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EH&S COVID-19 Chemical Disinfectant Safety Information
COVID-19 CHEMICAL DISINFECTANT SAFETY INFORMATION Updated June 24, 2020 The COVID-19 pandemic has caused an increase in the number of disinfection products used throughout UW departments. This document provides general information about EPA-registered disinfectants, such as potential health hazards and personal protective equipment recommendations, for the commonly used disinfectants at the UW. Chemical Disinfectant Base / Category Products Potential Hazards Controls ● Ethyl alcohol Highly flammable and could form explosive Disposable nitrile gloves Alcohols ● ● vapor/air mixtures. ● Use in well-ventilated areas away from o Clorox 4 in One Disinfecting Spray Ready-to-Use ● May react violently with strong oxidants. ignition sources ● Alcohols may de-fat the skin and cause ● Wear long sleeve shirt and pants ● Isopropyl alcohol dermatitis. ● Closed toe shoes o Isopropyl Alcohol Antiseptic ● Inhalation of concentrated alcohol vapor 75% Topical Solution, MM may cause irritation of the respiratory tract (Ready to Use) and effects on the central nervous system. o Opti-Cide Surface Wipes o Powell PII Disinfectant Wipes o Super Sani Cloth Germicidal Wipe 201 Hall Health Center, Box 354400, Seattle, WA 98195-4400 206.543.7262 ᅵ fax 206.543.3351ᅵ www.ehs.washington.edu ● Formaldehyde Formaldehyde in gas form is extremely Disposable nitrile gloves for Aldehydes ● ● flammable. It forms explosive mixtures with concentrations 10% or less ● Paraformaldehyde air. ● Medium or heavyweight nitrile, neoprene, ● Glutaraldehyde ● It should only be used in well-ventilated natural rubber, or PVC gloves for ● Ortho-phthalaldehyde (OPA) areas. concentrated solutions ● The chemicals are irritating, toxic to humans ● Protective clothing to minimize skin upon contact or inhalation of high contact concentrations. -
Chemicals Used for Chemical Manufacturing Page 1 of 2
Chemicals used for Chemical Manufacturing Page 1 of 2 Acetic Acid (Glacial, 56%) Glycol Ether PMA Acetone Glycol Ether PNB Acrylic Acid Glycol Ether PNP Activated Carbon Glycol Ether TPM Adipic Acid Glycols Aloe Vera Grease Aluminum Stearate Gum Arabic Aluminum Sulfate Heat Transfer Fluids Amino Acid Heptane Ammonium Acetate Hexane Ammonium Bicarbonate Hydrazine Hydrate Ammonium Bifluoride Hydrochloric Acid (Muriatic) Ammonium Chloride Hydrogen Peroxide Ammonium Citrate Hydroquinone Ammonium Hydroxide Hydroxylamine Sulfate Ammonium Laureth Sulfate Ice Melter Ammonium Lauryl Sulfate Imidazole Ammonium Nitrate Isobutyl Acetate Ammonium Persulfate Isobutyl Alcohol Ammonium Silicofluoride Calcium Stearate Dipropylene Glycol Isopropanolamine Ammonium Sulfate Carboxymethylcellulose Disodium Phosphate Isopropyl Acetate Antifoams Caustic Potash D'Limonene Isopropyl Alcohol Antifreeze Caustic Soda (All Grades) Dodecylbenzene Sulfonic Acid Isopropyl Myristate Antimicrobials Caustic Soda (Beads, Prills) (DDBSA) Isopropyl Palmitate Antimony Oxide Cetyl Alcohol Dowfrost Itaconic Acid Aqua Ammonia Cetyl Palmitate Dowfrost HD Jojoba Oil Ascorbic Acid Chlorine, Granular Dowtherm SR-1 Keratin Barium Carbonate Chloroform Dowtherm 4000 Lactic Acid Barium Chloride Chromic Acid EDTA Lanolin Beeswax Citric Acid (Dry and Liquid) EDTA Plus Lauric Acid Bentonite Coal Epsom Salt Lauryl Alcohol Benzaldehyde Cocamide DEA Ethyl Acetate Lecithin Benzoic Acid Copper Nitrate Ethyl Alcohol (Denatured) Lime Benzyl Alcohol Copper Sulfate Ethylene Glycol Linoleic Acid Bicarbonate -
Ammonium Persulfate
SAFETY DATA SHEET Ammonium Persulfate Section 1. Identification GHS product identifier : Ammonium Persulfate Code : 76322 Other means of : ammonium persulphate; Peroxydisulfuric acid, diammonium salt; diammonium identification peroxodisulfate; Diammonium persulfate Supplier/Manufacturer : 3420 Central Expressway, Santa Clara CA 95051 In case of emergency : Chemtrec: 1 800 424 9300 Outside USA & Canada: +1 703 527 3887 Section 2. Hazards identification OSHA/HCS status : This material is considered hazardous by the OSHA Hazard Communication Standard (29 CFR 1910.1200). Classification of the : OXIDIZING SOLIDS - Category 3 substance or mixture ACUTE TOXICITY (oral) - Category 4 SKIN CORROSION/IRRITATION - Category 2 SERIOUS EYE DAMAGE/ EYE IRRITATION - Category 2 RESPIRATORY SENSITIZATION - Category 1 SKIN SENSITIZATION - Category 1 SPECIFIC TARGET ORGAN TOXICITY (SINGLE EXPOSURE) (Respiratory tract irritation) - Category 3 GHS label elements Hazard pictograms : Signal word : Danger Hazard statements : May intensify fire; oxidizer. Harmful if swallowed. Causes serious eye irritation. Causes skin irritation. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic skin reaction. May cause respiratory irritation. Precautionary statements Prevention : Wear protective gloves. Wear eye or face protection. In case of inadequate ventilation wear respiratory protection. Keep away from heat. - No smoking. Keep away from clothing, incompatible materials and combustible materials. Take any precaution to avoid mixing with combustibles and other incompatible materials. Use only outdoors or in a well-ventilated area. Avoid breathing dust. Do not eat, drink or smoke when using this product. Wash hands thoroughly after handling. Contaminated work clothing should not be allowed out of the workplace. Response : IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. -
Acrylamide Polymerization — a Practical Approach
electrophoresis tech note 1156 Acrylamide Polymerization — A Practical Approach Paul Menter, Bio-Rad Laboratories, 2000 Alfred Nobel Drive, Polyacrylamide Gel Polymerization Hercules, CA 94547 USA AcrylamideBis Polyacrylamide Introduction The unparalleled resolution and flexibility possible with CH2 CH + CH2 CH CH2 CH CH2 CH CH2 CH polyacrylamide gel electrophoresis (PAGE) has led to its CO CO CO CO CO widespread use for the separation of proteins and nucleic NH2 NH NH2 NH2 NH acids. Gel porosity can be varied over a wide range to meet CH2 CH2 specific separation requirements. Electrophoresis gels and NH NH NH NH buffers can be chosen to provide separation on the basis of CO 2 2 CO CO C O charge, size, or a combination of charge and size. CH2 CH CH2 CH CH2 CH CH2 CH The key to mastering this powerful technique lies in the polymerization process itself. By understanding the important Purity of Gel-Forming Reagents parameters, and following a few simple guidelines, the novice Acrylamide can become proficient and the experienced user can optimize Gel-forming reagents include the monomers, acrylamide and bis, separations even further. as well as the initiators, usually ammonium persulfate and TEMED or, occasionally, riboflavin and TEMED. On a molar This bulletin takes a practical approach to the preparation of basis, acrylamide is by far the most abundant component in the polyacrylamide gels. Its purpose is to provide the information monomer solution. As a result, acrylamide may be the primary required to achieve reproducible, controllable polymerization. source of interfering contaminants (Dirksen and Chrambach For those users interested only in the “bare essentials,” the 1972). -
(Ph.D.) Environmental Engineering
UNIVERSITY OF CINCINNATI Date: June 15, 2005 I, Georgios Anipsitakis , hereby submit this work as part of the requirements for the degree of: Doctorate of Philosophy (Ph.D.) in: Environmental Engineering It is entitled: Cobalt/Peroxymonosulfate and Related Oxidizing Reagents for Water Treatment This work and its defense approved by: Chair: Dr. Dionysios Dionysiou Dr. Paul Bishop Dr. George Sorial Dr. Souhail Al-Abed COBALT/PEROXYMONOSULFATE AND RELATED OXIDIZING REAGENTS FOR WATER TREATMENT A dissertation submitted to the Division of Research and Advanced Studies of the University of Cincinnati in partial fulfillment of the requirements for the degree of DOCTORATE OF PHILOSOPHY (Ph.D.) in the Department of Civil and Environmental Engineering of the College of Engineering 2005 by Georgios P. Anipsitakis Diploma (B.S./M.S.), Chemical Engineering, Nat. Technical Univ. Athens, 2000 Committee Chair: Dr. Dionysios D. Dionysiou ii Abstract This dissertation explores the fundamentals of a novel advanced oxidation technology, the II cobalt/peroxymonosulfate (Co /KHSO5) reagent, for the treatment of persistent and hazardous II substances in water. Co /KHSO5 is based on the chemistry of the Fenton Reagent and proceeds via the generation of sulfate radicals, which similarly to hydroxyl radicals, readily attack and degrade organic and microbial contamination in water. Very few studies have exploited the reactivity of sulfate radicals for environmental applications. Compared to the extensively investigated hydroxyl radicals, sulfate radicals are not fully understood. Following this approach, the coupling of nine transition metals with hydrogen peroxide (H2O2), potassium peroxymonosulfate (KHSO5) and persulfate (K2S2O8) was also explored. The objective was again the generation of inorganic radicals and the efficient degradation of organic contaminants in water. -
Comparison of Effectiveness Disinfection of 2%
ORIGINAL RESEARCH Journal of Dentomaxillofacial Science (J Dentomaxillofac Sci ) December 2018, Volume 3, Number 3: 169-171 P-ISSN.2503-0817, E-ISSN.2503-0825 Comparison of effectiveness disinfection of 2% Original Research glutaraldehyde and 4.8% chloroxylenol on tooth extraction instruments in the Department of Oral CrossMark http://dx.doi.org/10.15562/jdmfs.v3i2.794 Maxillofacial Surgery, Faculty of Dentistry, University of North Sumatera Month: December Ahyar Riza,* Isnandar, Indra B. Siregar, Bernard Volume No.: 3 Abstract Objective: To compare disinfecting effectiveness of 2% glutaraldehyde while the control group was treated with 4.8% chloroxylenol. Each Issue: 2 and 4.8% chloroxylenol on tooth extraction instruments at the instrument was pre-cleaned using a brush, water and soap for both Department of Oral Surgery, Faculty of Dentistry, University of North groups underwent the disinfection process. Sumatera. Results: The results were statistically analyzed using Mann-Whitney Material and Methods: This was an experimental study with post- Test. The comparison between glutaraldehyde and chloroxylenol First page No.: 147 test only control group design approach. Purposive technique is showed a significant difference to the total bacteria count on applied to collect samples which are lower molar extraction forceps. In instrument after disinfection (p=0.014 < 0.05). this study, sample were divided into 2 groups and each consisting of 18 Conclusion: 2% glutaraldehyde was more effective than 4.8% P-ISSN.2503-0817 instruments. The treatment group was treated with 2% glutaraldehyde chloroxylenol at disinfecting lower molar extraction forceps. Keyword: Disinfection, Glutaraldehyde, Chloroxylenol, Forceps E-ISSN.2503-0825 Cite this Article: Riza A, Siregar IB, Isnandar, Bernard. -
Microchip Design for Chemiluminesence Detection
Double spiral detection channel for on-chip chemiluminescence detection Author Lok, Khoi Seng, Kwok, Yien Chian, Nam-Trung, Nguyen Published 2012 Journal Title Sensors and Actuators B: Chemical DOI https://doi.org/10.1016/j.snb.2012.04.047 Copyright Statement © 2012 Elsevier B.V.. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version. Downloaded from http://hdl.handle.net/10072/50085 Griffith Research Online https://research-repository.griffith.edu.au Lab on a Chip for Chemiluminescence Detection Khoi Seng Lok1, Yien Chian Kwok1* and Nam Trung Nguyen2 1National Institute of Education, Nanyang Technological University, Nanyang Walk, Singapore 637616, Singapore. E-mail: [email protected] 2School of Mechanical and Production Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore. E-mail: [email protected] Abstracts In this paper reports a three layered device that consists of a double spiral channel design for chemiluminsence (CL) detection and a passive micromixer to facilitate mixing of reagents. Compared to the design with a single spiral channel, the design with two overlapping spiral channels doubled the CL intensity emitted from the reaction. Furthermore, the addition of the passive micromixer improved the signal by 1.5 times. Luminol-based chemiluminescence reaction was used for the characterization of the device. This device was successfully used for the determination of L-cysteine and uric acid. Keywords: chemiluminescence, lab-on-chip, micro total analysis system, luminol, cobalt, L-cysteine, uric acid 1 Introduction Chemiluminescence (CL) detection methods do not require an excitation light source. -
(12) Patent Application Publication (10) Pub. No.: US 2014/0004156A1 Mellstedt Et Al
US 2014.0004156A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2014/0004156A1 Mellstedt et al. (43) Pub. Date: Jan. 2, 2014 (54) BOLOGICAL INHIBITORS OF ROR1 Publication Classification CAPABLE OF INDUCING CELL, DEATH (51) Int. C. (76) Inventors: Hakan Mellstedt, Stockholm (SE): C07K 6/28 (2006.01) Hodjattallah Rabbani, Stockholm (SE); CI2N IS/II3 (2006.01) Ingrid Teige, Lund (SE) (52) U.S. C. CPC ............ C07K 16/28 (2013.01); CI2N 15/1138 (21) Appl. No.: 13/516,925 (2013.01) USPC ...... 424/400; 530/387.9; 536/24.5:536/23.1; (22) PCT Filed: Dec. 10, 2010 435/320.1; 435/325; 435/375; 424/139.1; (86). PCT No.: PCT/EP2010/007524 514/44. A:536/23.53; 435/331 S371 (c)(1), (57) ABSTRACT (2), (4) Date: Mar. 1, 2013 The invention relates to antibodies and siRNA molecules for (30) Foreign Application Priority Data inducing cell death by the specific binding of ROR1, domains thereof of nucleotide molecules encoding ROR1. There are Dec. 18, 2009 (GB) ................................... O922143.3 also provided methods involving and uses of the antibodies Jun. 3, 2010 (GB) ................................... 1OO93O7.8 and siRNA molecules of the invention. Patent Application Publication Jan. 2, 2014 Sheet 1 of 25 US 2014/0004156A1 L/S.*L/SdXL|-WLIXCRIO6] N Patent Application Publication Jan. 2, 2014 Sheet 2 of 25 US 2014/0004156A1 a bi-saw exit-8 ext: xx x: i. s: s x 8. : xxx xx . ex* x8. gri syst {{..} : twic s yxi-xxii. 33. 8 M. : : ised-east x 8. Patent Application Publication Jan. -
Ac. H' UY1 : T 'I 7 April23,2004
F'll'J 'J.'t/032.770 i!,P,P, it> 0~ -'II-~ I ;J..¾,5 Aece; 11(:c/. WDNR., O'f/?.1 I01i Ac. h' UY1 : t 'I 7 April23,2004 Ms. Pam Mylotta Wisconsin Department of Natural Resources 2300 North Martin Luther King Jr. Street P.O. Box 12436 Milwaukee, Wisconsin 53212-0436 Re: Request for Source Area Chemical Injection Permit C & D Technologies, Inc. 900 Keefe A venue Milwaukee, Wisconsin 53212-1709 Dear Ms. Mylotta: On behalf of the Johnson Controls Battery Group, Inc. (JCBGI) and C & D Technologies, Inc. (C&D), MWH Americas, Inc. (MWH) has prepared this request for an injection permit for groundwater treatment in the acid unloading area at the above referenced site. The purpose of the permit request is to provide information to the Wisconsin Department of Natural Resources (WDNR) for approval to conduct a pilot study and full-scale injection of sodium persulfate into the acid unloading area for treatment of volatile organic compounds (VOCs) in groundwater. BACKGROUND INFORMATION Soil and groundwater contamination were found to exist on the Facility property exceeding State environmental standards, based on the August 1999 Phase II Environmental Site Assessment (ESA) of the Facility. In May and June 2001, remedial action was completed for the on-site lead, PCB, and VOC impacted soils. A summary of the remedial activities is contained in the February 2002 On Site Remedial Actions Construction Completion Report. Approximately 400 tons of VOC impacted soil was removed during this investigation. Temporary wells were installed in July 2001 and November 2001 as part of the groundwater VOC characterization investigations documented in the June 2001 and October 2001 Work Plans, respectively. -
Chemical Analyses for Selected Minor Elements in Pierre Shale
Chemical Analyses for Selected Minor Elements in Pierre Shale GEOLOGICAL SURVEY PROFESSIONAL PAPER 391-A Chemical Analyses for Selected Minor Elements in Pierre Shale By L. F. RADER and F. S. GRIMALDI ANALYTICAL METHODS IN GEOCHEMICAL INVESTIGATIONS OF THE PIERRE SHALE GEOLOGICAL SURVEY PROFESSIONAL PAPER 391-A UNITED STATES GOVERNMENT PRINTING OFFICE, WASHINGTON : 1961 UNITED STATES DEPARTMENT OF THE INTERIOR STEW ART L. UDALL, Secretary GEOLOGICAL SURVEY Thomas B. Nolan, Director For sale by the Superintendent of Documents, U.S. Government Printing Office Washington 25, D.C. CONTENTS Page Page Abstract--_________________________________________ A-l Methods for the determination of individual Introduction ___-----_-_--_________________-__--__-_ 1 constituents Continued General remarks._________________________ ______ 1 Copper lead, and zinc Continued Laboratories. -._---____-_-______________________ 2 Zinc, dithizone method._____^_______________ A-20 Acknowledgments. ___-_-_-_--______--_-_________ 2 Lead, dithizone method______------_-____-__- 22 Division of work________________________________ 2 Arsenic.___________,__________-_-_--___-__---_- 23 Methods selected and treatment of data ___________ 3 Acid digestion, heteropoly blue method________ 23 Sample preparation _________________________________ 4 Alternative fusion-heteropoly blue method_____ 24 Methods for the determination of individual constituents. 4 Titanium. _____________________________________ 4 Selenium, distillation, visual-estimation method.____ 25 Peroxide method._--_--_-____._____________ 4 Molybdenum and tungsten______-____------_---_- 27 Alternative tiron method, ___________________ 5 Isolation by method 1, alpha-benzoinoxime pre Vanadium. _--.---_____-_-___.__________________ 7 cipitation. ___----_-_-_-__--_----_-----_-- 27 Fusion-leach separation method. _____________ 7 Isolation by alternative method 2, alpha-ben Alternative cupferron separation method...... -
Chemical Disinfectants | Disinfection & Sterilization Guidelines | Guidelines Library | Infection Control | CDC 3/19/20, 14:52
Chemical Disinfectants | Disinfection & Sterilization Guidelines | Guidelines Library | Infection Control | CDC 3/19/20, 14:52 Infection Control Chemical Disinfectants Guideline for Disinfection and Sterilization in Healthcare Facilities (2008) Alcohol Overview. In the healthcare setting, “alcohol” refers to two water-soluble chemical compounds—ethyl alcohol and isopropyl alcohol —that have generally underrated germicidal characteristics 482. FDA has not cleared any liquid chemical sterilant or high- level disinfectant with alcohol as the main active ingredient. These alcohols are rapidly bactericidal rather than bacteriostatic against vegetative forms of bacteria; they also are tuberculocidal, fungicidal, and virucidal but do not destroy bacterial spores. Their cidal activity drops sharply when diluted below 50% concentration, and the optimum bactericidal concentration is 60%–90% solutions in water (volume/volume) 483, 484. Mode of Action. The most feasible explanation for the antimicrobial action of alcohol is denaturation of proteins. This mechanism is supported by the observation that absolute ethyl alcohol, a dehydrating agent, is less bactericidal than mixtures of alcohol and water because proteins are denatured more quickly in the presence of water 484, 485. Protein denaturation also is consistent with observations that alcohol destroys the dehydrogenases of Escherichia coli 486, and that ethyl alcohol increases the lag phase of Enterobacter aerogenes 487 and that the lag phase e!ect could be reversed by adding certain amino acids. The bacteriostatic action was believed caused by inhibition of the production of metabolites essential for rapid cell division. Microbicidal Activity. Methyl alcohol (methanol) has the weakest bactericidal action of the alcohols and thus seldom is used in healthcare 488. The bactericidal activity of various concentrations of ethyl alcohol (ethanol) was examined against a variety of microorganisms in exposure periods ranging from 10 seconds to 1 hour 483. -
ABTS/PP Decolorization Assay of Antioxidant Capacity Reaction Pathways
International Journal of Molecular Sciences Review ABTS/PP Decolorization Assay of Antioxidant Capacity Reaction Pathways Igor R. Ilyasov *, Vladimir L. Beloborodov, Irina A. Selivanova and Roman P. Terekhov Department of Chemistry, Sechenov First Moscow State Medical University, Trubetskaya Str. 8/2, 119991 Moscow, Russia; [email protected] (V.L.B.); [email protected] (I.A.S.); [email protected] (R.P.T.) * Correspondence: [email protected]; Tel.: +7-985-764-0744 Received: 30 November 2019; Accepted: 5 February 2020; Published: 8 February 2020 + Abstract: The 2,20-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS• ) radical cation-based assays are among the most abundant antioxidant capacity assays, together with the 2,2-diphenyl-1- picrylhydrazyl (DPPH) radical-based assays according to the Scopus citation rates. The main objective of this review was to elucidate the reaction pathways that underlie the ABTS/potassium persulfate decolorization assay of antioxidant capacity. Comparative analysis of the literature data showed that there are two principal reaction pathways. Some antioxidants, at least of phenolic nature, + can form coupling adducts with ABTS• , whereas others can undergo oxidation without coupling, thus the coupling is a specific reaction for certain antioxidants. These coupling adducts can undergo further oxidative degradation, leading to hydrazindyilidene-like and/or imine-like adducts with 3-ethyl-2-oxo-1,3-benzothiazoline-6-sulfonate and 3-ethyl-2-imino-1,3-benzothiazoline-6-sulfonate as marker compounds, respectively. The extent to which the coupling reaction contributes to the total antioxidant capacity, as well as the specificity and relevance of oxidation products, requires further in-depth elucidation.