1550 Chelators Antidotes and

started first since sodium edetate may cause distributed but is concentrated in the kidney, liver, and Profile mobilisation of stored in symptomatic toxicity. A small intestine. is rapidly metabolised and the suggested regimen is to give dimercaprol intramuscularly in metabolites and dimercaprol-metal chelates are excreted in Ditiocarb sodium is a chelator that has been used in nickel an initial dose of 4 mg/kg, followed at 4-hourly intervals by the urine and bile. Elimination is essentially complete carbonyl poisoning. Disulfiram (p. 2495.3), which is rapidly dimercaprol 3 to 4mg/kg intramuscularly and sodium within 4 hours of a single dose. metabolised to ditiocarb, has been used as an alternative. calcium edetate; the sodium calcium edetate may be given Ditiocarb has also been used in the destruction of cisplatin either intravenously, or intramuscularly at a different site Preparations wastes (see Handling and Disposal. p. 768.2). from the dimercaprol. Treatment may be continued for 2 to ...... 7 days depending on the clinical response; in patients with Proprietary Preparations (details are given in Volume B) lead encephalopathy, combined therapy should be Edetic Acid (BAN, fiNN) Single-ingredient Preparations. Rus.: Zorex (30peKC). continued until the patient is stable. In severe lead Acide. Ed~tiqLie:AcidoedeticoiAcido. etilendiarni!'lotetraa­ poisoning, a minimum of 2 days without treatment should Mulfi·ingredient Preparatio·ns. Ukr.: Zarex (30peKc). cetieo; •• Acido .. Etilefldiafl'\minqtetraac:etico;Acidum. Edeti­ elapse before a second course of therapy with either C1.jm; Edathamil;Edetico; aCido;EdetHniha,ppo;. Edetinsaure; combined dimercaprol and sodium calcium edetate or Pharmacopoeial Preparations sodium calcium edetate alone is considered. BP 2014: Dimercaprol Injection; Edetinsyra; Edeto rOgstis;. EDTA;> Ethyle"ndfamfnetetra­ USP 36: Dimercaprol Injection. azijnzuur;. Ethylendiamintetraessigsaure; .• Etilendiamintetrae­ Administration in children. Dimercaprol has been used in cetsav; Etilen-dfamin-tetraecetsw; .Kwas edetynoyvy; Kyselina children in the treatment of acute poisoning by heavy edetova; Tetracemic Acid; 3geToBaRK"cnota. metals such as arsenic, gold, mercury, antimony, and bis­ 4-Dimethylaminophenol Hydrochloride Ethylenediaminetetra-acetic.ilCid. muth. It can also be used with sodium calcium edetate for ClOH SN,Os=292.2 Oimetarnfel1ot Hydrochloride;4-DlrnetHaminsfenol,. hidro­ ' acute . After the second or third injection of C4S - 60:00-4, cloruro de; 4-DMAP; 4-,[\MMeTYInaMt4Ho(jIeHona dimercaprol. about 30% of children develop a [ever that UN/I ~ 9G34HWRVO. may persist until treatment is stopped. Doses are the rt4APOXnop~A. equivalent per unit body-weight to those used in adults, C8Hll NO,HCI,cc173.6 .