BBSRC Business Summer 2018 Introduction
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Pooled CRISPR-Activation Screening Coupled with Single-Cell RNA-Seq in Mouse Embryonic Stem Cells
ll OPEN ACCESS Protocol Pooled CRISPR-activation screening coupled with single-cell RNA-seq in mouse embryonic stem cells Celia Alda-Catalinas, Melanie A. Eckersley-Maslin, Wolf Reik celia.x.aldacatalinas@gsk. com (C.A.-C.) [email protected]. uk (W.R.) Highlights Protocol for CRISPRa screens with single- cell readout to interrogate gene function Detailed description of CRISPRa screening procedures in mouse embryonic stem cells Detailed steps on how to construct derived single-cell sgRNA amplicon libraries CRISPR/Cas9 screens are a powerful approach to identify key regulators of biological processes. By combining pooled CRISPR/Cas9 screening with a single-cell RNA-sequencing readout, individual perturbations can be assessed in parallel both comprehensively and at scale. Importantly, this allows gene function and regulation to be interrogated at a cellular level in an unbiased manner. Here, we present a protocol to perform pooled CRISPR-activation screens in mouse embryonic stem cells using 103 Genomics scRNA-seq as a readout. Alda-Catalinas et al., STAR Protocols 2, 100426 June 18, 2021 ª 2021 The Authors. https://doi.org/10.1016/ j.xpro.2021.100426 ll OPEN ACCESS Protocol Pooled CRISPR-activation screening coupled with single-cell RNA-seq in mouse embryonic stem cells Celia Alda-Catalinas,1,4,7,* Melanie A. Eckersley-Maslin,1,5,6 and Wolf Reik1,2,3,8,* 1Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK 2Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK 3Centre for Trophoblast Research, University of -
Mothers in Science
The aim of this book is to illustrate, graphically, that it is perfectly possible to combine a successful and fulfilling career in research science with motherhood, and that there are no rules about how to do this. On each page you will find a timeline showing on one side, the career path of a research group leader in academic science, and on the other side, important events in her family life. Each contributor has also provided a brief text about their research and about how they have combined their career and family commitments. This project was funded by a Rosalind Franklin Award from the Royal Society 1 Foreword It is well known that women are under-represented in careers in These rules are part of a much wider mythology among scientists of science. In academia, considerable attention has been focused on the both genders at the PhD and post-doctoral stages in their careers. paucity of women at lecturer level, and the even more lamentable The myths bubble up from the combination of two aspects of the state of affairs at more senior levels. The academic career path has academic science environment. First, a quick look at the numbers a long apprenticeship. Typically there is an undergraduate degree, immediately shows that there are far fewer lectureship positions followed by a PhD, then some post-doctoral research contracts and than qualified candidates to fill them. Second, the mentors of early research fellowships, and then finally a more stable lectureship or career researchers are academic scientists who have successfully permanent research leader position, with promotion on up the made the transition to lectureships and beyond. -
Female Fellows of the Royal Society
Female Fellows of the Royal Society Professor Jan Anderson FRS [1996] Professor Ruth Lynden-Bell FRS [2006] Professor Judith Armitage FRS [2013] Dr Mary Lyon FRS [1973] Professor Frances Ashcroft FMedSci FRS [1999] Professor Georgina Mace CBE FRS [2002] Professor Gillian Bates FMedSci FRS [2007] Professor Trudy Mackay FRS [2006] Professor Jean Beggs CBE FRS [1998] Professor Enid MacRobbie FRS [1991] Dame Jocelyn Bell Burnell DBE FRS [2003] Dr Philippa Marrack FMedSci FRS [1997] Dame Valerie Beral DBE FMedSci FRS [2006] Professor Dusa McDuff FRS [1994] Dr Mariann Bienz FMedSci FRS [2003] Professor Angela McLean FRS [2009] Professor Elizabeth Blackburn AC FRS [1992] Professor Anne Mills FMedSci FRS [2013] Professor Andrea Brand FMedSci FRS [2010] Professor Brenda Milner CC FRS [1979] Professor Eleanor Burbidge FRS [1964] Dr Anne O'Garra FMedSci FRS [2008] Professor Eleanor Campbell FRS [2010] Dame Bridget Ogilvie AC DBE FMedSci FRS [2003] Professor Doreen Cantrell FMedSci FRS [2011] Baroness Onora O'Neill * CBE FBA FMedSci FRS [2007] Professor Lorna Casselton CBE FRS [1999] Dame Linda Partridge DBE FMedSci FRS [1996] Professor Deborah Charlesworth FRS [2005] Dr Barbara Pearse FRS [1988] Professor Jennifer Clack FRS [2009] Professor Fiona Powrie FRS [2011] Professor Nicola Clayton FRS [2010] Professor Susan Rees FRS [2002] Professor Suzanne Cory AC FRS [1992] Professor Daniela Rhodes FRS [2007] Dame Kay Davies DBE FMedSci FRS [2003] Professor Elizabeth Robertson FRS [2003] Professor Caroline Dean OBE FRS [2004] Dame Carol Robinson DBE FMedSci -
The Oxford – Cambridge Arc Home of the New Innovation Economy
Economic Vision: The Oxford – Cambridge Arc Home of the New Innovation Economy April 2019 Contents 1 Introduction 3 2 The Economic Vision 8 3 The New Innovation Economy: Sectors 11 4 The Innovation & Growth Network 24 5 Achieving Ambitions 29 6 Conclusion: Critical Mass 35 | Introduction 1 Introduction 1.1 This vision’s purpose The purpose of the Economic Vision is to explain the Oxford - Cambridge Arc’s unified proposition as a globally leading innovation and growth catalyst. The Arc offers access to each of the critical ingredients for business and innovation-led growth. This collective offer represents a powerful and coherent expression of the region’s current assets and future potential. This Economic Vision for the Arc sets out an ambition and series of proposals designed to unlock the economic potential of the region and deliver transformative growth for the UK between now and 2050. It provides a vision for how the Arc can better connect its unique and world-leading assets to become truly globally competitive in frontier markets, both for business investment and for top talent. With a bolder brand and stronger international presence the Arc can continue to lead the whole of the UK to the forefront of global innovation excellence in the coming years and decades. 3 | Introduction This Economic Vision is built upon the foundation of This Economic Vision has been developed in the four local industrial strategies which currently partnership with the three LEPs and the Combined demarcate the Arc’s geographic area. These have Authority, who have been given a mandate by Central been prepared by the Oxfordshire (OxLEP), South Government to drive forwards the Economic Vision for East Midlands (SEMLEP) and Buckinghamshire the Arc: Thames Valley (BTVLEP) Local Enterprise Partnerships, as well as the Cambridgeshire & Peterborough Mayoral Combined Authority (CPCA). -
Part I Officers in Institutions Placed Under the Supervision of the General Board
2 OFFICERS NUMBER–MICHAELMAS TERM 2009 [SPECIAL NO.7 PART I Chancellor: H.R.H. The Prince PHILIP, Duke of Edinburgh, T Vice-Chancellor: 2003, Prof. ALISON FETTES RICHARD, N, 2010 Deputy Vice-Chancellors for 2009–2010: Dame SANDRA DAWSON, SID,ATHENE DONALD, R,GORDON JOHNSON, W,STUART LAING, CC,DAVID DUNCAN ROBINSON, M,JEREMY KEITH MORRIS SANDERS, SE, SARAH LAETITIA SQUIRE, HH, the Pro-Vice-Chancellors Pro-Vice-Chancellors: 2004, ANDREW DAVID CLIFF, CHR, 31 Dec. 2009 2004, IAN MALCOLM LESLIE, CHR, 31 Dec. 2009 2008, JOHN MARTIN RALLISON, T, 30 Sept. 2011 2004, KATHARINE BRIDGET PRETTY, HO, 31 Dec. 2009 2009, STEPHEN JOHN YOUNG, EM, 31 July 2012 High Steward: 2001, Dame BRIDGET OGILVIE, G Deputy High Steward: 2009, ANNE MARY LONSDALE, NH Commissary: 2002, The Rt Hon. Lord MACKAY OF CLASHFERN, T Proctors for 2009–2010: JEREMY LLOYD CADDICK, EM LINDSAY ANNE YATES, JN Deputy Proctors for MARGARET ANN GUITE, G 2009–2010: PAUL DUNCAN BEATTIE, CC Orator: 2008, RUPERT THOMPSON, SE Registrary: 2007, JONATHAN WILLIAM NICHOLLS, EM Librarian: 2009, ANNE JARVIS, W Acting Deputy Librarian: 2009, SUSANNE MEHRER Director of the Fitzwilliam Museum and Marlay Curator: 2008, TIMOTHY FAULKNER POTTS, CL Director of Development and Alumni Relations: 2002, PETER LAWSON AGAR, SE Esquire Bedells: 2003, NICOLA HARDY, JE 2009, ROGER DERRICK GREEVES, CL University Advocate: 2004, PHILIPPA JANE ROGERSON, CAI, 2010 Deputy University Advocates: 2007, ROSAMUND ELLEN THORNTON, EM, 2010 2006, CHRISTOPHER FORBES FORSYTH, R, 2010 OFFICERS IN INSTITUTIONS PLACED UNDER THE SUPERVISION OF THE GENERAL BOARD PROFESSORS Accounting 2003 GEOFFREY MEEKS, DAR Active Tectonics 2002 JAMES ANTHONY JACKSON, Q Aeronautical Engineering, Francis Mond 1996 WILLIAM NICHOLAS DAWES, CHU Aerothermal Technology 2000 HOWARD PETER HODSON, G Algebra 2003 JAN SAXL, CAI Algebraic Geometry (2000) 2000 NICHOLAS IAN SHEPHERD-BARRON, T Algebraic Geometry (2001) 2001 PELHAM MARK HEDLEY WILSON, T American History, Paul Mellon 1992 ANTHONY JOHN BADGER, CL American History and Institutions, Pitt 2009 NANCY A. -
Minutes of the Proceedings
MINUTES OF THE PROCEEDINGS at the Thirty‐sixth Meeting of the COUNCIL of the IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE The Thirty‐sixth Meeting of the Council was held in the Council Room, 170 Queen’s Gate, South Kensington Campus, Imperial College London, at 10:00 a.m. on Friday, 16th May 2014, when there were present: The Baroness Manningham‐Buller (Chair), Professor A. Anandalingam, Mr. C. Brinsmead, Dame Ruth Carnall, Mrs. P. Couttie, Professor M.J. Dallman, Mr. P. Dilley, Mr. D. Goldsmith, Professor N. Gooderham, Professor Dame Julia Higgins, Professor D.P.A. Kelleher, Ms. J.R. Lomax, Professor J. Magee, Mr. J. Newsum, Mr. S. Newton, Ms. K. Owen, Mr. M. Sanderson, Professor J Stirling, the President & Rector and the Clerk to the Court and Council. Apologies Mr. I. Conn. MINUTES Council – 7th February 2014 1. The Minutes of the thirty‐fifth Meeting of the Council, held on Friday, 7th February 2014, were taken as read, confirmed and signed. CHAIR’S REPORT 2. The Chair advised members that, following his appointment as Chair of the Chelsea and Westminster Hospital NHS Foundation Trust, Sir Thomas Hughes‐Hallett had resigned as a co‐opted member of the Council on 11 February. PRESIDENT & RECTOR’S REPORT 3. The President & Rector reported that this year’s Imperial Festival, held on 9th and 10th May, had received many visitors at the South Kensington campus to enjoy the various demonstrations, talks 1 Council 16th May 2014 and other activities on offer. What had started as a relatively modest pilot project in 2012 to explore how Imperial College London might share its research with more people had now evolved into a large‐scale and prominent annual fixture in the College’s calendar. -
Medical Research Council Annual Report and Accounts 2006/07 HC 93
06/07 Annual Report and Accounts © Crown Copyright 2006 The text in this document (excluding any Royal Arms and departmental logos) may be reproduced free of charge in any format or medium providing that it is reproduced accurately and not used in a misleading context. The material must be acknowledged as Crown copyright and the title of the document specified. Any queries relating to the copyright in this document should be addressed to The Licensing Division, HMSO, St Clements House, 2-16 Colegate, Norwich, NR3 1BQ. Fax: 01603 723000 or e-mail: licensing@cabinet-office.x.gsi.gov.uk 2 MRC Annual Report and Accounts 2006/07 Medical Research Council Annual Report and Accounts 2006/07 Presented to Parliament by the Secretary of State, and by the Comptroller and Auditor General in pursuance of Schedule I, Sections 2(2) and 3(3) of the Science and Technology Act 1965. Sir John Chisholm Chairman Professor Sir Leszek Borysiewicz Deputy Chairman and Chief Executive Ordered by and printed on London: The Stationery Office 6 February 2008 Price: £18.55 HC 93 The Medical Research Council The MRC RCUK The Medical Research Council (MRC) was set up in 1913 to administer Research Councils UK (RCUK) is a partnership of the seven (formerly public funds for medical research. It was incorporated under its eight) UK Research Councils – public bodies funded mainly by the UK present title by Royal Charter in 1920. A supplemental charter was Government via OSI. granted in 1993 describing the MRC’s new mission following the 1993 government white paper on science and technology. -
From the Chair… in This Issue
MARCH 2019 An Hes ‘The Swarm’ Newsletter of West Cornwall Beekeepers Association Secretary: [email protected] www.westcornwallbka.org.uk From the Chair… In this issue: News in Brief Pg 2 Lots going on over the next couple of months in “bee Asian hornet projects Pg 3 world” – apart from delving into the homes of our bees, Bee Health Day Pg 4 and chasing them over the horizon! Prof Pickard is always an entertaining speaker, and he will be talking at CBKA Centenary Pg 5 the CBKA centenary celebrations next week – book What’s On? Pg 6 now! Royal Cornwall Show is almost upon us – an opportunity to enter something to show off your talents – more entries always welcome! Don’t forget the Bee Health day at the University of Exeter, Penryn Campus- still places left for an opportunity to catch up on bee diseases, whatever type of bee or hive you Save the Date! favour... Saturday 18th May 2019 And congratulations to Pete Kennedy and the team at CBKA Centenary Celebrations the University of Exeter. I’m particularly interested in the project looking at the diet of the Asian Hornet - may Thursday 6th, Friday 7th & just go to prove that honey bees are not the only Saturday 8th June 2019 delicacy.... The Royal Cornwall Show nd Kate Bowyer Saturday 22 June 2019 Bee Health Day “I see the moon like a clipped Bee tes… piece of silver. Like gilded Bees Quo ♯21 the stars cluster around her” - Oscar Wilde 2 AN HES MARCH 2019 News Bees and Equipment for Sale: Bee Health Day 2019 Secure yourself a place at this year’s Bee A 12 month old poly dome hive with colony of bees, Health Day, which takes place at the one full super & one nearly full super are all for sale. -
Michael John Owen Wakelam 1955–2020
obituary Michael John Owen Wakelam 1955–2020 We have lost a distinguished biochemist who dedicated his career to the study of phosphatidylinositol signalling in metabolic regulation and to the advancement of lipidomics. ichael John Owen Wakelam passed away on 31 March, 2020 at the Mage of 64, much too early. He became known to colleagues and friends as a scientist highly regarded for his research. He was honoured in 2018 with the Morton Lectureship of the Biochemical Society and was elected a fellow of the Royal Society of Biology. In 2019, he was elected a member of the Academia Europaea. Academic career It was not by chance that Michael turned his focus to phosphatidylinositols (PIs) and lipid signalling. He was a student and later a professor at the University of Birmingham at a time when Britain was the world’s hub of pioneering phospholipid research, such as that by J. N. Hawthorne and Bob Michell on PI in Birmingham. Bob Michell inspired Michael extraordinarily, and they even published a joint review. Subsequently, Michael moved to Cambridge to serve as the director of the Babraham Institute, where Credit: Babraham Institute Rex Dawson and Robin Irvine studied phospholipids, particularly PI metabolism and signalling. A joint publication by Michael and Irvine appeared as well. the Babraham Institute, and he received an the Keystone Symposia on Molecular and Certainly, Michael’s scientific engagement honorary professorship in lipid signalling at Cellular Biology. can be seen in the tradition of these eminent the University of Cambridge Clinical School. phospholipid scientists. In addition, he was an honorary professor Lipid signalling and metabolism Michael’s career path is impressive. -
Guidance for Applicants
Guidance for applicants The British Academy, Royal Academy of Engineering and A full list of the disciplines covered by the Academies can the Royal Society are three of five Designated Competent be found in the ‘Guidance on Policy for UK visas under Tier Bodies (DCBs) appointed by the Home Office to assess 1 (Exceptional Talent)’ document available on the Home applications for the Research and Innovation Talent Visa Office website. under the Home Office Tier 1 (Exceptional Talent) Visa route. Holders of a Research and Innovation Talent Visa that were As DCBs, the Academies are responsible for considering endorsed through Exceptional Talent are eligible to apply whether an individual who makes an application for settlement (Indefinite Leave to Remain) after three years. is demonstrably ‘exceptionally talented’ or has Holders endorsed through Exceptional Promise are eligible ‘exceptional promise’. after five years. Tier 1 (Exceptional Talent) is subject to a limit of 2,000 visas per year (beginning on 6 April one year and ending on 5 April the following year). The Academies assess applications in the following areas and are allocated a minumum number of endorsements by the Home Office from the total annual pool. • The British Academy – for humanities and social sciences (150 endorsements); • The Royal Society – for natural sciences and medical science research (250 endorsements); • The Royal Academy of Engineering – for engineering (150 endorsements). TIER 1 APPLICATION GUIDANCE 1 Overview of the application process The application for a Research & Innovation Talent visa Should the decision be upheld then the process ends here. (Tier 1 Exceptional Talent) is in two stages: You can still apply via another visa route or re-apply to this route with revised supporting evidence. -
Quadram Institute Newsletter
Autumn 2019 Welcome to the newsle�er of the Quadram Ins�tute. This issue highlights recent research breakthroughs at the We con�nue to build our team and are pleased to welcome Quadram Ins�tute (QI) that could have posi�ve impacts on Professor Cynthia Whitchurch to the QI. Cynthia is se�ng public health. Working with clinicians our researchers have up a research group inves�ga�ng bacterial lifestyles, and shown how the latest sequencing technologies can aid in how these make them more infec�ous or resistant to diagnos�cs and surveillance. Coupling these techniques an�microbials. Cynthia joins us from the ithree ins�tute at with ‘Big Data’ analy�cal approaches will be vital to the University of Technology Sydney. Her research led to addressing 21st century popula�on health challenges, and the discovery that extracellular DNA is required for biofilm the QI aims to be a leader in this area. development. Big Data in the NHS was the topic of a roundtable We con�nue to welcome visitors to our new building to discussion I a�ended with Patricia Hart at the policy share our vision to understand how food and microbes development think tank Reform. This roundtable was interact to promote health and prevent disease. In June, we sponsored by QI and explored how universi�es and industry had the honour of hos�ng His Excellency Simon Smits, can work with government to realise poten�al applica�ons Ambassador of the Netherlands to the UK. The Ambassador of Big Data. The event was chaired by Baroness Blackwood, visited the Norwich Research Park as part of an Parliamentary Under-Secretary of State, Department of interna�onal trade delega�on to East Anglia to learn about Health and Social Care (DHSC) and included senior the region’s world-leading life sciences research and trade policy-makers, public service prac��oners, academics and opportuni�es. -
Liquid Crystalline Polymers: Second Edition A
Cambridge University Press 978-0-521-58001-4 - Liquid Crystalline Polymers: Second Edition A. M. Donald, A. H. Windle, and S. Hanna Frontmatter More information LIQUID CRYSTALLINE POLYMERS SECOND EDITION The new edition of this authoritative guide on liquid crystalline polymer (LCP) science has been produced in response to the wealth of new material recently generated in the field. It takes the reader through the theoretical underpinnings to real-world applications of LCP technology in a logical, well-integrated manner. A chapter on liquid crystalline biopolymers has been introduced, whilst the in-depth discussion on applications describes not only maturing fields of high strength structural LCPs, but also a detailed analysis of the developing area of functional materials. The in-depth coverage and detailed glossary establish this as an indispensable text for graduate students and researchers in the polymer field, as well as being of interest to those working in chemistry, physics and materials science. A THENE D ONALD became Professor of Experimental Physics at the University of Cambridge in 1998 after many years as a lecturer and then reader. She was elected as Fellow of the Royal Society in 1999. She is the author of over 200 papers in the general field of soft matter physics, with interests spanning from synthetic to biologically relevant polymers. A LAN W INDLE is Professor of Materials Science at the University of Cambridge, Fellow of Trinity College, Cambridge, and Fellow of the Royal Society. He is the author of around 200 papers on polymer structure, LCPs and carbon nanotubes. He has previously held positions as head of the Materials Science department in Cambridge and director of the Cambridge MIT Institute.