Annual Report 2018

YEARS Annual Report 2018

Greeting 2

About us 4

The year 2018 in figures 6

The Foundation

celebrates 10 years fighting against Alzheimer’s ...... 8

The research: the Barcelonaβeta Brain Research Center (BBRC) 1 0

Alpha Study 11

Alzheimer’s Prevention Program 1 2

Clinical Research Group, Biomarkers and Risk Factors 12 Neuroimaging Research Group 13

Edition Pasqual Maragall Fundation Research projects Barcelonaßeta Brain Research Center Foundation 14 Wellington, 30 08005 International collaborations 1 7 +34 933 160 990 [email protected] Clinical trials 1 9 www.fpmaragall.org Principal scientific publications 20

Date of publication May 2019 Conferences and talks 22

Social area: therapeutic groups 24

Fundraising and social support 25

Dissemination 30

Origin and destination of resources 34

Partners 36 Total or partial reproduction of this publication, treatment in any form or by any means, electronic, mechanical, photocopying, recording, or other methods, or its Boards 38 loan, rent or any other form of cession of use of the copy is not allowed without prior written permission of the copyright holder. 2 Greeting Greeting

“I want to help defeat Alzheimer’s. It Barcelona Brain Research Center (BBRC), since this center, with its cutti ng-edge is not easy or simple, but nowhere is more than 2,500 visits in the diff erent infrastructures and a concentrati on of it writt en that it is invincible.”These research projects and clinical trials that indisputable talent, also confi rms, ten were the words pronounced by the we have underway. This involves more years later, the commitment achieved. former mayor of Barcelona and former than 1,200 cogniti on sessions, more than president of the Generalitat of 1,000 nursing sessions, more than 21,000 With wishes fulfi lled and also dreams on October 20th, 2007, when he processed samples, more than 230 to be realized, we conti nue advancing announced that he had been diagnosed lumbar punctures and more than 1,000 thanks to the support of many people with an Alzheimer’s onset. In that press MRI acquisiti ons. and enti ti es that have accompanied conference he also claimed: “I want us throughout this ti me in the to help to advance, as far as I can, the To this intense acti vity we must add the materializati on of that vision. We refer to research on this disease.” This public start, this year, of the Clinical Research enti ti es such as “la Caixa”, the support of commitment materialized in April 2008 Unit in the Preventi on of Dementi a, a which has made it possible to transform with the start-up of the Pasqual Maragall new pioneering research project that what should be a study of 400 people With wishes fulfi lled and Foundati on. studies the risk, and its biological bases, in the current cohort of almost 3,000 also dreams to be realized, of developing dementi a during fi ve people. And to all the enti ti es of our So in 2018 we have commemorated our years. We have also launched the Bio Board of Patronage, which, with their we continue advancing 10th anniversary. And we have done it by Alfa research project, focused on blood fi nancial contributi ons, make our project taking stock and refl ecti ng on the road factors associated with aging and brain viable. And to the more than 24,000 thanks to the support of traveled. It has been a decade of eff ort, rejuvenati on. members who make up the current social many people and entities growth and great moments. All this has base that drives us every day to keep given us more strength and experience, At an internati onal level, we conti nue to improving, since this project belongs to that have accompanied us and has reaffi rmed us in the convicti on consolidate alliances and collaborati ons, each one of them and a hope in which throughout this time in the that, if we conti nue advancing, we will such as the EPAD European project, in all, researchers, workers, volunteers, end this disease. which in 2018 the BBRC was the center collaborators and enti ti es, we believe. materialization of that vision with the most registered parti cipants Jordi Camí Achievements as the excepti onal from all over Europe and AMYPAD, a We close the fi rst decade of our founding General Director of response, in 2012, of more than 6,000 European collaborati on to improve the history and open a new stage with an Thank you for these 10 years! the Pasqual Maragall Foundati on. people, who volunteered for our call knowledge and diagnosis of Alzheimer’s eye on the future, in which, we are sure, to launch the Alfa Study. About 3,000 disease using the PET imaging technique we will have many new achievements to of those people represent now one of (positron emission tomography). celebrate together. the largest study cohorts in Alzheimer’s preventi on in the world. And thanks to This excellent and ti reless task is carried Thank you for these 10 years! their generosity and predispositi on, for out by more than 50 researchers and example, only in 2018, we have been able professionals of the BBRC. And here Jordi Camí to carry out from our research center, the is another reason for celebrati on, Director

2 3 Pasqual Maragall Foundation _ Barcelonaβeta About us Brain Research Center

ALZHEIMER’S TODAY

Every day thousands of new cases The Pasqual Maragall Foundation of dementia are diagnosed in and the Barcelonaβeta Brain Research the world, whose main cause is Center work tirelessly to fi nd a Alzheimer’s It is estimated that in solution We are convinced that the world there are about 50 million research is the only way out And cases of dementia1 and only in prevention is the key to stopping the about 800,000 cases 2 advance of this epidemic:

Every 3 seconds a new case The Pasqual Maragall The Barcelonaβeta of dementi a is diagnosed in the world. IF WE WERE ABLE TO Foundation Brain Research Center DELAY ONLY FIVE YEARS THE START OF With the vision of achieving a future The Barcelonaβeta Brain Research Center THE ALZHEIMER’S, THE without Alzheimer’s, the Pasqual Maragall (BBRC) is a research center dedicated to 1 Of every 10 people Foundati on promotes and develops the preventi on of Alzheimer’s disease and over 65 years old NUMBER OF SICK PEOPLE the ulti mate biomedical research to the study of cogniti ve functi ons aff ected has alzheimer’s. COULD BE REDUCED TO contribute to the decisive soluti ons to this in healthy and pathological aging. It was 3 disease. created in 2012 by the Pasqual Maragall ALMOST HALF Foundati on, with the support of the The objecti ve is to prevent its onset, Pompeu Fabra University. 2050 determining what factors aff ect its start and development, designing interventi ons The mission of the BBRC is to provide to act before it is too late and expanding innovati ve soluti ons to decipher ONE OF EVERY knowledge about the cogniti ve functi ons and prevent biological changes and TODAY Transparency THREE CASES OF and good practice aff ected in aging. cogniti ve dysfuncti on associated with neurodegenerati ve diseases. Its researchers DEMENTIA COULD BE The Pasqual Maragall The Foundati on also works to generate carry out research projects of neuroimaging Foundati on and the PREVENTED MAKING A social awareness about the eff ects of this and primary and secondary Alzheimer’s If an eff ecti ve cure is not found, by 2050 Barcelonaβeta Brain 4 Research Center have disease and the importance of scienti fi c preventi on, and acti vely parti cipate in the number of cases will have tripled. CHANGE OF LIFE HABITS a code of good practi ces research to fi nd soluti ons. studies and internati onal work groups in transparency and focused on the preventi on of the disease. accountability and a code While these soluti ons do not arrive, the of good scienti fi c practi. ce Foundati on is also committ ed to improve In 2018 the Catalan Associati on the quality of life of aff ected people and 1 Data of the World Health Organizati on of Research Enti ti es (ACER) unanimously (WHO). their caregivers . agreed to the incorporati on of the BBRC. 2 Data of the World Alzheimer Report. 3 Data of the Alzheimer’s Associati on Treatment Report: Changing the Trajectory of Alzheimer’s Disease: How a Treatment by 2025 Saves Lives and Dollars. 4 Norton et al. “Potenti al for primary preventi on of Alzheimer’s disease: an analysis of populati on-based data”. Lancet Neurol. 2014 Aug (13);8:788-94. 4 5 L’any en xifres The year 2018 in fi gures*

* Provisional closure of 2018 Aggregated data from the Pasqual Maragall Foundation and the Barcelonaβeta Brain Research Center The two entities are subject to an external 2018 annual accounts audit

Budget 24,508 1,228 48,733 €8,622,166 Members Cognition sessions Social media followers

€4,154,639 121 1,050 Pasqual Maragall Foundation Staff at headquarters Magnetic resonance 1,430 acquisitions Appearances in the media €4,467,527 939 Barcelonaβeta Participants visited 162 Brain Research Center Caregivers participating 113 in therapeutic groups Solidarity actions

6 7 10 Years fi ghting against alzheimer’s The Pasqual Maragall Foundation celebrates 10 years fi ghting against Alzheimer’s

Memories Presentation 10th anniversary gala in Barcelona To commemorate the 10th anniversary, On November 14th, the Pasqual and on the occasion of World On September 20th, the book Recuerdos Maragall Foundati on celebrated its 10th Alzheimer’s Day, on September 21st, the was presented at an event organized anniversary in the company of volunteers Foundati on asked 40 friends of Pasqual by the RBA Foundati on and att ended who parti cipate in its research projects, Maragall to share an unforgett able by more than 800 people. The event partners, sponsors and collaborators, in memory lived with him. The result was brought together on the same stage an emoti onal gala at the Auditorium of the book Records, which the Foundati on Queco Novell, Julia Otero, Margarita the Forum of Barcelona. The event was published with the RBA publishing Obiols and Lluís Bassat, some of the att ended by about 2,000 people. house. 40 friends who have collaborated with their stories in the reconstructi on of the During the ceremony, the main It is an acknowledgment to the fi gure of memories that make up the book. achievements of the Foundati on’s Pasqual Maragall in which personaliti es 10-years history were exposed, such from the politi cal, business and cultural as the launch of the Alfa study and the BBRC, promoted thanks to the strong world, as well as personal friends and Presentation in Madrid collaborators, evoke special memories support of “la Caixa”. lived with the former president of the On November 28th, the book Recuerdos Generalitat and ex-mayor of Barcelona. The music also had a prominent role at was presented at the CaixaForum of the gala, with the performances of T o ti Madrid. María Teresa Fernández de Lluís Bassat, Jordi Basté, Carmen Soler, Gemma Humet and Joan Dausà, la Vega, Federico Mayor Zaragoza and , Cervera, , Odón Elorza, Jordi and a conference dedicated to the eff ect Santi ago de Torres shared the stage in 2018 has been a year of celebrati on Years later, this materialized in the .Évole, Isidre Fainé, Javier Mariscal, and associated memories that music Perfume “és possible” an event directed by journalist Marta for the Pasqual Maragall Foundati on. insti tuti on that bears his name as well Mayte Martí n, Federico Mayor Zaragoza, can generate in healthy people and by Eurofragance Solano, with more than 200 att endees. On his 10th anniversary, the as in a pioneering research center in Eduardo Mendoza, Queco Novell, Alzheimer’s pati ents. Foundati on remembered the vision On the occasion of the 10th the world. Also in the main task of the Margarita Obiols, Julia Otero, Sílvia anniversary, Eurofragance, one of and determinati on of its founder, the professionals who work there which Pérez Cruz, Richard Rogers and Mònica the enti ti es of the Patronage Council, former mayor of Barcelona and former became the hope of many people. Terribas are some of the 40 friends who created the perfume “és posible”, president of the Generalitat Pasqual Therefore, the acts of celebrati on parti cipate with their stories in the book inspired by the values and principles Maragall. At the press conference held of these fi rst 10 years of life of the published on the occasion of the 10th of the Pasqual Maragall Foundati on: on October 20th, 2007, he said he Foundati on have wanted to involve all anniversary of the Foundati on. energy, opti mism, innovati on, wanted to beat Alzheimer’s, because those who share the vision of a future creati vity, aff ecti on, warmth, scienti fi c nowhere it was writt en that Alzheimer’s without Alzheimer’s. Thanks to everyone. rigor and social responsibility. The perfume, which was given to those should be invincible. Because together, it is possible. att ending the gala, also symbolizes With the support of the strong relati onship between smell and memory.

8 9 Research Alfa Study The research The Barcelonaβeta Brain Research Center (BBRC)

ALPHA STUDY

The objecti ve of the Alpha Study is to collect informati on that will allow identi fying biomarkers and risk factors to understand the natural history of the disease and to design strategies for the preventi on of Alzheimer’s disease.

In 2018, the BBRC visited 939 parti cipants, the majority coming from the Alfa Study, launched in 2013 thanks to the support of Activity of The Barcelona βeta “la Caixa”. Brain Research Center in 2018 The Alfa Study is one of the research platf orms dedicated to the early detecti on and preventi on of Alzheimer’s with a greater number of parti cipati ng volunteers Participants than exists in the world. It is made up of visited 21,339 2,743 cogniti vely healthy parti cipants, 939 Total samples processed between 45 and 75 years old, most of whom are children of Alzheimer’s pati ents.

All the parti cipants perform a series of tests Total visits made Nursing sesions (cogniti on test, clinical history, life habits 2,594 1,031 and, some, an MRI) in the fi rst visit, and then, depending on their characteristi cs and 1,228 Cognition sessions 232 Lumbar punctures availability, they are invited to parti cipate in research projects linked with additi onal tests. 896 Clinical sessions 340 PET tests Alpha Study has the support of Thanks to these tests, which are carried out PET FTM 188 periodically, our researchers have already 12 Study protocols 152 PET FDG published relevant advances in presti gious scienti fi c journals.

10 11 Research Research Alzheimer’s Alzheimer’s Prevention Program Prevention Program

ALZHEIMER’S Clinical Research PREVENTION Group, Biomarkers PROGRAM and Risk Factors The Clinical Research Group, Biomarkers The BBRC Alzheimer’s Prevention and Risk Factors is formed by a Program focuses on the preclinical phase multidisciplinary team of experts in of the disease, which is characterized by the field of genetics, clinical practice, a series of changes in the brain that can biomarkers and neuropsychological start up to 20 years before the onset of evaluation. Led by Dr. José Luis Molinuevo, symptoms, and in the prodromal phase, they investigate the biological processes which occurs when the first symptoms of that precede the onset of dementia, in cognitive deterioration appear, but the order to establish prevention programs. affected person remains independent in his day to day life. The program is led by Dr. José Luis Molinuevo and is structured Lines of investigation: in two research groups that collaborate closely from a clinical, cognitive, genetic • Association between subtle cognitive and biological markers and neuroimaging impairment, subjective perception and perspective. brain changes and related objective Neuroimaging cognitive performance. Research Group • Association between sleep disorders, The Neuroimaging Research Group focuses The members cognitive impairment and Alzheimer’s of the BBRC Neuroimaging disease. on the study of brain images obtained by Research Group magnetic resonance and positron emission • Role of pro-rejuvenation and aging blood tomography to reveal characteristics risk factors in Alzheimer’s disease. associated with healthy aging and risk • Personalized study of the risk of factors for Alzheimer’s disease. The group, developing dementia in order to offer led by Dr. Juan Domingo Gispert, is formed personalized prevention plans. by a multidisciplinary team expert in the acquisition, processing and analysis of • Epidemiological studies on the role of complex neuroimaging data. pollution, anxiety, depression and other factors in Alzheimer’s. Lines of investigation: • Role of vascular risk factors in the pathophysiology of Alzheimer’s. • Cerebral correlations of the preclinical • Effect of dietary intake of omega-3 phase of Alzheimer’s disease and risk fatty acids in the preclinical phase of factors. Alzheimer’s. • How to improve the use of positron • Multimodal interventions for the emission tomography images of amyloid prevention of cognitive deterioration. in the clinical setting and in Alzheimer’s research. • Genetic determinants of brain phenotypes. • Development of new techniques to detect the preclinical phase of Alzheimer’s disease. Team of Clinical Research • Generation of a repository of images Group, Biomarkers and Risk Factors from BBRC. of the preclinical phase of Alzheimer’s disease.

12 13 Research Recerca Research projects Projectes de recerca

RESEARCH PROJECTS Bio Alfa Alfa+ Bio Alfa is a new research project, Alfa + is a cohort study to identify Clinical Research Unit in The project offers participants a also started in 2018, with the aim of the factors that favor the onset of the Prevention of Dementia customized and individualized action investigating whether certain blood factors Alzheimer’s disease and other aspects, plan to try to reduce their risk of that have been associated with aging or such as the age of onset, the most The Clinical Research developing dementia. This plan consists brain rejuvenation in mice can become frequent symptoms and how these of a series of advice aimed at reducing potential future therapeutic targets in factors act on cognitive ability and in the Unit in the Prevention the modifiable risk factors of the humans to fight the disease of Alzheimer’s brain. of Dementia is a new disease and provides for the possibility and other dementias. of offering participation in specific In 2018, 361 visits were made to 122 pioneering research studies of detection and prevention of The presence of these blood markers will participants. The project will involve a project that studies Alzheimer’s to those people who meet be measured in the Alfa Study participants total of 450 people without cognitive the corresponding requirements. and in other interest groups, such as impairment, who perform different tests the risk, and its adolescents, young people up to 25 years every three years such as, for example, biological bases, In addition to investigating if there is old and people over 70. In addition, thanks cognitive tests, a lumbar puncture to a biological basis associated with the to a collaboration agreement with the remove cerebrospinal fluid and two of developing dementia calculated risk algorithm, the project Blood Bank and Tissues, blood samples magnetic resonances. five years after. also studies the possible emotional from the umbilical cord will also be impact that the fact of individually analyzed. revealing this risk percentage may have, The Memory Program of the BBRC The study was launched in May 2018, PET is dedicated to different aspects and has an expected duration of three as well as the benefits that may be In 2018, a total of 60 participants were techniques applied to research in years and will incorporate some 400 derived from participation in the study. visited, who went to the headquarters Most of the Alfa + Study participants are cognition, memory and human behavior participants between 60 and 80 years of the Pasqual Maragall Foundation to in ecological conditions. After the recruitment phase of the study, also invited to perform two sessions of old who are experiencing a decrease have a blood extraction and provide basic positron emission tomography (known which was done through an online form, demographic data. The program, led by Dr. Luis Martínez- in memory or other cognitive abilities, visits began in July 2018. From then as PET), at the facilities of the Hospital Otero, began in late 2017 and will end but who have not been diagnosed Clínic in Barcelona. The objective is to be until the end of the year, 253 visits were The research is led by Dr. Marc Suárez- in 2019. It is structured in two groups: Alzheimer’s disease or any other form of able to analyze these images to improve the Decisions, Emotions and Memory made to 81 participants. Calvet, under the direction of Drs. José dementia or disease that justifies it. the detection of Alzheimer’s disease in Research Group, led by Dr. Martínez- Luis Molinuevo, at the Barcelonaβeta Brain its preclinical phase. Otero, and the Research Group on Neural Research Center, and Kaj Blennow, at the Mechanisms of Memory, headed by Dr. Rodrigo Quian-Quiroga, visiting Sahlgrenska Academy of the University of In 2018, 188 PET of 18F-flutemetamol researcher of the BBRC. Gothenburg. The Bio Alfa is financed with were performed, to show the amount the Marie Skłodowska-Curie grant number and location of the amyloid protein, and 752310, as part of the European Union’s 152 PET of 18F-FDG, to see which brain Horizon 2020 research and innovation areas are more or less active. program.

14 15 Research Research Research projects International collaborations

INTERNATIONAL COLLABORATIONS Alfa Genetics that will parti cipate in the project. follow-up of parti cipants promoted Parti cipati on in the study involves the changes in life habits related to EPAD It has only been possible to reach these Alfa Geneti cs is a transversal study performance of neurological tests, cardiovascular risk factors and fi gures of 2018 thanks to the great with the aim of expanding the neuroimaging, cogniti ve tests and life dementi a, as well as analyzing the eff ort and moti vati on of our team”. cogniti ve, geneti c and cerebral The European Preventi on of Alzheimer’s habits, and a blood extracti on in order possible associati on with changes in Dementi a Consorti um (EPAD) project was characterizati on of people without to rule out any conditi on that may objecti ve physiological variables. The EPAD is funded by grant number cogniti ve impairment of the Alpha established in 2015 and consists of 38 cause cogniti ve impairment. European insti tuti ons, including the BBRC. 115736 of the Innovati ve Medicines Study to improve knowledge of Initi ati ve, which is a joint initi ati ve of the molecular basis of Alzheimer’s Its objecti ve is to expand the knowledge of the preclinical phase of Alzheimer’s disease the research and innovati on program disease, as well as to identi fy new NPAD study of the European Commission Horizon biomarkers and risk factors. Alfa Life and develop an infrastructure that allows The Neurofeedback for the Preventi on carrying out concept tests to accelerate 2020 and the European Federati on of Pharmaceuti cal Industries and During 2018, 376 parti cipants of the Alfa Life is a program of control of Alzheimer’s Disease (NPAD) study decision-making in the development of Associati ons (EFPIA). total of 1,700 that will be part of the and interventi on on the modifi able ended in 2018 and is in the phase of candidate drugs to prevent the disease. project were visited. Aft er updati ng risk factors of Alzheimer’s disease analysis of results. The project, led by The EPAD ended in 2018 with more than the clinical history and cogniti ve status through the promoti on of healthy Dr. Stavros Skouras, combined virtual 1,300 parti cipants recruited in 21 European of the study parti cipants, they are reality and neurofeedback to establish lifestyle habits and the control of centers. The BBRC was the center with given an MRI, an odor identi fi cati on associati ons between performing a cardiovascular risk factors. the most registered parti cipants in all of test and a blood sample to determine series of brain training tasks and the Europe. In total, the operati ons team of basic biochemical variables, as well as In 2018 the last 36 parti cipants of presence of certain biomarkers and the Pasqual Maragall Foundati on research to carry out a geneti c analysis. the total of 409 people who have other data related to Alzheimer’s center carried out 893 visits to nearly been part of the study were visited. disease. 200 parti cipants during the year, who did For one year, all parti cipants received regular check-ups, cogniti ve, geneti c and a series of personalized guidelines In the year 2018 the last three Alfa Cognition MRI tests, as well as a blood, saliva, urine and ti ps for the promoti on of healthy parti cipants without cogniti ve and cerebrospinal fl uid extracti on. living habits in the areas of nutriti on, alterati on from the Alfa Study were Alfa Cogniti on is an observati onal and visited. In total, about a hundred physical exercise and cogniti ve and Dr. Karine Fauria, manager of scienti fi c prospecti ve study that analyzes the people have parti cipated in the social acti vity, completed a series of resources of the BBRC, points out: “The relati onship between the subjecti ve project. The NPAD has been fi nanced percepti on of cogniti ve decline follow-up questi onnaires and were EPAD is the most complex observati onal visited twice in the headquarters of with the Marie Skłodowska-Curie study we do, and we have even had to and the presence, evoluti on or grant number 707730, as part of the Pasqual Maragall Foundati on. The design specifi c procedures to carry it out. risk of clinically objecti ve cogniti ve the European Union’s Horizon 2020 results of the analysis were presented deteriorati on. It also analyzes the research and innovati on program. relati onship of these parameters with at the Spanish Society of Neurology, the brain changes associated with by Dr. Nina Gramunt. Alzheimer’s disease. The results of the study will allow In 2018, 56 visits were made to researchers to assess whether the 36 parti cipants, of the total of 200 delivery of these guidelines and the

16 17 Research Research International Clinical trials collaborations

AMYPAD TRIBEKA

The Amyloid Imaging to Prevent TRIBEKA is an initiative of the BBRC and the Alzheimer’s Disease (AMYPAD) is a University of Edinburgh driven to identify European project constituted in 2016 the brain alterations prior to the onset of and formed by 17 European institutions, the symptoms of Alzheimer’s disease and among which is the BBRC. Its objective is other neurodegenerative diseases. to improve the knowledge, diagnosis and treatment of Alzheimer’s through the use The mission of this consortium is to of a cerebral amyloid PET. generate an open access neuroimaging platform that allows offering broadly The project consists of different parts: a characterized information to advance in diagnostic study to determine the value the design of new treatments. During of amyloid PET, another of prognosis to 2018, the research team and the data CLINICAL TRIALS better understand the natural history of center of the BBRC worked to make the disease in coordination with the EPAD available to the global scientific community project and a proof of concept in which the information gathered in the project, The BBRC works with the pharmaceutical Generation S2 models of evolution of the disease will be through the Global Alzheimer’s industry and public-private projects in build. Association Interactive Network (GAAIN). order to test drugs that prevent or delay It evaluates the effects and safety of the onset of Alzheimer’s disease. a drug (CNP520) on the cognition and During 2018, the BBRC team participated overall clinical status of people at risk in different project working groups and Active clinical trials in the BBRC, on of developing clinical symptoms of established the procedures required to December 31st, 2018: Alzheimer’s disease according to their age, initiate the recruitment of participants for genetic predisposition and amyloid protein the diagnostic study. load in the brain. The trial plans to recruit Generation S1 2,000 people from around the world, AMYPAD is funded by grant number committed to continue treatment between 115952 of program 2 of the Innovative 17 people It analyzes the efficacy of two drugs five and seven years. In 2018, Medicines Initiative, which is a joint were visited (CAD106 and CNP520), administered in the BBRC to assess their initiative of the research and innovation 13 separately, to delay the onset and possible inclusion in the project, and program of the European Commission followed the treatment progression of clinical symptoms associated . Horizon 2020 and the European Federation With the support of with Alzheimer’s disease, in participants of Pharmaceutical Industries and at risk of developing symptoms. The trial Associations (EFPIA). envisages recruiting 1,340 participants AB1601 around the world, committed to continue the treatment for five and eight years. In It evaluates the efficacy, safety, tolerability AMYPAD is funded by 2018, 60 people were visited in the BBRC and immune response of a drug (ABvac40) grant number 115952 of to assess their possible inclusion in the in people between 55 and 80 years old In the year 2018, four clinical trials program 2 of the Innovative project, and 10 followed the treatment. were carried out: Generation S1 Medicines Initiative, which with mild amnestic cognitive impairment and Generation S2 by Novartis, EARLY is a joint initiative of the or in very early stages of Alzheimer’s by Janssen and AB1601 by Araclon research and innovation disease. The study plans to include 200 Biotech (Grifols). The promoter program of the European participants, from mostly Spanish centers, of the EARLY study suspended Commission Horizon 2020 the clinical trial in June after analyzing and the European Federation but also from France, Italy and Sweden, the performance and risk-benefit of Pharmaceutical Industries who will continue the treatment for 42 of the drug, which was aimed to and Associations (EFPIA). weeks. In 2018, two people were visited at delay the onset of cognitive decline the BBRC to assess their possible inclusion in people at risk of developing the in the project, and one followed the disease. In the BBRC, no participant treatment. initiated the treatment.

18 19 Research Research Principal Principal scientific publications scientific publications

PRINCIPAL SCIENTIFIC PUBLICATIONS In 2018, the BBRC F, Karlawish J, Liu E, Molinuevo JL, Hampel H, O’Bryant SE, Molinuevo Montine T, Phelps C, Rankin KP, Rowe JL, Zetterberg H, Masters CL, Lista S, researchers CC, Scheltens P, Siemers E, Snyder Kiddle SJ, Batrla R, Blennow K. Blood- published 47 articles HM, Sperling R; Contributors. NIA- based biomarkers for Alzheimer AA Research Framework: Toward a disease: mapping the road to in prestigious biological definition of Alzheimer’s the clinic. Nat Rev Neurol. 2018 New study on cerebral international disease. Alzheimers Dement. 2018 Nov;14(11):639-652. structure alterations Apr;14(4):535-562. scientific journals. Cacciaglia R, Molinuevo JL, Sánchez- In March 2018 we announced that, thanks to Operto G, Cacciaglia R, Grau O, Falcón Benavides G, Falcon C, Gramunt N, the Alfa Study, we have been able to detect Nineteen of these articles were led by C, Brugulat-Serrat A, Ródenas P, Ramos Brugulat-Serrat A, Grau-Rivera O, morphological alterations in the cerebral gray matter the BBRC and published in magazines R, Morán S, Esteller M, Bargalló N, Gispert JD. Episodic Memory and of people without cognitive alteration carrying the of the first decile (45%) and the first Molinuevo JL, Gispert JD. White matter Executive Function in cognitively quartile (89%). These are some of the microstructure is altered in cognitively Healthy Individuals Display Distinct variant of the gene that confers the greatest genetic principal publications: normal middle-aged APOE-ε4 Neuroanatomical Correlates which risk of developing Alzheimer’s, the APOE-Ɛ4. It is homozygotes. Alzheimers Res Ther. are Differentially Modulated by the study with the largest number of carriers of this Rojas S, Brugulat-Serrat A, Bargalló 2018 May 24;10(1):48. Aging. Hum Brain Mapp. 2018 variant in the world who did an MRI. N, Minguillón C, Tucholka A, Falcon Nov;39(11):4565-4579. C, Carvalho A, Morán S, Esteller Cacciaglia R, Molinuevo JL, Falcón M, Gramunt N, Fauria K, Camí J, C, Brugulat A, Sánchez-Benavides Molinuevo JL, Ayton S, Batrla R, Molinuevo JL, Gispert JD. Higher G, Gramunt N, Esteller M, Morán S, Bednar MM, Bittner T, Cummings J, prevalence of cerebral white matter Minguillon C, Fauria K, Gispert JD. Fagan AM, Hampel H, Mielke MM, hyperintensities in homozygous Effects of APOE-ε4 allele load on Mikulskis A, O’Bryant S, Scheltens P, APOE-ɛ4 allele carriers aged 45- brain morphology in a cohort of Sevigny J, Shaw LM, Soares HD, Tong G, New research on microstructural 75: Results from the ALFA study. middle-aged healthy individuals with Trojanowski JQ, Zetterberg H, Blennow changes in the brain J Cereb Blood Flow Metab. 2018 enriched genetic risk for Alzheimer’s K. Current state of Alzheimer’s fluid Feb;38(2):250-261. disease. Alzheimers Dement. 2018 biomarkers. Acta Neuropathol. 2018 In June 2018, we published another study on Jul;14(7):902-912. Dec;136(6):821-853. APOE-Ɛ4, in which we revealed that participants Molinuevo JL, Minguillon C, Rami with this gene presented microstructural changes The rationale behind L, Gispert JD. Sánchez-Benavides G, Grau-Rivera Sánchez-Benavides G, Grau-Rivera in the cerebral white matter, independent of the the new Alzheimer’s disease O, Cacciaglia R, Suárez-Calvet M, O, Suárez-Calvet M, Minguillon C, changes related to age. conceptualization: lessons learned Falcon C, Minguillón C, Gramunt N, Cacciaglia R, Gramunt N, Falcon C; during the last decades. J Alzheimers Gispert JD, Molinuevo JL. Distinct ALFA Study, Gispert JD, Molinuevo Dis. 2018 Mar;62(3):1067-1077. Cognitive and Brain Morphological JL. Brain and cognitive correlates Features in Healthy Subjects Unaware of subjective cognitive decline-plus Jack CR Jr, Bennett DA, Blennow of Informant-Reported Cognitive features in a population-based K, Carrillo MC, Dunn B, Haeberlein Decline. J Alzheimers Dis. 2018 cohort. Alzheimers Res Ther. 2018 Dec SB, Holtzman DM, Jagust W, Jessen Aug;65(1):181-191. 20;10(1):123. Pioneering study on the role of the closest relatives In September 2018 we discovered that the closest relatives of people at risk of being in the preclinical phase of Alzheimer’s disease, during which there are no symptoms, can perceive changes that may be relevant and go unnoticed by the affected person. The research was conducted on 2,640 participants of the Alfa Study.

20 21 Research Research Conferences and talks Conferences and talks

CONFERENCES AND TALKS

Throughout the year our research staff has been participating in conferences and research congresses.

September 20th, Barcelona. Participation José Luis Molinuevo gives the Participation of the BBRC Other principal of Dr. Nina Gramunt in the X Patient inaugural conference of the in the Congress of conferences congress. Congress of Alzheimer Europe Dr José Luis Molinuevo giving the Alzheimer’s Association his lecture at the Alzheimer Europe Conference. January 19th, Miami (United States). September 21st, Barcelona. Participation The scientific director of the Alzheimer’s The BBRC researchers presented the latest Participation of Gemma Salvadó in the of Drs. Nina Gramunt and Gema Huesa at Prevention Program of the BBRC, Dr. Barcelona Olfaction Congress developments of the Alfa Study and the Human Amyloid Imaging congress. the . José Luis Molinuevo, gave the inaugural Clinical Research Unit in the Prevention of lecture of the Alzheimer Europe Dementia in the world’s most important March 16th, Turin (Italy). Participation of October 24th, Hamburg (Germany). Conference, on October 29 in Barcelona. BBRC’S team at the Participation of Drs. Karine Fauria and In the presentation “Will we be able to International Congress of conference in the field of Alzheimer’s Dr. José Luis Molinuevo in the Advances in Alzheimer’s Association. research, the Alzheimer’s Association Alzheimer’s and Parkinson s Therapies: an Nina Gramunt at the Transnational prevent Alzheimer’s?” he addressed the Integrated Community International Conference (AAIC), held on AAT-AD / PD Focus Meeting. Conference on challenges and opportunities related to Care 22nd to July 26th in Chicago. . the prevention of the disease. April 17th, Buenos Aires (Argentina). Participation of Dr. José Luis Molinuevo in October 24th, Barcelona. Participation a satellite conference of the Alzheimer’s of the BBRC team in the Clinical Trials on Association. Alzheimer’s Disease (CTAD) congress.

May 25th, Barcelona. Participation of Dr. October 25th, Lisbon (). Gonzalo Sánchez in the XI Barcelona- Participation of Dr. Sandra Poudevida Pittsburgh Biennial Conference. in the 1st International Congress of Inclusive Social Responses. June 13th, Las Palmas de Gran Canaria. Participation of Dr. Sandra Poudevida in December 18th, Bangalore (India). the National Congress of the Spanish Participation of Dr. José Luis Molinuevo in Society of Geriatrics and Gerontology. a satellite conference of the Alzheimer’s Association. July 2nd, Kyoto (Japan). Participation of Dr. José Luis Molinuevo in the World Congress of Basic and Clinical Pharmacology.

July 7th, Toulouse (France). Participation of Dr. Stavros Skouras in a satellite event of the Euroscience Open Forum.

22 23 Social area: Fundraising and therapeutic groups social support

24,508

Evolution of the number of members:

16,863 The program of of people with illness, an online training program for therapists, whose therapeutic groups development began in 2017 together promoted in the year with “la Caixa” and the Insti tute of 2018 the creation of Conti nuous Training of the . 8,947 16 new groups in which 162 caregivers of people The training, which has the 4,863 characteristi cs of an online university aff ected by Alzheimer’s extension, is certi fi ed with 3 ECTS 2,059 participated. credits and is structured in 67 hours online self-learning and 8 contact hours. 2014 2015 2016 2017 2018 These groups received the support of the Generalitat of Catalonia, the Provincial Council of Girona and the In 2019, the social area will Provincial Council of Barcelona, and With the support of become part of the Pasqual four of them were fi nanced by the Network of partners presentati on of the Clinical Research Maragall Foundati on’s own subsidy granted by the Ministry of Unit in the Preventi on of Dementi a was project. Since the beginning, Health, Social Services and Equality, and donors made in the faciliti es of the research in 2012, 577 caregivers have charged to the tax assignment of the center. parti cipated in the 57 free personal income tax. The diff erent In 2018 the network of partners Giving Tuesday. In 2018 the Pasqual therapeuti c groups that have groups were carried out in Barcelona, 7,645 new associates grew by , who Maragall Foundati on has again taken place in centers throu- Girona, Cornellà de Llobregat, Galicia, contributed €650,706. With this joined #GivingTuesday, the global ghout Spain. Tenerife, Madrid and Andalusia. increase, 24,508 members were solidarity movement that celebrates The mission of the therapeuti c The results of the Cuidamos study, reached, representi ng a total annual €2,940,540 the importance of giving. groups is to off er informati on promoted by the Pasqual Maragall contributi on of . As for 1,362 donati ons and resources to facilitate the Foundati on with the support of “la the donors, were Internati onal Day of the Solidarity understanding and acceptance Caixa” and the collaborati on of the received, which meant an income of Legacy. On the occasion of the €135,476. of the disease by the caregi- Spanish Alzheimer’s Confederati on Internati onal Solidarity Legacy Day, vers. Throughout the sessions, (CEAFA), were presented at the 59th Claβ. It currently consists of 65 on September 13th the Foundati on they are provided with tools to Congress of the Spanish Society of members who contribute an annual joined the campaign promoted by live with Alzheimer’s pati ents Geriatrics and Gerontology in June. contributi on of €78,782. The Claβ Solidarity Legacy under the slogan and reduce the impact that off ers its members the opportunity to #CambiaLosTitularesDelFuturo, focused derives from their role as ca- In 2018 was also launched the Course learn fi rst-hand about the Alzheimer’s on informing the society about the regivers. of conducti ng therapeuti c groups and counseling for family caregivers preventi on projects we develop. With possibility of donati ng in a will to a this objecti ve, on July 25 a private charitable cause.

24 25 Fundraising Fundraising and social support and social support

2nd edition of Solidarity Xmas Tree Promoted by the Paseo de Gracia Commerce Associati on, Solidarity actions the research on Alzheimer’s promoted the initi ati ve raised more than €100,000 for the diff erent by the Pasqual Maragall Foundati on. research projects of the Pasqual Maragall Foundati on and the These acti ons, a total of 113 initi ati ves, Pequeño Deseo Foundati on. The collecti on was the result of During 2018 there were numerous meant an income of €147,577, €21,000 the aucti on of 13 Christmas trees created by the luxury brands acti ons, events and solidarity acti viti es from a donati on from the Atrevia Alfons & Damian, Brunello Cucinelli, Carti er, Castañer, Christi an promoted by enti ti es and individuals communicati on agency and nearly Loubouti n, Ermenegildo Zegna, ETRO, Loewe, Luzio, Lydia with the aim of raising funds to advance €2,000 from other support acti ons. Delgado, Natura Bissé, Rabat and Santa Eulalia . The aucti on took place during a charity gala held at the Majesti c Hotel & Spa in Barcelona, which brought together representati ves of Catalan civil society and business life in Barcelona.

Solidarity fundraising campaign “Céntimo a céntimo, hacemos memoria”, in Viena restaurants Solidarity entities The TRAM team makes The initi ati ve, the result of a collaborati on agreement a solidarity video at Christmas between the Catalan start-up Worldcoo and the Viena Almost 40 TRAM workers parti cipated dancing in catering establishments, was launched in November Espai GironÈs promotes an innovative a solidary video in benefi t of the Pasqual Maragall 2018 to raise funds in favor of research campaign against Alzheimer’s Foundati on. The initi ati ve, which achieved more than into Alzheimer’s disease. With the rounding-up 200,000 views, raised €10,000 for the enti ty. “Message to space. For a future that everyone of all the amount of orders paid by card, Viena has remembers “is the name of the campaign that Espai raised more than €200,000 as we publish this editi on. Gironès carried out from December 1st, 2018 to All the money raised in this collaborati on with Viena Solidarity Insurance Award January 5th, 2019 for the benefi t of the Pasqual will be allocated, enti rely, to the new Clinical Research MetLife, a leading company in life and accident Maragall Foundati on. Sponsored by the musician Pep Unit in the Preventi on of Dementi a, promoted by the insurance worldwide, gave the Pasqual Maragall Poblet and the actor, director and theatrical author Barcelonaβeta Brain Research Center, the research Foundati on one of the solidarity awards organized by Martí Peraferrer, the campaign launched diff erent center of the Pasqual Maragall Foundati on. INESE. The award, with a value of €4,500, will go to acti ons with which it was possible to raise €10,000 for the Alfa project. the research against Alzheimer’s.

Campaign “Healing Smiles” On November 22nd, 2018, Mútua de Granollers presented the 4th editi on of the campaign “Healing Smiles”, which allocates all funds raised to the research of Alzheimer’s disease of the Pasqual Maragall Foundati on. Throughout 2018 and 2019, the enti ty has organized several acti ons to raise funds, such as SMS to 28058 the sale of lott ery of the enti ty and solidarity bracelets, Thanks to the collaborati on of talks on the disease, handball matches, etc., as well as Movistar, Vodafone, Orange, Yoigo and a “row zero” in the Mútua party so that companies and Euskaltel, through our SMS numbers associates could make a donati on to the Foundati on. 28058 (€1.2) and 38058 (€6) in 2018 we received an income of €5,321

26 27 Fundraising Fundraising and social support and social support

Solidarity entities “fashion with cause”, on the importance of research against Alzheimer’s to overcome the disease.

Solidarity opening Solidarity Football 7 Tournament of the Yurbban Passage Hotel San Cristóbal de Entreviñas (Zamora) hosted the Yurbban Hotels joined the fight against Alzheimer’s IV Football 7 Tournament “For a Future without due to the opening of its new Yurbban Passage hotel Alzheimer’s”, organized by Obra Social CGB, the City Solidarity Challenge: in Barcelona. With this initiative, it raised €4,000 Council and “Amigos Quintos del 66”. Challenges Ultratrail of Cappadocia for the benefit of the Pasqual Maragall Foundation, and solidarity sports specifically 1% of the profits obtained from all its The researcher Francisco Câmara raised more 1,000 people participate in direct sales between April and December 2018. than €4,000 and successfully completed the the VI Solidarity Gala “We are one” ultratrail of Cappadocia. All for his mother, On June 7th, the Espanyol stadium hosted the solidary The Pasqual Maragall Foundation affected by Alzheimer’s, and in favor of the Remember me: fashion gala “We are one”, which was presented again by the already has a flag on Kilimanjaro research carried out by the Pasqual Maragall for a future without Alzheimer’s actor Santi Millán. The gala, as well as the football The adventurer from Puerto Llano (Ciudad Real) Foundation. The solidarity and sustainable fashion brand Uttopy tournament held the previous day and the solidarity Laura Parrilla raised the double challenge of raising launched the new collection “Remember me”, paddle tennis tournament held on June 14th, were funds for Alzheimer’s research and reaching the top Charity Spinning Masterclass designed with the collaboration of the ELISAVA design organized for the benefit of the Pasqual Maragall of Kilimanjaro. All this for his grandfather Paco. The Estefanía Ruiz got 100 people to pedal in favor of school. T-shirts and accessories for men, women and Foundation, Aura, the Social Work of the Hospital Sant result: top crowned and more than €3,000 raised the Pasqual Maragall Foundation at the DreamFit children to sensitize younger generations, through Joan de Déu and the Damm Foundation. for the benefit of the Pasqual Maragall Foundation. in Madrid.

Solidarity celebrations Solidary schools

Around fifty brides and grooms • The Capitol School of L’Hospitalet opt for a “memory against oblivion” in 2018 de Llobregat dedicated its Thanks to all the couples who decided to give personalized postcards of the Foundation, Christmas gala to the Pasqual more than €10,000 were collected, which will be used entirely for research to prevent Maragall Foundation. Alzheimer’s disease. • On December 14th, the Patufet Children’s School Two birthday gifts to remember organized the 5th edition of the Ruzafa Solidarity Tour Michael Goldenberg and Miriam Tarre asked as a gift in their respective anniversaries of Valencia, this year in favor of the a donation in favor of the Pasqual Maragall Foundation. Initiatives that raised more than Pasqual Maragall Foundation. €8,000 to continue researching the prevention of Alzheimer’s. • The fifth grade pupils of the Canigó Public School of Sant Just Desvern A very special communion gift organized a solidarity market for Daniel, aged nine, asked that his communion gifts be a donation to the Pasqual Maragall Alzheimer’s research. Foundation and research to prevent this disease, which his grandmother suffers.

28 29 Dissemination Dissemination

The blog “Let’s talk about Alzheimer’s” is launched The Pasqual Maragall Foundati on launched the blog “Let’s talk about Alzheimer’s”, a tool endorsed by scienti sts, experts and professionals 1st edition of the Brain Film Fest to involve the populati on and raise awareness among of the Barcelonaβeta Brain Research Center, the and delivery of the 8th Solé Tura Prize the competent bodies on the need to provide more Foundati on’s research center, to collect specialized resources for Alzheimer’s research, reached in 2018 From March 15th to 18th, the 1st editi on of the Brain a cumulati ve total of 160,462 signatures. informati on about this disease. Its objecti ve is to be Film Fest was held, of which the Pasqual Maragall a tool at the service of aff ected people, relati ves and Foundati on is a promoter and co-organizer. It is a caregivers, and also of those who seek proven and new internati onal fi lm festi val dedicated to show 4th edition of “Put the heart quality informati on on Alzheimer’s. and promote the creati on and diff usion of short to take care of the brain” fi lms about any aspect of the brain, its incredible Once again, in the framework of World Day of the Campaign “Streets in white” capabiliti es or also its diseases. In additi on, on March 18th, within the framework of the festi val itself, the Elderly, the Foundati on organized, in collaborati on During four days, from September 19th to 22nd, VIII Solé Tura Prize was awarded, to which 220 works with “la Caixa” and the DiR Clubs, the “Put the heart and in the framework of the World Alzheimer’s from all over the world were presented. to take care of the brain” day. This event, in which 200 Day that is celebrated every year on September people parti cipated, aims to promote physical exercise 21st, the plaques of 10 streets and a square in the The initi ati ve brought together more than 2,000 and healthy lifestyle habits. Ópera neighborhood of Madrid were covered to people who could enjoy all the acti viti es programmed make pedestrians put themselves in the skin of a in the Brain Film Fest: three feature fi lms out of Brain Week person with Alzheimer’s and experience one of their competi ti on, 28 short fi lms to compete, the acti vity symptoms: disorientati on. framed in the CCCB Alzheimer Program, a debate, two For the second consecuti ve year, the Pasqual Maragall workshops and two talks as parallel acti viti es. Foundati on and the Barcelonaβeta Brain Research This campaign sponsored by “la Caixa”, which Center have joined the acti viti es organized in was already carried out in Barcelona in 2017, Barcelona for the World Brain Week, which took place Signature campaign “Signing also consisted of a video and acti vity on social from March 12th to 16th. In the framework of the for a future without Alzheimer’s” networks under the hashtags #CarrersEnBlanc Week, Dr. Nina Gramunt, scienti fi c coordinator of the and #CallesEnBlanco, in order to generate greater More than 105,000 people joined in 2018 to the Social Interventi on Area, gave the talk “Put the heart disseminati on and raise awareness among signature campaign launched by the Pasqual Maragall to take care of the brain”, on March 12th and 14th, the populati on about the disease and the need Foundati on in April 2017. This initi ati ve, which aims at the Joan Coromines Insti tute in Hostafrancs. to boost research.

30 31 Dissemination Dissemination

Conferences and talks monographic training program for Contemporary Iberian “Cuídate para cuidado”, by Studies, at the Faculty of Law January 17th. Informative Dr. Sandra Poudevida, at CAP of the University of Barcelona. talk in the PRBB by Dr. Nina Larrard. September 25th. Gramunt. Talk by Dr. April 9th. Participation of Sandra Poudevida on the January 23rd. Talk by Dr. Nina Dr. Nina Gramunt in the importance of psychological Gramunt on the prevention of round table “Aging, services, care to caregivers of people Alzheimer’s at the Avan center housing, energy poverty”, in with Alzheimer’s, at the Sanitas in Sabadell. the framework of the TransJus Sarrià day center in Barcelona. “From Bubble - Research Center opened their doors. A total Conference “Aging, city and of 30 volunteers from their teams showed the September 29th. Barcelona for Alzheimer’s” January 30th. 1st session of the rights”, at the University of Participation approximately 200 attendees the facilities where Humanistic Dialogues of the of Dr. Marc Suárez-Calvet in The Pasqual Maragall Foundation joined in Barcelona. the research is carried out, as well as the rest UPF: “Is there healthy aging?”, the European Night of the 2018 the initiative “From Bubble - Barcelona of the spaces from which they work tirelessly in By Dr. Jordi Camí and Dr. Nina April 10th. Talk by Cristina Researchers, in Barcelona. for Alzheimer’s”, an awareness project about the prevention and dissemination for a future Maragall on Alzheimer’s and Awards and Gramunt. October 9th. the disease articulated through the work of without Alzheimer’s. the work of the Foundation, Inaugural lesson distinctions contemporary art From Bubble, by the artist February 8th. Participation of as part of the program of the academic year 2018- 2019 of the Pompeu Fabra Recognition of the best work Daniel Bagnon, and that filled the streets of the Dr. Carles Falcon and Sabrina “University Accessible” of the co-financed by FEDER University by Dr. Jordi Camí. city with more than 4,000 bubbles, to symbolize TV3 broadcasts the Life Segundo in the project Martín el Humano University The construction of the new the progressive loss of neuronal connections Soundtrack project within “Interview to a scientist” in the Foundation. October 24th. Participation building of the Pasqual Maragall that Alzheimer’s causes. With its participation in the Sense Ficció program PRBB. Foundation has won the second May 17th. Talk “Prevention of of Dr. Nina Gramunt in the different activities, the Foundation became one prize for the best project On May 8th, the TV3 Sense Ficció program February 17th. Talk about Alzheimer’s, a new scientific “Aging, vulnerability and financed by FEDER in Spain. The of the five entities that integrated the initiative, aired a documentary about the Life Soundtrack Alzheimer’s in the Barcelona FC challenge”, by Dr. Jordi abuse situations” day, at the Pasqual Maragall Foundation in collaboration with the City Council. project with the title “Music is life”. A team of supporters club of Torroella de Camí, in the Pabellón de los University of Barcelona. was the beneficiary of a 2016 Montgrí, by Glòria Mas. FEDER grant managed by the journalists followed for months the different Distinguidos of the Institut November 20th. Talk about Secretariat of Universities and stages of the initiative and collected testimonies Pere Mata in Reus. Open day February 21st. caregivers by Glòria Mas in Research of the Department from students, participants and professionals to Talk “Music and May 24th. Barberà del Vallès with Accent of Economy and Knowledge On December 2nd, the Pasqual Maragall show the revitalizing effect of music on people action against Alzheimer’s”, by Talk about of the Generalitat of Catalonia Dr. Nina Gramunt, at Penyafort- Alzheimer’s by Dr. Nina Social. Foundation and the Barcelonaβeta Brain affected by dementia. for an amount of 2.5 million Montserrat College. Gramunt within the framework November 28th. Participation euros in the framework of the of the Continuous Training of Cristina Maragall as the call to select unique projects of March 1st. Magisterial talk Program of Pharmacy construction of buildings for R & of the 30th anniversary of El main guest at the Mirada D infrastructures. Assistants. Plural breakfast, held in Madrid Saliente, in Almeria. Solidarity Insurance Awards May 25th. Participation of and organized by the agency In the 18th edition of the Social networks in 2018 March 7th. Inaugural lecture Dr. Gonzalo Sánchez in the XI Atrevia. by Dr. Jordi Camí and Dr. Nina Solidarity Insurance Awards Barcelona Biennial Conference, November 30th. Workshop on organized by INESE, MetLife Gramunt of a postgraduate held at CosmoCaixa. Alzheimer’s, given by Dr. Nina Spain awarded the Pasqual course at the Universitat Gramunt at the International Maragall Foundation with Pompeu Fabra, in Barcelona. June 9th and 10th. one of the solidarity prizes in 5,525 Followers Winter Academy and 42,685 Followers Participation in the Barcelona recognition of its Alfa Study March 10th. Masterclass in Science Festival of Dr. Luis organized by EIT Health and research project for the Facebook Twitter Retweets 5,314 Santander, by Glòria Oliver, as Martínez and Dr. Oriol Grau. the University of Barcelona at prevention of Alzheimer’s. 9,457 Likes part of the STEM Talent Girl CosmoCaixa. June 25th. Talk “The care of the Trifermed Prize 2018 2,697 Mentions program. December 11th and 18th. Alzheimer’s patient caregiver, Talks Trifermed, a consulting 27,845 Likes company specializing in March 12th. Participation of the hidden sick”, by Glòria Mas, by Glòria Mas on Alzheimer’s prevention and awareness in business development for Dr. Nina Gramunt in the Brain in Mataró. pharmaceutical companies, Comments the Espai Gironès Shopping 950 Followers Week. biotechnology and entities in 523 September 5th. Participation Center on the occasion of the the biomedical sector, awarded March 22nd. Workshop about YouTube of Cristina Maragall and Dr. campaign “Message to space. the Trifermed 2018 prize in the 9,382 Shares 46,351 Views the overload of the caregiver Nina Gramunt in the 40th For a future that everyone category of foundations to the in the framework of the Conference of the Association remembers. “ Pasqual Maragall Foundation.

32 33 Added data of the Pasqual Maragall Foundation and its research Origin and destination center, the Barcelonaβeta Brain research center Provisional closure of 2018. of resources Data submitted to an annual audit of accounts. At the Pasqual Maragall Foundati on we work to achieve a future without Alzheimer’s through biomedical research. To achieve this, we invest most of the resources obtained in research programs and communicati on and disseminati on acti ons to increase social support for our cause. We also allocate part of the resources to att ract new funds to guarantee the long-term sustainability of the ongoing scienti fi c programs.

% 1% 7% % 8 Other income 59 Clinical trials Administration €130,197 Research €701,418 €573,584 program €5,049,601

Income Expenses 2018 % 2018 % 29 % 46 Investment in network 45 Patrons, partners recruitment of partners and donors and donors % Finalist 5 research projects €3,947,151 €2,470,599 Communication, €3,843,400 dissemination and sensitivity €406,533

€8,491,969 Current income €8,500,277 Current expenses €3,947,151 Patrons, partners and donors €5,049,601 Research program €3,843,400 Finalist research projects €406,533 Communication, dissemination and sensitivity €701,418 Clinical trials €2,470,559 Investment in network recruitment of partners and donors €130,197 Other income €573,584 Administration €126,119 Adjustments for capital subsidies * €4,078 Financial income * €76,119 Financial expenses *

€8,622,166 Total revenues €8,576,397 Total expenditures

* Not included in the graphic. * Not included in the graphic. 34 35 Collaborators

Collaborators Sponsorship Board of the Pasqual Maragall Foundation

We welcome the Consorti um of the Free Trade Zone of Barcelona, Moventi a and the Renta Corporación Foundati on, and we highlight the increases in the contributi ons of Barcelona City Council, Allianz and Cementos. Our thanks to all the enti ti es and companies of our Patronage Council for their support and trust. Our most sincere thanks to the network of partners and donors, as well as institutions, companies and professionals who have Strategic Partners supported our research through contributions and collaborations Our thanks also to all the volunteers who devote their time and help us in organizing actions and events

Special Partners Collaborators 2018: companies, organizations and professionals

Agencia OHMM Jordi Évole Centre de salut Mutxamel Centre de salut de Lutxana Ajuntament de Barcelona Kostal Eléctrica, S.A. Centre de salut Santa Pola Centre de salut San Vicente Alejandra Bonet Lluria Lighti ng System Hospital Universitari San Juan Centre de salut Urban Alejandra Conesa Maria Mestre Centre de salut Bombero Etxaniz Ana Torredemer Metlife Barcelona Centre Zaballa APG Spain, S.L. Mónica Alcalá Hospital Basurto Ajuntament de Girona Associació Catalana de Pitch & Putt Movistar Hospital San Eloy Ajuntament de Sant Cugat Atrevia MSC Valencia Ayuntamiento de Esquivias Ajuntament de Sitges Mútua de Granollers Ajuntament de Terrassa Castelló Ballestero Mora, S.L. My Taxi Barberia Shave the sailor CAP Adrià CSI Almassora Neus Raig CAP Borrell Bcn Container Depot Núria Basi CSI Benicàssim Beatriz Gonzalez-Cristóbal Poyo CAP Casanova CSI Castelló Obra Social CGB CAP Compte Borrell Partners Betti na Farreras Olga Lamas Hospital General Blanca Brillas CAP Larrard Hospital La Plana Orange CAP Les Corts Caprabo Hospital Provincial Port de Barcelona CAP Roger de Flor CCIB RBA Libros CAP Sagrada Família Cinesa Diagonal RCD Español CAP Sardenya Elx Clubs DIR RICOH CAP Vallcarca-Sant Gervasi Centre de salut Altabix Coyfer Santi Millán CAP Vila Olímpica Centre de salut El Raval Dinalager Secció Ball Esporti u Centre de Salut Bon Pastor Centre de salut San Fermín Dreamfi t del Port de Barcelona Centro Forum El Consorci Zona Franca Skydive Empuriabrava El Corte Inglés Tarragona Escola Capitol School de Solsona Comunicación Hospital Broggi CAP Horts de Miró Associated companies l’Hospitalet de Llobregat Together + Hospital de Bellvitge Escola Infanti l Patufet CAP Montblanc Toni Puntí Hospital de Viladecans CAP Sant Pere Escola Púbica Canigó Toti Soler Hospital del Mar - Parc de Salut Mar de Sant Just Desvern El Corte Inglés TRAM Hospital General Hospitalet Espai Gironès Hospital Pius de Valls Urbano Gropello Hospital Privat Universitari Sagrat Cor Establiments Viena, S.A. Hospital Universitari de Tarragona Utt opy Hospital Residència Sant Camil Esti barna Sagep Joan XXIII Vodafone Hospital Sant Antoni Abat. Vilanova Euskaltel Hospital Universitari Sant Joan de Reus Worldcoo i la Geltrú Flavia de Hohenlohe RENFE Fundació Invest For Children Yoigo Fundació RBA València Institutional support Ganadería Les Valls, S.A. Members Network Bilbao Centre de salut La Eliana Gemma Humet Nacional Ambulatori Basurto Ciutat de la Justí cia Hotel Yurbban Passage ADIF Ambulatori Deusto Centro de Salud Clínica Quirón Industria Y Desarrollo Gamax, S.L. Ambulatori Doctor Areilza Hospital Arnau de Vilanova Insti tuto Vila Rovira Ambulatori Javier Saenz de Buruaga Hospital de Llíria Javi Sancho Alacant Centre ambulatori Repelega Hospital La Fe Joan Dausà Centre de salut Cabo Huertas Centre Cabieces Hospital Peset

36 37 Boards Boards

Board of the Pasqual Maragall Foundation (Configuration from February 1st, 2019) Board of the Barcelonaβeta Foundation (Configuration from February 1st, 2019)

Pasqual Maragall Honorary President Montserrat Vendrell President

Diana Garrigosa President Jaume Badia. Chairpersons in representation of the Universitat Pompeu Fabra 1st Vice President Santiago de Torres Jordi Camí Joaquim Coello 12nd Vice President Montserrat Vendrell Josep Maria Martorell Arcadi Navarro Chairpersons Núria Basi Francesc Posas Joaquim Boixareu Marcel Prunera Jordi Camí “la Caixa” (Jaume Giró / Àngel Font) Joaquim Coello Marta Grabulosa Secretary Ignasi Costas - RCD Cristina Maragall Vice secretary Alberto Ouro - RCD Guillem Maragall Jordi Mercader Arcadi Navarro Executive Commission of the Barcelonaβeta Foundation Marcel Prunera Gemma Sendra Narcís Serra President Montserrat Vendrell David Vegara Chairpersons Jordi Camí “la Caixa” (Jaume Giró / Àngel Font) Joaquim Coello

Arcadi Navarro Chairpersons representing the Sponsorship Board Antonio Garcia Ferrer. Fundación ACS Marcel Prunera Miquel Molins. Fundació Banc Sabadell “la Caixa” (Jaume Giró / Àngel Font) Secretary Ignasi Costas - RCD Ignasi Costas Vice secretary Alberto Ouro - RCD Secretary - RCD Vice secretary Alberto Ouro - RCD

Executive Commission of the Pasqual Maragall Foundation

President Montserrat Vendrell

Chairpersons Jordi Camí Joaquim Coello Marcel Prunera Arcadi Navarro “la Caixa” (Jaume Giró / Àngel Font)

Secretary Ignasi Costas - RCD Vice secretary Alberto Ouro - RCD

38 39 We work for a better present, we dream of a future without Alzheimer’s

Collaborate Become www.fpmaragall.org a donor FREE 900 545 545 PHONE LINE

You can also make your donation to account number:

IBAN ES89-2100-6887-6702-0004-0635 Thank you!

40 41 “Nowhere it is written that this disease is invincible.”

Pasqual Maragall October 2007

Wellington, 30 08005 Barcelona +34 933 160 990 [email protected] www.fpmaragall.org www.barcelonabeta.org

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