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Mechanisms, Methods & Clinical Utilization Room Plenary Hall 09:05-10:20 Organizers: Peter A Monday AM Opening Session Room Plenary Hall 07:30-08:20 Chair: Georg Bongartz, ISMRM President 07:30 Welcome & Award Presentations. 2011 Mansfield Lecture Room Plenary Hall 08:20-09:05 Chair: Georg Bongartz, ISMRM President 08:20 Challenges in fMRI Seiji Ogawa, Ph.D. Tohoku Fukushi University, Sendai, Japan Plenary Lectures Functional Brain Networks at "Rest": Mechanisms, Methods & Clinical Utilization Room Plenary Hall 09:05-10:20 Organizers: Peter A. Bandettini & Mark J. Lowe 09:05 1. What is the Physiological Basis of Functional Connectivity & What Can It Tell Us? Maurizio Corbetta Washington University School of Medicine, St. Louis, MO, USA Spontaneous or intrinsic, i.e. not stimulus- or task-driven, activity in the brain is not noise, but orderly and organized at the level of large scale systems in a series of functional networks that maintain at all times a high level of coherence. Understanding this distributed spatio- temporal structure is critical for understanding neuronal communication and behavior. 09:30 2. Resting-State Signals: Identification, Classification & Relation to Brain Connectivity Stephen M. Smith Oxford University FMRIB Centre, Oxford, England, UK Cardiovascular MRI technology continues to evolve in terms of its ability to rapidly and reliably produce accurate, functional, diagnostic information, and also in its capacity to provide quantitative results. a number of centers are beginning to explore the use of MRI as a means to triage patients presenting in the emergency room with acute chest pain. This presentation will explore the latest advances in cardiovascular MRI methods that are especially applicable to the diagnosis of Acute Coronary Syndrome (ACS). 09:55 3. Resting Functional Connectivity: Potential as a Clinical Marker in Individual Patients Michael D. Greicius Stanford University Medical Center, Stanford, CA, USA Functional MRI currently has few clinical applications. This is due, in part, to the difficulty of using task-activation fMRI in a clinical setting. Resting-state fMRI, which allows for the detection of 15-20 large-scale brain networks, has the potential to overcome some of these clinical limitations. This talk will examine efforts to develop resting-state fMRI biomarkers for several neuropsychiatric disorders including coma, depression and chronic pain. Particular emphasis will be placed on resting-state fMRI as a potential biomarker in Alzheimer’s disease. Clinical Intensive Course (Admission limited to Clinical Course registrants only) Hip Bone & Soft Tissue Pathology: Case-Based Teaching Room 516A-C 08:30-09:45 Moderator: Mark Schweitzer 08:30 Soft Tissue Pathology About the Hip Miriam A. Bredella 09:10 Osseous Pathology About the Hip Mark Schweitzer 1 Monday AM Clinical Intensive Course (Admission limited to Clinical Course registrants only) Oncologic Body Imaging Room 510 08:30-10:15 08:30 Tumor Response Assessment using CT & MRI: Current Clinical Practice Frank H. Miller 09:00 Tumor Response Assessment using the Advanced MRI Methods Dow-Mu Koh 09:30 Whole Body DWI: Does It Have a Role in Oncology? Taro Takahara 10:00 Discussion Clinical Intensive Course MR Imaging in Brain Tumors - ISMRM/ASNR Joint Session Room 510 11:00-13:00 Moderators: Meng Law & Brian D. Ross 11:00 Cerebral Blood Flow & Permeability in Brain Tumors Meng Law 11:25 Diffusion in Brain Tumors Danielle van Westen 11:50 MR Biomakers in Brain Tumor Thomas L. Chenevert 12:15 Pseudoprogression, Recurrence & Radiation Necrosis Pia C. Maly Sundgren 12:45 Discussion Clinical Intensive Course Clinical Protocol Challenges in MSK Room 516A-C 11:00-13:00 Moderator: Garry E. Gold 11:00 High Field (3T & 7T) Garry E. Gold 11:40 Reducing Metallic Susceptibility Hollis G. Potter 12:20 Pediatric Jerry R. Dwek High Resolution Brain Imaging Room 511A-C 11:00-13:00 Moderators: Fernando Calamante & Timothy Q. Duong 11:00 4. Using In-Vivo MRI to Study Learning Induced Brain Plasticity in Adult Mice Trained on a Spatial Maze Jurgen Germann1, D. Vousden1, P Steadman1, J. Dazai1, C. Laliberte1, S. Spring1, L. Cahill1, R. M. Henkelman1, Jason P. Lerch1 1The Mouse Imaging Centre, the Hospital for Sick Children, Toronto, Ontario, Canada 2 Monday AM 11:12 5. Can Preexisting Differences in Neuroanatomy Predict Training Performance? An In-Vivo MRI study of Adult Mice Trained on a Spatial Maze Jurgen Germann1, P. Steadman1, D. Vousden1, J. Dazai1, S. Spring1, C. Laliberte1, L. Cahill1, R. M. Henkelman1, J. P. Lerch1 1The Mouse Imaging Centre, the Hospital for Sick Children, Toronto, Ontario, Canada 11:24 6. Super-Resolution Track-Density Imaging Studies of Mouse Brain: Comparison to Histology Fernando Calamante1,2, Jacques-Donald Tournier1,2, Nyoman D. Kurniawan3, Zhengyi Yang3, Erika Gyengesi4, Graham J. Galloway3, David C. Reutens3, Alan Connelly1,2 1Brain Research Institute, Florey Neuroscience Institutes, Heidelberg West, Victoria, Australia; 2Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia; 3Centre for Advanced Imaging, the University of Queensland, Brisbane, Queensland, Australia; 4Neuroscience Research Australia, Randwick, New South Wales, Australia 11:36 7. Ultra-High Resolution Functional MRI & Electrophysiology of the Rat Primary Somatosensory Cortex Yen-Yu Ian Shih1, You-Yin Chen2, Hsin-Yi Lai2, Timothy Q. Duong1 1Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA; 2Institute of Biomedical Engineering, National Yang-Ming University, Taipei, Taiwan 11:48 8. Magnetic Resonance Microscopy of Human α-Motor Neurons & Neural Processes Jeremy Joseph Flint1,2, Brian Hansen3, Sharon Portnoy1,2, Choong H. Lee2,4, Michael A. King5, Michael Fey6, Franck Vincent6, Peter Vestergaard-Poulsen3, Stephen J. Blackband2,7 1Neuroscience, University of Florida, Gainesville, Fl, USA; 2McKnight Brain Institute, University of Florida, Gainesville, Fl, USA; 3Center for Functionally Integrative Neuroscience, University of Aarhus, Aarhus, Denmark; 4Electrical Engineering, University of Florida, Gainesville, Fl, USA; 5Pharmacology & Therapeutics, University of Florida, Gainesville, Fl, USA; 6Bruker Biospin; 7National High Magnetic Field Laboratory, Talahassee, Fl, USA 12:00 9. Evidence Towards Columnar Organization of Human Area MT with Sub-Millimetric, 3D, T2 weighted BOLD fMRI at 7 Tesla Federico De Martino1, Jan Zimmermann1, Gregor Adriany2, Pierre-Francois van de Moortele2, David A. Feinberg3, Kamil Ugurbil2, Rainer Goebel1, Essa Yacoub2 1Cognitive Neuroscience, Maastricht University, Maastricht, Netherlands; 2CMRR, Radiology, University of Minnesota, Minneapolis, MN, USA; 3Advanced MRI Technologies, Sebastopol, CA, USA 12:12 10. Within Digit Somatotopy of the Human Somatosensory Cortex using fMRI at 7T Rosa M. Sanchez Panchuelo1, Julien Besle2, Richard Bowtell3, Denis Schluppeck2, Susan Francis3 1Sir Peter Mansfield Magnetic Resonance Centre , University of Nottingham, Nottingham, United Kingdom; 2School of Psychology, University of Nottingham, Nottingham, United Kingdom; 3Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, Nottingham, United Kingdom 12:24 11. Fast High Resolution Whole Brain T2* Weighted Imaging using Echo Planar Imaging at 7T Jaco J. M. Zwanenburg1, 2, Maarten J. Versluis3, Peter R. Luijten1, Natalia Petridou1, 4 1Radiology, Universiy Medical Center Utrecht, Utrecht, Netherlands; 2Image Sciences Institute, Universiy Medical Center Utrecht, Utrecht, Netherlands; 3Radiology, Leiden University Medical Center, Leiden, Netherlands; 4Rudolf Magnus Institute, University Medical Center Utrecht, Utrecht, Netherlands 12:36 12. Investigation of Magnetic Susceptibility Contrast Across Cortical Grey Matter & White Matter Masaki Fukunaga1,2, Peter van Gelderen1, Jongho Lee1, Tie-Qiang Li1, Jacco A. de Zwart1, Hellmut Merkle1, Kant M. Matsuda3, Eiji Matsuura4, Jeff H. Duyn1 1Advanced MRI section, LFMI, NINDS, National Institutes of Health, Bethesda, MD, USA; 2Biofunctional Imaging, Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan; 3Laboratory of Pathology, NCI, National Institutes of Health, Bethesda, MD, USA; 4Laboratory of Neuroimmunology, NINDS, National Institutes of Health, Bethesda, MD, USA 12:48 13. Exploring Orientation Dependence of T2* in White Matter by Extreme Rotation of the Human Head at 7 Tesla Graham Wiggins1, Chris Wiggins2, Bei Zhang1, Ryan Brown1, Bernd Stoeckel3, Daniel K. Sodickson1 1Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY10016, USA; 2CEA/NeuroSpin, Saclay, France; 3Siemens Medical Solutions USA Inc, New York, NY, USA 3 Monday AM Experimental Myocardial Imaging & Spectroscopy Room 511D-F 11:00-13:00 Moderators: David Sosnovik & Gustav J. Strijkers 11:00 14. Introduction Frederick H. Epstein 11:12 15. Regional Quantification of Myocardial Stiffness using MR Elastography Arunark Kolipaka1, Kiaran McGee1, Shivani Aggarwal1, Qingshan Chen1, Nandan Anavekar1, Armando Manduca1, Richard Ehman1, Philip Araoz1 1Mayo Clinic, Rochester, MN, USA 11:24 16. Embryonic Cardiomyocytes Improve Contractility & Viability of Ischemic Myocardium Leonie E. Paulis1, Alexandra Klein2, Tessa Geelen1, Bernd Fleischmann2, Wilhelm Roell2, Klaas Nicolay1, Gustav J. Strijkers1 1Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands; 2Institute for Physiology, Life & Brain Centre, University of Bonn, Bonn, Germany 11:36 17. Beyond Qualitative Tractography: A Novel & Reproducible Technique for the
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