The MS4A Gene Cluster Is a Key Modulator of Soluble TREM2 and Alzheimer
The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer disease risk Yuetiva Deming1*, Fabia Filipello2*, Francesca Cignarella2*, Claudia Cantoni2, Simon Hsu1, Robert Mikesell2, Zeran Li1, Jorge L Del-Aguila1, Umber Dube1, Fabiana Geraldo Farias1, Joseph Bradley1, John Budde1, Laura Ibanez1, Maria Victoria Fernandez1, Alzheimer’s Disease Neuroimaging Initiative (ADNI)†, Dominantly Inherited Alzheimer Network (DIAN), Kaj Blennow3,4,5,6, Henrik Zetterberg3,4,5,6, Amanda Heslegrave5,6, Per M Johansson5,6,7, Johan Svensson8, Bengt Nellgård8, Alberto Lleo9, Daniel Alcolea9, Jordi Clarimon9, Lorena Rami10, José Luis Molinuevo11,12, Marc Suárez-Calvet12, 13,14, Estrella Morenas-Rodríguez13,15, Gernot Kleinberger13,15, Michael Ewers16, Oscar Harari1, Christian Haass13,14,15, Thomas J Brett17, Bruno A. Benitez1#, Celeste M. Karch1,18,#, Laura Piccio2,18,#, Carlos Cruchaga1,18,*,# Affiliations: 1Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid Ave. B8134, St. Louis, MO 63110, USA. 2Department of Neurology, Washington University School of Medicine, St Louis, MO, USA 3Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden. 4Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden. 5Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK. 6UK Dementia Research Institute at UCL, London, UK. 7Department of Anesthesiology and Intensive Care Medicine, Sahlgrenska University. Hospital, Mölndal, Sweden and Institute of Clinical Sciences, the Sahlgrenska Academy at the University of Gothenburg, Sweden 8Department of Internal Medicine, Institute of Medicine, the Sahlgrenska Academy at the University of Gothenburg, Göteborg, Sweden. 9Neurology Dept.
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