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NEW ZEALAND CONSUMER MEDICINE INFORMATION VERPAMIL SR Verapamil SR tablets 120mg and 240mg

channel blockers. These medicines Do not take VERPAMIL SR if you What is in this leaflet work by opening up blood vessels, are taking , a medicine causing to fall and used to treat chest pain. This leaflet answers some common allowing more blood and oxygen to questions about VERPAMIL SR. reach the heart. Do not take this medicine after the expiry date printed on the It does not contain all the available Ask your doctor if you have any pack or if the packaging is torn or information. It does not take the questions about why this shows signs of tampering. place of talking to your doctor or medicine has been prescribed for If it has expired or is damaged, pharmacist. you. return it to your pharmacist for Your doctor may have prescribed it disposal. All medicines have risks and for another reason. benefits. Your doctor has weighed If you are not sure whether you the risks of you taking VERPAMIL This medicine is available only with should start taking this medicine, SR against the benefits they expect a doctor’s prescription. talk to your doctor. it will have for you. Before you start to take If you have any concerns about Before you take it taking this medicine, ask your VERPAMIL SR Tell your doctor if you have doctor or pharmacist. to any other medicines, Keep this leaflet with the When you must not take foods, preservatives or dyes. medicine. You may need to read it it again. Tell your doctor if you have or Do not take VERPAMIL SR if you have had any of the following have an to: medical conditions: What VERPAMIL SR  any medicine containing is used for verapamil.  any other heart problems  any of the ingredients listed at  problems the end of this leaflet.  problems VERPAMIL SR is available in two  muscle conditions such as strengths: VERPAMIL SR 120mg Some of the symptoms of an myasthenia gravis, Lambert- and VERPAMIL SR 240mg. allergic reaction may include: Eaton syndrome or advanced ; wheezing or Duchenne’s muscular dystrophy The letters SR in the name difficulty breathing; swelling of the VERPAMIL SR stand for “sustained face, lips, tongue or other parts of Tell your doctor if you are release”. This means the medicine the body; , itching or hives on pregnant or plan to become is released into the blood over an the skin pregnant. extended period of time, usually VERPAMIL SR may affect your allowing the medicine to be taken Do not give this medicine to a developing baby if you take it during once a day. child. Safety and effectiveness in . Your doctor can discuss children have not been established. with you the risks and benefits VERPAMIL SR is used to treat involved. Do not take VERPAMIL SR if you  High blood pressure have certain other heart Tell your doctor if you are breast- () conditions such as , feeding or plan to breast-feed.  Heart and chest pain a very slow , some The active ingredient in VERPAMIL brought on, for example, by types of or a disease SR passes into breast milk. Your exercise or stress (known of the heart muscle. doctor can discuss with you the as pectoris) risks and benefits involved.  Long-term prevention of Do not take VERPAMIL SR if you future heart attacks have low blood pressure, known If you have not told your doctor as . about any of the above, tell Your VERPAMIL SR tablets contain him/her before you start taking verapamil. It belongs to a group of VERPAMIL SR. medicines known as calcium

Page 1 of 4 Taking other medicines  Antiviral medicines such as (angina), doses will generally be ritonavir, used to treat HIV 120mg to 480mg VERPAMIL SR Tell your doctor or pharmacist if infections daily in 1 or 2 divided doses. The average daily dose is 360mg. you are taking any other  and sulfinpyrazone, medicines, including any that you medicines used to treat and For all conditions, it is advised any get without a prescription from prevent gout your pharmacy, supermarket or single dose should not exceed  Doxorubicin, a medicine used to 240mg. health food shop. treat certain cancers Some medicines and VERPAMIL  , a medicine used to SR may interfere with each other. VERPAMIL SR is not intended for treat use in children. These include:  St. John’s Wort, a product used to elevate mood Do not halve VERPAMIL SR  Other medicines for high blood tablets. pressure, such as beta blockers, These medicines may be affected ACE inhibitors and vasodilators by VERPAMIL SR or may affect When switching from immediate Alpha-blockers such as prazosin  how well it works. You may need release verapamil to VERPAMIL and terazosin, used to treat high different amounts of your SR, the total daily dose in blood pressure and enlarged medicines, or you may need to take milligrams may remain the same. prostates (BPH) different medicines.  Fluid tablets, also called diuretics Your doctor and pharmacist have How to take it  or , medicines more information on medicines to Swallow the tablets whole with a used to treat heart failure be careful with or avoid while taking full glass of water.  , a medicine used this medicine. to treat diabetes When to take it  Medicines used to treat irregular heart beat (eg. , How to take Take your medicine at about the , , same time each day. and ) VERPAMIL SR Taking it at the same time each day  Cimetidine, a medicine will have the best effect. It will also commonly used to treat reflux Follow all directions given to you help you remember when to take it. and ulcers by your doctor or pharmacist  , a medicine used to carefully. VERPAMIL SR should be taken treat depression They may differ from the information regularly, preferably with or shortly  Lithium, a medicine used to treat contained in this leaflet. after meals with some liquid. mood swings and some types of depression If you do not understand the How long to take it  Cyclosporin, everolimus, instructions on the bottle, ask sirolimus and tacrolimus, your doctor or pharmacist for VERPAMIL SR is usually taken as medicines used to prevent organ help. long-term treatment. Keep taking transplant rejection or to treat VERPAMIL SR for as long as your certain problems with the How much to take doctor recommends. immune system  , and Adults: If you forget to take it telithromycin, antibiotic For high blood pressure If it is almost time for your next medicines (hypertension), the usual dose in dose, skip the dose you missed  , phenobarbitone adults is one VERPAMIL SR 240mg and take your next dose when and , medicines tablet daily. you are meant to. commonly used to treat epilepsy  Rifampicin, an antibiotic used in For elderly patients and patients Otherwise, take it as soon as you conditions such as tuberculosis new to verapamil therapy, an initial remember, and then go back to (TB) daily dose of VERPAMIL SR 120mg taking your medicine as you  Theophylline, a medicine used to daily may be appropriate. would normally. treat asthma  Midazolam, a medicine used to The maximum dose is one Do not take a double dose to treat sleeping problems VERPAMIL SR 240mg tablet twice make up for the dose that you (insomnia) daily. missed.  Buspirone, a medicine used to This may increase the chance of treat anxiety For prevention of future heart you getting an unwanted side effect.  lowering medicines attacks, the usual dose in adults is such as , lovastatin between 240mg to 480mg If you are not sure what to do, and VERPAMIL SR daily in 1 or 2 ask your doctor or pharmacist.  , or other divided doses. The average daily medicines which affect the dose is 360mg. If you have trouble remembering to clotting of your blood take your medicine, ask your For prevention of chest pains pharmacist for some hints. Page 2 of 4 If you take too much Do not give your medicine to You may not experience any of anyone else, even if they have them. (overdose) the same condition as you. Immediately telephone your Ask your doctor or pharmacist to doctor or the National Poisons Do not stop taking your medicine answer any questions you may Information Centre (0800 POISON or lower the dosage without have. or 0800 764 766) for advice, or go checking with your doctor. to Accident and Emergency at Tell your doctor or pharmacist if the nearest hospital, if you think Things to be careful of you notice any of the following that you or anyone else may have and they worry you: taken too much VERPAMIL SR. Grapefruit juice should be  , light-headedness, Do this even if there are no signs avoided while taking VERPAMIL tiredness of discomfort or poisoning. You SR.  may need urgent medical attention. Grapefruit juice contains one or more components that alter the  Symptoms of an overdose may metabolism of some medicines,  Feeling sick, upset stomach, include feeling faint, light- including VERPAMIL SR. vomiting headedness, dizziness or chest  pain. Be careful driving or operating  Ringing ears machinery until you know how  Hair loss VERPAMIL SR affects you.  An increase in the amount you While you are taking This medicine may cause tiredness, sweat dizziness or light-headedness in  Joint or muscle pain VERPAMIL SR some people. If you have any of these symptoms, do not drive, Tell your doctor as soon as Things you must do operate machinery or do anything possible if you notice any of the else that could be dangerous. following: If you are about to be started on any new medicine, remind your Be careful when drinking  Chest pain, fainting, collapse doctor and pharmacist that you while you are taking this  Slow, fast or irregular heart beat are taking VERPAMIL SR. medicine.  Shortness of breath, together If you drink alcohol, dizziness or with swelling of the feet or legs Tell any other doctors, dentists, light-headedness may be worse. due to fluid build up and pharmacists who treat you  Fever, upper stomach pain, that you are taking this medicine. If you feel light-headed, dizzy or feeling generally unwell faint when getting out of bed or  Skin rash, itching or flaking skin If you are going to have surgery, standing up, get up slowly.  Severe blisters and bleeding in tell the surgeon or anaesthetist Standing up slowly, especially when the lips, eyes, mouth, nose and that you are taking this medicine. you get up from bed or chairs, will genitals It may affect other medicines used help your body get used to the during surgery. change in position and blood These side effects are usually rare pressure. If this problem continues but can be serious and need urgent If you become pregnant while or gets worse, talk to your doctor. medical attention. taking this medicine, tell your doctor immediately. The list of side effects mentioned Side effects above is not complete. If you If you are about to have any should suffer from any of these side blood tests, tell your doctor that Tell your doctor or pharmacist as effects or any other undesired effect you are taking this medicine. soon as possible if you do not please tell your doctor or It may interfere with the results of feel well while you are taking pharmacist. some tests. VERPAMIL SR. This medicine helps most people Keep all of your doctor’s with high blood pressure or heart After taking appointments so that your and chest pain but it may have VERPAMIL SR progress can be checked. unwanted side effects in a few Your doctor may ask you to have people. All medicines can have side blood tests from time to time. effects. Sometimes they are Storage serious, most of the time they are Keep your tablets in the bottle not. You may need medical Things you must not do until it is time to take them. attention if you get some of the side If you take the tablets out of the Do not take VERPAMIL SR to effects. treat any other complaints unless bottle they may not keep well. your doctor tells you to. Do not be alarmed by the Keep your tablets in a cool dry following lists of side effects. place where the temperature stays below 25°C.

Page 3 of 4 Do not store VERPAMIL SR or any  Titanium dioxide (Film coat) other medicine in the bathroom or  Talc (Film coat) near a sink. Do not leave it on a  Macrogol (Film coat) window sill or in the car.  D&C yellow #10 aluminium Heat and dampness can destroy lake (Film coat) some medicines.  Brilliant blue FCF aluminium lake (Film coat) Keep it where children cannot  Sunset yellow FCF reach it. aluminium lake [E110] A locked cupboard at least one-and- (Film coat). a half metres above the ground is a good place to store medicines. VERPAMIL SR 240mg tablets are gluten free and lactose free. Disposal If your doctor tells you to stop If you want to know taking this medicine or the expiry date has passed, ask your more pharmacist what to do with any Should you have any questions medicine that is left over. regarding this product, please contact your pharmacist or doctor. Product description Who supplies this medicine What it looks like Distributed in New Zealand by: VERPAMIL SR 120mg tablets are white film coated, round tablets. Mylan New Zealand Ltd, PO Box 11183, VERPAMIL SR 240mg tablets are Ellerslie, Auckland. light green film coated, capsule shaped tablets. Telephone: (09) 579 2792

Ingredients Date of Information 02 July 2020 (Based on datasheet VERPAMIL SR tablets contain the dated 02 July 2020) active ingredient, verapamil hydrochloride.

Each VERPAMIL SR 120mg tablet also contains:  stearate  Hydrogenated castor oil  Purified talc  Lactose  Methacrylic acid copolymer  Hypromellose (Film coat)  Diethyl phthalate (Film Coat).

The tablets are polished with carnauba wax.

VERPAMIL SR 120mg tablets are gluten free.

Each VERPAMIL SR 240mg tablet also contains:  Magnesium stearate  Sodium alginate  Povidone  Microcrystalline cellulose  Purified talc  Polyvinyl alcohol (Film coat) Page 4 of 4