through links schools-researchers of number activities through and institutes BBSRC-sponsored at work through National the and Awards Engagement Public our by supported to grant RCUK. A BBSRC through coordinated Grants Week Science work to them enabled has London College University at researchers an after-school provides that in Brixton Club Science Baytree the with minority ethnic girls from year-old 8-11 for course science helping centre community is a non-profit Baytree backgrounds. girls in the year-old 18 3 to and parents lone women, unemployed by supported nine of one was project This Lambeth. of Borough in 2005. Awards Engagement Public BBSRC Schools and young people young and Schools 32 BBSRC Annual Report & Accounts 2005-06: Management Commentary Financial and other information a whole to deliver £170M efficiency savings ayear in2007-08. and willcontribute to meeting the Research Councils’ overall target as programmes and reducing the percentage spent on administration; will be achieved by several activities including re-prioritising We areplanning for these savings to rise to £39.2M in 2007-08. This for 2006-07 is£22.2M. This willbe delivered through: increasing efficiency at our sponsored institutes. Our savings target co-funding of research with industrial and other partners, and by by reducing the proportion that we spend on administration, by more This year BBSRC delivered efficiency savings worth £4M. We did this Centre, which isdue to be inoperation by March 2009. contribution to the setting up of a cross-Council Shared Service These activities and anumber of others willbe asignificant Councils, and inaproject to harmonise Human Resources Services. Office system to provide asingle grants processing system for all BBSRC has taken aleading role indeveloping aNext Generation Back pensions. and The joint units that we host include: building services, internal audit Council projects to identify and deliver additional harmonisation. based Research Councils: and by contributing to anumber of cross- across the Swindon- that joint units several hosting provide services channelled into research funding. We do this on two fronts: by harmonisation and thus achieve further savings that can be BBSRC strongly supports the continuing moves to increase have enabled us to move from two to four grants rounds ayear. (resource and capital -including non-cash) received during the Efficiency Research Council harmonisation administration costs for 2005-06 were £9.3M. This represents Operational efficiencies from new procedures and workflows, Following the deduction of £1.5M programme costs, BBSRC’s and greater use of electronic communication and databases 2.78% (2.95% in2004-05), of the Science Budget Income Re-prioritisation of programmes, including training (£8.6M). including better use of capital Infrastructure (£10M). Proportional reduction of administration costs (£1.1M). Increased efficiency of our sponsored institutes, More co-funding (£2.5M). year, against anOSI target of 3.4% by 2007-08. the year 1April 2005 to 31 March 2006 was 16. Injuries, Diseases and Dangerous Occurrences Regulations 1995) in The number of accidents reportable under RIDDOR (Reporting of Government Commerce’s Gateway process isused. programmes such as the Pirbright Development, the Office of and Group and Institute Directors. Inaddition, for significant supported by Statements of Internal Control from the Chief Executive, annually by internal and external auditors. Our procedures are executive management of BBSRC and the BBSRC Audit Board, and business critical projects. These areregularly reviewed by the structure of operational riskregisters, longer term strategic risksand management and innovative approaches to issues. We use aformal in amanner that ensures aproper balance isstruck between prudent BBSRC utilises arange of techniques to ensure that riskismanaged from landfill rose from 55% to 62% during 2005. Swindon-based Research Councils, show that the percentage diverted elements of our policy. Figures for waste recycling on the site of the Energy efficiency and the minimising of waste areimportant require the same commitment from our sponsored institutes. environmental best practice in connection with our operations. We We have formalised and strengthened our commitment to promoting eotbeicdn aeoy2005-06 (defined as inRIDDOR 1995) Reportable incident category Environmental policy vrl oa 16 16 0 2 3 0 0 0 Overall total Cases of occupational disease Total accidents 0 1 Another kind of accident 0 Physically assaulted by aperson Injured by ananimal 0 Contact with electricity or electrical discharge Exposed to anexplosion agent physical 0 0 3 Exposed to fire/heat/extreme cold or other 2 0 Exposed to, or incontact with, aharmful substance 5 Drowned or asphyxiated Trapped by something collapsing Fell from aheight 0 Slipped, tripped or fell on the same level Injured while handling, lifting or carrying Hit something fixed or stationary Hit by amoving vehicle Hit by amoving, flying or falling object being machined Contact with moving machinery or material Health and safety Risk management 33 BBSRC Annual Report & Accounts 2005-06: Management Commentary Financial and other information other and Financial Council Creditor payment policy payment Creditor The Council determines BBSRC policies and strategies. BBSRC BBSRC strategies. and policies BBSRC determines Council The between and Executive Chief the Chairman, the comprises Council their for are appointed whom of half least at members, other 10-18 in research, of Users engineering. and in science qualification represented. are also industry, and Government The Council adheres to the Principles of the Prompt Payers’ Code, and Code, Payers’ Prompt the of Principles the to adheres Council The of terms agreed the with compliance ensure effort to every makes 30 within them pay to endeavours and invoices creditors’ of payment of 92% 2005-06 During services. or goods of receipt of days 30 days. within made were payments came 2002 Regulations Debts Commercial of Payment Late The irrespective all businesses, providing 2002 7 August on force into payment late the for interest statutory claim to right the with size, of the during received were claims such No debts. commercial of year. reporting pension account which is a stakeholder pension with an employer with pension is a stakeholder which account pension basis a pay-as-you-go on RCPS are funded The contribution. annual and contributions employee and employer through principally related and retirement provide schemes pension The Grant-in-aid. Service Civil Principal the to analogy by emoluments final on benefits the by RCPS are administered (PCSPS). The Scheme Pension within a unit Services, Superannuation Joint Councils' Research the contain and are published RCPS Accounts Separate BBSRC. relevant the under required information of disclosure further accounting standards. schemes, benefit defined multi-employer RCPS are unfunded As the and assets underlying the of share its identify to is unable BBSRC Research the of Accounts in the found be can Details liabilities. www.bbsrc.ac.uk/about/pub/stats/ at Scheme Pension Councils welcome.html. following years four every reviewed be are to contributions Employer Department Actuary’s Government the by valuation a full scheme 31 at as GAD by out carried was valuation full actuarial last The (GAD). are they as benefits reflects rate contribution The 2002. March the reflect and incurred, are actually costs the when not accrued, past of scheme. experience the Revenue Grant-in-aid rose by £45.1M to £320.6M, financing financing £320.6M, to £45.1M by rose Grant-in-aid Revenue £30.8M to of grants capital and in research an increase and awards £5.5M in training of an increase and £264.9M £39.1M. to fellowships Revenue Grant-in-aid of £365.8M is confirmed for 2006-07. for is confirmed £365.8M of Grant-in-aid Revenue The Operating Surplus for the year was £6.5M, resulting in resulting £6.5M, was year the for Surplus Operating The to £13.5M of forward carried Reserve in General an increase £212.6M. £8M to by increased funds Government £15.6M. A downwards revaluation of dwellings at institutes institutes at dwellings of revaluation A downwards the of value the on £5.6M of a decrease to contributed base. assets fixed Council’s £1.1M, was 2005-06 for charge impairment total The in investments. in value £0.5M fall a including An increase in staff numbers and the employer’s pension pension employer’s the and numbers in staff An increase an and £1.6M of costs in staff a rise to led rate contribution BBSRC-sponsored to grants in core increase associated institutes. Forward commitment on approved research grants rose by by rose grants research approved on commitment Forward IAH Pirbright of redevelopment major The £387.7M. to £45.8M commitment. in capital increase a £27.5M to contributed The majority of the cash balance of £6M at 31 March 2006 2006 March 31 £6M at of balance cash the of majority The 2006. April in transactions property finance to held was As a result of allocations from the Spending Review 2004, 2004, Review Spending the from allocations of As a result Developments since 31 March 2006 March 31 since Developments Financial highlights Financial Pensions The BBSRC has responsibility for the Research Councils' Pension Councils' Research the for responsibility has BBSRC The is the BBSRC the of Executive Chief (RCPS) the and Schemes the of Employees schemes. pension the for Officer Accounting a partnership RCPS open or the join either to are eligible Council There have been no material events since the end of the financial the of end the since events material no been have There statements. financial these on impact which year 34 BBSRC Annual Report & Accounts 2005-06: Management Commentary the Council's Accounts. Councils’ Internal Audit Service, external audit reports and to review corporate governance, internal control reports from the Research meets three times ayear to monitor standards of riskmanagement, the exercise of independent judgement as board members. The Board relationship that, inthe opinion of the Council, would interfere with Council, being members independent of management and free of any three non-executive Committee members areappointed by the The Council has anAudit Board of which the Chairman and at least www.bbsrc.ac.uk/about/gov/ interest for Council, Boards and Committees can be found at Page 60 contains details of related party transactions. Registers of in BBSRC Swindon Office. standing and experience. The Clerk to the Council isasenior official Chairman, Council and the BBSRC Executive, isof anappropriate Council, which provides anadministrative interface between the The Council isalso expected to ensure that the position of Clerk to Estates &Equipment, Human Resources, Remuneration and Strategy. The sixareas dealt with by the Boards areAppointments, Audit, directed by Council. work of their respective Boards and to take forward specific tasks as it, and the Chairs of the Boards arerequired to report regularly on the The Council approves the membership of the sixBoards that report to conflicts of interests and general conduct. Industry. They arerequired to abide by aCode of Practice that covers All Members areappointed by the Secretary of State for Trade and Financial and other information Audit BoardAudit Chief Executive and Accounting Officer Professor Julia Goodfellow CBE the BBSRC's auditors areaware of that information. herself aware of any relevant audit information and to establish that make to taken have to ought she that steps the all taken has Officer of which the BBSRC's auditors areunaware, and the Accounting the Accounting Officer isaware, there isno relevant audit information audit work was performed by the Auditors during the year. Inso far as Technology Act 1965. The audit fee for the year was £44,000. No non- General inaccordance with Section 2(2)of the Science and The Accounts of BBSRC areaudited by the Comptroller and Auditor Auditors Date: 3July 2006 35 BBSRC Annual Report & Accounts 2005-06: Management Commentary PANEL MEMBERSHIP PANEL Panel Bioscience Industry for (Chair) Skingle Dr Malcolm GlaxoSmithKline Birch Dr John Lonza Coggins John Professor Glasgow of University Dennis Colin Professor Research Food Chorleywood and Campden Association Dyer Dr Richard Federation Biosciences Gillham Dr David Syngenta Strategy Board Strategy (Chair) CBE Goodfellow Julia Professor Executive Chief BBSRC OBE Professor Bownes Mary and Studentships Chair, Panel Strategy Fellowships Crute Ian Professor Independent Dart CBE Dr Ed Independent FRS Dell Anne Professor Panel Strategy Resources and Tools Chair, Fitzpatrick Julie Professor Independent Gilligan Chris Professor Member Council FRS Keverne Barry Professor Panel Strategy Organism Healthy Chair, Reiss Michael Professor Revd Panel Strategy Society for Bioscience Chair, Rigby Peter Professor Biology Systems Integrative Chair, Panel Strategy Skingle Dr Malcolm Panel Strategy Industry for Bioscience Chair, Professor Jeff Waage Panel Strategy Agriculture Sustainable Chair, Professor Dame Nancy Rothwell FRS Rothwell Nancy Dame Professor Member Council Weir Dr Malcolm Member Council (membership as at 31 March 2006) March 31 at as (membership Remuneration Board Remuneration (Chair) Ringrose Dr Peter Chairman BBSRC FRS Delpy David Professor Member Council CBE Goodfellow Julia Professor Executive Chief BBSRC FRS CBE Tickle Cheryll Professor Member Council Human Resources Strategy Board Strategy Resources Human (Chair) CBE Goodfellow Julia Professor Executive Chief BBSRC (Chair) OBE Bownes Mary Professor and Students BBSRC Chair, Panel Strategy Fellowships Bright Simon Professor Member Council Gallyer Marilyn Ms London College University McKellar Quintin Professor Member Council CBE Pollock Chris Professor IGER Director, Institute FRS Read David Professor Board Research Rothamsted Chairman, Directors of Swinburne Mr Peter Resources Human of Director BBSRC Professor Sir John Beringer CBE Beringer Sir John Professor Centre Innes John Chairman, Council Governing Crute Ian Professor Research Rothamsted Director, FRS CBE Gull Keith Professor Independent Penman Dr Alistair Audit BBSRC Chair Member, Council Committee Smith Mr Andrew HEFCE Estates, of Head OBSERVERS Brown Nigel Professor Technology and Science of Director BBSRC Clark Mr Geoff of Estates Head BBSRC Mr Visscher Steve Director Executive BBSRC Boards, Panels and Committees Committees and Panels Boards, Professor Julia Goodfellow CBE (Chair) CBE Goodfellow Julia Professor Executive Chief BBSRC Estates and Equipment Board and Equipment Estates OBSERVER CBE Goodfellow Julia Professor Executive Chief BBSRC Audit Board Audit (Chair) Penman Dr Alistair Member Council FRS Delpy David Professor Member Council Professor Robert Freedman Member Council Samuel Mr Mike Independent Schroeder Peter Professor Independent Appointments Board Appointments (Chair) Freedman Robert Professor Member Council FRS CBE Pickett John Professor Institute Representative Williams Christine Professor Committee Agri-Food BBSRC Chair, Skingle Dr Malcolm of Chair and Member Board Strategy BBSRC Panel Strategy Industry for Bioscience Brown Nigel Professor Technology and Science of Director BBSRC Yarrow Dr Doug Science Corporate of Director BBSRC BOARD MEMBERSHIP BOARD Professor Julia Goodfellow CBE Goodfellow Julia Professor Executive Chief Brown Nigel Professor Technology and Science of Director Swinburne Mr Peter Resources Human of Director Mr Visscher Steve Director Executive Yarrow Dr Doug Science Corporate of Director BBSRC Senior Staff 36 BBSRC Annual Report & Accounts 2005-06: Management Commentary Nuffield Council on Bioethics Dr Sandy Thomas Independent Ms Vivienne Parry University of Bristol Professor Christine Nicol Genewatch UK Dr Sue Mayer Sheffield of University Professor Julian Kinderlerer DAH Associates Dr Brian Johnson Liverpool of University Professor Alan Irwin Universities Federation for Animal Welfare Dr Robert Hubrecht Babraham Bioscience Technologies Ltd Dr David Hardman King Charles ISchool, Kidderminster Dr Nigel Collins Cardiff University Chadwick Ruth Professor The Royal Society Dr David Boak Association for Science Education Bell Derek Dr University Metropolitan London Dr Louise Archer Institute of Education, University of London Revd Professor Michael Reiss (Chair) Panel for Society Bioscience Department of Trade and Industry Dr Rob Morgan OBSERVER Pfizer UK Dr Nick Shepperson Inpharmatica Dr John Overington Novacta Dr Fiona Marston Bionow Dr Linda Magee University of York Professor Peter Lillford Thelsford Farm Mr John Lampitt Isis Innovation Tom Hockaday Mr Department of Trade and Industry Mrs Sarah Haywood Boards, Panels and Committees Institute of Physics, Freiburg, Germany Dr Jens Timmer Wageningen University, The Netherlands Professor Willem Stiekema University of Oxford Professor Denis Noble Technical University of Denmark JensProfessor Nielsen University of Portsmouth Professor Ajit Narayanan UCB Group Dr Melanie Lee Oxford Brookes University Professor David Fell Medical Research Council Dr Greg Elgar John Innes Centre Professor Enrico Coen FRS Unilever Research Dr Mark Cobain University of Warwick Bugg Tim Professor AstraZeneca Dr Aileen Allsop The Institute of Cancer Research Professor Peter Rigby (Chair) Integrative &Systems Panel Biology Medical Research Council Dr Morven Robert Foods Standards Agency Dr Alison Tedstone OBSERVERS GlaxoSmithKline Dr John Tite Sheffield of University Professor Tim Skerry University of Nottingham Professor Kevin Shakesheff Babraham Institute Dr Wolf Reik University College London Professor Linda Partridge CBE FRS Tyne upon Newcastle of University Professor John Mathers Liverpool of University Professor Jane Hurst University of Glasgow Professor Julian Dow University of Reading Professor Dianne Berry University of Cambridge Professor Barry Keverne FRS(Chair) Healthy Organism Panel Sciences Research Council Engineering and Physical Dr Elizabeth Hylton OBSERVER Netherlands The Universiteit, Vrije Westerhoff Hans Professor Genesis Faraday Mr Chris Warkup University of East Anglia Professor BillSutherland Syngenta Dr Sarah Rees Environmental Research Institute of Grassland and Professor Chris Pollock CBE Aberdeen of University Professor Ken Killham Home-Grown Cereals Authority Professor Graham Jellis University of Warwick Dr Laura Green Veterinary Laboratories Agency Professor Steve Edwards University of Abertay Dundee Professor John Crawford Brightman Farms Dr David Brightman Biogemma UK Dr Tina Barsby Imperial College London Professor Jeff Waage (Chair) Sustainable Agriculture Panel University of Kent at Canterbury at Kent of University Mike Geeves Professor Hospital General Northern Dr Sheila Francis Royal Veterinary College Professor Jonathan Elliott Ltd Heptagen Dr Mark Edwards Liverpool of University Professor Clive Edwards Physiological Society Dr Mike Collis University of Surrey Dr Michael Carter John Innes Centre Professor Nick Brewin University of Edinburgh Professor Mary Bownes OBE (Chair) Studentships &Fellowships Panel 37 BBSRC Annual Report & Accounts 2005-06: Management Commentary Boards, Panels and Committees Committees and Panels Boards, and Rural Affairs Department Rural and Biochemistry and Cell BiologyBiochemistry Committee (Chair) Marshall Dr Fiona Cambridge of University Cosby Louise Professor Belfast University Queen’s Darlison Mark Professor University Trent Nottingham Ehrmann Michael Professor University Cardiff Emery Vincent Professor Medical College & University Free Royal London School Professor Rob Field Anglia East of University Flower Dr Darren Institute Jenner Gilbert David Professor Glasgow of University High Stephen Professor University of Manchester Karran Dr Eric Ltd Company and Elli Lilley MacFarlane Dr Wendy University of Newcastle upon Tyne Martin Cathy Professor Centre Innes John McPherson Professor Michael Leeds of University Dr Alex Morrow Dr Alex Food Environment, for Department Affairs Rural and Professor Glyn Humphreys Glyn Professor Birmingham of University Kacelnik Alex Professor Oxford of University O’Kane Dr Cahir Cambridge of University Loudon Andrew Professor University of Manchester McCauley Dr John Research Medical for Institute National Parker Dr Amanda University of Newcastle upon Tyne Riley Eleanor Professor London School of Hygiene Medicine & Tropical Sneddon Dr Lynne University of Liverpool OBSERVERS Ambrose Dr Nick Environment Executive Scottish Animal Sciences Committee Animal (Chair) Foster Russell Professor London College Imperial Altringham John Professor Leeds of University Barrett John Professor Aberystwyth Wales, of University Professor Dave Burt Institute Roslin Campbell Dr Bruce Nottingham of University Professor Mike Denham Plymouth of University Haig Dr David Institute Research Moredun Hazlerigg Dr David University of Aberdeen Heyes Professor Celia London College University Professor Keith Edwards Keith Professor Bristol of University Fairweather-Tait Sue Professor Research Food of Institute Frankel Gad Professor London College Imperial Gill Dr Pinder Commission & Livestock Meat Hirst Barry Professor University of Newcastle upon Tyne Ketley Julian Professor Leicester of University MacPherson Dr Gordon Oxford of University McQueen-Mason Simon Professor York of University Dr Jonathan Powell Research Unilever Rushton Dr Stephen University of Newcastle upon Tyne Shewry Peter Professor Research Rothamsted ShorttProfessor Colette Nutritionals McNeill Tatchell Mark Professor Consultant OBSERVERS Gill Maggie Professor Rural and Environment Executive Scottish Affairs Department Popple Dr Sue Food Environment, for Department Affairs Rural and Wotherspoon Mr Alisdair Agency Standards Food Agri-Food Committee Agri-Food (Chair) Williams Christine Professor Reading of University Barraclough Dr Declan Agency Environment Beckett Dr Steve Ltd York Nestle COMMITTEE MEMBERSHIP MEMBERSHIP COMMITTEE Tools & Resources Panel & Resources Tools FRS (Chair) Dell Anne Professor London College Imperial Ambrose Mr Mike Centre Innes John Archibald Alan Professor Institute Roslin Professor Judy Armitage Oxford of University Burke Dr Julian Genetix Chaplain Mark Professor Dundee of University Cooper Professor Jon Glasgow of University Edwards Keith Professor Bristol of University Gaskell Simon Professor University of Manchester Ghazal Peter Professor Edinburgh of University Lanfear Dr Jerry UK Pfizer Laue Ernest Prof Cambridge of University Molloy Justin Professor Research Medical for Institute National Phillips Simon Professor Leeds of University Pillmoor Dr John York of University Pung Dr Caroline Library British The Dr Jane Memmott Dr Jane Bristol of University Roberts Ian Professor University of Manchester Ward Dr Barrie Pharmaceuticals KuDos Wilkinson Tony Professor York of University Wonnacott Susan Professor Bath of University 38 BBSRC Annual Report & Accounts 2005-06: Management Commentary University of Glasgow Professor Andy Baker Liverpool of University Beynon Robert Professor University of Birmingham Professor Peter Fryer FREng (Chair) Committee Engineering andBiological Systems University of Leeds Dr David Westhead Manchester of University Professor Nigel Scrutton National Institute for Medical Research Dr Justin Molloy University of Dundee Professor BillHunter Sheffield of University Dr Jane Grasby GlaxoSmithKline Dr Colin Edge University of Oxford Dr Benjamin Davis University College London Professor Stephen Caddick University of East Anglia Dr Julea Butt University of Southampton Professor Tom Brown Pfizer UK Dr Dave Brown AstraZeneca Dr Alexander Breeze University of Bristol Dr Paula Booth University of Edinburgh Professor Paul Barlow Imperial College London Professor JimBarber University of York Professor Rod Hubbard (Chair) CommitteeBiomolecular Sciences University of Nottingham Professor Anne Willis University of Edinburgh TonyProfessor Trewavas University of London Professor Anne Stephenson University of Birmingham Dr David Sansom UCB Group Dr Oliver Rausch Sheffield of University Professor Peter Piper Boards, Panels and Committees Research Council Engineering and Physical Sciences Dr Elizabeth Hylton Research Council Engineering and Physical Sciences Dr Stephen Elsby Department of Trade and Industry Dr Martin Anthony OBSERVERS Cambridge Antibody Technology Dr Paul Varley Imperial College London Dr Michael Stumpf Manchester of University Dr Gill Stephens Sheffield of University Professor Graham Leggett Belfast University Queens Dr Michael Larkin University of Leeds Professor Eileen Ingham University Keele Professor Alicia ElHaj Oxford Brookes University Professor David Fell Oxford University Professor Zhanfeng Cui University of Glasgow JonProfessor Cooper AstraZeneca Walter Cook Dr University of Nottingham HelenProfessor Byrne University of Warwick Professor Elizabeth Jones Royal Botanic Garden Edinburgh Dr Peter Hollingsworth GlaxoSmithKline Dr Martin Ford John Innes Centre Professor Enrico Coen FRS Imperial College London Professor Martin Buck University of Leeds Professor Constanze Bonifer University of Edinburgh Professor Mark Blaxter University of Cambridge Professor Michael Akam FRS University of York Professor Ottoline Leyser (Chair) Committee Genes andDevelopmental Biology Scottish Crop Research Institute Dr Robbie Waugh University Open Dr Robert Saunders Lancaster University Dr Clive Price Avlar Bioventures Ltd Dr Cathy Prescott Sheffield of University Professor Marysia Placzek King’s College London Maden Malcolm Professor University of Birmingham Kearsey Mike Professor University of Newcastle upon Tyne upon Newcastle of University Dr AnilWipat Biogemma UKLtd Dr Jeroen Wilmer Imperial College London Dr Huw Williams Scottish Crop Research Institute Dr Lesley Torrance University of St Andrews Dr Alyson Tobin Exeter of University Professor Nic Talbot University of Glasgow Dr Joel Milner Sheffield of University Dr Julie Gray University of York Professor Ian Graham University of Leeds Professor PhillipGilmartin University of Cambridge Dr Paul Dupree John Innes Centre Professor Allan Downie University of Surrey Professor Mike Bushell University of Oxford Armitage Judy Professor AstraZeneca Dr Aileen Allsop Durham University Professor Robert Edwards (Chair) Committee Plant andMicrobial Sciences 39 BBSRC Annual Report & Accounts 2005-06: Management Commentary e iod of of iod f Civil f Civil ££ ££ ££ From 30 Until 2005-06 2005-06 2004-05 1 October 20051 October 2005 September Appointments in £000s Remuneration From To 2004-05 2005-06 Remuneration report air h y C rs e ut p e mb e d D il M air an unc o h C Council ChairCouncil Committees chair also who Members Council MembersCouncil 8,370 8,160 annum per 15,100 6,280 14,700 annum per 6,120 annum per Chair - Dr Peter Ringrose - Dr Peter Chair CE - and Chair Deputy CBE Goodfellow Julia Professor C Bright Simon Professor Brightman Mr David FRS Dalton Howard Professor FRS Delpy David Professor Freedman Robert Professor Gilligan Chris Professor HaywoodMrs Sarah Hunter A Jackie Professor 01/05/2003 01/01/2002 Kell Douglas Professor McKellar Quintin Professor Penman Dr Alistair 30/04/2007 31/12/2007 FRS Rothwell Nancy Dame FRS 20/04/2004 CBE Tickle Cheryll 01/04/2002Professor WeirDr Malcolm 01/08/2003 01/04/2004 is non-pensionabl appointment Chairman's The 01/04/2002 31/03/2007 £14,550). (2004-05: £14,900 of 31/03/2010 honoraria were Chairman the of below below See See emoluments total The 31/03/2009 31/03/2007 01/04/2003 31/03/2008 01/04/2004 6 24/10/2005 payable fee No 31/03/2009 01/04/2005 01/04/2000 6 6 31/03/2007 6 01/04/2001 23/10/2009 01/04/2005 31/03/2008 31/03/2006 6 6 01/04/2002 31/03/2007 6 31/03/2008 6 6 31/03/2008 6 payable fee No 6 6 01/04/2005 6 6 6 6 8 31/03/2008 0 6 6 0 6 8 0 and there is no entitlement to compensation for loss of office. Dr Peter Ringrose was appointed Chairman of the BBSRC for a per for BBSRC the of Chairman appointed was Ringrose Dr Peter office. of loss for compensation to entitlement is no there and 2003. 1 May from years four Councils. Research the of Group Management Financial the by is set Members and Chairs Committee of remuneration The 2006-07. of end the at reviewed will be rates current The ChairmanCommittee Committee Members 215 160 200 day per 150 per day Servants, employees of Research Councils and their institutes and other Non-Departmental Public Bodies and Agencies. and Bodies Public Non-Departmental other and institutes their and Councils Research of employees Servants, was: members Council to paid fee standard The Policy and Trade of Department the by year each are reviewed rates The Councils. Research the across same the are rates Remuneration service. civil senior the to given increase the account into take may Department the rates, new the In considering Industry. in October. is implemented change agreed the and Councils Research the with consults Department The o in respect payable is fee No office. of loss for compensation to entitlement is no there and are non-pensionable Appointments ii) Members and Chairs Committee i) Executive Chief except members Council and Chair Council 40 BBSRC Annual Report & Accounts 2005-06: Management Commentary Definitions of terms used inthis Remuneration Report aregiven on page 62. Chief Executive and Accounting Officer Professor Julia Goodfellow CBE vi) Research Directors of Sponsored Institutes BBSRC Directors v) BBSRC Remuneration Board iv) Chief Executive iii) Remuneration report Remuneration by each institute. each institute. by Details of sponsored research institute Directors’ emoluments arepublished inthe statutory company and charity accounts prepa disclosure of personal information. No Director isinreceipt of benefits inkind. Salaries of Directors areincluded within the analysis by Band (Note 5).AllBBSRC Directors withheld their consent to further Directors areon indefinite contracts, similar to the majority of BBSRC staff, with notice periods between one and three months Dr Doug Yarrow, BBSRC Director of Corporate Science Group Mr Steve Visscher, BBSRC Executive Director Mr Peter Swinburne, BBSRC Director of Human Resources Group Professor Nigel Brown, BBSRC Director of Science and Technology Group BBSRC Directors aremembers of the BBSRC Executive and are: relativities, job weight and any special factors and relativities. Increases arenormally awarded from 1July annually. determining each Director’s annual salary level and any bonus. The Board willalso take account of public sector pay constrain The Board reviews performance against aseries of objectives, categorised between fundamental, value-added or breakthrough, in Policy Council Members, at least one of whom must have anindustry background (page 35). Remuneration Board. The Board ischaired by the Chair of Council and other membership comprises the Chief Executive and three The remuneration of BBSRC Directors and Directors of sponsored institutes isreviewed and adjusted annually by the Council actuarial assumptions. There were no receipts or benefits inkind. pension at 1April 2004 was £47,854. It rose by £42,899 inthe year to £90,753 at 31 March 2006, mainly as aresult of changes appointment willterminate on 31 December 2007. Her total emoluments arebelow. The cash equivalent transfer ofProfessor he value (CETV) Julia Goodfellow CBE was appointed Chief Executive on 1January 2002. Following atwo-year extension her fixed-term p objectives agreed by BBSRC and the Chief Executive. increase up to asalary ceiling. Inaddition, anon-consolidated, non-pensionable annual bonus may be awarded for performance t Subject to successful performance, the Chief Executive’s salary rises by acost of living increase and apre-determined increme Policy Secretary isadvised by aRemuneration Committee chaired by the Director General of Research Councils. The Chair of BBSRC isco The Chief Executive’s remuneration isdetermined by the Permanent Secretary of the Department of Trade and Industry. The Perman Remuneration Committee (Audited information) 2004/05 2005/06 £102,284 £111,818 Salary Date: 3July 2006 £16,035 £11,685 Bonus £1,270 £1,476 earned pension Real increase in £119,589 £124,979 Total earned £3,810 £4,427 pension lump sum Real increase in . ts, ts, ntal owards in nsulted. nsulted. eriod red r ent ent Annual Accounts 2005-06 42 BBSRC Annual Report & Accounts 2005-06 Accounting Officer MemorandumissuedbytheHMTreasury andpublishedwww.government–accounting.gov.uk Accounting Officer isanswerable,forkeepingproper records andforsafeguarding BBSRC’s assets,are setoutintheNDPB responsibilities ofanAccountingOfficer, includingresponsibility forthepropriety andregularity ofthepublicfinancesfor The Secretary ofStateforTrade andIndustryhasdesignatedtheChiefExecutiveasAccountingOfficer ofBBSRC.The Manual (www.financial-reporting.gov.uk) andinparticularto: In preparing theaccounts,AccountingOfficer isrequired tocomplywiththerequirements FinancialRepor oftheGovernment BBSRC andofitsincomeexpenditure, recognised gainsandlossescashflowsforthefinancialyear. Accounts Direction. Theaccountsare prepared on anaccrualsbasisandmustgiveatruefairviewofthestateaffairs o Treasury hasdirected BBSRCtoprepare foreachfinancialyearastatementofaccountsintheformandon thebasissetoutin Under Section2(2)oftheScienceandTechnology Act1965,theSecretary ofStateforTrade andIndustrywiththe consent ofth Statement of Responsibilities of Council and Chief Executive as Accounting Officer BBSRC BBSRC • • • • prepare basis. thefinancialstatementsonagoingconcern and discloseexplainanymaterialdepartures inthefinancialstatements;and state whetherapplicableaccountingstandards FinancialReportingManualhavebeenfollowed, assetoutintheGovernment make judgementsandestimatesonareasonable basis; disclosure requirements, andapplysuitableaccountingpoliciesonaconsistentbasis; observe theAccountsDirection issuedbytheSecretary ofStateforTrade andIndustry, includingtherelevant accountingand Accounts 2005-06 whichthe f the e ting 43 BBSRC Annual Report & Accounts 2005-06

ort n an ent of ent of icies, oversee

March utes are nage f hieve he evidence Accounts 2005-06 Accounts BBSRC Core Strategic Grant funding by the end of 2005/06. Core of Information Act. Freedom of those at corporate level. Additional support has been provided by introducing a formal PRINCE 2 based project management management 2 based project a formal PRINCE by introducing has been provided of those at corporate level. Additional support of four grant major activities, such as the introduction with risk management embedded in it. This has been used for approach in Swindon Office. on all members of the largest Group which impacted directly rounds, The Board reviews the external audit management letters arising from BBSRC and from the BBSRC sponsored institutes and the BBSRC sponsored BBSRC and from the external audit management letters arising from reviews The Board the internal plan for the year in the light of the key risks identified as part of the risk management approves audit programme o picked out for special assessment by BBSRC Executive and Audit Board are business critical projects framework. In particular, instit Councils’ Internal of the BBSRC and its sponsored ongoing basis. The activities of the Research Audit Service in respect which is based on the overall assessm and the scope of the internal audit plan for the coming year, by the Audit Board reviewed t in evaluating and reviewing role plays a pivotal With Audit Board view of audit activities, risk, is agreed. this overarching risk management is to in terms of role assurance statement on internal The Council’s control. supporting the Chief Executive’s minutes and periodic oversight of the BBSRC Risk Inventory. of Audit Board review through the work of the Audit Board and framework and the strategic and operational risk management registers review regularly The BBSRC Executive and Audit Board the year. pertaining through on the business critical projects reports receive 2006 is: The status of these at 31 March 1. of SRI following withdrawal of all BBSRC restructuring Institute (SRI) Restructuring. Complete. The orderly Silsoe Research 4. The Risk and Control Framework Control and Risk The 4. during the year. basis by the BBSRC Executive and Audit Board on a regular is considered Risk management and internal control institutes. arrangements for BBSRC and the sponsored in overseeing the internal control plays an important role The Audit Board 2. to the response of Information Act. Complete. The successful implementation of BBSRC’s Implementation of Freedom 3. Capacity to Handle Risk by a number of means, including: BBSRC gives leadership to the process 1)risk management policy and strategy; setting out a 2) institutes; management assurance statements at the most senior levels within BBSRC and its sponsored signing up to risk 3) of key risks at least quarterly. the register reviewing updating and 4) in supp level risk registers the development and implementation of Group level through at staff is reinforced Risk management BBSRC’s policies, aims and objectives, whilst safeguarding the public funds and department assets for which I am personally the public funds and department aims and objectives, whilst safeguarding policies, BBSRC’s to me in Government assigned Accounting. the responsibilities with in accordance responsible, safe and effici effective, for the BBSRC, responsible of the Accounting Officer has designated me as The DTI Accounting Officer Statement. with the Management in accordance operation of the Council to ac rather than eliminate all risk of failure level risk to a reasonable is designed to manage The system of internalcontrol The system and not absolute assurance of effectiveness. reasonable only provide policies, aims and objectives; it can therefore pol prioritise the risks to the achievement of BBSRC’s designed to identify and internal is based on an ongoing process control and to ma and the impact should they be realised, of those risks being realised aims and objectives, to evaluate the likelihood has been in place in BBSRC for the year ended 31 The system of internal control and economically. effectively them efficiently, guidance. with Treasury and accounts, and accords of the annual report 2006 and up to the date of approval 2. The Purpose of the System of Internal Control Internal of System the of Purpose 2. The Statement by Chief Executive on Internal Control Control Internal on Executive Chief by Statement Responsibility of Scope 1. supports the achievement o that maintaining a sound system of internal for control I have responsibility As Accounting Officer, also considered. of key stakeholders and operational partners are The interests 44 BBSRC Annual Report & Accounts 2005-06 . IAHPirbrightRedevelopment.Continuing.Theproject isplannedtoreplace thecurrent, verymixed,facilitieswithstate-of 5. Introduction offourGrantRounds. Complete.Successfuldeliveryoffourgrantrounds peryeartomaintaintheBBSRC’s 4. BabrahamBioscienceTechnologies Ltd,SiteDevelopment.Complete.ThesuccessfullettingoftheBio-Development 3. rfso ui odelwCEDate: 3July2006 Chief ExecutiveandAccountingOfficer Professor Julia GoodfellowCBE making process. are managed appropriately. Thisisnotbasedonaculture ofriskaversionbutone where risksare considered aspartofthede In general,controls are inplacewhichcanprovide areasonable degree ofassurancethatoperational,financialandreputation within thecharitysectorandtounderpinBBSRC’s approach. The BBSRCsponsored instituteshavetheirownRiskManagementAssuranceFrameworkaspartoftheaccountingrequirements control gapsexist. frameworks developedbyBBSRCanditssponsored institutesandresponsesmanagementletterswhichidentifywhere toexternal Executive includingthereview ofBusinessCriticalprojects, theannualreport fromAudit, theriskmanag theHeadofInternal The principalelementsofsupportfortheAccountingOfficer’s assurancestatementare theworkofAuditBoard andtheBBSR continuous improvement ofthesystemisinplace. the effectiveness control ofthesysteminternal bytheCouncilandAuditBoard andaplantoaddress weaknesses andens auditorsintheirmanagementletterandotherreports.external Ihavebeenadvisedontheimplicationsofresult ofmyrev BBSRC whohaveresponsibility control forthedevelopmentandmaintenanceofinternal framework,andcommentsmadebythe effectiveness controlauditors,andtheexecutivemanagerswi ofthesysteminternal isinformedbytheworkofinternal As AccountingOfficer, Ihaveresponsibility forreviewing theeffectiveness control. ofthesysteminternal Myreview ofth 5. Review of Effectiveness economic costing. BBSRC isworkingwiththeotherResearch Councilstodevelopthisapproach furthertotakeaccountoftheintroduction offull organisations. Thetestingbroadly looksatoverallsystemsofcontrol andisanimportantelementoftheriskmanagementframe Research CouncilscarryoutDipstickTesting, whichreviews expenditure ontheirresearch grantsatuniversitiesandotherrese ImpactofDefrafundingchangesoninstitutesustainability. NewsinceMarch 2006.Seeking long-termfundingagreements 9. Instituterestructuring programme. Continuing.Managingthesuccessfuldeliveryofredundancy programmes atBBSRC- 8. NewEdinburghinstituteinitiationproject. Continuing.Settingupanewresearch instituteinEdinburghbringingtogether 7. IAHRecoveryPlan.Continuing.Therestructuring oftheInstituteforAnimalHealthincludingaredundancy programme, 6. BBSRC BBSRC credibility withthewidercommunity. building atthecentre oftheBabrahamResearch Campus,fullyletbyJuly2005. secure sustainability. with Defraforrelevant BBSRC-sponsored institutesinlinewithRIPSSprinciplestoprotect strategicareas ofscienceand sponsored institutes. of theUniversityEdinburgh. researchers from theRoslinInstitute,current IAH Neuropathogenesis UnitandtheRoyal(Dick)SchoolofVeterinary Studies development ofanewsciencestrategyandmanagementstructure andsystems. the Veterinary LaboratoriesAgencyofDefra. flexible facilitiesincludingareas withthehigherlevelofbio-security. Thisisalliedtotherelocation oftheVirology Dep Accounts 2005-06 artment of e -the-art ement iew of thin al risks arch cision work. ure

C 45 BBSRC Annual Report & Accounts 2005-06 nd Statement of Total he Science and Technology he Science and Technology thereunder by the Secretary by the Secretary thereunder transactions conform to the Accounts 2005-06 Accounts for Trade and Industry for Trade set out within them. March 2006 and of its surplus for March nce with HM Treasury’s guidance nce with HM Treasury’s egularity of financial transactions. Council and Chief Executive in ements in accordance with the ements in accordance of the Management Commentary. I of the Management Commentary. d by Parliament and the financial oard. My audit includes oard. received all the information and all the information received provide me with sufficient evidence me with sufficient provide material misstatement, whether resentation of information in the resentation nd Biological Sciences Research purposes intended by Parliament and corporate governance procedures or corporate governance procedures nancial statements. My responsibilities s and the part of the Remuneration ar ended 31 March 2006 under the ar ended 31 March ’s statements on internal cover control ’s ort is not consistent with the financial atements. This other information BBSRC International Standards on Auditing (UK International Standards d in the financial statements and the part actions is not disclosed. London SW1W 9SP the financial statements give a true and fair view, in accordance with the Science and Technology Act 1965 and directions made Act 1965 and directions with the Science and Technology in accordance the financial statements give a true and fair view, of State for Trade and Industry, of the state of the Biotechnology and Biological Sciences Research Council’s affairs as at 31 affairs Council’s of the state of the Biotechnology and Biological Sciences Research and Industry, of State for Trade the year then ended; with t in accordance prepared the financial statements and the part of the Remuneration Report to be audited have been properly and made thereunder; and Industry directions of State for Trade Act 1965 and Secretary income have been applied to the purposes intended by Parliament and the financial and the expenditure in all material respects authorities which govern them. • • • Opinions In my opinion: I have no observations to make on these financial statements. John Bourn and Auditor GeneralComptroller 6 July 2006Buckingham Palace Road 157-197 National Audit Office Victoria Basis of audit opinions audit of Basis by the Auditing Practices B issued with International on Auditing (UK and Ireland) I conducted my audit in accordance Standards examination, on a test basis, of evidence relevant to the amounts, disclosures and regularity of financial transactions include and regularity to the amounts, disclosures examination, on a test basis, of evidence relevant an assessment of the significant estimates and judgments made by the of the Remuneration Report to be audited. It also includes to the Biotechnology a most appropriate financial statements, and of whether the accounting policies are of the the preparation consistently applied and adequately disclosed. circumstances, Council’s to necessary in order I planned and performed my audit so as to obtain all the information and explanations which I considered from free Remuneration Report to be audited are assurance that the financial statements and the part of the to give reasonable and income have been applied to the purposes intende the expenditure and that in all material respects caused by fraud or error transactions conform to the authorities which govern them. In forming my opinion I also evaluated the overall adequacy of the p financial statements and the part of the Remuneration Report to be audited. Respective responsibilities of the Council, Chief Executive and Auditor and Executive Chief Council, the of responsibilities Respective Report and the financial stat the Annual Report, the Remuneration for preparing responsible are The Council and Chief Executive Certificate and Report of the Comptroller and Auditor General to the Houses of Parliament of Houses the to General Auditor and Comptroller the of Report and Certificate Council for the ye Sciences Research financial statements of the Biotechnology and Biological I certify that I have audited the Science and Technology Act 1965. These comprise the Income and Expenditure Account, the Balance Sheet, the Cashflow Statement a Account, the Balance Sheet, 1965. These comprise the Income and Expenditure Act Science and Technology under the accounting policies These financial statements have been prepared notes. and the related Recognised Gains and Losses r and for ensuring the made thereunder and Industry directions of State for Trade 1965 and Secretary Act Science and Technology Accounting Officer. of Responsibilities of Council and Chief Executive as set out in the Statement are These responsibilities and with requirements, legal and regulatory with relevant audit the financial statements in accordance is to My responsibility and Ireland). as to whether the financial statements give a true and fair view and whether the financial statement to you my opinion I report of State Act 1965 and Secretary with the Science and Technology in accordance prepared Report to be audited have been properly and income have been applied to the the expenditure whether in all material respects I also report made thereunder. directions to you if, in my opinion, the Annual Rep governthe financial transactions conform to the authorities which them. I also report if I have not accounting records, Council has not kept proper Research statements, if the Biotechnology and Biological Sciences and other trans remuneration authorities regarding for my audit, or if information specified by relevant explanations I require complia Council’s Research the Biotechnology and Biological Sciences statement on pages 43 and 44 reflects whether the I review to consider whether the Accounting Officer if it does not. I am not required on the Statement on Internal and I report Control, Council’s Sciences Research of the Biotechnology and Biological or form an opinion on the effectiveness all risks and controls, procedures. its risk and control contained in the Annual Report and consider whether it is consistent with the audited financial st the other information I read and the rest the unaudited part of the Remuneration Report, report, statement, Chief Executive’s comprises only the Chairman’s misstatements or material inconsistencies with the fi of any apparent if I become aware consider the implications for my report do not extend to any other information. 46 BBSRC Annual Report & Accounts 2005-06 The Notesonpages49to61form partoftheseAccounts. All activitiesare regarded ascontinuing. oinlItrs 6c 8 Net Gainondisposalsanddemolitionoffixedassets Notional Interest eeslo oinlItrs 6c Reversal ofNotionalInterest rnfr rmrvlainrsre10 Transfers from revaluation reserve Surplus brought forward Surplus/(Deficit) afterreversal ofNotionalInterest GENERAL RESERVECARRIED FORWARD 5 SURPLUS/(DEFICIT) FOR THEYEAR 4 4 2 10 OPERATING SURPLUS/(DEFICIT) FOR THEYEAR Staff costs Training Awards andFellowships Research andCapitalGrants EXPENDITURE granttransfer Government Revenue Grant-in-aid INCOME year ended 31 March 2006 Income &Expenditure Account for the ercainadipimn 9 Depreciation andimpairment te prtn ot 6a 7 3 Research Institutestaff restructuring Other operatingcosts Other Income BBSRC BBSRC Accounts 2005-06 OE£00£’000 £’000 NOTE 264,861 320,569 39,129 13,092 8,586 3,117 7,463 3,325 6,965 2005-06 (330,329) 336,778 15,610 (7,268) 2,660 6,449 7,268 1,841 4,399 2,102 9,109 (302,254) 2004-05 234,093 275,460 289,730 (12,524) (18,524) (11,340) 33,666 15,458 10,853 (7,184) 1,184 7,184 2,102 4,808 8,634 £’000 6,975 3,417 5,827 6,235 47 BBSRC Annual Report & Accounts 2005-06 701 (130) 2,102 3,104 £’000 1,000 13,084 30,856 17,772 40,517 33,960 18,910 (15,050) (16,678) 162,056 221,483 204,675 204,675 200,872 202,573 31 March 2005 31 March - Accounts 2005-06 Accounts (9,339) 38,636 15,610 24,949 158,370 221,955 212,616 212,616 197,006 BBSRC 31 March 2006 31 March 220 6,005 1,000 32,163 10,585 21,578 38,168 (13,219) 195,786 NOTE £’000 £’000 - due after one year 13(ii) - due within one year 13(i) Cash at bank and in hand 17(iii) Revaluation reserveGeneral reserve FUNDS GOVERNMENT TOTAL 10 NET ASSETS by: Financed RESERVES Government Grant Reserve 10 TOTAL ASSETS LESS CURRENT LIABILITIES CURRENT ASSETS LESS TOTAL TERM LIABILITIES LONG falling due after one yearCreditors 14b CURRENT LIABILITIES CURRENT falling due within one yearCreditors ASSETSNET CURRENT 14a CURRENT ASSETSCURRENT Debtors: FIXED ASSETS FIXED Intangible 9 Balance Sheet Sheet Balance 2006 March 31 at as Provisions for liabilities and chargesProvisions 15 The Notes on pages 49 to 61 form part of these Accounts. Professor Julia Goodfellow CBEProfessor Chief Executive and Accounting Officer Date: 3 July 2006 Tangible 11 Investments 12 48 BBSRC Annual Report & Accounts 2005-06 The Notesonpages41to61form partoftheseAccounts. 10 10 2 10 Deferred Capital Grant-in-aidreduces theTotal RecognisedGainforthat year. Following itsredesignation GrantReserve(see Note 10),the2004-05decrease asthemovementinGovernment of£2,295in Professional revaluation Valuation additions Grantreserve Release toincomeofGovernment Capital Grant-in-aidreceived Reversal ofNotionalInterest eepsfo aeo ie ses17(vi) Receipts from saleoffixedassets TOTAL RECOGNISED GAINS ANDLOSSES FOR THEYEAR SURPLUS/(DEFICIT) FOR THEYEAR 2 for year ended 31 March 2006 Statement of Total Recognised Gains and Losses 17(v) INCREASE IN CASH INFLOWNET CASH FROM FINANCING 17(v) Capital Grant-in-aidreceived FINANCING INFLOW/(OUTFLOW)NET CASH BEFORE FINANCING INFLOWNET CASH FROM CAPITAL EXPENDITURE ANDRECEIPTS Purchase ofinvestments Payments toacquire tangiblefixedassets CAPITAL EXPENDITURE INFLOW/(OUTFLOW)NET CASH FROM OPERATING ACTIVITIES for the year ended 31 March 2006 Cash Flow Statement BBSRC BBSRC Accounts 2005-06 OE£00£’000 £’000 NOTE 17(ii) 17(i) 1,813 1,236 (863) (500) 2005-06 2005-06 (3,117) 1,236 1,665 7,941 1,300 1,236 7,268 1,841 1,215 £’000 2,901 (587) 450 2004-05 2004-05 (18,524) (2,567) (1,198) (3,417) 2,298 3,582 £’000 £’000 1,122 8,415 4,022 1,122 7,184 1,122 (750) (269) (534) 853 49 BBSRC Annual Report & Accounts 2005-06 s. . ed s. also the eir which at each for non- n the year uction or f each asset Accounts 2005-06 Accounts BBSRC (or group of assets) to its estimated residual value evenly over its expected useful life. An expected useful life is assessed of assets) to its estimated residual (or group is charged i depreciation in the year of acquisition whilst a full year’s not depreciated Buildings are location by the valuer. as follows: of disposal. Expected useful lives are Land Freehold cost buildings replacement Depreciated Agricultural buildingsDwellings - and Computing EquipmentOffice System SoftwareMotor Vehicles up to 60 years Assets Under Construction - - - 3 to 5 years not depreciated up to 60 years - - - - into use until brought not depreciated 5 years up to 60 years up to 4 years specialised buildings. Valuations are adjusted annually to the Balance Sheet date by using appropriate published indices and published appropriate adjusted annually to the Balance Sheet date by using are specialised buildings. Valuations five years except for buildings under constr of land and buildings is carried out at least every statistics. A full revaluation for sale. sites being prepared purposes. for valuation and depreciation lives have been grouped Some buildings with similar remaining and this position is kept under review. these assets have not been revalued cost. Accordingly current general reserve. On disposal of a revalued asset, that element of the revaluation reserve that becomes realised as a result is as a result that becomes realised reserve asset, that element of the revaluation On disposal of a revalued general reserve. to the general reserve. transferred and Industry, pursuant to Section 2 (2) of the Science and Technology Act 1965 and follow the 2005/06 Government Act 1965 Financial the Science and Technology pursuant to Section 2 (2) of and Industry, follow UK generally The accounting policies contained in the FReM www.financial-reporting.gov.uk. Reporting Manual (FReM) to the public sector. that it is meaningful and appropriate for companies (UK GAAP) to the extent accepted accounting practice the account to material in relation in dealing with items considered policies have been applied consistently accounting BBSRC’s are leased to a number of grant-aided institutes, all of whom are constituted as companies limited by guarantee and as register constituted as companies limited leased to a number of grant-aided institutes, all of whom are are sources or in part from separate audited accounts. Additions to these assets may be funded wholly charities who prepare Grants in made by BBSRC, in the form of capital grants, is included within Research other than BBSRC. Any funding contribution Account. the Income and Expenditure owned assets, this is in a material change in the value of the Council’s institutes carry out developments that result Where valuation at the Balance Sheet date these accounts based on a professional disclosed as a fixed asset valuation addition within iv) to reserve the revaluation matched by annual transfers from are the revaluation charges arising from depreciation Increased vi) the cost or the valuation o on all tangible fixed assets at rates calculated to write off is made for depreciation Provision iii) cost in the case of specialised scientific buildings or open market value replacement The basis of valuation is depreciated v) and th and fittings equipment, fixtures between the historic cost of is no material difference opinion of BBSRC, there In the i)land and buildings. milk quotas, or more, of equipment valued at £3,000 includes the purchase Capital expenditure ii) included at cost or valuation in existing use. The Council owns land and buildings, and intangible fixed assets are Tangible b) Accounting Convention i) of fixed asset modified to account for the revaluation under the historical cost convention been prepared These accounts have c) Assets Fixed Intangible and Tangible i) of State for Trade issued by the Secretary with the Accounts Direction in accordance These accounts have been prepared Notes to the Accounts the to Notes POLICIES ACCOUNTING 1. a) Accounting of Basis 50 BBSRC Annual Report & Accounts 2005-06 )Provisions k) Notional Interest j) Retirement Costs i) Value Added Tax h) Foreign Currencies g) Research Grants f) Grant-in-aid e) Ownership of Equipment Purchased with BBSRC Researchd) Grants Investments c) BBSRC BBSRC balance released oncetheredundancies are complete. provision for theon-goingAnnualCompensationPaymentsistransferred from theMajorInstituteRestructuringandanyremaining When BBSRChastakenadecisiontofundprogramme ofredundancies, thentheassociated costsare provided for. The with HMPaymasterGeneral. rate setbyHMTreasury (currently 3.5percent)ontheaverageofopeningandclosingassetslessliabilities,exceptforbala A charge,reflecting thecostofcapitalutilisedbyCouncilisincludedinoperatingcosts.Thechargecalculatedatth age. Recoverableamountsare recognised asdebtorsintheseaccountsandsetoff againstannualstaff restructuring costs. retirement lumpsumsare recoverable from theResearch Councils'Pension Schemeswhenrecipients reach normalretirement Contributions topensionschemes(currently 21.3percent)are recorded asexpenditure. PaymentsbytheCouncilofearly Expenditure accountasmiscellaneoussundryincome.IncomeisshownnetofVAT. where applicable.Residualinputtaxreclaimable bytheapplicationofpartialexemptionformulaistakentoIncomeand As theCouncilispartiallyexemptforVAT purposes,allexpenditure and fixedassetadditionsare showninclusiveofVAT to theIncomeandExpenditure account. Transactions inforeign currencies are recorded at the raterulingattimeoftransaction.Allexchangedifferences are Assets andLiabilitiesdenominatedinforeign currencies are translatedattheratesofexchangeruling the balancesheetda Research grantsare charged totheIncomeandExpenditure accountintheperiodtowhichitrelates. related assets. of fixedassetsiscreditedGrantreserve. totheGovernment Thisisreleased toincomeovertheestimatedusefullivesof Grant-in-aid forrevenue purposesiscredited toincomeintheyearwhichitisreceived. Grant-in-aidappliedforthepurch the righttodeterminehowsuchequipmentshallbedisposedofandanydisposalproceeds are tobeutilised. therefore tangiblefixedassetsoftheCouncil.Through theConditionsofGrantappliedtofundedinstitutions,Councilres Equipment purchased byaninstitutionwithresearch grantfundssuppliedbytheCouncilbelongtoinstitutionandare not Investments are statedatcostlessprovision foranyimpairmentinvalue. published yearendpriceperlitre. listed marketprice–www.mdcdatum.org.uk/farmdata/quotaprices. Theyare notamortisedbutrevalued eachyearusingthe Milk Quotaare rightsgainedbyusinglandformilkproduction inthepast.Theyare tradableonestablishedmarketsandhavea Accounts 2005-06 e real taken nces ase erves te.

51 BBSRC Annual Report & Accounts 2005-06 - 969 553 232 125 6,952 5,305 3,669 3,901 £’000 £’000 £’000 (1,122) 33,666 89,481 10,166 15,729 15,301 10,853 34,938 58,434 267,759 168,112 267,759 234,093 109,691 275,460 276,582 2004-05 2004-05 2004-05 - 654 166 102 Accounts 2005-06 Accounts 5,949 4,562 1,659 1,825 £’000 £’000 £’000 (1,236) 39,129 16,866 24,695 11,267 13,092 45,246 12,962 66,574 303,990 182,502 104,622 303,990 264,861 115,384 320,569 321,805 2005-06 2005-06 2005-06 BBSRC Universities Research Institutes Research Other Research Councils and other organisations Other Research - Other recoveries - IT Services to Institutes Beneficiaries: Training Awards and Fellowships Awards Training Capital and Buildings Joint Infrastructure Fund Joint Infrastructure Other Operating Income Equipment and Facilities TOTAL Other Research Councils and Government Departments Other Research Research Initiatives Research 4. AWARDS AND TRAINING GRANTS RESEARCH & CAPITAL Recoveries of Costs Recoveries 3. OTHER INCOME 3. OTHER Responsive Research Grants Responsive Research Grant-in-aid RfR 2 Subhead W Pirbright Redevelopment Funding Strategic Grants Core 2. GRANT-IN-AID Amount provided by the Office of Science and Technology of Science and Technology by the Office Amount provided under Request for Resources (RfR) 2 Subhead 0 under Request for Resources to Government Grant Reserve (See Note 10) transferred received Less Capital Grant-in-aid Revenue Grant-in-aid 52 BBSRC Annual Report & Accounts 2005-06 Remuneration includesEmployers' Pension SchemeContributionsof21.3%(2004-05:10.1%) £60,000 to£69,999 £70,000 to£79,999 £80,000 to£89,999 £90,000 to£99,999 £100,000 to£109,999 £110,000 to£119,999 £120,000 to£129,999 Administrative AVERAGE STAFF NUMBERS ANDFULL TIME EQUIVALENTS (FTE) FOR BBSRC OFFICE, BIOSCIENCE IT SERVICES(BITS) ANDHOSTED COUNCILS' RESEARCH JOINT SERVICES STAFF COSTS 5. FALLING WITHIN THEFOLLOWING RANGES: THE FOLLOWING NUMBER OF EMPLOYEES EXCLUDING THECHIEF EXECUTIVE RECEIVED REMUNERATION Salaries andwages BITS Social Securitycosts Administrative andBITSstaff onpayroll Pension costs Joint Services Administrative andBITSstaff onpayroll Other feesandhonoraria Staff onpayroll Temporary AdministrationandBITSagencystaff Less JointServicesstaff Temporary agencystaff TOTAL In accordanceReportingManual,thetableaboveisofFTEstaff withtheGovernment numbersinsteadofheadcountsasinpreviou Details ofthepensionschemeare onpage33. Further informationonstaff numbersandpensionsare containedinthemanagementcommentaryandremuneration report. from 10.1%to21.3%. In accordance withTreasury guidance,from 1April2005theEmployer'sPensionContributionratewasincreased BBSRC BBSRC Accounts 2005-06 2005-06 2005-06 050 2004-05 2005-06 (2,006) 10,381 178.4 £’000 7,848 1,578 220.2 8,375 280.2 284.6 8,586 41.8 60.0 624 331 211 o No. No. 4.4 51 31 21 1- 1- 1- -1 FTE 2004-05 2004-05 (1,670) £’000 170.6 7,119 212.1 8,561 6,891 271.4 273.5 6,975 s years. 41.5 59.3 553 678 211 2.1 84 53 BBSRC Annual Report & Accounts 2005-06 e 43 760 487 188 704 367 874 592 236 f r 6,235 9,309 1,984 6,975 7,184 £’000 (3,901) 2004-05 ncil has no 44 964 216 547 620 857 460 278 Accounts 2005-06 Accounts 6,965 1,915 8,586 1,064 7,268 £’000 (1,825) 13,726 2005-06 BBSRC Other Expenditure on publications and publicity (2004-05: £51,000) have been included in 6a. Other. on publications and publicity (2004-05: £51,000) have been Expenditure in Employer's Pension contribution on 2005-06. costs include a £750,000 increase Staff by BBSRC, of Bioscience IT Services (BITS) being partially funded directly of costs is as a result in recovery The reduction in the comparative year. institutes as occurred the BBSRC sponsored all of their cost from rather than recovering Net administration and programme costs Net administration and programme Recovery of costs (See Note 3) Central Purchasing by BITS Central Purchasing Internal audit supplies Office Computing expenses subsistence and hospitality Travel, fees and management consultancy Professional 6c. NOTIONAL INTEREST NOTIONAL 6c. 6b. CALCULATION OF NET COSTS OF CALCULATION 6b. costs (See Note 5) Staff 6a. OTHER OPERATING COSTS OPERATING OTHER 6a. This notional cost is included in the accounts to reflect a cost for the use of capital in the business in the year, as the Cou of capital in the business in the year, a cost for the use to reflect This notional cost is included in the accounts guidance, the calculation is based on a 3.5% (2004-05: 3.5%) rate o with Treasury bearing debt. In accordance specific interest £207.7M (2004-05: £204.0M) excluding the averag or valuation. The net assets were return on average net assets employed at cost £1.0M (2004-05: £1.3M). cash balance with the Paymaster General of NDPB with Treasury Account in accordance in the Income & Expenditure notional cost is subsequently reversed The reported Limit (DEL) unde Departmental Expenditure in the Council’s reported as Cost of Capital is, however, Guidance. Notional Interest envelope account to Treasury. control it forms part of Council's Resource Accounting and Budgeting where Resource Maintenance, repairs and cleaning Maintenance, repairs Rent, rates and insurance External audit 54 BBSRC Annual Report & Accounts 2005-06 7. INSTITUTE RESEARCH STAFF RESTRUCTURING 8. NETGAIN ON DISPOSALS OR DEMOLITION OF FIXED ASSETS Annual CompensationPayments(ACP) Net Gain Receipts ondisposalsoffixedassets Redundancy payments Less: NetBookValue ofassetssold/demolished Provided for(SeeNote15) Early Retirement LumpSums(ERLS) Increase provision forACPandrestructuring cost(SeeNote15) Recoverable ERLS Net Cost Release from existingrestructuring provisions (SeeNote15) Recoverable ACPandredundancy payments Other costs This NotenowshowsACPandredundancy paymentsgross ofcostsprovided forbyexistingprovisions. The totalnumberofredundancies during2005-06was274(2004-05:108). BBSRC BBSRC Accounts 2005-06 2005-06 2005-06 (10,194) 11,571 17,449 (2,977) (1,239) (3,808) £’000 £’000 2,340 2,660 2,713 2,991 4,094 3,325 470 547 (53) 2004-05 2004-05 14,815 15,458 (2,398) (1,839) (1,098) (1,207) £’000 £’000 1,772 1,184 3,582 1,633 1,098 4,787 643 284 - 55 BBSRC Annual Report & Accounts 2005-06 Accounts 2005-06 Accounts BBSRC £’000 £’000 £’000 (3,117) (4,399) (7,516) 38,636 158,370 197,006 197,006 38,636 158,370 RESERVE RESERVE -- 2,536 2,036 500 (53) - (53) 220 195,786 1,000 197,006 1,000 220 195,786 599 292,004 293,603 1,000 220 195,786 1,000 197,006 852 310,465 852 310,465 312,317 1,000 701 200,872 202,573 1,000 (379) (96,218) - (96,597) (151) (109,593)(228)(253) (6,735) - (109,744) (334) (500) (7,463) - (587) £’000 £’000 £’000 £’000 GOVERNMENT GRANT REVALUATION Total Milk Quota (See Note 11) (See Note 12) INTANGIBLE TANGIBLE INVESTMENTS Total At cost or valuation Depreciation and impairment Depreciation Depreciation and impairment Depreciation Net Book Value At cost or valuation - To match depreciation- To match net book value of disposals- To (37) (3,080) (16) (4,383) (53) (7,463) 10. FINANCING OF FIXED ASSETS FIXED OF FINANCING 10. Professional revaluationProfessional 2006 At 31 March 2004-05 has with the Government Capital Grant-in-aid in In accordance Financial Reporting Manual, financing classed as Deferred as the Government Grant Reserve. been redesignated * See Accounting Policies (c) (ii) - (587) (587) At 1 April 2005 and valuation additions*Capital expenditure Account / General Reserve: to Income and Expenditure Releases and Transfers 1,236 1,300 2,536 40,517 162,056 202,573 9. FIXED ASSETS 9. FIXED Comprising: Depreciation and impairment Depreciation Disposals revaluation Professional 2006 At 31 March Net Book Value Additions including valuation additions* Additions including valuation At 1 April 2005 56 BBSRC Annual Report & Accounts 2005-06 Land andCompletedBuildings: Analysis ofLandandBuildings 11. TANGIBLE FIXED ASSETS accordance withSAVP andRICSguidancenotesexceptfortwositesthatare beingprepared forsale. The landandbuildingswere professionally valuedasat31March valuers,PowisHughesChartered 2006byexternal Surveyors, in Net BookValue Depreciation Cost orValuation * SeeAccountingPolicies(c)(ii) Comprising: Total LandandBuildings Buildings UnderConstruction Research andAdministrationBuildingsatInstitutes t1Arl20 9,8 0 130 200,872 1,390 96,218 1,550195,786 2,679 100 1,300 - 199,382 292,004 192,936 4,229 Swindon Office 93,539 Institute OccupiedLandandBuildings Dwellings atInstitutes 1,300 286,475 At 1April2005 At 31March 2006 At 31March 2006 revaluation Professional Disposals Provided duringtheyear At 1April2005 At 31March 2006 revaluation Professional Disposals Reclassification Valuation additions* Additions At 1April2005 Long Leasehold Freehold BBSRC BBSRC Accounts 2005-06 Completed Under Plant & adad Buildings Land and ulig osrcinEupetTotal Equipment Buildings Construction 0,9 2,497 109,593 107,096 - 306,478 100 3,887 310,465 1,0)- - (19,908) - - (19,908) 1,7)- -(19,574) - - (19,574) ’0 ’0 ’0 £’000 £’000 £’000 £’000 ,7 - 6 6,735 561 - 6,174 15 34 (589) (394) - (195) 17 39 (536) (379) - (157) 0 10 - - 100 (100) 3 736 736 - 1,300- 1,300 - - 2005-06 189,054 164,412 192,936 194,236 194,201 194,236 24,642 £'000 3,882 1,300 35 2004-05 196,002 159,402 199,382 199,482 199,393 199,482 36,600 £'000 3,380 100 89 57 BBSRC Annual Report & Accounts 2005-06 3,766 9,318 1,057 8,201 2,579 4,265 2,727 9,571 4,625 2,519 £’000 13,084 30,856 17,772 2004-05 903 Accounts 2005-06 Accounts 1,584 7,113 4,626 10,585 32,163 14,465 21,578 Movements31 March At BBSRC 2005-06 - (500) (500) 5,061 5,524 2,848 4,621 6,996 £’000 £’000 £’000 £’000 £’000 1,000 0 1,000 At 1 April 2005 in year 2006 Repayment of Early Retirement Lump Sums* Repayment of Early Retirement Other Prepayments and accrued income: Prepayments grants - Research awards - Training - Other Repayment of Early Retirement Lump Sums* Repayment of Early Retirement Other debtors Trade debtors Trade - At Completion of Agreement to Purchase £250,000 to Purchase - At Completion of Agreement - On 1st June 2004 £750,000- On 1st June 2005 £500,000- On 1st June 2006 £500,000 250 - 750 250 - - 500 750 500 *Cash received from Research Councils' Pensions Schemes (RCPS) in 2005-06 in repayment of Early Retirement Lump Sums (ERLS) of Early Retirement Councils' Pensions Schemes (RCPS) in 2005-06 in repayment Research from *Cash received was £1,155,000 (2004-05: £1,146,000). 13. DEBTORS 13. 12. INVESTMENTS 12. ii) Due after one year: i) Due within one year: Impairment Cost or Valuation PBL of the one third representing at 10p each, Shares 110 Ordinary subscription capital of Plant Bioscience Ltd at a total issued share in four instalments of: price of £2,000,000 payable and Wales. Plant Bioscience Ltd is incorporated in England 2006. 75% part paid at 31 March were The shares RBL 49 per cent of at 100p each representing Shares 49 Ordinary Ltd fully paid. capital of Roslin BioCentre the issued share Ltd is incorporated in Scotland. Roslin BioCentre Rainbow Seed Fund Partner's capital fund investment of £92 ------58 BBSRC Annual Report & Accounts 2005-06 rvsosfr nulMjrIsiueTotal MajorInstitute Annual Provisions for: 15. PROVISIONS FOR LIABILITIES ANDCHARGES rnfr ewe rvsos66 66 - (10,194) (1,239) 9,339 4,094 (9,355) (1,239) (696) 6,537 3,851 (839) - 696 2,802 243 strategies andtheredeployment ofCore StrategicGrantfunding. Councils' PensionSchemes.Themajorinstituterestructuring relates toredundancies duetotheimplementation ofrevised scien Annual CompensationPayments(ACPs)are paymentstoearlyretirees inadvanceoftheirpensionentitlements undertheResearch Total Provisions At31March 2006 Amount expendedinyear Transfers betweenprovisions Amount released inyear Amount provided inyear At 1April2005 rfsinlrvlain 57 (587) 212,616 - 15,610 1,841 (587) 7,268 158,370 1,841 38,636 7,268 204,675 - 2,536 - 2,102 - - 162,056 - - 40,517 1,300 1,236 At 31March 2006 Professional revaluation Expenditure Account /GeneralReserve: Releases andTransfers toIncomeand Capital expenditure andvaluationadditions Reversal ofNotionalInterest Surplus fortheyear At 1April2005 16. RECONCILIATION OF MOVEMENTS IN GOVERNMENT FUNDS Purchase oftangiblefixedassets Deferred income Other creditors Purchase oftangiblefixedassets Trade creditors 14b. CREDITORS: Amounts falling due after one year 14a. CREDITORS: Amounts falling due within one year Accruals: omthntbo au fdsoas(7 1)1 (37) (3,080) 4,383 16 (4,383) (16) (3,080) (37) - To matchnet bookvalueofdisposals - To match depreciation - Other - Research grants BBSRC BBSRC Accounts 2005-06 rn eev eev Reserve Reserve Grant Reserve oenetRvlainGnrl Total General Revaluation Government opnainRestructuring Compensation amns(SeeNote22) Payments 11,115 2,702 13,976 16,678 ’0 £’000 £’000 1,482 ’0 ’0 £’000 £’000 £’000 1 3 6 5 9 8 5 7 2 2005-06 2005-06 13,219 12,597 £’000 6 2 2 - 2004-05 2004-05 15,050 14,234 13,560 £’000 £’000 tific 109 162 130 543 816 674 2 59 BBSRC Annual Report & Accounts 2005-06 - - - 750 534 162 853 (409) 1,284 £’000 3,104 1,284 1,122 1,705 £’000 1,399 £’000 3,104 2,251 £’000 3,582 3,582 5,827 £’000 (2,567) (5,020) (3,417) 30,856 30,856 12,976 (12,524) 2004-05 2004-05 2004-05 2004-05 2004-05 - 900 863 500 127 223 223 558 (223) (407) (900) Accounts 2005-06 Accounts 1,363 £’000 1,363 6,005 5,670 £’000 1,236 £’000 £’000 6,005 2,901 3,104 £’000 1,813 2,713 6,449 7,463 £’000 (1,834) (7,339) (3,117) 32,163 31,263 2005-06 2005-06 2005-06 2005-06 2005-06 2005-06 BBSRC Total debtors (see Note 13) Total Other debtors vi) Movement in debtors and receipts for fixed assets vi) Movement in debtors and receipts Fixed asset debtors Purchases of investments Purchases Payments to acquire tangible fixed assets Payments to acquire iv) Third Party Assets: Cash held on behalf of Institutes to cover unforeseen losses Party Assets: Cash held on behalf of Institutes to cover unforeseen iv) Third Payments to acquire fixed assets Payments to acquire Less Held for third parties Less Held for third Add decrease in fixed asset creditors Add decrease At 1 April Inflow Gross At 31 March and payments for fixed assets v) Movement in creditors Grant-in-aid financed capital expenditure (See Note 10) Grant-in-aid financed capital expenditure Barclays Bank plc Barclays HM Paymaster General iii) Breakdown of Balances iii) Breakdown Cash as at 31 March Increase from operating activities from Increase Net cash inflow/(outflow) from operating activities from Net cash inflow/(outflow) movement in net funds ii) Reconciliation of movement in cash to 1,215 Cash as at 1 April Decrease in creditors, excluding those for fixed assets excluding in creditors, Decrease Increase in debtors, excluding those for fixed assets in debtors, excluding those for fixed assets Increase Cash received from sale of fixed assets from Cash received (Decrease)/increase in provision for liabilities and charges in provision (Decrease)/increase Increase in fixed asset debtors Increase Reversal of release of Government Grant Reserve Reversal of release Receipts on disposals of fixed assets (see Note 8) 17. NOTES TO THE CASHFLOW STATEMENT THE CASHFLOW TO NOTES 17. surplus/(deficit) to net cash i) Reconciliation of operating operating activities inflow/(outflow) from Operating surplus/(deficit) and impairment charge Reversal of depreciation 60 BBSRC Annual Report & Accounts 2005-06 rfso oga el 696,023 102,726 58,010 69,769 6 1 1 1 CBEFRS Professor CheryllTickle Professor DouglasKell Professor ChrisGilligan Professor Howard DaltonFRS funded byBBSRC: During theyear, thefollowingmaterialpaymentswithCouncilmembers’organisationstookplaceinrespect ofresearch grants for £2.7M. £2.2M (2004-05:£2.0M).Theincludes£0.9Mowedbythe Medical Research Councilbeingthebalancedueonasaleofland accountsof bodieswithintheboundarysetforwholeofgovernment Debtors includebalanceswithothercentralgovernment of theResearch Councils. Council, NaturalEnvironment Research Council,ParticlePhysicsandAstronomy Research Council,CouncilfortheCentral Laborat Research Council,EconomicandSocialResearch Council,EngineeringandPhysicalSciencesResearch Council,MedicalResearch material transactionswithOSI/DTIandentitiesforwhichisregarded astheparent department, viz.: ArtsandHumaniti For thepurposesofFinancialReportingStandard 8,OSI/DTIare regarded asrelated parties.Duringtheyear, BBSRChashadvar Trade andIndustry(DTI). The BBSRCisaNon-DepartmentalPublicBodysponsored bytheOffice ofScienceandInnovation(OSI)withintheDepartment RELATED PARTY TRANSACTIONS21. The loanfacilitywasfullyrepaid after31March 2006. facility wasatafixedrateofinterest of5.4%. £17.3M. Thedifference in valuesaccommodatedcostsarisingfrom apotentialdefaultincludinginterest andlegalcharges.The Technologies LimitedforthedevelopmentofBabrahamBioPark.BBSRC’s liabilityforthisfacilitywas cappedatamaximumo In 2003,BBSRCprovided aBankGuaranteetoofScotlandcover15-year, £11.5M,loanfacilitytoBabrahamBioscience 20. CONTINGENT LIABILITIES have beenauthorisedasat31March: The majorityofcapitalexpenditure fundedbyBBSRCisoncontractsletsponsored institutes.Thefollowingcapitalcommitme 19. CAPITAL COMMITMENTS 18. FORWARD COMMITMENTS ON APPROVED GRANTS RESEARCH After 2009-10 2009-10 2008-09 2007-08 2005-06 Authorised forcontractstobelet 2006-07 Funding approved inprinciple: - Other - BBSRCcontributiontothePirbrightredevelopment BBSRC BBSRC Accounts 2005-06 Awards £ 2005-06 2005-06 22,812 10,486 37,598 £’000 4,300 115.4 183.9 387.7 17.1 65.9 £M 5.4 - 2004-05 2004-05 10,088 8,127 104.9 341.9 164.6 £’000 1,951 es 11.6 57.4 loan 3.4 £M nts f ious ory - - 61 BBSRC Annual Report & Accounts 2005-06 - - £M 2.5 1.5 14.8 04-05 g the less than ities. to which s activities 3.8 0.2 1.5 1.3 0.8 £M 05-06 Accounts 2005-06 Accounts £M 4.8 0.3 - - 4.6 0.4 0.81.2 0.7 - - - - 12.9 BBSRC 04-05 £M 0.2 0.1 1.8 3.8 4.1 0.8 0.3 11.1 (including loans) In Year 05-06 £M 6.2 4.2 - 0.1 - 10.8 5.7 17.4 12.7 10.3 17.9 15.1 89.5 04-05 Grants Debtors Major Provision (See Note 4) (See Note 13) (See Note 15) £M 3.0 7.2 7.1 20.2 15.4 11.9 21.8 18.0 05-06 23. POST BALANCE SHEET EVENTS BALANCE POST 23. Nil. 22. DERIVATIVES AND OTHER FINANCIAL INSTRUMENTS FINANCIAL AND OTHER 22. DERIVATIVES which financial instruments have had durin of the role disclosure requires FRS 13, Derivatives and Other Financial Instruments, *Institutes occupying BBSRC owned estate at peppercorn rents. *Institutes occupying BBSRC owned estate at of it activities. Because of the non-trading nature or changing the risks an entity faces in undertaking its period in creating of financial risk faced by business BBSRC is not exposed to the degree financed, and the way in which government bodies are or changing risk as would be typical of the listed companies in creating financial instruments play no role entities. Moreover, surplus funds and financial assets and liabilities are or invest powers to borrow FRS 13 mainly applies. BBSRC has very limited its activ not held to change the risks facing the Council in undertaking generated by day-to-day operational activities and are Liquidity risk as Grant-in- voted annually by Parliament, and administered financed by resources are requirements resource net revenue BBSRC’s exposed to largely is. BBSRC is not therefore of Science and Innovation, just as its capital expenditure the Office aid through significant liquidity risks. risk Interest-rate described in Note 20. rate risk is to interest only exposure BBSRC’s risk currency Foreign at expenditure currency income is nil and foreign currency risk is insignificant. Foreign currency to foreign exposure BBSRC’s is also negligible. 0.1 per cent of total expenditure The following Council members held positions on the Governing Bodies of sponsored research institutes: research positions on the Governing Council members held The following Bodies of sponsored Chris Gilligan Professor Quintin McKellar Professor Cheryll TickleProfessor CBE FRS and Committees can be found at www.bbsrc.ac.uk/about/gov/ for Council, Boards Registers of interest Roslin Institute Institute for Animal Health Institute Silsoe Research Institute for Animal Health* Babraham Institute* Institute of Food Research* Institute of Grassland and Research* Environmental John Innes Centre Rothamsted Institute Institute* Silsoe Research Total 104.6 Roslin Institute* 62 BBSRC Annual Report & Accounts 2005-06 factors forthestartandendofperiod. paid bytheemployee(includingvalueofanybenefitstransferred from anotherpensionschemeorarrangement)andusescomm This reflects theincrease inCETVeffectively fundedbytheemployer. Ittakesaccountoftheincrease inaccruedpensiondue The real increase inthevalueofCETV additional pensionbenefitaccruedtothememberasaresult oftheirpurchasing additionalyearsofpensionserviceinthesch and forwhichtheCSVote hasreceived atransferpaymentcommensuratewiththeadditionalpensionliabilitiesbeingassumed.T value ofanypensionbenefitinanotherschemeorarrangementwhichtheindividual hastransferred totheResearch Councils'p scheme, notjusttheirserviceinaseniorcapacitytowhichdisclosure applies.TheCETVfigures, andfrom 2003-04the otherp scheme. Thepensionfigures shownrelate tothebenefitsthatindividualhasaccruedasaconsequenceoftheirtotalmember payment madebyapensionschemeorarrangementwhenthememberleaves aschemeandchoosestotransferthebenefitsaccruedin point intime.Thebenefitsvaluedare the member'saccruedbenefitsandanycontingentspouse'spensionpayablefrom theschem A CashEquivalentTransfer Value (CETV)istheactuariallyassessedcapitalisedvalueofpensionschemebenefitsaccruedby The CashEquivalentTransfer Value (CETV) The monetaryvalueofbenefitsinkindcoversanyprovided bytheemployerandtreated byHMRevenueandCustomsasa Benefits inkind performance ofanindividual’s duties. bonuses; over-time; allowancesandanyex-gratiapayments.Itdoesnotincludeamountswhichare areimbursement ofexpensesdi Salary andallowances,includingbonus,coversbothpensionablenon-pensionableamountsincludes:gross salaries;perfo Salary andallowances,includingbonus Definition oftermsusedintheRemunerationReport Dated 27November2001 S Speed Signed forandonbehalfoftheSecretary ofStateforTrade andIndustry Except where agreed otherwisewithHMTreasury, inwhichcasetheexceptionshall bedescribedinthenotestoaccounts. accounts forthefinancialyearended31March 2002andsubsequentfinancialyearsinaccordance with: affairs asattheyear-end. Subjecttothisrequirement theBiotechnologyandBiologicalSciencesResearch Councilshallprepa The annualaccountsshallgiveatrueandfairviewoftheincomeexpenditure cashflowsforthefinancialyear, andthest Technology Act1965,hereby givesthefollowingDirection: The Secretary ofStateforTrade andIndustrywiththeapproval oftheTreasury, inpursuanceofSection2(2)theScience an Accounts direction given by the Secretary of State for Trade and Industry BBSRC BBSRC . anyotherspecificdisclosures whichmayberequired bytheSecretary ofState; c. otherguidance whichtheTreasury mayissuefrom timetoinrespect ofaccountswhere therequirement isto b. ExecutiveNon-DepartmentalPublicBodiesAnnualReportsandAccountsGuidancepublishedbyHMTreasury a. give atrueandfairviewofthefinancialstatements; and asamendedfrom timeto Accounts 2005-06 on behalfoftheController ofHerMajesty’s StationeryOffice Printed intheUKforTheStationery Office Limited 07/06, 5378897 eme attheirowncost. to inflation,contributions ension details,includethe amemberatparticular ension arrangements ship ofthepension hey alsoincludeany rmance payor e. ACETVisa on marketvaluation rectly incurred inthe taxable emolument. theirformer ate of d re