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4-Dimethylaminophenol Hydrochloride__第38版.Pdf 1550 Chelators Antidotes and started first since sodium calcium edetate may cause distributed but is concentrated in the kidney, liver, and Profile mobilisation of stored lead in symptomatic toxicity. A small intestine. Dimercaprol is rapidly metabolised and the suggested regimen is to give dimercaprol intramuscularly in metabolites and dimercaprol-metal chelates are excreted in Ditiocarb sodium is a chelator that has been used in nickel an initial dose of 4 mg/kg, followed at 4-hourly intervals by the urine and bile. Elimination is essentially complete carbonyl poisoning. Disulfiram (p. 2495.3), which is rapidly dimercaprol 3 to 4mg/kg intramuscularly and sodium within 4 hours of a single dose. metabolised to ditiocarb, has been used as an alternative. calcium edetate; the sodium calcium edetate may be given Ditiocarb has also been used in the destruction of cisplatin either intravenously, or intramuscularly at a different site Preparations wastes (see Handling and Disposal. p. 768.2). from the dimercaprol. Treatment may be continued for 2 to .......................... 7 days depending on the clinical response; in patients with Proprietary Preparations (details are given in Volume B) lead encephalopathy, combined therapy should be Edetic Acid (BAN, fiNN) Single-ingredient Preparations. Rus.: Zorex (30peKC). continued until the patient is stable. In severe lead Acide. Ed~tiqLie:AcidoedeticoiAcido. etilendiarni!'lotetraa­ poisoning, a minimum of 2 days without treatment should Mulfi·ingredient Preparatio·ns. Ukr.: Zarex (30peKc). cetieo; •• Acido .. Etilefldiafl'\minqtetraac:etico;Acidum. Edeti­ elapse before a second course of therapy with either C1.jm; Edathamil;Edetico; aCido;EdetHniha,ppo;. Edetinsaure; combined dimercaprol and sodium calcium edetate or Pharmacopoeial Preparations sodium calcium edetate alone is considered. BP 2014: Dimercaprol Injection; Edetinsyra; Edeto rOgstis;. EDTA;> Ethyle"ndfamfnetetra­ USP 36: Dimercaprol Injection. azijnzuur;. Ethylendiamintetraessigsaure; .• Etilendiamintetrae­ Administration in children. Dimercaprol has been used in cetsav; Etilen-dfamin-tetraecetsw; .Kwas edetynoyvy; Kyselina children in the treatment of acute poisoning by heavy edetova; Tetracemic Acid; 3geToBaRK"cnota. metals such as arsenic, gold, mercury, antimony, and bis­ 4-Dimethylaminophenol Hydrochloride Ethylenediaminetetra-acetic.ilCid. muth. It can also be used with sodium calcium edetate for ClOH SN,Os=292.2 Oimetarnfel1ot Hydrochloride;4-DlrnetHaminsfenol,. hidro­ ' acute lead poisoning. After the second or third injection of C4S - 60:00-4, cloruro de; 4-DMAP; 4-,[\MMeTYInaMt4Ho(jIeHona dimercaprol. about 30% of children develop a [ever that UN/I ~ 9G34HWRVO. may persist until treatment is stopped. Doses are the rt4APOXnop~A. equivalent per unit body-weight to those used in adults, C8Hll NO,HCI,cc173.6 .<i ...•.•.. Pharmacopoeios. In Bur. (see p. vii). Also in USNF. see p. 1549.3. In the UK the BNFC states that the use of CAS :...c. ..• ·619-60-3 (4-dimethylami(1oph?noO; Ph. Eur. 8: (Edetic Acid). A white or almost white, dimercaprol in heavy metal poisoning has been super­ dirnethyla('()inoqheriiJl·hydroFhlbride). crystalline powder or colourless crystals. Practically seded by other chela tors. However, the American Hospital ATC -,--V03AB27. insoluble in water and in alcohoL It dissolves in dilute Formulary Service states that infants and children with mer­ ATCVet.~·.QV03A827; solutions of alkali hydroxides. Protect from light. cury poisoning have been treated with an intramuscular UNII-OQOF93G1TR. USNF 31: (Edetic Acid). A white crystalline powder. Very dose of dimercaprol 3 mg/kg, given every 4 hours for the slightly soluble in water; soluble in solutions of alkali first 2 days, then every 6 hours for 1 day, then every 12 hydroxides. hours for a further 7 or 8 days. Profile 4-Dimethylaminophenol hydrochloride is reported to Sodium Edetate Adverse Effects and Treatment oxidise haemoglobin to methaemoglobin and has been Monosodium Edetate; Sodu edetynian; 3gerJT HaTp~R. The most consistent adverse effects produced by dimer­ used with sodium thiosulfate as an alternative to sodium nitrite (p. 1574.3) in the treatment of cyanide poisoning. C4S- 17421-19-3 (monosodiumedet()te). caprol are hypertension and tachycardia. Other adverse Doses of 3 to 4mg/kg have been given intravenously. ATe - SOIXA05. effects include nausea, vomiting, headache, burning ATCVet -QS01XA05. sensation of the lips, mouth, throat, eyes, and penis, References. lachrymation and salivation, tingling of the extremities, a 1. Weger NP. Treatment of cyanide poisoning with 4-dimethylaminophe­ NOTE. The name sodium edetate has been used in the sensation of constriction in the throat and chest, muscle nol (DMAP)-expcrimental and clinical overview. Fundam Appl Toxicol literature for various sodium salts of edetic acid. Do not 1983; 3: 387-96. confuse with sodium calcium edetate (p. 1573.2) or pains and muscle spasm, rhinorrhoea, conjunctivitis, 2. Weger NP. Treatment of cyanide poisoning with 4·dimethylaminophe­ sweating, anxiety, weakness, and abdominal pain. Transient nol (DMAP)-experimental and clinical overview. Middle East J etomidate (p. 1901.1); see also Inappropriate Administra­ reductions in the leucocyte count have also been reported. Anesthesiol1990; 10: 389-412. tion, p. 1551.2. High doses have produced hypertensive encephalopathy with convulsions and coma. Pain may occur at the injection Preparations Disodium Edetate (BAN) .............................. site and sterile abscesses occasionally develop. In children, Dinatrii Edetas; OinatiilEdetaslJihy(:ir;cus;.Dinatrrciedetaias; fever commonly occurs and persists during therapy. Proprietary Preparations (details are given in Volume B) Dinatriumedetaatti; Dinatriumedetat; .. ·Disodium.··Edathamil; Adverse effects are dose-related, relatively frequent, and Single-ingredient Preparations. Ger.: 4-DMAP; Neth.: 4-DMAPt. DisodiumEDTA; Disodium Tetracemate;Pisoduedetynian; usually reversible. It has been suggested that ephedrine sulfate 30 to 60 mg, given orally 30 minutes before each Edetan . ~isod~i' . dihydrat;Edetat~ . di~odique; Edetate injection of dimercaprol, may reduce adverse effects; Disoaium; Edetatodfs6dico;Edetyniafl. disodu; EDT A antihistamines may alleviate some of the symptoms. Diprenorphine Hydrochloride (BANM, rlNNM) dis6dico; . NatrH .. Edetas; Natriumedetat;· Natr}um-edetat; Diprenorfina, hidrodoruro de;Diprenorphine, Chlorhydrate Sodium Versenate. Precautions de; Oiprenorphinhydrochlorid; Dipre/'iorphini Hydrochlor­ DisOdiumdihydrogen· ethylenediaminetetra'acetate dihy­ idum; Hidroclorurode diprenorfina; M-5050; ,[\~npeHop(jIMHa drate. Dimercaprol should be used with care in patients with rV1APoxnoPM!1. CIDHi4N,Nil.,Q8:2HP;"'372.2 hypertension or renal impairment. It should be stopped, or CA5-139'33~3(anhydrousdisodjum continued with extreme caution, if acute renal insufficiency (6R,7R, 14S)-17-Cyclopropylrnethyl-7,8-dihydro-7-(1"hydroxy­ I-methylethyl)-6-o-methyl-5,14-etnanb~J7~norfl'\0rph.i.ne (disodium edetate dihydrate). develops during therapy. Alkalinisation of the urine may ATe "'-'SOI)(AOS; protect the kidney during therapy by stabilising the hydrochlori<;le;. 2-[(,),(SR,6R,7R,14Ma';Cyciopropylm<:thyl- ATe Vet~C!50'/XA05. dimercaprol-metal complex. Dimercaprol should not be 4,S,epoxy+hydroxY-5'rn€thqxy:6; 14'ethanomorphinan-7, used in patients with hepatic impairment unless due to yl]prqpan-2'ol hydrOChloride. UNII~BNW36F6MM (anhYdrousdisQdium· edetate), arsenic poisoning. It should not be used in the treatment of C26H3SN04,HCI=462.0 7FW91 C86/((disodium .edetate. dihydrate}. poisoning due to cadmium, iron, or selenium as the C45 -' 14357'78-9 (diprenorphine); Pharmacopoeios. In Bur. (see p. vii), Int., Jpn, and US. dimercaprol-metal complexes formed are more toxic than hydrochloride). Ph. Eur. 8: (Disodium Edetate). A white or almost white, the metals themselves. Dimercaprol injection is usually ATe .Vet .,,-. QV03AB92. crystalline powder. Soluble in water; practically insoluble in formulated in arachis oil, which should be avoided in those UNII-'- WBSlIEP4SN. alcohol. A 5% solution in water has a pH of 4.0 to 5.5. with peanut allergy. pharmacopoeios. In BP(Vel}. Protect from light. G6PD deficiency. Haemolysis has been reportedl during BP(Vet) 2014: (Diprenorphine Hydrochloride). A white or USP 36: (Edetate Disodium). A white crystalline powder. chelation therapy with dimercaprol and sodium calcium almost white crystalline powder. Sparingly soluble in water; Soluble in water. pH of a 5 % solution in water is between edetate for high blood-lead concentrations in 2 children slightly soluble in alcohol; very slightly soluble in 4.0 and 6.0. with a deficiency of G6PD. chloroform; practically insoluble in ether. A 2% solution 1. Janakiraman N, et al. Hemolysis during BAL chelation therapy for high in water has a pH of 4.5 to 6.0. Protect from light. Trisodium Edetate blood lead levels in two G6PD deficient children. Clin Pediatr (Phila) 1978; 17: 485-7. EdetateTrisodium (U5AN);. Edemo tris6dico. Profile Trisodium.hydrogene)h~lenediaminetetra-acetate .. Pregnancy. Although data are scarce, there are reports of Diprenorphine hydrochloride is an opioid antagonist used CIDHJ3 N,N!l,08=358.2 . the use of dimercaprol for poisoning in the second or third as a radioligand in positron -emission tomography to image CAS. cc-l.50-38-9. trimester of pregnancy, without apparent adverse effects opiate receptors. It is also used in veterinary medicine to AIC'-,.SQ1XAOS. on the
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