April 2019 Vol. 30 No. 4

This Month’s Highlights 546 LRG1 Promotes Diabetic Kidney Disease Progression by Enhancing TGF-b–Induced UP FRONT MATTERS Angiogenesis Quan Hong, Lu Zhang, Jia Fu, Divya A. Verghese, Kinsuk Chauhan, Girish N. Nadkarni, Zhengzhe Li, Editorials Wenjun Ju, Matthias Kretzler, Guang-Yan Cai, 519 The Other Glucose Transporter, SGLT1 – Also Xiang-Mei Chen, Vivette D. D’Agati, Steven G. Coca, a Potential Trouble Maker in Diabetes? Detlef Schlondorff, John C. He, and Kyung Lee Mattias Carlström See related article by Zhang et al. (pp. 578–593). · 564 .The RNA-Protein Interactome of Differentiated 521 Piecing Together the Risk of Sudden Cardiac Kidney Tubular Epithelial Cells Michael Ignarski, Constantin Rill, Rainer W.J. Kaiser, Death on Dialysis Eric D. Weinhandl Madlen Kaldirim, René Neuhaus, Reza Esmaillie, See related article by Assimon et al. (pp. 611–623). Xinping Li, Corinna Klein, Katrin Bohl, Maike Petersen, · Christian K. Frese, Martin Höhne, Ilian Atanassov, 523 .Patient-Reported Outcomes: Toward Better Markus M. Rinschen, Katja Höpker, Bernhard Measurement of Patient-Centered Care Schermer, Thomas Benzing, Christoph Dieterich, € in CKD Francesca Fabretti, and Roman-Ulrich Muller Albert W. Wu and Zachary S. Predmore See related article by Peipert et al. (pp. 654–663) 578 .Macula Densa SGLT1-NOS1-Tubuloglomerular · and Ware et al. (pp. 664–677). Feedback Pathway, a New Mechanism for Glomerular Hyperfiltration during Perspectives Hyperglycemia 526 You Are Just Now Telling Us About This? African Jie Zhang, Jin Wei, Shan Jiang, Lan Xu, Lei Wang, American Perspectives of Testing for Genetic Feng Cheng, Jacentha Buggs, Hermann Koepsell, Susceptibility to Kidney Disease Volker Vallon, and Ruisheng Liu Ebele M. Umeukeje, Bessie A. Young, Stephanie M. · See related editorial by Carlstro¨m (pp. 519–521). Fullerton, Kerri Cavanaugh, Delia Owens, James G. Wilson, Wylie Burke, and Erika Blacksher 594 DNMT1 in Six2 Progenitor Cells Is Essential for Transposable Element Silencing and Kidney 530 .Expanding the Patient’s Voice in Nephrology Development with Patient-Reported Outcomes Szu-Yuan Li, Jihwan Park, Yuting Guan, Kiwung Chung, John D. Peipert and Ron D. Hays Rojesh Shrestha, Matthew B. Palmer, and Katalin Susztak

BASIC RESEARCH CLINICAL EPIDEMIOLOGY

533 .Single-Cell RNA Profiling of Glomerular Cells 611 Comparative Cardiac Safety of Selective Shows Dynamic Changes in Experimental Serotonin Reuptake Inhibitors among Individuals Diabetic Kidney Disease Receiving Maintenance Hemodialysis Jia Fu, Kemal M. Akat, Zeguo Sun, Weijia Zhang, Detlef Magdalene M. Assimon, M. Alan Brookhart, Schlondorff, Zhihong Liu, Thomas Tuschl, Kyung Lee, and Jennifer E. Flythe and John Cijiang He · See related editorial by Weinhandl (pp. 521–523).

Red star . indicates articles that are features in This Month’s Highlights. CLINICAL RESEARCH Habbig, Wesley Hayes, Shivram Hegde, Saoussen Krid, Christoph Licht, Mieczyslaw Litwin, Mark Mayes, 625 .Archetype Analysis Identifies Distinct Profiles in Sevgi Mir, Rose Nemec, Lukasz Obrycki, Fabio Renal Transplant Recipients with Transplant Paglialonga, Stefano Picca, Charlotte Samaille, Mohan Glomerulopathy Associated with Allograft Shenoy, Manish D. Sinha, Brankica Spasojevic, Lynsey Survival Stronach, Enrico Vidal, Karel Vondrák, Alev Yilmaz, Olivier Aubert, Sarah Higgins, Yassine Bouatou, Daniel Ariane Zaloszyc, Michel Fischbach, Claus Peter Yoo, Marc Raynaud, Denis Viglietti, Marion Rabant, Luis Schmitt, and Franz Schaefer Hidalgo, Denis Glotz, Christophe Legendre, Michel Delahousse, Nikhil Shah, Banu Sis, Patricia Campbell, Michael Mengel, Xavier Jouven, Jean-Paul Duong Van 692 Early Acute Microvascular Kidney Transplant Huyen, Carmen Lefaucheur, and Alexandre Loupy Rejection in the Absence of Anti-HLA Antibodies Is Associated with Preformed IgG Antibodies 641 .Efficacy and Safety of Tenapanor in Patients with against Diverse Glomerular Endothelial Cell Hyperphosphatemia Receiving Maintenance Antigens Hemodialysis: A Randomized Phase 3 Trial Marianne Delville, Baptiste Lamarthée, Sylvain Pagie, Geoffrey A. Block, David P. Rosenbaum, Andrew Yan, Sarah B. See, Marion Rabant, Carole Burger, Philippe and Glenn M. Chertow Gatault, Magali Giral, Olivier Thaunat, Nadia Arzouk, Alexandre Hertig, Marc Hazzan, Marie Matignon, 654 .Kidney Disease Quality of Life 36-Item Short Form Christophe Mariat, Sophie Caillard, Nassim Kamar, Survey (KDQOL-36) Normative Values for the Johnny Sayegh, Pierre-François Westeel, Cyril United States Dialysis Population and New Single Garrouste, Marc Ladrière, Vincent Vuiblet, Joseph Summary Score Rivalan, Pierre Merville, Dominique Bertrand, Alain Le John D. Peipert, Devika Nair, Kristi Klicko, Moine, Jean Paul Duong Van Huyen, Anne Cesbron, Dorian R. Schatell, and Ron D. Hays Nicolas Cagnard, Olivier Alibeu, Simon C. Satchell, · See related editorial by Wu and Predmore Christophe Legendre, Emmanuel Zorn, Jean-Luc (pp. 523–525). Taupin, Béatrice Charreau, and Dany Anglicheau

. fi 664 Improving CKD-Speci c Patient-Reported LETTERS TO THE EDITOR Measures of Health-Related Quality of Life John E. Ware Jr., Michelle M. Richardson, Klemens B. 711 Renal Perfusion and Renal Nerve Activity Meyer, and Barbara Gandek Meyer D. Lifschitz See related editorial by Wu and Predmore · (pp. 523–525). 711 Authors’ Reply Bryan T. Haddock, Henrik Larsson, and Ulrik Andersen 678 Effects of Hemodiafiltration versus Conventional Hemodialysis in Children with ESKD: The HDF, 712 Complementary Roles for Single-Nucleus and Heart and Height Study Single-Cell RNA Sequencing in Kidney Disease Rukshana Shroff, Colette Smith, Bruno Ranchin, Aysun Research K. Bayazit, Constantinos J. Stefanidis, Varvara Askiti, Eoin D. O’Sullivan, Katie J. Mylonas, Jeremy Hughes, Karolis Azukaitis, Nur Canpolat, Ays¸eAgbas ¸,Helen and David A. Ferenbach Aitkenhead, Ali Anarat, Bilal Aoun, Daley Aofolaju, Sevcan Azime Bakkaloglu, Devina Bhowruth, Dagmara 714 Authors’ Reply Borzych-Duza_ łka, Ipek Kaplan Bulut, Rainer Buscher,€ Haojia Wu, Yuhei Kirita, Erinn L. Donnelly, John Deanfield, Claire Dempster, Ali Duzova, Sandra and Benjamin D. Humphreys