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2009 Tomos 05 Teyxos 1.Pdf E§§HNIKH HELLENIC ETAIPEIA SOCIETY OF ANO™O§O°IA™ IMMUNOLOGY ′ αTPIMHNIAIAνοσια EK¢O™H TH™ E§§HNIKH™ ETAIPEIA™ ANO™O§O°IA™ TOMO™ 5, TEYXO™ 1 ñ 2009 ISSN 1790-6490 anosia QUARTERLY EDITION OF THE HELLENIC SOCIETY OF IMMUNOLOGY VOLUME 5, NUMBER 1 ñ 2009 E§§HNIKH ETAIPEIA ANO™O§O°IA™ TPIMHNIAIA EK¢O™H ISSN 1790-6490 TOMO™ 5 ñ TEYXO™ 1 TH™ E§§HNIKH™ ETAIPEIA™ ANO™O§O°IA™ ª·È¿Ó‰ÚÔ˘ 23, 115 28 ∞ı‹Ó· | ΔËÏ. +30 210 7211845 | F·¯: +30 210 7215082 | ÂÚȯfiÌÂÓ· E-mail: [email protected] | http: //www.helsim.gr ¢IOIKHTIKO ™YMBOY§IO E.E.A. ¶Úfi‰ÚÔ˜ : X. NÈÎÔÏ¿Ô˘ AÓÙÈÚfi‰ÚÔ˜ : ¶. MÔ‡Ú· To ·ÚÂÏıfiÓ Î·È ÙÔ Ì¤ÏÏÔÓ Ù˘ ÂÈÛÙ‹Ì˘ Ù˘ ∞ÓÔÛÔÏÔÁ›·˜ °ÂÓ. °Ú·ÌÌ·Ù¤·˜ : A. TÛÈÚÔÁÈ¿ÓÓË Ã. ¡ÈÎÔÏ¿Ô˘ .............................................................................................................................. 15 Eȉ. °Ú·ÌÌ·Ù¤·˜ : ¶. ™Î¤Ó‰ÚÔ˜ T·Ì›·˜ : X. ÕÓÙ˙Ô˘-AÁÁÔ˘Úȉ¿ÎË ∞ÓÔÛÔÏÔÁ›· Ù˘ Ïԛ̈͢ M¤ÏË : ª. μ¿ÚÏ·-§Â˘ıÂÚÈÒÙË ª. ™˘ÚÔÔ‡ÏÔ˘ Ã. ÕÓÙ˙Ô˘-∞ÁÁÔ˘Úȉ¿ÎË .......................................................................................................... 19 ™YNTAKTIKH E¶ITPO¶H ¶Úfi‰ÚÔ˜ : ¶. MÔ‡Ú· ÃÚfiÓȘ ÂÓ‰Ô΢ÙÙ¿ÚȘ ÏÔÈÌÒÍÂȘ: Y‡ı˘ÓÔÈ Û‡ÓÙ·Í˘ ÙÔ ·Ú¿‰ÂÈÁÌ· Ù˘ ‚ÚԢΤÏψÛ˘ X. NÈÎÔÏ¿Ô˘ ¶. ™Î¤Ó‰ÚÔ˜ ............................................................................................................................. 22 º. ¶·ÏËÔÁÈ¿ÓÓË A. TÛÈÚÔÁÈ¿ÓÓË ∂Ì‚fiÏÈ·: ¶ÚÔ‚ÏËÌ·ÙÈÛÌÔ› Î·È ÚÔÔÙÈΤ˜ O. MˆÚ·ÏfiÁÏÔ˘-MÂÓ¤ÙÔ˘ X. ÕÓÙ˙Ô˘-AÁÁÔ˘Úȉ¿ÎË ª. ÷Ù˙ËÛÙ˘ÏÈ·ÓÔ‡-™È‰ËÚÔÔ‡ÏÔ˘ ...................................................................................... 27 £. KÂÚ·ÌÈÙÛfiÁÏÔ˘ ∂ÈÛ·ÁˆÁ‹ ÛÙËÓ ·˘ÙÔ·ÓÔÛ›· ™YMBOY§EYTIKH E¶ITPO¶H † M. ¶·˘Ï¿ÙÔ˘ ∞. ™·Ú·ÓÙfiÔ˘ÏÔ˜ ................................................................................................................... 31 M. B¿ÚÏ·-§Â˘ıÂÚÈÒÙË °. 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ΔÛ¤ÏÈÔ˜ I. °ÎÔ˘ÁÎÔ˘Ú¤Ï·˜ ∞ÁÁÂȷ΋ ÊÏÂÁÌÔÓ‹ ÛÙËÓ ˘¤ÚÙ·ÛË Î·È ÙÔÓ Û·Î¯·ÚÒ‰Ë ‰È·‚‹ÙË Y¶OBO§H AP£PøN-™YN¢POME™ ∫. ¶·Ï¤Ù·˜ ................................................................................................................................ 57 °È· ÙÔ ÂÚÈÔ‰ÈÎfi ¶. ªÔ‡Ú· ∞Ó›¯Ó¢ÛË ·˘ÙÔ·ÓÙÈÛˆÌ¿ÙˆÓ ¤Ó·ÓÙÈ Ù˘ Ì˘ÔÛ›Ó˘ Û ·ÛıÂÓ›˜ ΔÌ‹Ì· ∫ÏÈÓÈ΋˜ ∞ÓÔÛÔÏÔÁ›·˜ μ′ ¶·ıÔÏÔÁÈ΋˜ ∫ÏÈÓÈ΋˜ ∞¶£ πÔÎÚ¿ÙÂÈÔ °.¶.N.£. | ∫ˆÓÛÙ·ÓÙÈÓÔ˘fiψ˜ 49 Ì ηÚΛÓÔ ÙÔ˘ ·¯¤Ô˜ ÂÓÙ¤ÚÔ˘ 546 42 £ÂÛÛ·ÏÔÓ›ÎË | TËÏ. 2310 892239 & 2310 992810 e-mail: [email protected] ∑. ¶·ÏÏ·ÓÙ˙¿, ª. ¡ÈÎÔÏÔÔ‡ÏÔ˘, ¡. ª¤ÌÔ˜, ∞. ∫·Ù¿ÎË, ° . ∫·Ú·ÓÙ˙›ÎÔ˜, EÙ‹ÛÈ· Û˘Ó‰ÚÔÌ‹ € 30,00 ¡. ∞ÏÂÍ·Ó‰ÚfiÔ˘ÏÔ˜, °. ¶·Ó¤ÙÛÔ˜, ª. ∫ˆÓÛÙ·ÓÙÔ˘Ï¿Î˘ ............................................ 63 Y¶EY£YNO™ TY¶O°PAºEIOY-¢IAºHMI™EøN UNIVERSITY STUDIO PRESS §ÂˆÓ›‰·˜ A. Mȯ¿Ï˘ AÚÌÂÓÔÔ‡ÏÔ˘ 32, 546 35 £ÂÛÛ·ÏÔÓ›ÎË TËÏ. 2310 209637, 2310 209837, Fax 2310 216647 ºˆÙÔÁÚ·Ê›· Â͈ʇÏÏÔ˘: ¶ÚÒÈÌÔ ÛÙ¿‰ÈÔ ·ÁÁÂȷ΋˜ ÊÏÂÁÌÔÓ‹˜ ÛÙÔÓ Û·Î¯·ÚÒ‰Ë ‰È·‚‹ÙË. §ÂÌÊÔ΢ÙÙ·ÚÈ΋ E-mail: [email protected] ‰È‹ıËÛË ¯ˆÚ›˜ ·ÏÏÔ›ˆÛË ÙˆÓ ·ÁÁÂÈ·ÎÒÓ ÏÂÈÙÔ˘ÚÁÈÎÒÓ ·Ó·ÙÔÌÈÎÒÓ ÛÙÔȯ›ˆÓ. HELLENIC SOCIETY OF anosia IMMUNOLOGY TRIMESTRAL EDITION OF ISSN 1790-6490 VOLUME 5 NUMBER 1 THE HELLENIC SOCIETY OF IMMUNOLOGY ñ Meandrou 23, 115 28 Athens | Tel. + 30 210 7211845 | F·¯: + 30 210 7215082 | contents E-mail: [email protected] | http: //www.helsim.gr BOARD OF H.S.I. President : Ch. Nikolaou Vice President : P. Boura Past and future of Immunology General Secretary: A. Tsiroyianni Ch. ¡icolaou ............................................................................................................................. 15 Specific Secretary: P. Skendros Treasurer : Ch. Antzou-Agouridaki Immunology of infections Members : M. Varla-Leftherioti M. Spiropoulou Ch. Antzou-Agouridaki ............................................................................................................ 19 EDITORIAL BOARD Editor in Chief : P. Boura Chronic intracellular infections: the paradigm of brucellosis Co-editors P. Skendros ............................................................................................................................... 22 Ch. Nikolaou F. Palioyianni Vaccines: Arising questions and prospectives A. Tsiroyianni ª. Xatzistilianou-Sidiropoulou .............................................................................................. 27 O. Moraloglou-Benetou Ch. Antzou-Agouridaki Introduction to Autoimmunity Th. Keramitsoglou ∞. Sarantopoulos ...................................................................................................................... 31 ADVISORY COMMITTEE † M. Pavlatou Systemic Autoimmune diseases: The paradigm of Rheumatoid M. Daniilidis I. Ekonomidou Arthritis and Systemic Lupus Erythematosus E. Kaklamani ∫. Tselios ................................................................................................................................... 35 F. Kanakoudi-Tsakalidou G. Kyriazis Organ specific autoimmune diseases A. Manthos Ch. Papasteriadi ∞. Δsirogianni ............................................................................................................................ 38 Z. Polymenidis M. Raptopoulou-Gigi Laboratory approach of autoimmune diseases A. Stavropoulou-Gioka ∞ik. Pavlitou-TsiontsiÈ ............................................................................................................... 43 J. Theodorou M. Varla-Leftherioti Systemic autoinflammatory diseases G. Vergoulas EDITORIAL ASSISTANT COMMITTEE G. Mitroulis, V. Papadopoulos ............................................................................................... 49 A. Sarantopoulos Vascular inflammation in hypertension and in diabetes K. Tselios J. Gougourelas ∫. Paletas ................................................................................................................................... 57 SUBMISSION OF ARTICLES-SUBSCRIPTIONS anosia Autoimmune response against myosin in colorectal P. Boura, editor-in-chief cancer patients Clinical Immunology Unit, 2nd Medical Clinic, Hippokratio Gen. Hospital of Thessaloniki. |49 Konstantinoupoleos Str. ∑. Pallatza, M. Nikolopoulou, N. Memos, A. Kataki, G. Karantzikos, 546 42 Thessaloniki, Greece N. Alexandropoulos, G. Panetsos, M. Kostantoulakis ....................................................... 63 TËÏ. +30 2310 892239 & +30 2310 992810 e-mail: [email protected] Annual subscription € 30,00 PUBLISHER UNIVERSITY STUDIO PRESS Leonidas A. Michalis Armenopoulou 32, 546 35 Thessaloniki Tel. 2310 209637, 2310 209837, Fax 2310 216647 E-mail: [email protected] E¶π™Δ∏ª√¡π∫∏ ∂∫¢∏§ø™∏ °π∞ Δ√¡ ∂√ƒΔ∞™ª√ Δ∏™ ¶∞°∫√™ªπ∞™ ∏ª∂ƒ∞™ ∞¡√™√§√°π∞™ TÔ ·ÚfiÓ Î·È ÙÔ Ì¤ÏÏÔÓ Ù˘ ∞ÓÔÛÔÏÔÁ›·˜ ∂π™∞°ø°∏ To ·ÚÂÏıfiÓ Î·È ÙÔ Ì¤ÏÏÔÓ Ù˘ ÂÈÛÙ‹Ì˘ Ù˘ ∞ÓÔÛÔÏÔÁ›·˜ Ã. ¡ÈÎÔÏ¿Ô˘ ∞¡√™√§√°π∞ §√πªø•∏™ ∞ÓÔÛÔÏÔÁ›· Ù˘ Ïԛ̈͢ Ã. ÕÓÙ˙Ô˘-∞ÁÁÔ˘Úȉ¿ÎË ÃÚfiÓȘ ÂÓ‰Ô΢ÙÙ¿ÚȘ ÏÔÈÌÒÍÂȘ: ÙÔ ·Ú¿‰ÂÈÁÌ· Ù˘ ‚ÚԢΤÏψÛ˘ ¶. ™Î¤Ó‰ÚÔ˜ ∂Ì‚fiÏÈ·: ¶ÚÔ‚ÏËÌ·ÙÈÛÌÔ› Î·È ÚÔÔÙÈΤ˜ ª. ÷Ù˙ËÛÙ˘ÏÈ·ÓÔ‡-™È‰ËÚÔÔ‡ÏÔ˘ ∞ÀΔ√∞¡√™∞ ¡√™∏ª∞Δ∞ ∂ÈÛ·ÁˆÁ‹ ÛÙËÓ ·˘ÙÔ·ÓÔÛ›· ∞. ™·Ú·ÓÙfiÔ˘ÏÔ˜ ™˘ÛÙËÌ·ÙÈο ·˘ÙÔ¿ÓÔÛ· ÓÔÛ‹Ì·Ù·: ÙÔ ·Ú¿‰ÂÈÁÌ· Ù˘ ÚÂ˘Ì·ÙÔÂȉԇ˜ ·ıÚ›Ùȉ·˜ Î·È ÙÔ˘ Û˘ÛÙËÌ·ÙÈÎÔ‡ ÂÚ˘ıËÌ·ÙÒ‰Ô˘˜ χÎÔ˘ ∫. ΔÛ¤ÏÈÔ˜ √ÚÁ·ÓÔÂȉÈο ·˘ÙÔ¿ÓÔÛ· ÓÔÛ‹Ì·Ù· ∞. ΔÛÈÚÔÁÈ¿ÓÓË ∂ÚÁ·ÛÙËÚȷ΋ ÚÔÛ¤ÁÁÈÛË ·˘ÙÔ¿ÓÔÛˆÓ ÚÂ˘Ì·ÙÈÎÒÓ ÓÔÛËÌ¿ÙˆÓ ∞ÈÎ. ¶·˘Ï›ÙÔ˘-ΔÛÈfiÓÙÛË ∂ÈÛ·ÁˆÁ‹ ΔÔ ·ÚÂÏıfiÓ Î·È ÙÔ Ì¤ÏÏÔÓ Ù˘ ÂÈÛÙ‹Ì˘ Ù˘ ∞ÓÔÛÔÏÔÁ›·˜ Ã. ¡ÈÎÔÏ¿Ô˘ æ˘¯È·ÙÚÈ΋ – ¡Â˘ÚÔÏÔÁÈ΋ ∫ÏÈÓÈ΋, ¶·ÓÂÈÛÙËÌÈ·Îfi ¡ÔÛÔÎÔÌÂ›Ô “∞ÈÁÈÓ‹ÁÂÈÔ” ∞ı‹Ó· 2009; 1: 15 – 18 ∏ ·ÓÔÛÔÏÔÁ›· Â›Ó·È ¤Ó·˜ ıÂÌÂÏÈ҉˘ Î·È ÁÔËÙ¢ÙÈÎfi˜ Ù˜ ÂΛӘ ÎÔÈӈӛ˜, ›ÛÙ¢·Ó fiÙÈ ¿ÓıÚˆÔÈ Î·È Ê‡- ÎÏ¿‰Ô˜ Ù˘ È·ÙÚÈ΋˜. ∂›Ó·È Ë ÂÈÛÙ‹ÌË Ô˘ ·Û¯ÔÏÂ›Ù·È ÛË ÏÂÈÙÔ˘ÚÁÔ‡Ó Î¿Ùˆ ·fi ÙȘ Ì·ÁÈΤ˜ ÂÈÚÚÔ¤˜ Ó¢- Ì ÙË ÌÂϤÙË ÙˆÓ Ì˯·ÓÈÛÌÒÓ Ì ÙÔ˘˜ ÔÔ›Ô˘˜ Ô ÔÚ- Ì¿ÙˆÓ, ‰·ÈÌfiÓˆÓ ‹ ÙȘ Ì˘ÛÙÈΤ˜ ÂÈÚÚÔ¤˜ £ÂÒÓ. ™ÙËÓ Á·ÓÈÛÌfi˜ ·Ó·ÁÓˆÚ›˙ÂÈ, ÂÍÔ˘‰ÂÙÂÚÒÓÂÈ Î·È ·ÔÌ·ÎÚ‡- ·Ï·È¿ ‰È·ı‹ÎË, Ô £Âfi˜ ÛÙ¤ÏÓÂÈ ÏÔÈÌÔ‡˜ ˆ˜ ÙÈ̈ڛ· ÓÂÈ Î¿ı ͤÓÔ ÂÈÛ‚ÔϤ·. ªÔÓ·‰ÈÎfi ÔχÙÈÌÔ ÂÊfi‰ÈÔ Û ÂΛÓÔ˘˜ Ô˘ ÙÔÓ Î·Ù··ÙÔ‡Ó ·ÏÏ¿ Î·È ÛÙÔ˘˜ ¯- ÙÔ˘ ÔÚÁ·ÓÈÛÌÔ‡ ÛÙËÓ ·ÓÙÈÌÂÙÒÈÛË ÙˆÓ ÂÈÛ‚ÔϤˆÓ, ıÚÔ‡˜ Ù˘ Ê˘Ï‹˜ ÙÔ˘ ¢·‚›‰, fiˆ˜ Â›Ó·È ÔÈ ∞ÈÁ‡ÙÈÔÈ, Â›Ó·È ÙÔ ·ÓÔÛÈ·Îfi Û‡ÛÙËÌ·, ¤Ó· Û‡ÛÙËÌ· ÔχÏÔÎÔ, ÔÈ ºÈÏÈÛÙ·›ÔÈ Î·È ÔÈ ∞ÛÛ‡ÚÈÔÈ. √È μ·‚˘ÏÒÓÈÔÈ Î·È ÔÈ ¿ÚÈÛÙ· ÔÚÁ·ÓˆÌ¤ÓÔ, ÚÔ˚fiÓ ÌÈ·˜ Ì·ÎÚ¿˜ ÂÍÂÏÈÎÙÈ΋˜ ∞ÈÁ‡ÙÈÔÈ ÁÈ· ÙËÓ ÚÔÛÙ·Û›· ÙÔ˘˜ ÂÚȤϷ‚·Ó ÛÙÔ ÔÚ›·˜, ÙÔ ÔÔ›Ô fiÛÔ Ë ¤Ú¢ӷ ÚÔ¯ˆÚ¿ÂÈ Ì·˜ «¶¿ÓıÂfi» ÙÔ˘˜ Î·È ¤Ó·Ó £Âfi ÁÈ· ÙȘ ·Ûı¤ÓÂȘ. ·ÔηχÙÂÙ·È ÔÏÔ¤Ó· Î·È ÂÚÈÛÛfiÙÂÚÔ Î·È Û˘Ó¯Ҙ √ ÈÛÙÔÚÈÎfi˜ £Ô˘Î˘‰›‰Ë˜, ÛÙÔÓ ·ÔÏÔÁÈÛÌfi ÙÔ˘ Ì·˜ ÂÎÏ‹ÛÛÂÈ Ì ÙȘ ·ÓÂÍ¿ÓÙÏËÙ˜ ‰˘Ó·ÙfiÙËÙ¤˜ ÙÔ˘. 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