sign in sign up
<<
Home , Annexin A9, Carboxyglutamic acid, CBARA1, DHX36, EGLN1, FMO4

11/29/2010 Rubbia-Brandt et al. 1

Table S1: 613 up-regulated in SOS compared to control livers (FDR adjusted p-value ≤ 0.05) Fold- Chang adjusted p-value e (SOS p-value Symbol Name (SOS vs. vs. (SOS vs. Control) Contro Control) l) CCL20 chemokine (C-C motif) ligand 20 10.97 0.0001 0.0142 COL15A1 collagen, type XV, alpha 1 5.42 0.0000 0.0057 DLK1 delta-like 1 homolog (Drosophila) 4.30 0.0002 0.0171 CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 4.14 0.0001 0.0130 CRP C-reactive 4.01 0.0127 0.0339 GABBR1 gamma-aminobutyric acid (GABA) B , 1 3.77 0.0001 0.0167 SLC38A1 solute carrier family 38, member 1 3.70 0.0001 0.0155 pleckstrin homology-like domain, family A, PHLDA2 3.66 0.0007 0.0284 member 2 RASD1 RAS, dexamethasone-induced 1 3.65 0.0001 0.0168 FABP4 fatty acid binding protein 4, adipocyte 3.64 0.0000 0.0094 SOD2 superoxide dismutase 2, mitochondrial 3.50 0.0003 0.0205 COL1A2 collagen, type I, alpha 2 3.48 0.0001 0.0157 HBB hemoglobin, beta 3.46 0.0002 0.0173 heat shock protein 90kDa alpha (cytosolic), class HSP90AB1 3.43 0.0032 0.0498 B member 1 VWF von Willebrand factor 3.07 0.0000 0.0110 serpin peptidase inhibitor, clade E (nexin, SERPINE1 3.04 0.0018 0.0390 plasminogen activator inhibitor type fatty acid binding protein 5 (psoriasis- FABP5 3.04 0.0020 0.0412 associated) COL1A1 collagen, type I, alpha 1 3.03 0.0002 0.0171 GDF15 growth differentiation factor 15 3.02 0.0030 0.0487 EGF-containing fibulin-like EFEMP1 2.99 0.0000 0.0057 protein 1 methylenetetrahydrofolate dehydrogenase MTHFD2 2.99 0.0000 0.0071 (NADP+ dependent) 2, methenyltetrahydrof BIRC3 baculoviral IAP repeat-containing 3 2.99 0.0011 0.0323 CASP4 caspase 4, apoptosis-related cysteine peptidase 2.97 0.0003 0.0206 BCAT1 branched chain aminotransferase 1, cytosolic 2.93 0.0000 0.0087 COL4A1 collagen, type IV, alpha 1 2.92 0.0000 0.0057 Fc fragment of IgG, high affinity Ib, receptor FCGR1B 2.89 0.0001 0.0130 (CD64) IFI16 interferon, gamma-inducible protein 16 2.86 0.0008 0.0300 F2RL1 factor II () receptor-like 1 2.84 0.0015 0.0365 GPNMB glycoprotein (transmembrane) nmb 2.84 0.0009 0.0306 RGS4 regulator of G-protein signaling 4 2.82 0.0000 0.0057 SLC7A1 solute carrier family 7 (cationic 2.81 0.0001 0.0159 11/29/2010 Rubbia-Brandt et al. 2

transporter, y+ system), member 1 CCL2 chemokine (C-C motif) ligand 2 2.80 0.0009 0.0304 RRM2 ribonucleotide reductase M2 2.78 0.0000 0.0057 LON peptidase N-terminal domain and ring LONRF2 2.77 0.0002 0.0197 finger 2 IL32 interleukin 32 2.72 0.0006 0.0276 NAMPT nicotinamide phosphoribosyltransferase 2.72 0.0016 0.0372 G0S2 G0/G1switch 2 2.69 0.0010 0.0319 THBS2 thrombospondin 2 2.68 0.0000 0.0057 TNC tenascin C 2.64 0.0017 0.0379 CXCR4 chemokine (C-X-C motif) receptor 4 2.63 0.0009 0.0304 tankyrase, TRF1-interacting ankyrin-related TNKS2 2.61 0.0006 0.0272 ADP-ribose polymerase 2 CTHRC1 collagen triple helix repeat containing 1 2.60 0.0001 0.0130 THBS1 thrombospondin 1 2.58 0.0017 0.0379 SGMS2 sphingomyelin synthase 2 2.57 0.0020 0.0412 FRMD6 FERM domain containing 6 2.55 0.0009 0.0304 TNFAIP8 tumor necrosis factor, alpha-induced protein 8 2.53 0.0000 0.0079 EXT1 exostoses (multiple) 1 2.53 0.0025 0.0451 HSPA6 heat shock 70kDa protein 6 (HSP70B') 2.52 0.0007 0.0288 LBP lipopolysaccharide binding protein 2.52 0.0010 0.0320 BAG3 BCL2-associated athanogene 3 2.49 0.0007 0.0277 TOP2A topoisomerase (DNA) II alpha 170kDa 2.47 0.0001 0.0130 GK glycerol kinase 2.45 0.0005 0.0240 HBA1 /// HBA2 hemoglobin, alpha 1 /// hemoglobin, alpha 2 2.41 0.0001 0.0143 STC1 stanniocalcin 1 2.41 0.0000 0.0121 CCT2 chaperonin containing TCP1, subunit 2 (beta) 2.39 0.0022 0.0430 ODC1 decarboxylase 1 2.38 0.0011 0.0330 ER degradation enhancer, mannosidase alpha- EDEM3 2.38 0.0020 0.0410 like 3 GLIS3 GLIS family 3 2.38 0.0002 0.0187 ZNF295 zinc finger protein 295 2.37 0.0023 0.0439 aryl hydrocarbon receptor nuclear translocator- ARNTL2 2.37 0.0016 0.0376 like 2 LOXL4 lysyl oxidase-like 4 2.37 0.0022 0.0427 LOC387763 hypothetical protein LOC387763 2.36 0.0002 0.0171 FAT1 FAT tumor suppressor homolog 1 (Drosophila) 2.36 0.0028 0.0471 methylenetetrahydrofolate dehydrogenase MTHFD1L 2.36 0.0001 0.0130 (NADP+ dependent) 1-like FCGR1A /// Fc fragment of IgG, high affinity Ia, receptor 2.35 0.0001 0.0159 FCGR1C (CD64) /// Fc fragment of IgG, hi procollagen-lysine, 2-oxoglutarate 5- PLOD2 2.34 0.0007 0.0277 2 serpin peptidase inhibitor, clade B (ovalbumin), SERPINB1 2.34 0.0015 0.0365 member 1 11/29/2010 Rubbia-Brandt et al. 3

NCOA7 coactivator 7 2.32 0.0004 0.0224 FNDC3B fibronectin type III domain containing 3B 2.29 0.0010 0.0314 CHSY3 chondroitin sulfate synthase 3 2.29 0.0012 0.0340 C12orf5 12 open reading frame 5 2.28 0.0000 0.0130 CD69 CD69 molecule 2.28 0.0004 0.0230 GTP binding protein overexpressed in skeletal GEM 2.28 0.0011 0.0328 muscle CH25H cholesterol 25-hydroxylase 2.28 0.0011 0.0331 SOCS1 suppressor of cytokine signaling 1 2.27 0.0089 0.0491 PALLD palladin, cytoskeletal associated protein 2.26 0.0028 0.0469 DTL denticleless homolog (Drosophila) 2.26 0.0004 0.0226 TIMP1 TIMP metallopeptidase inhibitor 1 2.26 0.0000 0.0109 LOXL2 lysyl oxidase-like 2 2.25 0.0000 0.0057 serpin peptidase inhibitor, clade B (ovalbumin), SERPINB8 2.25 0.0012 0.0342 member 8 GPATCH4 G patch domain containing 4 2.25 0.0008 0.0300 LUM lumican 2.25 0.0004 0.0224 TOP1 topoisomerase (DNA) I 2.24 0.0019 0.0407 CTSC cathepsin C 2.24 0.0029 0.0478 potassium channel tetramerisation domain KCTD14 2.23 0.0028 0.0473 containing 14 PTGFRN prostaglandin F2 receptor negative regulator 2.23 0.0000 0.0124 VCAN versican 2.22 0.0026 0.0454 FBN1 fibrillin 1 2.22 0.0003 0.0221 MAP1B microtubule-associated protein 1B 2.22 0.0000 0.0083 ARL5B ADP-ribosylation factor-like 5B 2.22 0.0025 0.0449 COL4A2 collagen, type IV, alpha 2 2.21 0.0001 0.0141 STK17A serine/threonine kinase 17a 2.21 0.0006 0.0276 integrin, beta 1 (fibronectin receptor, beta ITGB1 2.20 0.0031 0.0492 polypeptide, antigen CD29 includes CSDA cold shock domain protein A 2.20 0.0003 0.0205 UDP-GlcNAc:betaGal beta-1,3-N- B3GNT5 2.19 0.0001 0.0159 acetylglucosaminyltransferase 5 VIM vimentin 2.18 0.0005 0.0241 pro-platelet basic protein (chemokine (C-X-C PPBP 2.17 0.0004 0.0235 motif) ligand 7) ATR ataxia telangiectasia and Rad3 related 2.17 0.0015 0.0367 IFNGR1 interferon gamma receptor 1 2.16 0.0006 0.0276 MKI67 (FHA domain) interacting nucleolar MKI67IP 2.16 0.0004 0.0236 phosphoprotein DDX21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 2.15 0.0016 0.0372 SLC35C1 solute carrier family 35, member C1 2.15 0.0015 0.0365 GOLM1 golgi membrane protein 1 2.15 0.0004 0.0226 XAF1 XIAP associated factor 1 2.14 0.0008 0.0297 HSPA2 heat shock 70kDa protein 2 2.13 0.0003 0.0205 11/29/2010 Rubbia-Brandt et al. 4

interleukin 6 signal transducer (gp130, IL6ST 2.13 0.0120 0.0313 oncostatin M receptor) ANXA2 A2 2.13 0.0001 0.0161 THBD thrombomodulin 2.13 0.0000 0.0130 apolipoprotein B mRNA editing , APOBEC3B 2.13 0.0003 0.0204 catalytic polypeptide-like 3B protein phosphatase 2, regulatory subunit B', PPP2R5E 2.13 0.0004 0.0235 epsilon isoform PBK PDZ binding kinase 2.13 0.0001 0.0141 TNFAIP3 tumor necrosis factor, alpha-induced protein 3 2.12 0.0006 0.0272 PLSCR1 phospholipid scramblase 1 2.12 0.0007 0.0287 DTNA dystrobrevin, alpha 2.12 0.0029 0.0478 NRP1 neuropilin 1 2.12 0.0014 0.0360 COL3A1 collagen, type III, alpha 1 2.12 0.0004 0.0223 LOC286434 hypothetical protein LOC286434 2.11 0.0007 0.0286 pregnancy-associated plasma protein A, PAPPA 2.11 0.0000 0.0065 pappalysin 1 DKC1 dyskeratosis congenita 1, dyskerin 2.11 0.0003 0.0221 NARG1 NMDA receptor regulated 1 2.10 0.0028 0.0471 TMEM165 transmembrane protein 165 2.09 0.0001 0.0153 CLEC7A C-type lectin domain family 7, member A 2.09 0.0032 0.0498 LOC100288985 hypothetical protein LOC100288985 2.09 0.0008 0.0292 structural maintenance of flexible SMCHD1 2.09 0.0017 0.0384 hinge domain containing 1 karyopherin alpha 2 (RAG cohort 1, importin KPNA2 2.08 0.0001 0.0167 alpha 1) MINA induced nuclear antigen 2.08 0.0016 0.0369 ETV6 ets variant 6 2.08 0.0013 0.0345 IER5 immediate early response 5 2.08 0.0002 0.0194 eukaryotic translation 1 EEF1E1 2.07 0.0006 0.0265 epsilon 1 IGSF6 immunoglobulin superfamily, member 6 2.07 0.0021 0.0425 FAM169B family with sequence similarity 169, member B 2.06 0.0019 0.0402 LGALS3 lectin, galactoside-binding, soluble, 3 2.06 0.0007 0.0276 tumor necrosis factor receptor superfamily, TNFRSF10A 2.05 0.0007 0.0276 member 10a v-myc myelocytomatosis viral oncogene MYC 2.05 0.0025 0.0450 homolog (avian) EHBP1L1 EH domain binding protein 1-like 1 2.05 0.0001 0.0137 solute carrier family 6 (neurotransmitter SLC6A6 2.05 0.0000 0.0057 transporter, taurine), member 6 RAB27A RAB27A, member RAS oncogene family 2.05 0.0004 0.0229 GAS2L3 Growth arrest-specific 2 like 3 2.04 0.0001 0.0130 GJC1 gap junction protein, gamma 1, 45kDa 2.04 0.0000 0.0094 11/29/2010 Rubbia-Brandt et al. 5

C7orf63 chromosome 7 open reading frame 63 2.04 0.0018 0.0395 TMEM49 Transmembrane protein 49 2.03 0.0003 0.0218 ANXA1 2.03 0.0020 0.0411 ADAM metallopeptidase with thrombospondin ADAMTS1 2.03 0.0008 0.0300 type 1 motif, 1 PNO1 partner of NOB1 homolog (S. cerevisiae) 2.02 0.0029 0.0481 MYOF myoferlin 2.02 0.0000 0.0130 CYR61 cysteine-rich, angiogenic inducer, 61 2.02 0.0024 0.0445 SGPP1 sphingosine-1-phosphate phosphatase 1 2.02 0.0013 0.0344 HPS5 Hermansky-Pudlak syndrome 5 2.02 0.0016 0.0372 epithelial cell transforming sequence 2 ECT2 2.02 0.0000 0.0057 oncogene LEPR leptin receptor 2.02 0.0015 0.0364 UTP14, U3 small nucleolar ribonucleoprotein, UTP14A 2.01 0.0010 0.0314 homolog A (yeast) TPM4 tropomyosin 4 2.01 0.0016 0.0372 NOP16 NOP16 nucleolar protein homolog (yeast) 2.00 0.0019 0.0404 NRIP1 nuclear receptor interacting protein 1 2.00 0.0026 0.0459 ZWINT ZW10 interactor 2.00 0.0002 0.0201 CKS2 CDC28 protein kinase regulatory subunit 2 1.99 0.0004 0.0234 RNASE6 ribonuclease, RNase A family, k6 1.99 0.0017 0.0384 RUFY3 RUN and FYVE domain containing 3 1.99 0.0003 0.0206 LPGAT1 lysophosphatidylglycerol acyltransferase 1 1.98 0.0022 0.0429 CLDN1 claudin 1 1.98 0.0020 0.0415 MLKL mixed lineage kinase domain-like 1.98 0.0009 0.0305 TMEM185B transmembrane protein 185B (pseudogene) 1.98 0.0002 0.0174 PAK1IP1 PAK1 interacting protein 1 1.97 0.0009 0.0309 tumor necrosis factor receptor superfamily, TNFRSF12A 1.97 0.0013 0.0345 member 12A PMP22 peripheral myelin protein 22 1.97 0.0000 0.0089 hemoglobin, gamma A /// hemoglobin, gamma HBG1 /// HBG2 1.97 0.0012 0.0335 G ALDH1A3 aldehyde dehydrogenase 1 family, member A3 1.97 0.0013 0.0346 LIMK2 LIM domain kinase 2 1.97 0.0019 0.0401 oligonucleotide/oligosaccharide-binding fold OBFC2A 1.96 0.0022 0.0431 containing 2A CPNE8 copine VIII 1.96 0.0008 0.0290 IDH3A isocitrate dehydrogenase 3 (NAD+) alpha 1.95 0.0007 0.0282 GYG1 glycogenin 1 1.95 0.0009 0.0304 ABLIM1 actin binding LIM protein 1 1.95 0.0025 0.0446 LAMB1 laminin, beta 1 1.95 0.0002 0.0171 MGP matrix Gla protein 1.95 0.0020 0.0409 interferon induced transmembrane protein 1 (9- IFITM1 1.94 0.0012 0.0340 27) SEC23B Sec23 homolog B (S. cerevisiae) 1.94 0.0031 0.0495 11/29/2010 Rubbia-Brandt et al. 6

C6orf41 chromosome 6 open reading frame 41 1.94 0.0014 0.0360 guanine nucleotide binding protein-like 3 GNL3 1.94 0.0014 0.0356 (nucleolar) ATPase, Na+/K+ transporting, beta 3 ATP1B3 1.94 0.0002 0.0192 polypeptide CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.93 0.0015 0.0365 FAM57A family with sequence similarity 57, member A 1.93 0.0006 0.0269 NOLC1 nucleolar and coiled-body phosphoprotein 1 1.93 0.0015 0.0367 ASNS asparagine synthetase 1.92 0.0004 0.0226 solute carrier organic anion transporter family, SLCO2A1 1.92 0.0000 0.0057 member 2A1 PCDH17 protocadherin 17 1.92 0.0003 0.0208 ISG20 interferon stimulated exonuclease gene 20kDa 1.91 0.0015 0.0365 C7orf68 chromosome 7 open reading frame 68 1.91 0.0023 0.0434 EGLN1 egl nine homolog 1 (C. elegans) 1.91 0.0013 0.0351 RRS1 biogenesis regulator homolog (S. RRS1 1.91 0.0026 0.0456 cerevisiae) signal transducer and activator of transcription STAT1 1.91 0.0012 0.0335 1, 91kDa SP110 SP110 nuclear body protein 1.91 0.0003 0.0213 SAP30 Sin3A-associated protein, 30kDa 1.91 0.0002 0.0183 ACBD3 acyl-Coenzyme A binding domain containing 3 1.90 0.0000 0.0126 serine palmitoyltransferase, long chain base SPTLC2 1.89 0.0002 0.0171 subunit 2 NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 1.89 0.0000 0.0057 UTP3, small subunit (SSU) processome UTP3 1.89 0.0009 0.0303 component, homolog (S. cerevisiae) protein tyrosine phosphatase, non-receptor PTPN2 1.89 0.0003 0.0221 type 2 TRIM15 tripartite motif-containing 15 1.88 0.0016 0.0372 CCL19 chemokine (C-C motif) ligand 19 1.88 0.0013 0.0349 EHD4 EH-domain containing 4 1.88 0.0001 0.0165 DKFZp686O241 Hypothetical protein DKFZp686O24166 1.88 0.0003 0.0205 66 heat shock 70kDa protein 5 (glucose-regulated HSPA5 1.88 0.0015 0.0362 protein, 78kDa) FAM129A family with sequence similarity 129, member A 1.88 0.0004 0.0233 hepatocyte growth factor (hepapoietin A; HGF 1.88 0.0000 0.0083 scatter factor) COL12A1 collagen, type XII, alpha 1 1.88 0.0003 0.0206 pleckstrin homology-like domain, family A, PHLDA1 1.88 0.0024 0.0441 member 1 NOP56 NOP56 ribonucleoprotein homolog (yeast) 1.88 0.0014 0.0356 ARMCX3 armadillo repeat containing, X-linked 3 1.88 0.0004 0.0225 signal transducer and activator of transcription 3 STAT3 1.87 0.0003 0.0221 (acute-phase response factor) 11/29/2010 Rubbia-Brandt et al. 7

ARF4 ADP-ribosylation factor 4 1.87 0.0030 0.0487 GJA1 gap junction protein, alpha 1, 43kDa 1.87 0.0001 0.0165 LOC541471 /// hypothetical LOC541471 /// non-protein coding 1.87 0.0015 0.0365 NCRNA00152 RNA 152 platelet-derived growth factor receptor, alpha PDGFRA 1.87 0.0003 0.0205 polypeptide ATP-binding cassette, sub-family E (OABP), ABCE1 1.87 0.0009 0.0309 member 1 TRAPPC4 trafficking protein particle complex 4 1.86 0.0006 0.0275 RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 1.86 0.0014 0.0355 TARS threonyl-tRNA synthetase 1.86 0.0009 0.0303 LYAR Ly1 antibody reactive homolog (mouse) 1.86 0.0007 0.0285 UTP14A /// UTP14, U3 small nucleolar ribonucleoprotein, 1.86 0.0006 0.0269 UTP14C homolog A (yeast) /// UTP14, U3 sma small nucleolar RNA host gene 12 (non-protein SNHG12 1.86 0.0009 0.0304 coding) TMEM33 transmembrane protein 33 1.85 0.0008 0.0290 PLDN pallidin homolog (mouse) 1.85 0.0012 0.0342 FAM60A family with sequence similarity 60, member A 1.85 0.0000 0.0094 SPON1 spondin 1, extracellular matrix protein 1.85 0.0011 0.0321 DENND4A DENN/MADD domain containing 4A 1.85 0.0006 0.0275 transporter 2, ATP-binding cassette, sub-family TAP2 1.85 0.0004 0.0230 B (MDR/TAP) IL1RL1 Interleukin 1 receptor-like 1 1.84 0.0022 0.0427 neural precursor cell expressed, NEDD9 1.84 0.0029 0.0475 developmentally down-regulated 9 ANLN anillin, actin binding protein 1.84 0.0007 0.0288 CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 1.84 0.0004 0.0225 PLVAP plasmalemma vesicle associated protein 1.84 0.0001 0.0130 ITM2A integral membrane protein 2A 1.84 0.0016 0.0369 C2orf55 chromosome 2 open reading frame 55 1.84 0.0001 0.0168 CYYR1 cysteine/tyrosine-rich 1 1.84 0.0004 0.0225 UDP-N-acetyl-alpha-D- GALNT2 galactosamine:polypeptide N- 1.83 0.0012 0.0332 acetylgalactosaminyltransferase TRIM27 tripartite motif-containing 27 1.83 0.0030 0.0488 FJX1 four jointed box 1 (Drosophila) 1.83 0.0005 0.0241 ribosomal RNA processing 15 homolog (S. RRP15 1.83 0.0011 0.0320 cerevisiae) SP100 SP100 nuclear antigen 1.83 0.0003 0.0208 MCAM melanoma cell adhesion molecule 1.83 0.0001 0.0168 VGLL3 vestigial like 3 (Drosophila) 1.83 0.0030 0.0484 C10orf2 open reading frame 2 1.82 0.0018 0.0390 ARFGAP3 ADP-ribosylation factor GTPase activating 1.82 0.0014 0.0357 11/29/2010 Rubbia-Brandt et al. 8

protein 3 UDP-N-acetyl-alpha-D- GALNT2 /// galactosamine:polypeptide N- 1.82 0.0014 0.0360 LOC100132910 acetylgalactosaminyltransferase chemokine (C-X-C motif) ligand 6 (granulocyte CXCL6 1.82 0.0025 0.0450 chemotactic protein 2) GK /// GK3P glycerol kinase /// glycerol kinase 3 pseudogene 1.81 0.0030 0.0487 RAN, member RAS oncogene family 1.81 0.0017 0.0386 C14orf147 open reading frame 147 1.81 0.0008 0.0293 guanine nucleotide binding protein-like 2 GNL2 1.81 0.0012 0.0340 (nucleolar) ectonucleoside triphosphate ENTPD7 1.81 0.0031 0.0495 diphosphohydrolase 7 FBLN5 fibulin 5 1.81 0.0003 0.0205 FAM46A family with sequence similarity 46, member A 1.81 0.0003 0.0223 2-oxoglutarate and iron-dependent OGFOD1 1.80 0.0028 0.0472 domain containing 1 PRSS23 protease, serine, 23 1.80 0.0001 0.0166 KLHL6 kelch-like 6 (Drosophila) 1.80 0.0008 0.0300 RBPMS RNA binding protein with multiple splicing 1.80 0.0002 0.0204 HBD hemoglobin, delta 1.80 0.0004 0.0237 MARCH1 membrane-associated ring finger (C3HC4) 1 1.80 0.0004 0.0232 KIF20A family member 20A 1.79 0.0001 0.0143 phosphoribosyl pyrophosphate PPAT 1.79 0.0030 0.0487 amidotransferase LSG1 large subunit GTPase 1 homolog (S. cerevisiae) 1.79 0.0010 0.0313 RHOQ ras homolog gene family, member Q 1.79 0.0021 0.0419 EMCN endomucin 1.79 0.0004 0.0234 TRNT1 tRNA nucleotidyl , CCA-adding, 1 1.78 0.0004 0.0228 BXDC2 brix domain containing 2 1.78 0.0013 0.0347 v-yes-1 Yamaguchi sarcoma viral related LYN 1.78 0.0004 0.0236 oncogene homolog RIOK1 RIO kinase 1 (yeast) 1.78 0.0010 0.0313 PRC1 protein regulator of cytokinesis 1 1.78 0.0002 0.0188 DST dystonin 1.78 0.0026 0.0456 TMEM200A transmembrane protein 200A 1.78 0.0004 0.0229 eukaryotic translation initiation factor 4A, EIF4A1 1.77 0.0001 0.0166 isoform 1 TFEC EC 1.77 0.0020 0.0410 integrin, alpha M (complement component 3 ITGAM 1.77 0.0016 0.0372 receptor 3 subunit) YAP1 Yes-associated protein 1, 65kDa 1.77 0.0002 0.0171 SLA Src-like-adaptor 1.77 0.0024 0.0441 CKAP4 cytoskeleton-associated protein 4 1.77 0.0028 0.0471 11/29/2010 Rubbia-Brandt et al. 9

pleckstrin homology domain containing, family A PLEKHA1 1.77 0.0019 0.0401 (phosphoinositide binding specif INTS6 integrator complex subunit 6 1.77 0.0007 0.0281 CDC2 cell division cycle 2, G1 to S and G2 to M 1.77 0.0003 0.0205 GTPBP4 GTP binding protein 4 1.77 0.0022 0.0426 DYNC1H1 , cytoplasmic 1, heavy chain 1 1.77 0.0028 0.0471 PECAM1 platelet/endothelial cell adhesion molecule 1.77 0.0005 0.0261 HYOU1 hypoxia up-regulated 1 1.76 0.0004 0.0235 ANXA5 1.76 0.0003 0.0221 ADAM metallopeptidase with thrombospondin ADAMTS9 1.76 0.0007 0.0278 type 1 motif, 9 ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 1.76 0.0010 0.0316 ANXA2P2 pseudogene 2 1.76 0.0002 0.0196 CENPK centromere protein K 1.76 0.0009 0.0303 MIR21 microRNA 21 1.76 0.0004 0.0223 GOLPH3 golgi phosphoprotein 3 (coat-protein) 1.76 0.0008 0.0297 TMEM22 transmembrane protein 22 1.76 0.0003 0.0221 solute carrier family 30 (zinc transporter), SLC30A7 1.76 0.0001 0.0163 member 7 SMAD5 SMAD family member 5 1.76 0.0003 0.0205 microtubule-associated protein 1 light chain 3 MAP1LC3B 1.75 0.0002 0.0203 beta BTB and CNC homology 1, basic BACH1 1.75 0.0022 0.0426 transcription factor 1 C20orf199 chromosome 20 open reading frame 199 1.75 0.0008 0.0300 LTV1 LTV1 homolog (S. cerevisiae) 1.75 0.0012 0.0339 Tax1 (human T-cell leukemia virus type I) TAX1BP3 1.75 0.0000 0.0110 binding protein 3 FAM60A /// family with sequence similarity 60, member A 1.75 0.0006 0.0269 LOC728115 /// similar to family with sequence SLAMF8 SLAM family member 8 1.75 0.0008 0.0297 phosphoribosylglycinamide formyltransferase, GART 1.75 0.0004 0.0236 phosphoribosylglycinamide synthetas tetratricopeptide repeat, ankyrin repeat and TANC1 1.74 0.0004 0.0226 coiled-coil containing 1 SNX9 sorting nexin 9 1.74 0.0004 0.0223 SCML4 sex comb on midleg-like 4 (Drosophila) 1.74 0.0022 0.0430 RPL22L1 ribosomal protein L22-like 1 1.74 0.0000 0.0124 minichromosome maintenance complex MCM6 1.74 0.0004 0.0224 component 6 GZMK granzyme K (granzyme 3; tryptase II) 1.74 0.0001 0.0159 KIAA0020 KIAA0020 1.74 0.0009 0.0304 FZD7 homolog 7 (Drosophila) 1.74 0.0014 0.0360 H2AFY H2A histone family, member Y 1.73 0.0004 0.0226 EIF2S2 eukaryotic translation initiation factor 2, subunit 1.73 0.0019 0.0406 11/29/2010 Rubbia-Brandt et al. 10 2 beta, 38kDa TMEM87B transmembrane protein 87B 1.73 0.0012 0.0334 PTRH2 peptidyl-tRNA 2 1.73 0.0013 0.0347 H2AFX H2A histone family, member X 1.73 0.0001 0.0137 Chromobox homolog 3 (HP1 gamma homolog, CBX3 1.73 0.0002 0.0171 Drosophila) ACSL3 acyl-CoA synthetase long-chain family member 3 1.73 0.0006 0.0272 small nuclear ribonucleoprotein D1 polypeptide SNRPD1 1.73 0.0007 0.0287 16kDa potassium channel tetramerisation domain KCTD12 1.73 0.0007 0.0285 containing 12 ODF2 outer dense fiber of sperm tails 2 1.72 0.0020 0.0412 MTUS1 mitochondrial tumor suppressor 1 1.72 0.0026 0.0454 COL4A4 collagen, type IV, alpha 4 1.72 0.0000 0.0130 tyrosine 3-/tryptophan 5- YWHAH 1.72 0.0001 0.0141 monooxygenase activation protein, eta poly ZXDB zinc finger, X-linked, duplicated B 1.71 0.0025 0.0447 FAM169A family with sequence similarity 169, member A 1.71 0.0007 0.0282 GFPT1 glutamine-fructose-6-phosphate transaminase 1 1.71 0.0018 0.0389 FTSJ1 FtsJ homolog 1 (E. coli) 1.71 0.0010 0.0318 TUBA1B , alpha 1b 1.71 0.0003 0.0204 C9orf21 chromosome 9 open reading frame 21 1.71 0.0015 0.0366 CUGBP2 CUG triplet repeat, RNA binding protein 2 1.71 0.0021 0.0424 TUBA1C tubulin, alpha 1c 1.71 0.0004 0.0234 PNPT1 polyribonucleotide nucleotidyltransferase 1 1.71 0.0006 0.0264 DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 1.71 0.0015 0.0365 EPHA3 EPH receptor A3 1.71 0.0026 0.0458 malignant fibrous histiocytoma amplified MFHAS1 1.71 0.0031 0.0490 sequence 1 PDE12 phosphodiesterase 12 1.70 0.0022 0.0429 PANX1 pannexin 1 1.70 0.0026 0.0456 NDC80 homolog, kinetochore complex NDC80 1.70 0.0000 0.0121 component (S. cerevisiae) SWI/SNF related, matrix associated, actin SMARCA5 1.70 0.0005 0.0249 dependent regulator of chromatin, subf SDAD1 SDA1 domain containing 1 1.70 0.0008 0.0297 PDLIM3 PDZ and LIM domain 3 1.69 0.0018 0.0390 RECQL RecQ protein-like (DNA Q1-like) 1.69 0.0000 0.0130 PRDM1 PR domain containing 1, with ZNF domain 1.69 0.0019 0.0405 MAK16 MAK16 homolog (S. cerevisiae) 1.69 0.0025 0.0449 CD44 CD44 molecule (Indian blood group) 1.69 0.0022 0.0431 PON2 paraoxonase 2 1.69 0.0014 0.0361 MSN moesin 1.69 0.0000 0.0057 LRRC59 leucine rich repeat containing 59 1.69 0.0010 0.0314 PARP1 poly (ADP-ribose) polymerase 1 1.69 0.0010 0.0320 11/29/2010 Rubbia-Brandt et al. 11 monocyte to macrophage differentiation- MMD 1.69 0.0020 0.0412 associated SPTBN1 spectrin, beta, non-erythrocytic 1 1.69 0.0000 0.0124 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 UBE2D1 1.69 0.0009 0.0310 homolog, yeast) SQRDL sulfide quinone reductase-like (yeast) 1.69 0.0011 0.0321 nucleolar complex associated 3 homolog (S. NOC3L 1.69 0.0009 0.0310 cerevisiae) XRN2 5'-3' exoribonuclease 2 1.68 0.0017 0.0386 WDR36 WD repeat domain 36 1.68 0.0016 0.0369 RAB31 RAB31, member RAS oncogene family 1.68 0.0016 0.0369 RBM17 RNA binding motif protein 17 1.68 0.0018 0.0396 PNPLA8 patatin-like phospholipase domain containing 8 1.68 0.0008 0.0292 DCAF13 DDB1 and CUL4 associated factor 13 1.68 0.0009 0.0307 RPL37A ribosomal protein L37a 1.68 0.0012 0.0340 binding, cytoplasmic RNA SYNCRIP 1.68 0.0003 0.0205 interacting protein USP38 ubiquitin specific peptidase 38 1.68 0.0023 0.0434 eukaryotic translation initiation factor 3, subunit EIF3J 1.68 0.0016 0.0372 J TP53RK TP53 regulating kinase 1.67 0.0014 0.0355 RPAP3 RNA polymerase II associated protein 3 1.67 0.0004 0.0226 PLAT plasminogen activator, tissue 1.67 0.0013 0.0346 low density lipoprotein receptor class A domain LDLRAD3 1.67 0.0000 0.0114 containing 3 IGFBP7 insulin-like growth factor binding protein 7 1.67 0.0026 0.0458 RBP7 retinol binding protein 7, cellular 1.67 0.0011 0.0322 NIP7 nuclear import 7 homolog (S. cerevisiae) 1.67 0.0032 0.0496 NADH dehydrogenase (ubiquinone) 1 alpha NDUFAF4 1.67 0.0022 0.0425 subcomplex, assembly factor 4 CHIC2 cysteine-rich hydrophobic domain 2 1.67 0.0001 0.0152 LGALS8 lectin, galactoside-binding, soluble, 8 1.67 0.0016 0.0374 TSR1, 20S rRNA accumulation, homolog (S. TSR1 1.67 0.0021 0.0422 cerevisiae) RBMXL1 RNA binding motif protein, X-linked-like 1 1.67 0.0029 0.0481 ARPC5L actin related protein 2/3 complex, subunit 5-like 1.67 0.0002 0.0172 PODXL podocalyxin-like 1.67 0.0000 0.0124 GARS glycyl-tRNA synthetase 1.66 0.0003 0.0206 NUSAP1 nucleolar and spindle associated protein 1 1.66 0.0032 0.0497 CAPN2 2, (m/II) large subunit 1.66 0.0025 0.0447 major histocompatibility complex, class II, DP HLA-DPB1 1.66 0.0015 0.0362 beta 1 splicing factor /glutamine-rich SFPQ 1.66 0.0021 0.0417 (polypyrimidine tract binding protein ass 11/29/2010 Rubbia-Brandt et al. 12 HLA-DRB1 /// major histocompatibility complex, class II, DR HLA-DRB3 /// 1.66 0.0017 0.0387 beta 1 /// major histocompatibili HLA-DRB4 DCN1, defective in cullin neddylation 1, domain DCUN1D5 1.66 0.0009 0.0304 containing 5 (S. cerevisiae) AGFG1 ArfGAP with FG repeats 1 1.66 0.0009 0.0304 budding uninhibited by benzimidazoles 1 BUB1B 1.66 0.0001 0.0140 homolog beta (yeast) GFPT2 glutamine-fructose-6-phosphate transaminase 2 1.66 0.0010 0.0320 CD200 CD200 molecule 1.66 0.0013 0.0345 PMM2 phosphomannomutase 2 1.66 0.0014 0.0357 BICD2 bicaudal D homolog 2 (Drosophila) 1.66 0.0021 0.0425 THUMPD3 THUMP domain containing 3 1.66 0.0008 0.0300 DHX9 DEAH (Asp-Glu-Ala-His) box polypeptide 9 1.66 0.0030 0.0482 SNHG5 /// small nucleolar RNA host gene 5 (non-protein SNORD50A /// 1.66 0.0010 0.0313 coding) /// small nucleolar RNA, C/ SNORD50B THADA Thyroid adenoma associated 1.65 0.0027 0.0466 TATA box binding protein (TBP)-associated TAF1D 1.65 0.0011 0.0320 factor, RNA polymerase I, D, 41kDa WAS/WASL interacting , member WIPF1 1.65 0.0001 0.0168 1 IPO7 importin 7 1.65 0.0012 0.0340 LOX lysyl oxidase 1.65 0.0027 0.0465 SRM spermidine synthase 1.65 0.0019 0.0399 solute carrier family 25 (mitochondrial carrier; SLC25A24 1.65 0.0008 0.0293 phosphate carrier), member 24 COL5A1 collagen, type V, alpha 1 1.65 0.0006 0.0276 CALU calumenin 1.65 0.0016 0.0372 TEAD4 TEA domain family member 4 1.65 0.0022 0.0431 S100A11 S100 calcium binding protein A11 1.65 0.0004 0.0226 tRNA methyltransferase 11 homolog (S. TRMT11 1.64 0.0006 0.0276 cerevisiae) cysteine-rich secretory protein LCCL domain CRISPLD2 1.64 0.0004 0.0224 containing 2 ubiquitin-like with PHD and ring finger domains UHRF1 1.64 0.0002 0.0171 1 CD93 CD93 molecule 1.64 0.0001 0.0145 CCDC86 coiled-coil domain containing 86 1.64 0.0025 0.0446 GSN (amyloidosis, Finnish type) 1.64 0.0011 0.0330 PPA1 pyrophosphatase (inorganic) 1 1.64 0.0020 0.0415 serpin peptidase inhibitor, clade H (heat shock SERPINH1 1.64 0.0003 0.0205 protein 47), member 1, (collagen TRAF-interacting protein with forkhead- TIFA 1.64 0.0016 0.0372 associated domain 11/29/2010 Rubbia-Brandt et al. 13 GMFB glia maturation factor, beta 1.64 0.0001 0.0167 FAM3C family with sequence similarity 3, member C 1.64 0.0003 0.0221 KBTBD2 kelch repeat and BTB (POZ) domain containing 2 1.64 0.0015 0.0367 caspase 1, apoptosis-related cysteine peptidase CASP1 1.64 0.0005 0.0250 (interleukin 1, beta, convertase ILF2 interleukin enhancer binding factor 2, 45kDa 1.63 0.0031 0.0489 phosphoinositide-3-kinase, regulatory subunit 3 PIK3R3 1.63 0.0000 0.0079 (gamma) STC2 stanniocalcin 2 1.63 0.0000 0.0057 IL15RA interleukin 15 receptor, alpha 1.63 0.0021 0.0420 heparan sulfate (glucosamine) 3-O- HS3ST1 1.63 0.0024 0.0441 sulfotransferase 1 ribosome binding protein 1 homolog 180kDa RRBP1 1.63 0.0001 0.0138 (dog) SEH1L SEH1-like (S. cerevisiae) 1.63 0.0011 0.0331 RAB8B RAB8B, member RAS oncogene family 1.63 0.0027 0.0466 transcription factor 3 1.63 0.0002 0.0181 POGK pogo transposable element with KRAB domain 1.63 0.0021 0.0416 BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) 1.63 0.0012 0.0342 VEGFC vascular endothelial growth factor C 1.63 0.0001 0.0166 HEPH hephaestin 1.62 0.0007 0.0287 HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 1.62 0.0012 0.0338 THY1 Thy-1 cell surface antigen 1.62 0.0000 0.0103 PRKCI protein kinase C, iota 1.62 0.0032 0.0495 KPNA4 karyopherin alpha 4 (importin alpha 3) 1.62 0.0010 0.0313 platelet-derived growth factor alpha PDGFA 1.62 0.0010 0.0313 polypeptide RLIM ring finger protein, LIM domain interacting 1.62 0.0012 0.0338 glycerol-3-phosphate dehydrogenase 2 GPD2 1.62 0.0002 0.0171 (mitochondrial) solute carrier family 7 (cationic amino acid SLC7A6 1.62 0.0001 0.0130 transporter, y+ system), member 6 PRP40 pre-mRNA processing factor 40 homolog PRPF40A 1.62 0.0009 0.0305 A (S. cerevisiae) TES testis derived transcript (3 LIM domains) 1.62 0.0005 0.0259 COTL1 coactosin-like 1 (Dictyostelium) 1.62 0.0008 0.0297 IARS isoleucyl-tRNA synthetase 1.62 0.0017 0.0384 FRMD8 FERM domain containing 8 1.62 0.0000 0.0130 SRPRB signal recognition particle receptor, B subunit 1.62 0.0026 0.0459 GSPT1 G1 to S phase transition 1 1.62 0.0013 0.0347 SETX senataxin 1.61 0.0005 0.0242 CCDC50 coiled-coil domain containing 50 1.61 0.0004 0.0233 TNPO1 transportin 1 1.61 0.0016 0.0368 RANBP2 RAN binding protein 2 1.61 0.0006 0.0275 BAZ1A bromodomain adjacent to zinc finger domain, 1.61 0.0008 0.0289 11/29/2010 Rubbia-Brandt et al. 14 1A GOLT1B golgi transport 1 homolog B (S. cerevisiae) 1.61 0.0004 0.0235 C10orf18 chromosome 10 open reading frame 18 1.61 0.0005 0.0246 SARS Seryl-tRNA synthetase 1.61 0.0002 0.0184 PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 1.61 0.0023 0.0436 secreted protein, acidic, cysteine-rich SPARC 1.61 0.0003 0.0221 () NUDCD1 NudC domain containing 1 1.61 0.0011 0.0320 HMOX2 (decycling) 2 1.61 0.0007 0.0282 protein tyrosine phosphatase, non-receptor PTPN12 1.60 0.0002 0.0200 type 12 SELS selenoprotein S 1.60 0.0013 0.0345 CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 1.60 0.0012 0.0341 CDKN3 cyclin-dependent kinase inhibitor 3 1.60 0.0006 0.0265 ACVR1B activin A receptor, type IB 1.60 0.0027 0.0466 FYB FYN binding protein (FYB-120/130) 1.59 0.0022 0.0426 of outer mitochondrial membrane TOMM40L 1.59 0.0004 0.0235 40 homolog (yeast)-like VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 1.59 0.0002 0.0202 OSBPL3 oxysterol binding protein-like 3 1.59 0.0000 0.0121 major histocompatibility complex, class II, DP HLA-DPA1 1.59 0.0031 0.0494 alpha 1 RGS10 regulator of G-protein signaling 10 1.59 0.0008 0.0297 IL27RA interleukin 27 receptor, alpha 1.59 0.0004 0.0226 NLRC5 NLR family, CARD domain containing 5 1.59 0.0000 0.0110 HELLS helicase, lymphoid-specific 1.59 0.0008 0.0297 DHX15 DEAH (Asp-Glu-Ala-His) box polypeptide 15 1.59 0.0020 0.0407 AEBP1 AE binding protein 1 1.59 0.0001 0.0130 MYO5A VA (heavy chain 12, myoxin) 1.59 0.0032 0.0499 TUSC3 tumor suppressor candidate 3 1.59 0.0030 0.0484 hepatoma-derived growth factor, related HDGFRP3 1.59 0.0001 0.0137 protein 3 ESF1, nucleolar pre-rRNA processing protein, ESF1 1.59 0.0003 0.0222 homolog (S. cerevisiae) TMEM43 transmembrane protein 43 1.58 0.0022 0.0429 protein phosphatase 2 (formerly 2A), regulatory PPP2R1B 1.58 0.0011 0.0331 subunit A, beta isoform MEAF6 MYST/Esa1-associated factor 6 1.58 0.0004 0.0226 ATPase, Na+/K+ transporting, alpha 1 ATP1A1 1.58 0.0019 0.0405 polypeptide C1orf55 open reading frame 55 1.58 0.0023 0.0438 PPIA peptidylprolyl A (cyclophilin A) 1.58 0.0002 0.0171 CD109 CD109 molecule 1.58 0.0005 0.0241 C9orf30 chromosome 9 open reading frame 30 1.58 0.0009 0.0304 CD8A CD8a molecule 1.58 0.0028 0.0471 11/29/2010 Rubbia-Brandt et al. 15 TATA box binding protein (TBP)-associated TAF1B 1.58 0.0009 0.0304 factor, RNA polymerase I, B, 63kDa sprouty homolog 1, antagonist of FGF signaling SPRY1 1.58 0.0004 0.0234 (Drosophila) signal peptidase complex subunit 3 homolog (S. SPCS3 1.58 0.0001 0.0165 cerevisiae) M-phase phosphoprotein 10 (U3 small nucleolar MPHOSPH10 1.57 0.0005 0.0237 ribonucleoprotein) SEC23IP SEC23 interacting protein 1.57 0.0019 0.0404 SWAP70 SWAP switching B-cell complex 70kDa subunit 1.57 0.0029 0.0482 UBE2S ubiquitin-conjugating enzyme E2S 1.57 0.0001 0.0166 Ctr9, Paf1/RNA polymerase II complex CTR9 1.57 0.0016 0.0372 component, homolog (S. cerevisiae) OTUD6B OTU domain containing 6B 1.57 0.0025 0.0448 RAB6A /// RAB6A, member RAS oncogene family /// 1.57 0.0011 0.0330 RAB6C RAB6C, member RAS oncogene family SSRP1 structure specific recognition protein 1 1.57 0.0004 0.0234 FAR1 fatty acyl CoA reductase 1 1.57 0.0014 0.0355 DNM1L 1-like 1.57 0.0020 0.0412 LARS leucyl-tRNA synthetase 1.57 0.0028 0.0470 LAPTM5 lysosomal protein transmembrane 5 1.57 0.0024 0.0445 KITLG KIT ligand 1.57 0.0031 0.0494 TRAM2 translocation associated membrane protein 2 1.56 0.0030 0.0487 tyrosine 3-monooxygenase/tryptophan 5- YWHAZ 1.56 0.0009 0.0307 monooxygenase activation protein, zeta pol WBP5 WW domain binding protein 5 1.56 0.0006 0.0276 BZW1 /// basic leucine zipper and W2 domains 1 /// basic 1.56 0.0011 0.0331 BZW1L1 leucine zipper and W2 domains 1 ZBTB8A zinc finger and BTB domain containing 8A 1.56 0.0005 0.0249 discs, large (Drosophila) homolog-associated DLGAP4 1.56 0.0001 0.0168 protein 4 TSHZ2 teashirt zinc finger 2 1.56 0.0004 0.0224 HCK hemopoietic cell kinase 1.56 0.0028 0.0473 MARS methionyl-tRNA synthetase 1.56 0.0018 0.0390 GPX3 glutathione peroxidase 3 (plasma) 1.56 0.0010 0.0314 solute carrier family 1 (neuronal/epithelial high SLC1A1 1.56 0.0015 0.0365 affinity glutamate transporter LIMS1 LIM and senescent cell antigen-like domains 1 1.56 0.0023 0.0435 EZH2 enhancer of zeste homolog 2 (Drosophila) 1.56 0.0005 0.0242 NUP50 nucleoporin 50kDa 1.56 0.0004 0.0226 EBF1 early B-cell factor 1 1.56 0.0025 0.0447 DLAT dihydrolipoamide S-acetyltransferase 1.56 0.0021 0.0422 ZNHIT6 zinc finger, HIT type 6 1.56 0.0010 0.0316 BYSL bystin-like 1.56 0.0032 0.0497 GOT1 glutamic-oxaloacetic transaminase 1, soluble 1.56 0.0017 0.0384 11/29/2010 Rubbia-Brandt et al. 16 (aspartate aminotransferase 1) PVR poliovirus receptor 1.55 0.0022 0.0429 ZEB1 zinc finger E-box binding homeobox 1 1.55 0.0009 0.0312 heat shock protein 90kDa alpha (cytosolic), class HSP90AA1 1.55 0.0029 0.0478 A member 1 TTL tubulin tyrosine 1.55 0.0000 0.0120 microtubule-associated protein, RP/EB family, MAPRE1 1.55 0.0009 0.0304 member 1 CCNL1 Cyclin L1 1.55 0.0003 0.0216 SEC24A SEC24 family, member A (S. cerevisiae) 1.55 0.0011 0.0330 DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 1.55 0.0009 0.0304 TAF4b RNA polymerase II, TATA box binding TAF4B 1.55 0.0001 0.0167 protein (TBP)-associated factor, 105kD ubiquitin-conjugating enzyme E2, J1 (UBC6 UBE2J1 1.55 0.0015 0.0365 homolog, yeast) UMPS uridine monophosphate synthetase 1.55 0.0022 0.0426 (prosome, macropain) 26S subunit, PSMD12 1.54 0.0007 0.0283 non-ATPase, 12 FOXO3 /// forkhead box O3 /// forkhead box O3B 1.54 0.0008 0.0290 FOXO3B pseudogene PTN pleiotrophin 1.54 0.0030 0.0487 CD48 CD48 molecule 1.54 0.0023 0.0439 COL5A2 collagen, type V, alpha 2 1.54 0.0020 0.0413 granzyme A (granzyme 1, cytotoxic T- GZMA 1.54 0.0024 0.0444 lymphocyte-associated serine esterase 3) ACTR2 ARP2 actin-related protein 2 homolog (yeast) 1.54 0.0025 0.0452 FMNL2 formin-like 2 1.54 0.0001 0.0161 COL6A3 collagen, type VI, alpha 3 1.54 0.0003 0.0205 ILF3 interleukin enhancer binding factor 3, 90kDa 1.54 0.0029 0.0477 NXT1 NTF2-like export factor 1 1.54 0.0022 0.0427 CLIC1 chloride intracellular channel 1 1.54 0.0008 0.0300 RBM3 RNA binding motif (RNP1, RRM) protein 3 1.54 0.0021 0.0416 CDC16 cell division cycle 16 homolog (S. cerevisiae) 1.54 0.0028 0.0469 MAML2 mastermind-like 2 (Drosophila) 1.54 0.0027 0.0468 DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 1.54 0.0030 0.0487 eukaryotic translation initiation factor 2, subunit EIF2S1 1.53 0.0016 0.0369 1 alpha, 35kDa LOC286434 /// hypothetical protein LOC286434 /// similar to LOC389906 /// 1.53 0.0019 0.0401 Serine/threonine-protein kinase PR LOC729162 ectonucleoside triphosphate ENTPD1 1.53 0.0013 0.0346 diphosphohydrolase 1 B double prime 1, subunit of RNA polymerase III BDP1 1.53 0.0031 0.0495 transcription initiation factor 11/29/2010 Rubbia-Brandt et al. 17 HEATR1 HEAT repeat containing 1 1.53 0.0015 0.0362 actin related protein 2/3 complex, subunit 1B, ARPC1B 1.53 0.0003 0.0223 41kDa DNMT1 DNA (cytosine-5-)-methyltransferase 1 1.53 0.0001 0.0152 SRPX sushi-repeat-containing protein, X-linked 1.53 0.0008 0.0297 RFFL ring finger and FYVE-like domain containing 1 1.53 0.0008 0.0293 C17orf100 chromosome 17 open reading frame 100 1.53 0.0030 0.0487 IWS1 IWS1 homolog (S. cerevisiae) 1.53 0.0006 0.0272 ZNF57 zinc finger protein 57 1.53 0.0026 0.0459 CDC42SE1 CDC42 small effector 1 1.53 0.0001 0.0152 CD300LG CD300 molecule-like family member g 1.53 0.0007 0.0282 protein tyrosine phosphatase, non-receptor PTPN22 1.53 0.0030 0.0487 type 22 (lymphoid) DBF4 DBF4 homolog (S. cerevisiae) 1.53 0.0004 0.0233 heparan sulfate (glucosamine) 3-O- HS3ST2 1.53 0.0015 0.0361 sulfotransferase 2 VEZF1 vascular endothelial zinc finger 1 1.53 0.0012 0.0340 hypoxia inducible factor 1, alpha subunit (basic HIF1A 1.53 0.0006 0.0276 helix-loop-helix transcription squamous cell carcinoma antigen recognized by SART3 1.53 0.0004 0.0237 T cells 3 PFKP phosphofructokinase, platelet 1.52 0.0000 0.0110 SPA17 sperm autoantigenic protein 17 1.52 0.0032 0.0499 YME1L1 YME1-like 1 (S. cerevisiae) 1.52 0.0007 0.0279 solute carrier family 12 SLC12A2 (sodium/potassium/chloride transporters), 1.52 0.0004 0.0226 member 2 ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 1.52 0.0008 0.0297 matrix metallopeptidase 2 (gelatinase A, 72kDa MMP2 1.52 0.0003 0.0223 gelatinase, 72kDa type IV collage TAGLN2 transgelin 2 1.52 0.0019 0.0404 IVNS1ABP influenza virus NS1A binding protein 1.52 0.0017 0.0379 CXorf26 chromosome X open reading frame 26 1.52 0.0019 0.0400 RABGGTB geranylgeranyltransferase, beta subunit 1.52 0.0029 0.0477 ATPase, H+ transporting, lysosomal V0 subunit ATP6V0A2 1.52 0.0013 0.0349 a2 HN1 hematological and neurological expressed 1 1.52 0.0013 0.0346 DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 1.52 0.0023 0.0436 CXorf38 chromosome X open reading frame 38 1.52 0.0008 0.0295 SLFN11 schlafen family member 11 1.52 0.0007 0.0287 HTRA1 HtrA serine peptidase 1 1.52 0.0010 0.0314 IL6 interleukin 6 1.52 0.0804 0.02480 vesicle-associated membrane protein 5 VAMP5 1.52 0.0003 0.0223 (myobrevin) IFI30 interferon, gamma-inducible protein 30 1.52 0.0014 0.0356 11/29/2010 Rubbia-Brandt et al. 18 low density lipoprotein receptor-related protein LRP10 1.52 0.0000 0.0102 10 TRBC1 T cell receptor beta constant 1 1.52 0.0010 0.0313 TMSB10 thymosin beta 10 1.52 0.0000 0.0079 DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 1.51 0.0020 0.0411 solute carrier family 16, member 3 SLC16A3 1.51 0.0016 0.0369 (monocarboxylic acid transporter 4) leukocyte-associated immunoglobulin-like LAIR1 1.51 0.0001 0.0171 receptor 1 THEMIS thymocyte selection associated 1.51 0.0015 0.0365 BTBD1 BTB (POZ) domain containing 1 1.51 0.0001 0.0130 5-methyltetrahydrofolate-homocysteine MTRR 1.51 0.0015 0.0365 methyltransferase reductase SFRS2 splicing factor, arginine/serine-rich 2 1.51 0.0003 0.0205 PLIN3 perilipin 3 1.51 0.0000 0.0130 non-metastatic cells 1, protein (NM23A) NME1 1.51 0.0008 0.0300 expressed in HSPA4 heat shock 70kDa protein 4 1.51 0.0002 0.0195 mesoderm induction early response 1 homolog MIER1 1.51 0.0025 0.0446 (Xenopus laevis) WARS tryptophanyl-tRNA synthetase 1.51 0.0000 0.0081 carcinoembryonic antigen-related cell adhesion CEACAM1 1.51 0.0005 0.0237 molecule 1 (biliary glycoprotein) GINS1 GINS complex subunit 1 (Psf1 homolog) 1.51 0.0007 0.0286 RACGAP1 Rac GTPase activating protein 1 1.51 0.0023 0.0434 C10orf119 chromosome 10 open reading frame 119 1.51 0.0020 0.0408 FAM108C1 family with sequence similarity 108, member C1 1.51 0.0028 0.0471 proteasome (prosome, macropain) activator PSME3 1.51 0.0014 0.0355 subunit 3 (PA28 gamma; Ki) UTP11-like, U3 small nucleolar UTP11L 1.50 0.0008 0.0300 ribonucleoprotein, (yeast) ACTN1 actinin, alpha 1 1.50 0.0000 0.0120 SSR1 signal sequence receptor, alpha 1.50 0.0015 0.0361 GLRX2 glutaredoxin 2 1.50 0.0030 0.0487

Table S2: 300 down-regulated genes in SOS compared to control livers Fold- adjusted p-value Change p-value Gene Symbol Name (SOS vs. (SOS vs. (SOS vs. Control) Control) Control) cytochrome P450, family 7, subfamily A, CYP7A1 -5.36 0.0016 0.0369 polypeptide 1 KANK4 KN motif and ankyrin repeat domains 4 -3.59 0.0000 0.0057 HEATR7B1 HEAT repeat containing 7B1 -3.57 0.0010 0.0313 THRSP thyroid hormone responsive (SPOT14 -3.46 0.0005 0.0260 11/29/2010 Rubbia-Brandt et al. 19 homolog, rat) ZNF385B zinc finger protein 385B -3.04 0.0013 0.0351 C5orf13 chromosome 5 open reading frame 13 -2.85 0.0011 0.0331 ZGPAT zinc finger, CCCH-type with G patch domain -2.76 0.0004 0.0227 VSNL1 visinin-like 1 -2.75 0.0008 0.0293 sulfotransferase family 1E, estrogen- SULT1E1 -2.70 0.0013 0.0352 preferring, member 1 MREG melanoregulin -2.62 0.0020 0.0412 diacylglycerol O-acyltransferase homolog 2 DGAT2 -2.60 0.0001 0.0137 (mouse) glycerol-3-phosphate acyltransferase, GPAM -2.57 0.0002 0.0198 mitochondrial ATP-binding cassette, sub-family C, member 6 ABCC6P1 -2.52 0.0002 0.0204 pseudogene 1 GIPC2 GIPC PDZ domain containing family, member 2 -2.49 0.0007 0.0276 AGBL2 ATP/GTP binding protein-like 2 -2.48 0.0000 0.0079 C10orf114 chromosome 10 open reading frame 114 -2.47 0.0009 0.0310 protein phosphatase 1, regulatory (inhibitor) PPP1R1A -2.47 0.0000 0.0057 subunit 1A GLYAT glycine-N-acyltransferase -2.44 0.0002 0.0174 GSTA1 glutathione S-transferase alpha 1 -2.43 0.0019 0.0401 SCG5 secretogranin V (7B2 protein) -2.41 0.0009 0.0308 DNMT3L DNA (cytosine-5-)-methyltransferase 3-like -2.40 0.0001 0.0168 AMACR alpha-methylacyl-CoA racemase -2.37 0.0018 0.0390 SH3RF2 SH3 domain containing ring finger 2 -2.35 0.0013 0.0346 LOC149703 hypothetical protein LOC149703 -2.33 0.0011 0.0322 ATOH7 atonal homolog 7 (Drosophila) -2.33 0.0000 0.0070 HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 -2.28 0.0000 0.0124 LOC730101 hypothetical LOC730101 -2.27 0.0004 0.0233 SORBS2 sorbin and SH3 domain containing 2 -2.24 0.0022 0.0429 butyrobetaine (gamma), 2-oxoglutarate BBOX1 -2.23 0.0009 0.0302 dioxygenase (gamma-butyrobetaine hydroxyla C10orf140 chromosome 10 open reading frame 140 -2.23 0.0016 0.0372 HAPLN4 hyaluronan and proteoglycan link protein 4 -2.22 0.0001 0.0159 protein phosphatase 1, regulatory (inhibitor) PPP1R3C -2.22 0.0007 0.0278 subunit 3C LOC100130232 LP2209 -2.20 0.0008 0.0300 RAB26 RAB26, member RAS oncogene family -2.17 0.0021 0.0425 SEC14L2 SEC14-like 2 (S. cerevisiae) -2.16 0.0005 0.0250 ETNK2 ethanolamine kinase 2 -2.15 0.0000 0.0094 NINL ninein-like -2.13 0.0011 0.0330 MEGF10 multiple EGF-like-domains 10 -2.13 0.0000 0.0121 dihydrodipicolinate synthase-like, DHDPSL -2.12 0.0009 0.0312 mitochondrial 11/29/2010 Rubbia-Brandt et al. 20 SLC2A4RG SLC2A4 regulator -2.12 0.0006 0.0270 MME membrane metallo-endopeptidase -2.09 0.0004 0.0226 TSKU tsukushin -2.08 0.0011 0.0323 CCL14 /// chemokine (C-C motif) ligand 14 /// CCL14-CCL15 /// -2.08 0.0001 0.0167 chemokine ligand 14, chemokine ligand 15 tra CCL15 HAO2 hydroxyacid oxidase 2 (long chain) -2.06 0.0009 0.0304 C14orf167 chromosome 14 open reading frame 167 -2.06 0.0019 0.0400 solute carrier family 22 (organic anion SLC22A7 -2.02 0.0029 0.0478 transporter), member 7 CAPN3 calpain 3, (p94) -2.02 0.0001 0.0130 LIME1 Lck interacting transmembrane adaptor 1 -2.01 0.0005 0.0242 MOGAT2 monoacylglycerol O-acyltransferase 2 -2.01 0.0010 0.0320 N-acetyltransferase 1 (arylamine N- NAT1 -2.01 0.0008 0.0297 acetyltransferase) EFHD1 EF-hand domain family, member D1 -2.01 0.0002 0.0172 SSTR1 receptor 1 -1.99 0.0001 0.0146 ficolin (collagen/fibrinogen domain containing FCN2 -1.99 0.0000 0.0114 lectin) 2 (hucolin) FAM84A family with sequence similarity 84, member A -1.99 0.0032 0.0496 lanosterol synthase (2,3-oxidosqualene- LSS -1.97 0.0008 0.0300 lanosterol cyclase) RORC RAR-related C -1.97 0.0011 0.0331 sema domain, immunoglobulin domain (Ig), SEMA4G -1.97 0.0005 0.0259 transmembrane domain (TM) and short cyt ACACB acetyl-Coenzyme A carboxylase beta -1.97 0.0005 0.0240 dihydroxyacetone kinase 2 homolog (S. DAK -1.97 0.0027 0.0466 cerevisiae) PLG plasminogen -1.96 0.0015 0.0365 protein kinase, AMP-activated, beta 2 non- PRKAB2 -1.96 0.0016 0.0375 catalytic subunit KLB klotho beta -1.95 0.0001 0.0130 solute carrier family 6 (neurotransmitter SLC6A1 -1.95 0.0016 0.0373 transporter, GABA), member 1 ODZ1 odz, odd Oz/ten-m homolog 1(Drosophila) -1.94 0.0008 0.0300 C5orf4 chromosome 5 open reading frame 4 -1.92 0.0005 0.0248 haloacid dehalogenase-like hydrolase domain HDHD3 -1.88 0.0012 0.0335 containing 3 Proline rich Gla (G-carboxyglutamic acid) 4 PRRG4 -1.88 0.0008 0.0296 (transmembrane) CHAD chondroadherin -1.88 0.0002 0.0200 TMEM139 transmembrane protein 139 -1.88 0.0010 0.0314 aldo-keto reductase family 1, member D1 AKR1D1 -1.87 0.0000 0.0116 (delta 4-3-ketosteroid-5-beta-reductase) ZBTB20 zinc finger and BTB domain containing 20 -1.87 0.0028 0.0471 KIAA1161 KIAA1161 -1.87 0.0023 0.0436 11/29/2010 Rubbia-Brandt et al. 21 C2orf82 chromosome 2 open reading frame 82 -1.86 0.0013 0.0349 guanine nucleotide binding protein (G GNAO1 -1.86 0.0003 0.0205 protein), alpha activating activity polype PITPNM3 PITPNM family member 3 -1.86 0.0000 0.0065 SKAP1 src kinase associated phosphoprotein 1 -1.86 0.0006 0.0261 solute carrier family 16, member 10 (aromatic SLC16A10 -1.86 0.0006 0.0270 amino acid transporter) beta-1,3-glucuronyltransferase 1 B3GAT1 -1.86 0.0002 0.0189 (glucuronosyltransferase P) C8orf46 chromosome 8 open reading frame 46 -1.85 0.0008 0.0291 FGFR4 fibroblast growth factor receptor 4 -1.85 0.0001 0.0130 GOLGA2L1 golgi autoantigen, golgin subfamily a, 2-like 1 -1.85 0.0002 0.0197 CLEC4G C-type lectin domain family 4, member G -1.85 0.0003 0.0223 protein phosphatase 1, regulatory (inhibitor) PPP1R16A -1.85 0.0025 0.0450 subunit 16A family with sequence similarity 149, member FAM149A -1.85 0.0001 0.0153 A SLC25A42 solute carrier family 25, member 42 -1.85 0.0001 0.0130 WDR5B WD repeat domain 5B -1.84 0.0001 0.0151 ATP6V0E2 ATPase, H+ transporting V0 subunit e2 -1.84 0.0002 0.0171 carbohydrate (chondroitin 4) sulfotransferase CHST13 -1.84 0.0021 0.0421 13 DAO D-amino-acid oxidase -1.83 0.0002 0.0200 CDON Cdon homolog (mouse) -1.83 0.0025 0.0449 SNED1 sushi, nidogen and EGF-like domains 1 -1.83 0.0000 0.0093 ZNF238 zinc finger protein 238 -1.83 0.0026 0.0458 Ras association (RalGDS/AF-6) and pleckstrin RAPH1 -1.83 0.0031 0.0489 homology domains 1 N-acyl phosphatidylethanolamine NAPEPLD -1.83 0.0021 0.0422 phospholipase D C14orf132 chromosome 14 open reading frame 132 -1.83 0.0001 0.0153 ZMYND12 zinc finger, MYND-type containing 12 -1.82 0.0000 0.0066 GPER G protein-coupled 1 -1.82 0.0022 0.0430 CLMN calmin (calponin-like, transmembrane) -1.81 0.0022 0.0431 TMEM37 transmembrane protein 37 -1.81 0.0000 0.0087 PTH1R parathyroid hormone 1 receptor -1.80 0.0000 0.0087 CLDN14 claudin 14 -1.80 0.0010 0.0314 cytochrome P450, family 3, subfamily A, CYP3A43 -1.80 0.0021 0.0415 polypeptide 43 CLCN5 chloride channel 5 -1.79 0.0007 0.0286 GLYCTK glycerate kinase -1.79 0.0013 0.0346 solute carrier organic anion transporter family, SLCO4C1 -1.79 0.0000 0.0079 member 4C1 connector enhancer of kinase suppressor of CNKSR2 -1.78 0.0017 0.0384 Ras 2 PKLR pyruvate kinase, liver and RBC -1.78 0.0007 0.0283 11/29/2010 Rubbia-Brandt et al. 22 CDC14 cell division cycle 14 homolog B (S. CDC14B -1.77 0.0026 0.0453 cerevisiae) JMJD5 jumonji domain containing 5 -1.76 0.0020 0.0411 EXPH5 exophilin 5 -1.76 0.0008 0.0300 STAB2 stabilin 2 -1.76 0.0011 0.0321 glycine C-acetyltransferase (2-amino-3- GCAT -1.75 0.0000 0.0114 ketobutyrate coenzyme A ligase) glycerol-3-phosphate dehydrogenase 1 GPD1 -1.75 0.0003 0.0205 (soluble) family with sequence similarity 117, member FAM117A -1.75 0.0028 0.0473 A ACVR1C activin A receptor, type IC -1.75 0.0030 0.0483 SEC14L4 SEC14-like 4 (S. cerevisiae) -1.74 0.0024 0.0440 ACOX2 acyl-Coenzyme A oxidase 2, branched chain -1.74 0.0019 0.0404 NCKAP5 NCK-associated protein 5 -1.74 0.0002 0.0192 LOC283481 hypothetical protein LOC283481 -1.74 0.0004 0.0226 EPB41L5 erythrocyte membrane protein band 4.1 like 5 -1.74 0.0021 0.0422 SLC47A1 solute carrier family 47, member 1 -1.73 0.0001 0.0138 StAR-related lipid transfer (START) domain STARD10 -1.73 0.0006 0.0274 containing 10 C12orf69 chromosome 12 open reading frame 69 -1.73 0.0003 0.0223 RHBG Rh family, B glycoprotein (gene/pseudogene) -1.73 0.0000 0.0065 protein kinase, AMP-activated, gamma 2 non- PRKAG2 -1.72 0.0030 0.0487 catalytic subunit C6orf124 chromosome 6 open reading frame 124 -1.71 0.0003 0.0221 neighbor of BRCA1 gene 2 (non-protein NBR2 -1.71 0.0004 0.0226 coding) AR -1.71 0.0012 0.0342 IMP1 inner mitochondrial membrane IMMP1L -1.71 0.0006 0.0263 peptidase-like (S. cerevisiae) nuclear receptor subfamily 1, group I, member NR1I2 -1.71 0.0016 0.0375 2 carboxymethylenebutenolidase homolog CMBL -1.71 0.0004 0.0224 (Pseudomonas) Acyl-CoA synthetase long-chain family ACSL6 -1.71 0.0005 0.0246 member 6 hCG_2008140 hypothetical LOC729614 -1.71 0.0027 0.0462 RGNEF Rho-guanine nucleotide exchange factor -1.71 0.0016 0.0376 alcohol dehydrogenase 4 (class II), pi ADH4 -1.71 0.0008 0.0290 polypeptide FTCD formiminotransferase cyclodeaminase -1.70 0.0013 0.0352 SH3PXD2A SH3 and PX domains 2A -1.70 0.0020 0.0407 solute carrier family 6 (neurotransmitter SLC6A13 -1.70 0.0015 0.0365 transporter, GABA), member 13 ALDH1L1 aldehyde dehydrogenase 1 family, member L1 -1.70 0.0003 0.0205 CROT carnitine O-octanoyltransferase -1.70 0.0031 0.0489 11/29/2010 Rubbia-Brandt et al. 23 KLF9 Kruppel-like factor 9 -1.70 0.0012 0.0335 KLHDC1 kelch domain containing 1 -1.70 0.0004 0.0234 SLC38A3 solute carrier family 38, member 3 -1.70 0.0031 0.0495 GRB14 growth factor receptor-bound protein 14 -1.69 0.0016 0.0368 SUOX sulfite oxidase -1.69 0.0018 0.0388 NHSL1 NHS-like 1 -1.69 0.0024 0.0442 cytochrome P450, family 4, subfamily F, CYP4F3 -1.69 0.0003 0.0220 polypeptide 3 LRRN3 leucine rich repeat neuronal 3 -1.69 0.0022 0.0431 spermidine/spermine N1-acetyltransferase SAT2 -1.69 0.0015 0.0365 family member 2 ENOSF1 enolase superfamily member 1 -1.69 0.0024 0.0445 A2LD1 AIG2-like domain 1 -1.68 0.0001 0.0130 C12orf72 chromosome 12 open reading frame 72 -1.68 0.0001 0.0165 ATXN7L1 ataxin 7-like 1 -1.68 0.0002 0.0203 calcineurin-like phosphoesterase domain CPPED1 -1.68 0.0000 0.0130 containing 1 PDE4DIP phosphodiesterase 4D interacting protein -1.68 0.0000 0.0092 SIK2 salt-inducible kinase 2 -1.68 0.0003 0.0205 solute carrier family 25 (mitochondrial carrier; SLC25A10 -1.68 0.0001 0.0168 dicarboxylate transporter), mem GFRA1 GDNF family receptor alpha 1 -1.68 0.0001 0.0130 TCEA3 transcription elongation factor A (SII), 3 -1.68 0.0008 0.0300 NCRNA00086 non-protein coding RNA 86 /// non-protein /// -1.67 0.0014 0.0361 coding RNA 87 NCRNA00087 echinoderm microtubule associated protein EML6 -1.67 0.0016 0.0369 like 6 CBARA1 calcium binding atopy-related autoantigen 1 -1.67 0.0021 0.0421 TMEM97 transmembrane protein 97 -1.67 0.0030 0.0484 OSBPL6 oxysterol binding protein-like 6 -1.67 0.0014 0.0359 synovial sarcoma, X breakpoint 2 interacting SSX2IP -1.67 0.0007 0.0282 protein FANCC Fanconi anemia, complementation group C -1.67 0.0002 0.0194 SCRN2 secernin 2 -1.66 0.0002 0.0189 FAM85A family with sequence similarity 85, member A -1.66 0.0002 0.0173 AK3L1 adenylate kinase 3-like 1 -1.66 0.0012 0.0342 ADH6 alcohol dehydrogenase 6 (class V) -1.66 0.0020 0.0411 solute carrier family 25 (mitochondrial carrier; SLC25A23 -1.66 0.0009 0.0304 phosphate carrier), member 23 FLJ39653 hypothetical FLJ39653 -1.66 0.0030 0.0488 LOC100287552 PNAS-119 -1.66 0.0002 0.0204 KIAA0427 KIAA0427 -1.66 0.0005 0.0259 ST3GAL1 ST3 beta-galactoside alpha-2,3- -1.66 0.0015 0.0362 11/29/2010 Rubbia-Brandt et al. 24 sialyltransferase 1 CES7 carboxylesterase 7 -1.65 0.0017 0.0387 C21orf34 open reading frame 34 -1.65 0.0005 0.0247 ANXA9 annexin A9 -1.65 0.0005 0.0239 KIAA1683 KIAA1683 -1.65 0.0002 0.0181 insulin-like growth factor binding protein, acid IGFALS -1.65 0.0016 0.0372 labile subunit TTC36 tetratricopeptide repeat domain 36 -1.65 0.0001 0.0153 patatin-like phospholipase domain containing PNPLA7 -1.64 0.0007 0.0283 7 CA5A carbonic anhydrase VA, mitochondrial -1.64 0.0014 0.0355 ZNF680 zinc finger protein 680 -1.64 0.0018 0.0396 TM6SF2 transmembrane 6 superfamily member 2 -1.64 0.0001 0.0130 PAIP2B poly(A) binding protein interacting protein 2B -1.64 0.0001 0.0168 SCLY selenocysteine -1.64 0.0015 0.0361 CNTNAP2 contactin associated protein-like 2 -1.64 0.0019 0.0404 SLC46A3 solute carrier family 46, member 3 -1.64 0.0003 0.0213 FOXP2 forkhead box P2 -1.64 0.0014 0.0360 Rho family GTPase 2 -1.64 0.0016 0.0376 FMO4 flavin containing monooxygenase 4 -1.63 0.0021 0.0424 solute carrier family 46 (folate transporter), SLC46A1 -1.63 0.0000 0.0109 member 1 RAD54L2 RAD54-like 2 (S. cerevisiae) -1.63 0.0004 0.0224 LOC285986 hypothetical protein LOC285986 -1.63 0.0029 0.0477 UPB1 ureidopropionase, beta -1.63 0.0002 0.0171 CAPN5 calpain 5 -1.63 0.0015 0.0361 peroxisome proliferator-activated receptor PPARA -1.62 0.0009 0.0310 alpha RBP5 retinol binding protein 5, cellular -1.62 0.0001 0.0130 nerve growth factor receptor (TNFR NGFR -1.62 0.0006 0.0265 superfamily, member 16) PRKCZ protein kinase C, zeta -1.61 0.0007 0.0281 LOC284440 hypothetical LOC284440 -1.61 0.0012 0.0339 GJB1 gap junction protein, beta 1, 32kDa -1.61 0.0007 0.0285 VIPR1 vasoactive intestinal peptide receptor 1 -1.61 0.0011 0.0326 cytochrome P450, family 3, subfamily A, CYP3A5 -1.61 0.0016 0.0369 polypeptide 5 TSPAN12 tetraspanin 12 -1.61 0.0031 0.0495 IQSEC1 IQ motif and Sec7 domain 1 -1.61 0.0002 0.0171 CUL5 cullin 5 -1.60 0.0002 0.0197 FBXL4 F-box and leucine-rich repeat protein 4 -1.60 0.0002 0.0174 SELENBP1 selenium binding protein 1 -1.60 0.0002 0.0184 ectonucleotide ENPP1 -1.60 0.0002 0.0201 pyrophosphatase/phosphodiesterase 1 PCYT2 phosphate cytidylyltransferase 2, -1.59 0.0003 0.0221 11/29/2010 Rubbia-Brandt et al. 25 ethanolamine hCG_1811732 hypothetical LOC151534 -1.59 0.0012 0.0335 tumor necrosis factor, alpha-induced protein TNFAIP8L1 -1.59 0.0013 0.0346 8-like 1 LOC257396 hypothetical protein LOC257396 -1.59 0.0004 0.0224 ASB4 ankyrin repeat and SOCS box-containing 4 -1.59 0.0009 0.0303 QDPR Quinoid dihydropteridine reductase -1.59 0.0022 0.0426 C11orf71 chromosome 11 open reading frame 71 -1.58 0.0001 0.0131 CTTNBP2 cortactin binding protein 2 -1.58 0.0001 0.0152 KIF22 kinesin family member 22 -1.58 0.0004 0.0228 DHFR dihydrofolate reductase -1.58 0.0010 0.0313 C14orf73 chromosome 14 open reading frame 73 -1.58 0.0007 0.0281 Transcription factor Dp-2 (E2F dimerization TFDP2 -1.58 0.0001 0.0163 partner 2) HFE2 hemochromatosis type 2 (juvenile) -1.57 0.0004 0.0235 ARSD arylsulfatase D -1.57 0.0014 0.0360 sulfotransferase family, cytosolic, 1A, phenol- SULT1A2 -1.57 0.0012 0.0332 preferring, member 2 NFIA /A -1.57 0.0004 0.0237 DIO1 deiodinase, iodothyronine, type I -1.57 0.0002 0.0184 C1orf175 /// chromosome 1 open reading frame 175 /// -1.57 0.0005 0.0243 TTC4 tetratricopeptide repeat domain 4 FGFR3 fibroblast growth factor receptor 3 -1.57 0.0018 0.0389 RICS Rho GTPase-activating protein -1.57 0.0017 0.0380 FOXN2 forkhead box N2 -1.56 0.0031 0.0495 aldo-keto reductase family 7, member A3 AKR7A3 -1.56 0.0000 0.0071 (aflatoxin aldehyde reductase) MUM1 melanoma associated antigen (mutated) 1 -1.56 0.0009 0.0311 dopachrome tautomerase (dopachrome delta- DCT -1.56 0.0007 0.0287 isomerase, tyrosine-related protein 2) TSPYL4 TSPY-like 4 -1.56 0.0015 0.0362 LOC439911 hypothetical gene supported by NM_194304 -1.56 0.0002 0.0202 C9orf95 chromosome 9 open reading frame 95 -1.56 0.0000 0.0120 ESPN espin -1.56 0.0001 0.0159 BMPER BMP binding endothelial regulator -1.56 0.0007 0.0282 phosphatidylinositol glycan anchor PIGV -1.55 0.0001 0.0152 biosynthesis, class V FLJ33996 hypothetical protein FLJ33996 -1.55 0.0004 0.0225 methylmalonic aciduria (cobalamin deficiency) MMAB -1.55 0.0024 0.0439 cblB type PVALB parvalbumin -1.55 0.0010 0.0314 cytochrome P450, family 4, subfamily F, CYP4F12 -1.55 0.0003 0.0207 polypeptide 12 LOC255512 hypothetical protein LOC255512 -1.55 0.0003 0.0223 LRRK2 leucine-rich repeat kinase 2 -1.55 0.0029 0.0481 11/29/2010 Rubbia-Brandt et al. 26 TMEM120A transmembrane protein 120A -1.55 0.0001 0.0130 KIAA1958 KIAA1958 -1.55 0.0026 0.0456 SCAI suppressor of cancer cell invasion -1.55 0.0003 0.0215 dehydrogenase/reductase (SDR family) DHRS1 -1.55 0.0024 0.0440 member 1 KIAA1147 KIAA1147 -1.55 0.0006 0.0275 ATP-binding cassette, sub-family C ABCC6 -1.55 0.0019 0.0402 (CFTR/MRP), member 6 ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -1.55 0.0010 0.0314 carnosine dipeptidase 1 (metallopeptidase CNDP1 -1.55 0.0008 0.0297 M20 family) ABHD1 abhydrolase domain containing 1 -1.54 0.0002 0.0174 PMS2L1 /// postmeiotic segregation increased 2-like 1 -1.54 0.0001 0.0165 PMS2L5 pseudogene /// postmeiotic segregatio sulfotransferase family, cytosolic, 1A, phenol- SULT1A1 -1.54 0.0014 0.0359 preferring, member 1 BDH2 3-hydroxybutyrate dehydrogenase, type 2 -1.54 0.0002 0.0174 family with sequence similarity 168, member FAM168A -1.54 0.0002 0.0181 A Transient receptor potential cation channel, TRPM7 -1.54 0.0023 0.0436 subfamily M, member 7 NCAM2 neural cell adhesion molecule 2 -1.54 0.0015 0.0361 protein phosphatase 1, regulatory (inhibitor) PPP1R3E -1.54 0.0025 0.0450 subunit 3E ATP-binding cassette, sub-family C ABCC6 /// (CFTR/MRP), member 6 /// hypothetical -1.53 0.0018 0.0388 LOC100292715 protein RFNG O-fucosylpeptide 3-beta-N- RFNG -1.53 0.0004 0.0227 acetylglucosaminyltransferase ATPase, H+ transporting, lysosomal accessory ATP6AP1L -1.53 0.0014 0.0360 protein 1-like dopa decarboxylase (aromatic L-amino acid DDC -1.53 0.0008 0.0295 decarboxylase) ALAD aminolevulinate, delta-, dehydratase -1.53 0.0001 0.0168 ADCY10 adenylate cyclase 10 (soluble) -1.53 0.0021 0.0417 erythroblast membrane-associated protein ERMAP -1.53 0.0004 0.0234 (Scianna blood group) SORD sorbitol dehydrogenase -1.53 0.0005 0.0247 solute carrier family 39 (metal ion SLC39A5 -1.53 0.0006 0.0263 transporter), member 5 ADHFE1 alcohol dehydrogenase, iron containing, 1 -1.53 0.0010 0.0314 GARNL3 GTPase activating Rap/RanGAP domain-like 3 -1.53 0.0005 0.0258 PROX1 Prospero homeobox 1 -1.52 0.0029 0.0477 MXI1 MAX interactor 1 -1.52 0.0007 0.0283 UROC1 urocanase domain containing 1 -1.52 0.0014 0.0356 ANO1 anoctamin 1, calcium activated chloride -1.52 0.0007 0.0287 11/29/2010 Rubbia-Brandt et al. 27 channel COQ10A coenzyme Q10 homolog A (S. cerevisiae) -1.52 0.0005 0.0242 EBP emopamil binding protein (sterol isomerase) -1.52 0.0018 0.0398 ANKRD46 ankyrin repeat domain 46 -1.52 0.0000 0.0127 ASXL3 additional sex combs like 3 (Drosophila) -1.52 0.0015 0.0361 ZG16 zymogen granule protein 16 homolog (rat) -1.52 0.0017 0.0384 MAVS mitochondrial antiviral signaling protein -1.52 0.0000 0.0130 TPCN2 Two pore segment channel 2 -1.52 0.0016 0.0372 cytochrome P450, family 39, subfamily A, CYP39A1 -1.51 0.0010 0.0313 polypeptide 1 KLKB1 kallikrein B, plasma (Fletcher factor) 1 -1.51 0.0008 0.0300 TTC18 tetratricopeptide repeat domain 18 -1.51 0.0020 0.0412 C1orf21 chromosome 1 open reading frame 21 -1.51 0.0014 0.0355 LOC729970 similar to hCG2028352 -1.51 0.0024 0.0445 amylo-1, 6-glucosidase, 4-alpha- AGL -1.51 0.0001 0.0159 glucanotransferase pterin-4 alpha-carbinolamine PCBD2 dehydratase/dimerization of -1.51 0.0000 0.0057 hepatocyte nuc GRLF1 DNA binding factor 1 -1.51 0.0019 0.0398 GBA3 glucosidase, beta, acid 3 (cytosolic) -1.51 0.0002 0.0171 GCDH glutaryl-Coenzyme A dehydrogenase -1.51 0.0001 0.0130 RCOR3 REST corepressor 3 -1.51 0.0022 0.0427 BCHE butyrylcholinesterase -1.51 0.0004 0.0226 tissue factor pathway inhibitor (lipoprotein- TFPI -1.50 0.0002 0.0196 associated coagulation inhibitor) calcium channel, voltage-dependent, T type, CACNA1H -1.50 0.0000 0.0079 alpha 1H subunit C10orf58 chromosome 10 open reading frame 58 -1.50 0.0001 0.0159

Table S3: analysis: main genes Fold- adjusted p-value Change p-value Gene Symbol Name (SOS vs. (SOS vs. (SOS vs. Control) Control) Control) Acute phase response signaling and CRP C-reactive protein 4.01 0.0127 0.0339 SOD2 superoxide dismutase 2, mitochondrial 3.50 0.0003 0.0205 LBP lipopolysaccharide binding protein 2.52 0.0010 0.0320 SOCS1 suppressor of cytokine signaling 1 2.27 0.0089 0.0491 interleukin 6 signal transducer (gp130, IL6ST 2.13 0.0120 0.0313 oncostatin M receptor) 11/29/2010 Rubbia-Brandt et al. 28 signal transducer and activator of transcription STAT3 1.87 0.0003 0.0221 3 IL6 interleukin 6 1.52 0.0804 0.02480

Table S4: Gene ontology analysis: main genes

Fold- adjusted p-value Change p-value Gene Symbol Name (SOS vs. (SOS vs. (SOS vs. Control) Control) Control) Coagulation cascade system serpin peptidase inhibitor, clade E (nexin, SERPINE1 3.04 0.0018 0.0390 plasminogen activator inhibitor type VWF von Willebrand factor 3.07 0.0000 0.0110 THBD thrombomodulin 2.13 0.0000 0.0130 F3 coagulation factor III 1.35 0.0032 0.0501 PLAU plasminogen activator, urokinase 1.34 0.0026 0.0459

Table S5: Gene ontology analysis: main genes Fold- adjusted p-value Change p-value Gene Symbol Name (SOS vs. (SOS vs. (SOS vs. Control) Control) Control) Hepatic fibrosis/hepatic stellate cell activation COL15A1 collagen, type XV, alpha 1 5.42 0.0000 0.0057 COL1A2 collagen, type I, alpha 2 3.48 0.0001 0.0157 COL1A1 collagen, type I, alpha 1 3.03 0.0002 0.0171 COL4A1 collagen, type IV, alpha 1 2.92 0.0000 0.0057 CCL2 chemokine (C-C motif) ligand 2 2.80 0.0009 0.0304 THBS2 thrombospondin 2 2.68 0.0000 0.0057 THBS1 thrombospondin 1 2.58 0.0017 0.0379 LBP lipopolysaccharide binding protein 2.52 0.0010 0.0320 TIMP1 TIMP metallopeptidase inhibitor 1 2.26 0.0000 0.0109 LUM lumican 2.25 0.0004 0.0224 FBN1 fibrillin 1 2.22 0.0003 0.0221 IFNGR1 interferon gamma receptor 1 2.16 0.0006 0.0276 COL3A1 collagen, type III, alpha 1 2.12 0.0004 0.0223 11/29/2010 Rubbia-Brandt et al. 29 platelet-derived growth factor receptor, alpha PDGFRA 1.87 0.0003 0.0205 polypeptide platelet-derived growth factor alpha PDGFA 1.80 0.0044 0.0506 polypeptide MMP2 matrix metallopeptidase 2 1.52 0.0003 0.0223 MMP7 matrix metallopeptidase 7 1.26 0.0218 0.1233 MMP9 matrix metallopeptidase 9 1.02 0.9062 0.9516

Table S6: Gene ontology analysis: main genes Fold- adjusted p-value Change p-value Gene Symbol Name (SOS vs. (SOS vs. (SOS vs. Control) Control) Control) Cytokines and chemokines, inflammatory pathway CCL20 chemokine (C-C motif) ligand 20 10.97 0.0001 0.0142 CCL2 chemokine (C-C motif) ligand 2 2.80 0.0009 0.0304 IL32 interleukin 32 2.72 0.0006 0.0276 IFNGR1 interferon gamma receptor 1 2.16 0.0006 0.0276 CCL19 chemokine (C-C motif) ligand 19 1.88 0.0013 0.0349 signal transducer and activator of transcription STAT1 1.87 0.0003 0.0206 1, 91kDa IL1RN interleukin 1 receptor antagonist 1.70 0.0172 0.1092 CCL5 chemokine (C-C motif) ligand 5 1.56 0.0042 0.0564 CCL21 chemokine (C-C motif) ligand 21 1.48 0.0050 0.0608 IFNGR2 interferon gamma receptor 2 1.34 0.0036 0.0529 signal transducer and activator of transcription STAT2 1.05 0.1596 0.3625 2, 113kDa

Table S7: Gene ontology analysis: main genes Fold- adjusted p-value Change p-value Gene Symbol Name (SOS vs. (SOS vs. (SOS vs. Control) Control) Control) Cytochrome P450 panel cytochrome P450, family 7, subfamily A, CYP7A1 -5.36 0.0016 0.0369 polypeptide 1 cytochrome P450, family 2, subfamily C, CYP2C19 -2.98 0.0041 0.0559 polypeptide 19 cytochrome P450, family 2, subfamily D, CYP2D6 -1.83 0.0151 0.1024 polypeptide 6 11/29/2010 Rubbia-Brandt et al. 30 cytochrome P450, family 3, subfamily A, CYP3A43 -1.80 0.0021 0.0415 polypeptide 43 cytochrome P450, family 39, subfamily A, CYP39A1 -1.51 0.0010 0.0313 polypeptide 1 cytochrome P450, family 46, subfamily A, CYP46A1 -1.43 0.0040 0.0555 polypeptide 1