DOCSLIB.ORG

Journal of Bacteriology

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Journal of Bacteriology JOURNAL OF BACTERIOLOGY VOLUME 148 0 NUMBER 3 0 DECEMBER 1981 EDITORIAL BOARD Simon Silver, Editor-in-Chief(1982) Washington University, St. Louis, Mo. Stanley C. Holt, Editor (1982) Elizabeth McFsil, Editor (1985) Robert Rownd, Editor (1985) University ofMassachusetts, Amherst New York University, New York, N. Y. Northwestern Medical School Samuel Kaplan, Editor (1983) Donald P. Nierlich, Editor (1982) Chicago, Ill. University ofIllinois, Urbana University of California, Los Angeles Paul S. Sypherd, Editor (1984) June J. Lascelles, Editor (1984) Allen T. Phillips, Editor (1985) University of California, Irvine University of Cali'ornia, Los Angeles Pennsylvania State University, University Park Mark Achtman (1982) Ann Ganesan (1982) John H. Nordin (1982) James Akagi (1982) J. F. Gardner (1981) Sunil Palchaudhuri (1982) David Apirion (1982) Robert Gennis (1982) Leo Parks (1982) Arthur I. Aronson (1982) Bijan K. Ghosh (1981) Martin Pato (1981) Gad Avigad (1983) David T. Gibson (1981) Olga Pierucci (1981) Stephen D. Barbour (1982) Harry E. GiDleland, Jr. (1982) Patrick J. Piggot (1981) Manfred E. Bayer (1982) Patricia L. GriLione (1982) William S. Rezaikoff (1982) Claire M. Berg (1983) Walter R. Guild (1981) Palmer Rogers (1981) Robert W. Bernlohr (1982) Tadayo Hashimoto (1982) Burton Rosan (1981) Terry J. Beveridge (1982) Gerald L. Hazelbauer (1981) Barry P. Rosen (1983) Dale C. Birdsell (1981) Charles E. Hehmstetter (1982) Harry Rosenberg (1982) Edwin Boatman (1983) Ulf Heinnng (1982) Antoinette Ryter (1982) Winfried Boos (1982) Peter Hirsch (1982) Abigail Salyers (1981) H. D. Braymer (1982) Bruce Holloway (1982) Gene A. Scarborough (1982) Jean Brenchley (1983) Phip Hylemon (1982) June R. Scott (1981) Patrick J. Brennan (1981) Karin Ihler (1981) Jane K. Setlow (1981) Robert P. Burchard (1982) Joseph elburgg (1981) Peter Setbow (1981) 1. D. J. Burdett (1982) Robert J. Kadner (1982) J. A. Shapiro (1982) Richard 0. Burns (1983) Eva R. Kashket (1981) LuciUe Shapiro (1983) Ercole Canale-Parola (1982) Donald L. Keister (1983) Douglas W. Smith (1983) A. M. Chakrabarty (1983) Edward Kellenberger (1982) Issar Smith (1981) Murray S. Cohn (1982) David E. KenneU (1983) Paul F. Smith (1982) John W. Costerton (1983) Jordan Konisky (1981) Dieter G. Soil (1982) Anthony R. Crofts (1982) K. W. Knox (1982) A. L. Sonenshelin (1983) John E. Cronan, Jr. (1983) Thomas G. Lessle (1982) Brian G. Spratt (1982) Lolita Daneo-Moore (1981) Donl R. Lueking (1981) Eric J. Stanbrdge (1981) Daniel V. Der Vartanian (1982) Ben J. J. Lugtenberg (1983) Roger Storck (1981) Walter J. Dobrogosz (1982) Carolyn MacGregor (1981) Stanley Streicher (1983) W. D. Donachie (1982) Manley Mandel (1981) I. W. Sutheriand (1982) W. Ford Doolittle (1982) Barry Marrs (1981) John L. Swanson (1981) J. Allan Downie (1982) Ann Matthysse (1982) Robert L. Switzer (1982) Gerhart Drews (1982) Neil H. Mendelson (1981) F. Robert Tabita (1981) Charles Earhart (1981) Saly Ann Meyer (I198 1) Kenneth N. Timmis (1981) A. Eisenstark (1982) Robert V. Miller (1981) Alexander Tomasz (1983) David P. Fan (1981) David Mount (1982) James L. Van Etten (1982) Walton L. Fangman (1981) R. G. E. Murray (1983) James A. Wechsler (1981) John D. Foulds (1982) Walter G. Niehaus, Jr. (1981) Henry C. Wu (1981) Hiroshi Nitddo (1981) Howard Zalkin (1982) Walter G. Peter 111, Managing Editor Giselas Pollock, Assistant Managing Editor Linda M. Illig, Production Editor 1913 I St., NW, Washington, DC 20006 EX OFFICIO Frederick C. Neidhardt, President (1981-1982) John C. Sherris, President-Elect (1981-1982) J. Mehsen Joseph, Secretary Brinton M. Miller, Treasurer The Journal of Bacteriology (ISSN 0021-9193), a publication Second class postage paid at Washington, DC 20006, and at of the American Society for Microbiology, 1913 I St., NW, additional mailing offices. Washington, DC 20006, is devoted to the advancement and Made in the United States of America. dissemination of fundamental knowledge concerning bacteria Copyright i) 1981, American Society for Microbiology. and other microorganisms. Instructions to Authors are published All Rights Reserved. in the January issue each year; reprints are available from the Editors and the Publications Office. The Journal is published monthly, and the twelve numbers are divided into four volumes The code at the top ofthe first page of an article in thisjournal per year. The nonmember subscription price is $140 per year. indicates the copyright owner's consent that copies of the article Single copies are $14. The member subscription price is $30 per may be made for personal use, or for personal use of specific year. Correspondence relating to subscriptions, reprints, defective clients. This consent is given on the condition, however, that the copies, availability of back issues, lost or late proofs, disposition copier pay the stated per-copy fee through the Copyright Clear- of submitted manuscripts, and general editorial matters should ance Center, Inc., P.O. Box 765, Schenectady, New York 12301, be directed to the ASM Publications Office, 1913 I St., NW, for copying beyond that permitted by Sections 107 and 108 of Washington, DC 20006 (area 202 833-9680). the U.S. Copyright Law This consent does not extend to other 1' kinds of copying, such as copying for general distribution, for a* idi M 1-t9$ ' 11 f% ( I advertising or promotional purposes, for creating new collective works. or for resale. Author Index AB, Geert, 782 Hall, Carol V., 941 Reeves, Michael W., 861 Ahmad, Fazal, 933 Hedstrom, Richard C., 995 Rock, Charles O., 926 Ahmad, Patricia M., 933 Hegeman, G. D., 904, 991 Rosenthal, R., 1012 Allen, Peter Z., 796 Hofnung, Maurice, 845, 853 Sakaguchi, Kenji, 988 Barth, Peter T., 769 Iino, Tetsuo, 973 Setlow, Jane K., 804, 812 Bennett, P., 788 Ishimoto, Makoto, 762 Shah, Vinod K., 884 Braun-Breton, Catherine, 845, Shockley, Robert K., 995 853 Jackowski, Suzanne, 926 Simon, Melvin, 829 Brewster, James M., 897 Jacques, Nicholas A., 912 Stark, Avishay A., 956, 966 Brill, Winston J., 884 Stein, Daniel C., 796 Brunton, J., 788 Stirling, Lynne A., 933 Kaji, Akira, 983 Strominger, Jack L., 950 Keith, Duane E., Jr., 869 Sutton, Ann, 998 Carr, Noel G., 980 Kane, James F., 1002 Suzuki, Takahito, 973 Clayton, Nancy-Lee, 804, 812 Kim, Y. M., 904, 991 Szekely, Elizabeth, 829 Connelly, Mark C., 796 Konisky, J., 817 Tager, Morris, 861 Danchin, Antoine, 753 Lanka, Erich, 769 Takagi, Michiko, 762 Drummond, Margaret C., 861 Lepouce, Elisabeth, 853 Terrance, Kevin, 889 Liao, Hans H., 919 Thorner, Jeremy, 919 Eagon, Robert G., 995 Lindgren, David M., 950 Tsuchiya, Tomofusa, 762 Lipke, Peter N., 889 Lipsky, R. H., 1012 Ullmann, Agnes, 753 Falkow, Stanley, 877 Longmire, Maria E., 869 Filer, David, 1006 Fischer, Randy S., 1002 van Vliet, Adri J., 782 Prancis, Marilyn, 998 McCarthy, David. 804, 812 Vold, Barbara S., 869 Freundlich, Martin, 998 Morgan, Edward' A., 897 Furano, Anthony V., 1006 Morse, Stephen A., 796 Wakim, Jubran, 1002 Waxman, David J., 950 G6mez-Eichelmann, M. Carmen, Newman, Thomas, 998 Weaver, Craig A., 817 745 Niwa, Osami, 988 Wittenberger, Charles L., 912 Gordon, Joyce K., 884 Notani, Nihal K., 804, 812 Goulbourne, Eric A., Jr., 837 Yamamoto, Tatsumo, 983 Greenberg, E. P., 837 Oostra, Ben A., 782 Yankofsky, Saul A., 956, 966 Grinsted, J., 788 Yanofsky, Charles, 941 Gruber, Max, 782 Yokota, Takeshi, 983 Guidi-Rontani, Chantal, 753 Portnoy, Daniel A., 877 Young, Frank E., 796 Gunge, Norio, 988 Gupta, Manju, 980 Redborg, A. Heger, 817 Zahler, S. A., 1012 ACKNOWLEDGMENT The following have served as invited special reviewers for the Journal during 1981, and their help is greatly appreciated. Bruce Adams Thomas M. Buchanan Bruce Duncan James N. Adams Kenneth Budd Martin Dworkin Sankar Adhya Lee A. Bulla, Jr. R. G. Eagon Julius Adler Ward Bullock Helen Eberle D. G. Ahearn Vickers Burdett Gerald Edelman Henry C. Aldrich Richard Burgess Henry L. Ehrlich Giovanna Ferro-Luzzi Ames B. F. Burnham Max E. Eisenberg Richard L. Anderson Howard Bussey Eric Eisenstadt Wilfred N. Arnold B. R. Byers Frederick A. Eiserling H. N. Arst Enrico Cabib Gerald H. Elkan Alan G. Atherly David H. Calhoun William L. Ellefson Daniel E. Atkinson Allan M. Campbell Bert Ely Barbara J. Bachmann Judy Campbell Thomas F. Emery Thomas 0. Baldwin John Carbon Jerald C. Ensign Clinton E. Ballou Malcolm J. Casadaban Wolfgang Epstein Richard Baltz Michael Cashel Michael S. Esposito W. Lane Barksdale B. Wesley Catlin Karl Esser Eugene Barnes Russell Chan Harold J. Evans Wayne M. Barnes Michael Chandler Douglas E. Eveleigh John A. Baross A. K. Chatterjee Stanley Falkow Peter T. Barth J. S. Chen James L. Farmer Joel Baseman Oscar P. Chilson D. S. Feingold Edward Batone Mary Dell Chilton Joseph J. Ferretti Paul Baumann Ian Chopra A. Howard Fieldsteel Simon Baumberg Koong Nah Chung David H. Figurski Edwin A. Beachey A. J. Clark Robert H. Fillingame Diana Beattie Steven Clarke David Finkelstein Jeffrey Becker Don B. Clewell Richard Finkelstein Jonathan R. Beckwith Stanley N. Cohen William R. Finnerty M. P. Belaich J. Cole Philip Fitz-James Robert M. Bell Roger M. Cole Joel Flaks Robert A. Bender Sylvia E. Coleman Seymour Fogel Peter M. Bennett H. Edward Conrad Tim J. Foster Spencer Benson Terrance Cooper Audree Fowler R. Bentley Catherine Costello Maurice Fox Rolf H. Benzinger Donald L. Court Dan G. Fraenkel Douglas E. Berg C. D. Cox S. Freer R. Berk Nicholas Cozzarelli I. Fridovich Harriet Bernheimer William A. Cramer James D. Friesen Richard Bernstein Marjorie Crandall R. C. Fuller Kevin Bertrand Irving P. Crawford Chandler Fulton Mervyn Bibb Jorge Crosa Clement E. Furlong Michael Bjorn James Cutler Jonathan Gallant Francisco Boliver Stanley Dagley John E. Gander Judith S. Bond H. Dailey E. Garcia Peter Borgia Naomi Datta E. Peter Geiduschek Subir K. Bose Gaston 0. Daumy Peter Gemski, Jr. David Botstein Julian Davis Philipp Gerhardt Kenneth F. Bott Rowland Davis William Ghiorse Volkmar Braun Edwin A. Dawes Charles Gilvarg Hans Bremer Fritz K.
Load more

Recommended publications
  • TETRAHYDROBIOPTERIN DEFICIENCY and BRAIN NITRIC OXIDE METABOLISM by Michael Peter Brand
    TETRAHYDROBIOPTERIN DEFICIENCY AND BRAIN NITRIC OXIDE METABOLISM By Michael Peter Brand A thesis submitted as partial fulfilment for the degree of Doctor of Philosophy in the Faculty of Science at the University of London. March 1997 Institute of Neurology Department of Neurochemistry Queen Square London WCIN 3BG ProQuest Number: 10055824 All rights reserved INFORMATION TO ALL USERS The quality of this reproduction is dependent upon the quality of the copy submitted. In the unlikely event that the author did not send a complete manuscript and there are missing pages, these will be noted. Also, if material had to be removed, a note will indicate the deletion. uest. ProQuest 10055824 Published by ProQuest LLC(2016). Copyright of the Dissertation is held by the Author. All rights reserved. This work is protected against unauthorized copying under Title 17, United States Code. Microform Edition © ProQuest LLC. ProQuest LLC 789 East Eisenhower Parkway P.O. Box 1346 Ann Arbor, Ml 48106-1346 Abstract. Tetrahydrobiopterin is an essential cofactor for the aromatic amino acid mono­ oxygenase group of enzymes. Inborn errors of tetrahydrobiopterin metabolism result in hyperphenylalaninaemia and impaired catecholamine and serotonin turnover. Tetrahydrobiopterin is also a cofactor for all known isoforms of nitric oxide synthase (NOS). The effect of tetrahydrobiopterin deficiency on brain nitric oxide metabolism has to date been given little consideration. In this thesis the effect of tetrahydrobiopterin deficiency on brain nitric oxide metabolism has been studied using a mouse model of tetrahydrobiopterin deficiency, the hph-1 mouse. Tetrahydrobiopterin was measured in 10 and 30 day old mice in whole brain and cerebellum.
    [Show full text]
  • Advances in Biotechnology July 10-12, 2017 Dubai, UAE
    Yu-Chen Hu, Adv Biochem Biotehcnol 2017, 02: 05 (Suppl) http://dx.doi.org/10.29011/2574-7258.C1-003 International Conference on Advances in Biotechnology July 10-12, 2017 Dubai, UAE Baculovirus-mediated MIR-214 suppression shifts osteoporotic ASCS differentiation towards osteogenesis and improves osteoporotic bone defects repair Yu-Chen Hu*, Kuei-Chang Li, Mu-Nung Hsu and Mei-Wei Lin National Tsing Hua University, Hsinchu, Taiwan Osteoporotic patients often suffer from bone fracture but its healing is compromised due to impaired osteogenesis potential of bone marrow-derived mesenchymal stem cells (BMSCs). Here we aimed to exploit adipose-derived stem cells from ovariectomized (OVX) rats (OVX-ASCs) for bone healing. We unraveled that OVX-ASCs highly expressed miR-214 and identified 2 miR-214 targets: CTNNB1 (b-catenin) and TAB2. We demonstrated that miR-214 targeting of these two genes blocked the Wnt pathway, led to preferable adipogenesis and attenuated osteogenesis, undermined the osteogenesis of co- cultured OVX-BMSCs, enhanced exosomal miR-214 release and altered cytokine secretion. As a result, OVX-ASCs implantation into OVX rats failed to heal critical-size metaphyseal bone defects. However, using hybrid baculoviruses expressing miR-214 sponges to transduce OVX-ASCs, we successfully suppressed miR-214 levels, activated the Wnt pathway, upregulated osteogenic factors -catenin/Runx2, downregulated adipogenic factors PPAR-g and C/EBP-a, shifted the differentiation propensity towards osteogenic lineage, enhanced the osteogenesis of co-cultured OVX-BMSCs, elevated BMP7/osteoprotegerin secretion and hindered exosomal miR-214/osteopontin release. Consequently, implanting the miR-214 sponge-expressing OVX-ASCs tremendously improved bone healing in OVX rats.
    [Show full text]
  • L–Asparaginase
    International Journal of Pharmacy and Pharmaceutical Sciences ISSN- 0975-1491 Vol 8, Issue 3, 2016 Original Article SCREENING AND PRODUCTION OF ANTICARCINOGENIC ENZYME FROM ESCHERICHIA COLI CTLS20: L–ASPARAGINASE MURUGESAN THANDEESWARANa, RAMASAMY MAHENDRANa, KALARIKKAL GOPIKRISHNAN KIRANa, K. A. AYUB NAWAZa, MUTHUSAMY PALANISWAMYb, ANGAYARKANNI JAYARAMANa* aCancer Therapeutics Lab, Department of Microbial Biotechnology, Bharathiar University, Coimbatore 641046, bDepartment of Microbiology, Karpagam University, Coimbatore 641021 Email: [email protected] Received: 13 Dec 2015 Revised and Accepted: 25 Jan 2016 ABSTRACT Objective: The objective of this study was attempted to screen the production of L-asparaginase from bacteria isolated from soil samples and its enzymatic activity. Methods: Screening of L-asparaginase was performed using phenol red indicator growth medium from which the positive strains were chosen based on the colour change. The enzyme production of L-asparaginase was established by submerged fermentation followed by the molecular detection of the efficient bacterial strains. Results: The enzyme production was undertaken by submerged fermentation with the evaluation of enzymatic activity and protein content. This revealed that the strain Escherichia coli CTLS20 produced a higher yield of L-asparaginase (30.22 IU/mg), 16.91 µg/ml of protein with the specific activity of 1.787 IU/mg when compared with other bacterial strains. The efficient bacterial strains were also confirmed by 16S rRNA sequence as Escherichia coli, Acinetobacter baumnnii, Klebsiella pneumoniae and the phylogenetic tree construction revealed the evolutionary relationship of the bacterial strains. Conclusion: This study indicated that the bacterial strain E. coli CTLS20 had the ability for the higher production of L-asparaginase. This novel higher yielding bacterial asparaginase is highly desirable as better alternatives in cancer therapy.
    [Show full text]
  • 12) United States Patent (10
    US007635572B2 (12) UnitedO States Patent (10) Patent No.: US 7,635,572 B2 Zhou et al. (45) Date of Patent: Dec. 22, 2009 (54) METHODS FOR CONDUCTING ASSAYS FOR 5,506,121 A 4/1996 Skerra et al. ENZYME ACTIVITY ON PROTEIN 5,510,270 A 4/1996 Fodor et al. MICROARRAYS 5,512,492 A 4/1996 Herron et al. 5,516,635 A 5/1996 Ekins et al. (75) Inventors: Fang X. Zhou, New Haven, CT (US); 5,532,128 A 7/1996 Eggers Barry Schweitzer, Cheshire, CT (US) 5,538,897 A 7/1996 Yates, III et al. s s 5,541,070 A 7/1996 Kauvar (73) Assignee: Life Technologies Corporation, .. S.E. al Carlsbad, CA (US) 5,585,069 A 12/1996 Zanzucchi et al. 5,585,639 A 12/1996 Dorsel et al. (*) Notice: Subject to any disclaimer, the term of this 5,593,838 A 1/1997 Zanzucchi et al. patent is extended or adjusted under 35 5,605,662 A 2f1997 Heller et al. U.S.C. 154(b) by 0 days. 5,620,850 A 4/1997 Bamdad et al. 5,624,711 A 4/1997 Sundberg et al. (21) Appl. No.: 10/865,431 5,627,369 A 5/1997 Vestal et al. 5,629,213 A 5/1997 Kornguth et al. (22) Filed: Jun. 9, 2004 (Continued) (65) Prior Publication Data FOREIGN PATENT DOCUMENTS US 2005/O118665 A1 Jun. 2, 2005 EP 596421 10, 1993 EP 0619321 12/1994 (51) Int. Cl. EP O664452 7, 1995 CI2O 1/50 (2006.01) EP O818467 1, 1998 (52) U.S.
    [Show full text]
  • POLSKIE TOWARZYSTWO BIOCHEMICZNE Postępy Biochemii
    POLSKIE TOWARZYSTWO BIOCHEMICZNE Postępy Biochemii http://rcin.org.pl WSKAZÓWKI DLA AUTORÓW Kwartalnik „Postępy Biochemii” publikuje artykuły monograficzne omawiające wąskie tematy, oraz artykuły przeglądowe referujące szersze zagadnienia z biochemii i nauk pokrewnych. Artykuły pierwszego typu winny w sposób syntetyczny omawiać wybrany temat na podstawie możliwie pełnego piśmiennictwa z kilku ostatnich lat, a artykuły drugiego typu na podstawie piśmiennictwa z ostatnich dwu lat. Objętość takich artykułów nie powinna przekraczać 25 stron maszynopisu (nie licząc ilustracji i piśmiennictwa). Kwartalnik publikuje także artykuły typu minireviews, do 10 stron maszynopisu, z dziedziny zainteresowań autora, opracowane na podstawie najnow­ szego piśmiennictwa, wystarczającego dla zilustrowania problemu. Ponadto kwartalnik publikuje krótkie noty, do 5 stron maszynopisu, informujące o nowych, interesujących osiągnięciach biochemii i nauk pokrewnych, oraz noty przybliżające historię badań w zakresie różnych dziedzin biochemii. Przekazanie artykułu do Redakcji jest równoznaczne z oświadczeniem, że nadesłana praca nie była i nie będzie publikowana w innym czasopiśmie, jeżeli zostanie ogłoszona w „Postępach Biochemii”. Autorzy artykułu odpowiadają za prawidłowość i ścisłość podanych informacji. Autorów obowiązuje korekta autorska. Koszty zmian tekstu w korekcie (poza poprawieniem błędów drukarskich) ponoszą autorzy. Artykuły honoruje się według obowiązujących stawek. Autorzy otrzymują bezpłatnie 25 odbitek swego artykułu; zamówienia na dodatkowe odbitki (płatne) należy zgłosić pisemnie odsyłając pracę po korekcie autorskiej. Redakcja prosi autorów o przestrzeganie następujących wskazówek: Forma maszynopisu: maszynopis pracy i wszelkie załączniki należy nadsyłać w dwu egzem­ plarzach. Maszynopis powinien być napisany jednostronnie, z podwójną interlinią, z marginesem ok. 4 cm po lewej i ok. 1 cm po prawej stronie; nie może zawierać więcej niż 60 znaków w jednym wierszu nie więcej niż 30 wierszy na stronie zgodnie z Normą Polską.
    [Show full text]
  • Goble Biochemistry 2
    Subscriber access provided by - Access paid by the | UCSF Library Article Deamination of 6-Aminodeoxyfutalosine in Menaquinone Biosynthesis by Distantly Related Enzymes Alissa Marie Goble, Rafael Toro, Xu Li, Argentina Ornelas, Hao Fan, Subramaniam Eswaramoorthy, Yury V. Patskovsky, Brandan Hillerich, Ronald D. Seidel, Andrej Sali, Brian K. Shoichet, Steven C. Almo, Subramanyam Swaminathan, Martin E. Tanner, and Frank Michael Raushel Biochemistry, Just Accepted Manuscript • DOI: 10.1021/bi400750a • Publication Date (Web): 23 Aug 2013 Downloaded from http://pubs.acs.org on August 28, 2013 Just Accepted “Just Accepted” manuscripts have been peer-reviewed and accepted for publication. They are posted online prior to technical editing, formatting for publication and author proofing. The American Chemical Society provides “Just Accepted” as a free service to the research community to expedite the dissemination of scientific material as soon as possible after acceptance. “Just Accepted” manuscripts appear in full in PDF format accompanied by an HTML abstract. “Just Accepted” manuscripts have been fully peer reviewed, but should not be considered the official version of record. They are accessible to all readers and citable by the Digital Object Identifier (DOI®). “Just Accepted” is an optional service offered to authors. Therefore, the “Just Accepted” Web site may not include all articles that will be published in the journal. After a manuscript is technically edited and formatted, it will be removed from the “Just Accepted” Web site and published as an ASAP article. Note that technical editing may introduce minor changes to the manuscript text and/or graphics which could affect content, and all legal disclaimers and ethical guidelines that apply to the journal pertain.
    [Show full text]
  • (12) Patent Application Publication (10) Pub. No.: US 2012/0266329 A1 Mathur Et Al
    US 2012026.6329A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2012/0266329 A1 Mathur et al. (43) Pub. Date: Oct. 18, 2012 (54) NUCLEICACIDS AND PROTEINS AND CI2N 9/10 (2006.01) METHODS FOR MAKING AND USING THEMI CI2N 9/24 (2006.01) CI2N 9/02 (2006.01) (75) Inventors: Eric J. Mathur, Carlsbad, CA CI2N 9/06 (2006.01) (US); Cathy Chang, San Marcos, CI2P 2L/02 (2006.01) CA (US) CI2O I/04 (2006.01) CI2N 9/96 (2006.01) (73) Assignee: BP Corporation North America CI2N 5/82 (2006.01) Inc., Houston, TX (US) CI2N 15/53 (2006.01) CI2N IS/54 (2006.01) CI2N 15/57 2006.O1 (22) Filed: Feb. 20, 2012 CI2N IS/60 308: Related U.S. Application Data EN f :08: (62) Division of application No. 1 1/817,403, filed on May AOIH 5/00 (2006.01) 7, 2008, now Pat. No. 8,119,385, filed as application AOIH 5/10 (2006.01) No. PCT/US2006/007642 on Mar. 3, 2006. C07K I4/00 (2006.01) CI2N IS/II (2006.01) (60) Provisional application No. 60/658,984, filed on Mar. AOIH I/06 (2006.01) 4, 2005. CI2N 15/63 (2006.01) Publication Classification (52) U.S. Cl. ................... 800/293; 435/320.1; 435/252.3: 435/325; 435/254.11: 435/254.2:435/348; (51) Int. Cl. 435/419; 435/195; 435/196; 435/198: 435/233; CI2N 15/52 (2006.01) 435/201:435/232; 435/208; 435/227; 435/193; CI2N 15/85 (2006.01) 435/200; 435/189: 435/191: 435/69.1; 435/34; CI2N 5/86 (2006.01) 435/188:536/23.2; 435/468; 800/298; 800/320; CI2N 15/867 (2006.01) 800/317.2: 800/317.4: 800/320.3: 800/306; CI2N 5/864 (2006.01) 800/312 800/320.2: 800/317.3; 800/322; CI2N 5/8 (2006.01) 800/320.1; 530/350, 536/23.1: 800/278; 800/294 CI2N I/2 (2006.01) CI2N 5/10 (2006.01) (57) ABSTRACT CI2N L/15 (2006.01) CI2N I/19 (2006.01) The invention provides polypeptides, including enzymes, CI2N 9/14 (2006.01) structural proteins and binding proteins, polynucleotides CI2N 9/16 (2006.01) encoding these polypeptides, and methods of making and CI2N 9/20 (2006.01) using these polynucleotides and polypeptides.
    [Show full text]
  • All Enzymes in BRENDA™ the Comprehensive Enzyme Information System
    All enzymes in BRENDA™ The Comprehensive Enzyme Information System http://www.brenda-enzymes.org/index.php4?page=information/all_enzymes.php4 1.1.1.1 alcohol dehydrogenase 1.1.1.B1 D-arabitol-phosphate dehydrogenase 1.1.1.2 alcohol dehydrogenase (NADP+) 1.1.1.B3 (S)-specific secondary alcohol dehydrogenase 1.1.1.3 homoserine dehydrogenase 1.1.1.B4 (R)-specific secondary alcohol dehydrogenase 1.1.1.4 (R,R)-butanediol dehydrogenase 1.1.1.5 acetoin dehydrogenase 1.1.1.B5 NADP-retinol dehydrogenase 1.1.1.6 glycerol dehydrogenase 1.1.1.7 propanediol-phosphate dehydrogenase 1.1.1.8 glycerol-3-phosphate dehydrogenase (NAD+) 1.1.1.9 D-xylulose reductase 1.1.1.10 L-xylulose reductase 1.1.1.11 D-arabinitol 4-dehydrogenase 1.1.1.12 L-arabinitol 4-dehydrogenase 1.1.1.13 L-arabinitol 2-dehydrogenase 1.1.1.14 L-iditol 2-dehydrogenase 1.1.1.15 D-iditol 2-dehydrogenase 1.1.1.16 galactitol 2-dehydrogenase 1.1.1.17 mannitol-1-phosphate 5-dehydrogenase 1.1.1.18 inositol 2-dehydrogenase 1.1.1.19 glucuronate reductase 1.1.1.20 glucuronolactone reductase 1.1.1.21 aldehyde reductase 1.1.1.22 UDP-glucose 6-dehydrogenase 1.1.1.23 histidinol dehydrogenase 1.1.1.24 quinate dehydrogenase 1.1.1.25 shikimate dehydrogenase 1.1.1.26 glyoxylate reductase 1.1.1.27 L-lactate dehydrogenase 1.1.1.28 D-lactate dehydrogenase 1.1.1.29 glycerate dehydrogenase 1.1.1.30 3-hydroxybutyrate dehydrogenase 1.1.1.31 3-hydroxyisobutyrate dehydrogenase 1.1.1.32 mevaldate reductase 1.1.1.33 mevaldate reductase (NADPH) 1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH) 1.1.1.35 3-hydroxyacyl-CoA
    [Show full text]
  • United States Patent (19) 11 Patent Number: 4,945,049 Hamaya Et Al
    United States Patent (19) 11 Patent Number: 4,945,049 Hamaya et al. (45) Date of Patent: Jul. 31, 1990 (54) METHOD FOR PREPARING MAGNETIC 0187.192 11/1983 Japan ................................... 435/168 POWDER 60-172288 9/1985 Japan. 2055092 3/1987 Japan ................................... 435/168 75) Inventors: Toru Hamaya, 1-D, Daiichiseifuso, 62-171688 7/1987 Japan. 5-5, Minami 1-chome, Meguro-ku, 62-294089 12/1987 Japan. Tokyo 152; Koki Horikoshi, 39-8, 2192870 4/1988 United Kingdom ................ 435/168 Sakuradai 4-chome, Nerima-ku, Primary Examiner-Herbert J. Lilling Tokyo 176, both of Japan Attorney, Agent, or Firm-Oblon, Spivak, McClelland, 73 Assignees: Research Development Corporation; Maier & Neustadt Toru Hamaya; Koki Horikoshi, all of Tokyo, Japan; a part interest 57 ABSTRACT The present invention relates to a method for preparing 21 Appl. No.: 343,263 magnetic powder comprising homogeneous and fine 22 PCT Filed: Aug. 18, 1988 particles using an alkali-producing enzyme. The object of the present invention is to provide a method suitable (86 PCT No.: PCT/JP88/00814 for preparing magnetic powder comprising relatively S371 Date: Apr. 14, 1989 small particles, for instance, fine particles having a par ticle size ranging from 50 to 500 nm. The present inven S 102(e) Date: Apr. 14, 1989 tion relates to a method for preparing at least one mem (87. PCT Pub. No.: WO89/01521 ber selected from the group consisting of iron oxides, iron hydroxides and iron oxyhydroxides which com PCT Pub. Date: Feb. 23, 1989 prises the step of alkalizing a solution containing iron 30 Foreign Application Priority Data ions utilizing an alkali-producing enzyme and a sub Aug.
    [Show full text]
  • 15. Leveraging Structure for Enzyme Function Prediction: Methods
    Review Leveraging structure for enzyme function prediction: methods, opportunities, and challenges 1,2 1,2 Matthew P. Jacobson , Chakrapani Kalyanaraman , 1,2 1,2 Suwen Zhao , and Boxue Tian 1 Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco, CA 94158, USA 2 California Institute for Quantitative Biomedical Research, University of California, San Francisco, CA 94158, USA The rapid growth of the number of protein sequences One fundamental challenge is that there is no univer- that can be inferred from sequenced genomes presents sal criterion sufficient to determine when a pair of pro- challenges for function assignment, because only a teins are likely to have the same or different functions; small fraction (currently <1%) has been experimentally even if two proteins are highly homologous to one another characterized. Bioinformatics tools are commonly used and have similar structures, a change of only a few to predict functions of uncharacterized proteins. Recent- residues in the active site can change the functional ly, there has been significant progress in using protein specificity [5]. A second fundamental challenge is that structures as an additional source of information to infer annotation transfer, by definition, cannot identify new, aspects of enzyme function, which is the focus of this uncharacterized protein functions. These challenges review. Successful application of these approaches has have motivated the development of diverse approaches led to the identification of novel metabolites, enzyme to protein functional characterization and prediction. activities, and biochemical pathways. We discuss oppor- Such approaches use additional types of information tunities to elucidate systematically protein domains of beyond protein sequence, such as high-throughput meta- unknown function, orphan enzyme activities, dead-end bolomics [6], RNA profiling [7–9], proteomics [10,11], and metabolites, and pathways in secondary metabolism.
    [Show full text]
  • (12) Patent Application Publication (10) Pub. No.: US 2015/0240226A1 Mathur Et Al
    US 20150240226A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2015/0240226A1 Mathur et al. (43) Pub. Date: Aug. 27, 2015 (54) NUCLEICACIDS AND PROTEINS AND CI2N 9/16 (2006.01) METHODS FOR MAKING AND USING THEMI CI2N 9/02 (2006.01) CI2N 9/78 (2006.01) (71) Applicant: BP Corporation North America Inc., CI2N 9/12 (2006.01) Naperville, IL (US) CI2N 9/24 (2006.01) CI2O 1/02 (2006.01) (72) Inventors: Eric J. Mathur, San Diego, CA (US); CI2N 9/42 (2006.01) Cathy Chang, San Marcos, CA (US) (52) U.S. Cl. CPC. CI2N 9/88 (2013.01); C12O 1/02 (2013.01); (21) Appl. No.: 14/630,006 CI2O I/04 (2013.01): CI2N 9/80 (2013.01); CI2N 9/241.1 (2013.01); C12N 9/0065 (22) Filed: Feb. 24, 2015 (2013.01); C12N 9/2437 (2013.01); C12N 9/14 Related U.S. Application Data (2013.01); C12N 9/16 (2013.01); C12N 9/0061 (2013.01); C12N 9/78 (2013.01); C12N 9/0071 (62) Division of application No. 13/400,365, filed on Feb. (2013.01); C12N 9/1241 (2013.01): CI2N 20, 2012, now Pat. No. 8,962,800, which is a division 9/2482 (2013.01); C07K 2/00 (2013.01); C12Y of application No. 1 1/817,403, filed on May 7, 2008, 305/01004 (2013.01); C12Y 1 1 1/01016 now Pat. No. 8,119,385, filed as application No. PCT/ (2013.01); C12Y302/01004 (2013.01); C12Y US2006/007642 on Mar. 3, 2006.
    [Show full text]
  • Isolation and Screening of Pterin Deaminase Producing Fungi From
    International Journal of Applied Research 2016; 2(6): 342-344 ISSN Print: 2394-7500 ISSN Online: 2394-5869 Isolation and screening of pterin deaminase producing Impact Factor: 5.2 IJAR 2016; 2(6): 342-344 fungi from soil samples www.allresearchjournal.com Received: 16-04-2016 Accepted: 17-05-2016 Vijayarani Nallathambi, Angayarkanni Jayaraman and Nallathambi Vijayarani Nallathambi Govindasamy Department of Microbial, Biotechnology, Bharathiar Abstract University, Coimbatore, Tamil Pterin deaminase is a folate deaminating enzyme has been reported to have antitumour activity against Nadu, India. leukemic cell line and melanoma induced in mice. In the present study, a total of twenty five fungal Angayarkanni Jayaraman cultures were isolated from soil sample collected in and around the city of Coimbatore district. The Department of Microbial, diversity of fungal isolates was found to be higher in the cultivated land soil compared to unattended Biotechnology, Bharathiar barren land and coconut plantation soils. A rapid plate assay method was used for the first time to University, Coimbatore, Tamil screen the pterin deaminase producing fungus using folate as a substrate in modified czapek Dox agar Nadu, India. medium. The strain CLS-6 was selected based on the zone of clearance and pink colouration around the zone with a maximum enzyme activity of 40.2 IU/ml and 36.5 mg/ml of protein for further purification Nallathambi Govindasamy and characterization. Department of Millets, Tamil Nadu Agricultural University, Keywords: Pterin deaminase, Lumazine, Folate, Substrate, Cancer Coimbatore, Tamil Nadu, India 1. Introduction Fighting cancer is considered as one of the most important areas of research in medicine and immunology.
    [Show full text]