(12) STANDARD PATENT (11) Application No. AU 2012201147 B2 (19) AUSTRALIAN PATENT 0 FFICE

(54) Title Insecticidal mixture containing gamma-cyhalothrin

(51) International Patent Classification(s) A01N 25/30 (2006.01) A01N 47/34(2006.01) A01N 37/28 (2006.01) A01N 47/40 (2006.01) A01N 41/02 (2006.01) A01N 47/42 (2006.01) A01N 43/36 (2006.01) A01N 51/00 (2006.01) A01N 43/40 (2006.01) A01N 53/00 (2006.01) A01N 43/56 (2006.01) A01N 53/08 (2006.01) A01N 43/58 (2006.01) A01N 57/14 (2006.01) A01N 43/653 (2006.01) A01N 57/76 (2006.01) A01N 47/18 (2006.01) A01N 63/02 (2006.01) A01N 47/20 (2006.01)

(21) Application No: 2012201147 (22) Date of Filing: 2012.02.27

(43) Publication Date: 2012.03.22 (43) Publication Journal Date: 2012.03.22 (44) Accepted Journal Date: 2013.09.12

(62) Divisional of: 2011201771

(71) Applicant(s) Syngenta Limited

(72) Inventor(s) Clough, Martin Stephen

(74) Agent / Attorney Phillips Ormonde Fitzpatrick, 367 Collins Street, Melbourne, VIC, 3000

(56) Related Art US 4362722 A 2012201147 27 Feb 2012 5

of controlling cyhalothrin, A «filename*

the mixture

pests

of insect,

with chlorpyrifos

gamma-cyhalothrin

an

acarine

effective

and or

amount

nematode an

insecticidally and

of

chlorpyrifos.

pests a

mixture

ABSTRACT at

inert a

locus comprising

An carrier

which

insecticidal

or

gamma-cyhalothrin comprises

diluents.

composition

A treating

method

the and comprising

of

pests chlorpyrifos.

combatting

or

the gamma-

locus

and

T

♦' .. AUSTRALIA

Patents Act 2012

COMPLETE SPECIFICATION (ORIGINAL) Feb

Class Int. Class 27 Application Number: Lodged:

Complete Specification Lodged: Accepted: Published:

Priority 2012201147

Related Art:

Name of Applicant:

Syngenta Limited

Actual Inventor(s):

Martin Stephen Clough

Address for Service and Correspondence:

PHILLIPS ORMONDE FITZPATRICK Patent and Trade Mark Attorneys 367 Collins Street Melbourne 3000 AUSTRALIA

Invention Title:

INSECTICIDAL MIXTURE CONTAINING GAMMA-CYHALOTHRIN

Our Ref: 936111 POFCode: 459053/207385

The following statement is a full description of this invention, including the best method of performing it known to applicant(s):

-1 -

eOOftq 1a

INSECTICIDAL MIXTURE CONTAINING GAMMA-CYHALOTHRIN 2012

The present application is a divisional application from Australian Patent Application No. 2011201771, which is itself a divisional application from Australian Patent Application No. Feb

5 2008200430, which is itself a divisional application from Australian Patent Application No.

27 2002345228, the entire disclosure of each is incorporated herein by reference. This invention relates to mixtures with insecticidal properties comprising two or more active

ingredients, to compositions containing them and to methods of controlling unwanted pests using such mixtures or compositions. More particularly, the invention relates to mixtures containing gamma- 10 cyhalothrin [(S)-a-cyano-3-phenoxybenzyl(Z)-(lR,3/?)-3-(2-chloro-3,3,3-trifluoro-l-propenyl)-2,2- dimethylcyclopropanecarboxylate] and another compound having insecticidal, nematicidal, acaricidal, molluscicidal, fungicidal, plant growth regulating or herbicidal activity, to compositions containing the 2012201147 mixture and to insecticidal methods using such mixtures or compositions. The discussion of documents, acts, materials, devices, articles and the like is included in this 15 specification solely for the purpose of providing a context for the present invention. It is not suggested or represented that any or all of these matters formed part of the prior art base or were common general knowledge in the field relevant to the present invention as it existed before the priority date of each claim of this application. Where the terms "comprise", "comprises", "comprised" or "comprising" are used in this 20 specification (including the claims) they are to be interpreted as specifying the presence of the stated features, integers, steps or components, but not precluding the presence of one or more other features, integers, steps or components, or group thereof. Compounds having insecticidal, nematicidal, acaricidal, molluscicidal, fungicidal, plant growth regulating or herbicidal activity are hereinafter referred to as active ingredients. 25 (S)-a-Cyano-3 -phenoxybenzy l(Z)-( 1 R,3R)-3 -(2-chloro-3,3,3 -tri fluoro-1 -propeny 1)-2,2- dimethylcyclopropanecarboxylate and its insecticidal activity was disclosed by Bentley et al, Pestic. Sci. (1980), 11(2), 156-64. Combining gamma-cyhalothrin and one or more further active ingredients can provide useful biological effects such as synergy against important pests such as Heliothis virescens, Spodoptera 30 littoralis and Myzus persicae. There is therefore provided a mixture of gamma-cyhalothrin and one or more further active ingredients. It is preferred that the further active ingredient, other than gamma-cyhalothrin is an active ingredient having insecticidal, nematicidal or acaricidal activity. 35 Examples of suitable insecticides that may be used as a further active ingredient in the mixture of the invention may be any compound selected from: a) Pyrethroids, such as permethrin, cypermethrin, fenvalerate, esfenvalerate, deltamethrin, cyhalothrin (in particular lambda-cyhalothrin), bifenthrin, fenpropathrin, cyfluthrin, tefluthrin, fish safe pyrethroids 1b

(for example ethofenprox), natural pyrethrin, tetramethrin, s-bioallethrin, fenfluthrin, prallethrin or 5- benzyl-3-furylmethyl-(E)-(lR,3S)-2,2-dimethyl-3-(2-oxothiolan-3-ylidenemethyl)cyclopropane 2012

carboxylate or any of their insecticidally active isomers;

Feb b) Organophosphates, such as, methidathion, chlorpyrifos-methyl, profenofos, sulprofos, acephate,

5 methyl parathion, azinphos-methyl, demeton-s-methyl, heptenophos, thiometon, fenamiphos, 27 monocrotophos, profenofos, triazophos, methamidophos, dimethoate

2012201147 2012201147 27 Feb 2012 10 20 15 25 30 5

triflumuron, j) e) d) carbosulfan, c) fosthiazate fensulfothion, phosphamldon, f) h) g) triazamate, i) benzoate, imidacloprid, dieldrin; m) k) l) n) methoxyfenozide; o) q) p) r) s) t) u) having utility stemborer

Amidines, Organochlorino Pyrazoles,

Chloronicotinyl

Carbamates Benzoyl Phenylpyrazoles Diafenthiuron; Macrolides, Hormones Fumigant Organic Toxins Indoxacaib; Diphenyl

Chlorfenapyr, Pymetrozine; Pyridalyl. Diacylhydrazines,

of

particular In

the

ivermectin, of

addition

, specific or tin cloethocarb,

hexaflumuron, bendiocarb, ethers,

such agents,

such microbial

or mixture. diazinon;

thiacloprid, fonofos, compounds, (including such malathion,

pheromones;

such

targets as as compounds compounds

to

such insecticides

such as

such tolfenpyrad, chlordimeform

milbemycin,

such the

avermectins as phorate, For origin

carbofuran,

fenobucarb, as

as may

aryl as lufeuuron, major

acetamiprid.

chlorpyrifos,

as instance, such fipronil,

flufenoxuron diofenolan chloropicrin,

carbamates), halofenozide, such

be such such

phoxim,

(such chemical as

employed pyridaben,

spinosad as

cyhexatin,

or

as as

furathiocarb, vanilliprolo, or novaluron,

selective

propoxur, Bacillus

as milbemycins, endosulfan,

diofenolan,

or nitenpyram amitraz;

chlorpyrifos-methyl, pirimiphos-methyl, cartap)

or pyriproxifen; classes dichloropropane,

such

in

tebufenozide,

chlorfluazuron; or tebufenpyrad

2

insecticides the fenbutatin thuringiensis

azadirachtin;

methomyl

noviflumuron, or

as

etiprole

of ethiofencarb, mixture

benzene clothianidin, hopper fenoxycaib, or

pesticide for

thiamethoxain;

example

oxide or

chromafenozide if for and specific or

hexachloride,

methyl

acetoprolo; endo- appropriate pirimiphos-ethyl,

oxamyl; phosalone,

listed particular

fenpyroximate;

teflubenzuron,

or alanycarb, aldicarb, thiacloprid,

abamectin,

azocyclotin;

or insecticides bromide

above,

exotoxins;

or

crops,

for terbufos, thiofurox,

DDT,

pirimicarb, other or

or the emamectin

diflubenzuron, fenitrothion,

metam; for

(such

intended chlordane

pesticides

example

as

or

2012201147 27 Feb 2012 10 20 15 25 30 5

buprofezin) for regulators, acaricidal acaricidal fenazaquin, indoxacarb, emamectin safroxan active diflubenzuron). pyridalyl, acetamiprid, indoxacarb; methoxyfenozide, chlorpyrifos, mixture dimethyl-5-p-tolylimidazole-l-sulfonamide a-[N-(3-chlon>-2,6-xylyl)-2-mcthoxyacetainido]-y-butyrolactone, (SSF-129), 7281, (AC382042),N-(2-mcthoxy-5-pyridyI)-cyclopropanc (MON65500), benomyl, (CGA245704), carbendazim, CQA41397,

particular

ingredient zoxamido), Examples The The Examples 3-5-dichloro-fl-(3-chloro-l

(E)-W-methyl-2-[2-(2A-dimethylphenoxymcthyl)phenyl]-2-methoxy-iminoacetamide

of and

motilicides, ovo-larvicides, propargite

biloxazol,

such the

benzoate,

4-bromo-2-cyano-iV,A further for

further spirodiclofen, lambda-cyhalothrin,

or

thlacloprid, dodecyl insect profenofos, chinomethionate,

carbendazim

invention

it A/-(l-cyano-l^-dimethylpropyl)-2-(2,4-dichlorophenoxy)propionamide

use

alanycarb, as

is in

of of

spinosad,

hydramethylnon, lV-allyl-4^,-dimethyl-2-trimethylsilylthiophene-3-carboxamide

active in active one the species/stages

suitable

suitable and

bitertanol,

spinosad, imidazole.

rice such

mixture or

may fipronil, piperonyl

such lufenuron,

ingredient

ingredient may etoxazole, more

aldimorph,

as

chlorhydrate,

profenofos,

insecticide fungicides

be

dicofol

as

be

chlorothalonil, chlarpyrifos,

of blasticidin of

any pymetrozine,

clofentezine,

r

mcthoxyfcnozide,

employed. -dinicthyl-6-trifluoromethylbenzimidazole-l-sulphonainide,

may the

thiamethoxam, -ethyl- butoxide.

cyromazine, indoxacarb is

is compound bromopropylate

or invention

anilazine,

preferably more also

that

synergists pmpargite; chlorfenapyr,

carboxin, 1

-methyl-2-oxopropyl)-4-methylbenzamide S,

be

(KF-916, maybe preferably chlorpyrifos-methyl,

bromuconazole, 3 Alternatively

chlorozolinate, pirimicaib, included flubenzimine,

selected and include

azaconazole, methoprene, one

abamectin, insecticides

carpropamid,

acaricides, chlorfenapyr, lambda-cyhalothrin. used

or or

carboxamide,

pyridaben, cyamidazosulfamid), one

in piperonyl

chlorobeazilate; more from:

as

methidathion, the

insecticides a or

hexythiazox

emamectin further chlorfluazuron clozylacon, bupirimate, of mixtures azoxystrobin, more

that such

thiamcthoxaxn,

carvone, emamectin

profenofos, 4-chloro-2-cyano-A pyridaben, butoxide,

may

acibenzolar of as

active

thiacloprid,

acequinocyl,

or (for be

imidacloprid,

or

benzoate,

or copper acaricides captafol,

CQA41396, used

growth ingredient example benalaxyl,

sesamex,

tetradifon;

benzoate novaluron,

or lufenuron,

as abamectin, containing

fipronil,

a captan, spinosad,

further specific

r (RH- JV-

in and

the

2012201147 27 Feb 2012 20 15 10 25 30 5

compounds disulphide and imazalil, fenpropimorph, fenarimol, oxycaibonyl)amino]thio)-P-alaninatc, ethirimol dimethyl dimctconazole, difenzoquat, fuberidazole, flumetover, mctominostrobin, mefcnoxam, kasugamycin, iprodione, mixture propyl, phosetyl-Al, oxpoconozole, probenazole, ammonium acid, thiophanate-methyl, tecnazene, sodium triadimenol, triforine,

Bordeaux A. C. B.

pyrazophos,

nuarimol,

Examples acylanilidee dimethylpyrazoles pentachlorophenate, l,2,4-triazin-5-ones of

imibenoonazole, , ammonium

triflumizole,

ethyl(Z)-?/-benzyl-A

iprovalicaib fenbuconazole, Ι,Γ the-

tetraconazole,

such fluoroimide,

compounds,

diflumetorim,

mepanipyrim, phosphorus triazbutil, prochloraz, furalaxyl,

kresoxim-methyl, mixture, -dioxide,

invention

oxycarboxin,

dimethomorph, fentin

as

ofurace, pyrifenox, myclobutanil, of

copper

such thiram, chloride, suitable

acetate,

triticonazole,

cymoxanil, (SZX0722), triazoxide, furametpyr, dichlofluanid,

may quinomethlonatc, fluquinconazole,

acids, procymidone,

thiabendazole, as

iminoctadine,

fenfuram, organomercuiy

oxychloride, such O,O-di-iro-propyl-S-benzyl mepronil,

such pmpanil timibcnconazole, pefurazoate,

spiroxamine, pyrimethanil,

be

r fentin ([methyl(methyl-thiocthylideneaniino- dodemorph,

dimethirimol, phthalide,

as LY186054, neoasozin, any

as

tricyclazole, cyproconazolc, benzofenap,

isopropanyl guazatine,

metamitron

validamycin compound fenhexamid hydroxide,

metalaxyl, etridiazole, diclomezine,

propamocarb,

copper

iminoctadine that thifluzamid,

penconazole,

picoxystrobin flusilazole,

compounds,

streptomycin, quinoxyfcn, dodine, pyroquilon,

nickel

LY21 may

4 diniconazole,

tolclofos-methyl, hoxaconazole,

oxyquinolate,

tddemorph·,

pyrazolynate

selected

butyl ferbam, and

metconazole,

(KBR2738), A, be famoxadonc,

1795, cyprodinil, dimethyldithiocarbamate,

doguadine, dicloran,

vapam, used

2-(thiocyanomcthylthio)bcnzothlazole, flutolanil, carbamate, triacetate, propiconazole,

oxadixyl, thiophosphate, pyroxyfur, pencycuron, quintozene,

LY248908, (ZA1963), fcrimzone, from: sulphur,

as

dinocap,

trifloxystrobin

vinclozolin,

a

diethofencarb, (pyrazolate)

hydroxyieoxazole, copper

debacarb,

fenpiclonil, further

metiram, edifenphoa, fenamidone

tolylfluanid, flutriafol,

ipconazole,

oxasulfuron, isoprothiolane, tebuconazole,

pyrrolnitrin,

polyoxin sipconazole

fluazinam,

phenazin mancozeb,

dithianon,

sulphate,

propineb,

active dimefluazole,

metiram-zinc, di-2-pyridyl

zineb

and

fenpropidin, folpet, epoxiconazole, (COA279202),

(RPA407213),

difenoconazole,

ingredient

iprobenfoa, nitrothal-iso- D, triadimefon,

oxide,

pyrazoxyfen. oxolinic

copper

quaternary and fludioxonil,

dodecyl

propionic

maneb, tecloftalam, polyram,

(F-155), hymexazole,

ziram.

tallate

in

acid,

the

2012201147 27 Feb 2012 20 10 15 25 30 5

D. H. F. E. G. J. I. K. L. M. N. P. Q. D. R. S. T.

isoxaben, amino amide thereof, fenoxaprop clodinafop-propargyl, and methyldymron, thereof, diuron, aryloxyprcrpionates, bipyridyliums benzoic arylanilidcs bcnzo-2, arylureas isomere carbamates carbamates , cyclohexanediones cycloxydim, dihalobenzonitriles diphenyl dinitrophenols acetamides chlomethoxyfen, , dinitroanilines haloalkanoic precursors hydroxybenzonitrile

sulfosate.

herbicides acids

fenuron,

propaquizafop, thereof, acids

1

and euch ethers naproanilide, ,3-thiadiazin-4-one-dioxides

such & such such such propisochlor such and

, oxyfluorfen.

such herbicides esters such as

such metobromuron,

such

prodiamine such

salts fluometuron, metazachlor, as as as such as as chlorbromuron, chlornitrofen,

as

chlorpropbam as salts desmedipham bromofenoxim such diflufenican,

acetochior, including such

thereof as

as

as and (HBN)

cyhalofop-butyl, 2,3,6-trichlorobenzoic as

dinoterb napropamlde,

dinitramine, quizalofop

aciflurofcn

and

benfluamid,

such as

as and esters tepraloxydim

alloxydim

dichlobenil eg and

esters herbicides and

thenylchlor. the isoproturon, as

ethyl

metoxuron, ,

thereof,

fluroglycofen and .

dalapon

flamprop, salts chlorotoluron, optically

and and

and

thereof, and

ethalfluralin, dintro ester,

bromobutide, naptalam,

5

and phenmedipham thereof, propham,

such diclofop esters

such salts and

such

, and

-butyl, salts and

isouron,

active ortho-cresol

flamprop-M

, as tralkoxydim.

acid,

and as thereof as trichloroacetic

or

bcntazone and isomers

thereof,

propyzamide &

daimuron and

salts esters

isomers fluchloralin,

esters

dimethachlor, carbetamide, iinuron,

phenylcarbamoyloxyphenyl and

or

and

thereof, thereof,

(DNOC) butroxydim,

and ester thereof

quizalofop-p-tefuryl

neburon thereof,

and

(dymron), haloxyfop salts

and methabenzthiazuron, and esters acid

and

thereof,

oryzalin, and salts

pretilachlor, ,

and ioxynil,

eg salts

flufenacet,

and

tebutam

such and thereof

methyl

and

esters

clethodim,

dimefuron, and thereof. salts

,

tcbuthiuron

as

esters and

esters

, thereof. thereof, ester,

HBN

and

2012201147 27 Feb 2012 20 10 15 25 30 5

U. W. X. V. Z. Y. DD. BB. HF. EB. CC. AA. HH. OG.

benazolin, -p, isopropylammonium thioethyl, dichloropheuoxyacetic hormone fluazolate, imidazolinones & pyridate, oxadiazon, flurenol-butyl, dimexyflam, thereof miscellaneous organoarsenical monDsodium organophosphorus

eodium, methyl fcncWorazolc-cthyl, dichloromcthyl-2-methyl'l,3-dioxolane decane oxabentrinil, and

quinolinecarboxylic pyridazinones pyridones phosphorothioates pyrimldlnyloxybenzoic -p, sulfamoylureas sulfonanilides mctosulam.

eg isothiocyanate (AD-67),

bispyribac-sodium,

herbicides isoxachlortole, 4-(4-chloro-2-methylphenoxy)butyric

methyl

benzobicyclon/benbiclon,

fentrazamide, antidotes oxaziclomefone,

such

,

diphenamid, methylarsonate mefenpyr-diethyl,

herbicides flurochloiidone,

such such herbicides

such

, as

3-dichloroacetyl-2,2,5-trimethyloxazolidine sulphate such

herbicides

fluridone such

such such as fenclorim, salts as

acids as

precursors acid, thiazopyr as

irnazapic, chloridazon

isoxaflutole chloraneulam-methyl, as

flucarbazone,

such

acids cyclosulfamuron. as as , thereof,

salt,

such

such 2,4,5-trichlorophenoxyacetic

2,4-dichlorophenoxybutyriG pentoxazone, benoxacor, pyriminobac-methyl butamifos, 4-chIoro-2-methoxyacetic

(MSMA)

such as

and

diflufenzopyr-sodium flurtamone,

fluxofenim, N-(dichloroacetyl)-l-oxa-4-azaspirobicyclo-(4,5)-

as

and as

ammonium such imazamox,

imazaquin

disodium

as quimerac salts

epoprodan, and

cinmethylin, . and anilofos 6

as

flumiclorac-pentyl,

cloquintocet-mexyl, norflurazon (MO-191). and

sodium dazomet

pyraflufen-ethyl,

fhithiacet-methyl, furilazole,

esters methylarsonate sulfamate, imazamethabenz-methyl, and and

and

diclosulam,

acid ethofumesate,

chlorate.

and imazethapyr. , and

fosamine-sodium thereof,

(MCPB),

. (SAN-835H), piperophos

naphthalic acid

,

acid, acid,

flumioxazin,

florasulam, such pyridatol/pyridafol, (MCPA),

dichlormid, (DSMA)

, difenzoquat , (R-29148) mecoprop 2,4- etobenzanid,

azafenidin, as

anhydride,

pyrithiobac- dlmethipin,

MCPA- and

flumetsulam

flupoxam,

& and dichlorprop

& mefenacet,

salts 2-

&

2012201147 27 Feb 2012 20 IS 25 to 30 5

ingredient calcium, A47gibberellin chlonnequat susceptible formulated die inert which insecticidal liquid/liquid other possessing

MM. LL. NN. KK. JJ. Π. 00. plant

diluent

properties

are prosulfuron, nicosulfuron, thifensulfuron-methyl, ethametsulfuron-methyl, chlorimuron dipropylthiocarbamate prosulfocarb, mcthyl sulfonylureas Examples prometryn, methyl, thiocarbamates In

In triazole

triazine triketones uracils thiadiazuron, or

triazolinones

order one in able

insecticidal, into

to seed, compositions

or chloride, the interfaces)

attack

particular

A7,

ethoxysulfuron, to a carrier

to

such herbicides (for mixture herbicides

to of composition modify

apply propazinc,

maleic such

pyrazosulfuron-ethyl, &

soil

suitable by oxasulfuron, thiobencarb, example such as

, esters

and, trinexapac such such

a

bromacil, nematicidal, by or

as the aspect

of the pest,

comprising as hydrazide,

such to sulcotrione lowering

optionally, such

the

as

active as eg plant amidosulfuron,

properties

, any dispersion, triasulfuron,

(EPTC),

butylate, which or,

carfentrazone-cthyl imazosulfuron,

the Invention ethyl

,

as flumetralin, as

ethyl tiocaibazil, other primisulfuron lenacil as growth

ingredients

amitrole. present ametryn,

the

a ester acaricidal,

includes, mepiquat

gamma

fungicide

a and esprocafb,

and growth of simetryn,

cycloate,

interfacial surface

emulsification may and rimsulfuron, regulators

an thereof,

tribenoron, invention . uniconazole.

azimsuifuron,

,

flurprimidol,

7

interface tri-allate terbacil.

cyhalothrin be

flupyrsulfuron

to

in iodosulfuron,

medium, chloride,

molluscicide!,

& active

to

a

dimepiperate, any , addition

molinate,

chlorsulfuron, estera pest, and tension a

that plant, therefore

compound

,

tribenuron-methyl

and (for aulfometuron-methyl, agent .

a

and

the paclobutrazol, may eg

locus

and

to gibberellic

vernolate. bensulfuron and example, to

methyl

orbencarb,

active wetting).

(SPA). the metsulfuron

and

a bo

one fungicidal, also

thereby seed S-ethyl of

selected

active used

terbutryn dimethametryn, cinosulfuron, salts

or pest,

ingredients provides ester

of liquid/solid, SFAs more

acid, as

thereof,

pebulate, leading ingredients, a and or prohexadione

a thereof, plant,

and from and

plant

to

further compounds and gibberellin are

esters

novel

a

sulfoBulfuron. triflusulfuron-

esters

plant chemicals

are ancymidol,

trietazine. halosulfuron- to to growth

, liquid/air the

changes active thereof,

usually a

thereof,

suitable locus

in

of or

8

regulating or herbicidal activity, an insecticidally inert carrier or diluent and, optionally, one or more

2012 surface active agents.

It is preferred that the ratio of gamma-cyhalothrin: other active ingredients is in the range

Feb 1:100 to 100:1 (for example 1:10 to 10:1) weight/weight.

5 It is preferred that the composition contains at least one compound other than gamma- 27 cyhalothrin having activity against insects, acarines, or nematodes. It is preferred that all compositions (both solid and liquid formulations) comprise, by weight, 0.0001 to 95%, more preferably 1 to 85%, for example 5 to 60%, of active ingredients. The composition is generally used for the control of pests or fungi such that the active ingredients are 10 applied at a rate of from O.lg to 10kg per hectare, preferably from lg to 6kg per hectare, more preferably from 1 g to 1kg per hectare.

2012201147 When used in a seed dressing, the active ingredients are used at a rate of 0.000 lu to lOg (for example O.OOlg or 0.05g), preferably 0.005g to lOg, more preferably 0.005g to 4g, per kilogram of seed. 15 In one aspect the present invention provides a mixture of gamma-cyhalothrin and chlorpyrifos. In another aspect the present invention provides an insecticidal composition comprising gamma-cyhalothrin, chlorpyrifos and one or more insecticidally inert carrier or diluents. In a further aspect, the present invention provides a method of combatting and controlling insect, acarine or nematode pests at a locus which comprises treating the pests or the locus of the pests 20 with an effective amount of a mixture comprising gamma-cyhalothrin and chlorpyrifos. A further aspect of the invention is a mixture of gamma-cyhalothrin and one or more further active ingredients having insecticidal, nematicidal or acaricidal activity wherein the further active ingredient is one or more of thiamethoxam, abamectin, emamectin benzoate, spinosad, chlorpyrifos, chlorpyrifos-methyl, profenofos, lufenuron, indoxacarb, lambda-cyhalothrin, pymetrozine, 25 methidathion, imidacloprid, acetamiprid, thiacloprid, fipronil. methoxyfenozide, chlorfenapyr, pyridaben, novaluron, pyridalyl and piperonyl butoxide. A further aspect of the invention is an insecticidal composition comprising gamma-cyhalothrin and one or more further active ingredients having insecticidal, nematicidal or acaricidal activity wherein the further active ingredient is one or more of thiamethoxam, abamectin. emamectin benzoate, 30 spinosad, chlorpyrifos, chlorpyrifos-methyl, profenofos, lufenuron, indoxacarb, lambda-cyhalothrin, pymetrozine, methidathion, imidacloprid, acetamiprid, thiacloprid, fipronil, methoxyfenozide, chlorfenapyr, pyridaben, novaluron, pyridalyl and piperonyl butoxide, an insecticidally inert carrier or diluent and, optionally, one or more surface active agents. A further aspect of the invention is a method of combating and controlling insect, acarine or 35 nematode pests at a locus which comprises treating the pests or the locus of the pests with an effective amount of a mixture comprising gamma-cyhalothrin and one or more further active ingredients having insecticidal, nematicidal or acaricidal activity wherein the further active ingredient is one or more of 8a

thiamethoxam, abamectin, emamectin benzoate, spinosad, chlorpyrifos, chlorpyrifos-methyl,

2012 profenofos, lufenuron, indoxacarb, lambda-cyhalothrin, pymetrozine, methidathion, imidacloprid,

acetamiprid, thiacloprid, fipronil, methoxyfenozide, chlorfenapyr, pyridaben, novaluron, pyridalyl and

Feb piperonyl butoxide.

5 A further aspect of the invention is a mixture of gamma-cyhalothrin and spinosad. 27 A further aspect of the invention is an insecticidal composition comprising gamma-cyhalothrin,

spinosad and an insecticidally inert carrier or diluent and, optionally, one or more surface active agents. A further aspect of the invention is a method of combating and controlling insect, acarine or nematode pests at a locus which comprises treating the pests or the locus of the pests with an effective 10 amount of a mixture comprising gamma-cyhalothrin and spinosad. The formulated compositions can be chosen from a number of formulation types, including

2012201147 dustable powders (DP), soluble powders (SP), water soluble granules (SG), water dispersible granules (WG), wettable powders (WP), granules (GR) (slow or fast release), soluble concentrates (SL), oil miscible liquids (OL), ultra low volume liquids (UL), emulsifiable concentrates (EC), dispersible 15 concentrates (DC), emulsions (both oil in water (EW) and water in oil (EO)), micro-emulsions (ME), suspension concentrates (SC), aerosols, fogging/smoke formulations, capsule suspensions (CS) and seed treatment formulations. The formulation type chosen in any instance will depend upon the particular purpose envisaged and the physical, chemical and biological properties of active ingredients. Dustable powders (DP) may be prepared by mixing the active ingredients with one or more 20 solid diluents (for example natural clays, kaolin, pyrophyllite, bentonite, alumina, montmorillonite, kieselguhr, chalk, diatomaceous earths, calcium phosphates, calcium and magnesium carbonates, sulphur, lime, flours, talc and other organic and inorganic solid carriers) and mechanically grinding the mixture to a fine powder. . Soluble powders (SP) may be prepared by mixing the active ingredients with one or more 25 water-soluble inorganic salts (such as sodium bicarbonate, sodium carbonate or magnesium sulphate) or one or more water-soluble organic solids (such as a polysaccharide) and, optionally, one or more wetting agents, one or more dispersing agents or a mixture of

30

35 2012201147 27 Feb 2012 10 20 15 25 30 5

granules in diatomaceous ingredients granulated dispersing or powder. said solution porous commonly mineral other aromatic in agent as crystallisation contain dissolving wetting N-alkylpyrrolidones solvents alkylnaphthalenes, EC methylcyclohexanone) SOLVESSO of

liquids. more water polyvinyl

fatty

agents product

additives or

Wettable granular Granules Dispersible

Emulsifiable

carbonates, a solid by acids agents, thereof,

dispersing or Similar for petroleum

surface

agents

to The

used the to absorbing an and

use may acetates,

form

is diluents improve

earths (such organic

in

active

may

mixture one

one material a

to

in powders in (GR) compositions

a and, spontaneously active Registered

aid water

spray ECs

Concentrates a exemplified agent).

or solvents, sulphates

as or also

or

concentrates suitable

(such

ingredients

the polyvinyl

or optionally, solvent, absorption more may water C more

ground

and is include agent

8 be carriers,

(such tank). dispersible

-Ci active (WP) then

as

be

included

alcohols powdered

0 emulsifying Trade dispersibility/solubility.

alcohols, agent)

N-methylpynrolidone or fatty

(for

formed

may as such com ground

may

ingredients alcohols, aromatic by emulsify

phosphates)

in

(DC) one pumice, one

or

(EC) example

SOLVESSO acid Mark),

also an

cobs) as on granules adsorption

bo (such in

or or

either

organic to solid

may ethers,

a

to prepared or granules

dimethylamide) be more ketone, more

agents a hydrocarbons

dextrins,

on

a or

attapulgite oil-in-water

ketones

as fine

granulated to hard be

diluents

(or by

by addition and (WG).

9

benzyl

wetting improvo ketones suspending prepared solvent

powder.

granulating include

adsorbing a

or

alcohol 100, (for core

by drying solution

sugars a

(such

or mixing

mixture

or

example alcohol,

clays, SOLVESSO to material The

N-ocfylpyrrolidone), agents to and

(optionally emulsions

water

carriers,

(such

solvents

by water,

if

and or Similar form

as

and

the

thereof, agents mixture necessary. esters) a

dissolving

glycol fuller's the cyclohexanone

chlorinated

of mixture and, dilution

furfuryl as

active vegetable an

(such water to

active

said or

alkylbenzenes (such

compositions

emulsifying to

produce (EW)

ether. and

containing preferably,

in is 150 from earth,

facilitate

ingredients agents). as

soluble

then

a

of or alcohol ingredients the sticking Agents

as

suitable and sands,

may

oils). pre-formed the prevent

hydrocarbons. These

aliphatic

kieselguhr,

active ground an

SOLVESSO or

dimethyl

active

granules be

the

emulsion one one Suitable agent, which or

silicates,

One agents

may

or

agent) solutions

prepared

ingredients (or butanol), dispersion

or to with or

and

or

a also

wetting more blank a

more are

amides

(SG). (such

fine more

in

organic

one with

An

be

200; a by may

2012201147 27 Feb 2012 20 10 15 25 30 5

solvents or emulsion. temperature, isotropic and (euch solution an sufficient be described the ME system finely conventional wetting or dispersing to desired dry example medium compositions form compound.

solution

BW reduce bead suitable

solvent/SFA

other milled is

as

a divided

suitable

involves Microemulsions

(which Suspension

composition Aerosol with The milling end agents chlorobenzenes), (by

liquid

(for

n-butane). appropriate stability the

for

into Suitable agents, and for

product dissolving active it

one

oil-in-water use rate example

for insoluble

mixing may system for

may water added formulation.

the

obtaining formulations blend.

or in

at use

to to dilution

ingredients

solvents concentrates be active more in be

which

allow suitable Hie

produce containing

organic

to

in

is water-soluble ECa melted

water included it

Suitable

(ME)

solid

water, non-pressurised, present

in

active

SFAs, emulsion. aromatic ingredients the

into spray

the or an

for

or

The

for

particles solvents comprise a active at

in may

appropriate

particles may

containing

water, fine a

use

ingredients

in

a one to may EWs. (SC) generating, solvents application

water

acdve reasonable

be the produce

solvents

be in

particle

ingredients or and

be

prepared in

may

either EWs

which composition mixed

of

more

An miscible the

settle. ingredients determined a oil-soluble

for hand-actuated the

suitable

agents

solvent) comprise

MB

active

spontaneously may include

(such suspension

in remaining

through

use SFAs, 10 have active temperature, in

Alternatively, by an may

the either

liquid, also

in

hereinbefore

ingredients

mixing enclosed as medium,

a

and and MBs dry

vegetable under ingredients.

are by

be pesticides low

aqueous alkylbenzenes appropriate be

as

conductivity either as then

state present such a of

dissolved

spray

solubility

include a

suspending

water a high

the typically a liquid

space, microemulsion

optionally thermodynamically

emulsifying

with as

or the and an

oils,

compound. pumps.

described, in

shear, initially

n-propanol)

non-aqueoue with

oil-in-water

SCs those equipment

active the (if

a a

a or in chlorinated

suitable or pyrotechnic below

smoke it measurements)

dispersed same

a water. agent may to

alkylnaphthalenes)

is

with hereinbefore blend

ingredients

in

produce not

to the

be either

70°C) One formulation.

containing

may or

one

propellant produce

to a

or of resultant Preparation prepared

suspensions

forming liquid

provide hydrocarbons

in

or

a

one mixture or be stable

the or an

water-in-oil

a more

more

included

suitable may

in

or and

water at the

the

liquid

by more (for a room

may be to An

of ball

of

or

2012201147 27 Feb 2012 20 10 25 15 30 5

procedure. EW and shell contains of performance biodegradable example blends example ingredients). on respectively, composition, action (CS). soluble treating cationic, example (for monoesters dodecylbenzenesulphonate, aromatic sulphates isopropyl-

oil surfaces;

they formulations

example may

droplets

The of of Capsule

A The Wetting

Suitable powder Suitable

seed

may the certain

as

cetyltrimethyl the anionic, these composition

compounds be

(for

preparations

Hie and

a active

resistance of active

produced active of DP, may powder including Such

a

be

is polymeric

example

sulphuric

mineral with the

tri-isopropyl-naphthalenc suspensions

(SS) compositions

mineral agents, SFAs obtained, anionic

used

but SP,

amphoteric include Ingredients

ingredients

additives composition ingredients.

other

or

with composition, WP,

(for

for may to by of

a

oil a

ammonium dispersing sodium of

oils SFAs

matrix acid

flowable rain water the

either seed

bio-enhancing

an in example an DS, SC or

include

(CS)

butylnaphthalene

or include

which cationic

agent additional

a or on

may (for may

and, and

treatment,

SS, film-forming

natural include dispersible

laureth-3-sulphate), an to (for non-ionic treated

may

example

DC concentrate provide provide

agents interfacial WS, including for also

optionally, sodium one each bromide),

example surface

type

be assisting compositions plant

alkali be or

polymerisation FS

surfaces;

oil adjuvants prepared sulphonates),

and

more the

include

formulated

type.

powder for a sodium dodecylbenzenesulphonate,

and

droplet

active oils

slow, barrier).

a 11

metals by

polycondensation emulsifying active

imidazolines sulphonate controlled a (FS), powder

LS

the additives

carrier improving (such

or

quaternary

controlled in

for agents, lauryl

compositions (ingredients adhesion is

ether ingredients uptake a salts described a

encapsulated solution for

elurry

as for manner ether or stage

release soy

sulphate), use carboxylates and of to

diluent agents dry spray

or wetting, and

improve

fatty

treatment

sulphates, of

such release

bean as ammonium

mixtures

seed mobility

above. (LS)

similar

the which reaction amine

may a

additives

of

are may acids, therefor. seed

that

and

composition treatment the by

salts or

retention

very of also the

be a

may

salts.

a

to Compositions (for an (WS), rape treatment, active

of calcium of alcohol the

salts

polymeric

capsule or

biological

of the surface

be aqueous compounds

similar the sodium based

by compound. example The

aid sulphonated seed

formulated of preparation

(DS), or ingredients active or a

or

ether aliphatic

coacervation polymeric

to as

Buspension on distribution

SFAs oil),

to modify for

di

dispersion

the shell a

a

oils,

­ those

sodium

liquid

for water and (for

seed of

in

and for of

the

the of,

a

2012201147 27 Feb 2012 20 10 15 25 30 5

fatty laureth-3-carboxylate), paraffin tetraphosphoric (predominately fatty alcohols such bentonite polyvinylpyrrolidone oxide); (comprising anhydrides; nonylphenol pesticidal foliage, unformulated, plants growing applied paddy composition through control construction films termites.

alcohols acid as

or water are

Suitable Suitable Suitable The

and ethylene The The

pests. by stems, or

distribution (such plant sheets

polyethyleno

or or

growing

olefine dipping,

lecithins.

condensation active

active ethylene active attapulgite).

or

fungicidal or

packed or and

liable to as

branches

di-esters), octylcresol);

hydroponic used acid; SFAs SFAs suspending agricultural oxide,

the oleyl

phosphoric

sulphonates, ingredients

ingredients ingredients or

applied

to or pests in in additionally oxide

or are of of

alcohol

phosphate glycol

propylene infestation compounds. incorporation the a

sodium

or the thenon-ionic

water-soluble to products for or

construction roots,

culture and

agents as be industries. partial amphoteric

to example

acid estora);

may may may

or a planted

taurates

propylene a

carboxymethylcellulose) cream

cetyl locus these to esters

oxide,

(predominately by

include

of be systems), esters also

also the

For

the said amine of

applied

the

type

alcohol)

or (such

products bag) of

They and seed (products bo of be type a

butylene example, pests)

derived paste composition the partial reaction

oxide);

buildings hydrophilic

incorporated incorporated

include

lignosulphonates. oxides

in

before

directly include 12 as

may, pests by

soil

formulation, or or soil

may any esters

oxide from

alkanolamides; mono-esters) from

to with it between

for

or (such

(for condensation it surrounding

may to any

or of betaines,

be is

an

example,

(such colloids protect long

with alkylphenols the

it example the

or planted into ethoxylated), into

aqueous part

and as be may

mixtures

reaction known lauryl

a

chain

ethylene applied, applied bait materials

as

swelling of habitat

propionates be them

(such or a

or be the

the lauryl

products stations

granular

simple environment. sprayed

alcohol

fatty phosphorus

to means

incorporated

between

plant,

thereof, roots, from

as

(such

formulated of other

as oxide;

sulphosuccinamates,

clays

used

dimethyl a

acids

the polysaccharides,

eaters vapour

used

and pests of

on, including of composition

as and the media

pests,

in

(such with block

one applying

or

alkylene octylphenol,

dusted

pentoxide soil the to

glycinates. (for

such

hexitol

into or amine or

or attract

fatty

in or

as polymers generally,

applied

more example

the

which a as plastics on,

oxides,

or

and

a

2012201147 27 Feb 2012 20 10 15 25 30 5

or using withstand include ingredient, generally depending enable water include nitrogen-, contain from active a of optionally the active compartment components gamma-cyhalothrin solid example Coleoplera acarine

fertiliser

aerial insect

components

0.1 electrodynamic or

to

The ingredients. ingredient them The

Compositions

The The DCs, varying

The granules In

irrigation or

form liquid

pests to supplied

by

storage potassium-

mixture and upon in another

the nematode

active

6 active

amount

(including

contents to mixing

may

SCs, combination

kg aqueous

which

concentrate gives the be diluent

amounts

the may per of

optionally

be for

applied ingredients

ingredients systems. in ECs, active aspect

of The

fertiliser.

purpose

of

both optionally hectare. a

presented

contains

die

be prolonged spraying of include for or

the

rate

preparations composition Diabrotica,

invention EWs,

the

presented

phosphorue-containing

form

of

ingredients. use in invention the

by

with being of

the two

water in

for

conventional as

insect present

active

may The a may

MEs

of

techniques

combination in in a

active

further

aqueous periods which containers

added a

solid a combination

therefore

prior

mixtures in concentrate also

be that

two SGs,

which is pests of ingredient

invention separate

used ingredients preferably

the

they or

active

be to is,

pack-container, to

and,

preparations

SPs,

such

liquid

or water com present injected administration. remain

spray

or

in also are suitably with

other after

13

ingredient

the containers, WPs,

mixtures

as from with containing rootworm), to provides

fertilisers). before diluent, provides

equipment.

presented

a

Lepidoptera,

two

(for

be homogeneous invention such

low into solid

WGs a 0.01 contain

used.

(aqueous solid compartments example

volume

use. plants storage,

with

one or optionally and

a

a

to

one

andCSs, a method

in liquid

or pests fertiliser

high compartment 10 generally

Suitable up These the fertilisers

Such

containing a liquid or

Diptera,

kg methods, 0.0001

solutions single to

to

second for .associated sprayed proportion

diluent

per 25%

be

of

aqueous concentrates, in are a

diluent composition

can

combating formulation

capable combination sufficient composition. hectare,

applied

to

(for often by

Homoptera. containing

or

then gamma-cyhalothrin

onto or

10%, of

Alternatively weight

example

preparations applied dispersions) with and of

which required

of be

for vegetation

preferably

the by

time

a insect, addition

which admixed, agriculture

comprising tho types

of

second

weight) active

with a contains and by

However

the

further to

control to

land

may

a the

may are

to

for

2012201147 27 Feb 2012 20 10 15 25 30 5

americana (which animal animals. and Phaedon (housefly), gossyp (mosquitos), Tetranvchus mite), Helioihis lugcns (rootworms), (white Nephotettixc Lygus invention (citrus Aonidiella Leptinotarsa Leptocorisa Plutella virescens (cotton Ostrlnia (rootworms), stem Brevipalpus mite), Tetranychus

timber,

borer),

Panonychus

ii spp. flies), rust (planthopper), husbandry, Phyllocoptruta term

Examples

bollworm),

(aphid),

xylostella

cochloariae nubilalis Examples

virescens (cockroach), include: (tobacco

Pieris mite), spp. (capsids), and

spp.

includes

ni,

Culex Bemisia Locustamigratoria spp. incticeps urticae A decemlineatu Panonychus

grotis Tetranychus also (scale

Aphis

braBsicae (stinkbugs), Polyphagotarsonemus of

(flat

forestry, Afyzui (European

citri

(diamond budworm), (tobacco spp. Sylepta of

those

pest

(mustard

the

(two-spotted Dysdercus spp. Neohotettix

tabaci

insects), insect

(leafhopper), Blatta oleivora mites), fabae

(citrus (mosquitos),

growing

species persicae

pests (cutworms),

ulmi (white (Colorado the

derogata

(white budworm) cinnabarinus

and

back orientalis (aphid), com

Frankliniella

Boophilus beetle),

red

Helicoverpa storage

Trialeurodes

(citrus associated (Buropean

spp. acarine which (locust),

of

cmcticeos butterfly),

mite), spider moth), bartt),.Spodoptera

(aphid). fly),

Nezara crops

Dvsdercus (cotton (capsids),

Aedes

potato

Aonidiella rust

of Chilo

(cockroach)

Chortiocetes

may Blattdla

latus

Tetranvchus pest microplus

mite),

products Agro'tis

Chortiocetes (carmine

for

with red mite), Aphis

occidentalis armigera

spp. Plutella

be (leafhopper), aegvoti

Bpp. beetle), leaf partellus 14 species

(broad food

mite),

Nilaparvata controlled Tetranychus

the

fasciatus

(stinkbugs),

germanica roller), gossypii spp. (white Polyphagotarsonemus spp.

of

and

transmission spider (cattle Spodoptera

(mosquito), mite) terminifera xylostella Anthonomus

include: Panonychus

vegetable

urticae

(cotton littoralis (scale (maize (cutworms),

fibre terminifera

(thrip), flies), Pieris

(capsid),

Panonychus by mite), tick), (aphid), and

(cockroach), lugens insects),

products), cinnabarinus

(two-spotted

Euschistus the bollwonn), stem Mvzus

Bemisia Brevipalpus

(diamond

(cotton brassicae origin,

Thrips littoraliB

Dermacentor

(locust), Phvllcootruta Anopheles of compositions

citri grandis

Aphis Musca

borer), (locust), diseases Chilo (planthopper),

persicae Trialeurodes

ulmi such

(citrus spp. leafwonn), horticulture tabaci

latus spp.

fabae (cotton

Diabrotica Perwlaneta

back Helicoverpa suppressalis

(white

domestic» Nilaparvata spider (carmine (boll

spp. (thrips), as (European Diabrotica spp. of

(stinkbugs),

red (aphid). (broad variabilis

(white

fruit, moth), man oleivora of

(aphid),

weevil),

(mites). leafwonn),

butterfly), mite),

the mite),

spp. Heliothis

and

and spider

grain

spp.

mite),

fly),

zea

Aphis

(rice

red

spp.

2012201147 27 Feb 2012 10 20 15 25 30 S

Damalinia domestica (American sulphureus), Rhinotermitidae eelworm), R example americana (mosquitoes), nematodes), nematodes), nematodes), nematicidally (slug). molluscdcidal, cyhalothrin acarines, peet, the or antisporulant Potter was Synperonic instar room

virginicus, seed,

fungicidal

uecd. or

The at Heliothis Tower, The The

Test to

to Mastotermes 25°C nematodes

(housefly), a Trichostrongylus dog invention (cockroach), Boil spp.

For

invention and term

plant

NP8 Rhodopholus Haemonchus Globodera compositions Solenopsis

R. LucUlia treatments.

or

method

for fungicidal, left

tick), or Heliothis

and

one

virescens/Spodoptera Hesperus, (for molluscicidally

with "plant"

to susceptible

3 to

Linognathus days

or any or

example is Ctenocephalidesfelis

dry Aedes

therefore

spp.), spp. the

Of

more illustrated molluscs

spp. Blatta geminata

other

as for and the and

plant coniortus exception

spp. and were

(blowflies), used

aegypti

spp. the

and compounds

invention 1

Spodoptera to the

Coptotermes

growth R. hour orientalis

(banana

provides

growth Kalotermitidae made

attack

Heterodera effective herein which (gastro spp. test santonensis) by (fire

and (barber (mosquito),

of

the species

(biting medium up

littoralis by

ant),

Blattella

includes spinosad, regulating burrowing

comprises includes

then EXAMPLE

intestinal following

a possessing (cockroach),

from

testing a amount method

formosanus,

(cat

pest, pole Monomorium

placed spp. and 15 assessed

and

technical (for

flea),

(for

larvae. protectant,

germanlca Anopheles

seedlings,

worm), to

cotton for sucking

(cyst

or of nematodes) allying nematodes),

of

the Bxamples. example

a

example on insecticidal,

herbicidal which 1

a Uriomyza seed combating

termites for Termitidae

mixture

nematodes),

These the

leaves Reticulitermes active Caenorhabdltis

lice), mortality. pharaonis of

top

bushes curative, Tracer spp. an (cockroach),

a

Neotermes a

were

nutrient

and insecticidally,

plant,

were of of containing ingredient

Tylenchtdus Meloidogyne

activity

spp. (mosquitoes),

and

nematicidal,

the pots

(for 480SC Deroceras and

stored

Praiylenchus

sprayed

controlling (leafininer), systemic, to Mastotennitidae (pharaoh For

containing

example solution).

flavipes, trees.

to the

spp.),

Periplaneta

elegans/ybaegu

aphid

in in a diluted gamma-

locus

pest,

spp.(citrus

in 0.05% spp.

a acaricidally,

Furthermore,

acaricidal,

reticulatum ’ test the Culex eradicant s

a testing

Globitermes

R. insects, ant),

Berkhard Musca

of a

twenty in spp.

(root

holding locus

speratu,

the water

spp.

(for

(lesion

Leaf

knot plant

and of

1st

2012201147 27 Feb 2012 to 5

The The Myzns for the discs Expected expected assessments amount Colby A)*(%

mortality. top.

pots dried

were

persicae equation

mortality

These of

were

from

mortality cotyledons

mortality cut

were

All from were aprayed the

to were of

adjusted tests compare individual

from mixture

stored excised may

transferred were

in included

mixture^ be a

in removed, for

Berkhard

the

partner Chinese attributed

ai a

any

Weiss ’ mortality

s

a from

applied

Synperonic

mortality %

B).

cabbage leaving

Potter

mortality

Room

the to

The

synergism. achieved

alone culture

Tower.

seen at results approximately

16 leaves NP8

20°C of at

in on

mixture the with

control.

Once

are the

This and radish for

same

the set control

3 placed

dry,

is

days

partner

out mixture

cotyledons rate. calculated 20-25 The

ventilated

in

and test

on

Any results

Tables

A

aphids

agar

the and at

+

increase

each in (100%- and

test

in analysed of

lids I-HL

the on

best the

left ratio species

were each following

in

mortality pots. % overnight.

to the

using

mortality leaf placed

that assessed R2 expected

disc.

the way:

on

of

2012201147 27 Feb 2012 I I I Solnosad Emamectin Abam Mixture

actin

benzoate

partnor Ratio

- (gamma: ai ai 4:1 4:1 2:1 2:1 4:1 4:1 4d 2:1 2:1 2:1 2:1 2:i 1:1 1:1 12 12 1:1 in 1:1

aTs) Gamma 1.00 050 0.50 025 050 025 1.00 0.60 0.50 1,00 025 0.50 025 1.00 0.50 025 1.00 0.50 050 1.00 025 Rates Results

appfled

for '

05625

Other (ppm) test 0.13 025 0.13 025 0.06 0.13 025 0.1 025 0.13 0.50 050 0.25 0.60 025 0.50 050 1Ό0 025 1.00

S usiag TABLEI

a)

Heliothb Gamma 46 32 233 44 42 48 32 28 32 28 888 48 46 28 296 32 32 32 26 46 43 32 28 32 32 2B Observed

vtracou OJterai 33 59 44 42 33 88 87 86 87

% 0 0 0 0 0 0 0

mortality Mixture 100 108 100 100 100 100 85 72 63 65 78 89 67 997 99 64 43 29 43 25 43 38 mortality Expected mixture 64 62 68 55 eo 60 52 99 97 98 68 88 98 48 46 32 32 30 28 28

with

%

Observed- expected 25 29 10 11 19 14 18 11 13 1 -3 -3 -3 2 2 2 2 3 1 1 8

I I 2012201147 27 Feb 2012 Lambda-cvtiafathrfn Dhlcrpyrtfos ncfoxacart) Mixture

partner

' Ratio

(pamma: 125:1 1-25:1 1.25:1 25:1 2.6:1 1:1 1:1.6 2:1 2:1 1:20 1:10 120 1:10 12 12 1:10 1X5 1.-03 1:1 1:1 td

.e

afa) Gamma ΟΛΟ 0X0 025 OSO 025 1ΌΟ 1.00 0.50 050 1.00 025 0.50 025 ΟΛΟ 1.00 025 0Λ0 025 0X0 1.00 1.00 Rales

applied

Other (ppm) ΟΛΟ 025 10.00 1.00 0X0 OSO 10X0 025 0.40 020 020 1Ό0 0.40 0X0 ΟΛΟ 020 5X0 2X0 250 5X0 5X0

al Gamma 652 46 46 32 32 32 28 28 46 48 32 32 32 28 28 46 48 236 32 32 28 28 32 Observed Other 50 52 50 48 50 48 48 48 22 22 26 22 26 28 44 29 44 29 36

%

mortality al Mixture 46 32 38 39 35 41 43 71 48 60 44 40 40 40 49 29 63 56 71 49 42 mortality Expected •

mbrturo 74 73 67 66 63 64 61 71 58 63 47 SO 44 47 70 62 52 57 62 54 49

with

%

”

Observed- expected •28 -41 -30 •27 -28 -23 -18 -12 •10 •27 ·13 -3 -3 -7 -4 ■6 -3 -7 -1 0 9

09 1 I ♦ 2012

Feb

27

2012201147 TABLED

Results for test using Spodoptera liltoralii

Expected % Ratos applied (ppm) Observed % mortality Observed· mortality with expected Mixture partner Ratio (oarrima: efa) Gamma Other al Gamma Other al Mixture mbdure Emamecttn benzoate ion 0.025 0.0025 0 0 22 0 22 10:1 0.05 0,005 25 6 61 & 22 10:1 0.1 0Λ1 BO 0 52 80 -a 20:1 0,05 0.0025 25 0 32 25 7 20:1 0-1 0.005 BO e gs 90 -24 5:1 0.025 0.005 0 6 48 6 40 &1 . 0jD5 0.01 25 0 76 25 51 Solnosad 1:10 0.025 0.25 0 0 78 0 .. 79 1:10 0.05 0.5 25 29 98 47 49 1:2.5 0.05 0,125 25 0 59 25 34 1:2.5 0.1 025 90 0 99 . SO 9 Its 0.025 0.125 0 0 34 0 34 irs 0,05 025 25 0 82 25 . 57 83 1-9 0.1 0.5 90 29 ... 7

I « 2012

Feb

27

2012201147 TABLE ΙΠ

Results for test using (Afyzur perslcae)

Hate applied (ppm) Observed % mortality Expected % Observed- mortality with expaoted Mixture partner Ratio (gamma: ata) Gamma Other at Gamma Other Mixture mixture Thiamethcxam 1:10 025 28 70 92 100 B7 3 1:10 08 5 69 94 100 98 2 12.5 05 125 69 70 100 91 9 128 1.0 28 sa 92 100 100 0 15 025 125 70 70 100 91 9 1:5 08 28 69 92 100 97 3 1:5 1.0 6 98 94 100 100 0 Lambda-cyhalothrin 1:1 025 026 70 4 92 71 21 1:1 0.5 06 69 14 86 73 23 12- 025 0.125 70 10 66 73 •7 1Λ 1.0 05 98 14 100 98 2 21 08 0.25 69 4 100 70 so 4:1 05 0.125 69 10 98 72 26 4:1 1.0 025 98 4 too 98 2

I 21 The claims defining the invention are as follows: 2013

1. A mixture of gamma-cyhalothrin and chlorpyrifos, wherein the mixture is substantially free of (7?)-a-cyano-3-phenoxybenzyl (Z)-(15,35)-3-(2-chloro-3,3,3-trifluoroprop-l-enyl)-2,2- Aug

5 dimethylcyclopropanecarboxylate. 15

2. An insecticidal composition comprising gamma-cyhalothrin, chlorpyrifos and one or more insecticidally inert carrier or diluents, wherein the composition is substantially free of (R)-a- cyano-3 -phenoxybenzyl (Z)-( 15,35)-3 -(2-chloro-3,3,3 -trifluoroprop-l-enyl)-2,2- 10 dimethylcyclopropanecarboxylate.

2012201147 3. An insecticidal composition according to claim 2, further comprising one or more surface active agents.

15 4. A method of combatting and controlling insect, acarine or nematode pests at a locus which comprises treating the pests or the locus of the pests with an effective amount of a mixture comprising gamma-cyhalothrin and chlorpyrifos, wherein the mixture is substantially free of (7?)-a-cyano-3 -phenoxybenzyl (Z)-( 15,35)-3 -(2-chloro-3,3,3 -trifluoroprop-l-enyl)-2,2- dimethylcyclopropanecarboxylate. 20 5. A method according to claim 4 wherein the pests are insect pests of growing plants.

6. A mixture according to claim 1, substantially as hereinbefore described, with reference to any of the Examples. 25 7. A composition according to claim 3, substantially as hereinbefore described, with reference to any of the Examples.

8. A method according to claim 4, substantially as hereinbefore described, with reference to any 30 of the Examples.