12/6/2017 Molecular Classification of Endometriosis and Disease Stage Using High-Dimensional Genomic Data Endocrinology. 2014 Dec; 155(12): 4986–4999. PMCID: PMC4239429 Published online 2014 Sep 22. doi: 10.1210/en.2014-1490 Molecular Classification of Endometriosis and Disease Stage Using High-Dimensional Genomic Data John S. Tamaresis, Juan C. Irwin, Gabriel A. Goldfien, Joseph T. Rabban, Richard O. Burney, Camran Nezhat, Louis V. DePaolo, and Linda C. Giudice Center for Reproductive Sciences (J.S.T., J.C.I., G.A.G., L.C.G.), Department of Obstetrics, Gynecology and Reproductive Sciences, and Department of Pathology (J.T.R.), University of California, San Francisco, California 94143; Department of Obstetrics and Gynecology and Clinical Investigation (R.O.B.), Madigan Healthcare System, Tacoma, Washington 98431; Department of Obstetrics and Gynecology (C.N.), Stanford University, Stanford, California 94024; and Fertility and Infertility Branch (L.V.D.), Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 Corresponding author. Address all correspondence and requests for reprints to: Linda C. Giudice, MD, PhD, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, 505 Parnassus Avenue, Room 1496, San Francisco, CA 94143-0132., E- mail:
[email protected]. Received 2014 Jun 17; Accepted 2014 Sep 15. Copyright © 2014 by the Endocrine Society Abstract Endometriosis (E), an estrogen-dependent, progesterone-resistant, inflammatory disorder, affects 10% of reproductive-age women. It is diagnosed and staged at surgery, resulting in an 11-year latency from symptom onset to diagnosis, underscoring the need for less invasive, less expensive approaches.