We izm a nn In s t it u t e

1 9 4

9

-

2

0

1

9

L

E

A

R

S

I

t

o

v

o

h

e R

Facts and Figures The Weizmann Institute of Science at a glance 2019-2020 7 decades of scientific discovery The Weizmann Institute of Science opened in 1949 with 44 scientists,17administrators, and 69 technicians

In 1941, Dr. established the first pharmaceutical company in Our Israel, Palestine Pharmaceutical Products, Ltd. Roots

For over 80 years—first as the Daniel Sieff Research Institute, then renamed in honor of Dr. Chaim Weizmann, a Zionist pioneer who served as the first President of both the Institute and the newborn State of Israel—the Weizmann Institute of Science has WEIZAC, the first computer contributed thousands of landmark discoveries. in Israel and one of the first The Weizmann Institute of Science was Dr. Weizmann developed the process for producing acetone through bacterial the first to conduct cancer research in the world, was designed fermentation, which was of great importance to the British during . He in Israel and the first to buildparticle and built at the Weizmann worked with Lord Arthur James Balfour to write the Balfour Declaration in support of accelerators. Institute in 1954. the establishment of the State of Israel, and met with U.S. President Harry Truman. Dr. Weizmann’s residence, on the Institute campus, is now a national museum. Discover the Weizmann Institute of Science. One of the world’s top-ranking centers of basic research, the Weizmann Institute of Science is dedicated to curiosity-driven

science. The Institute’s mission is to increase knowledge about our natural world, for Faculty and Staff the benefit of all humanity. 2,600

At the Weizmann Institute, exceptionally talented people are given precious gift: the freedom to follow their dreams. Laboratories 280 The Weizmann Institute sets the global standard for excellence in scientific achievement. This year, the Weizmann Faculty of Biology Institute celebrates its 70th anniversary, Biological Regulation Centers and Institutes an apt time to look back in pride, and look Immunology 90 Molecular Cell Biology forward to many more years of success. Faculty of Chemistry Neurobiology Prof. , President Chemical and Biological Physics Life Sciences Core Facilities 5 Faculties Earth and Planetary Sciences

Materials and Interfaces Faculty of Biochemistry Departments Organic Chemistry Biomolecular Sciences 18 Structural Biology Molecular Genetics Chemical Research Support Plant and Environmental Sciences Life Sciences Core Facilities

Faculty of Physics Faculty of Mathematics and Computer Science Condensed Matter Physics Computer Science and Applied Mathematics Particle Physics and Astrophysics Mathematics Please join us on our journey of scientific Physics of Complex Systems discovery, as we continue to reveal Physics Core Facilities Department of Science Teaching important knowledge and offer insights Research that provide real benefit to humanity, I look Scientific Archaeology Unit forward to working with you all. Prof. Alon Chen, President-elect Average temperature July/Aug: 22-32 C (72-90 F) Jan/Feb: 8-19 C (47-65 F) Tel Aviv 27 km (17 miles) Buildings designated for Jerusalem (33 miles) historical24 preservation 53 km

200 Scientists live on campus Students and postdocs live in campus housing Buildings 590 The proximity of faculty on243 campus housing to the research labs Campus and childcare facilities helps Weizmann Institute scientists enjoy Located in the city of Rehovot, the Weizmann Institute is a green oasis dotted with a full family life and a productive research career. outdoor sculptures and orange groves—a perfect environment for creative discourse, There are 170 children of and a place that scientists, staff, and their families are proud to call home. Artesian wells feed into systems Weizmann scientists and 4of pipes: potable water for drinking2 and Dr. Weizmann envisioned a campus in which scientists would work in a pristine, brackish water for irrigation staff—aged four months to natural environment. Here, they interact with one another in labs and outdoors, in Trees of five years—in the Institute’s 5,000different species110 2 a place where scientists can cross disciplinary boundaries with ease, and thereby Campus area (280 acres) on-campus childcare facilities. advance fresh and innovative ideas to further scientific research. 1.1 km There are about active competitive grants1,200 funding Weizmann research at any given time

Since 2011, Weizmann Institute success rate for European Research scientists have been awarded million Council50% Starting Grants for the years 2009-2018. in competitive grants$760 The average success rate in Europe is 12%. in European Research Council #1 grants in 2018, as a percentage of total principal investigators

on the 2017 Nature Index measuring how effectively #6 basic research translates into applications

in the 2018 Leiden University #9 international ranking of Profs. Adi Kimchi and Dan Prof. (pictured at right) is the co-inventor, with Prof. Ruth Arnon and scientific research impact 1 Nobel Prize Yakir were awarded the 2019 Dr. Devorah Teitelbaum of the blockbuster multiple sclerosis drug Copaxone®. His 37 Israel Prizes Israel Prize. research also underpins three cancer drugs, Erbitux®, Portrazza®, and Vectibix®. 3 Turing Awards Japan Prizes Prof. Kimchi was recognized For deciphering the structure and mechanism of ribosomes, the Weizmann Institute’s 2 for her trailblazing work Wolf Prizes Prof. Ada Yonath won the 2009 Nobel Prize in Chemistry. 7 which clarified why cells live or die, and for her discovery of Profs. Moshe Oren and Varda Rotter revealed the importance of the major tumor a tumor suppressor gene. suppressor protein, p53. Their seminal work involved cloning and characterizing the Prof. Yakir was recognized for gene that encodes the p53 protein, which has since become the most-studied protein his groundbreaking insights on in cancer research. Between 2009 and 2018, Weizmann scientists had a nearly 55% success rate in the impact of semi-arid forests The RSA encryption algorithms that allow secure payments over the Internet, and obtaining scientific grants. on the global climate. safeguard many other computer-based transactions, were co-invented by the Weizmann Submissions Institute's Prof. Adi Shamir. Grants received Excellence

Africa

2

10 10 South America South

14 14 North America North

151 151 Asia

375 More than principal investigators 150 106 Israel recruited since 2006 Europe 92

Dr. Elena Meirzadeh, a recent 375 Postdoctoral fellows recipient of the women's from 38 countries postdoc award, is currently People conducting her postdoctoral The most valuable asset of the Weizmann Institute of Science is its people. The research at Columbia Institute recruits some of the world’s most outstanding investigators in the natural and University in New York. exact sciences, and then invests in them, supporting their curiosity and new research 280 directions that lead to remarkable breakthroughs. Research groups A full 72% of Women in Every year, the Weizmann Institute hires approximately 12 new scientists, based solely Science fellowship recipients have returned to Israel for jobs on excellence in their respective fields rather than on a department-specific quota. Since 2007, female PhD in academic research, while Weizmann scientists are the recipients of the world's most prestigious research awards graduates throughout136 Israel have others have received jobs in and serve as reviewers and editors of top scientific journals. received fellowships as part of the Israel National Postdoctoral the high-tech and biotech Award Program for Advancing industries. A dozen recipients 190 Staff scientists Women in Science. have joined the Weizmann Institute faculty.

Pictured: Prof. Elisabetta Boaretto, Scientific Archaeology Unit USA Czech Germany France Scotland Italy Canada International Brazil Japan Netherlands Russia Australia International collaborations are the lifeblood of modern science—partnerships that China Spain Percentage of publications enrich research at the Weizmann Institute of Science and beyond. Such collaborations Sweden written in collaboration with Poland include peer-to-peer initiatives, joint grants, and formal institutional agreements. Australia at least one scientist from the Brazil Sweden Scotland countries indicated Czech Republic Spain Collaborations 0 5 10 15 20 25 30 35 40 joint grants currently link Weizmann Institute labs to leading research China 370 Visiting scientists institutions all over the world. Russia came840 to campus in 2018

Netherland Weizmann scientists collaborate with colleagues at: For more than a decade, Japan the Making Connections UK Harvard Medical School (USA) Canada Program has brought Memorial Sloan Kettering Cancer Center (USA) Italy together Weizmann The Max Planck Society (Germany) scientists with colleagues at University of Oxford (UK) England prestigious UK institutions The University of Science and Technology of China France to work on joint research Massachusetts Institute of Technology (USA) projects. The program is École Polytechnique Fédérale de Lausanne (EPFL) () Germany funded by generous UK University of Michigan (USA) USA donors and has served as RIKEN Brain Science Institute (Japan) the inspiration for similar Stanford University (USA) collaborative programs in Pasteur Institute (France) Australia and France. The Garvan Institute of Medical Research (Australia) McGill University (Canada) The David Lopatie Conference Centre and the Dimitris N. Chorafas University of São Paulo (Brazil) Institute for Scientific Exchangehost and support and many more... over international conferences per year, solidifying the Institute's role as 70a global hub of scientific research. Weizmann research has been cited over times by other researchers 2 million

Weizmann scientists have published over research studies in professional journals 54,000 Over the past five years, Institute scientists have published an average of1,700 studies per year The Weizmann Institute of Science was recently ranked 25% of Israel’s PhDs #2 worldwide in research in science and math were trained at quality by the journal Nature, the Weizmann Institute reinforcing its reputation as a Members of the Weizmann Institute faculty publish highly influential research in compact but powerful engine the world’s top scientific journals. Trailblazing discoveries made in Institute labs drive of scientific research. the discussion at international conferences and inspire fruitful collaboration with colleagues in Israel and abroad. Impact billion in global sales of products $36.5based on Weizmann research More than companies have In 1959, the Weizmann Institute been established60 around Weizmann established Yeda R&D Co. It was the technologies since 2004. first technology transfer organization in Israel, and one of the first in the world.

Bio-Technology General, established by Yeda in 1980, new patents were awarded in 2018 was Israel's first biotech 166 start-up company that Top-selling drugs to emerge emerged from academia. from Weizmann labs: ® Among other contributions, • Copaxone ® it produced bovine growth • Rebif ® hormone (bGH) to increase • Erbitux ® the milk output of cows. • Humira • Enbrel® Applications • Tookad® Prof. Zelig Eshhar is a Breakthroughs in basic science made at the Weizmann Institute have resulted in a wide pioneer of CAR T-cell range of patented technologies that make the world a better, safer, and healthier place. therapy, which involves Institute research has led to key insights that have expanded the body of knowledge engineering cancer patients’ across the scientific spectrum. immune cells and reinjecting them into the body so they Among other recent bench-to-bedside success stories, Profs. Avigdor Scherz and can better fight off the Yoram Salomon devised a treatment for prostate cancer, called Vascular Targeted World-changing technologies: cancer. Clinical trials have ® • amniocentesis for prenatal testing Photodynamic Therapy in concert with TOOKAD Soluble (TS-VTP), which eradicates shown a 94% success rate. • RSA Internet security algorithm cancerous growth while preserving function. The therapy has shown dramatic results • biomolecular computers in clinical trials, and is being tested for other cancer types. • vaccine for hepatitis B • methods to battle crop-destroying parasitic weeds 2019/20 Total Operating Budget: 1,585 MNIS

1% 1% Other Administration 1% 1% Infrastructure and maintenance International departments 8% 1% Budget Related companies Scholarships

43% Salaries and related expenses 44% Scientific Expenses 2011-2020 (MNIS) Scientific support

695 694 654 650 646 World-leading science 538 depends on top-of-the-line 493 458 scientific infrastructure. 421 Core facilities available to Operating Budget (MNIS) The operating budget of the Weizmann Institute of Science is Weizmann scientists include around 1.5 billion NIS per year. A third of this funding comes Increase of 55% advanced microscopy and 1,528 1,576 1,556 1,581 1,585 from the government of Israel. The rest of the Institute’s income 1,411 imaging, pre-clinical testing, 1,273 1,327 is generated through research discoveries, competitive grants, 1,088 1,145 genomic and protein profiling, private philanthropy, and scientific services offered by Weizmann computational services, and core facilities to academic and commercial partners. equipment for experimental physics. Scientific discoveries generate significant income from licensing 2011/12 2012/13 2013/14 2014/15 2015/16 2016/17 2017/18 2018/19 2019/20 agreements made through Yeda R&D, the Institute’s technology transfer arm. The 55% increase in scientific expenditures since 2011/2012 is due, in part, to the rise in volume and cost of state-of-the-art instrumentation, which ensures that Weizmann 2010/11 2011/12 2012/13 2013/14 2014/15 2015/16 2016/17 2017/18 2018/19 2019/20 Institute scientists are able to conduct research at the highest level. Thanks to next-generation imaging technologies in the life sciences, one year of raw experimental data can use 500 terra-bytes Over labs involved in cancer research are supported of storage. This precious data will be stored in state-of-the art computer farms throughout the Weizmann Institute. by the60 Moross Integrated Cancer Center.

The Artificial Intelligence Center for Scientific Exploration will drive the donor-supported understanding of AI and make high- 90centers and institutes performance computing and machine- learning tools available across a vast array of scientific areas. Envisioned as Israel's most advanced computing infrastructure entity, it will provide a necessary solution to the challenge of The future André Deloro Building will house the Tom and Mary Beck Center for “Big Data”. Advanced and Intelligent Materials, where scientists will conduct research on Professorial Chairs: materials with applications in medicine and medical devices, aerospace and defense, Prof. Ido Amit of the energy and energy sources and beyond. Department of Immunology is the first incumbent of the At the Moross Integrated Cancer Center, Weizmann Institute scientists are Eden and Steven Romick harnessing the power of basic research to promote cancer prevention, early diagnosis, Professorial Chair. An improved treatment, and ultimately, a cure. infusion of funds to support tenured scientists, fueled by The Nancy and Stephen Grand Israel National Center for Personalized Medicine a personal spark between (G-INCPM) is a national facility that offers state-of-the-art genomics, protein profiling, Flagship scientist and donor, advances drug discovery, bioinformatics, and medicinal chemistry research platforms to science and nourishes the academic, clinical, and commercial clients. careers of Israel's brightest Projects minds. The Azrieli National Institute for Human Brain Imaging and Research is a leading- edge facility whose goal is to generate insights that will lead to improved therapies and cures for brain-related diseases. ULTRASAT's field of view will be250 degrees squared—300 times New larger than the most sensitive UV satellite built to date.

Weight: 160 kg Dimensions: 1.2m x 1.2m x 0.6m Initiatives

ULTRASAT, a new space satellite, will enable scientists to continuously gather data on transient events in space moments after they occur—a massive leap in progress over A wide-ranging initiative the days or weeks it takes current telescopes to do the same. Led by Profs. Eli Waxman in brain science will bring and Avishay Gal-Yam, ULTRASAT will place the Weizmann Institute in a world-leading together the diverse range of position in the study of the most important astrophysics questions of the coming neuroscience research projects decade. underway across campus. In addition, a new state-of- This mini-satellite will carry a telescope designed to observe the Universe as it has the-art facility will serve as never been seen before. Focusing on ultraviolet emissions—a range of light that is the focal point for advancing normally invisible to us—it will continuously monitor swaths of the night sky wider than cutting-edge research in this was ever before possible. realm. alumni since the students establishment7,500 of the Feinberg 1,150 Graduate School

students and postdocs from abroad study425 and work in Weizmann labs.

MSc430 students Postdoctoral375 PhD720 students fellows

A start-up founded by Weizmann alum Aviad A core mission of the Weizmann Institute is to train the next generation of scientific Maizels, PrimeSense, leaders. At the Feinberg Graduate School, a highly select group of students studies in developed a technology that English in one of five research schools, acquiring the skills needed to take the lead at can both see 3D scenery the forefront of science. and analyze it. In 2013, PrimeSense was acquired Supervised by the Institute’s faculty members, Weizmann Institute graduate students by Apple, and its technology make important contributions to research and are highly sought-after for post- has been integrated into the graduate positions in academia and industry. latest iPhone models. The research schools: The Weizmann Alumni André Deloro Research School of Physical Science Organization cultivates Solo Dwek and Maurizio Dwek Research School of Chemical Science personal and professional students in the Rothschild-Weizmann Lorry I. Lokey Research School of Biochemical Science 52 connections among alumni, EKARD Research School of Biological Science program offering non-thesis MSc degrees to practicing science teachers and between alumni and the Moross Research School of Mathematics and Computer Science Israeli high-tech, biotech, Over 300 teachers have and medical sectors. graduated from the program. Students Each year the Science on Tap series brings popular science lectures to Tel Aviv bars 50 Israeli students and350,000 teachers participate in educational programs at the Weizmann Institute each year.

More than students from around 3,400 the globe have participated in the Dr. Bessie F. Lawrence International Summer Science Institute. The Davidson Institute of Science Education’s online activities have reached National centers for science teachers science educators 4 million unique users. established through the Department of are3,700 trained by the Davidson 3.7 Science Teaching: Chemistry; Physics and Institute annually. Earth Sciences; Biology and Environmental For 20 years, the Clore Sciences; and Science and Technology for Garden of Science has served Middle School. as a model for open-air science museums around the Scientific progress and leadership depends on an educated society. world. Following a major renovation funded by the Clore The Davidson Institute of Science Education offers more than70 innovative Israel Foundation, the Garden programs that inspire young people to build science into their future. of Science will be reshaped Science into an ultra-modern hub for The Clore Garden of Science is an outdoor facility designed to give children hands-on science learning. hands-on exposure to the excitement of science. 135,000 visitors explore the Clore

Garden of Science every year. Perach, a national tutorial program founded in 1974 at the Weizmann Institute, has matched The Department of Science Teaching conducts research on science and Literacy mathematics education, provides professional development for teachers, and at-risk children with generates curricula and textbooks for Israeli schools. 50,000 university student mentors. 22,500 Visitors

The Levinson Visitors Center hosts visitors each year 24,000

The Weizmann Archive contains more than historical documents, including letters from and Lord200,000 Arthur James Balfour, and is open to the public The Gershon Kekst International Office serves as a home away from home for visiting international scientists, students, and Weizmann House was designed by famed postdocs. Pictured above, German architect Erich Mendelsohn and built in 1936 scientists and students from China organize the first Visitors are welcome to tour the campus of the Weizmann Institute of Science and Weizmann celebration of the the historic Weizmann House , the former home of Chaim and Vera Weizmann. The Chinese New Year for their Levinson Visitors Center is the gateway to the Institute, giving visitors a window into the friends and colleagues. unique nature of scientific investigation and discovery on campus, and the Weizmann Institute’s central role in Israeli science and technology. Prof. Daniel Zajfman (seated), flanked by his management team, from L to R: Prof. Michal Neeman, MANAGEMENT Shuli Geri, Prof. Mudi Sheves, and Prof. Israel Bar-Joseph. Prof. Daniel Zajfman President

Prof. Michal Neeman Vice President INCOMING MANAGEMENT

Prof. Israel Bar-Joseph Prof. Alon Chen VP, Resource Development and President-elect Public Affairs Prof. Ziv Reich Prof. Mordechai Sheves Vice President-designate VP, Technology Transfer Prof. Roee Ozeri Shulamit Geri VP-designate, Resource VP, Administration and Finance Development and Public Affairs

Prof. Jehuda Reinharz Prof. Irit Sagi Chair, International Board VP-designate, Technology Setting policy, driving progress—the management of the Weizmann Institute is led by Transfer highly experienced senior investigators, together with a robust International Board and a Shimshon Harel Chair, Executive Board global community of supporters who share a vision of science for the benefit of humanity. Prof. Alon Harmelin VP-designate, Administration and Committees around the world represent the Institute’s interests by forging Finance connections with individuals, families, foundations, and the business community, and educating the public about the latest discoveries emerging from Weizmann labs. Leadership Miracles Join us in sometimes occur, working hard but one has to achieve to work terribly hard tomorrow’s for them. miracles....

Dr. Chaim Weizmann Vision American Committee for the European Committee of the Weizmann France Department of Resource A publication of the Department Resource Development Design : dio-olamot Studio Yael Ilan • Eclipse Productions Wikimedia Commons Israel Sun Ltd Weizmann Institute archives Photography : Itai Belson and Ohad Herches of the Weizmann Institute Photagraphy Lab Weizmann Institute of Science Weizmann Institute of Science Development Tel.: 33 1 47 04 33 43 Tel.: 972 8 934 4582 Tel.: 1 800 242 2947 Tel.: 41 44 380 3200 [email protected] resource.development@ [email protected] [email protected] www.weizmann-france.com www.weizmann-usa.org www.weizmann.ac.il/pages/ weizmann.ac.il www.weizmann.ac.il/giving ecwis

Weizmann UK Weizmann Australia Israeli Friends of the Tel.: 44 207 424 6860 Weizmann Institute of Science Tel.: 61 438 778 809 [email protected] [email protected] Tel.: 972 8 934 3890 / 3889 www.weizmann.org.uk www.weizmann.org.au [email protected] www.weizmann.ac.il/Aguda- tHayedidim

Weizmann Canada Tel. (Toronto): 1 416 733 9220 Tel. (Montreal): 1 514 342 0777 Latin American Committee Tel. (Calgary): 1 587 774 7215 for the Weizmann Institute of [email protected] Science www.weizmann.ca Tel.: 972 8 934 2155

[email protected] www.weizmann.ac.il/pages/latin- america