Biology Study Packet the Brain
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The Baseline Structure of the Enteric Nervous System and Its Role in Parkinson’S Disease
life Review The Baseline Structure of the Enteric Nervous System and Its Role in Parkinson’s Disease Gianfranco Natale 1,2,* , Larisa Ryskalin 1 , Gabriele Morucci 1 , Gloria Lazzeri 1, Alessandro Frati 3,4 and Francesco Fornai 1,4 1 Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy; [email protected] (L.R.); [email protected] (G.M.); [email protected] (G.L.); [email protected] (F.F.) 2 Museum of Human Anatomy “Filippo Civinini”, University of Pisa, 56126 Pisa, Italy 3 Neurosurgery Division, Human Neurosciences Department, Sapienza University of Rome, 00135 Rome, Italy; [email protected] 4 Istituto di Ricovero e Cura a Carattere Scientifico (I.R.C.C.S.) Neuromed, 86077 Pozzilli, Italy * Correspondence: [email protected] Abstract: The gastrointestinal (GI) tract is provided with a peculiar nervous network, known as the enteric nervous system (ENS), which is dedicated to the fine control of digestive functions. This forms a complex network, which includes several types of neurons, as well as glial cells. Despite extensive studies, a comprehensive classification of these neurons is still lacking. The complexity of ENS is magnified by a multiple control of the central nervous system, and bidirectional communication between various central nervous areas and the gut occurs. This lends substance to the complexity of the microbiota–gut–brain axis, which represents the network governing homeostasis through nervous, endocrine, immune, and metabolic pathways. The present manuscript is dedicated to Citation: Natale, G.; Ryskalin, L.; identifying various neuronal cytotypes belonging to ENS in baseline conditions. -
Distance Learning Program Anatomy of the Human Brain/Sheep Brain Dissection
Distance Learning Program Anatomy of the Human Brain/Sheep Brain Dissection This guide is for middle and high school students participating in AIMS Anatomy of the Human Brain and Sheep Brain Dissections. Programs will be presented by an AIMS Anatomy Specialist. In this activity students will become more familiar with the anatomical structures of the human brain by observing, studying, and examining human specimens. The primary focus is on the anatomy, function, and pathology. Those students participating in Sheep Brain Dissections will have the opportunity to dissect and compare anatomical structures. At the end of this document, you will find anatomical diagrams, vocabulary review, and pre/post tests for your students. The following topics will be covered: 1. The neurons and supporting cells of the nervous system 2. Organization of the nervous system (the central and peripheral nervous systems) 4. Protective coverings of the brain 5. Brain Anatomy, including cerebral hemispheres, cerebellum and brain stem 6. Spinal Cord Anatomy 7. Cranial and spinal nerves Objectives: The student will be able to: 1. Define the selected terms associated with the human brain and spinal cord; 2. Identify the protective structures of the brain; 3. Identify the four lobes of the brain; 4. Explain the correlation between brain surface area, structure and brain function. 5. Discuss common neurological disorders and treatments. 6. Describe the effects of drug and alcohol on the brain. 7. Correctly label a diagram of the human brain National Science Education -
Human Anatomy (Biology 2) Lecture Notes Updated July 2017 Instructor
Human Anatomy (Biology 2) Lecture Notes Updated July 2017 Instructor: Rebecca Bailey 1 Chapter 1 The Human Body: An Orientation • Terms - Anatomy: the study of body structure and relationships among structures - Physiology: the study of body function • Levels of Organization - Chemical level 1. atoms and molecules - Cells 1. the basic unit of all living things - Tissues 1. cells join together to perform a particular function - Organs 1. tissues join together to perform a particular function - Organ system 1. organs join together to perform a particular function - Organismal 1. the whole body • Organ Systems • Anatomical Position • Regional Names - Axial region 1. head 2. neck 3. trunk a. thorax b. abdomen c. pelvis d. perineum - Appendicular region 1. limbs • Directional Terms - Superior (above) vs. Inferior (below) - Anterior (toward the front) vs. Posterior (toward the back)(Dorsal vs. Ventral) - Medial (toward the midline) vs. Lateral (away from the midline) - Intermediate (between a more medial and a more lateral structure) - Proximal (closer to the point of origin) vs. Distal (farther from the point of origin) - Superficial (toward the surface) vs. Deep (away from the surface) • Planes and Sections divide the body or organ - Frontal or coronal 1. divides into anterior/posterior 2 - Sagittal 1. divides into right and left halves 2. includes midsagittal and parasagittal - Transverse or cross-sectional 1. divides into superior/inferior • Body Cavities - Dorsal 1. cranial cavity 2. vertebral cavity - Ventral 1. lined with serous membrane 2. viscera (organs) covered by serous membrane 3. thoracic cavity a. two pleural cavities contain the lungs b. pericardial cavity contains heart c. the cavities are defined by serous membrane d. -
The Enteric Nervous System: a Second Brain
The Enteric Nervous System: A Second Brain MICHAEL D. GERSHON Columbia University Once dismissed as a simple collection of relay ganglia, the enteric nervous system is now recognized as a complex, integrative brain in its own right. Although we still are unable to relate complex behaviors such as gut motility and secretion to the activity of individual neurons, work in that area is proceeding briskly--and will lead to rapid advances in the management of functional bowel disease. Dr. Gershon is Professor and Chair, Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York. In addition to numerous scientific publications, he is the author of The Second Brain (Harper Collins, New York, 1998). Structurally and neurochemically, the enteric nervous system (ENS) is a brain unto itself. Within those yards of tubing lies a complex web of microcircuitry driven by more neurotransmitters and neuromodulators than can be found anywhere else in the peripheral nervous system. These allow the ENS to perform many of its tasks in the absence of central nervous system (CNS) control--a unique endowment that has permitted enteric neurobiologists to investigate nerve cell ontogeny and chemical mediation of reflex behavior in a laboratory setting. Recognition of the importance of this work as a basis for developing effective therapies for functional bowel disease, coupled with the recent, unexpected discovery of major enteric defects following the knockout of murine genes not previously known to affect the gut, has produced a groundswell of interest that has attracted some of the best investigators to the field. Add to this that the ENS provides the closest thing we have to a window on the brain, and one begins to understand why the bowel--the second brain--is finally receiving the attention it deserves. -
The Remarkable, Yet Not Extraordinary, Human Brain As a Scaled-Up Primate Brain and Its Associated Cost
The remarkable, yet not extraordinary, human brain as a scaled-up primate brain and its associated cost Suzana Herculano-Houzel1 Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, 21941-902, Rio de Janeiro, Brazil; and Instituto Nacional de Neurociência Translacional, Instituto Nacional de Ciência e Tecnologia/Ministério de Ciência e Tecnologia, 04023-900, Sao Paulo, Brazil Edited by Francisco J. Ayala, University of California, Irvine, CA, and approved April 12, 2012 (received for review February 29, 2012) Neuroscientists have become used to a number of “facts” about the The incongruity between our extraordinary cognitive abilities human brain: It has 100 billion neurons and 10- to 50-fold more glial and our not-that-extraordinary brain size has been the major cells; it is the largest-than-expected for its body among primates driving factor behind the idea that the human brain is an outlier, and mammals in general, and therefore the most cognitively able; an exception to the rules that have applied to the evolution of all it consumes an outstanding 20% of the total body energy budget other animals and brains. A largely accepted alternative expla- despite representing only 2% of body mass because of an increased nation for our cognitive superiority over other mammals has been metabolic need of its neurons; and it is endowed with an overde- our extraordinary brain size compared with our body size, that is, veloped cerebral cortex, the largest compared with brain size. our large encephalization quotient (8). Compared -
Nomina Histologica Veterinaria, First Edition
NOMINA HISTOLOGICA VETERINARIA Submitted by the International Committee on Veterinary Histological Nomenclature (ICVHN) to the World Association of Veterinary Anatomists Published on the website of the World Association of Veterinary Anatomists www.wava-amav.org 2017 CONTENTS Introduction i Principles of term construction in N.H.V. iii Cytologia – Cytology 1 Textus epithelialis – Epithelial tissue 10 Textus connectivus – Connective tissue 13 Sanguis et Lympha – Blood and Lymph 17 Textus muscularis – Muscle tissue 19 Textus nervosus – Nerve tissue 20 Splanchnologia – Viscera 23 Systema digestorium – Digestive system 24 Systema respiratorium – Respiratory system 32 Systema urinarium – Urinary system 35 Organa genitalia masculina – Male genital system 38 Organa genitalia feminina – Female genital system 42 Systema endocrinum – Endocrine system 45 Systema cardiovasculare et lymphaticum [Angiologia] – Cardiovascular and lymphatic system 47 Systema nervosum – Nervous system 52 Receptores sensorii et Organa sensuum – Sensory receptors and Sense organs 58 Integumentum – Integument 64 INTRODUCTION The preparations leading to the publication of the present first edition of the Nomina Histologica Veterinaria has a long history spanning more than 50 years. Under the auspices of the World Association of Veterinary Anatomists (W.A.V.A.), the International Committee on Veterinary Anatomical Nomenclature (I.C.V.A.N.) appointed in Giessen, 1965, a Subcommittee on Histology and Embryology which started a working relation with the Subcommittee on Histology of the former International Anatomical Nomenclature Committee. In Mexico City, 1971, this Subcommittee presented a document entitled Nomina Histologica Veterinaria: A Working Draft as a basis for the continued work of the newly-appointed Subcommittee on Histological Nomenclature. This resulted in the editing of the Nomina Histologica Veterinaria: A Working Draft II (Toulouse, 1974), followed by preparations for publication of a Nomina Histologica Veterinaria. -
Anatomy of the Pig
Hands on Workshop: Lecture for Animal Workshop Anatomy of the pig Jong Man Kim1, Hae Won Lee2 Sungkyunkwan University1, Seoul National University2, Korea Introduction The digestive system of swine has anatomic differences from humans. However, the physiology of digestion remains similar to humans. In spite of the anatomic differences, the pig has been used extensively as a gastro- intestinal model. Most of the classical models involving the digestive system have been related to nutritional stud- ies to study digestion of the pig and for studying human digestive phenomenon. More recently endoscopic and laparoscopic surgical models have been developed and used extensively in the swine. The size and function of structures such as the biliary system and pancreatic duct make them amenable for studying human sized equip- ment and biomaterial implants. Surgical modifications have made the intestinal tract amenable to the study of surgical and chronic fistulation procedures. Laparoscopic surgery has replaced many open operations. The procedures described are commonly performed laparoscopically by many general surgeons but require practice. The porcine model is ideal to train surgeons in laparoscopic procedures since porcine anatomy is generally similar to humans with some minor differences. Liver 1. Morphological feature In the human, the liver morphologically consists of 4 lobes; the left, right, quadrate, and caudate lobes al- though the functional anatomy is more important than the morphological one, which is rarely used in clinical field. Unlikely to the human, the porcine liver consists of 5 lobes; the left lateral and medial, right lateral and medial, and caudate lobes. In the ventral view, 4 lobes are seen; the left lateral, left medial, right medial, and right lateral lobes in sequence from left to right. -
Neuroscience: Systems, Behavior & Plasticity 1
Neuroscience: Systems, Behavior & Plasticity 1 Neuroscience: Systems, Behavior & Plasticity Debra Bangasser, Director 873 Weiss Hall 215-204-1015 [email protected] Rebecca Brotschul, Program Coordinator 618 Weiss Hall 215-204-3441 [email protected] https://liberalarts.temple.edu/departments-and-programs/neuroscience/ A major in Neuroscience enables students to pursue a curriculum in several departments, colleges, and schools at Temple University in one of the most dynamic areas of science. Neuroscience is an interdisciplinary field addressing neural and brain function at multiple levels. It encompasses a broad domain that ranges from molecular genetics and neural development, to brain processes involved in cognition and emotion, to mechanisms and consequences of neurodegenerative disease. The field of neuroscience also includes mathematical and physical principles involved in modeling neural systems and in brain imaging. The undergraduate, interdisciplinary Neuroscience Major will culminate in a Bachelor of Science degree. Many high-level career options within and outside of the field of neuroscience are open to students with this major. This is a popular major with students aiming for professional careers in the health sciences such as in medicine, dentistry, pharmacy, physical and occupational therapy, and veterinary science. Students interested in graduate school in biology, chemistry, communications science, neuroscience, or psychology are also likely to find the Neuroscience Major attractive. Neuroscience Accelerated +1 Bachelor of Science / Master of Science Program The accelerated +1 Bachelor of Science / Master of Science in Neuroscience: Systems, Behavior and Plasticity program offers outstanding Temple University Neuroscience majors the opportunity to earn both the BS and MS in Neuroscience in just 5 years. -
Neuroscience: the Science of the Brain
NEUROSCIENCE SCIENCE OF THE BRAIN AN INTRODUCTION FOR YOUNG STUDENTS British Neuroscience Association European Dana Alliance for the Brain Neuroscience: the Science of the Brain 1 The Nervous System P2 2 Neurons and the Action Potential P4 3 Chemical Messengers P7 4 Drugs and the Brain P9 5 Touch and Pain P11 6 Vision P14 Inside our heads, weighing about 1.5 kg, is an astonishing living organ consisting of 7 Movement P19 billions of tiny cells. It enables us to sense the world around us, to think and to talk. The human brain is the most complex organ of the body, and arguably the most 8 The Developing P22 complex thing on earth. This booklet is an introduction for young students. Nervous System In this booklet, we describe what we know about how the brain works and how much 9 Dyslexia P25 there still is to learn. Its study involves scientists and medical doctors from many disciplines, ranging from molecular biology through to experimental psychology, as well as the disciplines of anatomy, physiology and pharmacology. Their shared 10 Plasticity P27 interest has led to a new discipline called neuroscience - the science of the brain. 11 Learning and Memory P30 The brain described in our booklet can do a lot but not everything. It has nerve cells - its building blocks - and these are connected together in networks. These 12 Stress P35 networks are in a constant state of electrical and chemical activity. The brain we describe can see and feel. It can sense pain and its chemical tricks help control the uncomfortable effects of pain. -
10 Things to Know About Neuromodulation. Minimally Invasive Procedures to Reduce Or Alleviate Pain
NORTH AMERICAN NEUROMODULATION SOCIETY 4700 W. Lake Avenue Glenview, IL 60025 www.neuromodulation.org Rubenstein Public Relations Contact: Eve McGrath Tel: 212-843-8490 Email: [email protected] FOR IMMEDIATE RELEASE 10 Things to Know About Neuromodulation Minimally Invasive Procedures to Reduce or Alleviate Pain NEW YORK – February 24, 2010 – Robert Foreman, Ph.D., president of the North American Neuromodulation Society (NANS), stated, “Neuromodulation is among the most rapidly growing fields in medicine today. It can help to relieve chronic back pain, pain from cancer and other nerve injuries, pain from Complex Regional Pain Syndrome (CRPS) and Reflex Sympathetic Dystrophy (RSD) greatly improving the quality of life for patients.” Neuromodulation encompasses the application of targeted electrical, chemical and biological technologies to the nervous system in order to improve function and quality of life. The appropriate therapy (low level electrical pulses or micro-doses of medicine) are targeted to nerves along the spinal cord to block pain signals to the brain According to Joshua Prager, MD, MS, former president of NANS, “Neuromodulation can give people their lives back. Patients have gone from wheelchairs back to the tennis court, back to the sidelines of their children’s soccer games, back to their jobs. There are few treatments that can improve the activity level and the psychological outlook of a patient in pain like neuromodulation techniques.” NANS has compiled ten things everyone should know about neuromodulation: 1. Neuromodulation alleviates or lessens pain without putting patients into a “drug fog.” By relieving pain with neuro-stimulation or a drug-delivery system, that provides micro- doses of medicine, the patient can avoid some side effects, including excessive sedation or clouding of thoughts. -
The Resilient Brain
research into practice The Resilient Brain Larry K. Brendtro and James E. Longhurst Brain research opens new frontiers in working with children and youth experiencing conflict in school and community. Blending this knowledge with resilience science offers a roadmap for reclaiming those identified as “at risk.” This article applies findings from resilience research and recent brain research to identify strategies for reaching challenging youngsters. All young persons have strengths and with positive support can change the course of their lives. They have resilient brains that can be “rewired” by positive learning experiences. Risk and Resilience rather than breaks. To extend the analogy, a resilient youth not only springs back from adversity but can Resilience is the ability to thrive in spite of risk or become stronger in the process, like tempered steel. adversity. Youth at risk and children at risk first came They can develop an inner strength that has been into wide use in the 1980s. Originally this referred to called “survivor’s pride” (Wolin & Wolin, 2004). dangerous environments, such as disrupted families This feeling of accomplishment that comes from and dysfunctional schools. But terms like at-risk solving challenging life problems is at the core of youth and high risk behavior shifted the focus from resilience. But those who take a “deficit” perspective how to build supportive environments to finding overlook the potential strengths of youth to sur- supposed defects in the child. Those who labeled mount difficult experiences and environments. youth as “violent” or “predators” created fear of dangerous children while letting adults off the hook Initially some researchers thought resilience was a (Males, 1996). -
Recent Advances in the Detection of Neurotransmitters
chemosensors Review Recent Advances in the Detection of Neurotransmitters Bo Si 1 and Edward Song 1,2,* ID 1 Department of Electrical and Computer Engineering, University of New Hampshire, Durham, NH 03824, USA; [email protected] 2 Center for Advanced Materials and Manufacturing Innovation, University of New Hampshire, Durham, NH 03824, USA * Correspondence: [email protected]; Tel.: +1-603-862-5498 Received: 3 December 2017; Accepted: 2 January 2018; Published: 4 January 2018 Abstract: Neurotransmitters are chemicals that act as messengers in the synaptic transmission process. They are essential for human health and any imbalance in their activities can cause serious mental disorders such as Parkinson’s disease, schizophrenia, and Alzheimer’s disease. Hence, monitoring the concentrations of various neurotransmitters is of great importance in studying and diagnosing such mental illnesses. Recently, many researchers have explored the use of unique materials for developing biosensors for both in vivo and ex vivo neurotransmitter detection. A combination of nanomaterials, polymers, and biomolecules were incorporated to implement such sensor devices. For in vivo detection, electrochemical sensing has been commonly applied, with fast-scan cyclic voltammetry being the most promising technique to date, due to the advantages such as easy miniaturization, simple device architecture, and high sensitivity. However, the main challenges for in vivo electrochemical neurotransmitter sensors are limited target selectivity, large background signal and noise, and device fouling and degradation over time. Therefore, achieving simultaneous detection of multiple neurotransmitters in real time with long-term stability remains the focus of research. The purpose of this review paper is to summarize the recently developed sensing techniques with the focus on neurotransmitters as the target analyte, and to discuss the outlook of simultaneous detection of multiple neurotransmitter species.