Experiment of Exp11.His100 Digestive Glands

｝ Salivary glands

Liver Gallbladder Pancreas

林谷峻 生物及解剖學科 A. Major salivary glands – S 55 Composite 1. Parotid gland a. Stroma – capsule - septa - lobes - lobules; lymphocytes, plasma cells, adipocytes b. Parenchyma – totally serous (1) Serous acinus – lumen, serous acinar and myoepithelial cells, and basal lamina Serous cell – apical surface - zymogen granules – basal surface - chromidial substances (rER + free ribosomes) (2) Ducts – Intralobule - intercalated ducts (low cuboidal, have myoepithelial cells) - striated ducts (cuboidal  columnar) – Interlobule - excretory ducts (pseudostratified columnar - basal cell) ( stratified cuboidal  stratified columnar  stratified squamous) 2. Submandibular (submaxillary) gland – Mixed gland - mostly serous, few mucous acini, serous demilunes & ducts (ditto) mucous cell - mucinogen granules, flattened nucleus 3. Sublingual gland – Mixed gland - mostly mucous, serous demilunes Striated duct Intralobular – Ducts - intercalated , intralobular, and excretory ducts duct Slide 55 Parotid gland (under LM - left) – totally serous acini, intercalated, striated, and excretory ducts

Serous acini Excretory duct

c.s. Intercalated duct l.s. Septa Lobule

Lobule Striated ducts Slide 55 Parotid gland – Pure serous gland – serous acini (- serous cells), intercalated duct - myoepithelial cells

c.s.

Lumen

Serous acini Plasma cell Intercalated ducts (myoepithelial cell) l.s.

Striated duct (striation) Slide 55 Submandibular gland (under LM - middle) – mixed gland - mostly serous, few mucous acini, serous demilunes Serous acinus

Striated ducts Lobule

Septa

Mucous acini Lobule (mucinogen gr.) Excretory duct Intercalated duct Serous demilune Lumen Slide 55 Sublingual gland (under LM - right) – Mixed gland - mostly mucous, few serous acini, serous demilunes Intralobular duct Lobule Intralobular duct

Septa Serous demilune

Mucous acini Mucous acinus (mucinogen gr.) Excretory ducts Intercalated duct Myoepithelial cell Excretory duct B. Pancreas – Slide 1 Cat, Slide 56 – S 57 Ampulla of Vater (with duodenum), Monkey, c.s. 1. Exocrine gland a. Stroma – capsule - septa - lobules b. Parenchyma (1) Serous acini – serous acinar cell – zymogen granules, ergastoplasm (chromidial substances) (2) Ducts – intercalated duct (squamous) - centroacinar cell – intralobular duct (cuboidal) – interlobular duct (columnar) – main pancreatic duct (of Wirsung) (high columnar)

2. Endocrine gland – islets of Langerhans (epithelioid tissues) - cords or clumps of cells, capillaries Slide 56 Pancreas

Interlobular duct

Islets of Langerhans

Septa

Lobules

Large interlobular duct Slide 56 Pancreas Centroacinar cells

Intercalated ductl.s. c.s.

Intercalated ducts Serous acini

Islets of Langerhans Slide 1 Pancreas, Cat Intercalated duct Acinus Islets of Langerhans Ergastoplasm Ergastoplasm Septa Capillaries - RBC Capillary - RBC Zymogen granules

Zymogen Lobules granules

Islets of Langerhans IntralobularSerous ducts acinus Slide 57 Ampulla of Vater and duodenum, Monkey, c.s.

Duodenum Duodenum

Common Ampulla of Vater bile duct

Pancreatic duct

Ampulla of Vater (Sphincter of Oddi) DuodenumSphincter of Oddi papilla Duodenal gland C. Liver – Slide 58, Demo 58-1 Pig – Slide 59 Phagocytosis, Rabbit – Slide 60 Bile canaliculi 1. Visceral peritoneum – Glisson’s capsule - lobules (interlobular septa, Pig) 2. Classic hepatic lobule: – central vein - endothelial cells, few CT – sinusoid - endothelial cells and Kupffer cells - carbon particles – hepatocytes - hepatic cell plates, some binucleate; bile canaliculi – portal canal (area) - portal triad - portal vein, hepatic artery, and bile duct (cuboidal) - lymphatics, nerves, CT – space of Mall, limiting plate of hepatic cells Slide 58 Liver Classic hepatic lobule Classic hepatic lobule Portal canal Pig liver Human liver

Central vein

Glisson’s capsule Slide 58 Liver Portal canal – portal triad – portal vein, hepatic artery, bile duct – lymphatics, nerves, CT Space of Mall

Lymphatics Bile duct CT Hepatic Lymphatics artery Portal vein Sinusoid Limiting plate of Hepatic hepatocytes cell plate Slide 58 Liver

Binucleate of hepatocyte CT

Endothelial cell

Central vein

Kupffer cells

Sinusoid Demo 58-1 Liver, pig Interlobular septum Classic hepatic lobules

Portal canal Central vein

Glisson’s capsule

Visceral Interlobular septa peritoneum - mesothelium

Visceral peritoneum - Glisson’s capsule Slide 59 Liver, phagocytosis, rabbit

Central vein Endothelial cell

Sinusoids

Binucleate of hepatocytes Kupffer cells Slide 60 Liver, bile canaliculi

Biliary system Limiting plate D. Gallbladder – Slide 61

Adventitia

or adventitia Slide 61 Gallbladder

Folds Columnar epi Striated border

Adipose Mucosa tissue - folds Muscularis externa

Adventitia

Lamina propria TheThe EndEnd