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EH&S COVID-19 Chemical Disinfectant Safety Information
COVID-19 CHEMICAL DISINFECTANT SAFETY INFORMATION Updated June 24, 2020 The COVID-19 pandemic has caused an increase in the number of disinfection products used throughout UW departments. This document provides general information about EPA-registered disinfectants, such as potential health hazards and personal protective equipment recommendations, for the commonly used disinfectants at the UW. Chemical Disinfectant Base / Category Products Potential Hazards Controls ● Ethyl alcohol Highly flammable and could form explosive Disposable nitrile gloves Alcohols ● ● vapor/air mixtures. ● Use in well-ventilated areas away from o Clorox 4 in One Disinfecting Spray Ready-to-Use ● May react violently with strong oxidants. ignition sources ● Alcohols may de-fat the skin and cause ● Wear long sleeve shirt and pants ● Isopropyl alcohol dermatitis. ● Closed toe shoes o Isopropyl Alcohol Antiseptic ● Inhalation of concentrated alcohol vapor 75% Topical Solution, MM may cause irritation of the respiratory tract (Ready to Use) and effects on the central nervous system. o Opti-Cide Surface Wipes o Powell PII Disinfectant Wipes o Super Sani Cloth Germicidal Wipe 201 Hall Health Center, Box 354400, Seattle, WA 98195-4400 206.543.7262 ᅵ fax 206.543.3351ᅵ www.ehs.washington.edu ● Formaldehyde Formaldehyde in gas form is extremely Disposable nitrile gloves for Aldehydes ● ● flammable. It forms explosive mixtures with concentrations 10% or less ● Paraformaldehyde air. ● Medium or heavyweight nitrile, neoprene, ● Glutaraldehyde ● It should only be used in well-ventilated natural rubber, or PVC gloves for ● Ortho-phthalaldehyde (OPA) areas. concentrated solutions ● The chemicals are irritating, toxic to humans ● Protective clothing to minimize skin upon contact or inhalation of high contact concentrations. -
Comparative Analysis of Chlorhexidine Gluconate, Povidone Iodine and Chloroxylenol As Scrubbing Solution
British Journal of Pharmacology and Toxicology 1(2): 93-95, 2010 ISSN: 2044-2467 © Maxwell Scientific Organization, 2010 Submitted date: May 20, 2010 Accepted date: August 21, 2010 Published date: November 15, 2010 Comparative Analysis of Chlorhexidine Gluconate, Povidone Iodine and Chloroxylenol as Scrubbing Solution 1A.S. Yakubu, 1A.A. Abubakar, 2M.D. Salihu, 1A. Jibril and 1I. Isah 1Department of Veterinary Medicine, Surgery and Theriogenology 2Department of Veterinary Public Health and Preventive Medicine, Usmanu Danfodiyo University, Sokoto Abstract: The study was carried out to determine the efficacy of stock concentration of the commonly used disinfectant as scrub solution for surgical site in goats. The evaluation of efficacy and safety of commercially available disinfectant and antiseptic (0.3% Chlorhexidine gluconate, 0.4% Chloroxylenol and 4% Povidone iodine) as scrub solution for surgical site, using stock concentration was assessed in thirty (30) Red Sokoto goats undergoing non elective surgical procedures at Usmanu Danfodiyo University, Veterinary Teaching Hospital and Zonal Veterinary Clinic, Sokoto. Colony counting was used to quantify skin bacteria Colony Forming Unit (CFU) at surgical site before and after skin preparation. Reduction of CFU before and after preparation was significant with all the three disinfectants compared (p<0.05) and the result shows that Povidone iodine and Chloroxylenol to be less effecacious than Chlorhexidine gluconate when mean colony forming unit after two minute of preparing the surgical sites. -
(12) Patent Application Publication (10) Pub. No.: US 2014/0004156A1 Mellstedt Et Al
US 2014.0004156A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2014/0004156A1 Mellstedt et al. (43) Pub. Date: Jan. 2, 2014 (54) BOLOGICAL INHIBITORS OF ROR1 Publication Classification CAPABLE OF INDUCING CELL, DEATH (51) Int. C. (76) Inventors: Hakan Mellstedt, Stockholm (SE): C07K 6/28 (2006.01) Hodjattallah Rabbani, Stockholm (SE); CI2N IS/II3 (2006.01) Ingrid Teige, Lund (SE) (52) U.S. C. CPC ............ C07K 16/28 (2013.01); CI2N 15/1138 (21) Appl. No.: 13/516,925 (2013.01) USPC ...... 424/400; 530/387.9; 536/24.5:536/23.1; (22) PCT Filed: Dec. 10, 2010 435/320.1; 435/325; 435/375; 424/139.1; (86). PCT No.: PCT/EP2010/007524 514/44. A:536/23.53; 435/331 S371 (c)(1), (57) ABSTRACT (2), (4) Date: Mar. 1, 2013 The invention relates to antibodies and siRNA molecules for (30) Foreign Application Priority Data inducing cell death by the specific binding of ROR1, domains thereof of nucleotide molecules encoding ROR1. There are Dec. 18, 2009 (GB) ................................... O922143.3 also provided methods involving and uses of the antibodies Jun. 3, 2010 (GB) ................................... 1OO93O7.8 and siRNA molecules of the invention. Patent Application Publication Jan. 2, 2014 Sheet 1 of 25 US 2014/0004156A1 L/S.*L/SdXL|-WLIXCRIO6] N Patent Application Publication Jan. 2, 2014 Sheet 2 of 25 US 2014/0004156A1 a bi-saw exit-8 ext: xx x: i. s: s x 8. : xxx xx . ex* x8. gri syst {{..} : twic s yxi-xxii. 33. 8 M. : : ised-east x 8. Patent Application Publication Jan. -
Disinfection of Tonometers a Report by the American Academy of Ophthalmology
Ophthalmic Technology Assessment Disinfection of Tonometers A Report by the American Academy of Ophthalmology Anna K. Junk, MD,1 Philip P. Chen, MD,2 Shan C. Lin, MD,3 Kouros Nouri-Mahdavi, MD,4 Sunita Radhakrishnan, MD,5 Kuldev Singh, MD, MPH,6 Teresa C. Chen, MD7 Objective: To examine the efficacy of various disinfection methods for reusable tonometer prisms in eye care and to highlight how disinfectants can damage tonometer tips and cause subsequent patient harm. Methods: Literature searches were conducted last in October 2016 in the PubMed and the Cochrane Library databases for original research investigations. Reviews, non-English language articles, nonophthalmology articles, surveys, and case reports were excluded. Results: The searches initially yielded 64 unique citations. After exclusion criteria were applied, 10 labo- ratory studies remained for this review. Nine of the 10 studies used tonometer prisms and 1 used steel discs. The infectious agents covered in this assessment include adenovirus 8 and 19, herpes simplex virus (HSV) 1 and 2, human immunodeficiency virus 1, hepatitis C virus, enterovirus 70, and variant Creutzfeldt-Jakob disease. All 4 studies of adenovirus 8 concluded that after sodium hypochlorite (dilute bleach) disinfection, the virus was undetectable, but only 2 of the 4 studies found that 70% isopropyl alcohol (e.g., alcohol wipes or soaks) eradicated all viable virus. All 3 HSV studies concluded that both sodium hypochlorite and 70% isopropyl alcohol eliminated HSV. Ethanol, 70% isopropyl alcohol, dilute bleach, and mechanical cleaning all lack the ability to remove cellular debris completely, which is necessary to prevent prion transmission. Therefore, single-use tonometer tips or disposable tonometer covers should be considered when treating patients with suspected prion disease. -
Nomination Background: N-(3-Chloroallyl)Hexaminium Chloride
• NATIONAL TOXICOLOGY PROGRAM EXECUTIVE SUMMARY OF SAFETY AND TOXICITY INFORMATION N-(3-CHLOROALLYL)HEXAMINIUM CHLORIDE CAS Number 4080-31-3 July 16, 1991 Submitted to: NATIONAL TOXICOLOGY PROGRAM Submitted by: Arthur D. Little, Inc. Chemical Evaluation Committee Draft Report • • TABLE OF CONTENTS Page L NOMINATION HISTORY AND REVIEW .................... 1 II. CHEMICAL AND PHYSICAL DATA ....................... 3 III. PRODUCTION/USE ................................... 5 IV. EXPOSURE/REGULATORY STATUS...................... .10 V. TOXICOLOGICAL EFFECTS ........................... .11 VI. STRUCTURE ACTIVITY RELATIONSHIPS ..................48 VII. REFERENCES ..................................... : . ......... 49 APPENDIX I, ON-LINE DATA BASES SEARCHED ............ .53 APPENDIX II, SAFETY INFORMATION.................... .54 1 ,, .• • • OVERVJEWl Nomination History: N-(3-Chloroallyl)hexaminium chloride was originally nominated for carcinogenicity testing by the National Cancer Institute (NCI) in 1980 with moderate priority. In March 1980, the Chemical Evaluation Committee (CEC) recommended carcinogenicity testing. Due to budgetary cutbacks in 1982, this compound was reevaluated and recommended for in vitro cytogenetics and chemical disposition testing by the CEC, and was selected for chemical disposition testing by the Executive Committee. The renomination of this chemical in 1984 by the NCI was based on potentialfor significant human exposure and concern that it may be carcinogenic due to structural considerations. This recent nomination was -
Chemical Disinfectants | Disinfection & Sterilization Guidelines | Guidelines Library | Infection Control | CDC 3/19/20, 14:52
Chemical Disinfectants | Disinfection & Sterilization Guidelines | Guidelines Library | Infection Control | CDC 3/19/20, 14:52 Infection Control Chemical Disinfectants Guideline for Disinfection and Sterilization in Healthcare Facilities (2008) Alcohol Overview. In the healthcare setting, “alcohol” refers to two water-soluble chemical compounds—ethyl alcohol and isopropyl alcohol —that have generally underrated germicidal characteristics 482. FDA has not cleared any liquid chemical sterilant or high- level disinfectant with alcohol as the main active ingredient. These alcohols are rapidly bactericidal rather than bacteriostatic against vegetative forms of bacteria; they also are tuberculocidal, fungicidal, and virucidal but do not destroy bacterial spores. Their cidal activity drops sharply when diluted below 50% concentration, and the optimum bactericidal concentration is 60%–90% solutions in water (volume/volume) 483, 484. Mode of Action. The most feasible explanation for the antimicrobial action of alcohol is denaturation of proteins. This mechanism is supported by the observation that absolute ethyl alcohol, a dehydrating agent, is less bactericidal than mixtures of alcohol and water because proteins are denatured more quickly in the presence of water 484, 485. Protein denaturation also is consistent with observations that alcohol destroys the dehydrogenases of Escherichia coli 486, and that ethyl alcohol increases the lag phase of Enterobacter aerogenes 487 and that the lag phase e!ect could be reversed by adding certain amino acids. The bacteriostatic action was believed caused by inhibition of the production of metabolites essential for rapid cell division. Microbicidal Activity. Methyl alcohol (methanol) has the weakest bactericidal action of the alcohols and thus seldom is used in healthcare 488. The bactericidal activity of various concentrations of ethyl alcohol (ethanol) was examined against a variety of microorganisms in exposure periods ranging from 10 seconds to 1 hour 483. -
Guideline for Disinfection and Sterilization in Healthcare Facilities, 2008
Guideline for Disinfection and Sterilization in Healthcare Facilities, 2008 Guideline for Disinfection and Sterilization in Healthcare Facilities, 2008 William A. Rutala, Ph.D., M.P.H.1,2, David J. Weber, M.D., M.P.H.1,2, and the Healthcare Infection Control Practices Advisory Committee (HICPAC)3 1Hospital Epidemiology University of North Carolina Health Care System Chapel Hill, NC 27514 2Division of Infectious Diseases University of North Carolina School of Medicine Chapel Hill, NC 27599-7030 1 Guideline for Disinfection and Sterilization in Healthcare Facilities, 2008 3HICPAC Members Robert A. Weinstein, MD (Chair) Cook County Hospital Chicago, IL Jane D. Siegel, MD (Co-Chair) University of Texas Southwestern Medical Center Dallas, TX Michele L. Pearson, MD (Executive Secretary) Centers for Disease Control and Prevention Atlanta, GA Raymond Y.W. Chinn, MD Sharp Memorial Hospital San Diego, CA Alfred DeMaria, Jr, MD Massachusetts Department of Public Health Jamaica Plain, MA James T. Lee, MD, PhD University of Minnesota Minneapolis, MN William A. Rutala, PhD, MPH University of North Carolina Health Care System Chapel Hill, NC William E. Scheckler, MD University of Wisconsin Madison, WI Beth H. Stover, RN Kosair Children’s Hospital Louisville, KY Marjorie A. Underwood, RN, BSN CIC Mt. Diablo Medical Center Concord, CA This guideline discusses use of products by healthcare personnel in healthcare settings such as hospitals, ambulatory care and home care; the recommendations are not intended for consumer use of the products discussed. 2 -
FACT SHEET Chemical Disinfectants
FACT SHEET Chemical Disinfectants In the laboratory setting, chemical disinfection is the most common method employed to decontaminate surfaces and disinfect waste liquids. In most laboratories, dilutions of household bleach is the preferred method but there are many alternatives that may be considered and could be more appropriate for some agents or situations. There are numerous commercially available products that have been approved by the Environmental Protection Agency (EPA). EPA Registered Sterilizers, Tuberculocides, and Antimicrobial Products Against Certain Human Public Health Bacteria and Viruses can be found at https://www.epa.gov/pesticide- registration/selected-epa-registered-disinfectants Most EPA-registered disinfectants have a 10-minute label claim. However, OEHS Biosafety recommends a 15-20 minute contact time for disinfection/decontamination. General Considerations Prior to using a chemical disinfectant always consult the manufacturer’s instructions to determine the efficacy of the disinfectant against the biohazards in your lab and be sure to allow for sufficient contact time. In addition, consult the Safety Data Sheet for information regarding hazards, the appropriate protective equipment for handling the disinfectant and disposal of disinfected treated materials. Federal law requires all applicable label instructions on EPA-registered products to be followed (e.g., use-dilution, shelf life, storage, material compatibility, safe use, and disposal). Do not attempt to use a chemical disinfectant for a purpose it was not designed for. • When choosing a disinfectant consider the following: • The microorganisms present • The item to be disinfected or surface(s) • Corrosivity or hazards associated with the chemicals in the disinfectant • Ease of use 1. Organism Sensitivity and Resistant Organisms The innate characteristics of microorganisms often determine its sensitivity to chemical disinfection (Table 1). -
Evaluation of Glutaraldehyde, Chloramine-T, Bronopol, Incimaxx
re Rese tu arc ul h c & a u D Grasteau et al., J Aquac Res Development 2015, 6:12 q e A v f e l o o l p a http://dx.doi.org/10.4172/2155-9546.1000382 m Aquaculture n r e u n o t J ISSN: 2155-9546 Research & Development Research Article Article OpenOpen Access Access Evaluation of Glutaraldehyde, Chloramine-T, Bronopol, Incimaxx Aquatic® and Hydrogen Peroxide as Biocides against Flavobacterium psychrophilum for Sanitization of Rainbow Trout Eyed Eggs Alexandra Grasteau1, Thomas Guiraud1, Patrick Daniel2, Ségolène Calvez3, Valérie Chesneau4 and Michel Le Hénaff1* 1Bordeaux University, CNRS UMR EPOC, Talence, France 2Laboratoire des Pyrénées et des Landes, Mont de Marsan, France 3LUNAM University, Oniris, UMR INRA BioEpAR, Nantes, France 4Groupement de Défense Sanitaire Aquacole d'Aquitaine, Mont de Marsan, France Abstract The effective conditions of glutaraldehyde, chloramine-T, bronopol, Incimaxx Aquatic® and hydrogen peroxide as some biocides commonly used by the aquaculture industry were investigated against F. psychrophilum in sanitization of rainbow trout eyed eggs. Bacteriostatic tests as well as bactericidal tests using ethidium monoazide bromide PCR assays were conducted in vitro on Flavobacterium psychrophilum while impacts of chemical treatments were studied in vivo on 240 [°C × days] rainbow trout eyed eggs. A 20-min contact time with bronopol (up to 2,000 ppm), chloramine-T (up to 1,200 ppm), glutaraldehyde (up to 1,500 ppm), hydrogen peroxide (up to 1,500 ppm) or with Incimaxx Aquatic® (up to 185 ppm, eq. peracetic acid) was effective against F. psychrophilum and did not affect the eyed eggs/fry viability. -
Guideline for Use of High Level Disinfectants & Sterilants For
Guideline for Use of High Level Disinfectants & Sterilants for Reprocessing Flexible Gastrointestinal Endoscopes Guideline for Use of High Level Disinfectants & Sterilants for Reprocessing Flex. Gastrointestinal Endoscopes Acknowledgements Copyright © 2013. Society of Gastroenterology Nurses and Associates, Inc. (SGNA). First published 1998, 2003, 2006, 2007, 2010 & 2013. This document was prepared and written by the SGNA Practice Committee and adopted by the SGNA Board of Directors. It is published as a service to SGNA members. SGNA Practice Committee 2013-14 Michelle R. Juan, MSN, RN, CGRN - Chair Ann Herrin, BSN, RN, CGRN - Co-chair Catherine Concert, DNP, RN, FNP-BC, CGRN Judy Lindsay, MA, BSN, RN, CGRN Midolie Loyola, MSN, RN, CGRN Beja Mlinarich, BSN, RN, CAPA Marilee Schmelzer, PhD, RN Sharon Yorde, BSN, RN, CGRN Kristine Barman, BSN, RN, CGRN Cynthia M. Friis, Med, BSN, RN-BC Reprints are available for purchase from SGNA Headquarters. To order, contact: Department of Membership Services Society of Gastroenterology Nurses and Associates, Inc. 330 North Wabash Chicago, IL 60611-4267 Tel: (800) 245-SGNA or (312) 321-5165 Fax: (312) 673-6694 Online: www.SGNA.org Email: [email protected] Disclaimer The Society of Gastroenterology Nurses and Associates, Inc. (SGNA) presents this guideline for use in developing institutional policies, procedures, and/or protocols. Information contained in this guideline is based on current published data and current practice at the time of publication. The Society of Gastroenterology Nurses and Associates, Inc. assumes no responsibility for the practices or recommendations of any member or other practitioner, or for the policies and practices of any practice setting. Nurses and associates function within the limits of state licensure, state nurse practice act, and/or institutional policy. -
Disinfection and Sterilization
Disinfection and Sterilization William A. Rutala, Ph.D., M.P.H. University of North Carolina (UNC) Health Care System and UNC at Chapel Hill, NC Disinfection and Sterilization z HICPAC Guideline z Provide overview of disinfection and sterilization principles z Emerging pathogens and prions z Current Research Clostridium difficile Ophthalmic equipment (applanation tonometers) Infrared coagulation Microfiber mops Computer keyboards QUAT absorption Failure to follow disinfection/sterilization principles and patient exposures 1 disinfectionandsterilization.org Disinfection and Sterilization in Healthcare Facilities WA Rutala, DJ Weber, and HICPAC, “In press” z Overview Last CDC guideline in 1985 274 pages (>130 pages preamble, 21 pages recommendations, glossary of terms, tables/figures, >1000 references) Evidence-based guideline Cleared by HICPAC February 2003 Reviewed by OMB Publication in December 2006 2 Efficacy of Disinfection/Sterilization Influencing Factors Cleaning of the object Organic and inorganic load present Type and level of microbial contamination Concentration of and exposure time to disinfectant/sterilant Nature of the object Temperature and relative humidity 3 Disinfection and Sterilization EH Spaulding believed that how an object will be disinfected depended on the object’s intended use. CRITICAL - objects which enter normally sterile tissue or the vascular system or through which blood flows should be sterile. SEMICRITICAL - objects that touch mucous membranes or skin that is not intact require a disinfection process (high-level disinfection [HLD]) that kills all microorganisms but high numbers of bacterial spores. NONCRITICAL -objects that touch only intact skin require low-level disinfection. 4 Processing “Critical” Patient Care Objects Classification: Critical objects enter normally sterile tissue or vascular system, or through which blood flows. -
Paul-Ehrlich-Institut Bundesinstitut Für Impfstoffe Und Biomedizinische Arzneimittel Federal Institute for Vaccines and Biomedicines
Paul-Ehrlich-Institut Bundesinstitut für Impfstoffe und biomedizinische Arzneimittel Federal Institute for Vaccines and Biomedicines PAUL-EHRLICH-INSTITUT Paul-Ehrlich-Straße 51-59 D-63225 Langen MUTUAL RECOGNITION PROCEDURE MUMS PRODUCT PUBLICLY AVAILABLE ASSESSMENT REPORT FOR A VETERINARY MEDICINAL PRODUCT CLOSTRIPORC A Clostridium perfringens type A – toxoid vaccine, for pigs (pregnant sows and gilts) 1/14 Clostriporc A DE/V/0262/001/MR IDT Mutual Recognition Procedure Public assessment report ______________________________________________________________________ PRODUCT SUMMARY EU Procedure number DE/V/0262/001/MR Name, strength and Clostriporc A pharmaceutical form Clostridium perfringens type A – toxoid vaccine, for pigs (pregnant sows and gilts) Suspension for injection for subcutaneous use Applicant IDT Biologika GmbH Am Pharmapark 06861 Dessau-Roßlau Germany Active substance(s) One vaccine dose (2 ml) contains: Immunologically active substance Clostridium perfringens type A toxoids: alpha toxoid min. 125 rU*/ ml beta2 toxoid min. 770 rU* /ml * toxoid content in relative units per ml, determined in ELISA against an internal standard Adjuvant Montanide Gel 37.4-51.5 mmol/l titratable acrylate units Excipients Thiomersal 0.2 mg ATC Vetcode QI09AB12 Target species pigs (pregnant sows and gilts) Indication for use For the passive immunisation of piglets by active immunisation of pregnant sows and gilts to reduce clinical signs during the first days of life caused by Clostridium perfringens type A expressing alpha and beta2 toxins. This protection was proven in a challenge test with toxins on sucklers on the first day of life. Serological data show that neutralising antibodies are present up to the 4th week after birth. 2/14 Clostriporc A DE/V/0262/001/MR IDT Mutual Recognition Procedure Public assessment report ______________________________________________________________________ Summary of Product Characteristics 1.