First Name Last Name Company Relationship Company Relationship Company Relationship Company Relationship Company Relationship Company Relationship Company Relationship Company Relationship Company Relationship Company Relationship Company Relationship Company Relationship Company Relationship Company Relationship Company Relationship Company Relationship Company Relationship Company Relationship Company Relationship Company Relationship Company Relationship

Viola Andresen Boehringer Ingelheim Speaker Bureau AstraZeneca Pharmaceuticals Speaker Bureau AstraZeneca Pharmaceuticals Consultant Allergan Consultant Falk Speaker Bureau Schwabe Speaker Bureau

Qasim Aziz Grunenthal Advisory Board Ono Pharmaceuticals Other (grants, etc) Protexin Probiotics Other (grants, etc) Almirall Pharmaceuticals Advisory Board

Fernando Azpiroz Almirall Pharmaceuticals Advisory Board Danone Other (grants, etc) Beneo Other (grants, etc) Shire Pharmaceuticals Other (grants, etc) Given Other (grants, etc.) Clasado Other (grants, etc.)

Giovanni Barbara Danone Speaker Bureau Nestle Speaker Bureau Yakult Other (grants, etc) Sofar Other (grants, etc) Almirall Pharmaceuticals Speaker Bureau Shire Pharmaceuticals Other (grants, etc.) Parmalat Other (grants, etc.) Falk Other (grants, etc.) Biogaia Other (grants, etc.)

Marc Benninga Shire Pharmaceuticals Consultant AstraZeneca Pharmaceuticals Consultant Danone Consultant Norgine Consultant Zeria Pharmaceuticals Consultant Sucampo Pharmaceuticals Consultant Friesland-Campina Consultant

Adil Bharucha Medspira Consultant Medspira Other (grants, etc) Allergan-Actavis Pharmaceuticals Consultant Macmillan Med Comm Consultant Forum Consultant National Center for Pelvic Pain Research Consultant Guy Boeckxstaens Menarini Speaker Bureau Reckitt Benckiser Advisory Board Reckitt Benckiser Speaker Bureau

Michael Camilleri Rhythm (fee to Mayo) Consultant Theravance (fee to Mayo) Consultant Teva (fee to Mayo) Consultant GlaxoSmithKline (fee to Mayo) Consultant Shire Pharmaceuticals (fee to Mayo) Consultant AstraZeneca Pharmaceuticals (fee to Camilleri) Consultant BioKier (fee to Camilleri) Consultant Takeda Pharmaceuticals U.S.A. Pharmaceuticals(fee to Mayo) Advisory Board Albireo (fee to Mayo) Consultant Novartis (fee to Mayo) Consultant Ironwood Pharmaceuticals (fee to Mayo) Consultant Elobix AB (fee to Mayo) Consultant Entera Health (fee to Mayo) Consultant Salix/Valeant (fee to Mayo) Consultant ShiOno Pharmaceuticalsgi (fee to Camilleri) Consultant Salix/Valeant Other (grants, etc.) Tsumura Other (grants, etc.) Rhythm Other (grants, etc.) Vibrant Other (grants, etc.) Entera Health Other (grants, etc.) AstraZeneca Pharmaceuticals Other (grants, etc.) Ross Carter None William Cayley None

Francis Chan Antibe Therapeutics Consultant Eisai Co. Consultant AstraZeneca Pharmaceuticals Consultant Pfizer Consultant

Lin Chang Ironwood Pharmaceuticals Advisory Board Forest Laboratories/Actavis Pharmaceuticals Advisory Board QOL Medical Advisory Board Salix/Valeant Advisory Board Takeda Pharmaceuticals U.S.A. Pharmaceuticals Advisory Board Commonwealth Advisory Board AstraZeneca Pharmaceuticals Advisory Board

William Chey Actavis Pharmaceuticals Consultant Ardelyx Consultant AstraZeneca Pharmaceuticals Consultant Forest Laboratories Consultant Ironwood Pharmaceuticals Consultant Prometheus Consultant Nestle Consultant Salix/Valeant Consultant Sucampo Pharmaceuticals Consultant Takeda Pharmaceuticals U.S.A. Consultant Valeant Consultant Vibrant Consultant Ironwood Pharmaceuticals Other (grants, etc.) Nestle Other (grants, etc.) Prometheus Other (grants, etc.) Perrigo Other (grants, etc.) Vibrant Other (grants, etc.)

Giuseppe Chiarioni Shire Pharmaceuticals Speaker Bureau Takeda Pharmaceuticals U.S.A. Advisory Board Myung-Gyu Choi None

Enrico Corazziari Almirall Pharmaceuticals Advisory Board Synergy Pharmaceuticals Consultant ABOCA Consultant SOFAR Other (grants, etc) VALEAS Other (grants, etc.)

Peter Cotton Olympus USA Consultant Apollo Endosurgery Advisory Board SE Healthcare Quality Consulting Advisory Board Cook Medical Other (grants, etc) Michael Crowell Medtronic-Covidien Consultant Salix/Valeant Consultant Fabrizio De Ponti None Niek De Wit None

Carlo Di Lorenzo Sucampo Pharmaceuticals Consultant Merck Pharmaceuticals Consultant QOL Medical Other (grants, etc)

Doug Drossman Takeda Pharmaceuticals U.S.A. Advisory Board Ironwood Pharmaceuticals Consultant AstraZeneca Pharmaceuticals Consultant Allergan Consultant Synergy Consultant

Dan Dumitrascu Alfa Wasserman Speaker Bureau Takeda Pharmaceuticals U.S.A. Speaker Bureau Abbott Laboratories Speaker Bureau Zentiva Speaker Bureau Pfizer Speaker Bureau Danone Speaker Bureau SICOMED Speaker Bureau Merck Pharmaceuticals Speaker Bureau Reckitt Benckiser Speaker Bureau Mylan Speaker Bureau Sigrid Elsenbruch None Grace Elta Olympus USA Consultant

Anton Emmanuel Almirall Pharmaceuticals Advisory Board Coloplast Advisory Board Shire Pharmaceuticals Speaker Bureau Shire Pharmaceuticals Other (grants, etc) Wellspect Advisory Board MundiPharma Speaker Bureau

Xiucai Fang Xian-Janssen Pharmaceuticals Consultant Beaufoar-Ipsen Speaker Bureau Xian-Janssen Pharmaceuticals Speaker Bureau Sumitomo (Suzhou) Speaker Bureau

Ronnie Fass Takeda Pharmaceuticals U.S.A. Consultant Takeda Pharmaceuticals U.S.A. Speaker Bureau Mederi Consultant Mederi Speaker Bureau Vecta Consultant Ironwood Pharmaceuticals Consultant Ironwood Pharmaceuticals Other (grants, etc.) Evoke Other (grants, etc.) Pfizer Consultant Torax Consultant Medtronic Consultant Christophe Faure None Christine Feinle-Bisset None Richelle Felt-Bersma None

Carlos Francisconi Danone Advisory Board Abbvie Speaker Bureau Janssen Pharmaceuticals Other (grants, etc) Ferring Pharmaceuticals Speaker Bureau Takeda Pharmaceuticals U.S.A. Pharmaceuticals Consultant

Shin Fukudo Astellas Pharma U.S. Advisory Board Astellas Pharma U.S. Speaker Bureau Astellas Pharma U.S. Other (grants, etc) Dainippon-Sumitomo Advisory Board Dainippon-Sumitomo Other (grants, etc.) Abbott Laboratories Japan Speaker Bureau Abbott Laboratories Japan Other (grants, etc.) Sucampo Pharmaceuticals Advisory Board Ono Pharmaceuticals Advisory Board Kissei Advisory Board Sanwa Advisory Board Zeria Pharmaceuticals Advisory Board GlaxoSmithKline Other (grants, etc.) Mochida Other (grants, etc.) ShiOno Pharmaceuticalsgi Other (grants, etc.) Tsumura Other (grants, etc.) Smoking Research Foundation Other (grants, etc.) Kao Other (grants, etc.) Mary Joan Gerson None Uday Ghoshal None

Beverley Greenwood-Van Meerveld GlaxoSmithKline Other (grants etc) Ironwood Pharmaceuticals Other (grants, etc) Whitesands Other (grants, etc)

David Grundy Takeda Pharmaceuticals U.S.A. Pharmaceuticals Advisory Board UCB Pharma Advisory Board Elsepth Guthrie None

Kok Ann Gwee Danone Advisory Board Janssen Pharmaceuticals Other (grants, etc) Janssen Pharmaceuticals Consultant Abbott Laboratories Advisory Board Abbott Laboratories Speaker Bureau Eisai Other (grants, etc.) Takeda Pharmaceuticals U.S.A. Other (grants, etc.) Menarini AsiaPac Advisory Board Menarini AsiaPac Consultant Menarini AsiaPac Speaker Bureau Menarini AsiaPac Other (grants, etc.) Albena Halpert Allergan Advisory Board

William Hasler Ironwood Pharmaceuticals Consultant Medtronic Other (grants, etc) Rhythm Pharma Other (grants, etc) Margaret Heitkemper Salix/Valeant Other (grants etc)

Lesley Houghton Takeda Pharmaceuticals U.S.A. Other (grants etc) Pfizer Consultant GlaxoSmithKline Consultant Jeff Hyams None Paul Hyman None Jan Irvine None Jin-Yong Kang None

Meiyun Ke Janssen Pharmaceuticals Speaker Bureau Laurie Keefer None Charles Knowles Medtronic Advisory Board Medtronic Speaker Bureau Medtronic Other (grants, etc) Jeff Lackner None

Brian Lacy Ironwood Pharmaceuticals Advisory Board Takeda Pharmaceuticals U.S.A. Advisory Board Coviden Consultant

Tony Lembo Ironwood Pharmaceuticals Consultant Ironwood Pharmaceuticals Advisory Board Valeant Consultant Valeant Advisory Board Allergan Consultant Allergan Advisory Board Prometheus Consultant Prometheus Other (grants, etc.) Alkermes Consultant Rona Levy None

Greger Lindberg Almirall Pharmaceuticals Consultant Meda Speaker Bureau Shire Pharmaceuticals Consultant Ferring Pharmaceuticals Consultant AstraZeneca Pharmaceuticals Consultant

Juan Malagelada Almirall Pharmaceuticals Consultant Shire Pharmaceuticals Advisory Board Given Other (grants, etc) Allison Malcolm None

Gary Mawe Ironwood Pharmaceuticals Research study Dignify Advisory Board Jim McRoberts None

Fermin Mearin Almirall Pharmaceuticals Advisory Board Menarini Advisory Board Novartis Advisory Board Shire Pharmaceuticals Advisory Board Shire Pharmaceuticals Speaker Bureau Abbott Laboratories Speaker Bureau Alfa Wassermann Speaker Bureau Janssen Pharmaceuticals Speaker Bureau Novartis Speaker Bureau Almirall Pharmaceuticals Speaker Bureau

Hiroto Miwa AstraZeneca Pharmaceuticals Advisory Board AstraZeneca Pharmaceuticals Speaker Bureau Daiichi-Sankyo Advisory Board Daiichi-Sankyo Speaker Bureau Takeda Pharmaceuticals U.S.A. Pharmaceuticals Advisory Board Takeda Pharmaceuticals U.S.A. Speaker Bureau Astellas Pharma U.S. Advisory Board Astellas Pharma U.S. Speaker Bureau Zeria Pharmaceuticals Speaker Bureau Bruce Naliboff None Samuel Nurko None

Kevin Olden Ironwood Pharmaceuticals Consultant Allergan Consultant

John Pandolfino Medtronic Speaker Bureau Medtronic Consultant Sandhill Consultant Sandhill Speaker Bureau AstraZeneca Pharmaceuticals Speaker Bureau Takeda Pharmaceuticals U.S.A. Speaker Bureau Ironwood Pharmaceuticals Consultant Crospon Stock options Henry Parkman Theravance Other (grants etc) Evoke Other (grants, etc) Jay Pasricha Neurogastrx Other (grants etc) Orphomed Other (grants, etc) ETX Pharma Other (grants, etc) FAST Other (grants, etc)

Gyawali Prakash Given Other (grants etc) Forest Laboratories Speaker Bureau Ironwood Pharmaceuticals Speaker Bureau Quintiles Consultant Abbott Laboratories Consultant Valeant Consultant

Eamonn Quigley Ironwood Pharmaceuticals Advisory Board Salix/Valeant Advisory Board Almirall Pharmaceuticals Advisory Board Rhythm Consultant Shire Pharmaceuticals Consultant Procter & Gamble Speaker Bureau Vibrant Consultant Alimentary Health Consultant

Satish Rao Forest Laboratories Advisory Board Hollister Advisory Board Ironwood Pharmaceuticals Advisory Board Sucampo Pharmaceuticals Advisory Board Sunsweet Corp Other (grants, etc.) Synergy Pharmaceuticals Other (grants, etc.) Salix/Valeant Other (grants, etc.) Ventrus Other (grants, etc.) Intone MV Advisory Board Intone MV Other (grants, etc.) Javier Santos None Miguel Saps QOL Medical Consultant Quintiles Consultant Forest Laboratories Consultant Neil Schechter None

Max Schmulson Alfa Wasserman Other (grants etc) Alfa Wassermann Speaker Bureau Takeda Pharmaceuticals U.S.A. PharmaceuticalsMexico Speaker Bureau Takeda Pharmaceuticals U.S.A. PharmaceuticalsMexico Other (grants, etc) Mayoly-Spindler Speaker Bureau Commonwealth Labs Consultant Commonwealth Diagnostics Consultant Robert Schulman Nutrinia Consultant Mead-Johnson Other (grants, etc) Gerson-Lehrman Consultant

Terez Shea-DOno Pharmaceuticalshue NovOno Pharmaceuticalsrtis Other (grants etc) Daniel Sifrim Reckitt Benckiser Advisory Board Sandhill Scientific Other (grants, etc) Ono Pharmaceuticals Other (grants, etc)

Magnus Simren Danone Advisory Board Danone Other (grants, etc) AstraZeneca Pharmaceuticals Advisory Board Almirall Pharmaceuticals Advisory Board Nestle Advisory Board Shire Pharmaceuticals Advisory Board Glycom Advisory Board Abbvie Speaker Bureau Tillotts Speaker Bureau Takeda Pharmaceuticals U.S.A. Speaker Bureau Shire Pharmaceuticals Speaker Bureau Menarini Speaker Bureau Oy Verman Other (grants, etc.) Ami Sperber Vibrant Consultant

Brennan Spiegel Ironwood Pharmaceuticals Other (grants etc) Shire Pharmaceuticals Other (grants, etc) Takeda Pharmaceuticals U.S.A. Other (grants, etc) Takeda Pharmaceuticals U.S.A. Advisory Board Amgen Other (grants, etc.) Nestle Other (grants, etc.) Theravance Other (grants, etc.) Commonwealth Advisory Board Synergy Pharmaceuticals Advisory Board Ironwood Pharmaceuticals Advisor Allergan Advisor

Robin Spiller Lesaffre Other (grants etc) Ironwood Pharmaceuticals Other (grants, etc) Almirall Pharmaceuticals Advisory Board Yuhan Advisory Board Ibsen Advisory Board Danone Advisory Board Menarini Speaker Bureau Ian St. James-Roberts None

Annamaria Staiano Aboca Consultant Angelini Speaker Bureau Danone Speaker Bureau D.M.G. Italy Consultant Milte Speaker Bureau Nestle Speaker Bureau Sucampo Pharmaceuticals Consultant Valeas Speaker Bureau

Vincenzo Stanghellini Alfa Wasserman Consultant Alfa Wassermann Speaker Bureau Almirall Pharmaceuticals Speaker Bureau Angelini Consultant Angelini Speaker Bureau Janssen Pharmaceuticals Speaker Bureau Shire Pharmaceuticals Speaker Bureau Shire Pharmaceuticals Other (grants, etc.) Valeas Speaker Bureau

Hidekazu Suzuki Astellas Pharma U.S. Other (grants etc) Zeria Pharmaceuticals Other (grants, etc) Takeda Pharmaceuticals U.S.A. Other (grants, etc) AstraZeneca Pharmaceuticals KK Other (grants, etc) Otsuka Other (grants, etc.) Daiichi Sankyo Other (grants, etc.)

Jan Tack Abide Therapeutics Other (grants etc) Alfa Wassermann Advisory Board Almirall Pharmaceuticals Speaker Bureau AstraZeneca Pharmaceuticals Speaker Bureau Danone Advisory Board GlaxoSmithKline Advisory Board Ironwood Pharmaceuticals Advisory Board Janssen Pharmaceuticals Advisory Board Menarini Advisory Board Mylan Advisory Board

Nick Talley Abbott Laboratories Other (grants etc) Janssen Pharmaceuticals Other (grants, etc) Prometheus Other (grants, etc) Adelphi Consultant Yuhan Consultant IMHealth Sciences Consultant Kirsten Tillisch Tsumura Other (grants etc) Brenda Toner None Lukas Van Oudenhove None

Miranda van Tilburg Takeda Pharmaceuticals U.S.A. Other (grants etc)

Steve Vanner Ferring Pharmaceuticals/Canada Other (grants etc) Ferring Pharmaceuticals/Canada Speaker Bureau Ferring Pharmaceuticals/US Other (grants, etc) Allergan Speaker Bureau Elena Verdu Nestle Other (grants etc) Nathalie Vergnolle None

Arnold Wald Takeda Pharmaceuticals U.S.A. Consultant Sucampo Pharmaceuticals Consultant Theravance Consultant Actavis Pharmaceuticals Consultant

William Whitehead Biomerica USA Consultant Ono Pharmaceuticals Consultant Salix/Valeant/Valeant Consultant Ferring Pharmaceuticals Consultant Takeda Pharmaceuticals U.S.A. Pharmaceuticals Other (grants, etc.) Ironwood Pharmaceuticals Other (grants, etc.) Salix/Valeant/Valeant Other (grants, etc.) Ferring Pharmaceuticals Other (grants, etc.)

Peter Whorwell Danone Advisory Board Sucampo Pharmaceuticals Advisory Board Almirall Pharmaceuticals Advisory Board Ironwood Pharmaceuticals Other (grants, etc) Chr. Hansen Advisory Board Salix/Valeant Other (grants, etc.) Boehringer-Ingelheim Advisory Board Allergan Advisory Board

Jackie Wood Sucampo Pharmaceuticals Other (grants etc) Takeda Pharmaceuticals U.S.A. Speaker Bureau

Yunsheng Yang Janssen Pharmaceuticals NV Other (grants etc)

Frank Zerbib Given Advisory Board Reckitt Benckiser Consultant Mederi Consultant Almirall Pharmaceuticals Advisory Board Shire Pharmaceuticals Advisory Board Addex Pharma Consultant Abbvie Speaker Bureau Cephalon Speaker Bureau Latitude Medical Speaker Bureau Janssen Pharmaceuticals Clag Speaker Bureau Allergan Consultant Vifor Pharma Speaker Bureau Takeda Pharmaceuticals U.S.A. Speaker Bureau Erwin Zoetendal None