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July 2020 Strategies for Emerging Infectious Diseases

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THE AMERICAN WWW.CAYMANCHEM.COM ASSOCIATION OF IMMUNOLOGISTS AT ISSUE NEW THE DOWNLOAD Virus Life Cycle Infographic Infographic Cycle Life Virus JULY 2020 Resources for Your Research Your for Resources Informative Articles Informative CAYMAN CURRENTS: CAYMAN IN THIS ISSUE OF THE THE OF ISSUE THIS IN DISEASES INFECTIOUS EMERGING AAI Looks Back: How Honolulu’s Chinatown FOR STRATEGIES "Went Up in Smoke" A history of the first plague outbreak in Hawai’i, page 30 ANTIVIRAL 28 No. Permit CAYMAN CURRENTS PA Gettysburg, PAID 20852 20852 20852 20852 MD MD MD MD Rockville, Rockville, Rockville, Rockville, 650, 650, 650, 650, Suite Suite Suite Suite Pike, Pike, Pike, Pike, Rockville Rockville Rockville Rockville 1451 1451 1451 1451 Postage U.S. Non-Proft Org. Non-Proft IMMUNOLOGISTS IMMUNOLOGISTS IMMUNOLOGISTS IMMUNOLOGISTS OF OF OF OF ASSOCIATION ASSOCIATION ASSOCIATION ASSOCIATION AMERICAN AMERICAN AMERICAN AMERICAN THE THE THE THE 2020 advanced Course in Immunology Now Virtual! I July 26–31, 2020 IN THIS ISSUE Director: Wayne M. Yokoyama, M.D. Washington University School of Medicine in St. Louis x4 Executive Offce The American Association Don’t miss the premier course in immunology for research scientists! of Immunologists x8 Public Affairs This intensive course is directed toward advanced trainees and scientists who wish to expand or update 1451 Rockville Pike, Suite 650 their understanding of the feld. Leading experts will present recent advances in the biology of the Rockville, MD 20852 20 Members in the News immune system and address its role in health and disease. This is not an introductory course; Tel: 301-634-7178 attendees will need to have a frm understanding of the principles of immunology. Fax: 301-634-7887 24 Outreach Email: [email protected] Faculty www.aai.org 26 Awards 4 Election Results Ulrich H. von Andrian, Harvard Medical School David Masopust, University of Minnesota Center Member Services 28 Education Ragon Institute of MGH, MIT, and Harvard for Immunology Tel: 301-634-7195 Anatomy of the Immune Response T Cell Memory Email: [email protected] 30 History Jonathan C. Kagan, Children’s Hospital Boston Deepta Bhattacharya, University of Arizona The Journal Harvard Medical School B Cell Memory of Immunology 36 Grants and Awards Deadlines Innate Immunity: Pattern Recognition and Jenny P. Ting, University of North Carolina, Chapel Hill Anti-microbial Mechanisms and Molecular and Cellular Mediators ImmunoHorizons 38 Meetings and Events Kate A. Fitzgerald, University of Massachusetts of Infammation Medical School Tel: 301-634-7197 Alex K. Shalek, MIT, Ragon Institute of MGH, MIT, Innate Immunity: Gene Regulation Email: [email protected] and Harvard, Broad Institute of MIT and Harvard www.jimmunol.org Wayne M. Yokoyama, Washington University Single Cell RNA-seq Analysis 20 AAI Members Elected School of Medicine www.immunohorizons.org to NAS Cathryn Nagler, University of Chicago Redness II: Parasites, Th2 Type III: Immune Complex Heat NK Cells—Their Receptors and Function Type I: IgE-Mediated Type II: IgG-Mediated Type IV: Cell-Mediated Mediated Effect of the Microbiome on Immunity Council Edema Pain Response in Health and Disease Alternative I: Intracellular, Th1 III: Extracellular(sm), Th17 Hypersensitivity Opsonization for phagocytosis Pathway(Fastest) Types Reactions Lysis(MAC) Classic Inflammation: Pathway(Slowest) Primary Michael S. Diamond, Washington University School localize and Goals eliminate TGF-β secreted from Gregory F. Sonnenberg, Weill Cornell Medicine C3b: a common Immune System Tumor-induced tumor inhibits CD8 and President Mannose-Lectin Complement C3 Convertase denominator Errors Suppression Th1, stimulates Treg(also Pathway System cleaves into inhibit CD8/Th1) of Medicine Intracellular Cell Surface among pathways C3a: Innate Immunity: Cellular Mechanisms Jenny P. Ting, Ph.D. Toll-Like chemotaxis Immune Response to SARS-CoV-2 NOD-Like Pattern PAMPs/MAMPS/DAMPS Adaptive: Slow, more- Recognition Innate: Fast, less-specific Immune System Receptors BCR: only negative activate specific RIG-1-Like Receptors Stephanie Eisenbarth, Yale School of Medicine VDJ Eric Meffre, Yale University C-Type Lectin Barriers Skin Langerhan's Cells TCR Recombintation Vice President Followed Eyes Positive By Negative Dendritic Cells Mucous Cytotoxic: Cell- Selection: T Selection: Membranes Th1(IL-12) produces Contact(Intracellular Respiratory Tract BALT IFN-γ/ TNF-β Pathogens) Cell binds but not too B Cell Tolerance and Autoimmunity MHC well Gary A. Koretzky, M.D., Ph.D. Th2(IL-4/IL-2) GI Tract MALT produces IL-4/IL-5/IL- CD4+: CD8+: Neutrophil 13 MHC II MHC I Eugene M. Oltz, Ohio State University, Wexner Urogenital Tract Th17(IL-6/TGF-β) Class produces IL-17 Switching and Phagocytes Cells Natural Killer Cell Mark S. Anderson, University of California, 3 Steps Hypermutation Treg: Control T cell School of Medicine activation B Cells(APC): Past President Intermediary Class-switch Macrophage(APC) T Cells Cells Synthesize Ig San Francisco Cells The Generation and Modifcation On the Cover: A member of the National Guard in Honolulu enforces Must present to CD4+ for Jeremy M. Boss, Ph.D. Preserve activation Clonal T Cell Tolerance and Autoimmunity Dendritic Cell(APC): Macrophage(APC): learned threats Monocytes Selection and Migrate Phagocytose for future the cordon sanitaire in Chinatown, preventing residents from leaving Expansion of Lymphocyte Antigen Receptor Genes 28 Usingdefense Concept Maps in Mast Cells: Secrete the neighborhood during an outbreak of bubonic plague. Read this Histamine, Jonathan Kipnis, University of Virginia School Secretary-Treasurer Prostaglandins, etc... Lisa A. Borghesi, University of Pittsburgh School story on page 30. Immunology Education of Medicine Eosinophils of Medicine Edith M. Lord, Ph.D. Neuroimmunology Basophils B Cell Development Robert D. Schreiber, Washington University School Councillors Connect with AAI! Avery August, Cornell University of Medicine Mark M. Davis, Ph.D. T Cell Development Tumor Immunology Akiko Iwasaki, Ph.D. Do you have a story or a story idea for a future issue of the AAI Newsletter? Send us an email! Kai W. Wucherpfennig, Dana-Farber Cancer Stephen Jameson, Ph.D. Interested in the latest news from AAI? Keep in touch through our social media channels. Joanne L. Viney, Pandion Therapeutics Institute, Harvard Medical School Ulrich H. von Andrian, M.D. Follow us on Twitter, Facebook, or LinkedIn, and keep abreast of daily developments in the Immunotherapeutics MHC-restricted Antigen Presentation world of immunology. to T Cells Megan A. Cooper, Washington University School Ex-Offcio Members @ImmunologyAAI of Medicine Carrie L. Lucas, Yale School of Medicine David Masopust, Ph.D. Redefning Human Immunology @J_Immunol (The Journal of Immunology) Signaling from Antigen Receptors Eugene M. Oltz, Ph.D. Galit Alter, Ragon Institute of MGH, MIT, and Harvard Tania Watts, Ph.D. @ImmunoHorizons (ImmunoHorizons) Vaccines M. Michele Hogan, Ph.D., @ImmunologyAAI AAI Executive Director linkedin.com/company/the-american-association-of-immunologists To see a list of AAI staff, visit [email protected] (story ideas and comments about the AAI Newsletter) For complete course details and registration, visit www.aai.org/AdvancedCourse www.aai.org/staff For assistance, contact (301) 634-7178 or [email protected]. © The American Association of Immunologists, Inc. www.aai.org AAI NEWSLETTER 3 Nominating Committee 2020–2021 Program Committee 2020–2023 EXECUTIVE (continued) OFFICE Claudia Kemper, Ph.D., AAI ’04 Shane Crotty, Ph.D., AAI ’04 Senior Investigator, National Heart, Professor Lung, and Blood Institute La Jolla Institute for Immunology National Institutes of Health 2020 AAI Election Results COMMITTEES AAI congratulates the following members on their Awards Committee 2020–2023 election to the AAI Council and committees. All terms Eric Meffre, Ph.D., AAI ’07 commenced July 1, 2020. AAI extends a sincere thanks to Jennifer L. Gommerman, Ph.D., Michael A. Farrar, Ph.D., AAI ’00 all candidates who agreed to stand for election. Over 22 Associate Professor with Tenure, percent of AAI voting members submitted ballots in the AAI ’98 Professor, Department of Laboratory Department of Immunobiology election. We thank them for investing in their profession Professor, Department of Medicine and Pathology Yale School of Medicine and in the mission of AAI through their participation. Immunology University of Minnesota University of Toronto COUNCIL Yina H. Huang, Ph.D., AAI ’04 President 2020–2021 Jenny P. Ting, Ph.D., AAI ’97 Associate Professor of Microbiology Publications Committee 2020–2024 Finance Committee 2020–2023 and Immunology William Kenan Professor of Geisel School of Medicine at Bethany B. Moore, Ph.D., AAI ’98 Steven M. Varga, Ph.D., AAI ’03 Genetics and Microbiology- Dartmouth College Immunology Interim Chair and Professor, Professor, Department of University of North Carolina, Department of Microbiology and Microbiology and Immunology Chapel Hill Immunology; Galen B. Toews M.D. University of Iowa Collegiate Professor of Pulmonary Care and Critical Medicine; Professor, Internal Medicine Vice President 2020–2021 University of Michigan Medical School Gary A. Koretzky, M.D., Ph.D., AAI ’92 Nominating Committee 2020–2021 Professor, Weill Cornell Medicine’s Department of Medicine Maria-Luisa Alegre, M.D., Ph.D., Vice Provost for Academic AAI ’97 – Chair ImmunoCasts Integration, Cornell University e Journal of Immunology on your schedule! Director, Cornell Center for Professor, Department of Medicine
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