March 14, 2014 Joann Taie Executive Director Organization for Human

Home , David Linden, Golden Brain Award, Kenneth Kwong, Seiji Ogawa

Vermont Center for Children, Youth, & Families James J. Hudziak, M.D., Director Professor of Psychiatry, Medicine and Pediatrics PHONE (802) 656-1084 FAX (802) 847-7998 Email: [email protected]

March 14, 2014

JoAnn Taie Executive Director Organization for Human Brain Mapping (OHBM)Organization for Human Brain Mapping Glass Brain Award

REGARDING: Nomination of Dr. Alan Evans for The Glass Brain Award

Dear Selection Committee:

It is a true honor to write a letter of support for Dr. Alan Evan’s nomination for the OHBM Glass Brain Award. I understand it is the special intention of the committee to award special scholars who have contributed to the mission of OHBM, who have made extraordinary contributions to the field of human brain mapping, is over 40, and will be in Hamburg (This nominee will be). I can think of no scholar more deserving for the Glass Brain Award than Professor Alan Evans.

A review of his qualifications for this award is very time consuming. I apologize for the long letter. Dr. Evan’s has contributed mightily in both the technical and tactical arenas of human brain mapping, particularly in the areas of understanding the etiopathology and treatment of a wide variety of brain disorders. I will do my best to do justice to his accomplishments but suffice it to say that in my mind Dr. Evan’s is the single most important brain scientist in the world. Now let me try to defend that statement.

First a review of Professor Evan’s CV is breathtaking. His over 450 peer-reviewed publications in the very best journals in the world is a good place to start. The fact that his work has been referenced over 43,000 times provides substrate for the generalizability of his work. His h-index of over 104 puts him in the top 1% of 1% of all research scholars.

Moving to a more microscopic review of his career contributions. The study of brain science remains a relatively young field. Prior to understanding what is abnormal, what is disease and illness, requires an understanding of what is normal and what is well. Dr. Evans and his extended team have contributed to advancing the technical aspects of human brain mapping via image acquisition and analyses (more on this later). Without his technical contributions I doubt the field of neuroimaging would be where it is today. Next, Dr. Evans has contributed to a better understanding of normal. In fact, he has published high science on the senses of sight, smell, hearing, taste, pleasure, self perception, gender, IQ, normal development from birth to old age, appreciation of music, pitch both perfect and otherwise, and consciousness. I would argue that this work was essential to understand etiopathology.

Professor Evan’s has set the standard in the study of disease as well. He has published on an exhaustive array of papers on disorder based human brain mapping. To list a few, epilepsy, stroke, MS, Alzheimers disease, Parkinson’s disease, tumors of the brain, pain, general memory disorders, Huntingtons disease, Fragile X, Fetal Alcohol Syndrome, schizophrenia, depression, alcoholism, psychosis, and Autism Spectrum Disorder. Each of these investigations have directly led to additional research science not only at the understanding of the evolution of disease, but also in the development of new treatment approaches.

Professor Evan’s also has published extensively in the use of brain mapping in the treatment literature. He is

1 1 involved in understanding the brain science of drug treatment, drug development, neurosurgery, transcranial magnetic stimulation, and epigenetic effects of environmental mediation. In short, Professor Evan’s body of work includes developing the technical approaches to the study of the brain, the study of normal brain development, the understanding of etiopathology, and treatment.

Given all of these achievements one would think that Dr. Evan’s would be satisfied with what he has already accomplished, and nothing could be further from the truth. Dr. Evan’s has been prescient in his understanding that to truly understand the human brain, development, illness, resilience and recovery, the field will need massive data sets and big data approaches to dealing with these data. His internationally renowned work on the “Big Brain” has not only drawn a great deal of attention to the important of brain science, it has also changed the way in which medical schools and graduate schools around the world teach neuroanatomy. He not only shares his discoveries, it is in his DNA. His creation of CBRAIN, LORAS, and CIVIT and his international reputation for sharing his big data pipelines has allowed many of us the possibility to investigate brain based disorders on sample sizes far larger than we ever dreamed. He continues to push the envelope in creating larger, collaborative, sharing scientific communities all aimed at one greater good, the discovery and treatment of brain-based disorders. He is rare in the characteristic of being a creative selfless genius.

Finally, Professor Evan’s strongly supports the mission of OHBM. In fact it was his encouragement that led to my teams from both the US and Europe to attend, submit science to, and present at OHBM. Professor Evan’s is an ideal candidate for the Glass Brain Award. It will be a joy to follow the next stages of this exceptional man’s terrific career.

Sincerely,

James J. Hudziak, M.D. Professor, Psychiatry, Medicine & Pediatrics Director, Vermont Center for Children Youth & Families Thomas M. Achenbach Chair in Developmental Psychopathology UVM College of Medicine Visiting Professor, Sophia Children’s Hospital, ErasmusMC, Rotterdam Adjunct Professor (Child) Psychiatry, Washington University, St. Louis Adjunct Professor (Child) Psychiatry, Dartmouth, Hanover

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Curriculum Vitae ALAN EVANS PhD James McGill Professor of Neurology/Neurosurgery, Psychiatry, Biomedical Engineering Montreal Neurological Institute, McGill University Founder, Biospective Inc.

NAME EVANS Alan Charles BIRTHDATE October 7th, 1952 BIRTHPLACE Barry, Wales, U.K. CITIZENSHIP British ; Canadian ADDRESS 2056 Grey Ave., MONTREAL H4A 3N4, Quebec FAMILY Married (Karen) ; three children (Catherine, Meaghan, Leigh) TELEPHONE Work: 514-398-8926 ; Cell: 514-984-6919 ; Home: 514-487-6365

ACADEMIC TRAINING 1971-1974: B.Sc. 1st Class Honours, Physics, Liverpool University B.Sc. General Mathematics, Liverpool University 1974-1975: M.Sc. Medical Physics, Surrey University Thesis: “ Negative Pions in Radiotherapy " 1975-1978: Ph.D. Biophysics, Leeds University Thesis: “ The development and application of an interactive computer graphics system in the study of protein structure "

CAREER EXPERIENCE AND RESEARCH INTERESTS 1978-1979: Post-doctoral Fellow: Dept. of Biophysics, Leeds University Development of an interactive computer graphics system for 3-D protein structural studies. 1979-1984: Physicist: PET program, Atomic Energy of Canada Ltd. Research and development of physics, reconstruction, physiological kinetics and software aspects of Therascan 3128 PET scanner. 1984-1990: Assistant Professor, Dept. of Neurology/Neurosurgery, McGill U. 1988-1990: Assistant Professor, Medical Physics Unit, McGill U. 1988-1994: Co-director, NeuroImaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute (MNI) 3-D computerized brain atlas ; 3-D MRI/PET image correlation 1989-1994: Head, Tomograph Facility, Positron Imaging Laboratories, McConnell Brain Imaging Centre, MNI 1990-1995: Associate Prof., Dept. of Neurology/Neurosurgery, Dept. of Biomedical Engineering, Medical Physics Unit, McGill U. 1993-1994: Acting Coordinator, McConnell Brain Imaging Centre, MNI 1994-1999: Coordinator, Positron Imaging Laboratories, MNI Coordinator, McConnell Brain Imaging Centre, MNI 1995-present: Professor, Dept. of Neurology/Neurosurgery, Dept. of Biomedical Engineering, Medical Physics Unit, McGill U. Associate Member., Dept. of Electrical Engineering, McGill U. 2000-present: Director, Montreal Consortium for Brain Imaging Research 2000-present Founder, Biospective Inc (http://www.biospective.com)

RESEARCH STATISTICS (as of August 2013) h-index: 104

3 3 Citations: 42,479 Peer-reviewed journal publications: 445

4 4 GRANT SUPPORT Past operating/equipment/maintenance/equipment Grants:

Canadian Medical Research Council: AM Hakim, AC Evans and CJ Thompson “ New Generation Positron Emission Tomograph" $ 1,000,000 major equipment grant - 1987

Philips Medical Systems: AC Evans and TM Peters “ Pegasus project - Evaluation of 3-D imaging workstation " $ 175,000 US major equipment grant - 1988

Canadian Medical Research Council Special Project Grant SP-30: AC Evans and E Meyer “ Positron Imaging of Neural Systems - Methodology " $333,810 p.a. for five years 1993 + 255,049 equipment

Canadian Medical Research Council: “ The functional neuroanatomy of cognitive processes studied by positron emission tomography " D Bub, AC Evans, H Chertkow $ 75,500 p.a. for 3 years, 1991-94

McDonnell-Pew Program in Cognitive Neuroscience: B Milner, M Petrides, B. Alivisatos, D Bub, AC Evans, A Gjedde, E Meyer, A Olivier, D Pandya, L Petito, M Seidenberg, R Zatorre “ Proposal to establish a cognitive neuroscience center at the Montreal Neurological Institute " $300,000 p.a. for five years, 1990-95

Canadian Medical Research Council Maintenance Grant: AC Evans and TM Peters “ Three-dimensional NeuroImaging " $ 70,375 p.a. for 3 years 1992-1995 + $64,697 equipment

Canadian MRC Operating Grant TM Peters, AC Evans, A Olivier “ Imaging for frameless stereotaxy" $ 76,700 p.a. for three years 1992-95

Canadian MRC Equipment Grant TM Peters, AC Evans, A Olivier “ 3-D imaging for neurosurgery" $ 98,114 for one year 1992-93

Dr. Hector Ma, Hong Kong AC Evans “ Imaging of cognitive processing using functional MRI" $20,000 p.a. for one year 1994-1995

National Institutes of Mental Health (NIMH) AC Evans “ Distribution of M.N.I. MRI-base brain atlas" $ 25,000 p.a. for one year 1993-1994

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Canadian MRC University-Industry Operating Grant TM Peters, AC Evans, ISG Inc “ Model-based segmentation of tomographic data" $ 30,000 p.a. for 3 years 1992-1995 + $75,000 equipment

Human Frontier Science Projects Organization (HFSPO) AC Evans “ Multi-center collaboration on functional MRI studies of human cognition: MNI Component" Overall Program PI: J Belliveau (Harvard) $ 25,000 p.a. for three years 1993-1996

Canadian MRC-SSHRC Inter-council grant AC Evans and TM Peters “Neuroimaging of familial language impairment" $53,000 p.a. (averaged) for three years 1993-1996 Neuroimaging section of a multi-disciplinary collaboration investigating a genetic basis for specific language impairment. Overall Program Coordinator: M. Gopnik Overall Program Budget: $ 300,000 p.a. for 3 years 1993-1996

Human Brain Map Project: AC Evans, T Paus, B Pike, M Petrides, KJ Worsley “Neuroanatomical segmentation" $ 300,000 p.a. for five years 1993-2003 MNI component of a multi-center collaboration to construct a digital reference system for the human brain. Overall Consortium PI: J Mazziotta (UCLA) Overall Consortium Award: $ 1.3M p.a. for ten years 1993-2003

Clinical Trial Contract - AutoImmune AC Evans, DL Arnold, G Francis, J Antel “ Longitudinal MRI evaluation of orally-administered bovine myelin as a therapy for multiple sclerosis” $US 1,400,000 over four years 1994-1998

Canadian NSERC Collaborative Project Grant KJ Worsley and AC Evans “ Statistical analysis of PET and MRI images" $ 42,000 p.a. for 3 years 1995-1998

MRC Group Grant AC Evans and colleagues “ The physiology and pathophysiology of neuronal activation” $625,000 p.a. over three years 1998-2001 + $88,588 equipment

London Life Award T Owens, J Antel, Evans AC “ The role of microglia in chronic progressive multiple sclerosis” $100,000 p.a. over three years 1996-99

Clinical Trial Contract - Novartis AC Evans, P Bourgouin, G Francis

6 6 “ Phase II clinical trial of CGP 77716 treatment for multiple sclerosis: MRI evaluation” $US 270,000 p.a. over two years 1997-99

Human Brain Project, Phase II DL Collins and AC Evans MNI component of a multi-center P20 application DA Rottenberg, JL Stern, DL Collins, AC Evans, C Davatzikos D Shen, Z Lao, EH Herscovits “Spatial and temporal patterns of functional activation” McGill sub-contract budget: $133,232 over 3 years Sep 1, 2003 - August 31, 2006 1st year = US$10,500 2nd year = US$10,500 3rd year = US$10,500 Role on project: Co-applicant

Canadian Institutes of Health Research Group Grant AC Evans, C Bushnell, H Chertkow, A Dagher, T Paus, M Petrides, B Pike, R Zatorre “ The physiology and pathophysiology of neuronal activation” $4,650,693 over five years 2000-2005 1st year = $ 1,161,613 + 248,327 for equipment 2nd year = $ 1,189,182 3rd year = $ 683,857 4th year = $ 683,857 5th year = $ 683,857 Role on project: PI

NIH Operating Grant Neuroinformatics Tools Initiative (NIFTI) AC Evans, GB Pike, DL Collins, KJ Worsley “ Web-based aMRI/fMRI database” $US 250,000 p.a. over 4 years Oct 2002 - Sept 2006 1st year = $250,000 2nd year = $250,000 3rd year = $250,000 4th year = $250,000 Role on project: PI

NIH R21 Operating Grant AC Evans, B Bedell, R Del Maestro, S Mzengeza, B Pike, A Sadikot “Novel MRI probes for in vivo molecular imaging” $741,112 over 4 years Jul 1, 2004 - Jun 30, 2008 1st year = $125,000 2nd year = $125,000 3rd year = $245,556 4th year = $245,556 Role on project: PI

7 7 FRSQ Team Award J. Doyon, AC Evans (co-PIs), G. Beaudoin, H Chertkow, P Bourgouin, S Lupien, Y Joanette, GB Pike, M Lassonde, R Zatorre, F Lepore, M Petrides, J Hurtubise “Regroupement Provincial de Recherche en Imagerie Cérébrale (REPRIC) ” $ 200,000 p.a. over 2 years Sep 2002 - Aug 2004 1st year = $200,000 2nd year = $200,000 Role on project: co-PI

Human Brain Map Project: Phase II Renewal AC Evans, T Paus, B Pike, K Worsley $ 120,000 p.a. for five years 2003-2008 MNI component of a multi-center P20 proposal to construct a digital reference system for the human brain. Overall Consortium PI: J Mazziotta (UCLA) Overall Consortium Award: $ 1.1M p.a. for five years 2003 - 2008 1st year = $120,000 2nd year = $120,000 3rd year = $120,000 4th year = $120,000 5th year = $120,000 Role on project: Site PI

National Institute of Mental Health (NIMH) Research Contract AC Evans, N Lange, G Leonard, JC Mazziotta, J McCracken, T Paus, M Petrides, B Pike, AW Toga, K Worsley, T Zeffiro “ Data Coordinating Centre (DCC) for a MRI Study of Normal Brain Development” $US 7,385,716 over 7.25 years 2001-2008 1st year = $ 1,237,336 2nd year = $ 979,062 3rd year = $ 1,008,133 4th year = $ 1,038,077 5th year = $ 1,068,920 6th year = $ 969,227 7th year = $ 862,810 8th year = $ 221,151 Role on project: PI

Canada Foundation for Innovation Research Infrastructure Award AC Evans, GB Pike, T Paus, MJ Meaney, R Quirion, L Descarries, H Chertkow, DL Arnold, S Lupien, JC Hurtubise “ Montreal Consortium for Brain Imaging Research (MCBIR)” $28,504,134 over 4 years 2000-2003 Role on project: PI

CIHR Senior Scientist Career Award AC Evans “Automated analysis of 3D brain imaging data ” $ 70,000 + fringes p.a. over 5 years Sep 2003 - Aug 2008 1st year = $70,000 2nd year = $70,000 3rd year = $70,000 4th year = $70,000

8 8 5th year = $70,000 Role on project: PI

FRSQ Team Award M Meaney, LR Atkinson, AC Evans, AS Fleming, S Goldberg et al. “ Maternal adversity, vulnerability and neurodevelopment ” $ 750,000 p.a. over 5 years Aug 2003 - July 2008 1st year = $461,800 + 57,300 equipment 2nd year = $730,900 3rd year = $750,000 4th year = $750,000 5th year = $750,000 6th year = $250,000 Role on project: co-applicant

CANARIE Network Enabled Platform Program AC Evans $ 2,400,385 over three years June 1, 2008 – Aug 31, 2011 “Canadian Brain Research Network (CBRAIN)” 1st year = $854,870 2nd year = $884,027 3rd year = $661,489 Role in project: PI

CIHR Operating Grant $632,895 over 4 years from 10/2008-09/2012 “Multi-parametric imaging studies of novel therapeutic agents in rodent models of glioma” PI: Barry Bedell $632,895 over 4 years from 10/2008-09/2012 Role in project: co-applicant

CIHR Operating Grant $555,681 over 2 years from 10/2008-09/2010 “Integrated in vivo and ex vivo characterization of cerebrovascular dysfunction and its consequences in transgenic models of Alzheimer's disease” P.I. Barry Bedell Role in project: co-applicant

CANARIE Network Enabled Platform Program AC Evans $ 1,800,000 over two years Aug 1, 2009 – Jul 31, 2011 “Global Brain Research Network (GBRAIN)” 1st year = $900,000 2nd year = $900,000 Role in project: PI

CIHR JAPAN-CANADA Joint Health Research Program AC Evans $ 60,000 over two years Sep 1, 2008 – Aug 31, 2010 “The neuroarchitectonic determinants of EEG recordings” 1st year = $30,000 2nd year = $30,000 Role in project: Canadian PI

9 9 NIH Autism Centers of Excellence (ACE) Networks Grant AC Evans $ 1,590,200 over five years 2007-2012 Data Coordinating Center (DCC) for 4-center Autism Centers of Excellence (ACE) network “A longitudinal MRI study of infants at risk for autism” Overall Network PI: J Piven 1st year = $322,040 2nd year = $317,040 3rd year = $317,040 4th year = $317,040 5th year = $317,040 Role on project: DCC-PI

European Commission AC Evans $30,000 over 2 years May 1,2009 to April 30, 2011 “A Worldwide Infrastructure For Computational Neuroscientists (outGRID)” Role on project: Collaborator

Canadian Institutes of Health Research Operating Grant AC Evans “3D Morphometry of human cortex” $740,890 over five years April 2008 - March 2013 1st year = $148,164 2nd year = $148,178 3rd year = $148,178 4th year = $148,178 5th year = $148,178 Role on project: PI

10 10 Current Grants:

Canadian Institutes of Health Research Operating Grant AC Evans, BJ Bedell “Cortical connectivity in neurodevelopment and neurodegeneration” $755,820 over five years April 2013 - March 2018 1st year = $134,155 2nd year = $159,966 3rd year = $164,111 4th year = $146,595 5th year = $150,993 Role on project: PI

NIH Autism Centers of Excellence (ACE) Networks Grant AC Evans $ 1,100,000 over five years 2012-2016 Data Coordinating Center (DCC) for 4-center Autism Centers of Excellence (ACE) network “A longitudinal MRI study of infants at risk for autism” Overall Network PI: J Piven Role on project: DCC-PI

CIHR CEEHRC Epigenomics Platform - Epigenomic Data Coordination Centre (EDCC) Program Bourque G and AC Evans $ 1,470,535 over 5 years April 1, 2012 – March 31, 2017 “Integrative Epigenomic Data Coordination Centre (EDCC) at McGill” 1st year = $294,107 2nd year = $294,107 3rd year = $294,107 4th year = $294,107 5th year = $294,107 Role in project: Co-PI

James McGill Chair AC Evans $ 125,000 over 5 years Sep 1, 2009 – Aug 31, 2014

Autism Speaks, CROSS, IBIS-EARLI AC Evans $121,000 USD over 5 years Jan 1,2009 – Dec 31, 2013 “Collaborative Risk and Outcome Scientific Study” Role on project: Data Coordinating Centre (DCC) P.I.

National University of Singapore AC Evans $360,000 over 5 years April 1, 2009 to March 31, 2014 “Growing Up in Singapore Towards healthy Outcomes (GUSTO)” Role on project: Data Coordinating Centre (DCC) P.I.

Canada National Centers of Excellence, NeuroDevNet, NeuroInformatics AC Evans $360,000 over 3 years May 1,2010 to Apr 30,2013 Role on project: Data Coordinating Centre (DCC) P.I.

11 11 Canada National Centers of Excellence NeuroDevNet, Autism sub-project AC Evans, K Hyde $531,000 over 3 years May 1, 2010 to April 30, 2013 Role on project: co-P.I

European Commission AC Evans $90,000 over 3 years July 1, 2011 to Jun 30, 2014 “NeuGRID for you (N4U)” Role on project: Collaborator

Helmholtz Society AC Evans $100,000 over 2 years Jan 1, 2012 to Dec 31, 2013 Role on project: Co-P.I. “Generation of a Computational Microstructural Model of the Human Brain”

Julich Research Center AC Evans $100,000 over 2 year Jan 1, 2012 to Dec 31, 2013 Role on project: P.I. “LORIS database for the 1000 brains project of the INM-1”

European Union – FET Program AC Evans “Human Brain Project” $3,100,000 over 10 years Jan 1, 2014 to Dec 31, 2023 Role on project: Collaborator

Canadian Institutes of Health Research International Collaborative Research Strategy for Alzheimer’s Disease (ICRSAD) Program AC Evans “CBRAIN: A national platform for neurodegenerative disease imaging” $225,000 over 3 years September 1, 2013 – August 31, 2016 Role on project: P.I.

Canadian Institutes of Health Research Catalyst Grant: Exploring ADNI and other Neuroimaging Databases to benefit the early detection of Alzheimer's Disease and Related Dementias AC Evans “Anatomical and functional correlates of metabolic change and cognitive decline in Alzheimer's disease: Multivariate approaches for early identification of at-risk population" $100,000 over 2 years April 1, 2014 – March 31, 2016 Role on project: P.I.

Brain Canada – Azrieli Foundation Nerodevelopmental Research Program AC Evans “Structural and functional networks in Autism Spectrum Disorder and Fragile X Syndrome” $2,492,735 over 3 years April 1, 2014 – March 31st, 2019 1st year = $479,000 2nd year = $488,580 3rd year = $498,352 4th year = $508,319 5th year = $518,485 Role on project: P.I.

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CANARIE Research Platform Interface (RPI) Program AC Evans $117,160 over 1.5 years January 1, 2014 – Jun 30th, 2015 “Generic 3D Web-Viewer Service (3DWebViz)” Role in project: P.I.

AWARDS

Computerworld-Smithsonian Award for Innovation in Medicine (1999)

MICCAI-NDI Tokyo Award for Scientific Presentation (2002) Cocosco CA, Zijdenbos AP, Evans AC “Automatic generation of training data for brain tissue classification from MRI”

CIHR Senior Scientist Award (2003)

James McGill Professor Award (2009)

13 13 CONSULTANT DUTIES 1. National Academy of Science/Institute of Medicine (NAS/IOM) Task Force on Human Imaging aspects of a National Neural Circuitry Database (NNCD), Irvine, February, 1990 2. National Academy of Science/Institute of Medicine (NAS/IOM) Research Briefing Panel on "Imaging Biological Events", Washington, February, 1991 3. Canadian government delegate, Neuroinformatics Subcommittee, Bioinformatics Work Group: Organization for Economic Cooperative Development (OECD) Megascience Forum (1996-date). 4. National Institute of Aging Workshop on Human Brain Project, Washington, February 1992 5. External Advisory Board, Australian Human Brain Function Project (E. Gordon), Sydney, Australia. 6. External Advisory Board, Massachussets General Hosp., NeuroImaging Center(V. Caviness), Boston 7. External Advisory Board , Yale U. PET Center, New Haven, Connecticut 8. External Advisory Board, U. of Texas Health Sciences Center, Research Imaging Center: BrainMap Project (P. Fox), San Antonio 9. External Advisory Board , Austin-Heidelberg Medical Center PET Program (S. Berkovic), Melbourne, Australia 10.External Advisory Board , Cornell University/Memorial Sloan Kettering Cancer Center, Department of Psychiatry PET Center (R. Blasberg), New York 11.External Advisory Board , National Institute of Aging Laboratory of Personality and Cognition (S. Resnick), Baltimore 12.External Advisory Board , Hungarian PET Center (B. Gulyas), Debrecen, Hungary (1995-date) 13.Scientific Advisory Board , Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford. (1996 - date) 14.External Consultant, Johns Hopkins PET Center (D. Wong), Baltimore 15.External Consultant, Mental Health Clinical Research Center, University of Iowa (N. Andreasen), Iowa City. 16.External Advisor, U. of Minnesota Human Brain Project (D. Rottenberg et al.), Minneapolis, June, 2002 17.External Advisory Board, Medical Imaging Display and Analysis Group (MIDAG, S. Pizer et al.), University of North Carolina, Chapel Hill (August 2000, August 2002) 18.External Advisory Board, MIND Institute, (N. Andreasen et al.), Santa Fe, 2002-date 19.Member, C3.ca Author’s Panel for Long Range Plan (LRP) for High Performance Computing in Canada, December 2002 - October 2004 20.Member, National Consultation for Access to Scientific Research Data (NCASRD), Ottawa, November 2004 21.External Advisory Board, UC San Diego, Neuroanatomy of Primate Amygdaloid Complex (Amaral et al., 2004-date) 22. Compute Canada, Board of Directors, 2011-2012 23. CANARIE, Scientific Advisory Board 2013-date

14 14 INTERNATIONAL CONFERENCE COMMITTEE MEMBERSHIP Organizing Committee: 13th International Symposium on Cerebral Blood Flow and Metabolism, Montreal, June 1987 Scientific Program Committee: 37th Annual Symposium of the Society of Nuclear Medicine, June 1989 Organizing Committee: Annual Symposium of the Canadian College of Physicists in Medicine, Montreal, June 1990 Scientific Program Committee: 38th Annual Symposium of the Society of Nuclear Medicine, June 1990 Scientific Program Committee: 39th Annual Symposium of the Society of Nuclear Medicine, June 1991 Organizing Committee: 12nd International Conference on Information Processing in Medical Imaging (IPMI), Wye College, Kent, U.K., July, 1991. Organizing Committee: Computational Brain Atlas Workshop, Los Alamos National Laboratories/Santa Fe Neurosciences Institute, Santa Fe, New Mexico, March 1991. Organizing Committee: 2nd International Conference on Visualization in Biomedical Computing (VBC 92), Chapel Hill, North Carolina, May 1992. Organizing Committee: Human Frontier Science Program Organization (HFSPO) Workshop on The Human Brain Atlas Problem, Stockholm, Sweden, September 1992 Intenational Advisory Board: "Advanced Medical Image Processing", Official satellite meeting of IEEE- Engineering in Medicine and Biology Society Annual Symposium, Paris, France, November 1992 Scientific Program Committee: "Quantification in Brain PET", Official satellite meeting at 16th International Symposium on Cerebral Blood Flow and Metabolism, Akita, Japan, June 1993 Organizing Committee: "Advances in the Study of Functional Neuroanatomy" Official workshop at 16th International Symposium on Cerebral Blood Flow and Metabolism, Sendai, Japan, June 1993 Scientific Program Committee: 41st Annual Symposium of the Society of Nuclear Medicine, June 1993 Chairman, Organizing Committee (with Drs. Benkelfat, Gjedde), Workshop on Physiology of Cerebral Activation. Annual Conference of Society for Biological Psychiatry, Chicago, May, 1994 Organizing Committee: 3nd International Conference on Visualization in Biomedical Computing (VBC 94), Rochester, Minnesota, October 1994. Scientific Program Committee: 1st International Symposium on Functional Mapping of the Human Brain, Paris, France, June 1995 Scientific Program Committee: "Quantification in Brain PET", Official satellite meeting at 17th International Symposium on Cerebral Blood Flow and Metabolism, Oxford, U.K. June 1995. Scientific Program Committee: 2nd International Symposium on Functional Mapping of the Human Brain, Boston, U.S.A. June 1996. Chairman, Local Organizing Committee: International Workshop on "Evaluation of Multiple Sclerosis Lesion Load: Comparison of Multiple Image Processing Techniques", Montreal, November 1995. Chairman, Procedures Committee: 2nd International Human Brain Mapping Conference, Boston, U.S.A., June 1996. Scientific Advisory Committee: 4th International Conference on Visualization in Biomedical Computing (VBC 96), Hamburg, Germany, October 1996. Scientific Program Committee: 3rd International Symposium on Functional Mapping of the Human Brain (HBM97), Copenhagen, May 1997. Scientific Advisory Board, 1st International Symposium on Functional Neuroreceptor Mapping of Living Brain, Aarhus, Denmark. Official satellite meeting of (HBM97),Copenhagen, May 1997. Scientific Program Committee: "BRAINPET 97", Official satellite meeting at 18th International Symposium on Cerebral Blood Flow and Metabolism, Bethesda, U.S.A. June 1997. Chairman, Local Organizing Committee: 4th International Symposium on Functional Mapping of the Human Brain (HBM98), Montreal, Canada, June 1998 Scientific Program Committee: "Neuroreceptor Mapping 00", New York, June 2000 Scientific Program Committee: 7th International Syposium on Medical Image Computing and Computer- Assisted Intervention (MICCAI 2004), St. Malo, France, September 2004. Scientific Program Committee: 5th International Symposium on Functional Mapping of the Human Brain (HBM99), Dusseldorf, June 1999. Scientific Program Committee: 6th International Symposium on Functional Mapping of the Human Brain (HBM00), San Antonio, June 2000. Scientific Program Committee: 7th International Symposium on Functional Mapping of the Human Brain

15 15 (HBM01), Brighton, June 2001. Scientific Program Committee: 8th International Symposium on Functional Mapping of the Human Brain (HBM02), Sendai, June 2002. Chairman, Local Organizing Committee: Tourette’s Society of America Workshop on Imaging Consortium, Montreal, Canada, August 2002 Scientific Program Committee: 9th International Symposium on Functional Mapping of the Human Brain (HBM03), New York, June 2003. Scientific Program Committee: 10th International Symposium on Functional Mapping of the Human Brain (HBM04), Budapest, June 2004. Scientific Program Committee: 11th International Symposium on Functional Mapping of the Human Brain (HBM05), Toronto, June 2005. Scientific Program Committee: 12th International Symposium on Functional Mapping of the Human Brain (HBM06), Florence, June 2006. Scientific Program Committee: 12th International Symposium on Functional Mapping of the Human Brain (HBM07), Chicago, June 2007. Scientific Program Committee: 13th International Symposium on Functional Mapping of the Human Brain (HBM08), Melbourne, June 2008. Scientific Program Committee: 14th International Symposium on Functional Mapping of the Human Brain (HBM09), San Francisco, June 2009. Scientific Program Committee, International Meeting for Autism Research (IMFAR 2006), Montreal , June 2006 Scientific Program Committee, 22nd High Performance Computing Symposium, Québec City, June 9-11, 2008

OTHER ACTIVITIES Board of Directors, Brain Imaging Council, Society of Nuclear Medicine (1985-1988) Invited Discussant, Workshop on quantification in PET : 13th International Symposium on Cerebral Blood Flow and Metabolism ; Montreal, June 1987 Invited Discussant, Workshop on Dopamine, Schizophrenia and PET : Montreal, November 1987 Invited Discussant, Workshop on quantification in PET : Memorial Sloane-Kettering Cancer Center, New York, May 1989 Invited Discussant, Workshop on structure-function relationships and the metabolic anatomy of disease: 14th International Symposium on Cerebral Blood Flow and Metabolism ; Bologna, May 1989 Member, Special Review Committee for NIH Centre Proposal, “ Brain and its Vasculature ", Raichle et al. Washington University, St. Louis, May 1989 Member, Site Review Committee for NIH Centre Proposal, “ Regulation of Cerebral Glucose Utilization in normal and diabetic men with PET ", Cooper et al. University of Chicago, Chicago, December 1989 Member, Reverse Site Visit Committee for NIA Program Project Proposal, “ Neuroimaging of cognitive function in dementia", Albert et al. (Massachussetts General Hospital), National Institute of Aging, February 1992 Session Chairman, 37th Annual Society of Nuclear Medicine Symposium, Washington, June 1990 Session Chairman: Annual Symposium, Canadian College of Physicists in Medicine, Montreal, June 1990 Invited participant, Human Frontier Science Program (HFSPO) sponsored workshop on "PET Studies of Cognitive Functions", Milan, November 1990 Invited participant, Ciba Foundation Workshop on Exploring Functional Neuroanatomy using PET ; London, February 1991 Invited panelist, Panel Discussion on " Volume Visualization Comes of Age: The State of the Art in Technology and Application " at IEEE Visualization ’91 Conference ; San Diego, October 1991 Session Chairman: Workshop on "Cognition in the Brain: Investigations Using PET", Massachussetts General Hospital; Boston, Massachusetts, June 1991. Track Chairman: Annual Symposium of the IEEE Engineering in Medicine and Biology Society, Orlando, Florida, October 1991 Invited discussant, UCLA Workshop on Primate Brain Mapping, Washington, November 1991 Session Chairman: “Visualization in Biomedical Computing ’92" Conference, Chapel Hill, October 1992 Session Co-Chairman: NIMH workshop on “Advances in Functional NeuroImaging: Technical

16 16 Foundations", Bethesda, October 1992 Session Chairman: BrainMap Advisory Board Meeting, San Antonio, November 1992 Invited discussant, McDonnell-Pew Workshop on quantitative volumetric analysis of human brain structure, Salk Institute, San Diego, April, 1994 Invited discussant, NICHD Workshop on Tools for Pediatric NeuroImaging, Washington, September 1997 Member, Neuroimaging Section, World Psychiatric Association, 1994-present Member, International Review Panel for German Helmholtz Society. Site Visit of Program for Helmohltz Society Program Grant of Dr. Karl Zilles et al., "Function and Dysfunction of the Nervous System", Jülich, Germany, July 2002 Chairman, NIH Review Panel for Data Coordinating Centers for Autism Network (2003) Member, Advisory Board for NIH Collaborative Program of Excellence in Autism (CPEA) (2004-date) Invited discussant, Trans-NIH Workshop on Incidental Findings, January 2005 Invited discussant, Macy Foundation Conference “The Convergence of Neuroscience, Behavioral Science, Neurology and Psychiatry”, January 2005 Scientific Advisory Board, Multi-modal neuroimaging, Pfizer, New York , January, 2006 Invited Discussant, NIH Blueprint Workshop on linking large-scale multi-center NIH projects (2006) Member, Community Planning and Advocacy Council, Compute Canada (2010) Member, Board of Directors, Compute Canada (2010) Invited participant, CFI Workshop on Cyber-infrastructure, January, 2014 Invited participant, Digital Infrastructure Summit, January, 2014

17 17 PROFESSIONAL ORGANIZATIONS Organization for Human Brain Mapping Compute Canada CANARIE

JOURNAL REVIEWER Editorial Board: Human Brain Mapping Editorial Board: Neuroimage Journal Cerebral Blood Flow and Metabolism Journal of Nuclear Medicine Medical Physics Neuroimage Biological Psychiatry Journal of Neuroimaging Methods IEEE Transactions on Medical Imaging American Journal of Neuroradiology Proceedings of the National Academy of Sciences J Cognitive Neuroscience Cerebral Cortex

GRANTING AGENCY REVIEWER

Member - NIH Diagnostic Radiology Study Section (1994-1998) Canadian Medical Research Council (MRC) Natural Science and Engineering Research Council (NSERC) U.S. National Institutes of Health (NIH) U.S. National Science Foundation (NSF) Sterling-Winthrop Imaging Research Institute British Columbia Health Care Research Foundation B.C. Center for Integrated Computer Systems Research The Charles Dana Foundation National Cancer Institute of Canada (NCIC) - Site visit Chairman (2000) American Multiple Sclerosis Society Helmholtz Society - Germany (2002, 2003) Candian Institutes of Health Research (CIHR) – Neurosciences A Committee (2002) Candian Institutes of Health Research (CIHR) – Behavioural Sciences Committee (2003) Candian Institutes of Health Research (CIHR) – Group Grants Committee (2003,2004) Candian Institutes of Health Research (CIHR) – New Investigators C Committee (2005, 2006) NIH Special Emphasis Review Panel (Chair) – BDCN-G (2005) National Center for Research Resources (NCRR) Review Panel (2005) Chairman, CFI Review Panel (2006)

COMMITTEE MEMBERSHIP - McGill/MNI PET Unit Planning and Priorities Committee (1984-1985) Brain Imaging Center Executive Committee (1985-86) PET Unit Space Committee (1988-89) MNI Institutional Space Committee (1988-90) PET Scheduling Committee (1986-1990) PET Software Committee (1986-date) PET Working Committee (1990-date) MRI Research Committee (1992-date) MNI Research Advisory Committee (RAC) (1992-date) MNI Task Force on the Molecular Basis of Cognition (1993) MNI Visioning Task Force (1993) Graduate Committee, Dept. of Biomedical Engineering(1994-date)

18 18 MNI Search Committee - Chief of Nuclear Medicine (1994) MNI Search Committee - Epilepsy Neurologist (1994) MNI Search Committee - Movement Disorders Neurologist (1994) Chairman, MNI Search Committee - PET receptor physiologist (1994) Faculty Promotions Committee (1995-date) McGill Psychiatry Boeck Chair (2004-5) McGill Psychiatry Faculty Search Committee (2004-2005) MCBIR Search Committee (2004-date) McGill Promotions Committee (2005-date) McGill Computer Committee (2006-date) McGill Supercomputer Steering Committee (2007-date)

19 19 TEACHING AND SUPERVISORY RESPONSIBILITIES POSTGRADUATE CLASSES

Nuclear Medicine Seminars , Medical Physics M.Sc. Program (1987-1995) Course 563-615A Physics of Nuclear Medicine (with Dr. GW Dean, 1994-1996) Physical Principles: Theory of gamma-ray production ; Scintillation crystals ; Anger principle , Scanner geometries; Gamma-camera, SPECT, PET scanner design ; Imaging physics ( calibration, resolution, attenuation, scatter, randoms, dead-time, noise), Image Reconstruction. Biological Modelling: Theory of compartmental models ; Dynamic PET ; Schedule optimization ; Receptor binding, Oxygen models, Glucose models, pH models ; Biological applications in Stroke, Epilepsy, Tumour, Movement Disorders.

Protein Crystallography Seminars, Medical Physics M.Sc. Program (1988-1993) Fundamentals of protein stereochemistry and function: Amino acids, Hydrophilicity, Peptide bond, Sulphide bond, Hydrogen bond Ramachandran diagrams, alpha-helix, beta-sheet, tertiary/quaternary structure, cofactors. Crystallography: Crystal lattices, space/point groups, Bragg reflection, Fourier theory of diffraction pattern , Phase problem, Isomorphous replacement, Direct methods, Anomalous scattering, R-factors, Electron density maps, Difference Fouriers, Real/reciprocal space refinements, Optical model-building, Computer imaging/analysis of structure maps.

Basic Science Tutor, Neurology/NeuroSurgery Residency Program (1989) Positron Emission Tomography. NeuroImaging.

Neuroimaging Seminars , CNS Course in McGill Medical Program (1994-1997) Coordinator: MNI Brain Mapping Workshops (1993-97) Leading discussion groups for research students and faculty, primarily from Neuroimaging and Neuropsychology, on current issues in functional and structural mapping of normal brain.

BME 399-501 Selected topics: Population-based MRI Studies (2002-date)

Autism Research Training (ART) Summer Program: Neuroimaging (2004, 2005)

20 20 MCGILL UNIVERSITY RESEARCH COLLOQUIA 1. Department of Neurology and Neurosurgery: PET Seminars, 1984 Direct- and cross-slice quantification: A comparison of experimental and patient results

2. Department of Communication Disorders: Colloquium, 1985 The complementary roles of Positron Emission Tomography and Magnetic Resonance Imaging in the study of language

3. Department of Neurology and Neurosurgery: PET Seminars, 1985 Study of metabolic and haemodynamic coupling in Huntington’s Disease by positron emission tomography

4. Department of Neurology and Neurosurgery: PET Seminars, 1986 Noise transport in the FDG kinetic model (with S. Jovkar)

5. Medical Physics Unit: Colloquium, 1986 The effect of variable axial resolution on quantification with the Therascan 3128 PET scanner: Comparison of phantom and patient data

6. Medical Physics Unit: Colloquium, 1986 Simultaneous determination of cerebral blood volume and rate constants for the FDG model using a computer-controlled infusion schedule

7. Medical Physics Unit: Colloquium, 1987 A linear, noise-resistant formulation for the 3-compartment, 4-rate constant model of tracer uptake

8. Medical Physics Unit: Colloquium, 1987 Anatomical-functional correlation using an adjustable MRI- based region of interest atlas with positron emission tomography

9. Department of Neurology and Neurosurgery: PET Seminars, 1987 A computerized atlas of the human brain

10. Department of Neurology and Neurosurgery: PET Seminars, 1988 Domoic acid intoxication from tainted mussels (with A. Gjedde)

11. Department of Neurology and Neurosurgery: PET Seminars, 1988 Three-dimensional correlation of MRI and PET

12. Department of Neurology and Neurosurgery: Grand Rounds, 1988 PET investigation of neurological deficit following domoic acid intoxication (with A. Gjedde, J. Teitelbaum, S. Carpenter)

13. Department of Neurology and Neurosurgery: PET Seminars, 1989 Performance characteristics of the PC-2048B PET tomograph

14. Department of Neurology and Neurosurgery: PET Seminars, 1989 The PEARL technique for PET image averaging: Progress and Limitations

15. Medical Physics Unit: Colloquium, 1989 Three-dimensional display and analysis of MRI and PET images using a volume-of-interest (VOI) atlas

16. Biomedical Engineering Unit: Colloquium, 1989 Correlative display and analysis of MRI and PET images

17. Department of Neurology and Neurosurgery: Grand Rounds, 1989 PET studies of normal cortical CBF response to activation tasks (with E. Meyer, R. Zatorre)

18. Department of Mathematics: Colloquium 1989 In-vivo imaging of human brain anatomy and physiology

21 21 19. Department of Neurology and Neurosurgery: Neuroscience Seminars, 1989 Three-dimensional imaging of brain function and anatomy

20. Medical Physics Unit: Colloquium, 1990 Brain morphometrics using a three-dimensional computerized neuroanatomical atlas

21. Department of Neurology and Neurosurgery: PET Seminars, 1990 Progress in 3-D anatomical- functional correlation analysis

22. Medical Physics Unit: Colloquium, 1990 Kinetics of tracer uptake in the brain

23. Department of Neurology and Neurosurgery: Grand Rounds, 1990 PET studies of visual word and picture processing (with D. Bub, H. Chertkow, E. Meyer)

24. Brain Imaging Centre Seminars, M.N.I., 1991 Peak analysis in cognitive activation studied with PET

25. Seminars in Neuropsychology, M.N.I., 1991 Cognitive activation studies using PET

26. Department of Neurology and Neurosurgery: Brain Imaging Seminars, 1991 Confocal Microscopy. What it can do for neuroscience

27. Brain Imaging Centre Seminars, M.N.I. , 1991 A new approach to statistical analysis of PET activation studies (with K. Worsley)

28. McDonnell-Pew Cognitive Neuroscience Seminar Series, 1991 Applications of anatomical segmentation of MRI image data

29. McDonnell-Pew Cognitive Neuroscience Seminar Series, 1992 Anatomical localization of function (with D. Bub, A. Gjedde)

30. Department of Biomedical Engineering: Colloquium, 1992 Anatomical/functional brain mapping using MRI and PET

31. Department of Neurology and Neurosurgery: Grand Rounds, 1992 Quantitative imaging of mesial temporal structures in temporal lobe epilepsy (with F. Cendes, T. Peters and M. Jones-Gotman)

32. Department of Neurology and Neurosurgery: Neuroscience Seminars, 1992 Brain Mapping with MRI and PET

33. Department of Neurology and Neurosurgery: Neuroscience Seminars, 1994 Neuroimaging of cognitive function

34. Department of Psychology, 1998 Mapping the structure and function of the human brain

35. Department of Physics, January 2001 Brain imaging Research at McGill

36. Montreal Neurological Institute, Donor Day, May 2002 Viewing the brain from the inside out: Penfield’s vision revisited in the 21st century

37. Department of Neurology, Grand Rounds, December 2002 Quantitative neuroanatomy of normal and disordered brain using voxel-based morphometry and cortical thickness analysis

38. Brain Imaging Centre Lecture Series, February 2004 The NIH MRI Study of Normal Brain Development

22 22 39. Brain Imaging Lecture Series, October, 2005 Brain morphometry studied with MRI

40. McGill Supercomputing Planning Workshop, July 2007, Global brain imaging research network

41. MNI Open Day, March 2008 Imaging the living brain

42. MUHC Psychiatry Rounds, September 2009 Brain mapping of cortical anatomy: Methods and applications

43. McGill Faculty of Medicine Town Hall Meeting, Janauary 2010, McGill Centre for Neuroinformatics and Genomics (MCNG)

44. MNI Brain Imaging Centre Seminars, March 2010, Cortical morphometry in neurodevelopment and neurodegeneration

45. Douglas Hospital, February 2011, CBRAIN: A grid architecture for brain imaging analysis in neurodegenerative disease

EXTERNAL INVITED SEMINARS

1. Ontario Health Association ,Ottawa, 1983, Positron Emission Tomography

2. Science Focus Ottawa, 1983, Initial results from the Therascan 3128 PET Tomograph

3. Ottawa Speech and Hearing Association, Ottawa, 1983 The applications of Positron Emission Tomography in the study of language pathology

4. Memorial Sloane-Kettering Cancer Center, 1986 New York, 1986 The effect of vascular activity in the determination of rate constants for the uptake of F-18 labelled 2-fluoro-2-deoxy-D-glucose: Error analysis and normal values in older subjects

5. National Institute of Health,Washington,1987 Anatomical-functional correlation using an adjustable MRI-based region-of-interest atlas with positron emission tomography

6. University of Toronto Toronto, May 1988 Physics and Clinical Applications of Positron Emission Tomography

7. Working Group on Quantification in Positron Emission Tomography, Memorial Sloan Kettering Cancer Center, New York, May 1989 MRI-PET correlation in three dimensions using a volume-of- interest (VOI) atlas

8. World Conference on Clinical Pharmacology and Therapeutics Mannheim-Heidelberg, July 1989 Regional 3-dimensional correlation of positron tomographic and magnetic resonance studies of brain metabolism and pharmacology

9. American Association of Physicists in Medicine Memphis, July 1989 Three-dimensional correlation of PET and MRI in the human brain

10. National Institute of Mental Health Washington, December 1989 Three-dimensional anatomical- functional correlation using an adjustable MRI-based volume-of-interest atlas with PET

11. University of Pennsylvania, Philadelphia, September 1989 Three-dimensional imaging of brain anatomy and function

23 23 12. University of Michigan Ann Arbor, October 1989 A computerized volume-of-interest (VOI) atlas of the human brain for anatomical-functional correlation

13. University of Toronto Toronto, November 1989 Three-dimensional correlation of PET and MRI in the human brain

14. NORDPET: First Scandinavian Symposium on PET Copenhagen, December 1989 Three- dimensional imaging of brain anatomy and function

15. National Academy of Science/Institute of Medicine (NAS/IOM) Task Force on Clinical Aspects of a National Neural Circuitry Database Irvine, February 1990 A deformable computerized atlas of the human brain

16. University of British Columbia,Vancouver, April 1990 Anatomical/Functional image correlation in three dimensions

17. Harvard University, Massachusetts General Hospital, Boston, May 1990 Three-dimensional display and analysis of cerebral anatomy, function and vasculature

18. Annual Symposium of the Canadian College of Physicists in Medicine Montreal, June 1990, Three- dimensional NeuroImaging: Clinical and Research Applications

19. 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Philadelphia, November 1990 3-D neuroimage segmentation with a volume-of-interest atlas

20. Human Frontier Science Program workshop on PET studies of cognitive function, Institute H.S. Raffaele, Milan, November 1990 Neuroanatomical segmentation by non-linear warping of a 3-D volume-of-interest atlas

21. McDonnell-Pew Cognitive Neuroscience Center Program, Annual Workshop San Diego, January 1991 Stereotactic mapping of cognitive events with correlated MRI and PET subtraction images

22. National Academy of Science/Institute of Medicine (NAS/IOM) Research Briefings Panel on "Imaging Biological Events",Washington, February 1991 Multi-modality Brain Image Integration and Segmentation

23. Ciba Foundation workshop on exploring functional neuroanatomy using positron emission tomography, London, March 1991 Correlative imaging of averaged MRI and PET subtraction data in stereotactic coordinates space

24. Computational Brain Atlas Workshop, Santa Fe, New Mexico, March 1991Functional/anatomical image analysis using a computerized 3-D neuroanatomical atlas

25. John Abbott College, Public Lecture, Santa Fe, New Mexico, March 1991 Toward a computational brain atlas

26. IBM Conference on "The use of computers in clinical medicine" McGill University, Montreal, May 1991 3-D correlative imaging of structure and function

27. General Electric Medical Systems Research Laboratories Schenectady, New York, May 1991, Multi-modality integration and segmentation

28. Workshop on " Cognition in the Brain: Investigations Using PET " Massachussetts General Hospital, Boston, Massachusetts,June 1991 Antomical mapping of cognitive activation foci studied by PET

24 24

29. Vanderbilt University, Nashville, September 1991 Three-dimensional imaging of cerebral anatomy, physiology and vasculature

30. 13th Annual International Conference of the IEEE Engineering in Medicine and Biology Society Orlando, November 1991 Three-dimensional warping of a computerized brain atlas

31. 13th Annual International Conference of the IEEE Engineering n Medicine and Biology Society Orlando, November 1991 Multi-modal imaging

32. Annual Meeting, Western Regional Society of Nuclear Medicine Copper Mountain, Colorado, January 1992 Three-dimensional correlative imaging of brain anatomy, function and vasculature

33. National Institute of Aging: Human Brain Project Workshop, Washington, February 1992, Anatomical/Functional Brain Mapping

34. University of Pittsburgh Medical Center, Pittsburgh, February 1992 Multimodality NeuroImaging

35. Network of Centres of Excellence (NCE) on Neural Regeneration, Toronto, March 1992 Quantitative Multimodality NeuroImaging

36. N.I.M.H. Workshop on Advances in Functional NeuroImaging, Washington, September 1-4, 1992 Feature-based 3-D MRI/PET registration and segmentation

37. Advanced NATO research workshop on magnetic resonance and epilepsy,The National Hospital, Queen Square, London, U.K., October 1-4, 1992 3-D Image Reconstruction and MRI

38. N.I.H. Diagnostic Radiology Study Section Workshop on Multi-modality Imaging, Washington D.C., October 13, 1992 Multi-modality brain imaging

39. N.I.M.H. Workshop on Human Brain Mapping Project, Society of Neuroscience Annual Convention, Los Angeles, October 25, 1992 A 250-member MRI atlas of normal human brain

40. University of London, UMDS, London, U.K., October 1992 Multimodality NeuroImaging

41. University of Rennes, Rennes, France, November 1992 Multimodality NeuroImaging

42. Centre Hospitalier Universitaire, Caen, France, November 1992 Multimodality NeuroImaging

43. National Institute of Aging, Baltimore, February 1993 Functional and anatomical brain mapping

44. Washington University St. Louis, April 1993 Brain mapping with PET and MRI

45. Lead lecture,“Standardization and Registration in PET" session, Brain PET ’93 Symposium: Akita, Japan, May 1993 3-D Multi-modality human brain mapping: Past, Present and Future

46. Human Functional NeuroImaging Summer School, Cold Springs Harbor, June 1993, Recent advances in multi-modality brain mapping

47. American Psychological Society Annual Symposium: Human Brain Map Workshop, Chicago, June 26 1993 Intersubject comparisons in neuroimaging

48. N.I.C.H.D. Workshop on Frontiers in NeuroImaging, Washington, July 14-16, 1993 Critical issues in the quantification of developing brain structures

25 25 49. Annual Symposium of the Optical Sciences Association, Toronto, October 1993 Brain Mapping with MRI and PET

50. Annual Symposium of the Society for Magnetic Resonance Imaging (SMRI), Dallas, March 1994 The relative merits of MRI and PET in cognitive neuroimaging

51. Workshop on Advanced Neuroimaging in Epilepsy, Mayo Clinic, Rochester, March 1994, Cortical surface analysis from 3-D MRI images (with D. MacDonald, T. Peters)

52. Symposium on Emission Tomography: Controversies and Future Directions, Cairns Australia, October 1994, Co-registration of functional and structural images: What’s the problem ?

53. Symposium on Emission Tomography: Controversies and Future Directions, Cairns Australia, October 1994, Statistics and damned lies: Assessing cerebral activation

54. University of Melbourne, Austin-Heidelberg Hospital, Melbourne, Australia, October 1994 Recent progress in multi-modal neuroimaging

55. University of New South Wales, Sydney, Australia, October 1994, Functional neuroanatomy of human cognition using MRI and PET

56. Centre for Biomedical Technology Annual Lecture, University of Technology, Sydney, Australia, October 1994 New perspectives in multi-modal neuroimaging

57. Advanced NATO research workshop on magnetic resonance and epilepsy, Mayo Clinic, Rochester, October 1994 Cortical surface analysis from 3-D MRI images

58. Workshop in Information Science and Medical Images, Singapore, December 1994 New perspectives in multi-modal neuroimaging

59. Workshop on functional MRI at 2nd International Conference on Functional Brain Mapping, Boston, U.S.A., June 1996 Brain Atlases and Cortical Flattening

60. Medicine 2001: International Symposium on Biomedical Computing Montreal, Canada 3D imaging in the medical curriculum

61. Medicine 2001: International Symposium on Biomedical Computing, Montreal, Canada Plenary session: "The digital man or the electronic modelization of the human body"

62. 4th International Congress on Visualization in Biomedical Computing Hamburg, Germany, October 1996, Keynote Lecture: Progress towards a probabilistic atlas of human neuroanatomy

63. 1st International Symposium on Functional Neuroreceptor Mapping of Living Brain, Aarhus, Denmark, May 1997 Keynote Lecture: Brain Mapping: From blood flow to receptors via neuroanatomy

64. NOVARTIS Pharma Inc., Basel, Switzerland, September, 1997 Brain Imaging at the Montreal Neurological Institute

65. Rudolf Magnus Institute for Neurosciences, Annual Symposium, University of Utrecht, Utrecht, Holland, September, 1997 Keynote Lecture: Mapping the structure and function of the human brain

66. National Institute for Child Health and Development (NICHD) Workshop on Tools for Pediatric Neuroimaging,,Washington, September, 1997 Fully automated 3D regional parcellation of large MRI databases: Applications in normal brain and neuropathology

26 26

67. Centre for Functional Neuroimaging, London U.K., January, 1998 Structure-Function Human Brain Mapping

68. Annual Symposium: Canadian Organization of Medical Physicists (COMP), London, Ontario, June 1998 Keynote Lecture: Functional neuroimaging

69. Japan-Canada Neuroscience Partnership (JCNP) Workshop, Lake Kawaguchi, Japan, August 1998 Neuroimaging of Cognition

70. Osaka Biosciences Institute, Osaka, Japan, August 1998 Mapping the Structure and Function of the Human Brain

71. Akita Institute for Brain and Blood Vessels, Akita, Japan, August 1998 Mapping the Structure and Function of the Human Brain

72. National Institute of Mental Health Workshop on Pediatric Development, Washington, February 2000 The MRI Pediatric Database Project: Overview

73. National Institute of Mental Health Workshop on Pediatric Development, Montreal, September 2000 Progress on the MRI Pediatric Database Project

74. National Institute for Aging Workshop on Aging, Genes and Environmental Susceptibility (AGES) Project, Washington, March, 2001 Fully automated 3D analysis of large MRI databases: Applications in normal brain and neuropathology

75. Santa Lucia Institute, Rome, June 2001 Anatomical brain mapping at the Montreal Neurological Institute

76. Tourette’s Society of America, New York, February, 2002 Automated 3D analysis of large image databases

77. National Institute of Mental Health, Washington, April 2002 Pediatric MRI Database Project

78. Pediatric MRI Project Workshop, Irvine, California, May 2002 Overview of project status

79. Bio-santé Quebec, Montreal, Quebec, May 2002 Automated 3D image analysis in clinical trials

80. 8th International Conference on Human Brain Mapping, Sendai, Japan, June 2002 Morphometric Mapping of Cerebral Cortex

81. 1st Korean Human Brain Mapping Symposium, Seoul, S. Korea, June 2002 Automated 3D mapping of neuroanatomy in normal and diseased brain

82. Counterdrug Technology Assessment Center - National Institute of Drug Abuse Workshop on Characterization of Drug Addiction, Boston, July 2002 Bioinformatics of large-scale MR image database analysis

83. Tourette’s Society of America, Imaging Consortium Workshop, Montreal, August 2002 Pediatric MRI atlas of brain development

84. International Conference on the Structural Basis for Understanding Human Brain Function and Dysfunction, Santa Lucia Institute, Rome, October 2002, Structural brain mapping

85. RISQ 2002 Conference, Montreal, November 2002 Brain Mapping: A Global Community

27 27

86. Annual CANARIE Conference, Montreal, November 2002 Brain imaging networks

87. University of Montreal, Cognitive Neuroscience Seminars, Montreal, January 2003 Quantitative neuroanatomy in normal and disordered brain

88. National Institute of Mental Health, Washington, February 2003, Cortical thickness measurement in normal and disordered brain

89. Masschusetts General Hospital, Harvard Medical School, Boston, March 2003 Quantitative neuroanatomy in normal and disordered brain

90. Vogt-Brodmann Symposium, University of Dusseldorf, April 2004, Large-scale morphometric analysis of neuroanatomy and neuropathology

91. New York Psychiatric Institute/Columbia University, New York, May 2004 The promise of neuroimaging

92. Pediatric Functional Neuroimaging: A Trans-NIH Workshop, National Institutes of Health, Washington, May 2004 The NIH Study of Normal Brain Development

93. International Conference on Functional Human Brain Mapping (HBM04), Budapest, June 2004 Large-scale morphometric analysis of neuroanatomy and neuropathology

94. 2nd International Conference on Medical Imaging and Augmented Reality (MIAR04), Beijing, August 2004 Morphological MRI analysis of pediatric brain development

95. National Institutes of Health, Washington, January 2005 MRI Study of Normal Brain Development: MRI and Database

96. University of Montreal, Montreal, January 2005 Morphometric analyisis of normal and disordered brain

97. Invited discussant, Trans-NIH Workshop on Incidental Findings,Washington DC, January 2005

98. Invited discussant, Macy Foundation Conference, Phoenix AR, January 2005, The Convergence of Neuroscience, Behavioral Science, Neurology and Psychiatry,

99. International Conference on Prevention of Dementia, Philadelphia, June 2005 Focal cortical thickness change in Alzheimer’s Disease

100. International Conference on Functional Human Brain Mapping (HBM05), Toronto, June 2005 Cortical thickness mapping

101. National Institutes of Health, Washington, November 2005 MRI Study of Normal Brain Development: MRI and Database

102. Brainstorm ’06 , Aarhus University Hospital, Aarhus, Denmark, January 2006 Cortical thickness analysis in normal development and neuropathology

103. Cure Autism Now Workshop, UCLA, Los Angeles, January 2006 MRI Study of Normal Brain Development

104. Cure Autism Now Workshop, UCLA, Los Angeles, January 2006 The Long Road … The Tourette Syndrome Association’s Neuroimaging Initiatives

28 28

105. Queen’s University, Kingston, February 2006 Computational analysis of 3D brain image data: Methods and applications

106. National institutes of Health, Bethesda, USA, March 2006 Linking large-scale brain imaging databases

107. University of Nottingham Purkinje Lecture, Nottingham, May 2006, Computational analysis of 3D brain image data: Methods and applications

108. University of Paris, Paris, May 2006, NIH MRI Study of Normal Brain Development

109. U.K. Medical Research Council, London, June 2006 Large –scale brain imaging databases

110. University College, Dublin, July 2006, NIH MRI Study of Normal Brain Development

111. University of Edinburgh, Edinburgh, September 2006, Imaging of pediatric brain development

112. St. James Literary Society, Montreal, September 2006, The hitch-hiker’s guide to the brain: Hi-tech imaging of the living human brain

113. Tohoku University, Sendai, Japan, October 2006, Cortical thickness degeneration in normal aging and degenerative disease

114. University of California, Davis, November 2006, The NIH MRI study of Normal Pediatric Development

115. National Brain Research Centre, Delhi, December 2006, Cortical thickness growth and degeneration in development, normal aging and degenerative disease

116. Rotman Institute, University of Toronto, Toronto, January 2007, Structural imaging of normal brain development and neuropathology

117. Keynote Lecture: 2nd International Conference on Neuroinformatics, Havana, February 2007, Structural imaging of normal brain development and neuropathology

118. MUHC Annual Retreat, Mont Tremblant, March 2007 Structural and functional neuroimaging of the developing brain

119. University of Buenos Aires, International Symposium on Brain Imaging, April 2007, Cortical thickness analysis of development, normal aging and dementia

120. CANARIE Annual Meeting, April 2007 Brain Mapping: Towards a global brain imaging research network

121. 23rd International Symposium on Cerebral Blood Flow, Metabolism and Function (Brain’07), Educational Course, Osaka, Japan, May 2006, The role of MRI in drug development

122. University of Montreal, St. Justine Hospital 50th AnniversarySymposium on Neurodevelopment May 2006, Structural imaging of normal brain development

123. McGill University Mini-Science Series, May 2006, The visible brain: Imaging the structure and function of the living human brain

124. CANARIE Network-Enabled Platforms Workshop, June 2007 Brain Mapping: Towards a global

29 29 brain imaging research network

125. Institute for International Research, Imaging in Clinical Trials Symposium, San Francisco, September 2007 Progress, Next Steps & FAQs in Designing Imaging Databases

126. IBM Industry Solutions Laboratory, New York, November 2007, Global Brain Imaging Research Network

127. 4th International Symposium on Multiple Sclerosis, Teheran, November 2007, Cortical atrophy in multiple sclerosis

128. Iranian National Centre for Addiction Studies (INCAS), Teheran, November 2007, Neuroimging: Scientific Trends, BIC Infrastructure, Opportunities for Collaboration

129. Indian Statistical Institute, Jubilee Symposium Visionary Lecture Series on Neuroscience and Brain Mapping, Kolkata, November 2007, Introduction to brain imaging methods

130. Indian Statistical Institute, Jubilee Symposium Visionary Lecture Series on Neuroscience and Brain Mapping, Kolkata, November 2007, MRI imaging of brain growth and development

131. Indian Statistical Institute, Jubilee Symposium Visionary Lecture Series on Neuroscience and Brain Mapping, Kolkata, November 2007, Cortical surface analysis in development, aging and disease

132. Hanyang University, Seoul, December 2007, Cortical thickness analysis in normal development

133. Hanyang University, Seoul, December 2007, Structutral MRI analysis in aging and disease

134. McMaster University, Hamilton, January 2008, Cortical thickness MRI analysis of brain development

135. Max Planck Institute of Human Cognitive and Brain Sciences, Leipzig, January 2008, MRI analysis of cortical morphology in development and degeneration

136. Rotman Institute Symposium on Neuroimaging in Dementia: Keynote Lecture University of Toronto, Toronto, March 2008, History of MRI and PET Methodology Advances to Study Dementia

137. Latin American Brain Mapping Network Symposium, University of Havana, March 2008, Brain Mapping Networks

138. von Economo Symposium, University of Trieste, Italy, March 2008, Cortical growth and degeneration assessed wth MRI

139. International Neuroinformatics Coordinating Facility (INCF) Symposium: Databasing and Modeling the Brain, University of Stockholm, Sweden, September 2008 Cortical anatomical networks identified by structural MRI

140. International Conference on Neuroimaging and Developmental Disorders, Dubrovnik, Croatia, September 2008 NIH MRI Study of Normal Brain Development

30 30 141. International Conference on Neuroimaging and Developmental Disorders, Dubrovnik, Croatia, September 2008 Neurogenomics, neuroimaging and pharmacogenomics

142. Neuromaging Training Workshop, Dubrovnik, Croatia, September 2008 Fully-automated brain image analysis

143. Neuromaging Training Workshop, Dubrovnik, Croatia, September 2008 Image registration and segmentation

144. Neuromaging Training Workshop, Dubrovnik, Croatia, September 2008 Cortical thickness analysis in pediatric brain

145. King’s College London, U.K., September 2008, Cortical thickness analysis in development and disease

146. University of Queretaro, Mexico, NIH MRI Study of Normal Brain Development, October, 2008

147. Centro de Investagacio en Matematicas (CIMAT), Guanajuato, Mexico, October 2008 Cortical anatomical networks revealed by structiural MRI

148. Powering Innovation: A National Summit, Toronto, November 2008 Global Brain Imaging Research Network

149. IBIS Autism Center of Excellence Workshop, January 2009, Current status of IBIS network data collection

150. Pacific Rim Neuroscience Network, Hawaii, April 2009 Human cortical n etworks assessed by structural MRI

151. CANARIE Network-Enabled Platform Synergy Workshop, April 2009 CBRAIN, Canadian Brain Imaging Research Network

152. 2nd International Conference on Brain Imaging and Genomics, Dubrovnik, Croatia, May 2009 Longitudinal study of normal brain development

153. 2nd International Conference on Brain Imaging and Genomics, Dubrovnik, Croatia, May 2009 Cortical thickness analysis in pediatric brain

154. BIRS: Keith Worsley workshop on Computational Modeling of Brain Dynamics: from stochastic models to Neuroimages, Banff , June 2009 Anatomical Brain Atlases

155. National Research Council, Ottawa, September 2009 CBRAIN - Canadian Brain Imaging Network

156. CHI Conference on Accelerating Innovation, Boston October 2009 – Brain Mapping

157. CYBERA Summit on High performance Computing, Banff, October 2009 CBRAIN - Canadian Brain Imaging Network

158. National University of Singapore, Singapore, November 2009 Quantitative structural MRI of neurodevelopment

31 31 159. Compute Canada Annual Meeting, Toronto, November 2009 CBRAIN - Canadian Brain Imaging Network

160. Third Vogt-Brodmann Symposium, Juelich, December 2009 Maturation of the cerebral cortex and neuroimaging

161. Duke-NUS Medical School, Singapore, April 2010 Cortical morphometry in development and degeneration

162. Cognitive Neuroscience Symposium on Dysfunctional Imaging, Montreal, April 2010 Network modeling of anatomical and functional neuroimaging data

163. 4th McGill Global Health Conference, Montreal, April 2010, Towards a global neuroimaging network

164. Keynote Lecture, MICCAI, Beijing, China, September 2010, Network modeling of cortical anatomy

165. Beijing Normal University, Beijing, China, September 2010, Imaging of brain anatomical networks

166. Korean Dementia Network, Seoul, Korea, September 2010, Multi-centre brain imaging networks in neurodegeneration

167. KISTI Korean High Performance Computing Centre, Daejong Korea, September 2010, GBRAIN, an international brain imaging network

168. Université de Montréal, Montreal, October, 2010 Network analysis of cortical anatomy in neurodevelopment and neuroanatomy

169. UK-Germany-Canada Workshop on Neuroimaging of Neurodegenerative Disorders, Montréal, November, 2010 Multi-centre brain imaging networks in neurodegeneration

170. Pacific Rim Neuroscience Network conference on New Horizons in Brain Imaging: A Focus on Brain Networks and Connectivity, Hawaii, December, 2010 MRI analysis of neuroanatomical networks

171. European Parliament, January, 2011 CBRAIN and LONI: Multi-centre networks for the study of neurodegenerative disorders

172. University of Vermont, Burlington, January, 2011 Neuroanatomical networks in neurodevelopment and neuroanatomy

173. Cardiff University, Cardiff, February, 2011 Network analysis of cortical anatomy in neurodevelopment and neuroanatomy

174. Erasmus University, Rotterdam, February, 2011 Pediatric image processing at the MNI

175. American Academy of Neurology, Hawaii, April, 2011, Imaging Brain Networks and Connections

176. Pfizer, Groton, Connecticut June, 2011 Imaging of brain networks

177. High Performance Computing Symposium (HPCS 2011), Montreal, June 2011, CBRAIN: Canadian Neuroinformatics Platform

178. Brain Connectivity Workshop, Montreal, June, 2011 Life span changes in structural connectivity/morphology

32 32

179. Annual Meeting of the Organization for Human Brain Mapping (HBM2011), Quebec City, June , 2011, Educational course: MRI in the developing brain

180. Annual Meeting of the Organization for Human Brain Mapping (HBM2011), Quebec City, June , 2011, Anatomical mapping: Structural network analysis in the aging brain

181. Canadian Data Research Summit, Ottawa, September 2011, CBRAIN: Canadian Neuroinformatics Platform

182. Keynote Lecture, MICCAI, Toronto, September 2011, CBRAIN: Canadian Neuroinformatics Platform

183. Max Planck Symposium on The Neuroscience of Language Development: Structure and Function, Leipzig, November 2011, Brain Structural Connectivity

184. McGill Cutting Edge Lecture Series, Montreal, January 2012, Non-invasive mapping of the human brain

185. CFI-UBC AAAS Satellite meeting on Modern Technologies in Canadian Research, Vancouver, January 2012, CBRAIN: Canadian Neuroinformatics Platform

186. RBIQ 4th Annual Scientific Day, February 2012, Structural network analysis in neurodevelopment and neurodegeneration

187. OutGRID: European Symposium on Research Applications of Grid Computing, Geneva, February 2012, CBRAIN: Canadian Neuroinformatics Platform

188. Max Planck Symposium on In-vivo Brodmann Mapping of the Human Brain, Leipzig, April 2012, Anatomical brain models for mapping structural connectivity

189. Jülich Research Centre, Jülich, April 2012, CBRAIN: A global portal for neuroinformatics research

190. Cornell University, New York, May 2012, Structural connectivity in neurodevelopment and neurodegeneration

191. Translational Imaging in Alzheimer’s Disease (TRIAD) workshop, Montreal, May 2012 Structural connectivity in AD patients and mouse models

192. International Meeting For Autism Research (IMFAR), Toronto, May 2012 Structural connectivity in in neurodevelopment

193. International Neuroinformatics Coordinating Facility (INCF) Symposium, Vancouver, May 2012, CBRAIN: A global portal for neuroinformatics research

194. International Workshop on Translational MRI in Alzheimer’s Disease Research, Montreal, May 2012, Changes in structural brain network topology in normal aging and Alzheimer’s Disease

195. Brain Connectivity Workshop, Chengdu, June 2012, Structural connectivity in brain revealed by correlation of cortical morphology

196. Keynote Lecture, International Conference on Human Brain Mapping, Beijing, June 2012, Networks of anatomical covariance

197. Ontario Brain Institute, Toronto, August 2012, Analysis of large datasets

33 33

198. International Neuroinformatics Coordinating Facility (INCF) Workshop, Munich, September 2012, CBRAIN: A global portal for neuroinformatics research

199. National Institute of Aging, Baltimore, September 2012, Structural network analysis is Alzheimer’s Disease

200. National Institute of Aging, Baltimore, September 2012, The Big Brain: Ultra high-resolution 3D brain atlas

201. Jülich Research Centre, Jülich, January 2013, Brain Mapping: The shotgun marriage of neuroscience and computer science

202. National Brain Research Centre, Delhi, February 2013, Networks of anatomical covariance

203. INCF Workshop on Brain Atlases and Templates, Seattle, June 2013, The Big Brain: An ultra-high resolution 3D digital brain atlas

204. Beijing Normal University, Beijing, June 2013, Structural and functional connectivity in development and neurodegeneration

205. Chinese Institute of Automation, Beijing, June 2013, The Big Brain: An ultra-high resolution 3D model of human neuroanatomy

206. European Brain and Behaviour Society, Munich, September 2013, Structural network analysis in brain development

207. Second Translational Imaging in Alzheimer’s Disease (TRIAD) workshop, Montreal, September 2013, The Canadian Brain Research Network (CBRAIN) and standardization of image processing

208. Data Harmomization workshop, Toronto, October 2013, CBRAIN and LORIS

209. William Feindel Lecture, Quebec Brain Imaging Network (RBIQ/QBIN) 8th Annual Synposium, Montreal, January, 2014 Structural and functional connectivity in neurodevelopment and neurodegeneraiton

34 34 STUDENT SUPERVISION

Summer students

1. Avery Nathens, Computerized atlas of rat brain (1988)

2. Shahram Partovi, Computerized atlas of monkey brain (with Dr. M. Guttman) (1989)

3. Sevan Ortaaslan,Oxygen/Glucose coupling in normal brain (1989)

4. Michael Langer, 3-D image processing (1989)

5. Shyan Ku, Anatomical-functional correlation (1989)

6. Claire Jegouzo, 3-D image processing (1993)

7. Anas Orfali, functional MRI stimulus presentation (1994)

8. Reza Forghani MRI analysis of multiple sclerosis (1996)

9. Jacqueline Pronk 3D image interpolation (2000)

10. Danielle Tisserand MRI analysis of Alzheimer’s Disease database (2001)

11. Jussi Tohka Partial Volume Correction in MRI Segmentation (2002)

12. James McKinney Pipeline Analyis of MRI databases (2005)

13. Rachel Martin L’Effet du vieillisement sur l’interférence dans la tache de Stroop (2007)

14. Antoine Leuzy Behavioral data collection in normal older subjects (2007)

M.Sc. 1. Sayed Jovkar Optimization of sampling schedules for kinetic PET MSc in Neurology/Neurosurgery (1988)

2. Micheline Kamber Automatic Detection of multiple sclerosis lesions in magnetic resonance images of the human brain M.Sc. in Computer Science at Concordia University (1991)

3. Andrew Lukban Evaluation of SPECT/MRI registration error from the Internal Landmark Matching technique M.Sc. in Medical Physics, co-supervised with Dr. G. Dean (1994)

4. Weiqun Gu Automated tracer-independent MRI/PET image registration M.Sc. in Electrical Engineeering (1996)

5. Vasken Kollokian Performance analysis of automatic techniques for tissue classification in magnetic resonance images of the human brain M.Sc. in Computer Science at Concordia University (1996)

6. Remi Kwan An extensible MRI simulator for quantitative evaluation of image processing and classification methods M.Sc. Biomedical Engineering, co-supervised with Dr. B. Pike (1997)

7. John Sled A non-parametric method for automatic correction of intensity non-uniformity in MRI data M.Sc. in Biomedical Engineering (1997)

35 35 8. Hing Cheung Chui Three-dimensional registration and voxel-based analysis in magnetic resonance imaging M.Sc. in Computer Science (1998)

9. Mark Wolforth A system for the acquisition and analysis of blood data for positron emission tomography M.Sc. in Biomedical Engineering (1998)

10. Chris Cocosco Automatic generation of training data for brain tissue classification from MRI M.Sc. in Electrical Engineering (2002)

11. Vivek Singh Partial Volume Correction in MRI Segmentation M.Sc. in Electrical Engineering (2005)

12. Oleg Ivanov Automated tissue classification of large image databases M.Sc. in Biomedical Engineering (2006)

14. Sarah Assadian MRI ligand development M.Sc. in Neurology/Neurosurgery (2007)

15. Kelvin Mok Simulation of MRI data M.Sc. in Biomedical Engineering (2004-date)

16. Jonathan Lau Mouse brain stereotaxic MRI analysis pipeline in Biomedical Engineering (2005-date)

17. Hosung Kim Cortical thickness MRI analysis in epilepsy (2005-date, co-supervised with Dr. Andrea Bernasconi)

18. Pierre Besson Structural MRI analysis in epilepsy (2006-date, co-supervised with Dr. Andrea Bernasconi)

19. Jahyun Koo Accelerating a medical 3D brain MRI analysis algorithm using a high-performance reconfigurable computer (2006-20007, co-supervised with Dr. Warren Gross)

Ph.D.

1. Louis Collins 3D model-based segmentation of individual brain structures from magnetic resonance imaging data Ph.D. in Biomedical Engineering (1995)

2. David MacDonald Surface identification and matching in three-dimensional images Ph.D. in Computer Science (1998, co-supervised with Dr. David Avis)

3. Olivier Rousset In-vivo correction of partial volume effects in positron emission tomography Ph.D. in Computer Science, U. de Lyon (1998)

4. Yilong Ma A 3-D PET simulation system for quantitative functional imaging Ph.D. in Biomedical Engineering (2001)

5. Mary M. Chiavaras The orbitofrontal cortex: Sulcal anatomy and cytoarchitectonic correlations Ph.D. in Neurology and Neurosurgery (2001, co-supervised with Dr. Michael Petrides)

6. Serge Dumoulin Motion mechanisms and cortical areas in human vision: Psychophysics and fMRI Ph.D. in Neuroscience (2003, co-supervised with Drs. Robert Hess and Curtis Baker)

7. Steven Robbins Anatomical standardization of the human brain in euclidean 3-space and on the cortical 2-manifold Ph.D. in Computer Science (2003) Co-supervised with Dr. Susan Whiteside

36 36 8. Jason Lerch Cortical Thickness: Anatomy, Methodology and Epidemiology Ph.D. in Neurology/Neurosurgery (2005)

9. Oliver Lyttelton Meta-analysis of multimodal brain imaging data Ph.D. in Biomedical Engineering (2010)

10. Yasser Ad-Dab’bagh M.D. Cortical thickness analysis in pediatric psychiatry populations Ph.D in Psychiatry (2002 - date, co-supervised with Dr. Eric Fombonne)

11. Zhang (John) Chen Graph theory of structural connectivity Ph.D. in Biomedical Engineering (2011)

12. Najmeh Khalili Structural-functional imaging of stress Ph.D. in Neuroscience (2009, co-supervised with Dr. Jens Pruessner)

13. Maxime Boucher Cortical brain development Ph.D. in Computer Science (2005-2011, co-supervised with Dr. Kalim Siddiqi)

14. Xuntao Yin, Genetic influence on brain network properties (2010-date)

15. Francois Chouinard Genetic influence upon functional and structural connectivity (2011-date, co- supervised with Dr. Pierre Bellec)

16. Brocke Addison Microstructural basis of cortical thickness changes due to learning (2012-date)

17. Xiaoling Feng Multivariate analysis of neuroimaging data in Alzheimer’s Disease (2013-date)

18. Sebastian Urchs Functional and structural connectivity in neurodevelopment (2013-date, co- supervised with Dr. Pierre Bellec)

Ph.D. Review Committee

1. Stephen Strother - Quantitation in Positron Emission Tomography

2. Christopher Henri - 3-D image reconstruction of cerebral vasculature

3. Sean Marrett - PET studies of oxygen metabolism in visual cortex

4. Jeanne Talbot - Neurophysiogy of pain processing, U. of Montreal

5. Jean-Mary Marat - Functional neuroanatomy of musical perception, McGill

RESEARCH FELLOWS

1. Curt Beil M.D. Human brain atlas (1987-88)

2. Jaime Torrescorzo M.D. Human brain atlas (with Dr. J.-G. Villemure) (1989)

3. Wei Lin-tong Ph.D. 3-D imaging of rat brain (with Drs. A. Beaudet, B. Jones) (1989-90)

4. Youpu Zhang Ph.D. MRI-constrained PET image reconstruction (1990-1994)

5. Cécile Sorlié Ph.D. 3-D Human brain atlas (March 1993-1995)

6. Jose Espinoza M.D. MRI/PET in neurosurgical planning in epilepsy (July 1993-1994)

37 37

7. David Reutens M.D. 3-D MRI/PET imaging in epilepsy (March 1993-1995)

8. Xiaolong Ouyang Ph.D. MRI/PET imaging analysis (September 1993-1994)

9. Colin Holmes Ph.D. MRI neuroanatomy reference atlas (October 1993-1995)

10. Alex Zijdenbos Ph.D. Automated segmentation of MS lesions in MRI (1994-1997)

11. Georges LeGoualher Ph.D. Automated extraction of cortical sulci from 3D MRI (1997-2001)

12. Noor Kabani Ph.D. Quantitative neuroanatomy in normal brain and FLI (1995-2000)

13. Louis Collins Ph.D. Automated 3D segmentation of brain regions (1997-2000)

14. Alexander Thiel, Partial Volume Correction of PET data (2000-01)

15. Rik Stokking Ph.D. MRI Segmentation (2000-2001)

16. Barry Bedell Ph.D. MRI ligand development (2000-2004)

17. Anthonin Reilhac Ph.D. Partial Volume Correction of PET data (2000-2002)

18. June Sik Kim Ph.D. Automated extraction of cortical features from 3D MRI (2002-2004)

19. Richard Webster M.D. MRI studies in children with SLI (2002-04, with Dr. Michael Shevell)

20. Andrew Goertzen Ph.D. Animal PET methodology (2003-2006)

21. Pedro Rosa-Neto M.D. PET imaging of altanserin (2004-2008)

22. Claude Lepage Ph.D. High-performance computational analysis of brain structure (2005-date)

23. Cherine Fahim Ph.D. Genetic influence on development: Quebec Newborn Twin Study (2004-2009)

24. Yong He Ph.D. Anatomical-functional connectivity in Alzheimer’s Disease (2005-2008)

25. Uicheul Yoon Ph.D. Heritability of cortical anatomy in Quebec Newborn Twin Study (2006-2010)

26. Krista Hyde Ph.D. Cortical thickness analysis in auditory processing and autism (2006-2010)

27. Pierre Bellec Ph.D. Statistical analysis methods development using simulated fMRI (2006-2010)

28. Sharif Karama M.D. Neural correlates of IQ (2007-date)

29. Junki Lee Ph.D. Cortical surface analysis using MRI (2007-date)

30. Cédric Clouchoux Ph.D. Cortical surface atlas from 3D MRI (2007-2010)

31. Gaolang Gong Ph.D. Network analysis of cortical morphology (2008-2010)

32. John Lewis Ph.D. Cortical morphological analysis in autism (2008-date)

33. Linzhong Fan Ph.D. Structural mapping of the human cerebellum (2008-2009)

38 38 34. Xiaoxin Guo Ph.D. Artifact correction in pediatric MRI data (2008-2009)

35. Bertha Gonzales Ph.D. Imaging of pediatric brain development (2009-2010)

36. Budhachanda Khundrakpam Ph.D. Network Analysis of cortical morphology (2009-date)

37. Nataliya Portman Ph.D. Mathematical modeling of neuroanatomical variability (2010-date)

38. Andrew Reid Ph.D. Network Analysis of cortical morphology (2010-date)

39. Lu Zhao, Ph.D. Cortical volume analysis (2010-date)

40. Paule-Joanne Toussaint Multivariate modeling of Alzheimer’s disease (2013-date)

RESEARCH ASSOCIATES

1. Sean Marrett Image registration (1985-2002)

2. Peter Neelin Data analysis (1985-2000)

3. Louis Collins Image segmentation (1997-2000)

4. Alex Zijdenbos Data Analysis (1997 – 2008)

5. Rozie Arnaoutelis Pediatric Database Coordination (2002-2008)

6. Samir Das Pediatric Database Site Support (2002-date)

7. Reza Adalat Database management (2001-2006)

8. Andrew Cordery Database management (2002-2004)

9. Sebastian Muehlboeck Database management (2003-2008)

10. Jonathan Harlap Database management (2003-2008)

11. David Brownlee Database Management (2004-date)

12. Marc Rousseau Canadian Brain Imaging Network (CBRAIN) (2008-date)

13. Pierre Rioux Canadian Brain Imaging Network (CBRAIN) (2008-date)

14. Tarek Sherif, Canadian Brain Imaging Network (CBRAIN) (2008-date)

15. Nicolas Kassis, Canadian Brain Imaging Network (CBRAIN) (2010-2012)

16. Tien-Duc Nguyen, Canadian Brain Imaging Network (CBRAIN) (2010-2012)

17. Rosanne Aleong, Autism Database Coordination (2008-2010)

18. Angela McCloskey Canadian Brain Imaging Network (CBRAIN) (2009-date)

19. Zia Mohaddes Database management (2009-date)

20. Lindsay Lewis Cortical thickness analysis (2011-date)

39 39

21. Penelope Ksostopoulos Autism project management (2010-date)

22. Mia Petkovic Alzheimer’s Disease database management (2011-2014)

23. Cecile Madjar Alzheimer’s Disease database management (20110-date)

24. Najmeh Khalili Multi-model neuroimaging methodologies (2014-date)

VISITING SCIENTISTS

1. Dr. David Hawkes, Guy’s and Thomas’ Hospital, London U.K. (March 1992 - September 1992)

2. Dr. John Crossman, Guy’s and Thomas’ Hospital, London U.K. (November 1992)

3. Dr. Graeme O’Keefe, Medical Physics, U. of Melbourne, Australia (January 1993 - March 1993)

4. Prof. Shuqian Luo, Professor of Computer Science, Zhenzhou U., China (Apr. 1993 - Oct. 1993)

5. Dr. John Absher, Bowman-Gray Medical School, USA (July 1993 - Aug 1993)

6. Dr. David Banks, Florida State University, 3D visualization of MRI/PET data (2003)

7. Dr. Ryoi Goto, Tohoku Universty, Sendai, Japan Study of human aging using structural MRI (2003)

8. Dr. Jean-Francois Mangin, INSERM, Paris, 3D reconstruction of cortical sulci from MRI (2003-4)

9. Dr. Cheng Wang, Shanghai University, China, Extraction of brain from 3D cranial MRI (2006)

10. Dr. Simon Eskilden, Aalborg University, Denmark, Cortical surface extraction from MRI (2006)

11. Dr. Michael Ewers, Ludwig Maximillian University, Germany, Cortical thickness analysis in Alzheimer’s Disease (2007)

12. Dr. Irene Scholz, Juelich Brain Research Centre, Germany MRI analysis of aging brain (2007)

13. Dr. Hartmut Mohlberg, Juelich Brain Research Centre, Germany Image analysis of digital histology (2007)

14. Dr. Pedro Valdes, Yasser Aleman, Karel Morales, Cuban Neuroscience Centre, Havana, Cuba Brain Image Acquisition and Analysis methods (2007)

15. Dr. Jiang Chen, Shanghai University, China, Resting-state fMRI analysis (2007)

16. Dr. Andrew Reid, U. of Nijmegen, Netherlands, Cortical network analysis in white-matter vascular disease (2007)

17. Dr. Eini Niskanen, U. of Kuopio, Finland, Cortical thickness analysis in Alzheimer’s Disease (2007)

18. Dr. Andew Simmons, Kings College London, UK Databasing of Innomed Alzheimers Project (2007)

19. Dr. Michela Pievani, U. of Brescia, Italy, Cortical thickness analysis in Alzheimer’s Disease (2007)

20. Dr. Jose Manjon, U. of Valencia, Spain, Multivariate statistical analysis of MRI images (2008)

40 40

21. Dr. Lu Zhao, Technical University, Tampere, Finland, Cortical morphological analysis (2009)

22. Dr. Simon Eickhoff, Universtatklinikum Aachen, Germany, Meta-analysis of neural connectivity (2010)

23. Jens Brauer, Max-Planck Institute, Leipzig, Germany, Anatomical connectivity in developing brain (2010)

24. Yunyi Yan, Xidian University, Xi’An, China, Tissue classification of structural MR images (2010- 11)

25. Megha Sharda, National Brain Research Centre, New Delhi, Structural connectivity in autism, Summer 2013

26. Ni Shu, Beijing Normal University, Structural and functional connectivity in neurodegenerative disease, 2013-14

41 41 1. EXTERNAL SCIENTIFIC COLLABORATIONS

1. Drs. John Mazziotta (UCLA), Arthur Toga(UCLA), Peter Fox(U. of Texas) Human Brain Mapping Consortium Exchange of normative data and software for anatomical and functional neuroanatomical mapping of human brain.

2. Dr. Karl Zilles University of Düsseldorf Anatomical brain mapping. Exchange of students, fellows, software.

3. Dr. Ryuta Kawashima Institute of Development, Aging and Cancer (IDAC), Sendai, Japan Probabilistic neuroanatomy atlas ; exchange of students, software and data

4. Dr. Jong-Min Lee Hanyang University, Seoul, Korea 3-D MRI-based quantitative analysis of human cerebral cortex. Exchange of sfotware, fellows

5. Dr. Hilleke Hulshoff-Pol University of Utrecht 3-D MRI-based quantitative analysis of psychiatric disorders. Exchange of software, fellows

6. Dr. Judith Rapoport National Institute of Mental Health 3-D MRI-based quantitative analysis of psychiatric disorders. Exchange of data, joint research

7. Dr. Christian Spenger, Karolinska Institute, Sweden Database of Alzheimer’s Disease MRI

8. Dr. Harald Hampel, Ludwig-Maximillian University, Munich, Cortical thickness in Alzheimer’s Disease

9. Dr. Pedro Valdes-Sosa, University of Havana EEG database, cortical morphology analysis

10. Dr. Jorge Riera, Tohoku University, Sendai, Japan Integration of fMRI, cortical surface, EEG data in visual processing

11. Dr. Prasun Roy, National Brain Research Centre, New Delhi, India Indian Brain Imaging Research Network

12. Dr. Mark Ellisman, University of California, San Diego High bandwidth collaboratory of 3D brain data

13. Dr. Ivica Kostovic, University of Zagreb, Croatia Pediatric brain image analysis

14. Dr. James Hudziak, University of Vermont, Pediatric brain imaging-genomics analysis

42 42 Bibliography - Peer-reviewed articles, published or in press

1. Isaacs N, James R, Niall N, Bryant-Wood G, Dodson G, Evans AC, North ACT (1978) Relaxin and its structural relationship to insulin Nature 271(5642): 278–81

2. Cooke BE and Evans AC (1983) A phantom to assess quantitative recovery in a positron tomography J Comput Assist Tomogr 7(5): 876–80

3. Yamamoto YL, Ochs R, Amman W, Meyer E, Evans AC, Cooke BE, Sako K, Gotman J, Feindel W, Diksic M, Thompson CJ, Robitaille Y (1984) Changes of energy metabolism and regional cerebral blood flow studied by positron emission tomography in the interictal phase of partial epilepsy Acta Neurochirurgica Suppl 33: 35–46

4. Cooke BE, Evans AC, Fanthome EO, Alarie RA, Sendyk AM (1984) Performance figures and images for the Therascan 3128 Positron Emission Tomograph IEEE Trans. Nucl. Sci., NS-31: 640–4

5. Tyler JL, Yamamoto YL, Diksic M, Theron J, Villemure J-G, Worthington C, Evans AC, Feindel W (1986) The pharmacokinetics of super-selective intra-arterial and intravenous C-11 BCNU evaluated by PET J Nucl Med 27(6): 775–80

6. Evans AC, Diksic M, Yamamoto YL, Kato A, Dagher A, Redies C, Hakim A (1986) The effect of vascular activity in the determination of rate constants for the uptake of F-18 labelled 2-fluoro-2- deoxy-D-glucose: Error analysis and normal values in older subjects J Cereb Blood Flow Metabol 6: 724–38

7. Hakim AM, Pokrupa RP, Villanueva J, Diksic M, Evans AC, Thompson CJ, Meyer E, Yamamoto YL, Feindel W (1987) The effect of spontaneous reperfusion on metabolic function in early human cerebral infarcts Ann Neurol 21: 279–89

8. Matsuda H, Nakai H, Jovkar S, Diksic M, Evans AC, Meyer E, Redies C Yamamoto YL (1987) An alternative approach to estimated lumped constant in the deoxyglucose model: Simulation and validation J Nucl Med 28(4): 471–80

9. Redies C, Matsuda H, Diksic M, Evans AC, Meyer E, Gjedde A, Yamamoto YL (1987) Double- label autoradiographic deoxyglucose method for sequential measurement of regional cerebral glucose utilization. Theory and apparent rate constants for F-18 fluorodeoxyglucose in rat brain grey matter Neuroscience 22(2): 601–19

10. Tyler JL, Diksic M, Villemure J-G, Evans AC, Meyer E, Yamamoto YL, Feindel W (1987) Metabolic and hemodynamic evaluation of gliomas using positron emission tomography J Nucl Med 28: 1123–33

11. Ochs RF, Gloor P, Tyler JL, Wolfson T, Worsley K, Andermann F, Diksic M, Meyer E, Evans AC (1987) Effect of generalized spike and wave discharge upon glucose metabolism measured by PET Annals of Neurology 21: 458–64

12. Thompson CJ, Dagher A, Meyer E, Evans AC (1986) Imaging performance of a dynamic positron emission tomograph: Positome IIIp IEEE Trans Med Imaging MI-5(4): 183–98

13. Levy DE, Sidtis JJ, Rottenberg DA, Jarden JO, Strother SC, Dhawan V, Ginos JZ, Tramo MJ, Evans AC, Plum F (1987) Differences in cerebral blood flow and glucose utilization in vegetative vs locked-in patients Ann Neurology 22: 673–82

14. Meyer E, Yamamoto YL, Evans AC, Tyler JL, Diksic M, Feindel W (1987) Radiation dose to upper 43 43 airways from inhaled oxygen-15 labelled carbon dioxide J Nucl Med 28: 234–9

15. Phillips PC, Dhawan V, Strother SC, Sidtis JJ, Evans AC, Rottenberg DA (1987) Reduced cerebral glucose metabolism and increased brain capillary permeability following high-dose methotrexate chemotherapy: a positron emission tomography study Ann Neurology 21: 59–63

16. Evans AC, Beil C, Marrett S, Thompson CJ, Hakim AM (1988) Anatomical-functional correlation using an adjustable MRI-based region-of-interest atlas with positron emission tomography J Cereb Blood Flow Metabol 8 (4): 513–30

17. Andreasen N, Carson R, Diksic M, Evans AC, Farde L, Gjedde A, Hakim A, Lal S, Nair N, Sedvall G, Tune L, Wong D (1988) Schizophrenia, positron tomography and dopamine D2 receptors in human neostriatum Schizophrenia Bulletin 14(3): 471–84

18. Redies C, Hoffer LJ, Beil C, Marliss EB, Evans AC, Lariviere F, Marrett S, Meyer E, Diksic M, Hakim AM (1988) Generalized decrease in brain glucose metabolism during fasting in man studied by PET Am J Physiol 256 (EM19): E805–10

19. Dhawan V, Moeller JR, Strother SC, Evans AC, Rottenberg DA (1989) Effect of selecting a fixed dephosphorylation rate on the estimation of rate constants and rCMRGlu from dynamic [18F] fluorodeoxyglucose/PET data J Nucl Med 30(9): 1483–8

20. Jovkar S, Evans AC, Nakai H, Diksic M, Yamamoto YL (1989) Influence of temporal sampling on the accuracy of parameter estimation in the deoxyglucose method Phys Med Biol 34(7): 895–908

21. Berkovic SF, Carpenter S, Evans AC, Karpati G, Shoubridge EA, Andermann F, Meyer E, Tyler JL, Diksic M, Arnold DL, Wolfe LS, Andermann E, Hakim AM (1989) Myoclonus epilepsy and ragged- red fibres (MERRF): A clinical, pathological, biochemical, magnetic resonance spectrographic and positron emission tomographic study Brain 112: 1231–60

22. Ranger NT, Thompson CJ, Evans AC (1989) The application of a masked orbiting transmission source for attenuation correction in PET J Nucl Med 30(6): 1056–68

23. Hakim AM, Evans AC, Berger L, Kuwabara H, Worsley K, Marchal G, Beil C, Pokrupa R, Marrett S, Diksic M, Meyer E, Gjedde A (1989) The effect of Nimodipine on the evolution of human cerebral infarction studied by PET J Cereb Blood Flow Metabol 9(4): 523–34

24. Marrett S, Evans AC, Collins DL, Peters TM (1989) A volume of interest (VOI) atlas for analysis of neurophysiological image data Proceedings of the International Society of Optical Engineering (SPIE): Medical Imaging III: 467–77

25. Thompson CJ, Ranger N, Evans AC (1989) Simultaneous transmission and emission scans in positron emission tomography IEEE Transactions on Nuclear Science 37(1): 1011–6

26. Evans AC, Marrett S, Collins DL, Peters TM (1989) Anatomical-functional correlative analysis of the human brain using three-dimensional imaging systems Proceedings of the International Society of Optical Engineering (SPIE): Medical Imaging III: 264–74

27. Henri C, Collins DL, Peters TM, Evans AC (1989) Three-dimensional interactive display of medical images for stereotactic neurosurgery planning Proceedings of the International Society of Optical Engineering (SPIE): Medical Imaging III: 67–74

28. Kuwabara H, Evans AC, Gjedde A (1990) Michaelis-Menten constraints improved cerebral glucose metabolism and regional lumped constant measurements with F18-fluorodeoxyglucose J Cereb Blood Flow Metabol 10(2): 180–9

44 44

29. Matthews P, Evans AC, Andermann FE, Hakim AM, Andermann E(1989) Local cerebral glucose metabolism differs in the adult and rigid juvenile forms of Huntington’s disease J Pediatric Neurology 5(6): 353–6

30. Teitelbaum JS, Zatorre RJ, Carpenter S, Gendron D, Evans AC, Gjedde A, Cashman NR (1990) Neurological sequelae of domoic acid intoxication due to ingestion of contaminated mussels New England Journal of Medicine 322: 1781-7

31. Gjedde A, Kuwabara H, Evans AC (1990) Metabolic brain imaging: Direct regional measurement of transfer coefficients and lumped constant Acta Radiologica Supplementum 374: 117-21

32. Archer DP, Labrecque P, Tyler JL, Meyer E, Evans AC, Villemure JG, Casey WF, Diksic M, Hakim AM, Trop D (1990) Measurement of cerebral blood flow and volume with positron emission tomography during isoflurane administration in the hypocapnic baboon Anaesthesiology 72(6): 1031-7

33. Evans AC, Peters T, Collins DL, Henri C, Marrett S, Pike B, Dai W (1990) 3-D correlative imaging and segmentation of cerebral anatomy, function and vasculature IEEE Trans Eng Med Biol 12(3): 297-8

34. Evans AC, Marrett S, Torrescorzo J, Ku S, Collins DL (1991) MRI-PET correlative analysis using a volume of interest (VOI) atlas J Cereb Blood Flow Metabol 11(2): A69–78

35. Evans AC, Thompson CJ, Marrett S, Meyer E, M Mazza M (1991) Performance characteristics of the PC-2048: A new 15-slice encoded-crystal PET scanner for neurological studies IEEE Transactions on Medical Imaging 10(1): 90–8

36. Badger J, Harris MR, Reynolds CD, Evans AC, Dodson EJ, Dodson GG, North ACT (1991) Structure of the pig insulin dimer in the cubic crystal Acta Cryst. B47: 127–36

37. Worsley KJ, Evans AC, Strother SC, Tyler JL (1991) A linear spatial correlation model with applications to positron emission tomography J Am Statist Assoc 86 (413): 55–67

38. Talbot JD, Marrett S, Evans AC, Meyer E, Bushnell MC, Duncan GH (1991) Multiple representations of pain in human cerebral cortex Science 251: 1355–8

39. Duncan GH, Bushnell MC, Talbot JD, Evans AC, Meyer E, Marrett S (1992) Pain-related activation of primary somatosensory cortex (SI) in man (response) Science 255: 2515–6

40. Meyer E, Ferguson S, Zatorre R, Alivisatos B, Marrett S, Evans AC, Hakim AM (1991) Attention modulates somatosensory CBF response to vibrotactile stimulation as measured by PET Ann Neurol 29(4): 440–3

41. Gjedde A, Reith J, Dyve S, Diksic M, Evans AC, Kuwabara H (1991) DOPA decarboxylase activity in the living human brain Proceedings of the National Academy of Science 88: 2721–5

42. Thompson CJ, Ranger N, Evans AC, Gjedde A (1991) Validation of simultaneous PET emission and transmission scans J Nucl Med 32: 154–60

43. Evans AC, Neelin P, Marrett S, Meyer E, Dai W, Collins DL (1991) Combined stereotactic mapping of MRI and PET studies of cognitive activation in human brain IEEE Trans Eng Med Biol 13(1): 224–6

44. Pelizzari CA, Evans AC, Neelin P, Chen C-T, Marrett S (1991) Comparison of two methods for 3D

45 45 registration of PET and MRI images IEEE Trans Eng Med Biol 13(1): 221–3

45. Evans AC, Dai W, Collins DL, Neelin P, Marrett S (1991) Warping of a computerized 3-D atlas to match brain image volumes for quantitative neuroanatomical and functional analysis Proceedings of the International Society of Optical Engineering (SPIE): Medical Imaging V 1445: 236–47

46. Zatorre RJ, Evans AC, Meyer E, Gjedde A (1992) Lateralization of phonetic and pitch discrimination in processing of speech Science 256: 846–9

47. Evans AC, Peters TM, Collins DL, Henri CJ, Marrett TS, Pike GB, Dai W (1992) 3-D Correlative imaging and sgementation of cerebral anatomy, function and vasculature Automedica, 14(1): 65– 80

48. Evans AC, Marrett S, Neelin P, Collins DL, Worsley K, Dai W, Milot S, Meyer E, Bub D (1992) Anatomical mapping of functional activation in stereotactic coordinate space NeuroImage 1(1): 43–63

49. Watson C, Andermann F, Gloor P, Jones-Gotman M, Peters T, Evans AC, Olivier A, Melanson D, Leroux G (1992) Anatomical basis of amygdaloid and hippocampal volume measurement by magnetic resonance imaging Neurology 42: 1743–50

50. Guttman M, Leger G, Cedarbaum JM, Reches A, Woodward W, Evans AC, Diksic M, Gjedde A (1992) 3-O-methyldopa administration does not alter fluorodopa transport into the brain Ann Neurol 31: 638–43

51. Leblanc R, Meyer E, Bub D, Zatorre R, Evans AC (1992) Language localization with activation PET scanning Neurosurgery: 31(2): 369–73

52. Worsley KJ, Evans AC, Marrett S, Neelin P (1992) Determining the number of statistically significant areas of activation in subtracted activation studies from PET J Cereb Blood Flow Metabol 12: 900–18

53. Duncan GH, Bushnell MC, Talbot JD, Evans AC, Meyer E, Marrett S (1992) Pain and activation in the thalamus Trends in Neuroscience 15(7): 252–3

54. Zatorre RJ, Jones-Gotman M, Evans AC, Meyer E (1992) Functional localization of human olfactory cortex with positron emission tomography Nature 360: 339–40

55. Petrides M, Alivisatos B, Evans AC, Meyer E (1993) Dissociation of human mid-dorsolateral frontal from posterior dorsolateral frontal cortex in memory processing Proc Nat Acad Sci 90: 873–7

56. Petrides M, Alivisatos B, Meyer E, Evans AC (1993) Functional activation of human frontal cortex during the performance of verbal working memory tasks Proc Nat Acad Sci 90: 878–82

57. Paus T, Petrides M, Evans AC, Meyer E (1993) Role of the human anterior cingulate cortex in the control of: oculomotor, manual and speech responses: a positron emission tomography study J Neurophysiol 70(2): 453–69

58. Kamber M, Collins DL, Shinghal R, Francis GS, Evans AC (1992) Model-based 3D segmentation of multiple sclerosis lesions in dual-echo MRI data Visualization in Biomedical Computing 1992: Proc SPIE 1808: 590–600

59. Collins DL, Dai W, Peters TM, Evans AC (1992) Model-based segmentation of individual brain structures from MRI data Visualization in Biomedical Computing 1992: Proc SPIE 1808: 10–23

46 46

60. Rousset OG, Ma Y, Kamber M, Evans AC (1993) 3D simulations of radiotracer uptake in deep nuclei of human brain Comput Medical Imag Graph 17 (4/5): 373–9

61. Neelin P, Crossman J, Hawkes D, Ma Y, Evans AC (1993) Evaluation of MRI/PET registration using simulated PET brain images Comput Medical Imag Graph 17 (4/5): 351–6

62. Ma Y, Kamber M, Evans AC (1993) Three-dimensional MRI-based simulation of PET images Comput Medical Imag Graph 17 (4/5): 365–71

63. Worsley KJ, Evans AC, Marrett S, Neelin P (1992) A three-dimensional statistical analysis for CBF activation studies in human brain (comment) J Cereb Blood Flow Metabol 13(6): 1040–2

64. Kuwabara H, Cumming P, Reith J, Leger G, Diksic M, Evans AC, Gjedde A (1993) Human striatal L-DOPA decarboxylase activity estimated in vivo using 6-[18F]fluoroDOPA and PET. Error analysis and application to normal subjects J Cereb Blood Flow Metabol 13: 43–56

65. Cendes F, Leproux F, Melancon D, Ethier R, Evans AC, Andermann F (1993) MRI of amygdala and hippocampus in temporal lobe epilepsy J Comput Assist Tomogr 17(2): 206–10

66. Cendes F, Andermann F, Gloor P, Evans AC, Jones-Gotman M, Watson C, Melancon D, Olivier A, Peters T, Lopes-Cendes I, Leroux G (1993) Volumetric measurements of amygdala and hippocampal formation in temporal lobe epilepsy Neurology 43: 719–25

67. Cendes F, Andermann F, Dubeau F, Gloor P, Evans AC, Jones-Gotman M, Olivier A, Andermann E, Robitaille Y, Melancon D (1993) Early childhood prolonged febrile convulsions, atrophy and sclerosis of mesial structures in temporal lobe epilepsy: An MRI volumetric study Neurology 43: 1083–7

68. Guttman M, Leger G, Reches A, Evans AC, Kuwabara H, Cedarbaum JM, Gjedde A (1993) Administration of the new COMT inhibitor OR-611 increases striatal uptake of fluorodopa Movement Disorders 8 (3): 298–304

69. Cendes F, Andermann F, GLoor P, Lopes-Cendes I, Andermann E, Melanson D, Jones-Gotman M, Carpenter S, Robitaille Y, Evans AC, Peters T (1993) Atrophy of mesial structures in patients with temporal lobe epilepsy: Cause or consequence of repeated seizures ? Ann Neurol 34(6): 795–801

70. Gjedde A, Leger G, Cumming P, Yasuhara Y, Evans AC, Guttman M, Kuwabara H (1993) Striatal L-DOPA decarboxylase activity in Parkinson’s Disease in vivo: Implications for the regulation of dopamine synthesis J Neurochem 61: 1538–41

71. Ptito A, Zatorre RJ, Petrides M, Frey S, Alivisatos B, Evans AC (1993) Localization and lateralization of stereoscopic procesing in the human brain Neuroreport 4(10): 1155–8

72. Evans AC, Collins DL, Mills SR, Brown ED, Kelly RL, Peters TM (1993) 3D statistical neuroanatomical models from 305 MRI volumes Proc IEEE-Nuclear Science Symposium and Medical Imaging Conference: 1813–7

73. Peters TM, Davey B, Comeau R, Henri CJ, Munger P, Charland P, Evans AC, Olivier A(1993) On- line stereoscopic image-guidance for neurosurgery Proc IEEE-Nuclear Science Symposium and Medical Imaging Conference: 1805–9

74. Coghill RC, Talbot J, Evans AC, Meyer E, Gjedde A, Duncan GH, Bushnell MC (1994) Distributed processing of pain and vibration by the human brain J Neurosci 14(7): 4095–108

47 47 75. Peters TM, Henri CJ, Munger P, Takahashi AM, Evans AC, Davey B, Olivier A (1994) Integration of stereoscopic DSA and 3-D MRI for image-guided neurosurgery Comput Med Imag Graph 18(4): 288–99

76. Collins DL, Neelin P, Peter TM, Evans AC (1994) Automatic 3D registration of MR volumetric data in standardized talairach space J Comput Assist Tomogr 18(2): 192–205

77. Friston KJ, Worsley KJ, Frackowiak RSJ, Mazziotta JC, Evans AC (1994) Assessing the significance of focal activations using their spatial extent Human Brain Mapping 1(3): 210–21

78. Klein D, Milner B, Zatorre R, Meyer E, Evans AC (1994) A PET study of bilingual processing: Left putaminal activation when speaking a second language: Evidence from PET Neuroreport 17(5): 2295–7

79. Cendes F, Andermann F, Gloor P, Gambardella A, Lopes-Cendes I, Watson C, Evans AC, Carpenter S, Olivier A (1994) Relationship between atrophy of the amygdala and ictal fear in temporal lobe epilepsy Brain 117: 739–46

80. Reith J, Benkelfat C, Sherwin A, Yasuhara Y, Kuwabara H, Andermann F, Bachneff S, Cumming P, Diksic M, Dyve S, Etienne P, Evans AC, Lal S, Shevell M, Savard G, Wong DF, Chouinard G, Gjedde A (1994) Elevated dopa decarboxylase activity in living brain of patients with psychosis Proc Nat Acad Sci 91: 11651–4

81. MacDonald D, Avis D, Evans AC (1994) Multiple surface identification and matching in magnetic resonance imaging Visualization in Biomedical Computing 1994: Proc SPIE 2359: 160–9

82. Collins DL, Peters TM, Evans AC (1994) An automated 3D non-linear deformation procedure for determination of gross morphometric variability in human brain Visualization in Biomedical Computing 1994: Proc SPIE 2359: 180–90

83. Zatorre R, Evans AC, Meyer E (1994) Neural mechanisms underlying melodic perception and memory for pitch J Neurosci 14(4): 1908–19

84. Francis GS, Evans AC, Arnold DL (1995) Neuroimaging in multiple sclerosis Neurological Clinics 13(1): 147–71

85. Collins DL, Evans AC, Holmes CJ, Peters TM (1995) Automatic 3D segmentation of neuroanatomical structures from MRI Proceedings of Annual Conference on Information Processing in Medical Imaging(IPMI): 139–52

86. Mazziotta JC, Toga AW, Evans AC, Fox P, Lancaster J (1995) A probabilistic atlas of the human brain: Theory and rationale for its development Neuroimage 2: 89–101

87. Benkelfat C, Bradwejn J, Meyer E, Ellenbogen M, Milot S, Gjedde A, Evans AC (1995) Functional neuroanatomy of CCK4-induced anxiety in normal healthy volunteers Am J Psych 152: 1180–4

88. Kamber M, Shinghal R, Collins DL, Francis GS, Evans AC (1995) Model-based 3D segmentation of multiple sclerosis lesions in MR brain images IEEE Trans Med Imag 14(3): 442–53

89. Mazziotta JC, Toga AW, Evans AC, Fox PT, Lancaster JL (1995) Digital brain atlases Trends in Neuroscience 18(5): 210–1

90. Paus T, Marrett S, Worsley KJ, Evans AC (1995) Extraretinal modulation of cerebral blood flow in the human visual cortex: Implications for saccadic suppression J Neurophysiol 74(5): 2179–83

48 48 91. Bonda E, Petrides M, Frey S, Evans AC (1995) Neural correlates of mental transformations of the body-in-space Proc Nat Acad Sci 92 (24): 11180-4

92. Owen AM, Doyon J, Petrides M, Evans AC (1995) Planning and spatial working memory: A positron emission tomography study in humans Europ J Neurosci 8: 353–64

93. Kuwabara H, Cumming P, Yasuhara Y, Léger G, Guttman M, Diksic M, Evans AC, Gjedde A (1995) Regional Striatal DOPA transport and decarboxylase activity in Parkinson’s Disease J Nucl Med 36(7): 1226–31

94. Zatorre RJ, Halpern AR, Perry DW, Meyer E, Evans AC (1995) Hearing in the mind’s ear: A PET investigation of musical imagery and perception J Cognit Neurosci 8 (1): 29–46

95. Petrides M, Alivisatos B, Evans AC (1995) Functional activation of human ventrolateral frontal cortex during mnemonic retrieval of verbal information Proc Nat Acad Sci 92: 5803–7

96. Lee JW, Reutens DC, Dubeau F, Evans AC, Andermann F (1995) Morphometry in temporal lobe epilepsy Mag Res Imag 13(8): 1073–80

97. Collins DL, Holmes CJ, Peters TM, Evans AC (1995) Automatic 3D segmentation of neuroanatomical structures from MRI Human Brain Mapping 3 (3): 190–208

98. Leblanc R, Meyer E, Zatorre R, Tampieri D, Evans AC (1995) Functional PET scanning in the preoperative assessment of cerebral arteriovenous malformations Stereotactic and Functional Neurosurgery 65(1-4): 60–4

99. Evans AC (1996) Spatial normalization of images: Commentary Human Brain Mapping 3(3): 254–6

100. Doyon J, Owen AM, Petrides M, Sziklas V, Evans AC (1996) Functional anatomy of visuomotor skill learning examined using positron emission tomography Europ J Neurosci 8: 637–48

101. Peters TM, Davey B, Munger P, Comeau R, Evans AC, Olivier A (1996) Three-dimensional multi-modal image-guidance for neurosurgery IEEE Transactions in Medical Imaging 15(2): 121–8

102. Worsley K, Marrett S, Neelin P, Vandal AC, Friston KJ, Evans AC (1996) A unified statistical approach for determining significant signals in images of cerebral activation Human Brain Mapping 4(1): 58–73

103. Worsley K, Marrett S, Neelin P, Evans AC (1996) Searching scale space for activation in a PET images Human Brain Mapping 4(1): 74–90

104. Bonda E, Petrides M, Ostry D, Evans AC (1996) Specific involvement of human parietal systems and the amygdala in the perception of biological motion J Neurosci 16(11): 3737–3744

105. Bonda E, Petrides M, Evans AC (1996) Neural systems for tactual memories J Neurophysiology 75(4): 1730–7

106. Evans AC (1996) Computational Neuroanatomy La Recherche (July - August): 42–45

107. Paus T, Tomaiuolo F, Otaky N, MacDonald D, Petrides M, Atlas J, Morris R, Evans AC (1996) Human cingulate and paracingulate sulci: Pattern, variability, asymmetry and probabilistic map Cerebral Cortex 6: 207–214

49 49 108. Klein D, Milner B, Zatorre R, Meyer E, Evans AC (1996) The neural substrates underlying word generation: A bilingual functional imaging study Proc Nat Acad Sci 92: 2899–2903

109. Owen AM, Evans AC, Petrides M (1996) Evidence for a two-stage model of spatial working memory processing within the lateral frontal cortex: a positron emission tomography study Cerebral Cortex 6(1): 31–38

110. Owen AM, Milner, Petrides M, Evans AC (1996) Memory for object features versus memory for object location: A positron emission tomography study of encoding and retrieval processes Proc Nat Acad Sci 93(17): 9212–17

111. Zatorre RJ, Evans AC, Meyer E, Gjedde A (1996) PET studies of phonetic processing of speech: Review, replication and re-analysis Cerebral Cortex 6(1): 21–30

112. Penhune VB, Zatorre RJ, MacDonald D, Evans AC (1996) Interhemispheric anatomical differences in human primary auditory cortex: Probabilistic mapping and volume measurement from MRI scans Cerebral Cortex 6(5): 661–672

113. Leblanc R, Meyer E, Zatorre R, Klein D, Evans AC (1996) Functional imaging of cerebral arteriovenous malformations with a comment on cortical reorganization Neurosurg Focus 1(3): 1– 6

114. Ohta S, Meyer E, Fujita H, Reutens DC, Evans AC, Gjedde A (1996) Cerebral 15O-water clearance in humans determined by PET: I. Theory and normal values J Cereb Blood Flow Metabol 16(5):765-80

115. Fujita H, Meyer E, Reutens DC, Kuwabara H, Evans AC, Gjedde A (1996) Cerebral 15O water clearance in humans determined by PET: II. Vascular response to vibrotactile stimulation J Cereb Blood Flow Metabol 17(1): 73–79

116. Paus T, Otaky N, Caramanos Z, MacDonald D, Zijdenbos AP, D’Avirro D, Gutmans D, Holmes CJ, Tomaiuolo F, Evans AC (1996) In-vivo morphometry of the intrasulcal gray matter in the human cingulate, paracingulate and superior rostral sulci: Hemispheric asymmetries, gender differences J Comparative Neurol 376: 664–673

117. Paus T, Perry DW, Zatorre RJ, Worsley KJ, Evans AC (1996) Modulation of cerebral blood flow in the human auditory cortex during speech: role of motor-to-sensory discharges Europ J Neurosci 8: 2236–2246

118. Paus T, Marrett S, Worsley K, Evans AC (1996) Imaging motor-to-sensory discharges in the human brain: An experimental tool for the assessment of functional connectivity Neuroimage 4: 78–86

119. Craig AD, Reiman E, Evans AC, Bushnell MC (1996) Functional imaging of an illusion of pain Nature 384 (6606): 258–60

120. Wong DF, Harris JC, Naidu S, Yokoi F, Marenco S, Dannals RF, Ravert HT, Yaster M, Evans AC, Rousset OG, Bryan RN, Gjedde A, Kuhar MJ, Breese GR (1996) Dopamine transporters are markedly reduced in Lesch-Nyhan Disease in vivo Proc Nat Acad Sci 93(11): 5539–43

121. Holmes CJ, MacDonald D, Sled JG, Toga AW, Evans AC Cortical peeling: CSF/grey matter/white matter boundaries visualized by nesting isosurfaces Proc. 4th International Conference on Visualization in Biomedical Computing, VBC ‘96: 99–104

122. Kwan R, Evans AC, Pike B (1996) An extensible MRI simulator for post-processing evaluation

50 50 Proc. 4th International Conference on Visualization in Biomedical Computing, VBC ‘96: 135–140

123. Collins DL, LeGoualher G, Venegopal R, Caramanos Z, Evans AC (1996) Cortical constraints for non-linear cortical registration Proc. 4th International Conference on Visualization in Biomedical Computing, VBC ‘96: 307–316

124. Zijdenbos AP, Evans AC, Riahi F, Sled J, Chui J, Kollokian V (1996) Automatic quantification of multiple sclerosis lesion volume using stereotaxic space Proc. 4th International Conference on Visualization in Biomedical Computing, VBC ‘96: 439–438

125. Watson C, Cendes F, Fuerst D, Dubeau F, Williamson B, Evans AC, Andermann F (1996) Specificity of volumetric magnetic resonance imaging in detecting hippocampal sclerosis Archives of Neurology 54(1): 67–73

126. Murtha S, Chertkow H, Beauregard M, Meyer, E, Hosein C, Evans AC (1996) Anticipation causes increased blood flow to the anterior cingulate cortex Human Brain Mapping 4: 103–113

127. Murase K, Kuwabara H, Yasuhara Y, Evans AC, Gjedde A (1996) Mapping of change in cerebral glucose utilization using 18F-fluoro deoxyglucose double injection and the constrained weighted-integration method IEEE Trans Med Imag 15(6): ? –?

128. Evans AC, Frank JA, Antel J, Miller DH (1997) The Role of MRI in Clinical Trials of Multiple Sclerosis: Comparison of Image Processing Techniques Annals of Neurology 41: 125–132

129. Poline J-B, Worsley KJ, Evans AC, Friston KJ (1997) Combining spatial extent and peak intensity to test for activations in functional imaging Neuroimage 5(2): 83–96

130. Paus T, Zatorre RJ, Hofle N, Caramanos Z, Gotman J, Petrides M, Evans AC (1997) Time- related changes in neural systems underlying attention and arousal during the performance of an auditory vigilance task J Cog Neurosci 9(3): 392–408

131. Johnsrude IS, Zatorre RJ, Milner BA, Evans AC (1997) Left-hemisphere specialization for the processing of acoustic transients Neuroreport 8: 1761–1765

132. Small DM, Jones-Gotman M, Zatorre RJ, Petrides M, Evans AC (1997) A role for the right anterior temporal lobe in taste quality recognition J Neuroscience 17(13): 5136–5142

133. Paus T, Jech R, Thompson CJ, Comeau R, Peters T, Evans AC (1997) Transcranial magnetic stimulation during positron emission tomography: A new method for studying connectivity of the human cortex J Neuroscience 17(9): 3178–3184

134. Hofle N, Paus T, Reutens D, Fiset P, Gotman J, Evans AC, B Jones (1997) Regional cerebral blood flow changes as a function of delta and spindle wave activity during slow wave sleep in humans J Neuroscience 17(12): 4800–4808

135. McMackin D, Dubeau F, Jones-Gotman M, Gotman J, Lukban A, Dean G, Evans AC, Tampieri T, Lisbona R (1997) Assessment of the functional effect of the intracarotid sodium amobarbital procedure using co-registered MRI/HMPAO-SPECT and SEEG Brain and Cognition 33(1): 50–70

136. Reutens DC, McHugh MD, Toussaint P.-J., Evans AC, Gjedde A, Meyer E, Stewart DJ L- arginine infusion increases basal but not activated cerebral blood flow in humans J Cereb Blood Flow Metab 17(3): 309–315

137. Kabani N, MacDonald D, Evans AC, Gopnik M (1997) Neuroanatomical correlates of familial

51 51 language impairment: A preliminary report J Neurolinguistics 10 (2/3): 203–214

138. Ashburner J, Neelin P, Collins DL, Evans AC, Friston KJ (1997) Incorporating prior knowledge into image registration Neuroimage 6: 344–352

139. Ma Y and Evans AC (1997) Analytical modeling of PET imaging with correlated functional and structural images IEEE Trans Nucl Sci 44(6): 2439–2444

140. Small DM, Jones-Gotman M, Zatorre RJ, Petrides M, Evans AC (1997) Flavour processing: More than the sum of its parts Neuroreport 8(18): 3913–3917

141. Klein D, Olivier A, Milner B, Zatorre R, Johnsrude I, Meyer E, Evans AC (1997) Obligatory role of the LIFG in synonym generation: evidence from PET and cortical stimulation Neuroreport 8(15): 3275–3279

142. Collins DL and Evans AC (1997) ANIMAL: Validation and applications of non-linear registration based segmentation Int J Pattern Recog Art Intel 11(8): 1271–1294

143. Cumming P, Deep P, Rousset OG, Evans AC, Gjedde A (1997) On the rate of decarboxylation of DOPA to dopamine in living mammalian brain Annals of New York Academy of Science 835: 274–308

144. Vowinckel E, Reutens D, Becher B, Verge G, Evans AC, Owens T, Antel J (1997) PK11195- binding to the peripheral benzodiazepine receptor as a marker of microglia activation in multiple sclerosis and experimental autoimmune encephalomyelitis J Neurosci Research 50(2): 345–353

145. Thompson PM, MacDonald D, Mega MS, Holmes CJ, Evans AC, Toga AW (1997) Detection and mapping of abnormal brain structure with a probabilistic atlas of cortical surfaces J Comp Assist Tomogr 21(4): 567–581

146. McMackin D, Jones-Gotman M, Dubeau F, Gotman J, Lukban A, Dean G, Evans AC, Lisbona R (1998) Regional carebral blood flow and language dominance: SPECT during intracarotid amobarbital testing Neurology 50(4): 943–950

147. Paus T, Jech R, Thompson CJ, Comeau R, Peters T, Evans AC (1998) Dose-dependent reduction of cortical excitability during rapid-rate transcranial magnetic stimulation of the human sensorimotor cortex: a positron emission tomography study J Neurophysiology 79: 1102-1107

148. Sled JG, Zijdenbos AP, Evans AC (1998) A non-parametric method for automatic correction of intensity non-uniformity in MRI data IEEE Trans Med Imag 17(1): 87–97

149. Rousset OG, Ma Y, Evans AC (1998) Correction for partial volume effects in positron emission tomography: Principle and validation J Nucl Med 39(5): 904–911

150. Riahi F, Zijdenbos AP, Narayanan S, Arnold D, Francis G, Antel J, Evans AC (1998) Improved correlation between EDSS and cerebral lesion load in relapsing-remitting multiple sclerosis: results of the application of new imaging methods Brain 121: 1305–1312

151. Beauregard M, Gold D, Evans AC, Chertkow H (1998) A role for the hippocampal formation in implicit memory: A 3-D PET study Neuroreport 9(8): 1867–1873

152. Filippi M, Horsfield M, Ader HJ, Barkhof F, Bruzzi P, Evans AC, Frank JA, Grossman RI, McFarland HF, Molyneux P, Paty DW, Simon J, Tofts PS, Wolinsky JS, Miller DH (1998) Guidelines for using quantitative measures of brain magnetic resonance imaging abnormalities in monitoring the treatment of multiple sclerosis Ann Neurol 43: 499–506

52 52

153. Collins DL, Zijdenbos AP, Kollokian V, Sled JG, Kabani NJ, Holmes CJ, Evans AC (1998) Design and construction of a realistic digital brain phantom IEEE Trans Med Imag 17(3): 463– 468

154. Owen AM, Doyon J, Dagher A, Sadikot A, Evans AC (1998) Abnormal basal ganglia outflow in Parkinson’s Disease identified with PET. Implications for higher cortical functions Brain 121(5): 949–965

155. Zatorre RJ, Perry DW, Beckett CA, CF Westbury, Evans AC (1998) Functional anatomy of musical processing in listeners with absolute pitch and relative pitch Proc Nat Acad Sci 95(6): 3172–3177

156. Holmes CJ, Hoge R, Collins DL, Woods R, Toga AW, Evans AC (1998) Enhancement of MR images using registration for signal averaging J Comp Assist Tomogr 22(2): 324–333

157. Worsley KJ, Poline J-B, Friston KJ, Evans AC (1998) Characterizing the response of PET and fMRI data using multivariate linear models Neuroimage 6(4): 305–319

158. Vafaee M, Meyer E, Marrett S, Evans AC, Gjedde A (1998) Increased oxygen consumption in human visual cortex: response to visual stimulation Acta Neurol Scand 98: 85–89

159. St-Jean P, Sadikot AF, Collins DL, Clonda D, Kasrai R, Evans AC, Peters TM (1998) Automated atlas integration and interactive three-dimensional visualization tools for planning and guidance in functional neurosurgery IEEE Transactions on Medical Imaging 17(5): 672–680

160. Lee JW, Andermann F, Dubeau F, Bernasconi A, MacDonald D, Evans AC, Reutens DC (1998) Morphometric analysis of the temporal lobe in temporal lobe epilepsy Epilepsia 39(7): 727–736

161. Dade LA, Jones-Gotman M, Zatorre RJ, Evans AC (1998) Human brain function during odor encoding and recognition. A PET study Ann NY Acad Sci 855: 572–574

162. Penhune VB, Zatorre RJ, Evans AC (1998) Cerebellar contributions to motor timimg: A PET study of auditory and visual rhythm reproduction J Cogn Neurosci 10(6): 752–765

163. Worsley KJ, Cao J, Paus T, Petrides M, Evans AC (1998) Applications of random field theory to functional connectivity Human Brain Mapping 6(5-6): 364–367

164. Zijdenbos AP, Forghani R, Evans AC (1998) Automatic quantification of MS lesions in 3D MRI brain data sets: Validation of INSECT Proc 1st. International Conference on Medical Computing and Computer-Assisted Intervention (MICCAI’98), LNCS 1496: 439–450

165. Collins DL, LeGoualher G, Evans AC (1998) Non-linear cerebral registration with sulcal constraints Proc 1st. International Conference on Medical Computing and Computer-Assisted Intervention (MICCAI’98), LNCS 1496: 974–984

166. LeGoualher G, Collins DL, Evans AC (1998) Automatic identification of cortical sulci using a 3D probabilistic atlas Proc 1st. International Conference on Medical Computing and Computer-Assisted Intervention (MICCAI’98), LNCS 1496: 509–518

167. Paus T, Zijdenbos AP, Worsley K, Collins DL, Blumenthal J, Giedd J, Rapoport J, Evans AC (1999) Structural maturation of neural pathway in children and adolescents Science 283: 1908– 1911

168. Vafaee M, Meyer E, Marrett S, Paus T, Evans AC, Gjedde A (1999) Frequency-dependent

53 53 changes in oxygen metabolism in cerebral metabolic rate of oxygen during activation of human visual cortex J Cereb Blood Flow Metabol 19(3): 272–277

169. Blood A, Zatorre R, Bermudez P, Evans AC (1999) Emotional responses to pleasant and unpleasant music correlate with activity in paralimbic brain regions Nature Neuroscience 2(4): 382–387

170. LeGoualher G, Procyk E, Collins DL, Venegopal R, Barillot C, Evans AC (1999) Automated extraction and variability analysis of sulcal neuroanatomy IEEE Trans Med Imag 18(3): 206–217

171. Rapoport JL, Giedd JN, Blumenthal J, Hamburger S, Jeffries N, Fernandez T, Nicolson R, Bedwell J, Lenane M, Zijdenbos AP, Paus T, Evans AC (1999) Progressive cortical change during adolescence in childhood-onset schizophrenia: A longitudinal magnetic resonance imaging study Arch Gen Psychiatry 56(7): 649–654

172. Westbury C, Zatorre RJ, Evans AC (1999) Quantifying variability in the planum temporale: A probability map Cerebral Cortex 9(4): 392–405

173. Fiset P, Paus T, Daloze T, Plourde G, Meuret P, Bonhomme V, Hofle N, Hajj-Ali N, Backman S, Evans AC (1999) Brain mechanisms of propofol-induced loss of consciousness in humans: A positron emission tomographic study J Neurosci 19(13): 5506–5513

174. Worsley KJ, Andermann M, Koulis T, MacDonald D, Evans AC (1999) Detecting changes in nonisotropic images Human Brain Mapping 8(2-3): 98–101

175. Murtha S, Chertkow H, Beauregard M, Evans AC (1999) The neural substrate of picture naming J Cognit Neurosci 11(4): 399-423

176. Belin P, Zatorre RJ, Hoge R, Evans AC, Pike B (1999) Event-related fMRI of the auditory cortex Neuroimage 10: 417–429

177. Schmahmann J, Doyon J, MacDonald D, Holmes CJ, Lavoie K, Hurwitz A, Evans AC, Petrides M (1999) Three-dimensional MRI atlas of the human cerebellum in proportional stereotaxic space Neuroimage 10(3): 233–260

178. Tomaiuolo F, MacDonald JD, Caramanos Z, Posner G, Chiavaras M, Evans AC, Petrides M (1999) Morphology, morphometry and probability mapping of the pars opercularis of the inferior frontal gyrus: an in vivo MRI analysis Eur J Neurosci 11: 3033–3046

179. Kwan RK-S, Evans AC, Pike GB (1999) MRI Simulation-Based Evaluation of Image Processing and Classification Methods IEEE Trans Med Imag 18(11): 1085–1097

180. O’Driscoll GA, Benkelfat C, Florencio PS, Wolff A-LVG, Joober R, Lal S, Evans AC (1999) Neural correlates of eye-tracking deficits in first-degree relatives of schizophrenic patients: A PET study Arch Gen Psych 56: 1127-1134

181. Giedd JN, Blumenthal J, Jeffries NO, Castellanos FX, Liu H, Zijdenbos AP, Paus T, Evans AC, Rapoport JL (1999) Brain development during childhood and adolescence: A longitudinal MRI study Nature Neuroscience 2(10): 861–863

182. Zatorre RJ, Mondor TA, Evans AC (1999) Auditory attention to space and frequency activates similar cerebral systems Neuroimage 10(5): 544–554

183. Perry DW, Zatorre RJ, Petrides M, Alivisatos B, Meyer E, Evans AC (1999) Localization of cerebral activity during simple singing Neuroreport 10(18): 3979–3984

54 54

184. Johnsrude IS, Owen AM, Crane J, Milner B, Evans AC (1999) A cognitive activation study of memory for spatial relationships Neuropsychologia 37(7): 829–841

185. Collins DL, Zijdenbos AP, Baare WFC, Evans AC (1999) ANIMAL+INSECT: Improved cortical structure segmentation Proceedings of Annual Conference on Information Processing in Medical Imaging(IPMI’99)(Springer, eds: A Kuba, M Samal, A Todd-Pokropek) LNCS 1613: 210– 223

186. O’Driscoll GA, Wolff A-LVG, Benkelfat C, Florencio PS, Lal S, Evans AC (2000) Functional neuroanatomy of smooth pursuit and predictive saccades Neuroreport 11(6): 1335–1340

187. Thompson PM, Giedd JN, Woods RP, MacDonald D, Evans AC, Toga AW (2000) Growth patterns in the developing human brain detected using continuum-mechanical tensor maps Nature 404(6774): 190–193

188. Pruessner JC, Li LM, Serles W, Pruessner M, Collins DL, Kabani N, Lupien S, Evans AC (2000) Volumetry of hippocampus and amygdala with high-resolution MRI and three-dimensional analysis software: Minimizing the discrepancies between laboratories Cerebral Cortex 10(4): 433–442

189. Dumoulin SO, Bittar R, Kabani N, Baker C, LeGoualher G, Pike GB, Evans AC (2000) A new anatomical landmark for reliable identification of human area V5/MT: A quantitative analysis of sulcal patterning Cerebral Cortex 10: 454–463

190. LeGoualher G, Argenti A.-M., Duyme M, Baare WF, Hulshoff Pol HE, Barillot C, Evans AC (2000) Satistical sulcal shape comparisons: Application to the detection of genetic encoding of the central sulcus shape Neuroimage 11: 564–574

191. MacDonald D, Kabani N, Avis D, Evans AC (2000) Automated 3D extraction of inner and outer surfaces of cerebral cortex from MRI Neuroimage 12(3): 340–56

192. Aston J, Gunn RN, Worsley KJ, Ma Y, Evans AC, Dagher A (2000) A statistical method for analysis of positron emission tomography ligand data Neuroimage 12(3): 245–56

193. Rousset OG, Deep P, Kuwabara H, Evans AC, Gjedde AH, Cumming P (2000) The effect of partial volume correction on estimates of the influx and cerebral metabolism of 6-18F-fluoro-L-dopa studied with PET in normal control and Parkinson’s Disease subjects Synapse 37(2): 81–89

194. Petitto L, Zatorre RJ, Gauna K, Nikelski EJ, Dostie D, Evans AC (2000) Speech-like cerebral activity in profoundly deaf people processing signed languages: Implications for the neural basis of human language Proc Nat Acad Sci 97(25): 13961 – 13966

195. Pruessner JC, Collins DL, Pruessner M, Evans AC (2001) Age and gender predict volume decline in the anterior and posterior hippocampus in early adulthood J Neuroscience 21(1): 194–200

196. Kabani N, LeGoualher G, MacDonald D, Evans AC (2001) Measurement of cortical thickness using an automated 3D algorithm: A validation study Neuroimage 13(2): 375–380

197. Castellanos FX, Giedd JN, Berquin PC, Walter JM, Sharp W, Tran T, Vaituzis AC, Blumenthal J, Nelson J, Bastain TM, Zijdenbos AP, Evans AC, Rapoport JL (2001) Quantitative brain magnetic resonance imaging in girls with attention-deficit/hyperactivity disorder Arch Gen Psychiatry 58: 289–295

198. Chiavaras MM, LeGoualher G, Evans AC, Petrides M (2001) Three-dimensional probabilistic atlas of the human orbitofrontal sulci in standardized stereotaxic space Neuroimage 13: 479–496

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199. Paus T, Collins DL, Evans AC, Leonard G, Pike B, Zijdenbos A (2001) Maturation of white matter in the human brain: A review of magnetic resonance studies Brain Res Bull 54(3): 255–266

200. Bonhomme V, Fiset P, Meuret P, Paus T, Plourde G, Backman S, Bushnell C, Evans AC (2001) Propofol anesthesia and cerebral blood flow changes elicited by vibrotactile stimulation: a positron emission tomograpy (PET) study J Neurophysiol 85(3): 1299–1308

201. Cohen J, Dale A, Evans AC, Mazziotta JC, Roland P (2001) Neuroinfomatics Sub-Committee of the Governing Council of the Organization for Human Brain Mapping (OHBM) Neuroimaging Databases Science 292: 1673–1676

202. Chung MK, Worsley KJ, Paus T, Cherif C, Collins DL, Giedd JN, Rapoport JL, Evans AC (2001) A unified statistical approach to deformation-based morphometry Neuroimage 14(3): 595– 606

203. O’Driscoll GA, Florencio PS, Gagnon D, Wolff A-LV, Benkelfat C, Mikula L, Lal S, Evans AC (2001) Amygdala-hippocampal volume and verbal memory in first-degree relatives of schizophrenic patients Psychiatry Research: Neuroimaging (107) : 75–85

204. Watkins KE, Paus T, Lerch JP, Zijdenbos AP, Collins DL, Neelin P, Worsley K , Evans AC (2001) Structural asymmetries in the human brain: a voxel-based statistical analysis of 142 MRI scans Cerebral Cortex 11(9): 868–77

205. Small DM, Zatorre RJ, Dagher A, Evans AC, Jones-Gotman M (2001) Changes in brain activity related to eating chocolate: From pleasure to aversion Brain 124(9): 1720–33

206. Dade LA, Zatorre RJ, Evans AC, Jones-Gotman M (2001) Working memory in another dimension: Functional imaging of human olfactory working memory Neuroimaging 14(3): 650–60

207. Collins DL, Montagnat J, Zijdenbos AP, Evans AC, Arnold DL (2001) Automated estimation of brain volume in Multiple Sclerosis with BICCR Proc. Information Processing in Medical Imaging (IPMI) (Springer, R Leahy and M Insana, eds.), LNCS 2082: 141–147

208. Hellier P, Barillot C, Corouge I, Gibaud B, LeGoualher G, Collins DL, Evans AC, Malandain G, Ayache N (2001) Retrospective evaluation of inter-subject brain registration Proc 4th International Conference on Medical Computing and Computer-Assisted Intervention (MICCAI’01), LNCS 2208: 258–265

209. Hulshoff Pol HE, Schnack HG, Mandl RC, van Haren NE, Koning H, Collins DL, Evans AC, Kahn RS (2001) Focal grey matter density changes in schizophrenia Arch Gen Psychiatry 58(12): 1118–1125

210. Mazziotta JC, Toga AW, Evans AC, Fox PT, Lancaster J, Zilles K, Woods R, Paus T, Simpson G, Pike B, Holmes CJ, Collins DL, Thompson P, MacDonald D, Iacoboni M, Schormann T, Amunts K, Palomero-Gallagher N, Geyer S, Parson L, Narr K, Kabani N, LeGoualher G, Boomsma D, Cannon T, Kawashima R, Mazoyer B: International Consortium for Brain Mapping (2001) Four-Dimensional probabilistic atlas of the human brain J Am Medical Informatics Assoc (JAMIA) 8(5): 401–30

211. Mazziotta JC, Toga AW, Evans AC, Fox PT, Lancaster J, Zilles K, Woods R, Paus T, Simpson G, Pike B, Holmes CJ, Collins DL, Thompson P, MacDonald D, Iacoboni M, Schormann T, Amunts K, Palomero-Gallagher N, Geyer S, Parson L, Narr K, Kabani N, LeGoualher G, Boomsma D, Cannon T, Kawashima R, Mazoyer B: International Consortium for Brain Mapping (2001) A Probabilistic Atlas and Reference System for the Human Brain Philosphical Transactions Royal

56 56 Society London B Biol Sci 356(1412): 1293–322

212. Cocosco CA and Evans AC (2001) Java Internet Viewer: A WWW tool for remote 3D medical image data visualization and comparison LNCS 2208: 1415–20

213. Worsley KJ, Liao CH, Aston J, Petre V, Duncan GH, Morales F, Evans AC (2002) A general statistical analysis for fMRI data Neuroimage 15(1): 1–15

214. Aston JAD, Cunningham V, Asselin MC, Hammers A, Evans AC, Gunn RN (2002) Positron emission tomography partial volume correction: Estimation, errors and algorithms J Cereb Blood Flow Metabol 22(8): 1019–34

215. Tisserand DJ, Pruessner JC, Sanz Arigita EJ, van Boxtel MP, Evans AC, Jolles J, Uylings HB (2002) Regional frontal cortical volumes decrease differentially in aging: an MRI study to compare volumetric approaches and voxel-based morphometry Neuroimage 2002 17(2): 657-69

216. Castellanos FX, Lee PP, Sharp W, Jeffries NO, Greenstein DK, Clasen LS, Blumenthal JD, James RS, Ebens CL, Walter JM, Zijdenbos AP, Evans AC, Giedd JN, Rapoport JL (2002) Developmental trajectories of brain volume abnormalities in children and adolescents with attention- deficit/hyperactivity disorder JAMA 288(14): 1740–8

217. Pruessner JC, Kohler S, Crane J, Pruessner M, Lord C, Byrne A, Kabani N, Collins DL, Evans AC (2002) Volumetry of temporopolar, perirhinal, entorhinal and parahippocampal cortex from high-resolution MR images: considering the variability of the collateral sulcus Cereb Cortex 12(12): 1342-53

218. Lafleur MF, Jackson PL, Malouin F, Richards CL, Evans AC, Doyon J (2002) Motor learning produces parallel dynamic functional changes during the execution and imagination of sequential foot movements Neuroimage 16(1): 142–57

219. Liao CH, Worsley KJ, Poline J-B, Duncan GH Evans AC (2002) Estimating the delay of the fMRI response Neuroimage 16(3): 593–606

220. Zijdenbos AP, Forghani R, Evans AC (2002) Automatic ‘pipeline’ analysis of 3D MRI data for clinical trials: Application to multiple sclerosis IEEE Trans Med Imag 21(10): 1280–91

221. Cocosco CA, Zijdenbos AP, Evans AC (2003) A fully automatic and robust MRI tissue classification method Med Imag Anal 7(4): 513–27

222. Chung MK, Worsley KJ, Robbins S, T Paus, Taylor J, Giedd JN, Rapoport JL, Evans AC (2003) Deformation-based surface morphometry appplied to gray matter deformation Neuroimage 18: 198- 213

223. Hellier P, Barillot C, Corouge I, Gibaud B, LeGoualher G, Collins DL, Evans AC, Malandain G, Ayache N, Christensen GE, Johnson HJ (2003) Retrospective evaluation of inter-subject brain registration IEEE Trans Med Imag 22(9): 1120–31

224. Charil A, Zijdenbos AP, Taylor J, Boelman C, Worsley K, Evans AC, Dagher A (2003) Statistical mapping analysis of lesion location and neurological disability in multiple sclerosis: application to 452 patient data sets Neuroimage 19(3): 532–44

225. Dumoulin SO, Hoge RD, Baker CL, Hess RF, Achtman RL, Evans AC (2003) Automatic segmentation of human visual retinotopic cortex Neuroimage 18(3): 576–87 226. Dumoulin SO, Baker CL, Hess RF, Evans AC (2003) Cortical specialization for processing first- and second-order motion Cerebral Cortex 13(12): 1375–85

57 57

227. Mangin J-F, Rivière D, Cachia A, Papadopoulos-Orfanos D, Collins DL, Evans AC, Régis J (2003) Object-based strategy for morphometry of the cerebral cortex Inf Proc Med Imag 18: 160– 71

228. Hulshoff Pol HE, Schnack HG, Mandl RCW, Cahn W, Collins DL, Evans AC, Kahn RS (2004) Focal white matter density changes in schizophrenia: reduced inter hemispheric asymmetry Neuroimage 21(1): 27–35

229. Gogtay N, Sporn A, Clasen L, Nugent T, Greenstein D, Nicolson R, Giedd J, Lenane M, Gochman P, Evans AC, Rapoport JL (2004) Comparison of progressive cortical gray matter loss in childhood-onset schizophrenia with that in childhood-onset atypical psychoses Archives of General Psychiatry 61(1): 17–22

230. Reilhac A, Lartizien C, Costes N, Sans S, Comtat C, Gunn RN, Evans AC (2004) A Monte Carlo-based simulator with high count-rate capabilities IEEE Trans Med Imag 51(1): 46–52

231. Taki Y, Goto R, Evans AC, Zijdenbos AP, Neelin P, Lerch J, Sato K, Ono S, Kinomura S, Nakagawa M, Sugiura M, Watanabe J, Fukuda H, Kawashima R (2004) Voxel-based morphometry of human brain with age and cerebrovascular risk factors Neurobiology of Aging 25: 455–63

232. Tohka J, Zijdenbos AP, Evans AC (2004) Fast and robust parameter estimation for statistical partial volume models in brain MRI Neuroimage 23(1): 84–97

233. Mangin JF, Poupon F, Duchesnay E, Riviere D, Cachia A, Collins DL, Evans AC, Regis J (2004) Brain morphometry using 3D moment invariants Med Imag Anal 8(3): 187–96

234. Mangin J-F, Rivière D, Cachia A, Duchesnay E, Cointepas Y, Papadopoulos-Orfanos D, Collins DL, Evans AC, Régis J (2004) Object-based strategy for morphometry of the cerebral cortex IEEE Trans Med Imag 23(8): 968–982

235. Tisserand DJ, Van Boxtel MP, Pruessner JC, Hofman P, Evans AC, Jolles J (2004) A voxel-based morphometric study to determine individual differences in gray matter density associated with age and cognitive change over time Cerebral Cortex 14(9): 966–973

236. Robbins S, Evans AC, Collins DL, Whitesides S (2004) Tuning and comparing spatial normalization methods Med Imag Anal 8: 311–323

237. Nagano-Saito A, Washimi Y, Arahata Y, Kachi T, Lerch JP, Evans AC, Dagher A, Ito K (2005) Cerebral atrophy and its relation to cognitive impairment in Parkinson disease Neurology 64: 224– 229

238. Lerch JP, Evans AC (2005) Cortical thickness analysis examined through power analysis and a population simulation Neuroimage 24(1):163-73

239. Lerch JP, Pruessner JC, Zijdenbos AP, Burger K, Hampel H, Teipel SJ, Evans AC (2005) Focal decline of cortical thickness in Alzheimer’s Disease identified by computational neuroanatomy Cerebral Cortex15(7):995-1001

240. de Bruin EA, Hulshoff Pol HE, Schnack HG, Janssen J, Bijl S, Evans AC, Kenemans JL, Kahn RS,Verbatena MN (2005) Focal brain matter differences associated with lifetime alcohol intake and visual attention in male but not in female non-alcohol-dependent drinkers Neuroimage 26: 536 – 545

241. Kovacevic N, Henderson JT, Chan E, Lifshitz N, Bishop J, Evans AC, Henkelman RM, Chen XJ

58 58 (2005) A three-dimensional MRI atlas of the mouse brain with estimates of the average and variability Cereb Cortex 15(5):639-45

242. Chung MK, Robbins S, Dalton KM, Davidson RJ, Alexander AL, Evans AC (2005) Cortical thickness analysis in autism via heat kernel smoothing NeuroImage 25(4):1256-65

243. Kim JS, Singh V, MacDonald D, Lee JM, Kim SI, Evans AC (2005) Automated 3D extraction and evaluation of the outer cortical surface using a Laplacian map and partial volume effect classification Neuroimage 27: 210—221

244. Worsley KJ, Chen J-I, Lerch J, Evans AC (2005) Comparing functional connectivity via thresholding correlations and singular value decomposition Philos Trans R Soc Lond B Biol Sci 360(1457):913-20

245. Hampel H, Burger K, Pruessner JC, Zinkowski R, DeBernardis J, Kerkman D, Leinsinger G, Evans AC, Davies P, Moeller HJ, Teipel SJ (2005) Correlation of cerebrospinal fluid levels of tau protein phosphorylated at threonine 231 with rates of hippocampal atrophy in Alzheimer disease Arch Neurol 62(5):770-3

246. Zijdenbos AP, Lerch JP , Bedell BJ, Evans AC (2005) Brain imaging in drug R&D Biomarkers 10(1): 58-68

247. Reilhac A, Batan G, Michel C, Grova C, Tohka J, Collins DL, Costes N, Evans AC (2005) 248. PET-SORTEO: Validation and Development of Database of Simulated PET Volumes 249. IEEE Trans Nucl Sci 52(5): 1321—1328

250. Evans AC & Brain Development Cooperative Group (www.brain-child.org) (2006) NIH MRI study of normal brain development Neuroimage 30(1):184--202

251. Lerch JP, Worsley K, Shaw WP, Greenstein DK, Lenroot RK, Giedd J, Evans AC (2006) Mapping Anatomical Correlations Across Cerebral Cortex (MACACC) using Cortical Thickness from MRI Neuroimage 31(3):993-1003

252. Evans AC (2006) Large-scale morphometric analysis of neuroanatomy and neuropathology Embryology and Neuroanatomy 210: 439-446

253. Shaw P, Greenstein, Lerch J, Clasen L, Lenroot R, Gogtay N, Evans A, Rapoport J, Giedd J (2006) Intellectual ability and cortical development in children and adolescents Nature 440(7084): 676—679

254. Shaw P, Greenstein D, Lerch J, Sharp W, Clasen L, Evans A, Giedd J, Castellanos FX, Rapoport J (2006) Longitudinal mapping of cortical thickness and clinical outcome in children and adolescents with attention deficit/hyperactivity disorder Arch Gen Psych 63:540-549

255. Hulshoff Pol HE, Schnack HG, Mandl RCW, Brans RGH, van Haren NEM, Baaré WFC, Oel CJ, Collins DL, Evans AC, Kahn RS (2006) Gray and white matter density changes in monozygotic andsame-sex dizygotic twins discordant for schizophrenia using voxel-based morphometry Neuroimage 31(2):482-428

256. Lee JK, Lee JM, Kim JS, Kim IY, Evans AC, Kim SI (2006) A novel quantitative cross- validation of different cortical surface reconstruction algorithms using MRI phantom Neuroimage 31(2):572-84

257. Aubert-Broche B, Collins DL, Evans AC (2006) A new improved version of the realistic digital brain phantom Neuroimage 32(1):138-45

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258. Hulshoff Pol HE, Schnack HG, Posthuma D, Mandl RCM, Baaré WM, van Oel1 C, van Haren N, Collins DL, EvansAC, Amunts K, Bürgel U, Zilles K, de Geus E, Boomsma DI, Kahn RS (2006) Genetic contributions to human brain morphology and intelligence J Neurosci 26(40):10235-42

259. Webster RI, Erdos C, Evans K, Majnemer A, Kehayia E, Thordardottir E, Evans AC, Shevell MI (2006) The Clinical Spectrum of Developmental Language Impairment in School-Age Children: Language, Cognitive and Motor Findings Pediatrics 118 (5): 1541-49

260. Teipel SJ, Pruessner JC, Faltraco F, Born C, Rocha-Unold M, Evans A, Moller HJ, Hampel H (2006) Comprehensive dissection of the medial temporal lobe in AD: measurement of hippocampus, amygdala, entorhinal, perirhinal and parahippocampal cortices using MRI J Neurol 253(6):794- 800

261. Reilhac A, Evans AC, Gimenez G, Costes N (2006) Creation and application of a simulated database of dynamic [18F] MPPF PET acquisitions incorporating inter-individual anatomical and biological variability IEEE Trans Med Imag 25(11):1431-9

262. Singh V, Chertkow H, Lerch JP, Evans AC, Dorr AE, Kabani NJ (2006) Spatial patterns of cortical thinning in mild cognitive impairment and Alzheimer’s disease Brain 129(11):2885-93

263. Aubert-Broche B, Griffin MP, Pike GB, Evans AC, Collins DL (2006) Twenty new digital brain phantoms for creation of validation image databases IEEE Trans Imag Med 25(11):1410-6

264. Giedd JN, Clasen LS, Wallace GL, Lenroot RK, Lerch JP, Wells EM, Blumenthal JD, Nelson JE, Tossell JW, Stayer C, Evans AC, Samango-Sprouse CA (2007) XXY (Klinefelter Syndrome): A Pediatric Quantitative Brain Magnetic Resonance Imaging Case-Control Study Pediatrics 119: 232- 40

265. Charil A, Dagher A, Lerch JP, Zijdenbos AP, Worsley KW, Evans AC (2007) Focal cortical atrophy in multiple sclerosis: Relation to lesion load and disability Neuroimage 34(2):509-17

266. Lupien SJ, Evans A, Lord C, Miles J, Pruessner M, Pike B, Pruessner J (2007) Hippocampal volume is as variable in young as in older adults : Implications for the notion of hippocampal atrophy in humans Neuroimage 34(2):479-85

267. Lyttelton OC, Boucher M, Robbins S, Evans AC (2007) An unbiased iterative group registration template for cortical surface analysis Neuroimage 34: 1535–44

268. Shaw P, Lerch J, Taylor K, Greenstein D, Clasen L, Evans AC, Rapoport J, Giedd JN (2007) Cortical morphology in children and adolescents with different apolipoprotein E gene polymorphisms: an observational study Lancet Neurol 6: 494--500

269. Chung MK, Dalton KM, Shen L, Evans AC, Davidson RJ (2007) Weighted Fourier series representation and its application to quantifying amount of gray matter IEEE Trans Med Imag 26(4):566-81

270. Almli CR, Rivkin,MJ, McKinstry RC & Brain Development Cooperative Group (2007) The NIH MRI Study of Normal Brain Development (Objective-2): Newborns, infants, toddlers, and preschoolers NeuroImage 35: 308–325

271. Waber DP, De Moor C, Forbes PW, Almli CR, Botteron KN, Leonard G, Milovan D, Paus T, Rumsey J & Brain Development Cooperative Group (2007) The NIH MRI study of normal brain development: Performance of a population based sample of healthy children aged 6 to 18 years on a neuropsychological battery J Int Neuropsych Soc 13: 1–18

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272. He Y, Chen ZJ, Evans AC (2007) Small-World anatomical networks in the human brain revealed by cortical thickness from MRI Cerebral Cortex 17(10):2407-19

273. Lancaster JL, Tordesillas-Gutiérrez D, Martinez M, Salinas F, Evans AC, Zilles K, Mazziotta JC, Fox PT (2007) Bias between MNI and Talairach coordinates analyzed using the ICBM-152 brain template Human Brain Mapping 28(11):1194-205

274. Pausova Z, Paus T , Abrahamowicz M, Almerigi J, Arbour N, Bernard M, Gaudet D, Hanzalek P, Hamet P, Evans AC, Kramer M, Laberge L, Leal S, Leonard G, Lerner J, Lerner RM, Mathieu J, Perron M, Pike B, Pitiot A, Richer L, Séguin JR, Syme C, Toro R, Tremblay RE, Veillette S, Watkins K (2007) Genes, Maternal smoking and the offspring brain and body during adolescence: Design of The Saguenay Youth Study Human Brain Mapping 28(6):502-518

275. Van Haren NEM, Hulshoff Pol HE, Schnack HG, Cahn W, Mandl RCW, Collins DL, Evans AC, Kahn RS (2007) Focal gray matter changes in schizophrenia across the course of the illness: A 5- year follow-up study Neuropsychopharmacology 32(10):2057-66

276. Eickhoff SB, Paus T, Caspers S, Grosbras M-H, Evans AC, Zilles K, Amunts K (2007) Assignment of functional activations to probabilistic cytoarchitectonic areas revisited Neuroimage 36(3): 511-21

277. Lenroot RK, Gogtay N, Greenstein DK, Wells EM, Wallace GL, Clasen LS, Blumenthal JD, Lerch J, Zijdenbos AP, Evans AC, Thompson PM, Giedd J.(2007) Sexual dimorphism of brain developmental trajectories during childhood and adolescence Neuroimage 36: 1065-73

278. Mzengeza S, Lakhrissi Y, Rosa-Neto P, Goertzen A, Aliaga A, Bedell B, Evans A (2007) Radiosynthesis of cis-4-[124I]iodo-l-proline as a prototype probe for imaging anterograde axoplasmic transport system using positron emission tomography (PET) J Label Compd Radiopharm 50: 636-7

279. Lartizien C, Kuntner C, Goertzen A, Evans AC, Reilhac A Validation of SORTEO monte carlo simulations for the geometries of the Concorde MicroPET R4 and Focus 220 systems (2007) Phys Med Biol 52(16): 4845-62

280. Shaw P, Gornick M, Lerch JP, Addington A, Seal J, Greenstein D, Sharp W, Evans AC, Giedd J, Castellanos FX, Rapoport JL (2007) Polymorphisms of the dopamine D4 receptor, clinical outcome and cortical structure in attention-deficit/ hyperactivity disorder Arch Gen Psych 4(8):921-31

281. Gogtay N, Greenstein D, Lenane M, Clasen L, Sharp W, Gochman P, Butler P, Evans A, Rapoport J (2007) Cortical brain development in nonpsychotic siblings of patients with childhood- onset schizophrenia Arch Gen Psych 64(7):772-80

282. Hyde KL , Lerch JP , Zatorre RJ , Griffiths TD, Evans AC, Peretz I (2007) Cortical Thickness In Congenital Amusia: When Less Is Better Than More J Neurosci 27(47):13028-32

283. Shaw P, Eckstrand K, Sharp W, Blumenthal J, Lerch J, Greenstein D, Clasen L, Evans A, Giedd J, Rapoport JL (2007) Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation Proc Nat Acad Sci 104(49): 19649-54

284. Zhang J, Evans AC, Hermoye L, Lee S-K, Wakana S, Zhang W, Donohue P, Miller MI, Huang H, Wang X, van Zijl PCM, Mori S (2007) Evidence of slow maturation of the superior longitudinal fasciculus in early childhood by diffusion tensor imaging NeuroImage 38(2): 239-247

285. Lerch JP, Pruessner J, Zijdenbos AP, Collins DL, Teipel SJ, Hampel H, Evans AC (2008) 61 61 Automated cortical thickness measurements from MRI can accurately separate Alzheimer's patients from normal elderly controls Neurobiology of Aging 29: 23--30

286. Im K, Lee J-M, Lyttelton O, Kim, SH, Evans AC, Kim SI (2008) Brain size and cortical structure in the adult human brain Cerebral Cortex 18(9):2181-91

287. Belmonte MK, Mazziotta JC, Minshew NJ, Evans AC, Courchesne E, Dager SR, Bookheimer SY, Aylward EH, Amaral DG, Cantor RM, Chugani DC, Dale AM, Davatzikos C, Gerig G, Herbert MR, Lainhart JE, Murphy DG, Piven J, Reiss AL, Schultz RT, Zeffiro TA, Levi-Pearl S, Lajonchere C, Colamarino SA (2008) Offering to Share: How to put heads together in autism neuroimaging J Autism Dev Disord 38(1):2-13

288. Chen ZJ, He Y, Rosa-Neto P, Germann J, Evans AC (2008) Revealing modular architecture of human brain structural networks by using cortical thicknrss from MRI Cerebral Cortex 18(10):2374-81

289. He Y, Chen ZJ, Evans AC (2008) Structural insights into aberrant topological patterns of large- scale cortical networks in Alzheimer's Disease J Neurosci 28(18):4756-66

290. Shaw P, Kabani N, Lerch JP, Eckstrand K, Lenroot R, Gogtay N, Greenstein D, L. Clasen, Evans AC, Rapoport JL, Giedd JN, Wise SP (2008) Neurodevelopmental trajectories of the human cerebral cortex J Neurosci 28(14): 3586-94

291. Mori S, Oishi K, Jiang H, Jiang L, Li X, Akhter K, Hua K, Faria A, Mahmood A, Woods R, Toga AW, Pike GB, Rosa Neto P, Evans AC, Zhang J, Huang H, Miller M, van Zijl P, Mazziotta J (2008) Stereotaxic white matter atlas based on diffusion tensor imaging in an ICBM template Neuroimage 40(2):570-82

292. Lerch JP, Carroll JB, Dorr A, Spring S, Evans AC, Hayden MR, Sled JG, Henkelman RM.(2008) Cortical thickness measured from MRI in the YAC128 mouse model of Huntington's disease Neuroimage 41(2):243-51

293. Assadian S, Aliaga A, Del Maestro RF, Evans AC, Bedell BJ.(2008) FDG-PET imaging for the evaluation of antiglioma agents in a rat model Neuro Oncol Neuro Oncol 10(3):292-9

294. Bernhardt BC, Worsley KJ, Besson P, Concha L, Lerch JP, Evans AC, Bernasconi N (2008) Mapping limbic network organization in temporal lobe epilepsy using morphometric correlations: Insights on the relation between mesiotemporal connectivity and cortical atrophy Neuroimage 42(2):515-24

295. Lau JC, Lerch JP, Sled JG, Henkelman RM, Evans AC, Bedell BJ (2008) Longitudinal neuroanatomical changes determined by deformation-based morphometry in a mouse model of Alzheimer's disease Neuroimage 42(1):19-27

296. Evans AC, Lee JM, Kim SI, Fukuda H, Kawashima R, He Y, Jiang T, Kim JS, Chen Z, Im K, Lyttelton O, Lerch J, Singh V, Sato K, Taki Y, Goto R, Kinomura S, Mok K , Lee JK, Yoon U (2008) Human cortical anatomical networks assessed by structural MRI Brain Imaging and Behavior 2:289--299

297. Peper JS, Brouwer RM, Schnack HG, van Baal GCM, van Leeuwen M, van den Berg SM, Delemarre-Van de Waal HA, Janke AL, Collins DL, Evans AC, Boomsma DI, Kahn RS, Hulshoff Pol HE (2008) Cerebral white matter in early puberty is associated with luteinizing hormone concentrations Psychoneuroendocrinology 33(7): 909-15

298. Oishi K, Zilles K, Amunts K, Faria A, Jiang H, Li X, Akhter K, Hua K, Woods R, Toga AW, Pike

62 62 GB, Rosa Neto P, Evans AC, Zhang J, Huang H, Miller M, van Zijl P, Mazziotta J, Mori S (2008) Human brain white matter atlas: Identification and assignment of common anatomical structures in superficial white matter Neuroimage 43(3):447-57

299. Webster RI, Erdos C, Evans K, Majnemer A, Saigal G, Kehayia E, Thordardottir E, Evans A, Shevell MI (2008) Neurological and magnetic resonance imaging findings in children with developmental language impairment J Child Neurol 23(8): 870—7

300. Richards BA, Chertkow H, Singh V, Robillard A, Massoud F, Evans AC, Kabani NJ (2009) Patterns of cortical thinning in Alzheimer’s disease and fronto-temporal dementia Neurobiol Aging 30(10):1626-36

301. Karama S, Ad-Dab’bagh Y, Haier RJ , Deary IJ, Lyttelton OC, Lepage C, Evans AC & Brain Development Cooperative Group (2009) Positive association between cognitive ability and cortical thickness in a representative US sample of healthy 6 to 18 year-olds Intelligence 37(2):145- 55

302. Schmitt JE, Lenroot R, Ordaz SE, Wallace GL, Lerch JP, Evans AC, Prom EC, Kendler KS, Neale MC, Giedd JN (2009) Variance decomposition of MRI-based covariance maps using genetically-informative samples and structural equation modeling Neuroimage 47(1):56-64

303. Chakravarty MM, Rosa-Neto P, Broadbent S, Evans AC, Collins DL (2009) Robust S1, S2, and thalamic activations in individual subjects with vibrotactile stimulation at 1.5 and 3.0 T Human Brain Mapping 30(4):1328-37

304. Boucher M, Whiteside S, Evans AC (2009) Depth potential functions for shape pattern representation, registration and analysis Med Image Anal 13(2):203-14

305. Shaw P, Sharp W, Morrison M, Eckstrand K, Greenstein D, Clasen L, Evans AC, Rapoport JL (2009) Psychostimulant treatment and the developing cortex in Attention-Deficit/Hyperactivity Disorder Am J Psychiatry 166(1):58-63

306. Lenroot RK; Schmitt ES; Ordaz SE; Wallace G, Neale MC, Lerch JP; Kendler KS, Evans AC, Giedd JN (2009) Differences in genetic and environmental influences on the human cerebral cortex associated with developmental changes during childhood and adolescence Human Brain Mapping 30(1):163-74

307. Gong G, He Y, Concha L, Lebel C, Gross DW, Evans AC, Beaulieu C (2009) Mapping anatomical connectivity patterns of human cerebral cortex using in-vivo diffusion tensor imaging tractography Neuroimage 19(3):524-36

308. Leppert IR, Almli CR, McKinstry RC, Mulkern RV, Pierpaoli C, Rivkin MJ, Pike GB & Brain Development Cooperative Group (2009) T2 relaxometry of normal pediatric brain development J Mag Res Imag 29(2): 258-67

309. Hyde KL, Lerch J, Norton A, Forgeard M, Winner E, Evans AC, Schlaug G (2009) Musical training shapes structural brain development J Neurosci 29(10):3019-25

310. Bermudez P, Lerch JP, Evans AC, Zatorre RJ (2009) Neuro-anatomical correlates of musicianship as revealed cortical thickness and voxel-based morphometry Cerebral Cortex 19(7):1583-96

311. Yoon U, Fonov V, Perusse D, Evans AC & Brain Development Cooperative Group (2009) The effect of template choice on morphometric analysis of pediatric brain data Neuroimage 45(3):769- 77

63 63

312. Bernhardt BC, Rozen DA, Worsley KJ, Evans AC, Bernasconi N, Bernasconi A (2009) Thalamo–cortical network pathology in idiopathic generalized epilepsy: Insights from MRI-based morphometric correlation analysis Neuroimage 46: 373-81

313. Oishi K, Faria A, Jiang H, Li X, Akhter K, Zhang J, Hsu JT, Miller MI, van Zijl PCM, Albert M, Lyketsos CG , Woods R, Toga AW, Pike GB, Rosa-Neto P, Evans A, Mazziotta J, Mori S (2009) Atlas-based whole brain white matter analysis using large deformation diffeomorphic metric mapping: Application to normal elderly and Alzheimer's disease participants Neuroimage 46(2): 486-499

314. Lyttelton OC, Karama S, Ad-Dab’bagh Y, Carbonell F, Worsley K, Evans AC (2009) Positional and surface area asymmetry of the human cerebral cortex explored through automated surface-based analysis Neuroimage 46(4):895-903

315. Bellec P, Perlbarg V, Evans AC (2009) Bootstrap generation and evaluation of an fMRI simulation database Magn Res Imaging 27(10):1382-96

316. Uludağ K, Evans AC, Della-Maggiore V, Kochen S, Amaro E, Sierra O, Valdés-Hernandez P, Medina V, Valdés-Sosa P (2009) Latin American Brain Mapping Network (LABMAN) Neuroimage 47(1):312-3

317. Peper JS , Schnack HG , Brouwer RM , Van Baal GCM , Pjetri E , Székely E , van Leeuwen M, van den Berg SM , Collins DL , Evans AC , Boomsma DI, Kahn RS , Hulshoff Pol HE (2009) Heritability of regional and global brain structure at the onset of puberty: A magnetic resonance imaging study in 9-year-old twin pairs Human Brain Mapping 30(7): 2184-96

318. He Y, Dagher A, Chen Z, Charil A, Lerch J, Zijdenbos A, Worsley K, Evans AC (2009) Impaired small-world efficiency in structural cortical networks in multiple sclerosis associated with white matter lesion load Brain 132(12): 3366—79

319. Bernhardt BC, Worsley KJ, Kim H, Evans AC, Bernasconi A, Bernasconi N (2009) Longitudinal and cross-sectional analysis of atrophy in pharmacoresistant temporal lobe epilepsy Neurology 72(20):1747-54

320. Taylor J, Evans A, Friston K (2009) A tribute to Keith Worsley – 1951-2009 Neuroimage 46(4):891-4

321. Shaw P, Wallace GL, Addington A, Evans A, Rapoport J, Giedd JN (2009) Effects of the Val158Met catechol-O-methyltransferase polymorphism on cortical structure in children and adolescents Mol Psychiatry 14(4): 348—349

322. He Y, Wang J, Wang L, Chen ZJ, Yan C, Yang H, Tang H, Zhu C, Gong Q, Zang Y, Evans AC (2009) Uncovering intrinsic modular organization of spontaneous brain activity in humans PLoS ONE 4(4):e5226

323. Costes N, Dagher A, Larcher K, Evans AC, Collins DL, Reilhac A (2009) A Motion correction of multi-frame PET data in neuroreceptor mapping: simulation based validation Neuroimage 47(4):1496-505

324. He Y, Chen Z, Gong G, Evans AC (2009) Neuronal Networks in Alzheimer’s disease Neuroscientist 15(4):333-50

325. Gong G, Rosa-Neto P, Carbonell F, Chen ZJ, He Y, Evans AC (2009) Age- and gender-related differences in the cortical anatomical network J Neurosci 29(50): 15684--93

64 64

326. Koo J, Evans AC, Gross W (2009) Accelerating a medical 3D brain MRI analysis algorithm using a high-performance reconfigurable computer IEEE Trans Imag Proc 18(12):2735--46

327. Hyde KL, Lerch JP, Norton A., Forgeard M., Winner,E., Evans AC, Schlaug G (2009) The effects of musical training on structural brain development: a longitudinal study Ann NY Acad Sci 1169:182-6

328. Hyde KL, Samson F, Evans AC, Mottron L (2009) Neuroanatomical differences in brain areas implicated in perceptual and other core features of autism revealed by cortical thickness analysis and voxel-based morphometry Human Brain Mapping 31(4): 556-566

329. Boucher M, Evans A, Siddiqi K (2009) Oriented morphometry of folds on surfaces Inf Process Med Imaging (IPMI) 21: 614-625

330. Massarweh G, Kovacevic M, Rosa-Neto P, Evans AC, Diksic M, Schirrmacher R (2009) Time efficient and convenient synthesis of [18F]altanserin for human PET imaging by a new work-up procedure Appl Radiat Isot. 67(11):2040-3

331. Fahim C, Meguid N, Evans AC (2009) Anterior to posterior limb of the internal capsule morphology in fragile X syndrome Dev Med Child Neurol 51(10): 839-40

332. Bakalar JL, Greenstein DK, Clasen L, Tossell JW, Miller R, Evans AC, Mattai AA, Rapoport JL, Gogtay N (2009) General absence of abnormal cortical asymmetry in childhood-onset schizophrenia: A longitudinal study Schizophr Res115(1):12-6

333. Fahim C, Yoon U, Sandor P, Frey K, Evans AC (2009) Thinning of the motor–cingulate–insular cortices in siblings concordant for Tourette Syndrome Brain Topography 22(3):176-84

334. Julkunen V, Niskanen E, Muehlboeck S, Pihlajamäki M, Könönen M, Hallikainen M, Kivipelto M, Tervo S, Vanninen R, Evans A, Soininen H & AddNeuroMed Consortium (2009) Cortical thickness analysis to detect progressive mild cognitive impairment — a reference to Alzheimer's disease Dement Geriatr Cogn Disord. 28(5):404-12

335. Simmons A, Westman E, Muehlboeck S, Mecocci P, Vellas B, Tsolaki M, Kłoszewska I, Wahlund L-O, Soininen H, Lovestone S, Evans AC, Spenger C & AddNeuroMed Consortium (2009) MRI measures of Alzheimer's disease and the AddNeuroMed study Ann N Y Acad Sci 1180:47-55

336. Bellec P, Rosa-Neto P, Lyttelton O, Benali H, Evans AC (2010) Multi-level bootstrap analysis of stable clusters in resting state fMRI Neuroimage 51(3):1126-39

337. Im K, Jo HJ, Mangin J-F, Evans AC, Kim SI, Lee J-M (2010) Spatial distribution of deep sulcal landmarks and its hemispheric asymmetry on the cortical surface Cereb Cortex 20(3):602-11

338. Yoon U, Fahim C, Perusse D, Evans AC (2010) Lateralized genetic and environmental influences on human brain morphology of 8-year old pediatric twins Neuroimage 53(3):1117-25

339. Spring S, Lerch JP, Wetzel MK, Evans AC, Henkelman RM (2010) Cerebral asymmetries in 12- week old C57Bl/6J mice measured by magneticresonance imaging Neuroimage 50(2):409-15

340. He Y and Evans AC (2010) Graph theoretical modeling of brain connectivity. Curr Opin Neurol (4):341-50

341. Lange N, Froimowitz MP, Bigler ED, Lainhart JE & Brain Development Cooperative Group

65 65 (2010) Associations between IQ, total and regional brain volumes, and demography in a large normative sample of healthy children and adolescents Dev Neuropsychol 35(3):296-317

342. Meguid N, Fahim C, Yoon U, Nashaat NH, Ibrahim AS, Mancini-Marie A, Brandner C, Evans AC (2010) Brain morphology in autism and fragile x syndrome correlates with social IQ: First report from the Canadian-Swiss-Egyptian Neurodevelopmental Study (CSENS) J Child Neurol 5(5):599-608

343. Fahim C, Yoon U, Das S, Lyttelton O, Chen J, Arnaoutelis R, Rouleau G, Sandor P, Frey K, Catherine Brandner, Evans AC (2010) Somatosensory–motor bodily representation cortical thinning in Tourette: Effects of tic severity, age and gender Cortex 46(6):750-60

344. Brans RG, Kahn RS, Schnack HG. van Baal GCM, Posthuma D, van Haren NEM, Lepage C, Lerch JP, Collins DL, Evans AC, Boomsma DI , Hulshoff Pol HE (2010) Brain plasticity and intellectual ability are influenced by shared genes J Neurosci 30(16):5519-24

345. Schnack HG, van Haren NE, Brouwer RM, van Baal GC, Picchioni M, Weisbrod M, Sauer H, Cannon TD, Huttunen M, Lepage C, Collins DL, Evans A, Murray RM, Kahn RS, Hulshoff Pol HE (2010) Mapping reliability in multicenter MRI: voxel-based morphometry and cortical thickness Hum Brain Mapp (12):1967-82

346. Reid AT, van Norden AGW, de Laat KF, van Oudheusden LJB, Zwiers MP, Evans AC, de Leeuw F-E, Kötter R (2010) Patterns of cortical degeneration in an elderly cohort with cerebral small vessel disease Human Brain Mapping 31(12):1983-92

347. Lyu I, Seong J-K, Shin SY, Im K, Roh JH, Kim M-J, Kim GH, Kim JH, Evans AC, Na DL, Lee J-M (2010) Spectral-based automatic labeling and refining of human cortical sulcal curves using expert-provided examples Neuroimage 52(1):142-57

348. Thambisetty M, Simmons A, Velayudhan L, Hye A, Campbell J, Zhang Y, Wahlund L-O, Kinsey A, Guentert A, Proitsi P, Powell J, Causevic M, Killick R, Lynham S, Broadstock M, Tunnard C, Leung R, Foy C, O’Brien D, Breen G, Furney S, Ward M, Kloszewska I, Mecozzi P, Soininen H, Tsolaki M, Vellas B, Williams J , Murphy D, Parkins S, Resnick S, Ferucci L, Wong D, Zhou Y, Muehlboeck S, Evans A, Francis P, Spenger C, Lovestone S and other participants & AddNeuroMed Consortium (2010) Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease.Arch Gen Psychiatry. 2010 Jul;67(7):739-48

349. Liu Y, Paajanen T, Westman E, Zhang Y, Wahlund LO, Simmons A, Tunnard C, Sobow T, Proitsi P, Powell J, Mecocci P, Tsolaki M, Vellas B, Muehlboeck S, Evans A, Spenger C, Lovestone S, Soininen H (2010) APOE ε2 allele is associated with larger regional cortical thicknesses and volumes Dement Geriatr Cogn Disord 30(3): 229-237

350. Westman E, Simmons A, Zhang Y, Muehlboeck JS, Tunnard C, Y, Collins L, Evans A, Mecocci P, Vellas B, Tsolaki M, Kłoszewska I, Soininen H, Lovestone S, Spenger C, Wahlund LO; & AddNeuroMed Consortium (2011) Multivariate analysis of MRI data for Alzheimer's disease, mild cognitive impairment and healthy controls. Neuroimage 54(2): 1178-87

351. Liu Y, Paajanen T, Westman E, Wahlund LO, Simmons A, Tunnard C, Sobow T, Proitsi P, Powell J, Mecocci P, Tsolaki M, Vellas B, Muehlboeck S, Evans A, Spenger C, Lovestone S, Soininen H & AddNeuroMed Consortium (2010) Effect of APOE ε4 allele on cortical thicknesses and volumes: the AddNeuroMed study. J Alzheimers Dis 21(3):947-66

352. Liu Y, Paajanen T, Zhang Y, Westman E, Wahlund LO, Simmons A, Tunnard C, Sobow T, Mecocci P, Tsolaki M, Vellas B, Muehlboeck S, Evans A, Spenger C, Lovestone S, Soininen H & AddNeuroMed Consortium (2010) Analysis of regional MRI volume and thicknesses as predictors of

66 66 conversion from mild cognitive impairment to Alzheimer's disease Neurobiol Aging 31(8):1375-85

353. Boucher M, Evans A, Siddiqi K (2011) Anisotropic diffusion of tensor fields for fold shape analysis on surfaces Inf Process Med Imaging 22: 271-82

354. Buchy L, Ad-Dab'bagh Y, Malla A, Lepage C, Bodnar M, Joober R, Sergerie K, Evans A, Lepage M (2011) Cortical thickness is associated with poor insight in first-episode psychosis J Psychiatr Res 45(6): 781-7

355. Fan L, Tang Y, Sun B, Gong G, Chen ZJ, Lin X, Yu T, Li Z, Evans AC, Liu S (2010) Sexual dimorphism and asymmetry in human cerebellum: An MRI-based morphometric study Brain Research 1353:60-73

356. Bedell BJ, Bohle S, Chua Z, Czerniewski A, Evans AC, Mzengeza S (2010) Novel β- galactosidase-specific O2-glycosylated diazeniumdiolate probes Can J Chem 88(9): 969-80

357. Zuo X-N, Kelly C, Di Martino A, Mennes M, Margulies DS, Bangaru S, Grzadzinski R, Evans AC, Zang Y-F, Castellanos FX, Milham MP (2010) Growing together and growing apart: Regional and sex differences in the lifespan developmental trajectories of functional homotopy J Neurosci 30(45):15034-43

358. Rais M, van Haren NE, Cahn W, Schnack HG, Lepage C, Collins L, Evans AC, Hulshoff Pol HE, Kahn RS (2010) Cannabis use and progressive cortical thickness loss in areas rich in CB1 receptors during the first five years of schizophrenia.Eur Neuropsychopharmacol 20(12):855-65

359. Julkunen V, Niskanen E, Koikkalainen J, Herukka SK, Pihlajamäki M, Hallikainen M, Kivipelto M, Muehlboeck S, Evans AC, Vanninen R, Soininen H (2010) Differences in cortical thickness in healthy controls, subjects with mild cognitive impairment, and Alzheimer's disease patients: a longitudinal study J Alzheimers Dis 21(4): 1141-51

360. Shaw P, Gilliam M, Liverpool M, Weddle C, Malek M, Sharp W, Greenstein D, Evans AC, Rapoport J, Giedd J (2011) Cortical development in typically developing children with symptoms of hyperactivity and impulsivity: support for a dimensional view of Attention-Deficit Hyperactivity Disorder Am J Psychiatry 168(2): 143-51

361. Fonov V, Evans AC, Botteron K, Almli R, McKinstry R, Collins DL & Brain Development Cooperative Group (2011) Unbiased average age-appropriate atlas for pediatric studies Neuroimage 54(1):313-27

362. Gong G, He Y, Evans AC (2011) Brain Connectivity: Gender Makes a Difference Neuroscientist 17(5): 575-91

363. Karama S, Colom R, Johnson W, Deary IJ, Haier R, Waber DP, Lepage C, Ganjavi H, Jung R, Evans AC & Brain Development Cooperative Goup (2011) Cortical thickness correlates of specific cognitive performance accounted for by the General Factor of Intelligence in healthy children aged 6 to 18 Neuroimage 55(4):1443-53

364. Jubault T, Gagnon J-F, Karama S, Ptito A, Lafontaine A-L, Evans AC, Monchi O (2011) Patterns of cortical thickness and surface area in early Parkinson's Disease Neuroimage 55(2): 462—7

365. Chen ZJ, He Y, Rosa-Neto P, Gong G, Evans AC (2011) Age-related alterations in the modular organization of structural cortical network by using cortical thickness from MRI Neuroimage 56: 235-42

67 67 366. Yan C, Gong G, Wang J, Wang D, Liu D, Zhu C, Chen ZJ, Evans A, Zang Y, He Y (2011) Sex- and brain size-related small-world structural cortical networks in young adults: A DTI tractography study Cerebral Cortex 21(2):449-58

367. Yoon U, Perusse D, Lee J-M, Evans AC (2011) Genetic and environmental influences on structural variability of the brain in pediatric twin: Deformation based morphometry Neurosci Lett 493 (1-2):8-13

368. Bernhardt BC, Chen ZJ, He Y, Evans AC, Bernasconi N (2011) Graph-theoretical analysis reveals disrupted small-world organization of cortical thickness correlation networks in temporal lobe epilepsy. Cerebral Cortex 21(9): 2147-57

369. Ducharme S, Hudziak JJ, Botteron KN, Ganjavi H, Lepage C, Collins DL, Albaugh MD, Evans AC, Karama S & Brain Development Cooperative Group (2011) Right anterior cingulate cortical thickness and bilateral striatal volume correlate with CBCL Aggressive Behaviour scores in healthy children Biological Psychiatry 70(3): 283-90

370. Ganjavi H, Lewis JD, Bellec P, MacDonald PA, Waber D, Evans AC, Karama S & Brain Development Cooperative Group (2011) Negative associations between corpus callosum midsagittal area and IQ in a representative sample of healthy children and adolescents PLoS ONE 6(5): e19698

371. Zhou D, Lebel C, Lepage C, Rasmussen C, Evans AC, Wyper K, Pei J, Andrew G, Massey A, Massey D (2011) Developmental Cortical Thinning in Fetal Alcohol Spectrum Disorders Neuroimage 58(1):16-25

372. Frisoni GB, Redolfi A, D, Rousseau M-E, Toga A, Evans AC (2011) Virtual imaging laboratories for marker discovery in neurodegenerative diseases Nature Reviews Neurology 7(8):429-38

373. Portales-Casamar E, Evans AC, Wasserman W, Pavlidis P (2011) The NeuroDevNet neuroinformatics core Seminars Ped Neurol 18(1):17-20

374. Lupien S, Parent S, Evans AC, Tremblay R, Zelazo P, Corbo V, Pruessner J, Séguin J (2011) Larger amygdala but no change in hippocampal volume in 10 year old children exposed to maternal depressive symptomatology since birth Proc Natl Acad Sci USA 108(34):14324-9

375. van Haren NE, Schnack HG, Cahn W, van den Heuvel MP, Lepage C, Collins L, Evans AC, Hulshoff Pol HE, Kahn RS (2011) Changes in cortical thickness during the course of illness in schizophrenia Arch Gen Psychiatry 68(9):871-80

376. Oishi K, Hao H, Takashi Y,Ying SH, Zee DS, Zilles K, Amunts K, Woods R, Toga AW, GB, Rosa-Neto P, Evans AC, van Zijl PCM, Mazziotta, Mori S (2011) Superficially located white matter structures commonly seen in the human and the macaque brain with diffusion tensor imaging Brain Connectivity 1(1):37-47

377. Wu K, Taki Y, Sato K, Sassa Y, Inoue K, Goto R, Okada K, Kawashima R, He Y, Evans AC, Fukuda H (2011) The overlapping community structure of structural brain network in young healthy individuals. PLoS One 6(5):e19608

378. Bolduc ME, Du Plessis AJ, Evans A, Guizard N, Zhang X, Robertson RL, Limperopoulos C (2011) Cerebellar malformations alter regional cerebral development Dev Med Child Neurol 53(12): 1128-34

379. Das S, Zijdenbos AP, Vins D, Harlap J, Evans AC (2011) LORIS: A web-based data

68 68 management system for multi-center studies Front Neuroinf 5:37

380. Wu K, Taki Y, Sato K, Kinomura S, Goto R, Okada K, Kawashima R, He Y, Evans AC, Fukuda H (2012) Age-related changes in topological organization of structural brain networks in healthy individuals Hum Brain Mapping 33(3): 552-68

381. Clouchoux C, Kudelski D, Gholipour A, Warfield SK, Viseur S, Bouyssi-Kobar M, Mari J-L, Evans AC, Du Plessis AJ, Limperopoulos C (2012) Quantitative in vivo MRI measurement of cortical development in the fetus Brain Structure Function 217(1): 127—39

382. Clouchoux C, Guizard N, Evans AC, Du Plessis AJ, Limperopoulos C (2012) Normative fetal brain growth by quantitative in vivo magnetic resonance imaging Am J Obst and Gynecol 206(2):173.e1—8

383. Fahim C, Yoon U, Nashaat NH, Khalil AK, El-Belbesy M, Mancini-Marie A, Evans AC, Meguid N (2012) Williams syndrome: a relationship between genetics, brain morphology and behavior J Intellect Disabil Res 56(9): 879—94

384. Gong G, He Y, Chen ZJ, Evans AC (2012) Convergence and divergence of cortical thickness correlations with anatomical connections in the human cerebral cortex Neuroimage 59(2):1239-48

385. de Laat KF, Reid AT, Grim D, Evans AC, Kötter R, van Norden AGW, de Leeuw F-E (2012) Patterns of cortical thickness are related to gait disturbances in cerebral small vessel disease Neuroimage 59(2):1478-84

386. Meguid NA, Fahim C, Sami R, Nashaat NH, Yoon U, Anwar M, El-Dessouky HM, Shahine EA, Ibrahim AS, Mancini-Marie A, Evans AC (2012) Cognition and lobar morphology in full mutation boys with fragile X syndrome Brain Cogn 78(1): 74-84

387. Brain Development Cooperative Group (2012) Total and regional brain volumes in a population-based normative sample from 4 to 18 years: the NIH MRI Study of Normal Brain Development Cereb Cortex 22(1): 1-12

388. Tohka J, He Y, Evans AC (2012) Impact of sapling density upon cortical network analysis: Regions or points ? Magnetic Resonance Imaging 30(7): 978-92

389. Ducharme S, Hudziak JJ, Botteron KN, Albaugh MD, Nguyen TV, Karama S, Evans AC & Brain Development Cooperative Group (2012) Decreased regional cortical thickness and thinning rate are associated with inattention symptoms in healthy children J Am Acad Child Adolesc Psychiatry 51(1):18-27

390. van Soelen IL, Brouwer RM, van Baal GC, Schnack HG, Peper JS, Collins DL, Evans AC, Kahn RS, Boomsma DI, Pol HE (2012) Genetic influences on thinning of the cerebral cortex during development Neuroimage 59(4): 3871-90

391. Evans AC, Janke AL, Collins DL, Baillet S (2012) Brain templates and atlases Neuroimage 62(2): 911-22

392. Yin X, Zhao L, Xu J, Evans AC, Fan L, Ge H, Tang Y, Khundrakpam B, Wang J, Liu S (2012) Anatomical substrates of the alerting, orienting and executive control components of attention: focus on the posterior parietal lobe PLoS One. 2012;7(11): e50590

393. Shaw P, Gilliam M, Malek M, Rodriguez N, Greenstein D, Clasen L, Evans A, Rapoport J, Giedd J (2012) Parental age effects on cortical morphology in offspring Cereb Cortex 22(6):1256-62

69 69 394. Wolff JJ, Gu H, Gerig G, Elison JT, Styner M, Gouttard S, Botteron KN, Dager SR, Dawson G, Estes AM, Evans AC, Hazlett HC, Kostopoulos P, McKinstry RC, Paterson SJ, Schultz RT, Zwaigenbaum L, Piven J (2012) Differences in white matter fiber tract development present from 6 to 24 months in infants with autism Am J Psychiatry 169(6): 589-600

395. Bellec P, Lavoie-Courchesne S, Dickinson P, Lerch J, Zijdenbos A, Evans AC (2012) The pipeline system for Octave and Matlab (PSOM): a lightweight scripting framework and execution enginefor scientic workflows Front Neuroinf 6:7

396. Hulshoff Pol HE, van Baal GC, Schnack HG, Brans RG, van der Schot AC, Brouwer RM, van Haren NE, Lepage C, Collins DL, Evans AC, Boomsma DI, Nolen W, Kahn RS (2012) Overlapping and segregating structural brain abnormalities in twins with schizophrenia or bipolar disorder Arch Gen Psychiatry 69(4): 349—59

397. Fahim C, Meguid, NA, Nashaat, NH, Yoon U, Mancini-Marie A, Evans AC (2012) The neuroanatomy of the autistic phenotype Res Autism Spectrum Disorders 6(2): 898—906

398. Waber DP, Forbes PW, Almli CR, Blood EA & Brain Development Cooperative Group (2012) Four-year longitudinal performance of a population-based sample of healthy children on a neuropsychological battery: the NIH MRI study of normal brain development J Int Neuropsychol Soc 18(2): 179-90

399. Hazlett HC, Gu H, McKinstry RC, Shaw DW, Botteron KN, Dager SR, Styner M, Vachet C, Gerig G, Paterson SJ, Schultz RT, Estes AM, Evans AC, Piven J and the IBIS Network (2012) Brain volume findings in 6-month-old infants at high familial risk for autism Am J Psych169(6): 601-8

400. Riera JJ, Ogawa T, Goto T, Sumiyoshi A, Nonaka H, Evans A, Miyakawa H, Kawashima R (2012) Pitfalls in the dipolar model for the neocortical EEG sources J Neurophysiol 108(4):956-7

401. Yoon U, Perusse D, Evans AC (2012) Mapping genetic and environmental influences on cortical surface area of pediatric twins Neuroscience 220:169-78

402. Buchy L, Ad-Dab'bagh Y, Lepage C, Malla A, Joober R, Evans A, Lepage M (2012) Symptom attribution in first episode psychosis: A cortical thickness study Psychiatry Res 203(1): 6-13

403. Shaw P, Malek M, Watson B, Sharp W, Evans A, Greenstein D (2012) Biol Psychiatry Development of cortical surface area and gyrification in attention-deficit/hyperactivity disorder 72(3):191-7

404. Nguyen T-V, Ducharme S, Botteron KN, McCracken J, Mahabir M, Israel M, Evans AC, Karama S & Brain Development Cooperative Group (2013) Testosterone-related cortical maturation across childhood and adolescence Cerebral Cortex 23(6): 1424-32

405. Tremblay S, De Beaumont L, Henry LC, Boulanger Y, Evans AC, Bourgouin P, Poirier J, Théoret H, Lassonde M (2013) Sports concussions and aging: A neuroimaging investigation Cereb Cortex 23(5): 1159-66

406. Lepage JF, Clouchoux C, Lassonde M, Evans AC, Deal CL, Théoret H (2013) Abnormal motor cortex excitability is associated with reduced cortical thickness in X monosomy Hum Brain Mapp 34(4):936-44

407. Albaugh MD, Ducharme S, Collins DL, Botteron KN, Althoff RR, Evans AC, Karama S, Hudziak JJ and the Brain Development Cooperative Group (2013) Evidence for a cerebral cortical thickness network anti-correlated with amygdalar volume in healthy youths: Implications for the neural substrates of emotion regulation Neuroimage 71: 42-9

70 70

408. Kim SH, Fonov VS, Dietrich C, Vachet C, Hazlett HC, Smith RG, Graves MM, Piven J, Gilmore JH, Dager SR, McKinstry RC, Paterson S, Evans AC, Collins DL, Gerig G, Styner MA and the IBIS network (2013) Adaptive prior probability and spatial temporal intensity change estimation for segmentation of the one-year-old human brain J Neurosci Methods 212(1): 43-55

409. Reid AT and Evans AC (2013) Structural networks in Alzheimer's disease Eur Neuropsychopharmacol 3(1): 63-77

410. Wu K, Taki Y, Sato K, Hashizume H, Sassa Y, Takeuchi H, Thyreau B, He Y, Evans AC, Li X, Kawashima R, Fukuda H (2013) Topological organization of functional brain networks in healthy children: Differences in relation to age, sex, and intelligence PLoS One. 2013;8(2):e55347

411. Evans AC (2013) Networks of anatomical covariance Neuroimage 80:489-504

412. Farzinfar M, Oguz I, Smith RG, Verde AR, Dietrich C, Gupta A, Escolar ML, Piven J, Pujol S, Vachet C, Gouttard S, Gerig G, Dager S, McKinstry RC, Paterson S, Evans AC, IBIS network, Styner MA (2013) White matter microstructure and atypical visual orienting in 7-month-olds at risk for autism Am J Psychiatr 170(8):899-908

413. Amunts K, Lepage C, Borgeat L, Mohblerg H, Dickscheid T, Rousseau M-E, Bludau S, Bazin P- L, Lewis LB, Oros-Peusquena A-M, Shah NJ, Lippert T, Zilles K, Evans AC (2013) The Big Brain – an ultra-high resolution 3D human brain model Science 340(6139): 1472-5

414. Farzinfar M, Oguz I, Smith RG, Verde AR, Dietrich C, Gupta A, Escolar ML, Piven J, Pujol S, Vachet C, Gouttard S, Gerig G, Dager S, McKinstry RC, Paterson S, Evans AC and the IBIS network (2013) Diffusion imaging quality control via entropy of principal direction distribution Neuroimage 82C: 1-12

415. Lewis JD, Theilmann RJ, Fonov V, Bellec P, Lincoln A, Evans AC, Townsend J (2013) Callosal fiber length and interhemispheric connectivity in adults with autism: Brain overgrowth and underconnectivity Hum Brain Mapp 34(7):1685-95

416. Khundrakpam BS, Reid A, Brauer J, Carbonell F, Lewis J, Ameis S, Karama S, Lee J, Chen Z, Das S, Evans AC and Brain Development Cooperative Group (2013) Developmental changes in organization of structural brain networks Cereb Cortex 23(9):2072-85

417. Elison JT, Paterson SJ, Wolff JJ, Reznick JS, Sasson NJ, Gu H, Botteron KN, Dager SR, Estes AM, Evans AC, Gerig G, Hazlett HC, Schultz RT, Styner M, Zwaigenbaum L, Piven J; IBIS Network (2013) White matter microstructure and atypical visual orienting in 7-month-olds at risk for autism Am J Psychiatry 170(8):899-908

418. Casey KF, Cherkasova MV, Larcher K, Evans AC, Baker GB, Dagher A, Benkelfat C, Leyton M (2013) Individual differences in frontal cortical thickness correlate with the d-amphetamine-induced striatal dopamine response in humans J Neurosci 33(38): 15285-94

419. Yu L, Xie B, Yin X, Liang M, Evans AC, Wang J, Dai C (2013) Reduced cortical thickness in primary open-angle glaucoma and its relationship to the retinal nerve fiber layer thickness PLoS One 8(9):e73208

420. Nguyen TV, McCracken JT, Ducharme S, Cropp BF, Botteron KN, Evans AC, Karama S (2013) Interactive effects of dehydroepiandrosterone and testosterone on cortical thickness during early brain development J Neurosci 33(26): 10840-8

421. Karama S, Bastin ME, Murray C, Royle NA, Penke L, Maniega SM, Gow AJ, Corley J, Valdés

71 71 Hernández MdC, Lewis JD, Rousseau M-E, Lepage C, Fonov V, Collins DL, Rioux P, Sherif T, Adalat R, Starr JM, Evans AC, Wardlaw JM, Deary IJ (2012) Childhood cognitive ability explains associations between cognitive ability and brain cortical thickness in old age Molecular Psychiatry (in press, PMID: 23732878)

422. Zhao L, Boucher M, Rosa-Neto P, Evans AC (2013) Impact of scale space search on age- and gender-related changes in MRI-based cortical morphometry Hum Brain Mapp 34(9): 2113-28

423. Walker L, Curry M, Nayak A, Lange N, Pierpaoli C & Brain Development Cooperative Group (2012) A framework for the analysis of phantom data in multicenter diffusion tensor imaging studies Hum Brain Mapp 34(10):2439-54

424. Clouchoux C, du Plessis AJ, Bouyssi-Kobar M, Tworetzky W, McElhinney DB, Brown DW, Gholipour A, Kudelski D, Warfield SK, McCarter RJ, Robertson RL Jr, Evans AC, Newburger JW, Limperopoulos C (2012) Delayed cortical development in fetuses with complex congenital heart disease Cereb Cortex (in press, PMID: 22977063)

425. Ducharme S, Albaugh MD, Hudziak JJ, Botteron KN, Nguyen TV, Truong C, Evans AC, Karama S and the Brain Development Cooperative Group (2013) Anxious/depressed symptoms are linked to right ventromedial prefrontal cortical thickness maturation in healthy children and young adults Cereb Cortex (in press, PMID: 23749874)

426. Bregant T, Rados M, Vasung L, Derganc M, Evans AC, Neubauer D, Kostovic I (2013) Region- specific reduction in brain volume in young adults with perinatal hypoxic-ischaemic encephalopathy Eur J Paediatr Neurol (in press, PMID: 23746926)

427. MacDonald PA, Ganjavi H, Evans AC, Karama S & Brain Development Cooperative Group Investigating the relation between striatal volume and IQ Brain Imaging Behav (in press, PMID: 23813349)

428. Ameis SH, Ducharme S, Albaugh MD, Hudziak JJ, Botteron K, Lepage C, Zhao L, Khundrakpam B, Collins DL, Lerch JP, Wheeler A, Schachar R, Evans AC, Karama S (2013) Cortical thickness, cortico-amygdalar networks and externalizing behaviors in healthy children Biol Psychiatry (in press, PMID: 23890738)

429. Zhou D, Lebel C, Evans A, Beaulieu C (2013) Cortical thickness asymmetry from childhood to older adulthood Neuroimage 83C: 66-74

430. Karama S and Evans AC (2013) Neural correlates of attention-deficit/hyperactivity disorder in adulthood Biol Psychiatry 74(8): 558-9

431. Truong W, Minuzzi L, Soares CN, Frey BN, Evans AC, Macqueen GM, Hall GB (2013) Changes in cortical thickness across the lifespan in major depressive disorder Psychiatry Res (in press: PMID: 24099630)

432. Lewis JD, Theilmann RJ, Townsend J, Evans AC (2014) Network efficiency in autism spectrum disorder and its relation to brain overgrowth Front Neurosci (in press)

433. Yu L, Xie B, Yin X, Liang M, Evans AC, Wang J, Dai C (2013) Reduced cortical thickness in primary open-angle glaucoma and its relationship to the retinal nerve fiber layer thickness PLoS One 8(9):e73208 (in press, PMID: 24019910)

434. Chouinard-Decorte F, McKay DR, Reid A, Khundrakpam B, Zhao L, Karama S, Rioux P, Sprooten E, Knowles E, Kent Jr. JW, Curran JE, Go ̈ring HHH, Dyer TD, Olvera RL, Kochunov P, Duggirala R, Fox PT, Almasy L, Blangero J, Bellec P, Evans AC, Glahn DC (2014) Heritable

72 72 changes in regional cortical thickness with age Brain Imag Behav (in press)

435. Albaugh MD, Ducharme S, Karama S, Watts R, Nguyen T-V, McKinstry RC, Botteron KN, Evans AC, Hudziak JJ (2014) Increased fiber tract organization is associated with anxious/depressed symptoms in typically developinh youths Biological Psychiatry (in press)

436. Carbonell F, Charil A, Zijdenbos AP, Evans AC, Bedell BJ (2014) A unified framework for different thresholding approaches in brain networks J Cereb Blood Flow Metabol (in press)

437. Sherif T, Rioux P, Rousseau M-E, Kassis N, Beck N, Glatard T, Adalat R, Das S, Evans AC (2014) CBRAIN: A web-based, distributed computing platform for collaborative neuroimaging research Frontiers of Neuroscience (in press)

Bibliography - Peer-Reviewed Conference Papers

1. Frouin V, Reilhac A, Evans AC, Grégoire MC (2000) Comparison between an image- and a sinogram- based correction algorithm for partial volume effect in 3D PET imaging Proc IEEE Nucl Sci 3(18): 57– 61

2. Reilhac A, Rousset OG, Comtat C, Frouin V, Grégoire MC, Evans AC (2000) A correction algorithm for partial volume effects in 3D PET imaging: Principle and validation Proc IEEE Nucl Sci 3(18): 62–66

3. Thiel A, Reilhac A, Collins DL, Rousset OG, Neelin P, Evans AC (2001) Volume-of-interest based automatic partial volume correction for large numbers of PET datasets Proc BrainPET 2001: 121-129, Eds Sendai M, Herscovitch P

4. Reilhac A, Thiel A, Frouin V, Collins DL, Rousset O, Evans AC (2001) Automated partial volume correction: simulation-based assessment of errors J Cereb Blood Flow Metab 21

5. Cocosco CA, Zijdenbos AP, Evans AC (2002) Automatic generation of training data for brain tissue classification from MRI Proc 4st. International Conference on Medical Computing and Computer- Assisted Intervention (MICCAI), LNCS 2488: 516–523

6. Sechet S, Reilhac A, Gunn R, Evans AC, Dagher A (2002) Frame misalignment-induced errors in PET studies: an investigation on strategies for correction Proc IEEE Nucl Sci 2: 1330–1334

7. Reilhac A, Lartizien C, Costes N, Sans S, Comtat C, Evans AC (2002) Accounting for single rates related phenomena in PET Monte Carlo-based simulations Proc IEEE Nucl Sci 3: 1617–1621

8. Chung MK, Worsley KJ, Evans AC (2003) Tensor-based brain surface modeling and analysis Proc IEEE Computer Soc. Conference on Computer Vision and Pattern Recognition 1: I467-473

9. Reilhac A, Batan G, Michel C, Costes N, Evans AC (2004) PET-SORTEO: a platform for simulating realistic PET studies Proc IEEE Nucl Sci 7: 4053– 4057

10. Batan G, Reilhac A, Grova C, Collins L, Tohka J, Costes N, Evans AC (2004) A database of simulated PET volumes with anatomical variability Proc IEEE Nucl Sci 6: 3699–3702

11. Perruchot F, Reilhac A, Grova C, Evans AC, Dagher A (2004) Motion correction of multi-frame PET data,” Proc IEEE Nucl Sci 5: 3186–3190

12. Chung MK, Robbins S, Evans AC (2005) Unified statistical approach to cortical thickness analysis Inf Process Med Imaging 19:627-38

73 73

13. Worsley KJ, Charil, A, Lerch, J, Evans AC (2005) Connectivity of anatomical and functional MRI data IEEE International Joint Conference onNeural Networks, IJCNN '05

14. Lartizien C, Goertzen A, Reilhac A, Costes N, Magnin I, Gimenez G, Evans AC (2005) Validation of SORTEO monte carlo simulations for the geometry of the Concorde MicroPET R4 system Proc IEEE Nucl Sci

15. Aubert-Broche B, Grova C, Reilhac A, Evans AC, Collins DL (2006) Realistic simulated MRI and SPECT databases. Application to SPECT/MRI registration evaluation.Med Image Comput Comput Assist Interv (MICCAI’06) 9(1):330-7

16. Fu L, Fonov V, Pike B, Evans AC, Collins DL.(2007) Automated analysis of multi site MRI phantom data for the NIHPD project Med Image Comput Comput Assist Interv(MICCAI) 9(Pt 2):144-51

17. Schottlander D, Guimond A, Brady M, Declerck J, Collins L, Evans AC, Reilhac A (2006) Development and use of a kinetic FDG-PET dataset simulated from the MNI standard brain, SPIE Medical Imaging 6143:

18. Chung MK, Robbins S, Dalton KM, Wang S, Evans AC, Davidson RJ (2006) Tensor-based cortical morphometry via weighted spherical harmonic representation In IEEE Computer Society Workshop on Mathematical Methods in Biomedical Image Analysis (MMBIA)

19. Boucher M, Lyttelton O, Whitesides S, Evans AC (2007) A Discrete Differential Operator for Direction- based Surface Morphometry Proc International Conference on Computer Vision (ICCV 2007)

20. Chakravarty MM, Rosa-Neto P, Broadbent S, Evans AC, Collins DL (2008) Development of fMRI techniques for planning in functional neurosurgery for Parkinson’s Disease Vth IEEE International Symposium on Biomedical Imaging (ISBI'08) (in press)

21. Besson P, Bernasconi N, Colliot O, Evans AC, Bernasconi.A (2008) Surface-based texture and morphological analysis detects subtle cortical dysplasia Med Image Comput Comput Assist Interv(MICCAI) 11(Pt 1):645-52

22. Clouchoux C, Coupé P, Manjon JV, Guizard N, Bouyssi-Kobar M, Lefebvre M, du Plessis A, Evans AC, Limperopoulos C (2011) In-vivo fetal brain study: Automated high-resolution volume reconstruction and cortical surface extraction ?

23. Lavoie-Courchesne S, Rioux P, Chouinard-Decorte F, Sherif T, Rousseau M-E, Das S, Adalat R, Doyon J, Craddock C, Margulies D, Chu C, Lyttelton O, Evans AC, Bellec P (2012) Integration of a neuroimaging processing pipeline into a pan-Canadian computing grid J Physics: Conference Series 341 (1), 012032+. URL http://dx.doi.org/10.1088/1742-6596/341/1/012032

24. Glatard T, Rousseau M-E, Rioux P, Adalat R, Evans AC (2014) Controlling the deployment of virtual machines on clusters and clouds for scientific computing in CBRAIN CCGrid4 (in press)

Bibliography - Papers submitted

1. Lee JK, Fonov V, Almli R, McKinstry R, Collins DL, Evans AC & Brain Development Cooperative Group Longitudinal growth analysis of early childhood brain using deformation- based morphometry (Submitted April 2009)

74 74 2. Lewis JD, Evans AC, Pruett J, Botteron K, Zwaigenbaum L, Estes A, Gerig G, Collins L, Kostopoulos P, McKinstry R, Dager S, Paterson S, Schultz R, Styner, M, Hazlett H, Piven J for the IBIS network (2014) Network inefficiencies in infants with ASD (submitted July 2013)

3. Zhou D, Lebel C, Treit S, Evans A, Beaulieu C (2014) Extensive and Accelerated Longitudinal Cortical Thinning in Adolescence (submitted November 2013)

4. Amunts K, Hawrylycz MJ, Van Essen DC, Van Horn JD, Harel N, Poline J-B, De Martino F, Bjaalie JG, Dehaene-Lambertz G, Dehaene S, Valdes-Sosa P, Thirion B, Zilles K, Abrams MB, Tass PA, Vanduffel W, Evans AC, Eickhoff SB (2014) Interoperable atlases of the human brain (submitted February 2014)

75 75 Bibliography - Books

1. Schmahmann JD, Doyon J, Toga AW, Evans AC, Petrides M (2000) MRI atlas of the human cerebellum Publishers: Academic Press

Bibliography - Book Chapters

1. North ACT, Denson AK, Evans AC, Ford LO, Willoughby TV (1980) The use of an interactive computer graphics system in the study of protein conformations Biomolecular structure, conformation, function and evolution, Vol. 1 - Diffraction and related studies: Pergamon Press (Oxford) ; Editor, R Srinivasan

2. North ACT, Chabot AA, Evans AC, Geddes AJ (1981) The use of an interactive computer display system in the study of inter-molecular interactions in Structural Aspects of Recognition and Assembly in Biological Macromolecules: Balaban ISS (Rehovot) ; Eds. Balaban M, Sussman JL, Traub W, Yonath A

3. Yamamoto YL, Ochs R, Gloor P, Ammann W, Meyer E, Evans AC, Cooke B Izawa M, Kato A, Feindel W, Diksic M, Thompson CJ (1983) Patterns of rCBF and focal energy metabolic changes in relation to electroencephalographic abnormality in the interictal phase of partial epilepsy Proceedings of the International Symposium on Cerebral Blood Flow, Metabolism and Epilepsy. In: Cerebral Blood Flow, Metabolism and Epilepsy. M. Baldy-Moulinier (ed.), John Libbey (London): 51-62

4. Yamamoto YL, Hakim AM, Diksic M, Pokrupa RP, Meyer E, Tyler JL, Evans AC, Worsley K, Thompson CJ, Feindel W (1985) Focal flow disturbances in acute strokes: effects on regional metabolism and tissue pH XIIIth World Congress of Neurology, Hamburg, Sept. 1-6, 1985. In: Functional Mapping of the Brain in Vascular Disorders. (Ed. W.D. Heiss). Springer-Verlag, Berlin, Heidelberg, New York, 85-105

5. Gjedde A, Beil C, Meyer E, Evans AC, Hakim AM (1988) Density of capillaries in regions of the living human brain affected by stroke in Cerebral Hyperemia and Ischemia: From the standpoint of cerebral blood volume. Editors Tomita, Sawada, Naritomi, Heiss ; Excerpta Medica, Amsterdam: 91-102

6. Gjedde A, Kuwabara H, Berger L, Beil C, Evans AC, Hakim AM (1989) Density of functioning cerebral capillaries in stroke patients, determined by PET in Cerebral Ischemia and Calcium. Editors: Hartmann A, Kuchinsky W. Springer-Verlag, Berlin-Heidelberg (in press)

7. Gjedde A and Evans AC (1989) PET studies of domoic acid poisoning in humans: Excitotoxic destruction of brain glutamatergic pathways, revealed in measurements of glucose metabolism by positron emission tomography in Proceedings of the Symposium on Domoic Acid Toxicity, Ottawa

8. Peters TM, Collins DL, Evans AC (1992) Image segmentation and 3-D applications in The physics of magnetic resonance imaging. Proceedings of AAPM summer school, Banff, Sept. 1992

9. Kamber M, Shinghal R, Evans AC, Collins DL, Francis GS (1994) Experiments in the automated detection of multiple sclerosis brain lesions in magnetic resonance images Proc IXth IEEE Conference on Artificial Intelligence for Applications: 32–43

10. Evans AC (1993) 3-D Multi-modality human brain mapping: Past, Present and Future in Quantification of Brain Function: Tracer kinetics and image analysis in brain PET, pp. 373–

76 76 390 : eds. K. Uemura, N. Lassen, T. Jones, I Kanno

11. Rousset OG, Ma Y, Leger G, Gjedde A, Evans AC (1993) Correction for partial volume effect in PET using MRI-based 3-D simulations of individual human brain metabolism in Quantification of Brain Function: Tracer kinetics and image analysis in brain PET, pp. 113–126 : eds. K. Uemura, N. Lassen, T. Jones, I Kanno

12. Fujita H, Meyer E, Kuwabara H, Evans AC, Gjedde A (1993) Comparison of O-15 water blood flow activation PET studies with (K1-map) and without (CBF-map) inclusion of a vascular compartment Quantification of Brain Function: Tracer kinetics and image analysis in brain PET, pp. 609– 618 : eds. K. Uemura, N. Lassen, T. Jones, I Kanno

13. Worsley K, Evans AC, Marrett S, Neelin P (1993) Detecting and estimating the regions of activation in CBF activation studies in human brain Quantification of Brain Function: Tracer kinetics and image analysis in brain PET, pp. 535–548 : eds. K. Uemura, N. Lassen, T. Jones, I Kanno

14. S Marrett, Fujita J, Ribeiro L, Kuwabara H, Meyer E, Evans AC, Gjedde A (1993) Evidence for stimulus-specific changes in oxidative metabolism Quantification of Brain Function: Tracer kinetics and image analysis in brain PET, pp. 217–228 : eds. K. Uemura, N. Lassen, T. Jones, I Kanno

15. Ribeiro L, Kuwabara H, Meyer E, Fujita H, Marrett S, Evans AC, Gjedde A (1993) Cerebral Blood flow and metabolism during non-specific bilateral visual stimulation in normal subjects Quantification of Brain Function: Tracer kinetics and image analysis in brain PET, pp. 229– 236 : eds. K. Uemura, N. Lassen, T. Jones, I Kanno

16. Evans AC, Peters TM, Collins DL, Neelin P, Gabe C(1993) Image Registration based on discrete anatomical structures in Interactive Image-Guided Neurosurgery ; AANS Publications, ed: R. Maciunas: 63–80

17. Evans AC, Kamber M, Collins DL, MacDonald D (1994) An MRI-based probabilistic atlas of neuroanatomy in Magnetic Resonance Scanning and Epilepsy: NATO ASI Series A, Life Sciences volume 264: Eds. S Shorvon, D Fish, F Andermann, GM Bydder, H Stefan: Plenum Press, New York: 263–274

18. Peters TM, Evans AC, Olivier A (1994) Frameless stereotaxy: Technical aspects in Magnetic Resonance Scanning and Epilepsy: NATO ASI Series A, Life Sciences volume 264: Eds. S Shorvon, D Fish, F Andermann, GM Bydder, H Stefan: Plenum Press, New York: 155–160

19. Cendes F, Andermann F, Gloor P, Olivier A, Evans AC, Peters TM (1994) The role of MRI volumetric studies in the investigation of patients with intractable epilepsy in Magnetic Resonance Scanning and Epilepsy: NATO ASI Series A, Life Sciences volume 264: Eds. S Shorvon, D Fish, F Andermann, GM Bydder, H Stefan: Plenum Press, New York: 57–62

20. Watson C, Andermann F, Gloor P, Cendes F, Jones-Gotman M, Peters T, Evans AC, Olivier A, Melanson D, Leroux G, Williamson B (1994) Advances in morphometric and volumetric analysis in temporal lobe epilepsy in Magnetic Resonance Scanning and Epilepsy: NATO ASI Series A, Life Sciences volume 264: Eds. S Shorvon, D Fish, F Andermann, GM Bydder, H Stefan: Plenum Press, New York: 47–56

21. Evans AC, Collins DL, Neelin P, MacDonald D, Kamber M, Marrett TS (1994) Three-dimensional Correlative Imaging: Applications in Human Brain Mapping in Advances in NeuroImaging: Multimodal Registration, Eds: R Thatcher, M Hallett, T Zeffiro, ER John, M Huerta : 145– 162

77 77 22. Evans AC (1995) Multi-modality correlation and analysis in Principles of Nuclear Medicine eds: H. Wagner, Zsabo Z, Buchanan J: 405–421

23. Peters TM, Henri CJ, Evans AC, Takahashi AM, Munger P, Olivier A (1995) Integration of stereoscopic DSA and 3-D MRI for image-guided neurosurgery in, Neurosurgical Imaging, ed: R. von Hanwehr (in press)

24. Evans AC, Collins DL, Neelin P, Marrett TS (1995) Correlative Analysis of 3-D Brain Images in Computer Integrated Surgery, ed: S. Lavalèe and R. Mosges (in press)

25. Klein D, Zatorre R, Milner B, Meyer E, Evans AC (1995) The neural substrates underlying bilingual language processing: Evidence from positron emission tomography Aspects of Bilingual Aphasia : Ed. M Paradis

26. Worsley KJ, Marrett S, Neelin P, Evans AC (1995) A unified statistical approach for determining significant signals in location and scale space images of cerebral activation in Quantification of Brain Function: Tracer kinetics and image analysis in brain PET, pp. 327–332 : eds. R. Myers, V. Cunningham, D. Bailey, T. Jones

27. Evans AC, Collins DL, Holmes CJ (1995) Automatic 3D regional MRI segmentation and statistical probabibility anatomy maps in Quantification of Brain Function: Tracer kinetics and image analysis in brain PET, pp. 123–130 : eds. R. Myers, V. Cunningham, D. Bailey, T. Jones

28. Rousset OG, Ma Y, Marenco S, Wong DF, Evans AC (1995) In-vivo correction for partial volume effects in PET: Accuracy and precision 29. in Quantification of Brain Function: Tracer kinetics and image analysis in brain PET, pp. 158–165 : eds. R. Myers, V. Cunningham, D. Bailey, T. Jones

30. Murase K, Kuwabara H, Vafaee M, Toussaint PJ, Gjedde AH, Evans AC, Meyer E (1995) Generation of maps of dispersion time constant and tracer arrival delay using 15O-carbon monoxide in Quantification of Brain Function: Tracer kinetics and image analysis in brain PET, pp. 421–424 : eds. R. Myers, V. Cunningham, D. Bailey, T. Jones

31. Evans AC (1995) Summary of Statistics Session in Quantification of Brain Function: Tracer kinetics and image analysis in brain PET, 434–437: eds. R. Myers, V. Cunningham, D. Bailey, T. Jones

32. Evans AC, Collins DL, Holmes CJ (1996) Toward a probabilistic atlas of human neuroanatomy Brain Mapping: The Methods ; eds. J.C. Mazziotta and A.W. Toga ; Publ. Academic Press

33. Mazziotta J, Toga A, Evans AC, Fox PT, Lancaster J Atlases of the human brain Neuroinformatics: An overview of the Human Brain Project ; eds: SH Koslow and MF Huerta: 255–308

34. Collins DL and Evans AC (1999) ANIMAL: Automatic nonlinear image matching and anatomical labeling in Brain Warping ; eds. A.W. Toga and J.C. Mazziotta ; Academic Press 133–142

35. Ma Y, Rousset O, Neelin P, Evans AC, Dhawan V, Eidelberg D. Validation of a dynamic PET simulator in clinical brain studies (2000) In: Physiological Imaging of the Brain with PET. Gjedde A, Hansen SB, Knudsen GM, Paulson OB, editors. San Diego: Academic Press 3-8

36. Evans AC (2001) Automated 3D analysis of large brain MRI databases in ACNP Fifth Generation of Progress : eds. Dennis Charney, Joseph Coyle, Kenneth Davis, Charles Nemeroff: 301–313

37. Boucher M, Evans AC, Siddiqi K (2011) Texture manifold for curve-based morphometry of the cerebral cortex Medical Computer Vision: Recognition Techniques and Applications in Medical

78 78 Imaging174—183

38. Boucher M and Evans AC (2012) Local statistics on shape diffeomoprhisms using a depth potential function in Computational Imaging and Vision 41: Mathematical methods for signal and image analysis and representation, eds: Florack L, van Lieshout M-C, Duits R, Davies L, Jongbloed G ; Springer-Verlag London

Bibliography – Abstracts (terminated entries in 2001)

1. Evans AC and North ACT (1977) The use of an interactive computer graphics system in the study of protein conformations Abstracts of 4th European Crystallography Meeting A: 11 2. Evans AC and Chabot AA (1979) The use of an interactive computer graphics system in the study of molecular structure British Biophysical Symposium ,Wye College, London 3. North ACT, Denson AK, Evans AC, Ford LO, Willoughby TV (1979) The use of an interactive computer graphics system in the study of protein conformations Proceedings of the Indian Biophysical Society 4. Evans AC (1983) Error analysis of Sokoloff, Phelps and Brooks models for quantification of glucose utilization with FDG 2nd Annual MNI-PET Meeting, Montebello 5. Evans AC (1983) Calibration of the Therascan 3128 PET scanner 2nd Annual MNI-PET Meeting, Montebello 6. Evans AC, Cooke BE, Yamamoto YL, Thompson CJ (1983) Initial imaging of glucose and oxygen metabolism from the Therascan 3128 PET tomograph 2nd Annual MNI-PET Meeting, Montebello 7. Pokrupa R, Hakim A, Yamamoto YL, Kitamura S, Diksic M, Thompson CJ, Meyer E, Evans A and Feindel W (1984) Acute cerebral infarction: PET, CT and pathological correlates Royal College of Physicians and Surgeons of Canada 8. Hakim A, Pokrupa R, Kitamura S, Evans AC, Diksic M, Yamamoto YL, Feindel W (1984) PET studies of circulation, energy metabolism and acid-base status after acute cerebral infarction in man XIX Canadian Congress of Neurological Sciences, Edmonton, Alberta 9. Hakim A, Pokrupa R, Kitamura S, Yamamoto YL, Meyer E, Diksic M, Thompson CJ, Evans AC, Feindel W (1984) Acute cerebral infarction in man: Studies of cerebral circulation metabolism and acid-base status by PET 109th Annual Meeting of the American Neurological Association, Baltimore 10. Strother SC, Tyler JL, Peters TM, Thompson CJ, Evans AC, Diksic M, Meyer E, Yamamoto YL, Feindel W (1985) An inter-center comparison of region of interest and resolution effects for normal F- 18 fluorodeoxyglucose: Positron emission tomography in young healthy controls J Cereb Blood Flow Metabol 5, Supplement 1 : S607-8 11. Meyer E, Yamamoto YL, Evans AC, Tyler JL, Diksic M, Feindel W (1985) Radiation dose to the trachea from inhaled oxygen-15 labelled carbon dioxide J. Nucl Med 26: 62 12. Tyler JL, Strother SC, Diksic M, Evans AC, Thompson CJ, Yamamoto YL Meyer E, Feindel W (1985) An inter-center comparison of quantitative F-18 fluorodeoxyglucose: Positron emission tomography in young healthy controls XII International Symposium on Cerebral Blood Flow and Metabolism, Lund, June 16-20 13. Tyler JL, Theron J, Villemure JG, Peters TM, Evans AC, Yamamoto YL, Diksic M, Ethier R, Feindel W (1985) Super-selective intra-arterial chemotherapy of high-grade gliomas: correlation with PET, MRI and CT International Meeting on Magnetic Resonance in Cancer 14. Hakim A, Pokrupa R, Diksic M, Evans AC, Thompson CJ, Meyer E, Yamamoto YL, Feindel W (1985) Correlation of the size of infarction with cerebral infusion and metabolism. A positron emission tomography (PET) study

79 79 XXth Canadian Congress of Neurological Sciences, Montreal 15. Pokrupa R, Hakim A, Yamamoto YL, Evans AC, Diksic M, Meyer E, Feindel W (1985) Disturbances of oxygen and glucose metabolism in acute human cerebral infarction studied by positron emission tomography XXth Canadian Congress of Neurological Sciences, Montreal 16. Strother SC, Thompson CJ, Evans AC, Dagher A, Lupton LR (1985) Choosing a ring diameter for a PET scanner: A question of slice width IEEE Nuclear Science Symposium 17. Diksic M, Tyler JL, Evans AC, Kirikae M, Meyer E, Yamamoto YL, Villemure J-G and Feindel W (1985) Fluorodeoxyglucose rate constants and oxidative metabolism in primary gliomas measured with PET SNM Computer Instrumentation and Radiopharmaceutical Science Council March 3-5, 1096. West Palm Beach 18. Diksic M, Tyler J, Evans AC, Kirikae M, Meyer E, Yamamoto YL, Villemure J-G, Feindel W (1986) FDG rate constants and oxidative metabolism in gliomas Symposium on Metabolic Imaging with NMR, SPECT and PET. J Nucl Med 27: 735 19. Diksic M, Tyler J, Evans AC, Kirikae M, Meyer E, Yamamoto YL, Villemure J-G, Feindel W (1986) Metabolic studies of untreated brain gliomas with PET Proceedings of the 4th symposium on medical applications of cyclotrons: Turku, Finland 20. Redies C, Diksic M, Matsuda H, Evans AC, Meyer E, Yamamoto YL (1986) Double-label deoxyglucose method for sequential measurement of cerebral glucose utilization. Theory, fluorodeoxyglucose rate constants and validation in the whisker-stimulated rat Soc Neurosc Abstr 12: 179, 50.11 21. Tyler JL, Diksic M, Villemure J-G, Evans AC, Yamamoto YL, Feindel W (1986) Metabolic and hemodynamic studies of gliomas using positron emission tomography J Nucl Med 27(6): 889 22. Strother SC, Evans AC, Thompson CJ (1986) Using flood phantoms to evaluate quantification in PET J Nucl Med 27(6): 1024 23. Tyler JL, Diksic M, Villemure J-G, Evans AC, Yamamoto YL, Feindel W (1986) Metabolic and hemodynamic studies of gliomas using positron emission tomography (PET) XXIst Canadian Congress of Neurological Sciences, London, in Canadian Journal of Neurological Sciences 13(2): 170 24. Diksic M, Tyler J, Evans AC, Kirikae M, Meyer E, Yamamoto YL, Villemure J-G, Feindel W (1986) Measurements of the metabolism of primary gliomas with PET Canadian meeeting of Neuro-oncology: Montreal, Canada 25. Thompson CJ, Dagher A, Lunney DN, Strother SC, Evans AC (1986) A technique to reject scattered radiation in PET transmission scans International Workshop on Physics and Engineering of Computerized Multidimensional Image Processing, Newport Beach, California 26. Pokrupa R, Hakim A, Villanueva J, Meyer E, Diksic M, Evans A (1986) PET evaluation of blood flow and metabolic changes induced by PGI2 therapy in patients with ischemic stroke XXIst Canadian Congress of Neurological Sciences, London, in Canadian Journal of Neurological Sciences 13(2): 188 27. Evans AC, Redies C, Gauthier S, Tyler JL, Diksic M, Meyer E, Yamamoto YL, Hakim A (1986) PET study of metabolic and hemodynamic coupling in Huntington’s Disease Society of Nuclear Medicine Symposium 28. Evans AC, Redies C, Gauthier S, Tyler JL, Diksic M, Meyer E, Yamamoto YL, Hakim A (1986) Study of metabolic and haemodynamic coupling in Huntington’s Disease by positron emission tomography XX1st Canadian Congress of Neurological Sciences, London, in Canadian Journal of Neurological Sciences 13(2): 179 29. Jovkar S, Nakai H, Evans AC, Diksic M and Yamamoto YL (1986) Influence of temporal sampling on the accuracy of parameter estimation in the deoxyglucose method Society of Nuclear Medicine Symposium

80 80 30. Pokrupa R, Marchal G, Evans AC, Hakim A (1987) Spontaneous CMRO2 changes in stroke: the associated metabolic and perfusion characteristics J Cereb Blood Flow Metabol 7(1): S55 31. Marchal G, Evans AC, Dagher A, Meyer E, Hakim AM (1987) The evolution of cerebral infarction with time: A PET study of the ischemic penumbra J Cereb Blood Flow Metabol 7(1): S99 32. Berger L, Marchal G, Evans AC, Hakim AC (1987) A preliminary PET evaluation of nimodipine in stroke J Cereb Blood Flow Metabol 7(1): S160 33. Evans AC (1987) A double integral form of the three-compartmental, four rate-constant model for faster generation of parameter maps J Cereb Blood Flow Metabol 7(1): S453 34. Jovkar S, Evans AC, Diksic M, Yamamoto L (1987) Determination of optimal scan schedules and validation of an empirical tissue noise model in PET dynamic studies J Cereb Blood Flow Metabol 7(1): S454 35. Phillips PC, Moeller JR, Dhawan V, Sergi M, Strother SC, Ginos JZ, Evans AC, Rottenberg DA (1987) Reduced white matter glucose metabolism following whole-brain irradiation in long-term survivors of childhood acute lymphocytic leukemia J Cereb Blood Flow Metabol 7(1): S460 36. Redies C, Diksic M, Evans AC, Gjedde A, Yamamoto YL (1987) Theoretical basis for double- label autoradiographic deoxyglucose method J Cereb Blood Flow Metabol 7(1): S479 37. Hakim AM, Evans AC, Marchal G, Meyer E, Diksic M, Dagher A (1987) The evolution of the ischemic penumbra with time. A PET study J Nucl Med 28: 633 38. Allard CD, Strother SC, Evans AC (1987) Analytic scatter correction as a function of object size and spatial position J Nucl Med 28: 695 39. Strother SC, Allard C, Evans AC, Thompson CJ (1987) Selecting contrast phantoms to evaluate systematic errors in ECT J Nucl Med 28: 698 40. Evans AC, Beil C, Marrett S (1987) MRI-PET Correlation using an adjustable ROI atlas J Nucl Med 28(6): 1071 41. Berkovic SF, Evans AC et al. (1987) Cerebral metabolic abnormalities in a mitochondrial encephalomyopathy demonstrated by positron emission tomography Neurology 37 (Supplement 1): 135-6 42. Gjedde A, Beil C, Meyer E, Evans AC, Hakim AM (1987) Density of capillaries in regions of the living human brain affected by stroke Satellite Symposium, Brain Section, 4th World Congress for Microcirculation, Osaka, Japan 43. Kitamura S, Yamamoto YL, Hakim A, Evans AC, Meyer E, Kato A, Pokrupa R (1988) Patterns of physiological and biochemical changes in acute human cerebral infarction with and without hyperglycemia studied with positron emission tomography International Symposium: Clinical Applications of Radionuclide studies of the brain Am J Physiol Imag 3(1) 50 44. Evans AC, Beil C, Marrett S, Thompson CJ, Hakim AM (1988) MRI-PET Correlation using an adjustable ROI atlas World Congress of Medical Physics and Biomedical Engineering 45. Evans AC, Beil C, Kuwabara H, Meyer E, Marrett S, Redies C, Mitsuka S, Hakim AM (1988) Reduced inter-observer variability in ROI analysis of PET images using MRI-based templates 35th Society of Nuclear Medicine Symposium: San Francisco 46. Kuwabara H, Gjedde A, Beil C, Meyer E, Evans AC, Diksic M, Hakim AM (1988) Density of cerebral capillaries studied in stroke patients with positron emission tomography 35th Society of Nuclear Medicine Symposium: San Francisco 47. Matthews P, Evans AC, Andermann FE, Hakim AM, Andermann E(1988) Local cerebral glucose metabolism differs in the adult and rigid juvenile forms of Huntington’s disease

81 81 XXIIIrd Canadian Congress of Neurological Sciences 48. Hoffer LJ, Redies C, Beil C, Marliss EB, Evans AC, Lariviere F, Marrett S, Meyer E, Diksic M, Hakim AM (1988) Brain glucose metabolism during fasting in man studied by positron emission tomography Society of Neuroscience Symposium, Toronto 49. Meyer E, Zatorre RJ, Evans AC, Alivisatos B, Marrett S (1988) Reproducibility of regional cerebral blood flow measurements in normal subjects with and without auditory stimulation Society of Neuroscience Symposium 50. Thompson CJ, Ranger N, Evans AC (1988) Simultaneous transmission and emission scans in positron emission tomography IEEE Nuclear Science Symposium 51. Marrett S, Evans AC, Collins DL, Peters TM (1988) Three-dimensional MRI-PET correlative imaging in the human brain Radiological Society of North America meeting, November, 1988 52. Collins DL, Peters TM, Marrett S, Henri C, Evans AC (1988) Integration of stereoscopic angiography data with volume rendered three-dimensional CT and MR images Radiological Society of North America meeting, Chicago, 1988 53. Peters TM, Evans AC, Collins DL, Marrett S, Henri C, Pike B (1988) Multi-modality 3-D brain imaging Digital Imaging Technology for Oncology Workshop, Vancouver 54. Marrett S, Evans AC, Peters TM (1989) A volume of interest (VOI) atlas for analysis of neurophysiological image data Annual Symposium of the International Society of Optical Engineering (SPIE): Medical Imaging III, Newport Beach 55. Evans AC, Marrett S, Peters TM (1989) Anatomical-functional correlative analysis of the human brain using three-dimensional imaging systems Annual Symposium of the International Society of Optical Engineering (SPIE): Medical Imaging III, Newport Beach 56. Henri C, Collins DL, Peters TM, Evans AC (1989) Three-dimensional interactive display of medical images for stereotactic neurosurgery planning Annual Symposium of the International Society of Optical Engineering (SPIE): Medical Imaging III, Newport Beach 57. Meyer E, Ferguson S, Zatorre R, Dykes RW, Alivisatos B, Evans AC, Diksic M, Hakim AM (1989) Attention enhances human somatosensory CBF response to vibrotactile stimulation as measured by PET J Cerebral Blood Flow and Metabolism, 9, Suppl. 1, S579 58. Evans AC, Nathens A, Hogan M, Collins DL, Marrett S, Hakim A (1989) An interactive computerized region-of-interest atlas of the rat brain International Symposium on Cerebral Blood Flow and Metabolism, Bologna, Italy 59. Evans AC, Marrett S, Collins DL, Peters TM (1989) Anatomical-functional correlative imaging in three dimensions International Symposium on Cerebral Blood Flow and Metabolism, Bologna, Italy 60. Gjedde A, Evans AC, Teitelbaum J, Diksic M, Zatorre R, Cashman N, Hakim AM (1989) Domoic acid intoxication in humans: an in vivo model of excitotoxic destruction of brain glutamatergic pathways J Cerebral Blood Flow and Metabolism, 9, Suppl. 1, S517 61. Delpla P, Meyer E, Zatorre R, Melancon D, Alivisatos B, Marrett S, Evans AC, Ethier R, Petrides M, Diksic M, Ptito A, Jones-Gotman M, Bes A, Hakim A (1989) Metabolic and neuropsychological correlates of periventricular lucencies J Cerebral Blood Flow and Metabolism, 9, Suppl. 1, S569 62. Hakim AM, Berger L, Kuwabara H, Worseley K, Marchal G, Beil C, Evans AC, Diksic M, Meyer E (1989) The effect of nimodipine treatment on the evolution of human cerebral infarction studied by PET J Cerebral Blood Flow and Metabolism, 9, Suppl. 1, S5? ? 63. Peters T, Pike B, Clark J, Collins DL, Henri C, Evans AC, Marrett S, Olivier A, Jeppsson O

82 82 (1989) Multi-modality 3-D imaging for stereotactic surgery planning 3rd Int. Symposium on Computer Assisted Radiology, Berlin 64. Thompson CJ, Ranger NT, Evans AC (1989) Simultaneous emission and transmission scans in PET using a masked orbiting transmission source (MOTS) Society of Nuclear Medicine Symposium, St. Louis 65. Evans AC, Thompson CJ, Marrett S, Weltman R, Holte S (1989) Performance characteristics of a high-resolution PET scanner for brain imaging in three dimensions Society of Nuclear Medicine Symposium, St. Louis 66. Evans AC, Marrett S, Collins DL, Peters T (1989) A customizable volume-of-interest (VOI) atlas for three dimensional PET data analysis Society of Nuclear Medicine Symposium, St. Louis 67. Marrett S and Evans AC (1989) Evaluation of a PET-MRI volume matching algorithm Society of Nuclear Medicine Symposium, St. Louis 68. Marrett S, Collins DL, Evans AC, Peters T (1989) A tool for volumetric PET/MRI image matching and display Society of Nuclear Medicine Symposium, St. Louis 69. Thompson CJ, Ranger NT, Evans AC (1989) Simultaneous acquisition of PET emission and transmission scans using a masked orbiting transmission source Annual Symposium of Canadian Association of Physicists, Division of Medical and Biological Physicists, London 70. Marrett TS, Collins DL, Pike GB, Ku S, Peters TM, Evans AC (1989) Volumetric MRI/PET image correlation, display and analysis 8th Annual Symposium of the Society of Magnetic Resonance in Medicine, Amsterdam, Netherlands 71. Peters TM, Henri CJ, Collins DL, Evans AC, Marrett S (1989) Three-dimensional visualization of medical images from multiple modalities Engineering and the Physical Sciences in Medicine EPSM-89, Hamilton, New Zealand 72. Thompson CJ, Marrett TS, Evans AC (1989) Performance evaluation of the Scanditronix PC2048B 15-slice PET scanner Annual Symposium of Canadian Association of Physicists, Division of Medical and Biological Physicists, London 73. Marrett TS, Torrescorzo J, Collins DL, Ku S, Evans AC (1989) A three-dimensional brain atlas for PET-MRI image analysis Radiological Society of North America, Annual Meeting, Chicago 74. Thompson CJ, Evans AC, Marrett TS, Meyer E, Mazza M, Holte S, Weltman R, Ericsson T (1989) Performance evaluation of the Scanditronix PC-2048B 15-slice PET scanner IEEE Nuclear Science Symposium, October, San Francisco 75. Peters TM, Evans AC, Marrett S, Collins DL (1989) Three-dimensional anatomical- physiological image correlation using a volume-of-interest atlas Lowenthal Lecture, Australasian Society of Nuclear Medicine Symposium, Christchurch, New Zealand 76. G Francis, L Baer, P Ahmed, B Pike, AC Evans, J Antel (1990) Effect of MRI slice thickness on measurement of multiple sclerosis lesion volume American Academy of Neurology, Miami, May 1990 77. Talbot JD, Marrett S, Evans AC, Meyer E, Bushnell MC, Duncan GH (1990) PET-measured cortical activity in humans during noxious heat stimulation Society for Neuroscience Annual Symposium, St Louis, October 1990 78. Marrett S, Bub D, Chertkow H, Meyer E, Gum T, Evans AC (1990) Functional neuroanatomy of visual single words processing studied with PET/MRI Society for Neuroscience Annual Symposium, St Louis, October 1990 79. Evans AC, Peters TM, Marrett S, Collins DL, Pike GB, Henri C, Dai W (1990) 3-D correlative imaging and segmentation of cerebral anatomy, function and angiography NATO Advanced Research Workshop: 3D Imaging in Medicine, Travemunde, June 1990 80. Bub D, Chertkow H, Evans AC, Meyer E (1990) Positron Emission tomographic studies of normal cognition

83 83 Canadian Psychological Association Symposium on Brain and Behavior, Ottawa, June 1990 81. Evans AC, Peters T, Collins DL, Henri C, Marrett S, Pike B, Dai W (1990) 3-D correlative imaging and segmentation of cerebral anatomy, function and vasculature 12th Annual International Conference of IEEE Engineering in Medicine and Biology Society, Philadelphia, June 1990 82. Leblanc R, Meyer E, Bub D, Zatorre R, Evans AC (1991) Pre-operative speech mapping with positron emission tomography American Association of Neurological Surgeons Annual Convention New Orleans 83. Meyer E, Leblanc R, Bub D, Zatorre RJ, Evans AC (1991) Functional activation PET scanning and 3-dimensional brain mapping in patients with cerebral arteriovenous malformations J Cerebral Blood Flow and Metabolism, 11, Suppl. 1, S396 84. Dai W, Marrett S, Collins DL, Evans AC (1991) Three-dimensional non-linear warping of a computerized volume-of-interest brain atlas for morphometric analysis XVth International Symposium on Cerebral Blood Flow and Metabolism, Miami 85. Evans AC, Gum T, Marrett S, Neelin P, Milot S, Meyer E, Bub D (1991) Three dimensional analysis of averaged cognitive activation PET and MRI images in stereotaxic coordinate space XVth International Symposium on Cerebral Blood Flow and Metabolism, Miami 86. Sergent J, Zuck E, Moreno-Cantu J, Meyer E, Evans AC, Diksic M, Ohta S, Gjedde A (1991) Combined PET and MRI investigation into the processing of faces XVth International Symposium on Cerebral Blood Flow and Metabolism, Miami 87. Bub D, Evans AC, Meyer E, Chertkow H, Marrett S (1991) The Role of Temporal Cortex in Single Word Recognition: Anatomical Mapping of Functional Activation XVth International Symposium on Cerebral Blood Flow and Metabolism, Miami 88. Chertkow H, Bub D, Evans AC, Meyer E, Marrett S (1991) Functional activation of frontal cortex in sub-vocalization Annual Symposium, American Academy of Neurology, Boston, April 1991 89. Worsley KJ, Evans AC, Marrett S, Neelin P (1991) Maxima of random fields with an application to positron emission tomography images 3rd Canadian Conference in Applied Statistics, Concordia University, May 1991 90. Worsley KJ, Evans AC, Marrett S, Neelin P (1991) Maxima of random fields with an application to positron emission tomography images Statistical Society of Canada Annual Meeting, Toronto, June 1991 91. Chertkow H, Bub D, Evans AC, Meyer E, Marrett S (1991) Neural correlates of picture processing studied with positron emission tomography Symposium on Theoretical and Experimental Neuropsychology (TENNET), Montreal, June 1991 92. Zatorre RJ, Evans AC, Meyer E (1991) Regional cerebral blood flow activation during processing of speech International Biological Research Organization (IBRO) Annual Symposium, p. 179 93. Chertkow H, Bub D, Evans AC, Meyer E, Dekter M, Dixon R, Zahirney G (1991) Functional and anatomical dissociations in semantic memory processing demonstrated with positron emission tomography International Biological Research Organization (IBRO) Annual Symposium, Montreal, August 1991 94. Evans AC, Neelin P, Marrett S, Meyer E, Dai W, Collins DL (1991) Combined stereotactic mapping of MRI and PET studies of cognitive activation in human brain Annual Symposium of the IEEE Engineering in Medicine and Biology Society, Orlando, October 1991 95. Worsley KJ, Evans AC, Marrett S, Neelin P (1991) Random field theory applied to PET subtrction image analysis Biennial meeting of the Statistical Computing and Biological Statistics Sections of the Statistical Society of Australia, Coolangatta, Queensland, Australia, June 1991 96. Pelizzari CA, Evans AC, Neelin P, Chen C-T, Marrett S (1991) Comparison of two methods for 3D registration of PET and MRI images Annual Symposium of the IEEE Engineering in Medicine and Biology Society, Orlando, November 1991

84 84 97. Watson C, Andermann F, Gloor P, Jones-Gotman M, Peters T, Evans AC, Olivier A, Leroux G (1991) MRI-based volume measurement of the hippocampus and amygdaloid body: Description of method and preliminary normal control data American Epilepsy Society Annual Symposium 98. Petrides M, Alivisatos B, Evans AC, Meyer E (1991) Task-specific modulation of cerebral blood flow within the human frontal cortex Annual Symposium, Society for Neuroscience, November 1991 99. Francis G, Collins DL, Hum S, Antel J, Evans A (1991) Serial MRI evaluation of MS lesion volume International Federation of Multiple Sclerosis Societies Annual Meeting, Amsterdam, October 1991 100. Leblanc R, Meyer E, Zatorre R, Bub D, Evans AC (1991) Language localization with activation positron emission tomography Proc. American Epilepsy Society Annual Symposium, Epilepsia 33(Supplement 3): 120 101. Collins DL, Dai W, Marret S, Evans AC (1991) Three-dimensional warping of a computerized volume-of-interest brain atlas for morphometric analysis Annual Conference of IPMI (Information Processing in Medical Imaging), Wye College, U.K. 102. Gjedde A, Kuwabara H, Reith J, Benkelfat C, Leger G, Rajagopal S, Diksic M, Evans AC (1991) PET assays of enzyme activity in the living human brain: Application to DOPA decarboxylase International Society of Neurochemistry, Sydney, Australia, July 1991 103. Benkelfat C, Bradwejn J, Meyer E, Ellenbogen M, Milot S, Gjedde A, Evans AC (1991) Neuroanatomical correlates of CCK4-induced panic attacks in normal healthy volunteers: a 15 determination of regional CBF changes using PET and the O-H2O bolus method Annual symposium, American College of Neuropsychopharmacology (ACNP) 104. Evans AC, Worsley KJ, Marrett S, Neelin P (1992) Analysis of PET activation images: When is a peak not a peak ? Annual meeting, McDonnell-Pew Cognitive Neuroscience Program 105. Benkelfat C, Bradwejn J, Meyer E, Ellenbogen M, Milot S, Gjedde A, Evans AC (1992) CBF changes during CCK4-induced panic in normals Annual symposium, Society of Biological Psychiatry, Washington, April 1992 106. Benkelfat C, Bradwejn J, Meyer E, Ellenbogen M, Milot S, Gjedde A, Evans AC (1992) Neuroanatomical correlates of CCK4-induced panic in normals Collegium International Psychopharmacologicum (CINP), Nice, July 1992 107. Cendes F, Andermann F, Watson C, Evans AC, Gloor P, Melancon D, Jones-Gotman M, Leroux G, Olivier A, Peters T (1992) Volumetric measurements of amygdaloid body (AB) and hippocampal formation (HF) in temporal lobe epilepsy (TLE) American Academy of Neurology Annual Symposium, San Diego, May 1992 108. Jones-Gotman M, Cendes F, Andermann F, Gloor P, Evans AC, Andermann E, Melancon D, Leroux G, Olivier A, Peters T (1992) Correlation of history of prolonged febrile convulsions and temporal lobe epilepsy (TLE) with volumetric measures of amygdaloid body (AB) and hippocampal formation (HF) American Academy of Neurology Annual Symposium, San Diego, May 1992 109. Leblanc R, Meyer E, Bub D, Zatorre R, Evans AC (1992) Activation PET scanning for the assessment of cerebral AVMs Proc. XXVIIth Canadian Congress of Neurological Sciences, Canadian Journal of Neurological Science 19: 258 110. Cendes F, Andermann F, Watson C, Evans AC, Gloor P, Jones-Gotman M, Melancon D, Olivier A, Leroux G, Peters T (1992) MRI volumetric measurements of amygdaloid body and hippocampal formation: inter- and intra-rater differences XXVIIth Canadian Congress of Neurological Sciences 111. Cendes F, Andermann F, GLoor P, Lopes-Cendes I, Olivier A, Evans AC, Melancon D, Jones- Gotman M, Peters T (1992) Mesial temporal atrophy: cause or consequence of repeated seizures ? Evidence from computerized MRI volumetric studies XXVIIth Canadian Congress of Neurological Sciences

85 85 112. Francis G, Evans AC, Collins DL, Antel J (1992) Quantitative MRI measurement of lesion load in chronic progressive (CP) and relapsing-remitting (RR) sub-types of multiple sclerosis American Academy of Neurology Annual Symposium, San Diego, May 1992 113. Ma Y, Rousset OG, Kamber M, Evans AC (1992) MRI-based simulation of PET images Annual Symposium American Association of Physicists in Medicine, Calgary, August 1992 114. Collins DL, Peters TM, Evans AC (1992) Automatic multiresolution registration of MRI volumetric data Annual Symposium, Society of Magnetic Resonance (SMRM) in Medicine, Berlin, July 1992 115. Coghill RC, Talbot J, Evans AC, Gjedde A, Meyer E, Duncan GH, Bushnell MC (1992) Human Cerebral Processing of Noxious and Innocuous Stimuli Proc 22nd Annual Symposium, Society for Neuroscience, Anaheim 167.11 : 386 116. Evans AC, DL Collins, Milner B (1992) An MRI-based stereotactic brain atlas from 300 young normal subjects Proc 22nd Annual Symposium, Society for Neuroscience, Anaheim 179.4 : 408 117. Paus T, Petrides M, Evans AC, Meyer E (1992) Somatotopy within the human anterior cingulate cortex: Mapping of higher-order motor control 158th Annual Meeting of the American Association for the Advancement of Science : 251 118. Paus T, Petrides M, Evans AC (1992) Task-specific changes of local blood flow in the human anterior cingulate cortex: relationship to the level of performance Proc 22nd Annual Symposium, Society for Neuroscience, Anaheim 397.5 : 939 119. Zatorre RJ, Jones-Gotman M, Evans AC, Meyer E (1992) Functional localization of human olfactory cortex with positron emission tomography Proc 22nd Annual Symposium, Society for Neuroscience, Anaheim 394.5 : 933 120. Ptito A, Zatorre R, Petrides M, Frey S, Alivisatos B, Evans AC (1992) PET study of stereopsis Proc 22nd Annual Symposium, Society for Neuroscience, Anaheim 585.6 : 1394 121. S Marrett, Fujita J, Kuwabara H, Yasuhara Y, Ribeiro L, Meyer E, Evans AC, Gjedde A (1992) Stimulus specific increase of oxidative metabolism in visual cortex Proc 22nd Annual Symposium, Society for Neuroscience, Anaheim 585.7 : 1394 122. Rousset OG, Ma Y, Kamber M, Evans AC (1992) Simulation of striatal 18F-fluoroDOPA uptake: Sensitivity of quantitative estimates to axial position Proceedings of IEEE Symposium on Advanced Medical Image Processing in Medicine: 167–172 123. Neelin P, Crossman J, Hawkes D, Ma Y, Evans AC (1992) Evaluation of MRI/PET registration using simulated PET brain images Proceedings of IEEE Symposium on Advanced Medical Image Processing in Medicine: 73–78 124. Ma Y, Rousset OG, Evans AC (1992) Three-dimensional MRI-based simulation of PET images Proceedings of IEEE Symposium on Advanced Medical Image Processing in Medicine: 141–146 125. Collins DL, Peters TM, Evans AC (1992) Non-linear multi-scale image registration and segmentation of individual brain structures from MRI Proceedings of IEEE Symposium on Advanced Medical Image Processing in Medicine: 105–110 126. Chertkow H, Hamel E, Bub D, Waters G, Meyer E, Evans AC, Whitehead V (1992) Increased anterior cingulate activation during cognitive processing in Alzheimer’s Disease patients Proceedings of 117th Annual Symposium, American Neurological Association (Toronto, October 1992) P31 : 30 127. Cendes F, Andermann F, Lopes-Cendes I, Andermann E, Evans AC, Peters T (1992) Atrophy of mesial temporal structures in patients with temporal lobe epilepsy (TLE): Cause or consequence ? Proc. American Epilepsy Society Annual Symposium, Epilepsia 33(Supplement 3): 71 128. Cendes F,Leproux F, Andermann F, Melancon D, Evans AC, Peters T, Ethier R (1992) Amygdalo-hippocampal structures in temporal lobe epilepsy: Comparison between volumetric studies and visual MRI evlauation Proc. American Epilepsy Society Annual Symposium, Epilepsia 33(Supplement 3): 50 129. Cukiert A, Olivier A, Cendes F, Andermann F, Evans AC, Melancon D (1992) Quantified resection and outcome in the surgical treatment of temporal lobe epilepsy: A study based on application of a temporal grid Proc. American Epilepsy Society Annual Symposium, Epilepsia 33(Supplement 3): 92 130. Leblanc R, Meyer E, Zatorre R, Bub D, Evans AC (1992) Language localization with activation-

86 86 positron emission tomography Proc. American Epilepsy Society Annual Symposium, Epilepsia 33(Supplement 3): 120 131. Chertkow H, Hamel E, Bub D, Meyer E, Wisbord S, Evans AC, D’Antono B (1992) Increased activation of anterior cingulate region in dementia of the Alzheimer’s type Neurology 42, Suppl. 3: 316 132. Chertkow H, Bub D, Evans AC, Whitehead V, D’Antono B, Decter M, Milot S (1992) Functional Imaging of Stages in Picture Naming Demonstrated with Positron Emission Tomography Proceedings of the Academy of Aphasia 30th Annual Meeting: 75 133. Chertkow HM, Bub D, Waters G, Evans AC, Whitehead V Hosein C (1993) Separate effects of instructions and stimuli on cerebral blood flow: An 15O positron emission tomographic study Neurology 43: A189 134. Zatorre RJ, Evans AC, Meyer E (1993) Functional activation of right temporal and occipital cortex in processing tonal melodies J Acoust Soc Amer 93 (4 , pt. 2): 2364 135. Perry DW, Alivisatos B, Evans AC, Meyer E, Petrides M, Zatorre RJ (1993) Neural network supporting auditory-vocal integration in singing J Acoust Soc Am 93(4, pt. 2): 2403 136. Fujita J, Meyer E, Kuwabara H, Evans AC, Gjedde A (1993) Cerebral blood flow and oxidative metabolism remain uncoupled during chronic vibrotactile stimulation in humans J Cereb Blood Flow Metab 13(suppl 1): 798 137. Evans AC (1993) 3-D Multi-modality human brain mapping: Past, Present and Future Ann Nucl Med 7: S13 138. Rousset OG, Ma Y, Leger G, Gjedde A, Evans AC (1993) Correction for partial volume effect in PET using MRI-based 3-D simulations of individual human brain metabolism Ann Nucl Med 7: S31 139. Fujita H, Meyer E, Kuwabara H, Evans AC, Gjedde A (1993) Comparison of O-15 water blood flow activation PET studies with (K1-map) and without (CBF-map) inclusion of a vascular compartment Ann Nucl Med 7: S96 140. Worsley K, Evans AC, Marrett S, Neelin P (1993) Detecting and estimating the regions of activation in CBF activation studies in human brain Ann Nucl Med 7: S108 141. S Marrett, Fujita J, Ribeiro L, Kuwabara H, Meyer E, Evans AC, Gjedde A (1993) Evidence for stimulus-specific changes in oxidative metabolism Ann Nucl Med 7: S120 142. Ribeiro L, Kuwabara H, Meyer E, Fujita H, Marrett S, Evans AC, Gjedde A (1993) Cerebral Blood flow and metabolism during non-specific bilateral visual stimulation in normal subjects Ann Nucl Med 7: S122 143. Rousset OG, Ma Y, Léger G, Evans AC (1993) In vivo correction for resolution effects in human positron emission tomography Annual Symposium, American Association of Physicists in Medicine & Canadian Organization of Medical Physicists, June 1993 144. Zhang Y, Ma Y, Evans AC (1993) Image reconstruction using anatomical information for positron emission tomography Annual Symposium, American Association of Physicists in Medicine & Canadian Organization of Medical Physicists, June 1993 145. Evans AC and Collins DL (1993) A 305-member MRI-based stereotactic atlas for CBF activation studies 40th Society of Nuclear Medicine (SNM) Syposium, Toronto, June 1993 146. Ma Y, Kamber M, Rousset OG, Evans AC (1993) A 3-D simulation algorithm for PET imaging based on 3-D computerized brain phantoms from MRI data 40th Society of Nuclear Medicine (SNM) Syposium, Toronto, June 1993 147. Rousset OG, Ma Y, Léger G, Kuwabara H, Gjedde AH, Evans AC (1993) Effects of limited PET resolution on dynamic radiotracer uptake: Simulation studies 40th Society of Nuclear Medicine (SNM) Syposium, Toronto, June 1993

87 87 148. Fujita H, Kuwabara H, Evans AC, Meyer E, Gjedde AH (1993) Regionally differential vascular reactivity to vibrotactile stimulation of right fingers J Nucl Med 34: 57 Collins DL, Fu L, Pioro E, Evans AC, Arnold DL Generation of average metabolite images from MRSI in stereotaxic space Annual Symposium, Society of Magnetic Resonance (SMRM) in Medicine, , August 1993 149. Perry DW, Petrides M, Alivisatos B, Zatorre R, Evans AC, Meyer E (1993) Functional activation of human frontal cortex during tonal working memory Proc 23rd Annual Symposium, Society for Neuroscience 150. Zatorre RJ, Evans AC, Meyer E (1993) Cortical mechanisms underlying melodic perception and working memory for pitch Society Neurosci Abs 19: 843 151. Jones-Gotman M, Zatorre R, Evans AC, Meyer E (1993) Functional activation of right hippocampus during an olfactory recognition memory task Society Neurosci Abs 19: 1002 152. Paus T, Tomaiuolo F, Petrides M, Evans AC (1993) Spatial relationship between physiologically-defined cingulate hand representation and MRI-defined course of the cingulate sulcus Proc 23rd Annual Symposium, Society for Neuroscience 153. Coghill RC, Morin C, Evans AC, Meyer E, Gjedde A, Duncan GH, Bushnell MC (1993) Cerebral blood flow (CBF) during tonic pian in man Proc 23rd Annual Symposium, Society for Neuroscience 154. Tomaiuolo F, Paus T, Morris R, MacDonald D, Petrides M, Evans AC (1993) Inter-individual variability of the sulcal pattern in the anterior cingulate region Proc 23rd Annual Symposium, Society for Neuroscience 155. Cendes F, Andermann F, Carpenter S, Evans AC Gjedde A, Teitelbaum J, Zatorre RJ, Cashman NR (1993) Temporal lobe epilepsy (TLE) caused by domoic acid intoxication: Evidence for glutamate receptor-mediated excitotoxicity in man XVIIIth Canadian Congress of Neurological Sciences 156. Cendes F, Andermann F, Gloor P, Evans AC, Peters T, Lopes-Cendes I, Andermann E, Olivier A (1993) MRI volumetric study: insights into the etiology of temporal lobe epilepsy XVIIIth Canadian Congress of Neurological Sciences 157. Fujita J, Kuwabara H, Meyer E, Marrett S, Evans AC, Diksic M, Gjedde A (1993) Oxidative Phosphorylation studied with PET 6th Symposium on the Medical Applications of Cyclotrons: (submitted May 1992) 158. Meyer E, Fujita H, Marrett S, Ribiero L, Kuwabara H, Evans AC, Gjedde AH (1993) Cerebral blood flow and oxidative metabolism during physiological stimulation studied with positron emission tomography 2nd Gauss Symposium, Munich , August 1993 Kamber M, Collins DL, Narayanan S, Pioro E, Evans AC, Arnold DL Probability Models in Standardized Brain Space and the Classification of MS Plaques in MRI Annual Symposium, Society of Magnetic Resonance (SMRM) in Medicine, , July 1993 159. Evans AC, Collins DL, Mills SR, Brown ED, Kelly RL (1993) 3D statistical neuroanatomical models from 305 MRI volumes Annual IEEE Symposium on Medical Imaging, San Francisco, October 1993 160. Jones-Gotman M, Brulot M, McMackin D, Cendes F, Andermann F, Olivier A, Evans AC, Peters T (1993) Word and design-list learning deficits related to side of hippocampal atrophy as assessed by volumetric MRI measurements American Epilepsy Society Annual Symposium 161. Jones-Gotman M, McMackin D, Cendes F, Andermann F, Evans AC, Olivier A, Peters T (1993) Performance on intracarotid sodium amobarbital memory tests: relationship to hippocampal atrophy as estimated by volumetric MRI American Epilepsy Society Annual Symposium 162. Perry DW, Petrides M, Alivisatos B, Zatorre RJ, Meyer E, Evans AC (1993) Monitoring of self- ordered and externally-ordered pitches within auditory working memory Brenda Milner Symposium, Montebello, Canada

88 88 163. MacDonald D, Avis D, Evans AC (1993) Automatic parameterization of human cortical surfaces Proc Annual Symposium on Information Processing in Medical Imaging (IPMI) 164. Lukban AF, Dean G, Lisbona R, Dubeau F, McMackin D, Evans AC (1994) Anatomical localization of seizure foci using registered SPECT/MRI brain volumes Annual Symposium, American Academy of Neurology 165. Paus T, Benkelfat C, Cumming P, Evans AC, Gjedde A, Petrides M (1994) Alpha-methyl-para- tyrosine (AMPT) attenuates task-specific CBF changes in the human anterior cingulate cortex Proc 24th Annual Symposium, Society for Neuroscience, Miami Beach: 166. Bonda E, Petrides M, Frey S, Evans AC (1994) Frontal cortex involvement in organized sequences of hand movements: Evidence from a positron emission tomography study Proc 24th Annual Symposium, Society for Neuroscience, Miami Beach: 353 167. Penhune VB, Zatorre RJ, MaDonald D, Fleischer T, Evans AC (1994) Probabilistic mapping of human auditory cortex in stereotaxic space from 3-D MRI data Proc 24th Annual Symposium, Society for Neuroscience, Miami Beach: 168. Zatorre RJ, Halpern AR, Perry DW, Meyer E, Evans AC (1994) A PET investigation of musical imagery and perception Proc 24th Annual Symposium, Society for Neuroscience, Miami Beach: 169. Perry DW, Petrides M, Zatorre RJ, Evans AC (1994) Increases in CBF within frontal and temporal cortex during perceived, imaged and vocalized musical pitch intervals Proc 24th Annual Symposium, Society for Neuroscience, Miami Beach: 170. Duncan GH, Morin C, Coghill RC, Evans AC, Worsley KJ, Bushnell MC (1994) Using psychophysical ratings to map the human brain: Regression of regional cerebral blood flow (rCBF) to tonic pain perception Proc 24th Annual Symposium, Society for Neuroscience, Miami Beach: 171. Klein D, Milner B, Zatorre R, Meyer E, Evans AC (1994) Functional anatomy of language procesing: A neuroimaging study of word-generation within and across languages Proc 24th Annual Symposium, Society for Neuroscience, Miami Beach: 172. Owen A, Doyon J, Petrides M, Evans AC, Gjedde A (1994) The neural mediation of high-level planning examined using positron emission tomography (PET) Proc 24th Annual Symposium, Society for Neuroscience, Miami Beach: 173. Doyon J, Owen A, Sziklas V, Petrides M, Evans AC (1994) Functional anatomy of visuomotor skill learning using positron emission tomography Proc 24th Annual Symposium, Society for Neuroscience, Miami Beach: 174. Klein D, Milner B, Zatorre R, Meyer E, Evans AC (1994) Functional anatomy of bilingual language procesing: A neuroimaging study Academy of Aphasia Annual Symposium 175. Ouyang X, Pike GB, Evans AC (1994) fMRI of human visual cortex using temporal correlation and spatial coherence analysis 13th Annual Symposium of the Society of Magnetic Resonance in Medicine 176. Bonda E, Petrides M, Evans AC (1994) Mental rotation of body parts studied by positron emission tomography Abstracts of the 17th Annual Meeting of the European Neuroscience Association: Supplement 7 of European J. Neuroscience No.65.15 : 118 177. Rousset OG, Ma Y, Marenco S, Wong DF, Evans AC (1995) MRI-based correction for partial volume effects in positron emission tomography: Validation using a 3-D brain phantom Annual Symposium, American Association of Physicists in Medicine & Canadian Organization of Medical Physicists, June 1995 178. Hoge R, Wolforth M, Evans AC, Pike GB (1995) Acquisition and processing strategies for fMRI at 1.5T Annual Symposium, American Association of Physicists in Medicine & Canadian Organization of Medical Physicists, June 1995 179. Beauregard M, Chertkow H, Murtha S, Evans AC (1995) Neural representations for concrete, abstract and affective word lexica: A positron emission tomography study Symposium on Theoretical and Experimental Neuropsychology (TENNET), Montreal, June 1995 180. Murtha S, Chertkow H, Dixon R, Beauregard M, Evans AC (1995) Anticipation causes increased

89 89 blood flow to the anterior cingulate Annual Symposium, Cognitive Neuroscience Society 181. Paus T, Marrett S, Evans AC, Worsley K (1995) Neurophysiology of saccadic suppression in the human brain Fourth International Biological Research Organization (IBRO) Congress, Kyoto, July 1995 182. Luo S and Evans AC (1995) A method for matching human sulci in 3D space Proceedings of the First International Conference on Functional Mapping of the Human Brain Human Brain Mapping - Supplement 1: 66 183. Perry DW, Zarorre RJ, Petrides M, Evans AC (1995) Cortical activation during tonal working memory tasks in musicians and non-musicians Proceedings of the First International Conference on Functional Mapping of the Human Brain Human Brain Mapping - Supplement 1: 247 184. Bonda E, Petrides M, Frey S, Evans AC (1995) Functional interconnections of insulo-parietal areas sustaining the mental representation of the body Proceedings of the First International Conference on Functional Mapping of the Human Brain Human Brain Mapping - Supplement 1: 274 185. Doyon J, Owen AM, Petrides M, Evans AC (1995) Anatomy of motor skill learning: Effects of the baseline condition and of the implicit versus explicit performance of skill Proceedings of the First International Conference on Functional Mapping of the Human Brain Human Brain Mapping - Supplement 1: 325 186. Owen AM, Evans AC, Petrides M (1995) Evidence for a two-stage model of spatial working memory processing within the lateral frontal cortex: A positron emission tomography study Proceedings of the First International Conference on Functional Mapping of the Human Brain Human Brain Mapping - Supplement 1: 331 187. Leblanc R, Meyer E, Zatorre R, Bub D, Evans AC (1995) Pre-operative functional PET scanning Proceedings of the First International Conference on Functional Mapping of the Human Brain Human Brain Mapping - Supplement 1: 348 188. Paus T, Villemure J-G, Savard G, Ward G, Kuwabara H, Meyer E, Evans AC (1995) Increased cerebral blood flow in the human auditory and visual cortex following bilateral anterior cingulotomy: A single-case study Proceedings of the First International Conference on Functional Mapping of the Human Brain Human Brain Mapping - Supplement 1: 348 189. Bonda E, Petrides M, Evans AC (1995) Insulo-limbic systems for re-memorization through touch: A positron emission tomographix study Proceedings of the 2nd Annual Meeting of the Cognitive Neuroscience Society: 53 190. Otaky N, Paus T, D’Avirro D, Gutmans D, MacDonald D, Caramanos Z, Tomaioulo F, Evans AC (1995) Volumetric analysis of the human cingulate, paracingulate and superior rostral sulci Proc 25th Annual Symposium, Society for Neuroscience, San Diego 67.2 : 154 191. Reutens DC, McHugh MJ, Toussaint PJ, Evans AC, Wolfe LS, Meyer E, Stewart DJ (1995) L- Arginine infusion increases human cerebral blood flow studied with positron emission tomography Proc 25th Annual Symposium, Society for Neuroscience, San Diego 178.1 : 433 192. Zatorre RJ, Perry DW, Beckett C, Evans AC (1995) Functional anatomy of musical processing in listeners with absolute pitch and relative pitch ability Proc 25th Annual Symposium, Society for Neuroscience, San Diego 279.11 : 694 193. Bonda E, Petrides M, Ostry D, Evans AC (1995) Neural correlates of the perception of action in the human parietal cortex Proc 25th Annual Symposium, Society for Neuroscience, San Diego 279.14 : 695 194. Bushnell MC, Craig AD, Reiman E, Yun L.-S., Evans AC (1995) Cerebral activation in the human brain pain, temperature and an illusion of pain Proc 25th Annual Symposium, Society for Neuroscience, San Diego 642.7 : 1637 195. Perry DW, Zatorre RJ, Evans AC (1995) Cortical control of vocal fundamental frequency during singing Proc 25th Annual Symposium, Society for Neuroscience, San Diego 695.3 : 1763 196. Paus T, Zatorre RJ, Gotman J, Caramanos Z, Petrides M, Evans AC (1995) Sustained attention and habituation: A combined PET and EEG study

90 90 Proc 25th Annual Symposium, Society for Neuroscience, San Diego: ? 197. Williamson W, Watson C, Cendes F, Andermann F, Dubeau F, Evans AC (1995) Volumetric MRI in patients with secondary generalized epilepsy American Epilepsy Society Annual Symposium 198. Murase K, Kuwabara H, Ribiero L, Evans AC, Gjedde A (1996) Simplified method for mapping of change in cerebral glucose utilization during physiological stimulation using graphical anlaysis of FDG double injection 43rd Society of Nuclear Medicine Symposium: Denver 199. Murase K, Zhang Y, Ma Y, Evans AC (1996) Usefulness of a newly-developed MRI-constrained PET image reconstruction method 43rd Society of Nuclear Medicine Symposium: Denver 200. Ma Y and Evans AC (1996) Analytic modelling of PET imaging with correlated functional and structural images 43rd Society of Nuclear Medicine Symposium: Denver 201. Yokoi F, Rousset OG, Hong C, Simakhodski I, Chan B, Gjedde A, Evans AC, Wong DF (1996) Correction for partial volume effects on binding potential measurements with human 11C-raclopride PET 43rd Society of Nuclear Medicine Symposium: Denver 202. Murase K, Kuwabara H, Ribeiro L, Gjedde A, Evans AC (1996) Mapping of change in cerebral glucose utilization during physiological stimulation using constrained graphical method of 18F- fluorodeoxyglucose (FDG) double injection Second Annual Conference on Functional Mapping of Human Brain: Boston 203. Small D, Zatorre R, Jones-Gotman M, Petrides M, Evans AC (1996) Flavour processing: More or less than the sum of its parts ? Second Annual Conference on Functional Mapping of Human Brain: Boston 204. Schmahmann J, Doyon J, Holmes CJ, Makris N, Petrides M, Kennedy D, Evans AC (1996) An MRI atlas of the human cerebellum in Talairach space Second Annual Conference on Functional Mapping of Human Brain: Boston 205. Penhune VB, Zatorre RJ, Evans AC (1996) Neural systems underlying temporal perception and timed motor response Second Annual Conference on Functional Mapping of Human Brain: Boston 206. Perry DW, Zatorre RJ, Evans AC (1996) Co-variation of CBF during singing with vocal fundamental frequency Second Annual Conference on Functional Mapping of Human Brain: Boston 207. Owen AM, Milner B, Petrides M, Evans AC (1996) Memory for object-features versus memory for object-location: A positron emission tomography study of encoding and retrieval processes Second Annual Conference on Functional Mapping of Human Brain: Boston 208. Johnsrude IS, Zatorre RJ, Milner BA, Evans AC (1996) A PET study of the processing of rapidly changing acoustic information Second Annual Conference on Functional Mapping of Human Brain: Boston 209. Klein D, Zatorre RJ, Milner B, Johnsrude IS, Nikelski J, Meyer E, Evans AC (1996) CBF patterns during synonym generation: group vs. individual study Second Annual Conference on Functional Mapping of Human Brain: Boston 210. Petrides M, Alivisatos B, Pandya D, Evans AC (1996) Gustatory cortex: comparative architectonic analysis in the human and the macaque brain and functional data Second Annual Conference on Functional Mapping of Human Brain: Boston 211. Holmes CJ, Hoge R, Collins DL, Evans AC (1996) Enhancement of T1 MR images using refistration for signal averaging Second Annual Conference on Functional Mapping of Human Brain: Boston 212. Holmes CJ, Hoge R, Woods RP, Evans AC, Toga AW (1996) Enhancement of T2 and proton density MR images using registration for signal averaging Second Annual Conference on Functional Mapping of Human Brain: Boston 213. Holmes CJ and Evans AC (1996) Braintree: Linking editable hierarchies of anatomical nomenclature with standard 3D imaging space Second Annual Conference on Functional Mapping of Human Brain: Boston

91 91 214. Collins DL and Evans AC (1996) Automatic 3D estimation of gross morphometric variability in human brain Second Annual Conference on Functional Mapping of Human Brain: Boston 215. MacDonald D, Worsley K, Avis D, Evans AC (1996) Surface segmentation and matching by 3D deformation Second Annual Conference on Functional Mapping of Human Brain: Boston 216. Murtha S, Chertkow H, Beauregard M, Gold D, Evans AC (1996) Neuroanatomical correlates of picture naming: A PET study Second Annual Conference on Functional Mapping of Human Brain: Boston 217. Chertkow H, Bub D, Murtha S, Hosein C, Gold D, Evans AC (1996) Word activation and aging: A PET study Second Annual Conference on Functional Mapping of Human Brain: Boston 218. Worsley KJ, MacDonald D, Cao J, Shafie K, Evans AC (1996) Statistical analysis of cortical surfaces Second Annual Conference on Functional Mapping of Human Brain: Boston 219. Poline J-B, Worsley KJ, Evans AC, Friston KJ (1996) Testing for activations using both signal peak intensity and spatial extent Second Annual Conference on Functional Mapping of Human Brain: Boston 220. Bonda E, Petrides M, Ostry D, Evans AC (1996) Interpreting the kinematics of the moving body Second Annual Conference on Functional Mapping of Human Brain: Boston 221. Paus T, Perry DW, Zatorre RJ, Worsley KJ, Evans AC (1996) Modulation of cerebral blood flow in the human auditory cortex during speech: role of motor-to-sensory discharges Second Annual Conference on Functional Mapping of Human Brain: Boston 222. Murtha S, Chertkow H, Beauregard M, Gold D, Evans AC (1996) The neuroanatomy of picture naming: A PET investigation 6th International Annual Rotman Research Conference 223. Chertkow H, Bub D, Murtha S, Beauregard M, Gold D, Hosein C, Evans AC (1996) Variability of brain regions in word processing: evidence for dissociation of processing levels Annual Conference of the Cognitive Neuroscience Society 224. Penhune VB, Zatorre RJ, Evans AC (1996) Cerebellar contributions to motor reproduction of temporal sequences Proc 26th Annual Symposium, Society for Neuroscience, Washington 225. Hofle N, Reutens D, Fiset P, Alonso A, Gotman J, Evans AC, Jones B (1996) Regional cerebral blood flow changes during different stages of sleep in humans studied by positron emission tomography Proc 26th Annual Symposium, Society for Neuroscience, Washington 226. Vafaee M, Marrett S, Paus T, Shoubridge E, Gjedde A, Evans AC, Meyer E (1996) Oxidative metabolism in human visual cortex during physiological activation studied by PET Proc 26th Annual Symposium, Society for Neuroscience, Washington 227. Caramanos Z, Posner G, Tomaioulo F, MacDonald D, Evans AC, Petrides M (1996) Quantitative analysis of the human inferior frontal operculum Proc 26th Annual Symposium, Society for Neuroscience, Washington 228. Fiset P, Paus T, Daloze T, Plourde G, Hofle N, Hajj-Ali N, Evans AC (1996) Effect of propofol- induced anesthesia on regional cerebral blood flow: A PET study Proc 26th Annual Symposium, Society for Neuroscience, Washington 229. Zatorre RJ, Mondor TA, Evans AC (1996) Functional activation of right parietal and frontal regions during auditory attention to space and frequency Proc 26th Annual Symposium, Society for Neuroscience, Washington 230. Westbury C, Zatorre RJ, Evans AC, Klein D (1996) The planum temporale: A re-assessment of its boundaries, area and volume using 3D in-vivo morphometric techniques Proc 26th Annual Symposium, Society for Neuroscience, Washington 231. Johnsrude I, Zatorre RJ, Worsley K, Klein D, Evans AC (1996) Hemispheric asymmetries in auditory regional CBF changes: Evidence from PET studies using different types of sounds Annual Meeting of ther McDonnell-Pew Program in Cognitive Neuroscience 232. Westbury C, Zatorre RJ, Evans AC (1996) Language lateralization and 3D in-vivo morphometry of the planum temporale

92 92 Annual Meeting of the McDonnell-Pew Program in Cognitive Neuroscience 233. Sled JG, Evans AC, Pike GB (1997) Standing-wave and RF penetration artifacts caused by elliptic geometry: an electrodynamic analysis of MRI Annual Meeeting, International Society for Magnetic Resonance in Medicine, ISMRM’97 234. Rousset OG, Ma Y, Evans AC (1997) Comparison of ROI-based versus pixel-based partial volume correction techniques BrainPET’97 235. Fiset P, Paus T, Daloze T, Plourde G, Hofle N, Hajj-Ali N, Evans AC (1997) Effect of propofol anesthesia on regional cerebral blood flow: A PET study Annual Meeting, Association of Quebec Anethesiologists 236. Sled JG, Evans AC, Pike GB (1997) Standing-wave and RF Penetration Artifacts Caused by Elliptic Geometry: An Electrodynamic Analysis of MRI, p. 1512 5th International Society of Magnetic Resonance in Medicine meeting 237. Kwan RKS, Evans AC, Pike GB (1997) MRI Simulation-Based Evaluation of Image Processing and Classification Methods, p. 2023 5th International Society of Magnetic Resonance in Medicine meeting 238. Johnsrude I, Paus T, Zatorre RJ, Perry DW, Ward GP, Evans AC (1997) The location of auditory activation foci relative to Heschl’s gyrus, #177 3rd International conference on Functional Mapping of the Human Brain 239. Wolforth M, Paus T, Evans AC (1997) Registration of transcranial magnetic stimulation (TMS) with positron emission tomography (PET) and magnetic resonance (MR) images, #? 3rd International conference on Functional Mapping of the Human Brain 240. Baare WFC, Collins DL, Kabani NJ,, MacDonald D, Liu C, Petrides M, Kahn RS, Evans AC (1997) Automated and manual identification of frontal lobe gyral cortex: A statistical probabilistic anantomical analysis, #348 3rd International conference on Functional Mapping of the Human Brain 241. Evans AC, Collins DL, Holmes CJ, Kabani NJ, Paus T, MacDonald D, Zijdenbos AP, Toga AW, Fox PT, Lancaster JL, Mazziotta JC (1997) A 3D probabilistic atlas of normal human neuroanatomy,#349 3rd International conference on Functional Mapping of the Human Brain 242. Caramanos Z, Venugopal R, Collins DL, MacDonald D, Evans AC, Petrides M (1997) Human brain sulcal anatomy: An MRI-based study,#350 3rd International conference on Functional Mapping of the Human Brain 243. Lee JW, Andermann FA, Dubeau F, Evans AC, Reutens DC (1997) Topographical mapping of temporal lobe projections in the corpus callosum, #351 3rd International conference on Functional Mapping of the Human Brain 244. Hoge RD, Crelier GR, Vafaee M, Meyer E, Marrett S, Evans AC, Pike GB (1997) Frequency- Dependent Changes in Oxidative Metabolism in Human Striate Cortex: Implications for BOLD fMRI,#363 3rd International conference on Functional Mapping of the Human Brain 245. Zijdenbos AP and Evans AC (1997) Stereotaxic mapping in automatic quantification of neuropathology: Application to multiple sclerosis,#396 3rd International conference on Functional Mapping of the Human Brain 246. Sled JG, Zijdenbos JG, Collins DL, Evans AC (1997) The impact of intensity non-uniformity on automated anatomical analysis of 3D MRI images,#399 3rd International conference on Functional Mapping of the Human Brain 247. Holmes CJ, Payne B, Thompson PM, MacDonald D, Evans AC, Toga AW (1997) Extruded parametric tetrahedral models for automated subnuclear surface extraction,#406 3rd International conference on Functional Mapping of the Human Brain 248. MacDonald D, Venugopal R, Caramanos Z, Petrides M, Avis D, Evans AC (1997) A surface- based 2-D sulcal atlas,#414 3rd International conference on Functional Mapping of the Human Brain 249. Thompson PM, MacDonald D, Sega MS, Holmes CJ, Evans AC, Toga AW (1997) Quantifying and correcting for variable cortical morphology in functional imaging using a deformable probabilistic brain atlas,#423

93 93 3rd International conference on Functional Mapping of the Human Brain 250. Cocosco CA, Kollokian V, Kwan RKS, Evans AC (1997) BRAINWEB: Online interface to a 3D MRI simulated brain database,#414 3rd International conference on Functional Mapping of the Human Brain 251. Kwan RKS, Evans AC, Pike GB (1997) fMRI Simulation for Quantitative Evaluation of Analysis Methods,#449 3rd International conference on Functional Mapping of the Human Brain 252. Poline JB, Worsley KJ, Evans AC, Friston KJ (1997) Issues in the use of two multivariate analyses for fMRI data,#472 3rd International conference on Functional Mapping of the Human Brain 253. Collins DL, Holmes CJ, Evans AC (1997) High resolution digital phantom of the huma brain,#510 3rd International conference on Functional Mapping of the Human Brain 254. Cao J, Worsley KJ, Liu C, Collins DL, Evans AC (1997) New statistical results for the detection of brain structural and functional change using random field theory,#512 3rd International conference on Functional Mapping of the Human Brain 255. Kabani NJ, MacDonald D, Gopnik M, Evans AC (1997) Cortical atrophy in familial language impairment assessed by automated tissue classification in stereotaxic space,#572 3rd International conference on Functional Mapping of the Human Brain 256. Beauregard M, Chertkow H, Whitehead V, Gold D, Evans A (1997) Functional mapping of implicit memory: a 3-D positron emission tomography study Proc 27th Annual Symposium, Society for Neuroscience, New Orleans: 87.6 37 257. Kabani N, Collins DL, Evans A (1997) Hemispheric differences in gray matter volume of adult human brain Proc 27th Annual Symposium, Society for Neuroscience, New Orleans: 89.6 38 258. Bermudez P, Zatorre RJ, Evans AC (1997) Human corpus callosum measures from 3-D MRI: morphometry, sex differences, and probability maps Proc 27th Annual Symposium, Society for Neuroscience, New Orleans 89.4 38 259. Koski L, Paus T, Hofle N, Petrides M, Evans AC (1997) Increased blood flow in basal ganglia, but not frontal cortex, when using spatial cues Proc 27th Annual Symposium, Society for Neuroscience, New Orleans: 181.11 81 260. Fiset P, Bonhomme V, Meuret P, Paus T, Plourde G, Backman S, Bushnell C, Evans AC (1997) Effects of propofol on regional cerebral blood flow during vibrotactile stimulation in man: a positron emission tomograpy study Proc 27th Annual Symposium, Society for Neuroscience, New Orleans: 398.14 178 261. Vafaee M, Meyer E, Marrett S, Paus T, Evans AC, Gjedde A (1997) Cerebral blood flow and cerebral metabolic rate of oxygen respond differently to the rate of visual stimulation Proc 27th Annual Symposium, Society for Neuroscience, New Orleans: 405.14 181 262. Klein D, Milner B, Zatorre RJ, Johnsrude I, Olivier AO, Petrides M, Taylor L, Meyer E, Evans AC (1997) CBF changes during word-generating in pre-surgical seizure patients Proc 27th Annual Symposium, Society for Neuroscience, New Orleans: 416.7 187 263. Paus T, Leonard G, Wolforth M, Visca R, Comeau R, Hoge B, Pike B, Peters T, Thompson CJ, Evans AC (1997) Cortico-cerebellar connectivity revealed by transcranial magnetic stimulation of the human motor cortex during positron emission tomography Proc 27th Annual Symposium, Society for Neuroscience, New Orleans: 503.10 226 264. Penhune VB, Zatorre RJ, Feindel W, Collins DL, Evans AC (1997) Effect of auditory cortex excision on perception and reproduction of temporal sequences Proc 27th Annual Symposium, Society for Neuroscience, New Orleans: 616.12 278 265. Dade LA, Zatorre RJ, Jones-Gotman M, Evans AC (1997) PET activation during face and odor working memory tasks Proc 27th Annual Symposium, Society for Neuroscience, New Orleans: 657.12 296 266. Crane J, Milner B, Evans AC (1997) Object-location memory as assessed with a multi-trial recall paradigm Proc 27th Annual Symposium, Society for Neuroscience, New Orleans: 819.1 372 267. Thompson PM, Mega MS, Blanton RE, Moussai J, Khan AA, Zohoori S, Mogy J, Aron J,

94 94 Goldkorn A, Holmes CJ, Small G, Cummings J, MacDonald D, Evans AC, Collins RC, Toga AW (1997) A detection system for mapping abnormal structure, anatomic variability and brain asymmetry in Alzheimer’s disease and aging with 3D deformable probabilistic brain atlases Proc 27th Annual Symposium, Society for Neuroscience, New Orleans: 844.11 383 268. Petitto LA, Zatorre RJ, Nikelski EJ, Guana K, Dostie D, Evans AC (1997) Cerebral organization for language in the absence of sound: a PET study of deaf signers processing signed languages Proc 27th Annual Symposium, Society for Neuroscience, New Orleans: 687.8 394 269. Dumoulin SO, Bittar RG, Kabani NJ, Baker Jr CL, Le Goualher G, Pike GB, Evans AC Quantification of the variability of human area V5/MT in relation to the sulcal pattern in the parieto- temporo-occipital cortex: A new anatomical landmark 4th International Conference on Functional Mapping of the Human Brain, Montreal, June 1998 270. Worsley KJ, Cao J, Paus T, Petrides M, Evans AC Detecting functional connectivity by thresholding correlation random fields 4th International Conference on Functional Mapping of the Human Brain, Montreal, June 1998 271. Shafie K, Worsley KJ, Wolforth M, Evans AC Rotation space: Detecting functional activation by searching over rotated and scaled filters 4th International Conference on Functional Mapping of the Human Brain, Montreal, June 1998 272. Vafaee MS, Meyer E, Evans AC, Gjedde A Oxidative metabolism in human brain varies in response to the rate of visual stimulation 4th International Conference on Functional Mapping of the Human Brain, Montreal, June 1998 273. Vafaee MS, Meyer E, Evans AC, Gjedde A Cerebral metabolic rate of oxygen (CMRO2) and Cerebral blood flow (CBF) in mitochondrial encephalomyopathy: A PET study 4th International Conference on Functional Mapping of the Human Brain, Montreal, June 1998 274. Liu J, Meyer E, Reutens D, Durcan L, Evans AC Bilateral motor activation during fast semi- complex finger movement in healthy subjects: A PET study 4th International Conference on Functional Mapping of the Human Brain, Montreal, June 1998 275. Liu J, Meyer E, Reutens D, Pike B, Durcan L, Evans AC Comparison of functional MRI to PET in detecting brain activation patterns induced by fast and slow finger movements 4th Interational Conference on Functional Mapping of the Human Brain, Montreal, June 1998 276. Zijdenbos AP, Jimenez A, Evans AC Pipelines: Large scale automatic analysis of 3D brain data sets 4th International Conference on Functional Mapping of the Human Brain, Montreal, June 1998 277. Bittar RG, Dumoulin SO, Ptito A, Pike GB, Evans AC Cortical areas activated by visual motion revealed by functional magnetic resonance imaging 4th International Conference on Functional Mapping of the Human Brain, Montreal, June 1998 278. Bittar RG, Ptito A, Faubert J, Pike GB, Evans AC Investigation of the anatomical basis of blindsight: An fMRI study of hemispherectomized subjects 4th International Conference on Functional Mapping of the Human Brain, Montreal, June 1998 279. Zatorre RJ, Bermudez P, Warrier CM, Evans AC Cerebral mechanisms associated with encoding and recognition of melodies 4th International Conference on Functional Mapping of the Human Brain, Montreal, June 1998 280. Doyon J, Owen AM, Dagher A, Chertkow H, Evans AC Abnormal basal ganglia outflow in Parkinson’s disease associated with motor sequence learning 4th International Conference on Functional Mapping of the Human Brain, Montreal, June 1998 281. Thompson P, Giedd JN, Blanton RE, Lindshield C, Badrtalei S, Woods RP, MacDonald D, Evans AC, Toga AW Growth patterns in the developing human brain detected using continuum-mechanical tensor maps and serial MRI 4th International Conference on Functional Mapping of the Human Brain, Montreal, June 1998 282. Warrier CM, Zatorre RJ, Peretz I, Besson M, Evans A PET study investigating the separation of lyrics and music in song 4th International Conference on Functional Mapping of the Human Brain, Montreal, June 1998 283. Kabani N, MacDonald DJ, Holmes CJ, Evans AC 3D Anatomical Atlas of the Human Brain 4th International Conference on Functional Mapping of the Human Brain, Montreal, June 1998 284. Jech R, Paus T, Ruzicka E, Zijdenbos AP, Krasensky J, Evans AC Estimation of conduction velocity in the visual pathway: a combined VEP and MRI study

95 95 4th International Conference on Functional Mapping of the Human Brain, Montreal, June 1998 285. Collins DL, Kabani NJ, Evans AC Automatic volume estimation of gross cerebral structures 4th International Conference on Functional Mapping of the Human Brain, Montreal, June 1998 286. St-Jean P, Sadikot AF, Clonda D, Kasrai R, Evans AC, Peters TM Interactive 3-Dimensional visualization tools for stereotactic atlas-based functional neurosurgery 4th International Conference on Functional Mapping of the Human Brain, Montreal, June 1998 287. Taylor J, Worsley KJ, Zijdenbos AP, Paus T, Evans AC Detecting anatomical changes using logistic regression of structure masks 4th International Conference on Functional Mapping of the Human Brain, Montreal, June 1998 288. Belin P, Zatorre RJ, Hoge R, Pike B, Evans AC Event-related fMRI of the auditory cortex 4th International Conference on Functional Mapping of the Human Brain, Montreal, June 1998 289. Neelin P, MacDonald D, Collins DL, Evans AC The MINC file format: From bytes to brains 4th International Conference on Functional Mapping of the Human Brain, Montreal, June 1998 290. Riahi F, Zijdenbos AP, Francis G, Evans A Correlation between cerebral lesion load and EDSS in relapsing remitting multiple sclerosis: results of the application of automatic 3D image analysis 4th International Conference on Functional Mapping of the Human Brain, Montreal, June 1998 291. MacDonald D, Avis D, Evans AC Automatic segmentation of cortical surfaces from MRI with partial-volume correction 4th International Conference on Functional Mapping of the Human Brain, Montreal, June 1998 292. Procyk E, Petrides M, Le Goualher G, Collins DL, Evans AC Sulcus extraction and automatic labelling(SEAL): II Generation of frontal sulci probabilistic 3D maps 4th International Conference on Functional Mapping of the Human Brain, Montreal, June 1998 293. Le Goualher G, Procyk E, Collins DL, Petrides M, Evans AC Sulcus extraction and automatic labelling(SEAL): I Method for mapping of sulcal neuroanatomy 4th International Conference on Functional Mapping of the Human Brain, Montreal, June 1998 294. Chiavaras M, Le Goualher G, Evans AC, Petrides M The human orbitofrontal cortex: sulcal patterns and probabilistic analysis 4th International Conference on Functional Mapping of the Human Brain, Montreal, June 1998 295. Petitto LA, Zatorre RJ, Nikelski EJ, Gauna K, Dostie D, Evans AC By hand or by tongue: Common cerebral blood flow activation during language processing in signed and spoken languages 4th International Conference on Functional Mapping of the Human Brain, Montreal, June 1998 296. Ma Y, Rousset OG, Evans AC Influence of image acquisition parameters on the topology of brain activation patterns with PET 4th International Conference on Functional Mapping of the Human Brain, Montreal, June 1998 297. Dagher A, Bleicher C, Aston JAD, Worsley KJ, Ma Y, Evans AC Measuring neurotransmitter release with positron emission tomography 4th International Conference on Functional Mapping of the Human Brain, Montreal, June 1998 298. Zijdenbos AP, Giedd JN, Blumenthal JD, Paus T, Rapoport JL, Evans AC Automatic quantitative analysis of 3D brain data sets: Application to a pediatric population 4th International Conference on Functional Mapping of the Human Brain, Montreal, June 1998 299. Valdes P, Pictea T, Trujillo N, Bosch J, Aubert E, Riera J, Biscay R, Carbonell F, Barroso E, Fernandez A, Evans A Constraining EEG-MEG source imaging with statistical neuroanatomy 4th International Conference on Functional Mapping of the Human Brain, Montreal, June 1998 300. Bohbot VD, Petrides M, Evans AC The collateral sulcus as landmark for the parahippocampal cortex 4th International Conference on Functional Mapping of the Human Brain, Montreal, June 1998 301. Collins DL, Zijdenbos AP, Evans AC Improved automatic gross cerebral structure segmentation 4th International Conference on Functional Mapping of the Human Brain, Montreal, June 1998 302. O’Driscoll GA, Benkelfat C, Florencio PS, Wolff AL, Grivell J, Lal S, Joober R, Evans AC Functional relevance of superior parietal activation during smooth pursuit 4th International Conference on Functional Mapping of the Human Brain, Montreal, June 1998 303. Bleicher C, Cumming P, Clarke P, Evans AC, Dagher A (1998) Quantitative PET studies of dopamine D1 receptors in the basal ganglia using 11C-SCH23390: Comparison of non-smoking volunteers and chronic cigarette smokers Proc 28th Annual Symposium, Society for Neuroscience, Los Angeles

96 96 304. O’Driscoll GA, Benkelfat C, Wolff AL, Baker CL, Lal S, Evans AC (1998) Motion perception thresholds and neural activity in area MT in humans Proc 28th Annual Symposium, Society for Neuroscience, Los Angeles 305. Blood AJ, Zatorre RJ, Bermudez P, Evans AC (1998) PET study of CBF responses to musical dissonance: Neural correlates of emotional responses to music Proc 28th Annual Symposium, Society for Neuroscience, Los Angeles 306. Collins DL, Paus T, Zijdenbos AP, Worsley K, Blumenthal J, Giedd J, Rapoport J, Evans AC (1998) Age related changes in the size of the human brain and its major sub-divisions: An MRI study of children and adolescents Proc 28th Annual Symposium, Society for Neuroscience, Los Angeles 307. Paus T, Zijdenbos AP, Worsley K, Collins DL, Blumenthal J, Giedd J, Rapoport J, Evans AC (1998) Age-related changes in white matter density along major fiber pathways: An MRI study of children and adolescents Proc 28th Annual Symposium, Society for Neuroscience, Los Angeles 308. Barnes GR, Hess RF, Petre V, Dumoulin SO, Hoge R, Evans AC (1999) Functional MRI responses to sinusoidal grating stimuli in strabismic amblyopes ARVO Meeting 309. Le Goualher G, Argenti A-M, Evans AC (1999) Study of the genetic encoding of the central sulcus shape using principal component analysis 5th Internat Conference on Functional Mapping of the Human Brain, Duesseldorf, June 1999 310. Aston JAD, Worsley KJ, Bleicher C, Ma Y, Gunn RN, Evans AC, Dagher A (1999) Statistical methods for measuring neurotransmitter release with Positron Emission Tomography 5th Internat Conference on Functional Mapping of the Human Brain, Duesseldorf, June 1999 311. Worsley KJ, Andermann M, Koulis T, MacDonald D, Evans AC (1999) Detecting changes in non-stationary images via statistical flattening 5th Internat Conference on Functional Mapping of the Human Brain, Duesseldorf, June 1999 312. Ma L, Worsley KJ, Evans AC (1999) Variability of spatial location of activation in fMRI and PET CBF images 5th Internat Conference on Functional Mapping of the Human Brain, Duesseldorf, June 1999 313. Dumoulin SO, Barnes GR, Baker CL, Evans AC (1999) Assessing random stimulus sequences for event-related fMRI 5th Internat Conference on Functional Mapping of the Human Brain, Duesseldorf, June 1999 314. Doyon J, Lavoie K, Penhune V, Collins DL, Schmahmann JD, Evans AC, Petrides M (1999) 3D probabilistic mapping of the human cerebellum from MRI scans in stereotaxic space 5th Internatl Conference on Functional Mapping of the Human Brain, Duesseldorf, June 1999 315. Penhune V, Petrides M, Lavoie K, Collins DL, Evans AC, Doyon J (1999) Volumetric measurements of the human cerebellum from MRI scans 5th Internat Conference on Functional Mapping of the Human Brain, Duesseldorf, June 1999 316. Kappos L, Comi G, Oger J, Panitch H, Agoropoulou C, Karlsson G, Murphy D, Evans A (1999) Double-blind, placebo-control, multicentre study evaluating safety, tolerability and effect of the altered peptide ligand MSP771 on MRI activity in relapsing-remitting multiple sclerosis ECTRIMS/ACTRIMS Meeting, Basel, September 1999 317. Lindsey JW, Stark SR, Oger JJ, Lublin F, Antel J, Sanielivici M, Bourgouin P, Evans AC, Crowe P, Murphy D (1999) Double-blind, randomized, placebo-control, parallel-group evaluation of the safety and effect on immunological parameters of the altered peptide ligand MSP771 in patients with MS ECTRIMS/ACTRIMS Meeting, Basel, September 1999 318. Reilhac A, Thiel A, Frouin V, Collins DL, Rousset OG, Evans AC (2001) Automated partial volume correction: Simulation-based assessment of errors BrainPET 2001, Taiwan 319. Thiel A, Reilhac A, Rousset OG, Collins DL, Evans AC (2001) Automated partial volume correction: Application to large numbers of PET data sets BrainPET 2001, Taiwan 320. Cocosco CA and Evans AC (2001) Java Internet Viewer: A WWW tool for remote 3D medical image data visualization and comparison

97 97 MICCAI 2001 321. Lerch J, Pruessner J, Evans AC, Zijdenbos AP, Teipel SJ, Buerger K, Hampel H (2002) Changes in cortical integrity in Alzheimer’s disease 18th Alzheimer’s Disease International Conference, Stockholm

98 98 Nomination of Karl J. Friston for the inaugural OHBM Glass Brain Award

Dear OHBM Council,

We – a group of 20 international neuroimaging scientists – enthusiastically and collectively nominate Professor Karl J. Friston as an outstanding candidate for the inaugural Glass Brain Award. We believe there is no other contemporary scientist who fulfils the criteria of the Glass Brain Award – extraordinary lifetime accomplishments in the field of human brain mapping and the promise of future major contributions to the field – as impressively as Karl Friston.

Friston is not only a highly reputed neuroimaging scientist with seminal contributions to many areas of cognitive neuroscience as well as psychiatry, but even more importantly he has contributed founding principles to the field of human brain mapping through his groundbreaking work in statistics, computational modelling and theoretical neurobiology. Crucially, whilst his fundamental work derives from the brain mapping community, his contributions and reputation extend well beyond those boundaries, establishing contributions to computational biology, stochastic mathematics, statistical inference and complex systems theory. In brief, Friston has produced an oeuvre of immense breadth and depth, which has been exerting a fundamental impact on neuroimaging and its related disciplines over more than two decades. It is remarkable that despite his contributions and seniority in the field, his creativity and productivity show no sign of diminishing, and he continues to make a dynamic, energetic and evergreen contribution to the intellectual and social fabric of the community.

In the following, we expand on three of his seminal contributions from different periods of his work:

1. Friston's work in the 1990's provided a cogent and extensive framework for inference on structural and functional images, named “statistical parametric mapping“ (SPM). These methodological innovations provided a systematic foundation for the nascent field of neuroimaging and have been greatly shaping its development until today. Many of the associated papers are citation classics, remain in constant use and continue to attract hundreds of citations each year. One example of his pioneering contributions was his work on Gaussian Random Field Theory (together with Keith Worsley), which provided a principled approach to family-wise error control for topological inference of neuroimaging data. Other significant contributions concerned image registration, normalization, segmentation and morphometry: Collectively these innovations provided a comprehensive framework - released into the public domain through the open source software package SPM - for the analysis of structural and functional imaging data. This work in turn underpinned the massive acceleration in the use of imaging technology to quantify the structural and functional principles of human brain organization.

2. Towards the end of this period, Friston’s intellectual contributions moved from the focus on functional specialization provided by SPM towards a complimentary framework for functional integration. In 2003, Friston published the foundation paper on Dynamic Causal Modelling (DCM), a generic method for inferring effective connectivity (and other physiological processes) from functional MRI data. This development rested on integrating two principled but previously distinct theories, i.e., dynamic systems theory and (variational) Bayesian inference. DCM has since been

99 generalized to other data modalities (e.g., EEG/MEG data and invasive recordings) and to incorporate stochastic and nonlinear models. Beyond its widespread application to experimental questions, DCM has elicited an important conceptual shift in neuroimaging, highlighting the importance of model comparison and validation studies.

3. Friston has more recently elucidated a cogent and ambitious unified theory of brain function, the “Free Energy Principle”. This approach integrates decades of research from the machine learning community on deep hierarchical learning with neuroimaging and psychological research on predictive coding. However, as with Friston’s other work, he has extended well beyond prior research, providing a principled foundation for the notion that the brain acts as a predictive device which maintains and updates a generative model of its sensory inputs in order to avoid surprise and thus maximise our chances for survival. A critical contribution here is the idea of “free energy” - an approximation to surprise - whose minimisation is postulated to underlie all neuronal processes, from the dendritic tree to the systems level. This is an exciting endeavour that is also engaging many researchers outside our discipline, including philosophers and theoretical physicists, and offering a unique means to understand the basic mechanisms that guide the functional organization of the human brain. Moreover, the free energy principle is already showing considerable impact in the clinical domain, guiding models of psychiatric symptoms and informing the design of innovative neuroimaging experiments. Friston’s own exploration of the clinical value of these models, in fields as diverse as psychosis, depression and Parkinson's disease, is extraordinarily influential and informative.

Friston’s work is recognised at the very highest levels of scientific endeavour. For his contributions to neuroscience, he was made a Fellow of the Royal Society in 2006 and of the Society of Biology in 2012. He has received numerous awards, including the inaugural Wiley Young Investigator Award in Human Brain Mapping (1996), the Golden Brain Award (2003), and the prestigious Weldon Memorial Prize (2013) by Oxford University for the “most noteworthy contribution to the development of mathematical or statistical methods applied to problems in Biology” in the past ten years. With more than 600 peer-reviewed articles, 77’000 citations and an h-index of 140 (Web of Science), he is a prolific and extraordinarily cited author of papers, as well as two core textbooks for the field.

In addition to these key intellectual and methodological contributions to neuroimaging science, Friston brings unique personal attributes to the field and has been supporting OHBM and neuroimaging journals in various functions. For example, he was Chair of the Council of OHBM (2000) and Editor-in-Chief of NeuroImage, Associate Editor of Human Brain Mapping and Senior Editor of PLoS Computational Biology. Those of us with editorial experience in the field can attest that Friston is one of the most engaged, helpful and constructive reviewers in the field. He has written a number of lively commentaries and contributed to some of the most important debates in the field, activities which ensure our field remains on its toes and keeps the intellectual standards to their highest possible. He set a precedent for the field by releasing all his software as well as key datasets into the public domain.

Furthermore, Friston has made great contributions to the field by training and mentoring an extraordinary number of junior neuroscientists, including nearly 30 PhD students and many more postdocs. Indeed, numerous of the field’s brightest and most accomplished neuroscientists started their careers under his supervision. As Scientific Director of the Functional Imaging Laboratory in

100 London, Friston helped create its unique scientific and educational atmosphere and provides an outstanding role model of an enabling senior colleague and mentor for young scientists. Finally, those of us fortunate to work directly with Friston know him as a kind, thoughtful, creative and wonderfully humoured colleague. He is incredibly generous with his time and provides advice and active help to anyone approaching him, as can be witnessed in everyday’s interactions and publicly on the SPM Mailing List.

In summary, Friston’s seminal contributions have enabled many of the tremendous advances of neuroimaging over the past two decades. While the field includes many brilliant and talented scientists, the impact his groundbreaking and ongoing work continues to have on neuroimaging is unmatched. We believe there is no more appropriate and deserving recipient of the inaugural Glass Brain Award than Karl Friston and hope that our joint nomination will find your approval.

Michael Breakspear, Queensland Institute of Medical Research, Australia Christian Büchel, University of Hamburg, Germany Gustavo Deco, Pompeu Fabra University, Spain Ray Dolan, Wellcome Trust Centre for Neuroimaging, London, UK Alan Evans, Montreal Neurological Institute, Canada Paul Fletcher, University of Cambridge, UK Chris Frith, Aarhus University, Denmark John Dylan Haynes, Humboldt University Berlin, Germany Barry Horwitz, National Institute of Health, USA Viktor Jirsa, CNRS, Aix-Marseille University, France Andreas Meyer-Lindenberg, University of Mannheim, Germany Anthony Randal McIntosh, University of Toronto, Canada John O’Doherty, California Institute of Technology, USA Cathy Price, Wellcome Trust Centre for Neuroimaging, London, UK Olaf Sporns, University of Indiana, USA Peter Robinson, University of Sydney, Australia Klaas Enno Stephan, University of Zurich & ETH Zurich, Switzerland Leslie Ungerleider, National Institute of Health, USA Arno Villringer, Max Planck Institute Leipzig, Germany Giulio Tononi, University of Wisconsin, USA

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Curriculum Vitae

Karl John Friston FRS

Personal Details

Born July 12th 1959 York UK GMC Registration No. (UK) 2893040 Married with three children NI No. (UK) WE 461973 A

Current appointments

2001 Scientific Director; Wellcome Trust Centre for Neuroimaging

1999 Wellcome Principal Research Fellow, Institute of Neurology, UK Honorary Consultant: The National Hospital for Neurology and Neurosurgery, Queen Square London, UK

1998 Professor: Institute of Neurology, University College London, UK

Education and Qualifications

1980 BA Gonville and Caius College, Cambridge UK (Exhibitioner) Medical Sciences Tripos (1b Physics and 1b Psychology) (Secretary: Cambridge University Medical Society)

1983 MBBS King's College Medical School London University, UK

1985 MA Cambridge University, UK

1988 MRCPsych

Professional History

Academic and Clinical

1984 - 1985 Pre-registration: (Surgery) Bromley Hospital and (Medicine) Farnborough Hospitals, UK

1985 - 1988 Post-registration: Rotational Training Scheme in Psychiatry Oxford University Department of Psychiatry, UK

1988 - 1991 Honorary Senior Registrar Department of Psychiatry Charing Cross

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And Westminster Medical School, UK

1991 - 1994 Honorary Senior Registrar Royal Post Graduate Medical School, UK

1991 - 1992 Honorary Lecturer Royal Post Graduate Medical School, UK

1994 - 1997 Senior Lecturer Wellcome Department of Cognitive Neurology Institute of Neurology, UK

Honorary Senior Lecturer University Department of Psychiatry Royal Free Hospital School of Medicine, UK

1997 - 1998 Reader, Institute of Neurology University College London, UK

Research

1987 - 1988 Wellcome Trust Research Fellow MRC Clinical Neuropharmacology Unit Oxford, UK

1988 - 1991 Wellcome Trust Research Fellow MRC Cyclotron Unit Hammersmith Hospital London, UK

1991 - 1992 MRC Clinical Scientist (Senior Grade) MRC Cyclotron Unit Hammersmith Hospital London, UK

1992 - 1994 W.M. Keck Foundation Fellow in Theoretical Neurobiology The Neurosciences Institute La Jolla CA, USA

1994 - 1999 Wellcome Senior Research Fellow in Clinical Science Institute of Neurology, UK

Appointments

Professional Bodies (current)

Member of the Royal College of Psychiatrists Member of the Association of British Neurologists Fellow of the Academy of Medical Sciences (1999) Fellow of the Royal Society (2006) Fellow of the Society of Biology (2012)

Editorial Boards (current)

Editor-in-Chief - NeuroImage (Emeritus) Associate Editor - Neuroscience Letters

Board Member - Biological Psychiatry

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Board Member - NeuroInformatics Board Member - Current Medical Imaging Reviews Board Member -The Open Applied Informatics Journal Board Member - Cognitive Neurodynamics Board Member - Cognitive Processing

Editorial Appointments (past)

Deputy Editor - PLoS – Computational Biology (Neuroscience) Associate Editor - Human Brain Mapping Senior Editor - Cognitive Brain Research Associate Editor - International Journal of Neural Systems

Scientific Advisory and Review Boards (past 10 years)

Society for Cognitive Neuroscience (Organizing Committee) 1996 – 1999 MRC Advisory Board (UK) 1998 – 2004 MRC Bioinformatics and Career Development Panel 1998 – 2002 MRC College of Experts 2004 – Organization for Human Brain Mapping (Organizing Committee and Advisory Board) 1996 – 7, Chair 1999. International Consortium for Brain Mapping 1996 – 1998 BrainMap (Neuroscience Imaging and Informatics 1995 – 1998) Medical Image Understanding and Analysis (UK) 1998 – 1999 Fight for Sight (Registered Charity No. 263434 UK) 1996 – 1999 HFSP Review Committee for Research Grants (Brain Functions) 2000 – 2004 Volkswagen Foundation, Scientific review panel 1999 – 2005 Human Brain mapping (Wiley) YIA Committee 2000 – 2004 Society for Cognitive Neuroscience (YIA Committee) (Chair 2006) 1999 – 2009 Comite Scientique (SAB) of the Departement D’etudes cognitives; ENS Paris 200 7– Advisory Board of the Bernstein Center for Computational Neuroscience, Berlin 2007– present Sectional Committee (8); Royal Society 2007 – 2009 Medals and Awards Committee (B–Side); Royal Society 2008 – present Psychology Advisory Board, University of York 2012 – present Scientific Advisory Board, SBRI, Lyon 2012 – present

Prizes and Awards

Wiley Young Investigator Award in Human Brain Mapping 1996 Chaire Pharmacia-Upjohn Belgium 1998-1999 Golden Brain Award Minerva Foundation 2003 Medal, Collège de France (Lecture series) 2008 Honorary Doctorate (University of York) 2011 Weldon Memorial Prize and Medal 2013

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Grants

 Wellcome Senior Research Fellowship in Clinical Science (1994-1999) £353K (Ref: 040795). Supplement (supporting Dr. E Lumer) £84,507  Wellcome Trust (1999-2004) Program Grant (Principal Research Fellowship); £1M (Ref: 56750/CH/MB/Ic)  Wellcome Trust (1999-2004) Core Support Grant for Functional Imaging Laboratory £7M (Ref: 037830/Z/95/C/JRS/KM/JAT) (Co-applicant)  Wellcome Trust (Prize Studentship, Lucy Lee) (2000) £58K (Ref: 065995/Z/01/Z/KS/KD/fh)  Wellcome Trust Joint Infrastructure Grant. Magnetoencephalography (MEG) facility UCL (2001) £2.7M. Co-applicant (awarded with RSJ Frackowiak, C Price, R Turner, C Frith and R Dolan)  Wellcome Trust (International Research Fellowship James Kilner) (2003) £48K (Ref: 061548/C/00/Z)  Wellcome Trust Program Grant. Modelling functional brain architectures (2004-2009) £555K (Ref: 056750/Z/99/B)  Wellcome Trust Block Access Grant for Functional Neuroimaging (2004-2006) £1.8M (with R Dolan)  Wellcome Trust Imaging Neuroscience at the Functional Imaging Laboratory (2006) £6.74M (Ref: 079866/Z/06/Z) (with R Dolan)  Wellcome Trust Principal Research Fellowship. Functional architectures in the brain (2009- 2019) £2.48M (Ref: 088130/Z/09/Z)

Academic Supervision

Ph.D. Studentships (primary and secondary supervision)

Christian Büchel (clinical postdoctoral fellow) 1994-1999 Effective connectivity in health and disease

Stefan Kiebel (supervision whilst seconded from Jena Germany) 1999 -2001 The General Linear Model in Neuroimaging

John Ashburner 1999 -2000 Spatial Transformation of Image Processes

Dave Chawla (Wellcome Prize Studentship) 1996-1999 The computational neurobiology of functional integration in visual cortex

Bryan Strange (MB Ph.D. Program, UCL) 1998-2001 Functional Imaging of the Neuropharmacology of Episodic Memory

Lucy Lee 2001-2004 TMS Studies of functional integration in the Brain

Richard Lewis (Student PRN 19051718) 2002-2005

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Investigating human visual-auditory integration using fMRI

Barrie Roulston (UCL Student PRN 29027617) 2003-2006 Visual Illusions and the brain

Oliver Hulme (UCL, Student PRN 29000137) 2003-2006 Functional anatomy of visual Salience

Lee Harrison (part-time) 2002-2008 Statistical physics and inference in the brain

Velia Cardin (UCL Student PRN 039011668) 2004-2007 Form construction in the human brain

Marta Garrido (UCL) 2004-2008 Perceptual leaning and connectivity in the brain

Andre Marreiros (UCL) 2006-2010 Biophysical models of fMRI and EEG

Chun Chuan Chen 2006-2009 Dynamic models of non-linear coupling in the brain

Marieke ScholvincK (4 Year Wellcome PhD UCL, Student PRN 39061951) 2006-2009 Figure-ground perception without visual awareness

Hanneke den Ouden (4 Year Wellcome PhD UCL Student PRN 39056968) 2005-2008 Connectivity and cross modal integration in the brain

Justin Chumbley (CoMPLEX PhD, UCL Student PRN 39052317) 2006-2009 Statistical estimation in dynamic models

Outi Tuomainen (UCL Student PRN 59003128) 2006-2009 Auditory Processing in Specific Language Impairment (SLI) and dyslexia

Miriam Cornelia Klein (Secondary) Neuroscience, Physiology and Pharmacology Research Start: 1-OCT-09

Harriet Ruth Brown (Primary) Institute of Neurology Research Start: SEP-10

Maren Urner (Secondary) Institute of Neurology Research Start: SEP-10

Chen Song (Secondary) Institute of Neurology Research Start: SEP-10

Peter Smittenaar (Secondary) Institute of Neurology Research Start: SEP-11

Marcos Economides (Secondary)

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Institute of Neurology Research Start: OCT-11

Marco Filipe Pinto Leite (Secondary) Institute of Neurology Research Start: JAN-12

Stephanie Bowen (Secondary) Institute of Neurology Research Start: DEC-12

Teaching Activity

Internal

Organizer of the Institute of Neurology Short Course: ‘Statistical Parametric Mapping’ 1994-2006

Lecturer: MSc. Institute of Neurology UCL

Currently, I provide supervision for about 8 Post-Doctoral Fellows/Scientific Officers under my scientific direction. I provide scientific guidance to approximately 48 junior research fellows whose research is carried out within my unit. I also provide a weekly imaging methodology ‘Clinic’ for the Institute of Neurology/National Hospital for Neurology and Neurosurgery.

External

Guest Faculty at International Workshops and Conferences. E.g.:

fMRI Workshop - Soc. of Mag. Res. in Medicine USA 1993; 1994 fMRI Workshop - Soc. of Cognitive Neuroscience San Francisco USA 1995 fMRI Workshop - Human Brain Mapping Boston USA 1996 Functional Neuroimaging Course - Cold Spring Harbor USA 1993; 1995 BrainMap (Session Chair and Organizer) - San Antonio USA 1995 - 1998 Summer School in Cognitive Neuroscience - Dartmouth USA 1997 Autumn School in Cognitive Neuroscience - Oxford UK 1997 Soc. of Neuroscience Short course - 1997 EU Summer School in Advanced Neurocomputation - Trieste 2000 - 2004 SDV Sommerakademie [Summer Academy] - Ftan 2005 ESF-Sponsored School in Computational Neuroscience – Barcelona 2008

Enabling Activity

Internal

Scientific Director: Wellcome Trust Centre for Neuroimaging

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The centre comprises 8 Principal Investigators, 48 Research Fellows, 8 Scientific Officers, 4 Radiographers with administrative and secretarial support staff. Directing involves the inception and co-ordination of projects concerned with acquiring and characterising brain data. These projects range from to optimising experimental design in functional MRI to the bio-mathematics of functional integration in the brain. The personnel involved include physicists, software engineers, statisticians neuroscientists and clinicians.

External

My key enabling activity has been, with colleagues, to provide a framework for the design and analysis of functional brain mapping experiments. This framework is known as statistical parametric mapping (SPM) and has been implemented in software. SPM is an international standard for analysing functional brain-imaging data and implements things like psychophysiological interactions. In 1994 my group developed voxel-based morphometry. VBM is a widely used neuroanatomic technique with numerous clinical applications. In 2002, I developed dynamic causal modelling to measure functional architectures in the brain. These techniques are used in systems neuroscience and as diagnostic aids and clinical research tools. They have been used diversely, from diagnosing different dementias with SPECT scans to detecting subliminal neuroanatomic correlates of Turner’s syndrome with MRI. Notable, among clinical applications, are headache, genetic disorders and epilepsy.

Bio-sketch

Karl Friston is a neuroscientist and authority on brain imaging. He invented statistical parametric mapping: SPM is an international standard for analyzing imaging data and rests on the general linear model and random field theory (developed with Keith Worsley). In 1994, his group developed voxel- based morphometry. VBM detects differences in neuroanatomy and is used clinically and as a surrogate in genetic studies. These technical contributions were motivated by schizophrenia research and theoretical studies of value-learning (with Gerry Edelman). In 1995 this work was formulated as the disconnection hypothesis of schizophrenia (with Chris Frith). In 2003, he invented dynamic causal modelling (DCM), which is used to infer the architecture of distributed systems like the brain. Mathematical contributions include variational (generalized) filtering and dynamic expectation maximization (DEM) for Bayesian model inversion and time-series analysis. Friston currently works on models of functional integration in the human brain and the principles that underlie neuronal interactions. His main contribution to theoretical neurobiology is a free-energy principle for action and perception (active inference). Friston received the first Young Investigators Award in Human Brain Mapping (1996) and was elected a Fellow of the Academy of Medical Sciences (1999) in recognition of contributions to the bio-medical sciences. In 2000 he was President of the international Organization of Human Brain Mapping. In 2003 he was awarded the Minerva Golden Brain Award and was elected a Fellow of the Royal Society in 2006. In 2008 he received a Medal, Collège de France and an Honorary Doctorate from the University of York in 2011. He became of Fellow of the Society of Biology in 2012 and received the Weldon Memorial prize and Medal in 2013 for contributions to mathematical biology.

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Short version

Karl Friston is a theoretical neuroscientist and authority on brain imaging. He invented statistical parametric mapping (SPM), voxel-based morphometry (VBM) and dynamic causal modelling (DCM). These contributions were motivated by schizophrenia research and theoretical studies of value- learning – formulated as the disconnection hypothesis of schizophrenia. His main contribution to theoretical neurobiology is a free-energy principle for action and perception (active inference). Friston received the first Young Investigators Award in Human Brain Mapping (1996) and was elected a Fellow of the Academy of Medical Sciences (1999). In 2000 he was President of the international Organization of Human Brain Mapping. In 2003 he was awarded the Minerva Golden Brain Award and was elected a Fellow of the Royal Society in 2006. In 2008 he received a Medal, Collège de France and an Honorary Doctorate from the University of York in 2011. He became of Fellow of the Society of Biology in 2012 and received the Weldon Memorial prize and Medal in 2013 for contributions to mathematical biology.

Publications: Books

Human Brain Function. (1 Ed.) Eds Frackowiak RSJ Friston KJ et al. Academic Press USA 1997.

Human Brain Function. (2 Ed.) Eds Frackowiak RSJ Friston KJ et al Academic Press USA 2004.

Statistical Parametric Mapping. (1. Ed.) Eds Friston KJ et al Academic Press USA 2006

Principles of Brain Dynamics. Eds. Rabinovich MI, Karl J. Friston KJ and Varona P MIT press 2012

Refereed Articles

1. Pinotsis DA, Brunet N, Bastos A, Bosman CA, Litvak V, Fries P, Friston KJ. Contrast gain-control and horizontal interactions in V1: A DCM study. Neuroimage. 2014 Feb 1. pii: S1053-8119(14)00077-9. doi: 10.1016/j.neuroimage.2014.01.047. [Epub ahead of print] PubMed PMID: 24495812.

2. Ivanov I, Liu X, Clerkin S, Schulz K, Fan J, Friston K, London ED, Schwartz J, Newcorn JH. Methylphenidate and brain activity in a reward/conflict paradigm: Role of the insula in task performance. Eur Neuropsychopharmacol. 2014 Jan 18. pii: S0924-977X(14)00029-7. doi: 10.1016/j.euroneuro.2014.01.017. [Epub ahead of print] PubMed PMID: 24491951.

3. Ranlund S, Nottage J, Shaikh M, Dutt A, Constante M, Walshe M, Hall MH, Friston K, Murray R, Bramon E. Resting EEG in psychosis and at-risk populations - A possible endophenotype? Schizophr Res. 2014 Jan 30. pii: S0920-9964(13)00695-6. doi: 10.1016/j.schres.2013.12.017. [Epub ahead of print] PubMed PMID: 24486144.

4. Moran RJ, Symmonds M, Dolan RJ, Friston KJ. The Brain Ages Optimally to Model Its Environment: Evidence from Sensory Learning over the Adult Lifespan. PLoS Comput Biol. 2014 Jan;10(1):e1003422. doi:

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10.1371/journal.pcbi.1003422. Epub 2014 Jan 23. PubMed PMID: 24465195; PubMed Central PMCID: PMC3900375.

5. Xu J, Rees G, Yin X, Song C, Han Y, Ge H, Pang Z, Xu W, Tang Y, Friston K, Liu S. Spontaneous neuronal activity predicts intersubject variations in executive control of attention. Neuroscience. 2014 Jan 18. pii: S0306-4522(14)00032-3. doi: 10.1016/j.neuroscience.2014.01.020. [Epub ahead of print] PubMed PMID: 24447598.

6. Kumar S, Sedley W, Barnes GR, Teki S, Friston KJ, Griffiths TD. A brain basis for musical hallucinations. Cortex. 2013 Dec 17. pii: S0010-9452(13)00308-0. doi: 10.1016/j.cortex.2013.12.002. [Epub ahead of print] PubMed PMID: 24445167.

7. Gandolla M, Ferrante S, Molteni F, Guanziroli E, Frattini T, Martegani A, Ferrigno G, Friston K, Pedrocchi A, Ward NS. Re-thinking the role of motor cortex: Context-sensitive motor outputs? Neuroimage. 2014 Jan 16. pii: S1053-8119(14)00022-6. doi: 10.1016/j.neuroimage.2014.01.011. [Epub ahead of print] PubMed PMID: 24440530.

8. Roiser JP, Wigton R, Kilner JM, Mendez MA, Hon N, Friston KJ, Joyce EM. Dysconnectivity in the frontoparietal attention network in schizophrenia. Front Psychiatry. 2013 Dec 24;4:176. doi: 10.3389/fpsyt.2013.00176. eCollection 2013. PubMed PMID: 24399975; PubMed Central PMCID: PMC3871715.

9. Brown HR, Friston KJ. The functional anatomy of attention: a DCM study. Front Hum Neurosci. 2013 Dec 2;7:784. doi: 10.3389/fnhum.2013.00784. eCollection 2013. PubMed PMID: 24348359; PubMed Central PMCID: PMC3845206.

10. Friston KJ, Kahan J, Biswal B, Razi A. A DCM for resting state fMRI. Neuroimage. 2013 Dec 15. pii: S1053- 8119(13)01213-5. doi: 10.1016/j.neuroimage.2013.12.009. [Epub ahead of print] PubMed PMID: 24345387.

11. Pinotsis DA, Leite M, Friston KJ. On conductance-based neural field models. Front Comput Neurosci. 2013 Nov 12;7:158. doi: 10.3389/fncom.2013.00158. eCollection 2013. PubMed PMID: 24273508; PubMed Central PMCID: PMC3824089.

12. Lieder F, Stephan KE, Daunizeau J, Garrido MI, Friston KJ. A neurocomputational model of the mismatch negativity. PLoS Comput Biol. 2013 Nov;9(11):e1003288. doi: 10.1371/journal.pcbi.1003288. Epub 2013 Nov 7. Erratum in: PLoS Comput Biol. 2013 Dec;9(12). doi:10.1371/annotation/ca4c3cdf-9573-4a93-9542- 3a62cdbb8396. PubMed PMID: 24244118; PubMed Central PMCID: PMC3820518.

13. Park HJ, Friston K. Structural and functional brain networks: from connections to cognition. Science. 2013 Nov 1;342(6158):1238411. doi: 10.1126/science.1238411. Review. PubMed PMID: 24179229.

14. Furl N, Henson RN, Friston KJ, Calder AJ. Top-down control of visual responses to fear by the amygdala. J Neurosci. 2013 Oct 30;33(44):17435-43. doi: 10.1523/JNEUROSCI.2992-13.2013. PubMed PMID: 24174677.

15. Shipp S, Adams RA, Friston KJ. Reflections on agranular architecture: predictive coding in the motor cortex. Trends Neurosci. 2013 Dec;36(12):706-16. doi: 10.1016/j.tins.2013.09.004. Epub 2013 Oct 22. PubMed PMID: 24157198; PubMed Central PMCID: PMC3858810.

16. Devor A, Bandettini PA, Boas DA, Bower JM, Buxton RB, Cohen LB, Dale AM, Einevoll GT, Fox PT, Franceschini MA, Friston KJ, Fujimoto JG, Geyer MA, Greenberg JH, Halgren E, Hämäläinen MS, Helmchen F, Hyman BT, Jasanoff A, Jernigan TL, Judd LL, Kim SG, Kleinfeld D, Kopell NJ, Kutas M, Kwong KK, Larkum ME, Lo EH, Magistretti PJ, Mandeville JB, Masliah E, Mitra PP, Mobley WC, Moskowitz MA, Nimmerjahn A, Reynolds JH, Rosen BR, Salzberg BM, Schaffer CB, Silva GA, So PT, Spitzer NC, Tootell RB, Van Essen DC, Vanduffel W, Vinogradov SA, Wald LL, Wang LV, Weber B, Yodh AG. The challenge of connecting the dots in

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the B.R.A.I.N. Neuron. 2013 Oct 16;80(2):270-4. doi: 10.1016/j.neuron.2013.09.008. PubMed PMID: 24139032; PubMed Central PMCID: PMC3864648.

17. Schwartenbeck P, Fitzgerald T, Dolan RJ, Friston K. Exploration, novelty, surprise, and free energy minimization. Front Psychol. 2013 Oct 7;4:710. doi: 10.3389/fpsyg.2013.00710. eCollection 2013. PubMed PMID: 24109469; PubMed Central PMCID: PMC3791848.

18. Friston K, Schwartenbeck P, Fitzgerald T, Moutoussis M, Behrens T, Dolan RJ. The anatomy of choice: active inference and agency. Front Hum Neurosci. 2013 Sep 25;7:598. doi: 10.3389/fnhum.2013.00598. eCollection 2013. PubMed PMID: 24093015; PubMed Central PMCID: PMC3782702.

19. Bach DR, Friston KJ, Dolan RJ. An improved algorithm for model-based analysis of evoked skin conductance responses. Biol Psychol. 2013 Dec;94(3):490-7. doi: 10.1016/j.biopsycho.2013.09.010. Epub 2013 Sep 21. PubMed PMID: 24063955; PubMed Central PMCID: PMC3853620.

20. Muthukumaraswamy SD, Carhart-Harris RL, Moran RJ, Brookes MJ, Williams TM, Errtizoe D, Sessa B, Papadopoulos A, Bolstridge M, Singh KD, Feilding A, Friston KJ, Nutt DJ. Broadband cortical desynchronization underlies the human psychedelic state. J Neurosci. 2013 Sep 18;33(38):15171-83. doi: 10.1523/JNEUROSCI.2063-13.2013. PubMed PMID: 24048847.

21. López JD, Litvak V, Espinosa JJ, Friston K, Barnes GR. Algorithmic procedures for Bayesian MEG/EEG source reconstruction in SPM. Neuroimage. 2014 Jan 1;84:476-87. doi: 10.1016/j.neuroimage.2013.09.002. Epub 2013 Sep 13. PubMed PMID: 24041874.

22. Rigoux L, Stephan KE, Friston KJ, Daunizeau J. Bayesian model selection for group studies - revisited. Neuroimage. 2014 Jan 1;84:971-85. doi: 10.1016/j.neuroimage.2013.08.065. Epub 2013 Sep 7. PubMed PMID: 24018303.

23. Yu Y, FitzGerald TH, Friston KJ. Working memory and anticipatory set modulate midbrain and putamen activity. J Neurosci. 2013 Aug 28;33(35):14040-7. doi: 10.1523/JNEUROSCI.1176-13.2013. PubMed PMID: 23986240; PubMed Central PMCID: PMC3756752.

24. Sengupta B, Stemmler MB, Friston KJ. Information and efficiency in the nervous system--a synthesis. PLoS Comput Biol. 2013;9(7):e1003157. doi: 10.1371/journal.pcbi.1003157. Epub 2013 Jul 25. PubMed PMID: 23935475; PubMed Central PMCID: PMC3723496.

25. Edward Roberts R, Curran HV, Friston KJ, Morgan CJ. Abnormalities in white matter microstructure associated with chronic ketamine use. Neuropsychopharmacology. 2014 Jan;39(2):329-38. doi: 10.1038/npp.2013.195. Epub 2013 Aug 9. PubMed PMID: 23929545; PubMed Central PMCID: PMC3870785.

26. Freund P, Weiskopf N, Ashburner J, Wolf K, Sutter R, Altmann DR, Friston K, Thompson A, Curt A. MRI investigation of the sensorimotor cortex and the corticospinal tract after acute spinal cord injury: a prospective longitudinal study. Lancet Neurol. 2013 Sep;12(9):873-81. doi: 10.1016/S1474-4422(13)70146- 7. Epub 2013 Jul 2. Erratum in: Lancet Neurol. 2013 Sep;12(9):846. PubMed PMID: 23827394; PubMed Central PMCID: PMC3744750.

27. Friston K. Life as we know it. J R Soc Interface. 2013 Jul 3;10(86):20130475. doi: 10.1098/rsif.2013.0475. Print 2013 Sep 6. PubMed PMID: 23825119; PubMed Central PMCID: PMC3730701.

28. FitzGerald TH, Friston KJ, Dolan RJ. Characterising reward outcome signals in sensory cortex. Neuroimage. 2013 Dec;83:329-34. doi: 10.1016/j.neuroimage.2013.06.061. Epub 2013 Jun 27. PubMed PMID: 23811411; PubMed Central PMCID: PMC3899024.

29. Moran R, Pinotsis DA, Friston K. Neural masses and fields in dynamic causal modeling. Front Comput Neurosci. 2013 May 28;7:57. doi: 10.3389/fncom.2013.00057. eCollection 2013. PubMed PMID: 23755005; PubMed Central PMCID: PMC3664834.

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30. Adams RA, Stephan KE, Brown HR, Frith CD, Friston KJ. The computational anatomy of psychosis. Front Psychiatry. 2013 May 30;4:47. doi: 10.3389/fpsyt.2013.00047. eCollection 2013. PubMed PMID: 23750138; PubMed Central PMCID: PMC3667557.

31. Gu X, Hof PR, Friston KJ, Fan J. Anterior insular cortex and emotional awareness. J Comp Neurol. 2013 Oct 15;521(15):3371-88. doi: 10.1002/cne.23368. PubMed PMID: 23749500.

32. Brown H, Adams RA, Parees I, Edwards M, Friston K. Active inference, sensory attenuation and illusions. Cogn Process. 2013 Nov;14(4):411-27. doi: 10.1007/s10339-013-0571-3. Epub 2013 Jun 7. PubMed PMID: 23744445; PubMed Central PMCID: PMC3824582.

33. Kumar S, von Kriegstein K, Friston KJ, Griffiths TD. A dynamic system for the analysis of acoustic features and valence of aversive sounds in the human brain. Adv Exp Med Biol. 2013;787:463-72. doi: 10.1007/978- 1-4614-1590-9_51. PubMed PMID: 23716253.

34. Urner M, Sarri M, Grahn J, Manly T, Rees G, Friston K. The role of prestimulus activity in visual extinction. Neuropsychologia. 2013 Jul;51(8):1630-7. doi: 10.1016/j.neuropsychologia.2013.05.005. Epub 2013 May 13. PubMed PMID: 23680398; PubMed Central PMCID: PMC3702998.

35. Friston K. Active inference and free energy. Behav Brain Sci. 2013 Jun;36(3):212-3. doi: 10.1017/S0140525X12002142. Epub 2013 May 10. PubMed PMID: 23663424.

36. Moran RJ, Campo P, Symmonds M, Stephan KE, Dolan RJ, Friston KJ. Free energy, precision and learning: the role of cholinergic neuromodulation. J Neurosci. 2013 May 8;33(19):8227-36. doi: 10.1523/JNEUROSCI.4255-12.2013. PubMed PMID: 23658161.

37. Friston K. Sample size and the fallacies of classical inference. Neuroimage. 2013 Nov 1;81:503-4. doi: 10.1016/j.neuroimage.2013.02.057. Epub 2013 Apr 11. PubMed PMID: 23583356.

38. Price CJ, Ramsden S, Hope TM, Friston KJ, Seghier ML. Predicting IQ change from brain structure: a cross- validation study. Dev Cogn Neurosci. 2013 Jul;5:172-84. doi: 10.1016/j.dcn.2013.03.001. Epub 2013 Mar 15. PubMed PMID: 23567505; PubMed Central PMCID: PMC3682176.

39. Urner M, Schwarzkopf DS, Friston K, Rees G. Early visual learning induces long-lasting connectivity changes during rest in the human brain. Neuroimage. 2013 Aug 15;77:148-56. doi: 10.1016/j.neuroimage.2013.03.050. Epub 2013 Apr 1. PubMed PMID: 23558105; PubMed Central PMCID: PMC3682182.

40. Lieder F, Daunizeau J, Garrido MI, Friston KJ, Stephan KE. Modelling trial-by-trial changes in the mismatch negativity. PLoS Comput Biol. 2013;9(2):e1002911. doi: 10.1371/journal.pcbi.1002911. Epub 2013 Feb 21. PubMed PMID: 23436989; PubMed Central PMCID: PMC3578779.

41. Campo P, Garrido MI, Moran RJ, García-Morales I, Poch C, Toledano R, Gil-Nagel A, Dolan RJ, Friston KJ. Network reconfiguration and working memory impairment in mesial temporal lobe epilepsy. Neuroimage. 2013 May 15;72:48-54. doi: 10.1016/j.neuroimage.2013.01.036. Epub 2013 Jan 28. PubMed PMID: 23370058; PubMed Central PMCID: PMC3610031.

42. Daunizeau J, Lemieux L, Vaudano AE, Friston KJ, Stephan KE. An electrophysiological validation of stochastic DCM for fMRI. Front Comput Neurosci. 2013 Jan 18;6:103. doi: 10.3389/fncom.2012.00103. eCollection 2012. PubMed PMID: 23346055; PubMed Central PMCID: PMC3548242.

43. Vossel S, Mathys C, Daunizeau J, Bauer M, Driver J, Friston KJ, Stephan KE. Spatial Attention, Precision, and Bayesian Inference: A Study of Saccadic Response Speed. Cereb Cortex. 2013 Jan 14. [Epub ahead of print] PubMed PMID: 23322402.

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44. van Wijk BC, Litvak V, Friston KJ, Daffertshofer A. Nonlinear coupling between occipital and motor cortex during motor imagery: a dynamic causal modeling study. Neuroimage. 2013 May 1;71:104-13. doi: 10.1016/j.neuroimage.2012.12.076. Epub 2013 Jan 11. PubMed PMID: 23313570.

45. Kahan J, Mancini L, Urner M, Friston K, Hariz M, Holl E, White M, Ruge D, Jahanshahi M, Boertien T, Yousry T, Thornton JS, Limousin P, Zrinzo L, Foltynie T. Therapeutic subthalamic nucleus deep brain stimulation reverses cortico-thalamic coupling during voluntary movements in Parkinson's disease. PLoS One. 2012;7(12):e50270. doi: 10.1371/journal.pone.0050270. Epub 2012 Dec 26. PubMed PMID: 23300524; PubMed Central PMCID: PMC3530565.

46. Li B, Liu L, Friston KJ, Shen H, Wang L, Zeng LL, Hu D. A treatment-resistant default mode subnetwork in major depression. Biol Psychiatry. 2013 Jul 1;74(1):48-54. doi: 10.1016/j.biopsych.2012.11.007. Epub 2012 Dec 27. PubMed PMID: 23273724.

47. Friston K, Moran R, Seth AK. Analysing connectivity with Granger causality and dynamic causal modelling. Curr Opin Neurobiol. 2013 Apr;23(2):172-8. doi: 10.1016/j.conb.2012.11.010. Epub 2012 Dec 21. Review. PubMed PMID: 23265964.

48. Freund P, Schneider T, Nagy Z, Hutton C, Weiskopf N, Friston K, Wheeler-Kingshott CA, Thompson AJ. Degeneration of the injured cervical cord is associated with remote changes in corticospinal tract integrity and upper limb impairment. PLoS One. 2012;7(12):e51729. doi: 10.1371/journal.pone.0051729. Epub 2012 Dec 12. PubMed PMID: 23251612; PubMed Central PMCID: PMC3520920.

49. Seghier ML, Friston KJ. Network discovery with large DCMs. Neuroimage. 2013 Mar;68:181-91. doi: 10.1016/j.neuroimage.2012.12.005. Epub 2012 Dec 13. PubMed PMID: 23246991; PubMed Central PMCID: PMC3566585.

50. Barnes GR, Ridgway GR, Flandin G, Woolrich M, Friston K. Set-level threshold-free tests on the intrinsic volumes of SPMs. Neuroimage. 2013 Mar;68:133-40. doi: 10.1016/j.neuroimage.2012.11.046. Epub 2012 Dec 12. PubMed PMID: 23246858; PubMed Central PMCID: PMC3625125.

51. Friston KJ, Lawson R, Frith CD. On hyperpriors and hypopriors: comment on Pellicano and Burr. Trends Cogn Sci. 2013 Jan;17(1):1. doi: 10.1016/j.tics.2012.11.003. Epub 2012 Dec 5. PubMed PMID: 23218940.

52. Friston KJ. A Free Energy Principle for Biological Systems. Entropy (Basel). 2012 Nov;14(11):2100-2121. PubMed PMID: 23204829; PubMed Central PMCID: PMC3510653.

53. Bastos AM, Usrey WM, Adams RA, Mangun GR, Fries P, Friston KJ. Canonical microcircuits for predictive coding. Neuron. 2012 Nov 21;76(4):695-711. doi: 10.1016/j.neuron.2012.10.038. Review. PubMed PMID: 23177956; PubMed Central PMCID: PMC3777738.

54. Ivanov I, Liu X, Clerkin S, Schulz K, Friston K, Newcorn JH, Fan J. Effects of motivation on reward and attentional networks: an fMRI study. Brain Behav. 2012 Nov;2(6):741-53. doi: 10.1002/brb3.80. Epub 2012 Sep 23. PubMed PMID: 23170237; PubMed Central PMCID: PMC3500461.

55. Marreiros AC, Cagnan H, Moran RJ, Friston KJ, Brown P. Basal ganglia-cortical interactions in Parkinsonian patients. Neuroimage. 2012 Nov 13;66C:301-310. doi: 10.1016/j.neuroimage.2012.10.088. [Epub ahead of print] PubMed PMID: 23153964; PubMed Central PMCID: PMC3573233.

56. FitzGerald TH, Friston KJ, Dolan RJ. Action-specific value signals in reward-related regions of the human brain. J Neurosci. 2012 Nov 14;32(46):16417-23a. doi: 10.1523/JNEUROSCI.3254-12.2012. PubMed PMID: 23152624; PubMed Central PMCID: PMC3549268.

57. Friston K, Adams R, Montague R. What is value-accumulated reward or evidence? Front Neurorobot. 2012 Nov 2;6:11. doi: 10.3389/fnbot.2012.00011. eCollection 2012. PubMed PMID: 23133414; PubMed Central PMCID: PMC3487150.

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58. Adams RA, Shipp S, Friston KJ. Predictions not commands: active inference in the motor system. Brain Struct Funct. 2013 May;218(3):611-43. doi: 10.1007/s00429-012-0475-5. Epub 2012 Nov 6. Review. PubMed PMID: 23129312; PubMed Central PMCID: PMC3637647.

59. Pinotsis DA, Schwarzkopf DS, Litvak V, Rees G, Barnes G, Friston KJ. Dynamic causal modelling of lateral interactions in the visual cortex. Neuroimage. 2012 Nov 2;66C:563-576. doi: 10.1016/j.neuroimage.2012.10.078. [Epub ahead of print] PubMed PMID: 23128079; PubMed Central PMCID: PMC3547173.

60. Adams RA, Perrinet LU, Friston K. Smooth pursuit and visual occlusion: active inference and oculomotor control in schizophrenia. PLoS One. 2012;7(10):e47502. doi: 10.1371/journal.pone.0047502. Epub 2012 Oct 26. PubMed PMID: 23110076; PubMed Central PMCID: PMC3482214.

61. Bach DR, Friston KJ. Model-based analysis of skin conductance responses: Towards causal models in psychophysiology. Psychophysiology. 2013 Jan;50(1):15-22. doi: 10.1111/j.1469-8986.2012.01483.x. Epub 2012 Oct 24. Review. PubMed PMID: 23094650.

62. Pinotsis DA, Hansen E, Friston KJ, Jirsa VK. Anatomical connectivity and the resting state activity of large cortical networks. Neuroimage. 2013 Jan 15;65:127-38. doi: 10.1016/j.neuroimage.2012.10.016. Epub 2012 Oct 17. PubMed PMID: 23085498; PubMed Central PMCID: PMC3520011.

63. Kumar S, von Kriegstein K, Friston K, Griffiths TD. Features versus feelings: dissociable representations of the acoustic features and valence of aversive sounds. J Neurosci. 2012 Oct 10;32(41):14184-92. doi: 10.1523/JNEUROSCI.1759-12.2012. PubMed PMID: 23055488; PubMed Central PMCID: PMC3505833.

64. Friston K. Self-organisation, inference and cognition: comment on "Consciousness, crosstalk, and the mereological fallacy: an evolutionary perspective" by Rodrick Wallace. Phys Life Rev. 2012 Dec;9(4):456-7; discussion 458-9. doi: 10.1016/j.plrev.2012.09.005. Epub 2012 Sep 26. PubMed PMID: 23040972.

65. Litvak V, Jha A, Flandin G, Friston K. Convolution models for induced electromagnetic responses. Neuroimage. 2013 Jan 1;64:388-98. doi: 10.1016/j.neuroimage.2012.09.014. Epub 2012 Sep 14. PubMed PMID: 22982359; PubMed Central PMCID: PMC3518783.

66. Friston K. Predictive coding, precision and synchrony. Cogn Neurosci. 2012;3(3-4):238-9. doi: 10.1080/17588928.2012.691277. PubMed PMID: 24171746.

67. Schmidt A, Diaconescu AO, Kometer M, Friston KJ, Stephan KE, Vollenweider FX. Modeling ketamine effects on synaptic plasticity during the mismatch negativity. Cereb Cortex. 2013 Oct;23(10):2394-406. doi: 10.1093/cercor/bhs238. Epub 2012 Aug 8. PubMed PMID: 22875863; PubMed Central PMCID: PMC3767962.

68. Friston K, Samothrakis S, Montague R. Active inference and agency: optimal control without cost functions. Biol Cybern. 2012 Oct;106(8-9):523-41. Epub 2012 Aug 3. PubMed PMID: 22864468.

69. Vossel S, Weidner R, Driver J, Friston KJ, Fink GR. Deconstructing the architecture of dorsal and ventral attention systems with dynamic causal modeling. J Neurosci. 2012 Aug 1;32(31):10637-48. doi: 10.1523/JNEUROSCI.0414-12.2012. PubMed PMID: 22855813; PubMed Central PMCID: PMC3432566.

70. Litvak V, Eusebio A, Jha A, Oostenveld R, Barnes G, Foltynie T, Limousin P, Zrinzo L, Hariz MI, Friston K, Brown P. Movement-related changes in local and long-range synchronization in Parkinson's disease revealed by simultaneous magnetoencephalography and intracranial recordings. J Neurosci. 2012 Aug 1;32(31):10541-53. doi: 10.1523/JNEUROSCI.0767-12.2012. PubMed PMID: 22855804; PubMed Central PMCID: PMC3428626.

71. Friston K. Embodied inference and spatial cognition. Cogn Process. 2012 Aug;13 Suppl 1:S171-7. doi: 10.1007/s10339-012-0519-z. PubMed PMID: 22843089.

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72. Perception and self-organized instability. Friston K, Breakspear M, Deco G. Front Comput Neurosci. 2012;6:44. Epub 2012 Jul 6.

73. Dynamic causal modelling of precision and synaptic gain in visual perception - an EEG study. Brown HR, Friston KJ. Neuroimage. 2012 Jun 29;63(1):223-231

74. Task-Dependent Modulation of Effective Connectivity within the Default Mode Network. Li B, Wang X, Yao S, Hu D, Friston K. Front Psychol. 2012;3:206

75. Tracking Changes following Spinal Cord Injury: Insights from Neuroimaging. Freund P, Curt A, Friston K, Thompson A. Neuroscientist. 2012 Jun 22. [Epub ahead of print]

76. Imaging the interaction: Epileptic discharges, working memory, and behavior. Chaudhary UJ, Centeno M, Carmichael DW, Vollmar C, Rodionov R, Bonelli S, Stretton J, Pressler R, Eriksson SH, Sisodiya S, Friston K, Duncan JS, Lemieux L, Koepp M. Hum Brain Mapp. 2012 Jun 19. doi: 10.1002/hbm.22115. [Epub ahead of print]

77. Perceptions as hypotheses: saccades as experiments. Friston K, Adams RA, Perrinet L, Breakspear M. Front Psychol. 2012;3:151. Epub 2012 May 28.

78. A Bayesian account of 'hysteria' Edwards MJ, Adams RA, Brown H, Pareés I, Friston KJ.

79. Brain. 2012 May 28.

80. Waking and dreaming consciousness: neurobiological and functional considerations. Hobson JA, Friston KJ. Prog Neurobiol. 2012 Jul;98(1):82-98.

81. Connectivity changes underlying spectral EEG changes during propofol-induced loss of consciousness. Boly M, Moran R, Murphy M, Boveroux P, Bruno MA, Noirhomme Q, Ledoux D, Bonhomme V, Brichant JF, Tononi G, Laureys S, Friston K. J Neurosci. 2012 May 16;32(20):7082-90.

82. Free-energy minimization and the dark-room problem. Friston K, Thornton C, Clark A. Front Psychol. 2012;3:130.

83. Stochastic dynamic causal modelling of fMRI data: should we care about neural noise? Daunizeau J, Stephan KE, Friston KJ. Neuroimage. 2012 Aug 1;62(1):464-81.

84. Post-hoc selection of dynamic causal models. Rosa MJ, Friston K, Penny W. J Neurosci Methods. 2012 Jun 30;208(1):66-78.

85. Ten ironic rules for non-statistical reviewers. Friston K. Neuroimage. 2012 Jul 16;61(4):1300-10.

86. Axonal integrity predicts cortical reorganisation following cervical injury. Freund P, Wheeler-Kingshott CA, Nagy Z, Gorgoraptis N, Weiskopf N, Friston K, Thompson AJ, Hutton C. J Neurol Neurosurg Psychiatry. 2012 Jun;83(6):629-37.

87. Free-energy and illusions: the cornsweet effect. Brown H, Friston KJ. Front Psychol. 2012;3:43. Epub 2012 Feb 29.

88. Parental substance abuse and function of the motivation and behavioral inhibition systems in drug-naïve youth. Ivanov I, Liu X, Shulz K, Fan J, London E, Friston K, Halperin JM, Newcorn JH. Psychiatry Res. 2012 Feb 28;201(2):128-35.

89. Learning and generalization under ambiguity: an fMRI study. Chumbley JR, Flandin G, Bach DR, Daunizeau J, Fehr E, Dolan RJ, Friston KJ. PLoS Comput Biol. 2012 Jan;8(1):e1002346

90. Distributed processing; distributed functions? Fox PT, Friston KJ. Neuroimage. 2012 Jun;61(2):407-26.

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91. Dopamine, affordance and active inference. Friston KJ, Shiner T, FitzGerald T, Galea JM, Adams R, Brown H, Dolan RJ, Moran R, Stephan KE, Bestmann S. PLoS Comput Biol. 2012 Jan;8(1):e1002327

92. Free energy, value, and attractors. Friston K, Ao P. Comput Math Methods Med. 2012;2012:937860.

93. How doctors generate diagnostic hypotheses: a study of radiological diagnosis with functional magnetic resonance imaging. Melo M, Scarpin DJ, Amaro E Jr, Passos RB, Sato JR, Friston KJ, Price CJ. PLoS One. 2011;6(12):e28752

94. Prediction, perception and agency. Friston K. Int J Psychophysiol. 2012 Feb;83(2):248-52. Epub 2011 Dec 13..

95. Computational psychiatry. Montague PR, Dolan RJ, Friston KJ, Dayan P. Trends Cogn Sci. 2012 Jan;16(1):72- 80. Epub 2011 Dec 14. Erratum in: Trends Cogn Sci. 2012 May;16(5):306.

96. Model selection and gobbledygook: Friston K, Daunizeau J, Stephan KE. Neuroimage. 2011 Dec 1. [Epub ahead of print]

97. Optimizing experimental design for comparing models of brain function. Daunizeau J, Preuschoff K, Friston K, Stephan K. PLoS Comput Biol. 2011 Nov;7(11):e1002280.

98. What is optimal about motor control? Friston K. Neuron. 2011 Nov 3;72(3):488-98. doi: 10.1016/j.neuron.2011.10.018.

99. The influence of spontaneous activity on stimulus processing in primary visual cortex. Schölvinck ML, Friston KJ, Rees G. Neuroimage. 2012 Feb 1;59(3):2700-8.

100. The problem of low variance voxels in statistical parametric mapping; a new hat avoids a 'haircut'. Ridgway GR, Litvak V, Flandin G, Friston KJ, Penny WD. Neuroimage. 2012 Feb 1;59(3):2131-41.

101. The history of the future of the Bayesian brain. Friston K. Neuroimage. 2012 Aug 15;62(2):1230-3. Epub 2011 Oct 17.

102. Free energy and dendritic self-organization. Kiebel SJ, Friston KJ. Front Syst Neurosci. 2011;5:80.

103. Effective connectivity during processing of facial affect: evidence for multiple parallel pathways. Dima D, Stephan KE, Roiser JP, Friston KJ, Frangou S. J Neurosci. 2011 Oct 5;31(40):14378-85.

104. Active inference, attention, and motor preparation. Brown H, Friston K, Bestmann S. Front Psychol. 2011;2:218.

105. Dynamic causal modeling with neural fields. Pinotsis DA, Moran RJ, Friston KJ. Neuroimage. 2012 Jan 16;59(2):1261-74.

106. No evidence for a negative prediction error signal in peripheral indicators of sympathetic arousal. Bach DR, Friston KJ. Neuroimage. 2012 Jan 16;59(2):883-4.

107. Decoding episodic memory in ageing: a Bayesian analysis of activity patterns predicting memory. Morcom AM, Friston KJ. Neuroimage. 2012 Jan 16;59(2):1772-82

108. A Parametric Empirical Bayesian Framework for the EEG/MEG Inverse Problem: Generative Models for Multi-Subject and Multi-Modal Integration. Henson RN, Wakeman DG, Litvak V, Friston KJ. Front Hum Neurosci. 2011;5:76.

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109. The danger of systematic bias in group-level FMRI-lag-based causality estimation. Smith SM, Bandettini PA, Miller KL, Behrens TE, Friston KJ, David O, Liu T, Woolrich MW, Nichols TE. Neuroimage. 2012 Jan 16;59(2):1228-9.

110. Alterations in brain connectivity underlying beta oscillations in Parkinsonism. Moran RJ, Mallet N, Litvak V, Dolan RJ, Magill PJ, Friston KJ, Brown P. PLoS Comput Biol. 2011 Aug;7(8):e1002124

111. A dynamic causal model for evoked and induced responses. Chen CC, Kiebel SJ, Kilner JM, Ward NS, Stephan KE, Wang WJ, Friston KJ. Neuroimage. 2012 Jan 2;59(1):340-8.

112. Dynamic causal models and physiological inference: a validation study using isoflurane anaesthesia in rodents. Moran RJ, Jung F, Kumagai T, Endepols H, Graf R, Dolan RJ, Friston KJ, Stephan KE, Tittgemeyer M. PLoS One. 2011;6(8):e22790

113. Academic software applications for electromagnetic brain mapping using MEG and EEG. Baillet S, Friston K, Oostenveld R. Comput Intell Neurosci. 2011;2011:972050.

114. DCM for complex-valued data: cross-spectra, coherence and phase-delays. Friston KJ, Bastos A, Litvak V, Stephan KE, Fries P, Moran RJ. Neuroimage. 2012 Jan 2;59(1):439-55.

115. Remote effects of hippocampal sclerosis on effective connectivity during working memory encoding: a case of connectional diaschisis? Campo P, Garrido MI, Moran RJ, Maestú F, García-Morales I, Gil-Nagel A, del Pozo F, Dolan RJ, Friston KJ. Cereb Cortex. 2012 Jun;22(6):1225-36.

116. An in vivo assay of synaptic function mediating human cognition. Moran RJ, Symmonds M, Stephan KE, Friston KJ, Dolan RJ. Curr Biol. 2011 Aug 9;21(15):1320-5.

117. Slice-timing effects and their correction in functional MRI. Sladky R, Friston KJ, Tröstl J, Cunnington R, Moser E, Windischberger C. Neuroimage. 2011 Sep 15;58(2):588-94.

118. A bayesian foundation for individual learning under uncertainty. Mathys C, Daunizeau J, Friston KJ, Stephan KE. Front Hum Neurosci. 2011;5:39.

119. Freund P, Weiskopf N, Ward NS, Hutton C, Gall A, Ciccarelli O, Craggs M, Friston K, Thompson AJ. Disability, atrophy and cortical reorganization following spinal cord injury. Brain. 2011 Jun;134(Pt 6):1610-22. Epub 2011 May 17.

120. Boly M, Garrido MI, Gosseries O, Bruno MA, Boveroux P, Schnakers C, Massimini M, Litvak V, Laureys S, Friston K. Preserved feedforward but impaired top-down processes in the vegetative state. Science. 2011 May 13;332(6031):858-62.

121. Valdes-Sosa PA, Roebroeck A, Daunizeau J, Friston K. Effective connectivity: Influence, causality and biophysical modeling. Neuroimage. 2011 Apr 6. [Epub ahead of print]

122. Coste CP, Sadaghiani S, Friston KJ, Kleinschmidt A. Ongoing Brain Activity Fluctuations Directly Account for Intertrial and Indirectly for Intersubject Variability in Stroop Task Performance. Cereb Cortex. 2011 Apr 6. [Epub ahead of print]

123. Friston K, Penny W. Post hoc Bayesian model selection. Neuroimage. 2011 Jun 15;56(4):2089-99. Epub 2011 Mar 31.

124. Kumar S, Sedley W, Nourski KV, Kawasaki H, Oya H, Patterson RD, Howard MA, Friston KJ, Griffiths TD. Predictive Coding and Pitch Processing in the Auditory Cortex. J Cogn Neurosci. 2011 Mar 31. [Epub ahead of print]

117

125. Litvak V, Mattout J, Kiebel S, Phillips C, Henson R, Kilner J, Barnes G, Oostenveld R, Daunizeau J, Flandin G, Penny W, Friston K. EEG and MEG data analysis in SPM8. Comput Intell Neurosci. 2011;2011:852961. Epub 2011 Mar 6.

126. Friston KJ, Price CJ. Modules and brain mapping. Cogn Neuropsychol. 2011 Mar 15:1-10. [Epub ahead of print]

127. Barnes GR, Litvak V, Brookes MJ, Friston KJ. Controlling false positive rates in mass-multivariate tests for electromagnetic responses. Neuroimage. 2011 Jun 1;56(3):1072-81. Epub 2011 Mar 17.

128. Havlicek M, Friston KJ, Jan J, Brazdil M, Calhoun VD. Dynamic modeling of neuronal responses in fMRI using cubature Kalman filtering. Neuroimage. 2011 Jun 15;56(4):2109-28. Epub 2011 Mar 9.

129. Friston K, Mattout J, Kilner J. Action understanding and active inference. Biol Cybern. 2011 Feb;104(1- 2):137-60. Epub 2011 Feb 17.

130. Li B, Daunizeau J, Stephan KE, Penny W, Hu D, Friston K. Generalised filtering and stochastic DCM for fMRI. Neuroimage. 2011 Feb 17. [Epub ahead of print]

131. Diedrichsen J, Ridgway GR, Friston KJ, Wiestler T. Comparing the similarity and spatial structure of neural representations: a pattern-component model. Neuroimage. 2011 Apr 15;55(4):1665-78. Epub 2011 Jan 20.

132. Moran RJ, Stephan KE, Dolan RJ, Friston KJ. Consistent spectral predictors for dynamic causal models of steady-state responses. Neuroimage. 2011 Apr 15;55(4):1694-708. Epub 2011 Jan 13.

133. Ashburner J, Friston KJ. Diffeomorphic registration using geodesic shooting and Gauss-Newton optimisation. Neuroimage. 2011 Apr 1;55(3):954-67. Epub 2011 Jan 7.

134. Rosa MJ, Daunizeau J, Friston KJ. EEG-fMRI integration: a critical review of biophysical modeling and data analysis approaches. J Integr Neurosci. 2010 Dec;9(4):453-76.

135. Stephan KE, Friston KJ. Analyzing effective connectivity with fMRI. Wiley Interdiscip Rev Cogn Sci. 2010 Jun;1(3):446-459.

136. Friston KJ, Li B, Daunizeau J, Stephan KE. Network discovery with DCM. Neuroimage. 2011 Jun 1;56(3):1202-21. Epub 2010 Dec 21.

137. Daunizeau J, den Ouden HE, Pessiglione M, Kiebel SJ, Friston KJ, Stephan KE. Observing the observer (II): deciding when to decide. PLoS One. 2010 Dec 14;5(12):e15555.

138. Daunizeau J, den Ouden HE, Pessiglione M, Kiebel SJ, Stephan KE, Friston KJ. Observing the observer (I): meta-bayesian models of learning and decision-making. PLoS One. 2010 Dec 14;5(12):e15554.

139. Feldman H, Friston KJ. Attention, uncertainty, and free-energy. Front Hum Neurosci. 2010 Dec 2;4:215.

140. Litvak V, Jha A, Eusebio A, Oostenveld R, Foltynie T, Limousin P, Zrinzo L, Hariz MI, Friston K, Brown P. Resting oscillatory cortico-subthalamic connectivity in patients with Parkinson's disease. Brain. 2011 Feb;134(Pt 2):359-74. Epub 2010 Dec 8.

141. Pinotsis DA, Friston KJ. Neural fields, spectral responses and lateral connections. Neuroimage. 2011 Mar 1;55(1):39-48. Epub 2010 Dec 4.

142. Yoshida W, Seymour B, Friston KJ, Dolan RJ. Neural mechanisms of belief inference during cooperative games. J Neurosci. 2010 Aug 11;30(32):10744-51.

143. Sadaghiani S, Hesselmann G, Friston KJ, Kleinschmidt A. The relation of ongoing brain activity, evoked neural responses, and cognition. Front Syst Neurosci. 2010 Jun 23;4:20.

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144. Friston K. Is the free-energy principle neurocentric? Nat Rev Neurosci. 2010 Jul 14. [Epub ahead of print] No abstract available.

145. Cardin V, Friston KJ, Zeki S. Top-down modulations in the visual form pathway revealed with dynamic causal modeling. Cereb Cortex. 2011 Mar;21(3):550-62. Epub 2010 Jul 9.

146. Bach DR, Daunizeau J, Friston KJ, Dolan RJ. Dynamic causal modelling of anticipatory skin conductance responses. Biol Psychol. 2010 Sep;85(1):163-70. Epub 2010 Jun 25.

147. Yoshida W, Dziobek I, Kliemann D, Heekeren HR, Friston KJ, Dolan RJ. Cooperation and heterogeneity of the autistic mind. J Neurosci. 2010 Jun 30;30(26):8815-8.

148. Chen CC, Kilner JM, Friston KJ, Kiebel SJ, Jolly RK, Ward NS. Nonlinear coupling in the human motor system. J Neurosci. 2010 Jun 23;30(25):8393-9.

149. Chumbley JR, Flandin G, Seghier ML, Friston KJ. Multinomial inference on distributed responses in SPM. Neuroimage. 2010 Oct 15;53(1):161-70. Epub 2010 Jun 4.

150. Bach DR, Daunizeau J, Kuelzow N, Friston KJ, Dolan RJ. Dynamic causal modeling of spontaneous fluctuations in skin conductance. Psychophysiology. 2010 Jun 16. doi: 10.1111/j.1469-8986.2010.01052.x. [Epub ahead of print]

151. Hesselmann G, Sadaghiani S, Friston KJ, Kleinschmidt A. Predictive coding or evidence accumulation? False inference and neuronal fluctuations. PLoS One. 2010 Mar 29;5(3):e9926.

152. Penny WD, Stephan KE, Daunizeau J, Rosa MJ, Friston KJ, Schofield TM, Leff AP. Comparing families of dynamic causal models. PLoS Comput Biol. 2010 Mar 12;6(3):e1000709.

153. den Ouden HE, Daunizeau J, Roiser J, Friston KJ, Stephan KE. Striatal prediction error modulates cortical coupling. J Neurosci. 2010 Mar 3;30(9):3210-9.

154. Carhart-Harris RL, Friston KJ. The default-mode, ego-functions and free-energy: a neurobiological account of Freudian ideas. Brain. 2010 Apr;133(Pt 4):1265-83. Epub 2010 Feb 28. Review.

155. Friston KJ, Daunizeau J, Kilner J, Kiebel SJ. Action and behavior: a free-energy formulation. Biol Cybern. 2010 Mar;102(3):227-60. Epub 2010 Feb 11.

156. Bach DR, Friston KJ, Dolan RJ. Analytic measures for quantification of arousal from spontaneous skin conductance fluctuations. Int J Psychophysiol. 2010 Apr;76(1):52-5. Epub 2010 Feb 6.

157. Marreiros AC, Kiebel SJ, Friston KJ. A dynamic causal model study of neuronal population dynamics. Marreiros AC, Kiebel SJ, Friston KJ. Neuroimage. 2010 May 15;51(1):91-101. Epub 2010 Feb 2.

158. Bach DR, Flandin G, Friston KJ, Dolan RJ. Modelling event-related skin conductance responses. Int J Psychophysiol. 2010 Mar;75(3):349-56. Epub 2010 Jan 20.

159. Henson RN, Flandin G, Friston KJ, Mattout J. A parametric empirical Bayesian framework for fMRI- constrained MEG/EEG source reconstruction.Hum Brain Mapp. 2010 Oct;31(10):1512-31.

160. Friston K. The free-energy principle: a unified brain theory? Nat Rev Neurosci. 2010 Feb;11(2):127-38. Epub 2010 Jan 13. Review.

161. Litvak V, Eusebio A, Jha A, Oostenveld R, Barnes GR, Penny WD, Zrinzo L, Hariz MI, Limousin P, Friston KJ, Brown P. Optimized beamforming for simultaneous MEG and intracranial local field potential recordings in deep brain stimulation patients. Neuroimage. 2010 May 1;50(4):1578-88. Epub 2010 Jan 4.

119

162. Friston KJ, Dolan RJ. Computational and dynamic models in neuroimaging. Neuroimage. 2010 Sep;52(3):752-65. Epub 2009 Dec 28. Review.

163. Roiser JP, Stephan KE, den Ouden HE, Friston KJ, Joyce EM Adaptive and aberrant reward prediction signals in the human brain. Neuroimage. 2010 Apr 1;50(2):657-64. Epub 2009 Dec 5.

164. Daunizeau J, David O, Stephan KE. Dynamic causal modelling: A critical review of the biophysical and statistical foundations. Neuroimage. 2009 Dec 1. [Epub ahead of print]

165. Chumbley J, Worsley K, Flandin G, Friston K. Topological FDR for neuroimaging. Neuroimage. 2010 Feb 15;49(4):3057-64. Epub 2009 Nov 24.

166. Stephan KE, Penny WD, Moran RJ, den Ouden HE, Daunizeau J, Friston KJ. Ten simple rules for dynamic causal modeling. Neuroimage. 2010 Feb 15;49(4):3099-109. Epub 2009 Nov 12.

167. Daunizeau J, Friston KJ, Kiebel SJ. Variational Bayesian identification and prediction of stochastic nonlinear dynamic causal models. Physica D. 2009 Nov 1;238(21):2089-2118.

168. Friston KJ. Modalities, modes, and models in functional neuroimaging. Science. 2009 Oct 16;326(5951):399-403.

169. Friston K. Dynamic causal modeling and Granger causality Comments on: The identification of interacting networks in the brain using fMRI: Model selection, causality and deconvolution. Neuroimage. 2009 Sep 19. [Epub ahead of print].

170. Bach DR, Flandin G, Friston KJ, Dolan RJ. Time-series analysis for rapid event-related skin conductance responses. J Neurosci Methods. 2009 Nov 15;184(2):224-34. Epub 2009 Aug 15.

171. Kiebel SJ, von Kriegstein K, Daunizeau J, Friston KJ. Recognizing sequences of sequences. PLoS Comput Biol. 2009 Aug;5(8):e1000464. Epub 2009 Aug 14.

172. Kilner JM, Neal A, Weiskopf N, Friston KJ, Frith CD. Evidence of mirror neurons in human inferior frontal gyrus. J Neurosci. 2009 Aug 12;29(32):10153-9.

173. Vaudano AE, Laufs H, Kiebel SJ, Carmichael DW, Hamandi K, Guye M, Thornton R, Rodionov R, Friston KJ, Duncan JS, Lemieux L. Causal hierarchy within the thalamo-cortical network in spike and wave discharges. PLoS One. 2009 Aug 3;4(8):e6475.

174. Kiebel SJ, Daunizeau J, Friston KJ. Perception and hierarchical dynamics. Front Neuroinformatics. 2009;3:20. Epub 2009 Jul 20.

175. Friston KJ, Daunizeau J, Kiebel SJ. Reinforcement learning or active inference? PLoS One. 2009 Jul 29;4(7):e6421.

176. Pine A, Seymour B, Roiser JP, Bossaerts P, Friston KJ, Curran HV, Dolan RJ. Encoding of marginal utility across time in the human brain. J Neurosci. 2009 Jul 29;29(30):9575-81.

177. Friston K, Kiebel S. Cortical circuits for perceptual inference. Neural Netw. 2009 Oct;22(8):1093-104. Epub 2009 Jul 19.

178. Furl N, van Rijsbergen NJ, Kiebel SJ, Friston KJ, Treves A, Dolan RJ. Modulation of Perception and Brain Activity by Predictable Trajectories of Facial Expressions. Cereb Cortex. 2010 Mar;20(3):694-703. Epub 2009 Jul 17

179. Penny WD, Litvak V, Fuentemilla L, Duzel E, Friston K. Dynamic Causal Models for phase coupling. J Neurosci Methods. 2009 Sep 30;183(1):19-30. Epub 2009 Jul 2.

120

180. Friston K. The free-energy principle: a rough guide to the brain? Trends Cogn Sci. 2009 Jul;13(7):293-301. Epub 2009 Jun 24.

181. Schofield TM, Iverson P, Kiebel SJ, Stephan KE, Kilner JM, Friston KJ, Crinion JT, Price CJ, Leff AP. Changing meaning causes coupling changes within higher levels of the cortical hierarchy. Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11765-70. Epub 2009 Jun 24.

182. Garrido MI, Kilner JM, Kiebel SJ, Stephan KE, Baldeweg T, Friston KJ. Repetition suppression and plasticity in the human brain. Neuroimage. 2009 Oct 15;48(1):269-79. Epub 2009 Jun 21.

183. Friston K, Kiebel S. Predictive coding under the free-energy principle. Philos Trans R Soc Lond B Biol Sci. 2009 May 12;364(1521):1211-21.

184. Stephan KE, Tittgemeyer M, Knösche TR, Moran RJ, Friston KJ. Tractography-based priors for dynamic causal models. Neuroimage. 2009 Oct 1;47(4):1628-38. Epub 2009 Jun 10.

185. Henson RN, Mattout J, Phillips C, Friston KJ. Selecting forward models for MEG source-reconstruction using model-evidence. Neuroimage. 2009 May 15;46(1):168-76. Epub 2009 Feb 11.

186. Henson RN, Mouchlianitis E, Friston KJ. MEG and EEG data fusion: simultaneous localisation of face-evoked responses. Neuroimage. 2009 Aug 15;47(2):581-9. Epub 2009 May 3.

187. Daunizeau J, Kiebel SJ, Friston KJ. Dynamic causal modelling of distributed electromagnetic responses. Neuroimage. 2009 Aug 15;47(2):590-601. Epub 2009 May 3.

188. Taylor J, Evans A, Friston K. A tribute to: Keith Worsley--1951-2009. Neuroimage. 2009 Jul 15;46(4):891-4.

189. Kiebel SJ, Garrido MI, Moran R, Chen CC, Friston KJ. Dynamic causal modeling for EEG and MEG. Hum Brain Mapp. 2009 Jun;30(6):1866-76.

190. Stephan KE, Penny WD, Daunizeau J, Moran RJ, Friston KJ. Bayesian model selection for group studies. Neuroimage. 2009 Jul 15;46(4):1004-17. Epub 2009 Mar 20. Erratum in: Neuroimage. 2009 Oct 15;48(1):311.

191. Garrido MI, Kilner JM, Kiebel SJ, Friston KJ. Dynamic causal modeling of the response to frequency deviants. J Neurophysiol. 2009 May;101(5):2620-31. Epub 2009 Mar 4.

192. Leff AP, Iverson P, Schofield TM, Kilner JM, Crinion JT, Friston KJ, Price CJ. Vowel-specific mismatch responses in the anterior superior temporal gyrus: an fMRI study. Cortex. 2009 Apr;45(4):517-26.

193. Friston K. Causal modelling and brain connectivity in functional magnetic resonance imaging. PLoS Biol. 2009 Feb 17;7(2):e33. No abstract available.

194. Garrido MI, Kilner JM, Stephan KE, Friston KJ. : The mismatch negativity: A review of underlying mechanisms. 2009 Mar;120(3):453-63.

195. Chen CC, Henson RN, Stephan KE, Kilner JM, Friston KJ. Forward and backward connections in the brain: a DCM study of functional asymmetries. Neuroimage. 2009 Apr 1;45(2):453-62. Epub 2008 Dec 31.

196. Stephan KE, Friston KJ, Frith CD. Dysconnection in Schizophrenia: From Abnormal Synaptic Plasticity to Failures of Self-monitoring. Schizophr Bull. 2009 May;35(3):509-27. Epub 2009 Jan 20.

197. Ashburner J, Friston KJ. Computing average shaped tissue probability templates. Neuroimage. 2009 Apr 1;45(2):333-41. Epub 2008 Dec 24.

198. Mancini L, Ciccarelli O, Manfredonia F, Thornton JS, Agosta F, Barkhof F, Beckmann C, De Stefano N, Enzinger C, Fazekas F, Filippi M, Gass A, Hirsch JG, Johansen-Berg H, Kappos L, Korteweg T, Manson SC, Marino S,

121

Matthews PM, Montalban X, Palace J, Polman C, Rocca M, Ropele S, Rovira A, Wegner C, Friston K, Thompson A, Yousry T. Short-term adaptation to a simple motor task: a physiological process preserved in multiple sclerosis. Neuroimage. 2009 Apr 1;45(2):500-11. Epub 2008 Dec 24.

199. Yoshida W, Dolan RJ, Friston KJ. Game theory of mind. PLoS Comput Biol. 2008 Dec;4(12):e1000254. Epub 2008 Dec 26.

200. Leff AP, Schofield TM, Stephan KE, Crinion JT, Friston KJ, Price CJ. The cortical dynamics of intelligible speech. J Neurosci. 2008 Dec 3;28(49):13209-15.

201. Marreiros AC, Kiebel SJ, Daunizeau J, Harrison LM, Friston KJ. Population dynamics under the Laplace assumption. Neuroimage. 2009 Feb 1;44(3):701-14. Epub 2008 Oct 25.

202. Kiebel SJ, Daunizeau J, Friston KJ. A hierarchy of time-scales and the brain. PLoS Comput Biol. 2008 Nov;4(11):e1000209. Epub 2008 Nov 14.

203. Kiebel SJ, Garrido MI, Moran RJ, Friston KJ. Dynamic causal modelling for EEG and MEG. Cogn Neurodyn. 2008 Jun;2(2):121-36. Epub 2008 Apr 23.

204. Moran RJ, Stephan KE, Seidenbecher T, Pape HC, Dolan RJ, Friston KJ. Dynamic causal models of steady-state responses. Neuroimage. 2009 Feb 1;44(3):796-811. Epub 2008 Oct 17.

205. Friston K. Hierarchical models in the brain. PLoS Comput Biol. 2008 Nov;4(11):e1000211. Epub 2008 Nov 7.

206. Brodersen KH, Penny WD, Harrison LM, Daunizeau J, Ruff CC, Duzel E, Friston KJ, Stephan KE. Integrated Bayesian models of learning and decision making for saccadic eye movements. Neural Netw. 2008 Nov;21(9):1247-60. Epub 2008 Sep 7.

207. Hulme OJ, Friston KF, Zeki S. Neural Correlates of Stimulus Reportability. J Cogn Neurosci. 2009 Aug;21(8):1602-10.

208. den Ouden HE, Friston KJ, Daw ND, McIntosh AR, Stephan KE. A Dual Role for Prediction Error in Associative Learning. Cereb Cortex. 2009 May;19(5):1175-85. Epub 2008 Sep 26

209. Harrison LM, Penny W, Flandin G, Ruff CC, Weiskopf N, Friston KJ. Graph-partitioned spatial priors for functional magnetic resonance images. Neuroimage. 2008 Dec;43(4):694-707. Epub 2008 Aug 23.

210. Deco G, Jirsa VK, Robinson PA, Breakspear M, Friston K. The dynamic brain: from spiking neurons to neural masses and cortical fields. LoS Comput Biol. 2008 Aug 29;4(8):e1000092.

211. Friston K. Mean-fields and neural masses. PLoS Comput Biol. 2008 Aug 29;4(8):e1000081. No abstract available.

212. Fastenrath M, Friston KJ, Kiebel SJ. Dynamical causal modelling for M/EEG: spatial and temporal symmetry constraints. Neuroimage. 2009 Jan 1;44(1):154-63. Epub 2008 Jul 30.

213. Pastor MA, Vidaurre C, Fernández-Seara MA, Villanueva A, Friston KJ. Frequency-specific coupling in the cortico-cerebellar auditory system. J Neurophysiol. 2008 Oct;100(4):1699-705. Epub 2008 Aug 6.

214. Hohwy J, Roepstorff A, Friston K. Predictive coding explains binocular rivalry: An epistemological review. Cognition. 2008 Sep;108(3):687-701. Epub 2008 Jul 22.

215. Litvak V, Friston K. Electromagnetic source reconstruction for group studies. Neuroimage. 2008 Oct 1;42(4):1490-8. Epub 2008 Jun 27.

122

216. Chumbley JR, Friston KJ. False discovery rate revisited: FDR and topological inference using Gaussian random fields. Neuroimage. 2008 Jan 1;44(1):62-70..

217. Garrido MI, Friston KJ, Kiebel SJ, Stephan KE, Baldeweg T, Kilner JM. The functional anatomy of the MMN: a DCM study of the roving paradigm. Neuroimage. 2008 Aug 15;42(2):936-44. Epub 2008 May 20.

218. Roiser JP, Stephan KE, Ouden HE, Barnes TR, Friston KJ, Joyce EM. Do patients with schizophrenia exhibit aberrant salience? Psychol Med. 2008 Jun 30:1-11.

219. Stephan KE, Kasper L, Harrison LM, Daunizeau J, den Ouden HE, Breakspear M, Friston KJ. Nonlinear dynamic causal models for fMRI. Neuroimage. 2008 Aug 15;42(2):649-62. Epub 2008 May 11.

220. Marreiros AC, Daunizeau J, Kiebel SJ, Friston KJ. Population dynamics: variance and the sigmoid activation function. Neuroimage. 2008 Aug 1;42(1):147-57. Epub 2008 Apr 29.

221. Moran RJ, Stephan KE, Kiebel SJ, Rombach N, O'Connor WT, Murphy KJ, Reilly RB, Friston KJ. Bayesian estimation of synaptic physiology from the spectral responses of neural masses. Neuroimage. 2008 Aug 1;42(1):272-84. Epub 2008 Feb 1.

222. Friston K. Neurophysiology: the brain at work. Curr Biol. 2008 May 20;18(10):R418-20.

223. Chen CC, Kiebel SJ, Friston KJ. Dynamic causal modelling of induced responses. Neuroimage. 2008 Jul 15;41(4):1293-312. Epub 2008 Mar 28.

224. Bestmann S, Harrison LM, Blankenburg F, Mars RB, Haggard P, Friston KJ, Rothwell JC. Influence of uncertainty and surprise on human corticospinal excitability during preparation for action. Curr Biol. 2008 May 20;18(10):775-80.

225. Friston KJ. Variational filtering. Neuroimage. 2008 Jul 1;41(3):747-66. Epub 2008 Mar 20.

226. Friston KJ, Trujillo-Barreto N, Daunizeau J. DEM: a variational treatment of dynamic systems. Neuroimage. 2008 Jul 1;41(3):849-85. Epub 2008 Mar 10.

227. Harrison LM, Penny W, Daunizeau J, Friston KJ. Diffusion-based spatial priors for functional magnetic resonance images. NeuroImage. 2008 Jun;41(2):408-23. Epub 2008 Feb 20.

228. Mattout J, Henson RN, Friston KJ. Canonical Source Reconstruction for MEG. Comput Intell Neurosci. 2007:67613. PMID: 18350131

229. Garrido MI, Kilner JM, Kiebel SJ, Friston KJ. Evoked brain responses are generated by feedback loops. Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20961-6.

230. Chumbley JR, Dolan RJ, Friston KJ. Attractor models of working memory and their modulation by reward. Biol Cybern. 2008 Jan;98(1):11-8.

231. Friston K, Harrison L, Daunizeau J, Kiebel S, Phillips C, Trujillo-Barreto N, Henson R, Flandin G, Mattout J. Multiple sparse priors for the M/EEG inverse problem. Neuroimage. 2007 Oct 10;

232. Kiebel SJ, Daunizeau J, Phillips C, Friston KJ. Variational Bayesian inversion of the equivalent current dipole model in EEG/MEG. Neuroimage. 2008 Jan 15;39(2):728-41.

233. Marreiros AC, Kiebel SJ, Friston KJ. Dynamic causal modelling for fMRI: A two-state model. Neuroimage. 2008 Jan 1;39(1):269-78.

234. Friston K, Chu C, Mourão-Miranda J, Hulme O, Rees G, Penny W, Ashburner J. Bayesian decoding of brain images. Neuroimage. 2008 Jan 1;39(1):181-205.

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235. Henson RN, Mattout J, Singh KD, Barnes GR, Hillebrand A, Friston K. Population-level inferences for distributed MEG source localization under multiple constraints: application to face-evoked fields. Neuroimage. 2007 Nov 15;38(3):422-38.

236. Stephan KE, Weiskopf N, Drysdale PM, Robinson PA, Friston KJ. Comparing hemodynamic models with DCM. Neuroimage. 2007 Nov 15;38(3):387-401.

237. Chumbley JR, Friston KJ, Fearn T, Kiebel SJ. A Metropolis-Hastings algorithm for dynamic causal models. Neuroimage. 2007 Nov 15;38(3):478-87.

238. Harrison LM, Penny W, Ashburner J, Trujillo-Barreto N, Friston KJ. Diffusion-based spatial priors for imaging. Neuroimage. 2007 Dec;38(4):677-95.

239. Daunizeau J, Friston KJ. A mesostate-space model for EEG and MEG. Neuroimage. 2007 Oct 15;38(1):67-81.

240. Furl N, van Rijsbergen NJ, Treves A, Friston KJ, Dolan RJ. Experience-dependent coding of facial expression in superior temporal sulcus. Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13485-9.

241. Moran RJ, Kiebel SJ, Stephan KE, Reilly RB, Daunizeau J, Friston KJ. A neural mass model of spectral responses in electrophysiology. Neuroimage. 2007 Sep 1;37(3):706-20.

242. Noppeney U, Josephs O, Hocking J, Price CJ, Friston KJ. The Effect of Prior Visual Information on Recognition of Speech and Sounds. Cereb Cortex. 2008 Mar;18(3):598-609. Epub 2007 Jul 7.

243. Crinion J, Ashburner J, Leff A, Brett M, Price C, Friston K. Spatial normalization of lesioned brains: performance evaluation and impact on fMRI analyses. Neuroimage. 2007 Sep 1;37(3):866-75.

244. Kumar S, Stephan KE, Warren JD, Friston KJ, Griffiths TD. Hierarchical processing of auditory objects in humans. PLoS Comput Biol. 2007 Jun;3(6):e100. Epub 2007 Apr 24.

245. Garrido MI, Kilner JM, Kiebel SJ, Stephan KE, Friston KJ. Dynamic causal modelling of evoked potentials: a reproducibility study. Neuroimage. 2007 Jul 1;36(3):571-80.

246. Seghier ML, Friston KJ, Price CJ. Detecting subject-specific activations using fuzzy clustering. Neuroimage. 2007 Jul 1;36(3):594-605.

247. Kiebel SJ, Garrido MI, Friston KJ. Dynamic causal modelling of evoked responses: The role of intrinsic connections. Neuroimage. 2007 Jun;36(2):332-45..

248. Kilner JM, Friston KJ, Frith CD. Predictive coding: an account of the mirror neuron system.Cogn Process. 2007 Sep;8(3):159-66. Epub 2007 Apr 12.

249. Stephan KE, Harrison LM, Kiebel SJ, David O, Penny WD, Friston KJ. Dynamic causal models of neural system dynamics: current state and future extensions. J Biosci. 2007 Jan;32(1):129-44.

250. Kilner JM, Friston KJ, Frith CD. The mirror-neuron system: a Bayesian perspective. Neuroreport. 2007 Apr 16;18(6):619-23.

251. Mourao-Miranda J, Friston KJ, Brammer M. Dynamic discrimination analysis: A spatial-temporal SVM. Neuroimage. 2007 May 15;36(1):88-99.

252. Stephan KE, Marshall JC, Penny WD, Friston KJ, Fink GR. Interhemispheric integration of visual processing during task-driven lateralization. J Neurosci. 2007 Mar 28;27(13):3512-22.

253. Griffiths TD, Kumar S, Warren JD, Stewart L, Stephan KE, Friston KJ. Approaches to the cortical analysis of auditory objects. Hear Res. 2007 Jul;229(1-2):46-53. Epub 2007 Jan 16]

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254. Harrison LM, Stephan KE, Rees G, Friston KJ. Extra-classical receptive field effects measured in striate cortex with fMRI. Neuroimage. 2007 Feb 1;34(3):1199-208.

255. Kiebel SJ, Kloppel S, Weiskopf N, Friston KJ. Dynamic causal modeling: a generative model of slice timing in fMRI. Neuroimage. 2007 Feb 15;34(4):1487-96.

256. Pleger B, Ruff CC, Blankenburg F, Bestmann S, Wiech K, Stephan KE, Capilla A, Friston KJ, Dolan RJ. Neural coding of tactile decisions in the human prefrontal cortex. J Neurosci. 2006 Nov 29;26(48):12596-601.

257. Friston K, Kilner J, Harrison L. A free energy principle for the brain. J Physiol Paris. 2006 Jul-Sep;100(1-3):70- 87.

258. Friston K, Mattout J, Trujillo-Barreto N, Ashburner J, Penny W. Variational free energy and the Laplace approximation. Neuroimage. 2007 Jan 1;34(1):220-34.

259. Rounis E, Stephan KE, Lee L, Siebner HR, Pesenti A, Friston KJ, Rothwell JC, Frackowiak RS. Acute changes in frontoparietal activity after repetitive transcranial magnetic stimulation over the dorsolateral prefrontal cortex in a cued reaction time task. J Neurosci. 2006 Sep 20;26(38):9629-38.

260. Mouridsen K, Friston K, Hjort N, Gyldensted L, Ostergaard L, Kiebel S. Bayesian estimation of cerebral perfusion using a physiological model of microvasculature. Neuroimage. 2006 Nov 1;33(2):570-9.

261. Sugiura M, Friston KJ, Willmes K, Shah NJ, Zilles K, Fink GR. Analysis of intersubject variability in activation: an application to the incidental episodic retrieval during recognition test. Hum Brain Mapp. 2007 Jan;28(1):49- 58

262. Newton JM, Ward NS, Parker GJ, Deichmann R, Alexander DC, Friston KJ, Frackowiak RS. Non-invasive mapping of corticofugal fibres from multiple motor areas--relevance to stroke recovery. Brain. 2006 Jul;129(Pt 7):1844-58.

263. Salek-Haddadi A, Diehl B, Hamandi K, Merschhemke M, Liston A, Friston K, Duncan JS, Fish DR, Lemieux L. Hemodynamic correlates of epileptiform discharges: an EEG-fMRI study of 63 patients with focal epilepsy. Brain Res. 2006 May 9;1088(1):148-66.

264. Price CJ, Crinion J, Friston KJ. Design and analysis of fMRI studies with neurologically impaired patients. J Magn Reson Imaging. 2006 Jun;23(6):816-26.

265. Friston KJ, Rotshtein P, Geng JJ, Sterzer P, Henson RN. A critique of functional localisers. Neuroimage. 2006 May 1;30(4):1077-87.

266. David O, Kilner JM, Friston KJ. Mechanisms of evoked and induced responses in MEG/EEG. Neuroimage. 2006 Jul 15;31(4):1580-91.

267. Hamandi K, Salek-Haddadi A, Laufs H, Liston A, Friston K, Fish DR, Duncan JS, Lemieux L. EEG-fMRI of idiopathic and secondarily generalized epilepsies. Neuroimage. 2006 Jul 15;31(4):1700-10.

268. Friston KJ, Henson RN. Commentary on: Divide and conquer; a defence of functional localisers. Neuroimage. 2006 May 1;30(4):1097-9.

269. Harrison LM, Duggins A, Friston KJ. Encoding uncertainty in the hippocampus. Neural Netw. 2006 Jun;19(5):535-46.

270. Kiebel SJ, David O, Friston KJ. Dynamic causal modelling of evoked responses in EEG/MEG with lead field parameterization. Neuroimage. 2006 May 1;30(4):1273-84.

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271. Pleger B, Blankenburg F, Bestmann S, Ruff CC, Wiech K, Stephan KE, Friston KJ, Dolan RJ. Repetitive transcranial magnetic stimulation-induced changes in sensorimotor coupling parallel improvements of somatosensation in humans. J Neurosci. 2006 Feb 15;26(7):1945-52.

272. David O, Kiebel SJ, Harrison LM, Mattout J, Kilner JM, Friston KJ. Dynamic causal modeling of evoked responses in EEG and MEG. Neuroimage. 2006 May 1;30(4):1255-72.

273. Friston K, Henson R, Phillips C, Mattout J. Bayesian estimation of evoked and induced responses. Hum Brain Mapp. 2006 Feb 1;27(9):722-735

274. Stephan KE, Baldeweg T, Friston KJ. Synaptic plasticity and dysconnection in schizophrenia. Biol Psychiatry. 2006 May 15;59(10):929-39. Epub 2006 Jan 19. Review.

275. Stephan KE, Penny WD, Marshall JC, Fink GR, Friston KJ. Investigating the functional role of callosal connections with dynamic causal models. Ann N Y Acad Sci. 2005 Dec;1064:16-36.

276. Lee L, Friston K, Horwitz B. Large-scale neural models and dynamic causal modelling. Neuroimage. 2006 May 1;30(4):1243-54.

277. Friston KJ, Penny W, David O. Modeling brain responses. Int Rev Neurobiol. 2005;66:89-124.

278. Friston KJ. Hallucinations and perceptual inference. Behav Brain Sci. 2005 Dec;28(6):764-6.

279. Mattout J, Phillips C, Penny WD, Rugg MD, Friston KJ. MEG source localization under multiple constraints: An extended Bayesian framework. Neuroimage. 2006 Apr 15;30(3):753-67.

280. Liston AD, Lund TE, Salek-Haddadi A, Hamandi K, Friston KJ, Lemieux L. Modelling cardiac signal as a confound in EEG-fMRI and its application in focal epilepsy studies. Neuroimage. 2006 Apr 15;30(3):827-34. Epub 2005 Dec 15.]

281. Noppeney U, Penny WD, Price CJ, Flandin G, Friston KJ. Identification of degenerate neuronal systems based on intersubject variability.Neuroimage. 2006 Apr 15;30(3):885-90. Epub 2005 Nov 21.

282. Mechelli A, Crinion JT, Long S, Friston KJ, Lambon Ralph MA, Patterson K, McClelland JL, Price CJ. Dissociating reading processes on the basis of neuronal interactions. J Cogn Neurosci. 2005 Nov;17(11):1753-65.

283. Noppeney U, Josephs O, Kiebel S, Friston KJ, Price CJ. Action selectivity in parietal and temporal cortex. Brain Res Cogn Brain Res. 2005 Dec;25(3):641-9. Epub 2005 Oct 20.

284. Mechelli A, Friston KJ, Frackowiak RS, Price CJ. Structural covariance in the human cortex. J Neurosci. 2005 Sep 7;25(36):8303-10.

285. Seymour B, O'doherty JP, Koltzenburg M, Wiech K, Frackowiak R, Friston K, Dolan R Opponent appetitive- aversive neural processes underlie predictive learning of pain relief. Nat Neurosci. 2005 Sep;8(9):1234-40. Epub 2005 Aug 21]

286. Salmond CH, Ashburner J, Connelly A, Friston KJ, Gadian DG, Vargha-Khadem F. The role of the Medial temporal lobe in autistic spectrum disorders. Eur J Neurosci. 2005 Aug;22(3):764-72.

287. Afridi SK, Giffin NJ, Kaube H, Friston KJ, Ward NS, Frackowiak RS, Goadsby PJ. A positron emission tomographic study in spontaneous migraine. Arch Neurol. 2005 Aug;62(8):1270-5.

288. Harrison LM, David O, Friston KJ. Stochastic models of neuronal dynamics. Philos Trans R Soc Lond B Biol Sci. 2005 May 29;360(1457):1075-91.

289. Penny W, Ghahramani Z, Friston K Bilinear dynamical systems. Philos Trans R Soc Lond B Biol Sci. 2005 May 29;360(1457):983-93.

126

290. Valdes-Sosa PA, Kotter R, Friston KJ. Introduction: multimodal neuroimaging of brain connectivity. Philos Trans R Soc Lond B Biol Sci. 2005 May 29;360(1457):865-7.

291. Noppeney U, Friston KJ, Ashburner J, Frackowiak R, Price CJ. Early visual deprivation induces structural plasticity in gray and white matter. Curr Biol. 2005 Jul 12;15(13):R488-90.

292. Kilner JM, Mattout J, Henson R, Friston KJ. Hemodynamic correlates of EEG: A heuristic. Neuroimage. 2005 Oct 15;28(1):280-6. Epub 2005 Jul 14.

293. Ashburner J, Friston KJ. Unified segmentation. Neuroimage. 2005 Jul 1;26(3):839-51.

294. Noppeney U, Price CJ, Penny WD, Friston KJ. Two Distinct Neural Mechanisms for Category-selective Responses. Cereb Cortex. 2006 Mar;16(3):437-45. Epub 2005 Jun 8

295. Kulkarni B, Bentley DE, Elliott R, Youell P, Watson A, Derbyshire SW, Frackowiak RS, Friston KJ, Jones AK. Attention to pain localization and unpleasantness discriminates the functions of the Medial and lateral pain systems. Eur J Neurosci. 2005 Jun;21(11):3133-42.

296. Kiebel SJ, Tallon-Baudry C, Friston KJ. Parametric analysis of oscillatory activity as measured with EEG/MEG.Hum Brain Mapp. 2005 Nov;26(3):170-7.

297. Rounis E, Lee L, Siebner HR, Rowe JB, Friston KJ, Rothwell JC, Frackowiak RS. Frequency specific changes in regional cerebral blood flow and motor system connectivity following rTMS to the primary motor cortex. Neuroimage. 2005 May 15;26(1):164-76.

298. Friston K. A theory of cortical responses. Philos Trans R Soc Lond B Biol Sci. 2005 Apr 29;360(1456):815-36.

299. David O, Harrison L, Friston KJ. Modelling event-related responses in the brain. Neuroimage. 2005 Apr 15;25(3):756-70.

300. Hu D, Yan L, Liu Y, Zhou Z, Friston KJ, Tan C, Wu D. Unified SPM-ICA for fMRI analysis. Neuroimage. 2005 Apr 15;25(3):746-55.

301. Friston KJ, Penny WD, Glaser DE. Conjunction revisited. Neuroimage. 2005 Apr 15;25(3):661-7.

302. Afridi SK, Matharu MS, Lee L, Kaube H, Friston KJ, Frackowiak RS, Goadsby PJ. A PET study exploring the laterality of brainstem activation in migraine using glyceryl trinitrate. Brain. 2005 Apr;128(Pt 4):932-9.

303. Strange BA, Duggins A, Penny W, Dolan RJ, Friston KJ. Information theory, novelty and hippocampal responses: unpredicted orunpredictable? Neural Netw. 2005 Apr;18(3):225-30.

304. Friston K. Disconnection and cognitive dysmetria in schizophrenia. Am J Psychiatry. 2005 Mar;162(3):429-32.

305. Graydon FX, Friston KJ, Thomas CG, Brooks VB, Menon RS. Learning-related fMRI activation associated with a rotational visuo-motor transformation. Brain Res Cogn Brain Res. 2005 Mar;22(3):373-83.

306. Kilner JM, Kiebel SJ, Friston KJ. Applications of random field theory to electrophysiology. Neurosci Lett. 2005 Feb 21;374(3):174-8.

307. Schultz J, Friston KJ, O'Doherty J, Wolpert DM, Frith CD. Activation in posterior superior temporal sulcus parallels parameter inducing the percept of animacy. Neuron. 2005 Feb 17;45(4):625-35.

308. Phillips C, Mattout J, Rugg MD, Maquet P, Friston KJ. An empirical Bayesian solution to the source reconstruction problem in EEG. Neuroimage. 2005 Feb 15;24(4):997-1011.

127

309. Penny WD, Trujillo-Barreto NJ, Friston KJ. Bayesian fMRI time series analysis with spatial priors. Neuroimage. 2005 Jan 15;24(2):350-62.

310. Friston KJ. Models of brain function in neuroimaging. Annu Rev Psychol. 2005;56:57-87.

311. Rowe JB, Stephan KE, Friston K, Frackowiak RS, Passingham RE. The prefrontal cortex shows context-specific changes in effective connectivity to motor or visual cortex during the selection of action or colour. Cereb Cortex. 2005 Jan;15(1):85-95.

312. Friston KJ, Stephan KE, Lund TE, Morcom A, Kiebel S. Mixed-effects and fMRI studies. Neuroimage. 2005 Jan 1;24(1):244-52.

313. Noppeney U, Friston KJ, Price CJ. Degenerate neuronal systems sustaining cognitive functions. J Anat. 2004 Dec;205(6):433-42.

314. Mechelli A, Price CJ, Friston KJ, Ishai A. Where bottom-up meets top-down: neuronal interactions during perception and imagery. Cereb Cortex. 2004 Nov;14(11):1256-65. Epub 2004 Jun 10.

315. Stephan KE, Harrison LM, Penny WD, Friston KJ. Biophysical models of fMRI responses. Curr Opin Neurobiol. 2004 Oct;14(5):629-35.

316. Friston KJ, Ashburner J. Generative and recognition models for neuroanatomy. Neuroimage. 2004 Sep;23(1):21-4.

317. Penny WD, Stephan KE, Mechelli A, Friston KJ. Comparing dynamic causal models. Neuroimage. 2004 Jul;22(3):1157-72.

318. Seymour B, O'Doherty JP, Dayan P, Koltzenburg M, Jones AK, Dolan RJ, Friston KJ, Frackowiak RS. Temporal difference models describe higher-order learning in humans. Nature. 2004 Jun 10;429(6992):664-7.

319. Kiebel SJ, Friston KJ. Statistical parametric mapping for event-related potentials (II): a hierarchical temporal model. Neuroimage. 2004 Jun;22(2):503-20.

320. Kiebel SJ, Friston KJ. Statistical parametric mapping for event-related potentials: (I). Generic considerations. Neuroimage. 2004 Jun;22(2):492-502.

321. O'Doherty J, Dayan P, Schultz J, Deichmann R, Friston K, Dolan RJ. Dissociable roles of ventral and dorsal striatum in instrumental conditioning. Science. 2004 Apr 16;304(5669):452-4.

322. Pastor MA, Day BL, Macaluso E, Friston KJ, Frackowiak RS. The functional neuroanatomy of temporal discrimination. J Neurosci. 2004 Mar 10;24(10):2585-91.

323. David O, Cosmelli D, Friston KJ. Evaluation of different measures of functional connectivity using a neural mass model. Neuroimage. 2004 Feb;21(2):659-73.

324. Penny WD, Stephan KE, Mechelli A, Friston KJ. Modelling functional integration: a comparison of structural equation and dynamic causal models. Neuroimage. 2004;23 Suppl 1:S264-74.

325. Good CD, Lawrence K, Thomas NS, Price CJ, Ashburner J, Friston KJ, Frackowiak RS, Oreland L, Skuse DH. Dosage-sensitive X-linked locus influences the development of amygdala and orbitofrontal cortex, and fear recognition in humans. Brain. 2003 Nov;126(Pt 11):2431-46.

326. Breakspear M, Terry JR, Friston KJ. Modulation of excitatory synaptic coupling facilitates synchronization and complex dynamics in a biophysical model of neuronal dynamics. Network. 2003 Nov;14(4):703-32.

327. Friston K. Learning and inference in the brain. Neural Netw. 2003 Nov;16(9):1325-52.

128

328. David O, Friston KJ. A neural mass model for MEG/EEG: coupling and neuronal dynamics. Neuroimage. 2003 Nov;20(3):1743-55.

329. Mechelli A, Price CJ, Noppeney U, Friston KJ. A dynamic causal modeling study on category effects: bottom-up or top-down mediation? J Cogn Neurosci. 2003 Oct 1;15(7):925-34.

330. Salek-Haddadi A, Friston KJ, Lemieux L, Fish DR. Studying spontaneous EEG activity with fMRI. Brain Res Brain Res Rev. 2003 Sep;43(1):110-33.

331. Kiebel SJ, Glaser DE, Friston KJ. A heuristic for the degrees of freedom of statistics based on multiple variance parameters. Neuroimage. 2003 Sep;20(1):591-600.

332. Breakspear M, Terry JR, Friston KJ, Harris AW, Williams LM, Brown K, Brennan J, Gordon E. A disturbance of nonlinear interdependence in scalp EEG of subjects with first episode schizophrenia. Neuroimage. 2003 Sep;20(1):466-78.

333. Vargha-Khadem F, Salmond CH, Watkins KE, Friston KJ, Gadian DG, Mishkin M. Developmental amnesia: effect of age at injury. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):10055-60.

334. Harrison L, Penny WD, Friston K. Multivariate autoregressive modeling of fMRI time series. Neuroimage. 2003 Aug;19(4):1477-91.

335. Friston KJ, Harrison L, Penny W. Dynamic causal modelling. Neuroimage. 2003 Aug;19(4):1273-302.

336. Stephan KE, Marshall JC, Friston KJ, Rowe JB, Ritzl A, Zilles K, Fink GR. Lateralized cognitive processes and lateralized task control in the human brain. Science. 2003 Jul 18;301(5631):384-6.

337. Noppeney U, Friston KJ, Price CJ. Effects of visual deprivation on the organization of the semantic system. Brain. 2003 Jul;126(Pt 7):1620-7. Epub 2003 Apr 22.

338. Friston KJ, Penny W. Posterior probability maps and SPMs. Neuroimage. 2003 Jul;19(3):1240-9.

339. Penny W, Kiebel S, Friston K. Variational Bayesian inference for fMRI time series. Neuroimage. 2003 Jul;19(3):727-41.

340. Lee L, Siebner HR, Rowe JB, Rizzo V, Rothwell JC, Frackowiak RS, Friston KJ. Acute remapping within the motor system induced by low-frequency repetitive transcranial magnetic stimulation. J Neurosci. 2003 Jun 15;23(12):5308-18.

341. Salek-Haddadi A, Lemieux L, Merschhemke M, Friston KJ, Duncan JS, Fish DR. Functional magnetic resonance imaging of human absence seizures. Ann Neurol. 2003 May;53(5):663-7.

342. Gitelman DR, Penny WD, Ashburner J, Friston KJ. Modeling regional and psychophysiologic interactions in fMRI: the importance of hemodynamic deconvolution. Neuroimage. 2003 May;19(1):200-7.

343. O'Doherty JP, Dayan P, Friston K, Critchley H, Dolan RJ. Temporal difference models and reward-related learning in the human brain. Neuron. 2003 Apr 24;38(2):329-37.

344. Penny W, Friston K. Mixtures of general linear models for functional neuroimaging. IEEE Trans Med Imaging. 2003 Apr;22(4):504-14.

345. Friston KJ, Price CJ. Degeneracy and redundancy in cognitive anatomy. Trends Cogn Sci. 2003 Apr;7(4):151- 152.

346. Mechelli A, Henson RN, Price CJ, Friston KJ. Comparing event-related and epoch analysis in blocked design fMRI. Neuroimage. 2003 Mar;18(3):806-10.

129

347. Mechelli A, Price CJ, Henson RN, Friston KJ. Estimating efficiency a priori: a comparison of blocked and randomized designs. Neuroimage. 2003 Mar;18(3):798-805.

348. Salmond CH, de Haan M, Friston KJ, Gadian DG, Vargha-Khadem F. Investigating individual differences in brain abnormalities in autism. Philos Trans R Soc Lond B Biol Sci. 2003 Feb 28;358(1430):405-13.

349. Mechelli A, Penny WD, Price CJ, Gitelman DR, Friston KJ. Effective connectivity and intersubject variability: using a multisubjectnetwork to test differences and commonalities. Neuroimage. 2002 Nov;17(3):1459-69.

350. Veltman DJ, Mechelli A, Friston KJ, Price CJ. The importance of distributed sampling in blocked functional magnetic resonance imaging designs. Neuroimage. 2002 Nov;17(3):1203-6.

351. Salmond CH, Ashburner J, Vargha-Khadem F, Connelly A, Gadian DG, Friston KJ. Distributional assumptions in voxel-based morphometry. Neuroimage. 2002 Oct;17(2):1027-30.

352. Rowe J, Friston K, Frackowiak R, Passingham R. Attention to action: specific modulation of corticocortical interactions in humans. Neuroimage. 2002 Oct;17(2):988-98.

353. Friston K. Functional integration and inference in the brain. Prog Neurobiol. 2002 Oct;68(2):113-43.

354. Price CJ, Friston KJ. Degeneracy and cognitive anatomy. Trends Cogn Sci. 2002 Oct 1;6(10):416-421.

355. Salmond CH, Ashburner J, Vargha-Khadem F, Connelly A, Gadian DG, Friston KJ. The precision of anatomical normalization in the Medial temporal lobe using spatial basis functions. Neuroimage. 2002 Sep;17(1):507- 12.

356. Good CD, Scahill RI, Fox NC, Ashburner J, Friston KJ, Chan D, Crum WR, Rossor MN, Frackowiak RS. Automatic differentiation of anatomical patterns in the human brain: validation with studies of degenerative dementias. Neuroimage. 2002 Sep;17(1):29-46.

357. Thiel CM, Friston KJ, Dolan RJ. Cholinergic modulation of experience-dependent plasticity in human auditory cortex. Neuron. 2002 Aug 1;35(3):567-74.

358. Phillips C, Rugg MD, Friston KJ. Anatomically informed basis functions for EEG source localization: combining functional and anatomical constraints. Neuroimage. 2002 Jul;16(3 Pt 1):678-95.

359. Friston KJ. Dysfunctional connectivity in schizophrenia. World Psychiatry. 2002 Jun;1(2):66-71.

360. Lawrie SM, Buechel C, Whalley HC, Frith CD, Friston KJ, Johnstone EC. Reduced frontotemporal functional connectivity in schizophrenia associated with auditory hallucinations. Biol Psychiatry. 2002 Jun 15;51(12):1008-11.

361. Friston KJ. Bayesian estimation of dynamical systems: an application to fMRI. Neuroimage. 2002 Jun;16(2):513-30.

362. Friston KJ, Glaser DE, Henson RN, Kiebel S, Phillips C, Ashburner J. Classical and Bayesian inference in neuroimaging: applications. Neuroimage. 2002 Jun;16(2):484-512.

363. Friston KJ, Penny W, Phillips C, Kiebel S, Hinton G, Ashburner J. Classical and Bayesian inference in neuroimaging: theory. Neuroimage. 2002 Jun;16(2):465-83.

364. Kleinschmidt A, Buchel C, Hutton C, Friston KJ, Frackowiak RS. The neural structures expressing perceptual hysteresis in visual letter recognition.Neuron. 2002 May 16;34(4):659-66.

365. Kiebel S, Friston KJ. Anatomically informed basis functions in multisubject studies. Hum Brain Mapp. 2002 May;16(1):36-46.

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366. Gitelman DR, Parrish TB, Friston KJ, Mesulam MM. Functional anatomy of visual search: regional segregations within the frontal eye fields and effective connectivity of the superior colliculus. Neuroimage. 2002 Apr;15(4):970-82.

367. Watkins KE, Vargha-Khadem F, Ashburner J, Passingham RE, Connelly A, Friston KJ, Frackowiak RS, Mishkin M, Gadian DG. MRI analysis of an inherited speech and language disorder: structural brain abnormalities. Brain. 2002 Mar;125(Pt 3):465-78.

368. Devlin JT, Moore CJ, Mummery CJ, Gorno-Tempini ML, Phillips JA, Noppeney U, Frackowiak RS, Friston KJ, Price CJ. Anatomic constraints on cognitive theories of category specificity. Neuroimage. 2002 Mar;15(3):675- 85.

369. Rowe J, Stephan KE, Friston K, Frackowiak R, Lees A, Passingham R. Attention to action in Parkinson's disease: impaired effective connectivity among frontal cortical regions. Brain. 2002 Feb;125(Pt 2):276-89.

370. Friston K. Beyond phrenology: what can neuroimaging tell us about distributed circuitry? Annu Rev Neurosci. 2002;25:221-50. Epub 2002 Mar 19.

371. Price CJ, Friston KJ. Functional imaging studies of neuropsychological patients: applications and limitations. Neurocase. 2002;8(5):345-54.

372. Phillips C, Rugg MD & Friston KJ. Systematic Regularization of Linear Inverse Solutions of the EEG Source Localization Problem. NeuroImage 2002;17:287-301

373. Henson RN, Price CJ, Rugg MD, Turner R, Friston KJ. Detecting latency differences in event-related BOLD responses: application to words versus nonwords and initial versus repeated face presentations. Neuroimage. 2002 Jan;15(1):83-97.

374. Ashburner J, Friston KJ. Why voxel-based morphometry should be used. Neuroimage. 2001 Dec;14(6):1238- 43.

375. McIntosh AR, Fitzpatrick SM, Friston KJ. On the marriage of cognition and neuroscience. Neuroimage. 2001 Dec;14(6):1231-7.

376. Strange BA, Henson RN, Friston KJ, Dolan RJ. Anterior prefrontal cortex mediates rule learning in humans. Cereb Cortex. 2001 Nov;11(11):1040-6.

377. Mechelli A, Price CJ, Friston KJ. Nonlinear coupling between evoked rCBF and BOLD signals: a simulation study of hemodynamic responses. Neuroimage. 2001 Oct;14(4):862-72.

378. Friston KJ. Brain function, nonlinear coupling, and neuronal transients. Neuroscientist. 2001 Oct;7(5):406-18.

379. Thiel CM, Henson RN, Morris JS, Friston KJ, Dolan RJ. Pharmacological modulation of behavioral and neuronal correlates of repetition priming. J Neurosci. 2001 Sep 1;21(17):6846-52.

380. Good CD, Johnsrude I, Ashburner J, Henson RN, Friston KJ, Frackowiak RS. Cerebral asymmetry and the effects of sex and handedness on brain structure: a voxel-based morphometric analysis of 465 normal adult human brains. Neuroimage. 2001 Sep;14(3):685-700.

381. Buchel C, Friston K. Interactions among neuronal systems assessed with functional neuroimaging. Rev Neurol (Paris). 2001 Sep;157(8-9 Pt 1):807-15.

382. Chawla D, Friston KJ, Lumer ED. Zero-lag synchronous dynamics in triplets of interconnected cortical areas. Neural Netw. 2001 Jul-Sep;14(6-7):727-35.

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383. Good CD, Johnsrude IS, Ashburner J, Henson RN, Friston KJ, Frackowiak RS. A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage. 2001 Jul;14(1 Pt 1):21-36.

384. Friston KJ, Price CJ. Generative models, brain function and neuroimaging. Scand J Psychol. 2001 Jul;42(3):167- 77.

385. Andersson JL, Ashburner J, Friston K. A global estimator unbiased by local changes. Neuroimage. 2001 Jun;13(6 Pt 1):1193-206.

386. Price CJ, Warburton EA, Moore CJ, Frackowiak RS, Friston KJ. Dynamic diaschisis: anatomically remote and context-sensitive human brain lesions. J Cogn Neurosci. 2001 May 15;13(4):419-29.

387. Andersson JL, Hutton C, Ashburner J, Turner R, Friston K. Modeling geometric deformations in EPI time series. Neuroimage. 2001 May;13(5):903-19.

388. Gitelman DR, Ashburner J, Friston KJ, Tyler LK, Price CJ. Voxel-based morphometry of herpes simplex encephalitis. Neuroimage. 2001 Apr;13(4):623-31.

389. Friston KJ, Price CJ. Dynamic representations and generative models of brain function. Brain Res Bull. 2001 Feb;54(3):275-85.

390. Lipschutz B, Friston KJ, Ashburner J, Turner R, Price CJ. Assessing study-specific regional variations in fMRI signal. Neuroimage. 2001 Feb;13(2):392-8.

391. Chawla D, Lumer ED, Friston KJ. Relating macroscopic measures of brain activity to fast, dynamic neuronal interactions. Neural Comput. 2000 Dec;12(12):2805-21.

392. Salmond CH, Ashburner J, Vargha-Khadem F, Gadian DG, Friston KJ. Detecting bilateral abnormalities with voxel-based morphometry. Hum Brain Mapp. 2000 Nov;11(3):223-32.

393. Buchel C, Friston K. Assessing interactions among neuronal systems using functional neuroimaging. Neural Netw. 2000 Oct-Nov;13(8-9):871-82.

394. Horwitz B, Friston KJ, Taylor JG. Neural modeling and functional brain imaging: an overview. Neural Netw. 2000 Oct-Nov;13(8-9):829-46.

395. Worsley KJ & Friston KJ A test for a conjunction. Statistics & Probability Letters 2000; 47:135-140

396. Friston KJ, Mechelli A, Turner R, Price CJ. Nonlinear responses in fMRI: the Balloon model, Volterra kernels, and other hemodynamics. Neuroimage. 2000 Oct;12(4):466-77.

397. Strange BA, Henson RN, Friston KJ, Dolan RJ. Brain mechanisms for detecting perceptual, semantic, and emotional deviance. Neuroimage. 2000 Oct;12(4):425-33.

398. Elliott R, Friston KJ, Dolan RJ. Dissociable neural responses in human reward systems. J Neurosci. 2000 Aug 15;20(16):6159-65.

399. Sell LA, Morris JS, Bearn J, Frackowiak RS, Friston KJ, Dolan RJ. Neural responses associated with cue evoked emotional states and heroin in opiate addicts. Drug Alcohol Depend. 2000 Aug 1;60(2):207-16.

400. Friston KJ, Josephs O, Zarahn E, Holmes AP, Rouquette S, Poline J. To smooth or not to smooth? Bias and efficiency in fMRI time-series analysis. Neuroimage. 2000 Aug;12(2):196-208.

401. Rees G, Friston K, Koch C. A direct quantitative relationship between the functional properties of human and macaque V5. Nat Neurosci. 2000 Jul;3(7):716-23.

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402. Friston KJ, Buchel C. Attentional modulation of effective connectivity from V2 to V5/MT in humans. Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7591-6.

403. Ashburner J, Friston KJ. Voxel-based morphometry--the methods. Neuroimage. 2000 Jun;11(6 Pt 1):805-21.

404. McGonigle DJ, Howseman AM, Athwal BS, Friston KJ, Frackowiak RS, Holmes AP. Variability in fMRI: an examination of intersession differences. Neuroimage. 2000 Jun;11(6 Pt 1):708-34.

405. Kiebel SJ, Goebel R, Friston KJ. Anatomically informed basis functions. Neuroimage. 2000 Jun;11(6 Pt 1):656- 67.

406. Veltman DJ, Friston KJ, Sanders G, Price CJ. Regionally specific sensitivity differences in fMRI and PET: where do they come from? Neuroimage. 2000 Jun;11(6 Pt 1):575-88.

407. Scott SK, Holmes A, Friston KJ, Wise RJ. A thalamo-prefrontal system for representation in executive response choice. Neuroreport. 2000 May 15;11(7):1523-7.

408. Portas CM, Strange BA, Friston KJ, Dolan RJ, Frith CD. How does the brain sustain a visual percept? Proc Biol Sci. 2000 May 7;267(1446):845-50.

409. Ashburner J, Andersson JL, Friston KJ. Image registration using a symmetric prior--in three dimensions. Hum Brain Mapp. 2000 Apr;9(4):212-25.

410. Hopfinger JB, Buchel C, Holmes AP, Friston KJ. A study of analysis parameters that influence the sensitivity of event-related fMRI analyses. Neuroimage. 2000 Apr;11(4):326-33.

411. Friston KJ. The labile brain. III. Transients and spatio-temporal receptive fields. Philos Trans R Soc Lond B Biol Sci. 2000 Feb 29;355(1394):253-65.

412. Friston KJ. The labile brain. II. Transients, complexity and selection. Philos Trans R Soc Lond B Biol Sci. 2000 Feb 29;355(1394):237-52.

413. Friston KJ. The labile brain. I. Neuronal transients and nonlinear coupling. Philos Trans R Soc Lond B Biol Sci. 2000 Feb 29;355(1394):215-36.

414. Friston K, Phillips J, Chawla D, Buchel C. Nonlinear PCA: characterizing interactions between modes of brain activity. Philos Trans R Soc Lond B Biol Sci. 2000 Jan 29;355(1393):135-46.

415. Spence SA, Liddle PF, Stefan MD, Hellewell JS, Sharma T, Friston KJ, Hirsch SR, Frith CD, Murray RM, Deakin JF, Grasby PM. Functional anatomy of verbal fluency in people with schizophrenia and those atgenetic risk. Focal dysfunction and distributed disconnectivity reappraised. Br J Psychiatry. 2000 Jan;176:52-60.

416. Mechelli A, Friston KJ, Price CJ. The effects of presentation rate during word and pseudoword reading: a comparison of PET and fMRI. J Cogn Neurosci. 2000;12 Suppl 2:145-56.

417. Grootoonk S, Hutton C, Ashburner J, Howseman AM, Josephs O, Rees G, Friston KJ, Turner R. Characterization and correction of interpolation effects in the realignment of fMRI time series. Neuroimage. 2000 Jan;11(1):49-57.

418. Buchel C, Dolan RJ, Armony JL, Friston KJ. Amygdala-hippocampal involvement in human aversive trace conditioning revealed through event-related functional magnetic resonance imaging. J Neurosci. 1999 Dec 15;19(24):10869-76.

419. Kiebel SJ, Poline JB, Friston KJ, Holmes AP, Worsley KJ. Robust smoothness estimation in statistical parametric maps using standardized residuals from the general linear model. Neuroimage. 1999 Dec;10(6):756-66.

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420. Coull JT, Buchel C, Friston KJ, Frith CD. Noradrenergically mediated plasticity in a human attentional neuronal network. Neuroimage. 1999 Dec;10(6):705-15. Erratum in: Neuroimage 2000 Jun;11(6 Pt 1):822.

421. Friston KJ, Zarahn E, Josephs O, Henson RN, Dale AM. Stochastic designs in event-related fMRI. Neuroimage. 1999 Nov;10(5):607-19.

422. Friston KJ, Holmes AP, Price CJ, Buchel C, Worsley KJ. Multisubject fMRI studies and conjunction analyses. Neuroimage. 1999 Oct;10(4):385-96.

423. Rakshi JS, Uema T, Ito K, Bailey DL, Morrish PK, Ashburner J, Dagher A, Jenkins IH, Friston KJ, Brooks DJ. Frontal, midbrain and striatal dopaminergic function in early and advanced Parkinson's disease A 3D [(18)F]dopa-PET study. Brain. 1999 Sep;122 ( Pt 9):1637-50.

424. Chawla D, Lumer ED, Friston KJ. The relationship between synchronization among neuronal populations and their mean activity levels. Neural Comput. 1999 Aug 15;11(6):1389-411.

425. Morris JS, Smith KA, Cowen PJ, Friston KJ, Dolan RJ. Covariation of activity in habenula and dorsal raphe nuclei following tryptophan depletion. Neuroimage. 1999 Aug;10(2):163-72.

426. Price CJ, Mummery CJ, Moore CJ, Frakowiak RS, Friston KJ. Delineating necessary and sufficient neural systems with functional imaging studies of neuropsychological patients. J Cogn Neurosci. 1999 Jul;11(4):371-82.

427. May A, Ashburner J, Buchel C, McGonigle DJ, Friston KJ, Frackowiak RS, Goadsby PJ. Correlation between structural and functional changes in brain in an idiopathic headache syndrome. Nat Med. 1999 Jul;5(7):836- 8.

428. Chawla D, Rees G, Friston KJ. The physiological basis of attentional modulation in extrastriate visual areas. Nat Neurosci. 1999 Jul;2(7):671-6.

429. Price CJ, Veltman DJ, Ashburner J, Josephs O, Friston KJ. The critical relationship between the timing of stimulus presentation and data acquisition in blocked designs with fMRI. Neuroimage. 1999 Jul;10(1):36- 44.

430. Friston KJ, Holmes AP, Worsley KJ. How many subjects constitute a study? Neuroimage. 1999 Jul;10(1):1-5.

431. Abell F, Krams M, Ashburner J, Passingham R, Friston K, Frackowiak R, Happe F, Frith C, Frith U. The neuroanatomy of autism: a voxel-based whole brain analysis of structural scans. Neuroreport. 1999 Jun 3;10(8):1647-51.

432. Smith KA, Morris JS, Friston KJ, Cowen PJ, Dolan RJ. Brain mechanisms associated with depressive relapse and associated cognitive impairment following acute tryptophan depletion. Br J Psychiatry. 1999 Jun;174:525-9.

433. Wright IC, Sharma T, Ellison ZR, McGuire PK, Friston KJ, Brammer MJ, Murray RM, Bullmore ET. Supra-regional brain systems and the neuropathology of schizophrenia. Cereb Cortex. 1999 Jun;9(4):366-78.

434. Ito K, Morrish PK, Rakshi JS, Uema T, Ashburner J, Bailey DL, Friston KJ, Brooks DJ. Statistical parametric mapping with 18F-dopa PET shows bilaterally reduced striatal and nigral dopaminergic function in early Parkinson's disease. J Neurol Neurosurg Psychiatry. 1999 Jun;66(6):754-8.

435. Ashburner J, Andersson JL, Friston KJ. High-dimensional image registration using symmetric priors. Neuroimage. 1999 Jun;9(6 Pt 1):619-28.

436. Chawla D, Buechel C, Edwards R, Howseman A, Josephs O, Ashburner J, Friston KJ. Speed-dependent responses in V5: A replication study. Neuroimage. 1999 May;9(5):508-15.

437. Strange BA, Fletcher PC, Henson RN, Friston KJ, Dolan RJ. Segregating the functions of human hippocampus. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):4034-9.

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438. Krams M, Quinton R, Ashburner J, Friston KJ, Frackowiak RS, Bouloux PM, Passingham RE. Kallmann's syndrome: mirror movements associated with bilateral corticospinal tract hypertrophy. Neurology. 1999 Mar 10;52(4):816-22.

439. Buchel C, Coull JT, Friston KJ. The predictive value of changes in effective connectivity for human learning. Science. 1999 Mar 5;283(5407):1538-41.

440. Fletcher P, Buchel C, Josephs O, Friston K, Dolan R. Learning-related neuronal responses in prefrontal cortex studied with functional neuroimaging. Cereb Cortex. 1999 Mar;9(2):168-78.

441. Sell LA, Morris J, Bearn J, Frackowiak RS, Friston KJ, Dolan RJ. Activation of reward circuitry in human opiate addicts. Eur J Neurosci. 1999 Mar;11(3):1042-8.

442. Fletcher P, McKenna PJ, Friston KJ, Frith CD, Dolan RJ. Abnormal cingulate modulation of fronto-temporal connectivity in schizophrenia. Neuroimage. 1999 Mar;9(3):337-42.

443. Friston KJ Modularity, segregation & interactions. Behavioral and Brain Sciences Feb 1999 Vol 22 No 1

444. Wright IC, Ellison ZR, Sharma T, Friston KJ, Murray RM, McGuire PK. Mapping of grey matter changes in schizophrenia. Schizophr Res. 1999 Jan 4;35(1):1-14.

445. Friston KJ. Schizophrenia and the disconnection hypothesis. Acta Psychiatr Scand Suppl. 1999;395:68-79.

446. Dolan RJ, Fletcher PC, McKenna P, Friston KJ, Frith CD. Abnormal neural integration related to cognition in schizophrenia. Acta Psychiatr Scand Suppl. 1999;395:58-67.

447. Toni I, Schluter ND, Josephs O, Friston K, Passingham RE. Signal-, set- and movement-related activity in the human brain: an event-related fMRI study. Cereb Cortex. 1999 Jan-Feb;9(1):35-49.

448. Price CJ, Friston KJ. Scanning patients with tasks they can perform. Hum Brain Mapp. 1999;8(2-3):102-8.

449. Friston K, Phillips J, Chawla D, Buchel C. Revealing interactions among brain systems with nonlinear PCA. Hum Brain Mapp. 1999;8(2-3):92-7.

450. Ashburner J, Friston KJ. Nonlinear spatial normalization using basis functions. Hum Brain Mapp. 1999;7(4):254-66.

451. Signorini M, Paulesu E, Friston K, Perani D, Colleluori A, Lucignani G, Grassi F, Bettinardi V, Frackowiak RS, Fazio F. Rapid assessment of regional cerebral metabolic abnormalities in single subjects with quantitative and nonquantitative [18F]FDG PET: A clinical validation of statistical parametric mapping. Neuroimage. 1999 Jan;9(1):63-80.

452. Samuel M, Williams SC, Leigh PN, Simmons A, Chakraborti S, Andrew CM, Friston KJ, Goldstein LH, Brooks DJ. Exploring the temporal nature of hemodynamic responses of cortical motor areas using functional MRI. Neurology. 1998 Dec;51(6):1567-75.

453. Fletcher PC, McKenna PJ, Frith CD, Grasby PM, Friston KJ, Dolan RJ. Brain activations in schizophrenia during a graded memory task studied with functional neuroimaging. Arch Gen Psychiatry. 1998 Nov;55(11):1001-8.

454. Turner R, Howseman A, Rees GE, Josephs O, Friston K. Functional magnetic resonance imaging of the human brain: data acquisition and analysis. Exp Brain Res. 1998 Nov;123(1-2):5-12.

455. Vargha-Khadem F, Watkins KE, Price CJ, Ashburner J, Alcock KJ, Connelly A, Frackowiak RS, Friston KJ, Pembrey ME, Mishkin M, Gadian DG, Passingham RE. Neural basis of an inherited speech and language disorder. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12695-700.

135

456. Buchel C, Holmes AP, Rees G, Friston KJ. Characterizing stimulus-response functions using nonlinear regressors in parametric fMRI experiments. Neuroimage. 1998 Aug;8(2):140-8.

457. Buchel C, Price C, Friston K. A multimodal language region in the ventral visual pathway. Nature. 1998 Jul 16;394(6690):274-7.

458. Buchel C, Josephs O, Rees G, Turner R, Frith CD, Friston KJ. The functional anatomy of attention to visual motion. A functional MRI study. Brain. 1998 Jul;121 ( Pt 7):1281-94.

459. Acton PD, Friston KJ. Statistical parametric mapping in functional neuroimaging: beyond PET and fMRI activation studies. Eur J Nucl Med. 1998 Jul;25(7):663-7.

460. Lumer ED, Friston KJ, Rees G. Neural correlates of perceptual rivalry in the human brain. Science. 1998 Jun 19;280(5371):1930-4.

461. Frith C, Rees G, Friston K. Psychosis and the experience of self. Brain systems underlying self-monitoring. Ann N Y Acad Sci. 1998 May 15;843:170-8.

462. Price CJ, Howard D, Patterson K, Warburton EA, Friston KJ, Frackowiak SJ. A functional neuroimaging description of two deep dyslexic patients. J Cogn Neurosci. 1998 May;10(3):303-15.

463. Buchel C, Morris J, Dolan RJ, Friston KJ. Brain systems mediating aversive conditioning: an event-related fMRI study. Neuron. 1998 May;20(5):947-57.

464. Morris JS, Friston KJ, Dolan RJ. Experience-dependent modulation of tonotopic neural responses in human auditory cortex. Proc Biol Sci. 1998 Apr 22;265(1397):649-57.

465. Friston KJ. The disconnection hypothesis. Schizophr Res. 1998 Mar 10;30(2):115-25.

466. Buchel C, Price C, Frackowiak RS, Friston K. Different activation patterns in the visual cortex of late and congenitally blind subjects. Brain. 1998 Mar;121 ( Pt 3):409-19.

467. Friston KJ. Imaging neuroscience: principles or maps? Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):796-802.

468. Boecker H, Dagher A, Ceballos-Baumann AO, Passingham RE, Samuel M, Friston KJ, Poline J, Dettmers C, Conrad B, Brooks DJ. Role of the human rostral supplementary motor area and the basal ganglia inmotor sequence control: investigations with H2 15O PET. J Neurophysiol. 1998 Feb;79(2):1070-80.

469. Chawla D, Phillips J, Buechel C, Edwards R, Friston KJ. Speed-dependent motion-sensitive responses in V5: an fMRI study. Neuroimage. 1998 Feb;7(2):86-96.

470. Friston KJ Modes or models: a critique on independent component analysis for fMRI. Trends in Cognitive Sciences 1998; 2:373-374

471. Morris JS, Friston KJ, Buchel C, Frith CD, Young AW, Calder AJ, Dolan RJ. A neuromodulatory role for the human amygdala in processing emotional facial expressions. Brain. 1998 Jan;121 ( Pt 1):47-57.

472. Buchel C, Friston KJ. Dynamic changes in effective connectivity characterized by variable parameter regression and Kalman filtering. Hum Brain Mapp. 1998;6(5-6):403-8.

473. Ashburner J, Hutton C, Frackowiak R, Johnsrude I, Price C, Friston K. Identifying global anatomical differences: deformation-based morphometry. Hum Brain Mapp. 1998;6(5-6):348-57.

474. Friston KJ, Josephs O, Rees G, Turner R. Nonlinear event-related responses in fMRI. Magn Reson Med. 1998 Jan;39(1):41-52.

136

475. Friston KJ, Fletcher P, Josephs O, Holmes A, Rugg MD, Turner R. Event-related fMRI: characterizing differential responses. Neuroimage. 1998 Jan;7(1):30-40.

476. Price CJ, Friston KJ. The temporal dynamics of reading: a PET study. Proc Biol Sci. 1997 Dec 22;264(1389):1785-91.

477. Buchel C, Friston KJ. Modulation of connectivity in visual pathways by attention: cortical interactions evaluated with structural equation modelling and fMRI. Cereb Cortex. 1997 Dec;7(8):768-78.

478. Richardson MP, Friston KJ, Sisodiya SM, Koepp MJ, Ashburner J, Free SL, Brooks DJ, Duncan JS. Cortical grey matter and benzodiazepine receptors in malformations of cortical development. A voxel-based comparison of structural and functional imaging data. Brain. 1997 Nov;120 ( Pt 11):1961-73.

479. Buchel C, Turner R, Friston K. Lateral geniculate activations can be detected using intersubject averaging and fMRI. Magn Reson Med. 1997 Nov;38(5):691-4.

480. Ashburner J, Neelin P, Collins DL, Evans A, Friston K. Incorporating prior knowledge into image registration Neuroimage. 1997 Nov;6(4):344-52.

481. Worsley KJ, Poline JB, Friston KJ, Evans AC. Characterizing the response of PET and fMRI data using multivariate linear models. Neuroimage. 1997 Nov;6(4):305-19.

482. Rees G, Howseman A, Josephs O, Frith CD, Friston KJ, Frackowiak RS, Turner R. Characterizing the relationship between BOLD contrast and regional cerebral blood flow measurements by varying the stimulus presentation rate. Neuroimage. 1997 Nov;6(4):270-8.

483. Dolan RJ, Friston KJ. Functional imaging and neuropsychiatry. Psychol Med. 1997 Nov;27(6):1241-6.

484. Dolan RJ, Fink GR, Rolls E, Booth M, Holmes A, Frackowiak RS, Friston KJ. How the brain learns to see objects and faces in an impoverished context. Nature. 1997 Oct 9;389(6651):596-9.

485. Friston KJ, Buechel C, Fink GR, Morris J, Rolls E, Dolan RJ. Psychophysiological and modulatory interactions in neuroimaging. Neuroimage. 1997 Oct;6(3):218-29.

486. Ashburner J, Friston K. Multimodal image coregistration and partitioning--a unified framework. Neuroimage. 1997 Oct;6(3):209-17.

487. Reiman EM, Lane RD, Ahern GL, Schwartz GE, Davidson RJ, Friston KJ, Yun LS, Chen K. Neuroanatomical correlates of externally and internally generated human emotion. Am J Psychiatry. 1997 Jul;154(7):918-25.

488. Friston KJ Stephan KM Frackowiak RSJ Transient phase-locking and dynamic correlations: Are they the same thing? Human Brain Mapping 1997;5:48-57

489. Morris JS, Friston KJ, Dolan RJ. Neural responses to salient visual stimuli. Proc Biol Sci. 1997 May 22;264(1382):769-75.

490. Griffiths TD Jackson MC Spillane JA Friston KJ Frackowiak RSJ A neural substrate for musical hallucinosis NeuroCase 1997;3:167-172

491. Chua SE, Wright IC, Poline JB, Liddle PF, Murray RM, Frackowiak RS, Friston KJ, McGuire PK. Grey matter correlates of syndromes in schizophrenia. A semi-automated analysis of structural magnetic resonance images. Br J Psychiatry. 1997 May;170:406-10.

492. Kiebel SJ, Ashburner J, Poline JB, Friston KJ. MRI and PET coregistration--a cross validation of statistical parametric mapping and automated image registration. Neuroimage. 1997 May;5(4 Pt 1):271-9.

137

493. Price CJ, Friston KJ. Cognitive conjunction: a new approach to brain activation experiments. Neuroimage. 1997 May;5(4 Pt 1):261-70.

494. Friston KJ. Another neural code? Neuroimage. 1997 Apr;5(3):213-20.

495. Friston KJ. Transients, metastability, and neuronal dynamics. Neuroimage. 1997 Feb;5(2):164-71.

496. Poline JB, Worsley KJ, Evans AC, Friston KJ. Combining spatial extent and peak intensity to test for activations in functional imaging. Neuroimage. 1997 Feb;5(2):83-96.

497. Price CJ Moore CJ Friston KJ Subtractions conjunctions and interactions in experimental design of activation studies Human Brain Mapping 1997;5:264-272

498. Friston KJ. Testing for anatomically specified regional effects. Hum Brain Mapp. 1997;5(2):133-6.

499. Josephs O Turner R Friston KJ Event-related fMRI. Human Brain Mapping 1997;5:243-248

500. Friston KJ, Malizia AL, Wilson S, Cunningham VJ, Jones T, Nutt DJ. Analysis of dynamic radioligand displacement or "activation" studies. J Cereb Blood Flow Metab. 1997 Jan;17(1):80-93.

501. Friston KJ, Holmes A, Poline JB, Price CJ, Frith CD. Detecting activations in PET and fMRI: levels of inference and power. Neuroimage. 1996 Dec;4(3 Pt 1):223-35.

502. Frith CD, Friston KJ. The role of the thalamus in "top down" modulation of attention to sound. Neuroimage. 1996 Dec;4(3 Pt 1):210-5.

503. Dettmers C, Connelly A, Stephan KM, Turner R, Friston KJ, Frackowiak RS, Gadian DG. Quantitative comparison of functional magnetic resonance imaging with positron emission tomography using a force- related paradigm. Neuroimage. 1996 Dec;4(3 Pt 1):201-9.

504. Price CJ, Moore CJ, Humphreys GW, Frackowiak RS, Friston KJ. The neural regions sustaining object recognition and naming. Proc Biol Sci. 1996 Nov 22;263(1376):1501-7.

505. Frackowiak RS, Zeki S, Poline JB, Friston KJ. A critique of a new analysis proposed for functional neuroimaging. Eur J Neurosci. 1996 Nov;8(11):2229-31.

506. Fletcher PC, Frith CD, Grasby PM, Friston KJ, Dolan RJ. Local and distributed effects of apomorphine on fronto- temporal function in acute unmedicated schizophrenia. J Neurosci. 1996 Nov 1;16(21):7055-62.

507. Koepp MJ, Richardson MP, Brooks DJ, Poline JB, Van Paesschen W, Friston KJ, Duncan JS. Cerebral benzodiazepine receptors in hippocampal sclerosis. An objective in vivo analysis. Brain. 1996 Oct;119 ( Pt 5):1677-87.

508. Friston KJ, Price CJ, Fletcher P, Moore C, Frackowiak RS, Dolan RJ. The trouble with cognitive subtraction. Neuroimage. 1996 Oct;4(2):97-104.

509. Buchel C, Wise RJ, Mummery CJ, Poline JB, Friston KJ. Nonlinear regression in parametric activation studies. Neuroimage. 1996 Aug;4(1):60-6.

510. Poline JB, Vandenberghe R, Holmes AP, Friston KJ, Frackowiak RS. Reproducibility of PET activation studies: lessons from a multi-center European experiment. EU concerted action on functional imaging. Neuroimage. 1996 Aug;4(1):34-54.

511. Friston KJ. Theoretical neurobiology and schizophrenia. Br Med Bull. 1996 Jul;52(3):644-55.

512. Price CJ, Wise RJ, Warburton EA, Moore CJ, Howard D, Patterson K, Frackowiak RS, Friston KJ. Hearing and saying. The functional neuro-anatomy of auditory word processing. Brain. 1996 Jun;119 ( Pt 3):919-31.

138

513. Friston KJ Poline J-B Holmes AP Frith CD Frackowiak RSJ A multivariate analysis of PET activation studies Human Brain Mapping 1996;4:140-151

514. Fletcher PC, Dolan RJ, Shallice T, Frith CD, Frackowiak RS, Friston KJ. Is multivariate analysis of PET data more revealing than the univariate approach? Evidence from a study of episodic memory retrieval. Neuroimage. 1996 Jun;3(3 Pt 1):209-15.

515. Worsley KJ Marrett S Neelin P Vandal AC Friston KJ Evans AC A unified statistical approach for determining significant signals in images of cerebral activation Human Brain Mapping 1996;4:58-73

516. Friston KJ, Stephan KM, Heather JD, Frith CD, Ioannides AA, Liu LC, Rugg MD, Vieth J, Keber H, Hunter K, Frackowiak RS. A multivariate analysis of evoked responses in EEG and MEG data. Neuroimage. 1996 Jun;3(3 Pt 1):167-74.

517. Friston KJ, Frith CD, Fletcher P, Liddle PF, Frackowiak RS. Functional topography: multidimensional scaling and functional connectivity in the brain. Cereb Cortex. 1996 Mar-Apr;6(2):156-64.

518. Friston KJ, Williams S, Howard R, Frackowiak RS, Turner R. Movement-related effects in fMRI time-series. Magn Reson Med. 1996 Mar;35(3):346-55.

519. Wright IC, McGuire PK, Poline JB, Travere JM, Murray RM, Frith CD, Frackowiak RS, Friston KJ. A voxel-based method for the statistical analysis of gray and white matter density applied to schizophrenia. Neuroimage. 1995 Dec;2(4):244-52.

520. Frith CD Kapur N Friston KJ Liddle PF and Frackowiak RSJ Regional cerebral activity associated with the incidental processing of pseudo words Human Brain Mapping 1995; 3:153-160

521. Friston KJ Regulation of rCBF by diffusable signals: An analysis of constraints on diffusion and elimination Human Brain Mapping 1995; 3:56-65

522. Dolan RJ, Fletcher P, Frith CD, Friston KJ, Frackowiak RS, Grasby PM. Dopaminergic modulation of impaired cognitive activation in the anterior cingulate cortex in schizophrenia. Nature. 1995 Nov 9;378(6553):180-2.

523. Friston KJ. Neuronal transients. Proc Biol Sci. 1995 Sep 22;261(1362):401-5.

524. Friston KJ Ungerleider LG Jezzard P and Turner R Characterizing modulatory interactions between areas V1 and V2 in human cortex: A new treatment of functional MRI data Human Brain Mapping 1995;2;211-224

525. Frith CD, Friston KJ, Herold S, Silbersweig D, Fletcher P, Cahill C, Dolan RJ, Frackowiak RS, Liddle PF. Regional brain activity in chronic schizophrenic patients during the performance of a verbal fluency task. Br J Psychiatry. 1995 Sep;167(3):343-9.

526. Poline JB, Worsley KJ, Holmes AP, Frackowiak RS, Friston KJ. Estimating smoothness in statistical parametric maps: variability of p values. J Comput Assist Tomogr. 1995 Sep-Oct;19(5):788-96.

527. Worsley KJ, Poline JB, Vandal AC, Friston KJ. Tests for distributed, nonfocal brain activations. Neuroimage. 1995 Sep;2(3):183-94.

528. Worsley KJ, Friston KJ. Analysis of fMRI time-series revisited--again. Neuroimage. 1995 Sep;2(3):173-81.

529. Friston KJ, Frith CD, Frackowiak RS, Turner R. Characterizing dynamic brain responses with fMRI: a multivariate approach. Neuroimage. 1995 Jun;2(2):166-72.

530. Friston KJ, Frith CD, Turner R, Frackowiak RS. Characterizing evoked hemodynamics with fMRI. Neuroimage. 1995 Jun;2(2):157-65.

139

531. Friston KJ. Commentary and opinion: II. Statistical parametric mapping: ontology and current issues. J Cereb Blood Flow Metab. 1995 May;15(3):361-70.

532. Paulesu E, Connelly A, Frith CD, Friston KJ, Heather J, Myers R, Gadian DG, Frackowiak RS. Functional MR imaging correlations with positron emission tomography. Initial experience using a cognitive activation paradigm on verbal working memory. Neuroimaging Clin N Am. 1995 May;5(2):207-25.

533. Friston KJ Functional and effective connectivity in neuroimaging: A synthesis Human Brain Mapping 1995: 2;56-78

534. Kapur N, Friston KJ, Young A, Frith CD, Frackowiak RS. Activation of human hippocampal formation during memory for faces: a PET study. Cortex. 1995 Mar;31(1):99-108.

535. Friston KJ, Holmes AP, Poline JB, Grasby PJ, Williams SC, Frackowiak RS, Turner R. Analysis of fMRI time-series revisited. Neuroimage. 1995 Mar;2(1):45-53.

536. Friston KJ, Frith CD. Schizophrenia: a disconnection syndrome? Clin Neurosci. 1995;3(2):89-97.

537. Friston KJ Holmes AP Worsley KJ Poline JB Frith CD and Frackowiak RSJ Statistical Parametric Maps in functional imaging: A general linear approach Human Brain Mapping 1995;2;189-210

538. Friston KJ Ashburner J Frith CD Poline J-B Heather JD and Frackowiak RSJ The spatial registration and normalisation of images Human Brain Mapping 1995;3:165-189

539. Grasby PM, Frith CD, Paulesu E, Friston KJ, Frackowiak RS, Dolan RJ. The effect of the muscarinic antagonist scopolamine on regional cerebral blood flow during the performance of a memory task. Exp Brain Res. 1995;104(2):337-48.

540. Friston KJ Worsley KJ Frackowiak RSJ Mazziotta JC & Evans AC Assessing the significance of focal activations using their spatial extent Human Brain Mapping 1994;1:214-220

541. Grasby PM, Frith CD, Friston KJ, Simpson J, Fletcher PC, Frackowiak RS, Dolan RJ. A graded task approach to the functional mapping of brain areas implicated in auditory-verbal memory. Brain. 1994 Dec;117 ( Pt 6):1271-82.

542. Friston KJ Jezzard PJ and Turner R Analysis of functional MRI time-series Human Brain Mapping 1994; 1:153- 171

543. Derbyshire SW, Jones AK, Devani P, Friston KJ, Feinmann C, Harris M, Pearce S, Watson JD, Frackowiak RS. Cerebral responses to pain in patients with atypical facial pain measured by positron emission tomography. J Neurol Neurosurg Psychiatry. 1994 Oct;57(10):1166-72.

544. Frackowiak RS, Friston KJ. Functional neuroanatomy of the human brain: positron emission tomography--a new neuroanatomical technique. J Anat. 1994 Apr;184 ( Pt 2):211-25.

545. Friston KJ, Tononi G, Reeke GN Jr, Sporns O, Edelman GM. Value-dependent selection in the brain: simulation in a synthetic neural model. Neuroscience. 1994 Mar;59(2):229-43.

546. Grasby PM, Frith CD, Friston K, Frackowiak RS, Dolan RJ. Activation of the human hippocampal formation during auditory-verbal long-term memory function. Neurosci Lett. 1993 Dec 12;163(2):185-8.

547. Dolan RJ, Bench CJ, Liddle PF, Friston KJ, Frith CD, Grasby PM, Frackowiak RS. Dorsolateral prefrontal cortex dysfunction in the major psychoses; symptom or disease specificity? J Neurol Neurosurg Psychiatry. 1993 Dec;56(12):1290-4.

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548. Ramsay SC, Murphy K, Shea SA, Friston KJ, Lammertsma AA, Clark JC, Adams L, Guz A, Frackowiak RS. Changes in global cerebral blood flow in humans: effect on regional cerebral blood flow during a neural activation task. J Physiol. 1993 Nov;471:521-34.

549. Friston KJ, Frith CD, Frackowiak RS. Principal component analysis learning algorithms: a neurobiological analysis. Proc Biol Sci. 1993 Oct 22;254(1339):47-54.

550. Bench CJ, Frith CD, Grasby PM, Friston KJ, Paulesu E, Frackowiak RS, Dolan RJ. Investigations of the functional anatomy of attention using the Stroop test. Neuropsychologia. 1993 Sep;31(9):907-22.

551. Friston KJ Frith CD and Frackowiak RSJ Time-dependent changes in effective connectivity measured with PET Human Brain Mapping 1993; 1:69-79

552. Grasby PM, Friston KJ, Bench CJ, Cowen PJ, Frith CD, Liddle PF, Frackowiak RS, Dolan RJ. The effect of the dopamine agonist, apomorphine, on regional cerebral blood flow in normal volunteers. Psychol Med. 1993 Aug;23(3):605-12.

553. Bench CJ, Friston KJ, Brown RG, Frackowiak RS, Dolan RJ. Regional cerebral blood flow in depression measured by positron emission tomography: the relationship with clinical dimensions. Psychol Med. 1993 Aug;23(3):579-90.

554. Weiller C, Ramsay SC, Wise RJ, Friston KJ, Frackowiak RS. Individual patterns of functional reorganization in the human cerebral cortex after capsular infarction. Ann Neurol. 1993 Feb;33(2):181-9.

555. Deiber MP, Pollak P, Passingham R, Landais P, Gervason C, Cinotti L, Friston K, Frackowiak R, Mauguiere F, Benabid AL. Thalamic stimulation and suppression of parkinsonian tremor. Evidence of a cerebellar deactivation using positron emission tomography. Brain. 1993 Feb;116 ( Pt 1):267-79.

556. Grasby PM, Frith CD, Friston KJ, Bench C, Frackowiak RS, Dolan RJ. Functional mapping of brain areas implicated in auditory--verbal memory function. Brain. 1993 Feb;116 ( Pt 1):1-20.

557. Friston KJ, Frith CD, Liddle PF, Frackowiak RS. Functional connectivity: the principal-component analysis of large (PET) data sets. J Cereb Blood Flow Metab. 1993 Jan;13(1):5-14.

558. Howard D, Patterson K, Wise R, Brown WD, Friston K, Weiller C, Frackowiak R. The cortical localization of the lexicons. Positron emission tomography evidence. Brain. 1992 Dec;115 ( Pt 6):1769-82.

559. Price C, Wise R, Ramsay S, Friston K, Howard D, Patterson K, Frackowiak R. Regional response differences within the human auditory cortex when listening to words. Neurosci Lett. 1992 Nov 9;146(2):179-82.

560. Dolan RJ, Bench CJ, Brown RG, Scott LC, Friston KJ, Frackowiak RS. Regional cerebral blood flow abnormalities in depressed patients with cognitive impairment. J Neurol Neurosurg Psychiatry. 1992 Sep;55(9):768-73.

561. Bench CJ, Friston KJ, Brown RG, Scott LC, Frackowiak RS, Dolan RJ. The anatomy of melancholia--focal abnormalities of cerebral blood flow in major depression. Psychol Med. 1992 Aug;22(3):607-15.

562. Friston KJ, Grasby PM, Bench CJ, Frith CD, Cowen PJ, Liddle PF, Frackowiak RS, Dolan R. Measuring the neuromodulatory effects of drugs in man with positron emission tomography. Neurosci Lett. 1992 Jul 6;141(1):106-10.

563. Grafton ST, Mazziotta JC, Presty S, Friston KJ, Frackowiak RS, Phelps ME. Functional anatomy of human procedural learning determined with regional cerebral blood flow and PET. J Neurosci. 1992 Jul;12(7):2542- 8.

564. Friston KJ, Frith CD, Passingham RE, Liddle PF, Frackowiak RS. Motor practice and neurophysiological adaptation in the cerebellum: a positron tomography study. Proc Biol Sci. 1992 Jun 22;248(1323):223-8.

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565. Weiller C, Chollet F, Friston KJ, Wise RJ, Frackowiak RS. Functional reorganization of the brain in recovery from striatocapsular infarction in man. Ann Neurol. 1992 May;31(5):463-72.

566. Friston KJ, Frith CD, Passingham RE, Dolan RJ, Liddle PF, Frackowiak RS. Entropy and cortical activity: information theory and PET findings. Cereb Cortex. 1992 May-Jun;2(3):259-67.

567. Friston KJ, Liddle PF, Frith CD, Hirsch SR, Frackowiak RS. The left Medial temporal region and schizophrenia. A PET study. Brain. 1992 Apr;115 ( Pt 2):367-82.

568. Liddle PF, Friston KJ, Frith CD, Frackowiak RS. Cerebral blood flow and mental processes in schizophrenia. J R Soc Med. 1992 Apr;85(4):224-7.

569. Frith CD, Friston KJ, Liddle PF, Frackowiak RS. PET imaging and cognition in schizophrenia. J R Soc Med. 1992 Apr;85(4):222-4.

570. Lammertsma AA, Martin AJ, Friston KJ, Jones T. In vivo measurement of the volume of distribution of water in cerebral grey matter: effects on the calculation of regional cerebral blood flow. J Cereb Blood Flow Metab. 1992 Mar;12(2):291-5.

571. Liddle PF, Friston KJ, Frith CD, Hirsch SR, Jones T, Frackowiak RS. Patterns of cerebral blood flow in schizophrenia. Br J Psychiatry. 1992 Feb;160:179-86.

572. Jones AK, Friston K, Frackowiak RS. Localization of responses to pain in human cerebral cortex. Science. 1992 Jan 10;255(5041):215-6.

573. Dolan RJ, Grasby PM, Bench C, Friston KJ, Frith CD. Pharmacological challenge and PET imaging. Clin Neuropharmacol. 1992;15 Suppl 1 Pt A:216A-217A.

574. Grasby PM, Friston KJ, Bench CJ, Frith CD, Paulesu E, Cowen PJ, Liddle PF, Frackowiak RS, Dolan R. The Effect of Apomorphine and Buspirone on Regional Cerebral Blood Flow During the Performance of a Cognitive Task-Measuring Neuromodulatory Effects of Psychotropic Drugs in Man. Eur J Neurosci. 1992;4(12):1203- 1212.

575. Friston KJ. The dorsolateral prefrontal cortex, schizophrenia and PET. J Neural Transm Suppl. 1992;37:79-93.

576. Grasby PM, Friston KJ, Bench C, Cowen PJ, Frith CD, Liddle PF, Frackowiak RS, Dolan RJ. Effect of the 5-HT1A partial agonist buspirone on regional cerebral blood flow in man. Psychopharmacology (Berl). 1992;108(3):380-6.

577. Colebatch JG, Adams L, Murphy K, Martin AJ, Lammertsma AA, Tochon-Danguy HJ, Clark JC, Friston KJ, Guz A. Regional cerebral blood flow during volitional breathing in man. J Physiol. 1991 Nov;443:91-103.

578. Jones AK, Friston KJ, Qi LY, Harris M, Cunningham VJ, Jones T, Feinman C, Frackowiak RS. Sites of action of morphine in the brain. Lancet. 1991 Sep 28;338(8770):825..

579. Wise R, Chollet F, Hadar U, Friston K, Hoffner E, Frackowiak R. Distribution of cortical neural networks involved in word comprehension and word retrieval. Brain. 1991 Aug;114 ( Pt 4):1803-17.

580. Friston KJ, Frith CD, Liddle PF, Frackowiak RS. Comparing functional (PET) images: the assessment of significant change. J Cereb Blood Flow Metab. 1991 Jul;11(4):690-9.

581. Martin AJ, Friston KJ, Colebatch JG, Frackowiak RS. Decreases in regional cerebral blood flow with normal aging. J Cereb Blood Flow Metab. 1991 Jul;11(4):684-9.

582. Friston KJ, Frith CD, Liddle PF, Frackowiak RS. Plastic transformation of PET images. J Comput Assist Tomogr. 1991 Jul-Aug;15(4):634-9.

142

583. Frith CD, Friston K, Liddle PF, Frackowiak RS. Willed action and the prefrontal cortex in man: a study with PET. Proc Biol Sci. 1991 Jun 22;244(1311):241-6.

584. Colebatch JG, Deiber MP, Passingham RE, Friston KJ, Frackowiak RS. Regional cerebral blood flow during voluntary arm and hand movements in human subjects. J Neurophysiol. 1991 Jun;65(6):1392-401.

585. Friston KJ, Frith CD, Liddle PF, Frackowiak RS. Investigating a network model of word generation with positron emission tomography. Proc Biol Sci. 1991 May 22;244(1310):101-6.

586. Jones AK, Brown WD, Friston KJ, Qi LY, Frackowiak RS. Cortical and subcortical localization of response to pain in man using positron emission tomography. Proc Biol Sci. 1991 Apr 22;244(1309):39-44.

587. Jones AK, Friston K, Dolan R. Positron emission tomography as a research tool in the investigation of psychiatric and psychological disorders. Baillieres Clin Endocrinol Metab. 1991 Mar;5(1):187-203.

588. Zeki S, Watson JD, Lueck CJ, Friston KJ, Kennard C, Frackowiak RS. A direct demonstration of functional specialization in human visual cortex. J Neurosci. 1991 Mar;11(3):641-9.

589. Friston KJ, Grasby PM, Frith CD, Bench CJ, Dolan RJ, Cowen PJ, Liddle PF, Frackowiak RS. The neurotransmitter basis of cognition: psychopharmacological activation studies using positron emission tomography. Ciba Found Symp. 1991;163:76-87; discussion 87-92.

590. Friston KJ, Frackowiak RS. Cerebral function in aging and Alzheimer's disease: the role of PET. Electroencephalogr Clin Neurophysiol Suppl. 1991;42:355-65.

591. Deiber MP, Passingham RE, Colebatch JG, Friston KJ, Nixon PD, Frackowiak RS. Cortical areas and the selection of movement: a study with positron emission tomography.Exp Brain Res. 1991;84(2):393-402.

592. Jones AK, Liyi Q, Cunningham VV, Brown DW, Ha-Kawa S, Fujiwara T, Friston K, Silva S, Luthra SK, Jones T. Endogenous opiate response to pain in rheumatoid arthritis and cortical and subcortical response to pain in normal volunteers using positron emission tomography. Int J Clin Pharmacol Res. 1991;11(6):261-6.

593. Frith CD, Friston KJ, Liddle PF, Frackowiak RS. A PET study of word finding. Neuropsychologia. 1991;29(12):1137-48.

594. Cowen PJ, Cohen PR, McCance SL, Friston KJ. 5-HT neuroendocrine responses during psychotropic drug treatment: an investigation of the effects of lithium. J Neurosci Methods. 1990 Sep;34(1-3):201-5.

595. Friston KJ, Frith CD, Liddle PF, Dolan RJ, Lammertsma AA, Frackowiak RS. The relationship between global and local changes in PET scans. J Cereb Blood Flow Metab. 1990 Jul;10(4):458-66.

596. Bench CJ, Dolan RJ, Friston KJ, Frackowiak RS. Positron emission tomography in the study of brain metabolism in psychiatric and neuropsychiatric disorders. Br J Psychiatry Suppl. 1990;(9):82-95.

597. Dolan RJ, Friston KJ. Positron emission tomography in psychiatric and neuropsychiatric disorders. Semin Neurol. 1989 Dec;9(4):330-7.

598. Friston KJ, Passingham RE, Nutt JG, Heather JD, Sawle GV, Frackowiak RS. Localisation in PET images: direct fitting of the intercommissural (AC-PC) line. J Cereb Blood Flow Metab. 1989 Oct;9(5):690-5.

599. Lueck CJ, Zeki S, Friston KJ, Deiber MP, Cope P, Cunningham VJ, Lammertsma AA, Kennard C, Frackowiak RS. The colour centre in the cerebral cortex of man. Nature. 1989 Aug 3;340(6232):386-9.

600. Friston KJ, Sharpley AL, Solomon RA, Cowen PJ. Lithium increases slow wave sleep: possible mediation by brain 5-HT2 receptors? Psychopharmacology (Berl). 1989;98(1):139-40.

143

I keep no record of Book Chapters, Conference proceedings, Abstracts, Reviews or Invited Lectures

144 Chris Frith FRS FmedSci FBA

Although I retired from my position at the Wellcome Centre for Neuroimaging at UCL in 2007, I am continuing to develop the new discipline of neural hermeneutics. This discipline concerns the neural basis of social interaction. I am fortunate in having a number of excellent collaborators for this enterprise, in particular, Uta Frith. In October 2011 I was elected a two-year fellow of All-Souls where I organised a series of seminars on Meta-cognition in order to explore the critical role of this process in sharing experiences. My main experimental work is currently performed in the interacting minds centre at Aarhus University. We are trying to delineate the mechanisms underlying this human ability to share representations of the world for it is this ability that makes communication possible.

We think that there are two major processes involved. The first is an automatic form of priming (sometimes referred to as contagion or empathy), whereby our representations of the world become aligned with those of the person with whom we are interacting. The second is a form of forward modelling, analogous to that used in the control of our own actions. Such generative Bayesian models enable us to predict the actions of others and use prediction errors to correct and refine our representations of the mental states of the person we are interacting with.

We are carrying out behavioural and brain imaging experiments that will delineate the neural mechanisms that underlie these two processes in healthy volunteers.

The results will be relevant for our understanding of psychiatric disorders such as schizophrenia. One characteristic of the mistaken perceptions (hallucinations) and beliefs (delusions) associated with this disorder is their resistance to change in spite of their incompatibility with the beliefs and perceptions of others. This indicates a failure in the mechanism by which we align our representations of the world with those of others. Delineating the normal mechanisms of alignment will help us to identify the neural basis of hallucinations and delusions.

Directly emerging from these studies of interacting minds I have become increasingly interested in the role of culture: How it creates us and how we create it. I have been thinking about the role of culture in our experience of volition and responsibility. You can read about this in my essay in honour of Marc Jeannerod. I have also been thinking (again) about the problem of the top, in top-down control. There is no top within the individual person. We are all part of much bigger loops by which culture (other people) exerts top-down control on us while we in turn attempt to influence others. You can read about this in my recent essay on How the brain creates culture.

145 Nikolaus Kriegeskorte, PhD, Programme-Leader Track Medical Research Council Cognition and Brain Sciences Unit 15 Chaucer Road, Cambridge, CB2 7EF, UK [email protected] Work phone: +44-1223-273 791 Cell phone: +44-7 540 356 478

Organization for Human Brain Mapping (OHBM) 5841 Cedar Lake Road, Suite 204 Minneapolis, MN 55416 USA Phone: 1 952-646-2029 | Fax: 1 952-545-6073

14 March 2014

Nomination of Prof Rainer Goebel for the OHBM Glass Brain Award

Dear members of the OHBM Glass Brain Award selection committee,

I would like to nominate Prof Rainer Goebel for the OHBM Glass Brain Award. Rainer has been a formative force in the field of human brain mapping. His contributions range from methodology and tools for visualisation and statistical analysis of neuroimaging data to novel insights on brain function, and on to applications of neuroimaging technology for medicine.

Rainer is a powerhouse of inspiration and motivation to everyone around him. His software package BrainVoyager has enabled scientists to interact with and explore their complex neuroimaging data sets at an unprecedented level. It has also made sophisticated analysis and visualisation techniques accessible to scientists without a background in programming. BrainVoyager is used around the world and has contributed substantially to the growth of neuroimaging-based cognitive neuroscience.

I have known Rainer since 1998 and joined his team at the Max-Planck-Institute in Frankfurt in 1999 as a PhD student. His work inspired me personally to use fMRI to address questions in the field of vision. As his student and personal friend, I may not be entirely unbiased in my estimation of Rainer’s contribution. This nomination therefore includes seven letters of support from prominent scientists in our field: Prof Elia Formisano, Prof David Linden, Prof Nikos Logothetis, Prof Lars Muckli, Prof Kamil Ugurbil, Prof Brain Wandell, and Prof Nikolaus Weiskopf. Some of them are his students and collaborators, but others (Logothetis, Ugurbil, Wandell) are independent voices and major senior figures in our field.

146 Some of Rainer’s major contributions detailed in these letters of support are as follows:

 With an h-index of 69 and over 15K citations (Google Scholar, 14 March 2014), Rainer is a major contributor to the scientific literature.

 He has made wide-ranging contributions to human cognitive and computational neuroscience, including vision, audition, multisensory perception, multistable perception, blindsight, imagery, attention, and higher cognitive function, which have been published in prestigious journals including Nature, Science, Nature Neuroscience, Neuron, PNAS, and Current Biology.

 He is the inventor and lead developer of BrainVoyager, contributing many useful tools to the field including a range of cortical-surface-based analysis and visualisation techniques for fMRI and other neuroimaging modalities.

 He has contributed to multimodal brain imaging analysis techniques, integrating fMRI and scalp electrophysiological measurements, as well as TMS, TDCS, and NIRS.

 He developed software tools for real-time fMRI and fMRI-based neurofeedback and brain-computer interfaces and is also developing medical applications of these tools.

 With his background in mathematical psychology and computational neuroscience (his neural network modelling before the advent of fMRI won him the Heinz-Maier-Leibnitz Advancement Award), he was able to develop neuroimaging analyses as motivated by brain theory.

 He contributed to important conceptual and methodological advances in functional and effective connectivity modelling (ICA, Granger causality) and multivariate pattern analysis.

 He is contributing to the integration of computational models into the analysis of brain activity data via his “common brain space” approach, in which activity in neural network simulations is projected onto cortices of individual subjects, for comparison with neuroimaging data.

 He created a major centre for high-field MRI in Maastricht (including 3T, 7T, and 9.4T scanners), where MRI acquisition and analysis methods are developed in close interaction, applied to fundamental problems in basic brain science, and translated into clinical applications and novel therapies for nervous system disorders.

 Rainer is a major force in pushing the limits of functional and anatomical MRI. In particular, his group is developing high-field fMRI techniques promising columnar and laminar resolution for fMRI.

147  Rainer joined OHBM in its second year (Boston, 1996), has never since missed the conference and has served as Chair of OHBM (2007-2008).

As reflected in the seven letters of support, Rainer is a brilliant, inspiring, and highly motivating scientific leader. Beyond his qualities as a scientist and visionary leader, he is also an exceptionally positive presence and a role model for collaborative spirit in our field. Rainer has inspired his many students and collaborators not only to do great science, but to see beyond our own self-interest and contribute to our field with a wider vision.

For all these reasons, Rainer Goebel – among the many great scientists in our field – is truly exceptionally deserving of the honour of the OHBM Glass Brain Award.

Sincerely yours,

Enclosure

CV for Rainer Goebel

Letters of support

 Prof Elia Formisano

 Prof David Linden

 Prof Nikos Logothetis

 Prof Lars Muckli

 Prof Kamil Ugurbil

 Prof Brain Wandell

 Prof Nikolaus Weiskopf

148 Rainer Goebel PhD Professor of Cognitive Neuroscience PI and Director of the Maastricht Brain Imaging Center

Department of Cognitive Neuroscience Faculty of Psychology & Neuroscience Maastricht University The Netherlands

Netherlands Institute for Neuroscience Team Leader: Neuroimaging and Neuromodeling Group Amsterdam The Netherlands

Track record Rainer Goebel’s research career started already as a student where he was working in a grant from the German Science Foundation (DFG) on cognitive modelling investigating whether symbolic or sub-symbolic (connectionist) approaches are better suited to explain how the mind works. In his diploma (master) thesis and in several publications, he applied the symbolic approach (production systems) to model how students learn to write simple computer programs (recursive functions) in the programming languages LOGO and LISP. During his PhD time, Rainer Goebel turned to sub-symbolic (connectionist) modeling performing pioneering work in the domain of vision, integrating cognitive psychology and computer science. His modeling work was rewarded by an invitation to the “Second Connectionist Models Summer School” in San Diego, that also resulted in an influential publication on the binding problem that received the Heinz Maier Leibnitz Advancement award in cognitive science sponsored by the German minister of science and education (1993). In the following years, he unified cognitive theories (Gestalt principles) and modeling with animal neurophysiological data to build one of the first truly biologically inspired neural network models of early-vision that was tested with animal electrophysiological recordings (Nature, 2000). At the same time, Goebel expanded this line of work with research on the human brain by founding the functional neuroimaging group at the Max Planck Institute for Brain Research in Frankfurt/Main in the Dept. of Neurophysiology of Prof. Wolf Singer. His brain imaging (fMRI, MEG) work started with highly cited papers on visual illusions and mental imagery of motion (e.g. Goebel et al., 1998). The studies provided new insights in how the brain processes visual illusions (e.g. illusory contours, apparent motion) and how the brain activates itself during mental imagery. Rainer Goebel continued his functional neuroimaging research at Maastricht University, where he was appointed full professor for Cognitive Neuroscience in the faculty of psychology and neuroscience (2000) and where he founded the Maastricht Brain Imaging Centre (M-BIC, 2005). Goebel’s functional neuroimaging research has led to important discoveries on the neural substrates of unconscious processing in blindsight patients influencing contemporary theories of consciousness (e.g. Tong, 2003; Nature Reviews Neuroscience). His functional neuroimaging research on hallucinations has impacted modern theories of schizophrenia (Neuron, 1999), and his research on visual mental imagery has yielded new views on the role of parietal networks in imagery (Neuron, 2002; Current Opinion in Neurobiology, 2003; Science, 2005). Rainer Goebel’s ideas on visual and motion perception is currently inspiring research in large international networks, including laboratories from the National Institutes of Health in Bethesda, MD, USA; the Max Planck Institute for Brain Research, Frankfurt; University of Glasgow, UK; and Tel Aviv Sourasky Medical Center, Israel. In addition to this core line of research, Rainer’s interest has turned to other sensory and multisensory domains (especially auditory and audio-visual domains), and to higher cognition (with specific interests in object perception and categorization, language and number processing, working memory, and attention). For example, his work on fMRI mental chronometry provided new avenues to reveal the temporal order of activation in different areas during complex cognitive tasks (Neuron, 2002; Current Opinion in Neurobiology, 2003). This work lead also to the development of Granger causality mapping in fMRI (Goebel, 2003), which is now one of the most used effective connectivity methods. In all of these domains integrating cognitive research with new methods, his work is highly influential and is internationally recognized as excellent and innovative. His publications appear consistently in high impact journals, including Nature (1x), Science (3x), PNAS (4x), Neuron (6x), Nature Neuroscience (2x) and Current Biology (6x). The quality of Rainer Goebel’s research stems from his ability to integrate different data acquisition approaches (including the simultaneous acquisition of fMRI, EEG and TMS data) with the development of new data analysis methods. Together with his colleagues, Rainer Goebel invented new data analysis methods that are used worldwide, including brain algorithms for segmentation and alignment of brains, data-driven analysis (cortex-based independent component analysis (ICA), and Granger Causality Mapping (GCM)) and new multivariate classifier tools such as the “searchlight” method (PNAS, 2007) that is now one of the most used multivariate analysis approached in fMRI research. He advanced the integration of multiple research methods (combination fMRI and EEG/MEG; simultaneous measurement of fMRI and TMS; real-time fMRI analysis). Based on real-time fMRI, he recently developed the first hemodynamic communication device for patients with severe motor impairments (Current Biology, 2012) and his translational neuroscience work on fMRI neurofeedback is currently evaluated in clinical trial studies for the treatment of psychological disorders such as depression, Parkinson and phobia. He is open-minded and shares his knowledge and methods when requested by

149 colleagues, such as when he provided advanced analysis methods that were essential for an influential study of genetic influences on brain activity patterns (Science, 2009).

With his recent ERC Advanced Investigators award in 2011, he initiated research with the ultimate goal to crack the neural code for higher cognition. In short, his ambition is to first demonstrate the columnar code for lower-level perception in humans by using high-field fMRI and careful validation in non-human primates. He then aims to use the resulting fMRI approaches to dissect, at a sub-mm scale, the functional units in high-level human brain regions that so far have seen little exploration, and where animal research may contribute little insight. This effort is truly fundamental and will help unearth neural mechanisms underlying high level object vision and categorization, and describe principles that may be applicable in other domains of high-level cognition including consciousness, emotional processing, and language. Rainer Goebel’s current work without a doubt is one of the most visionary ongoing research endeavors in the field of psychology and cognitive neurosciences.

Scientific stature in the Netherlands An international review committee assessed Rainer Goebel’s research division “Cognitive Neuroscience” in 2011; this resulted in the highest rank (all sub-categories judged as “excellent”) of all research sections in 6 psychology faculties in the Netherlands (conducted by Quality Assurance Netherlands Universities, QANU; years 2005 - 2010). His scientific stature is also evident in the generous way in which he shares his expertise to advance cognitive science and set up new research institutions in the Netherlands. He played a crucial advisory role in setting up the FC Donders Center of Neuroimaging at the Radboud University of Nijmegen (NLs). In 2008, Goebel was invited to join the Netherlands Institute for Neuroscience (NIN) of the Royal Academy of Arts and Sciences (KNAW), to share his expertise in (ultra) high field imaging and data modelling with other Dutch research groups. He advised the Dutch ministries of justice and inner affairs on possibilities and limitations of MRI and TMS. He furthermore contributes to the Netherlands Institute for Neuroscience (NIN), Amsterdam, with his own research group on neural computation. In the 2012 evaluation of the NIN by an independent international group of evaluators, his research was judged with the highest rank in all sub-categories. He recently convinced Maastricht University to establish a new imaging center with 3 Tesla, 7 Tesla and 9.4 Tesla scanners for human MRI. These imaging facilities have now been installed and provide Goebel’s research group with one of the most advanced infrastructure for functional MRI research worldwide. Moreover, Rainer Goebel is called upon frequently for his expertise in relevant national committees and networks. He is member of the Nationaal Initiatief Hersenen & Cognitie (NIHC) and of the 3N network. He regularly serves as committee member and reviewers for NWO funding initiatives (e.g. VENI, VIDI, VICI).

International scientific stature Rainer Goebel enjoys unrivalled international reputation. His focus on the synergy between method development and applications is internationally recognized as outstanding. His reputation has led to an extensive track record of national and international collaborations and publications. Moreover, he fulfills important leadership roles. He accepted to become the chair of the Organization for Human Brain Mapping (2006-2009), after being elected by the members of the organization (> 2000). He contributes to the overall quality of the field, through his role as a member of the editorial board of NeuroImage, Frontiers in Brain Imaging Methods, and Social Cognitive & Affective Neuroscience. He guides research as an invited expert reviewer or committee member for the Dutch Organization for Scientific Research (NWO), for the German (DFG) Research Innovation Scheme and for the European Union (ERC Starting/Consolidation Grant mechanisms). He is a full consortium member of the EU Human Brain Project (HBP), in which three hundred experts in neuroscience, medicine and computing joined to develop the HBP vision for brain research and its applications in Europe. Goebel was recently appointed as advisor to the working group on the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, a USA presidential research program on Brain Research. In the context of his research on real time fMRI, Goebel cooperates with world leading laboratories from Stanford University, USA; University College London and Cardiff university UK; and, Swiss Federal Institute of Technology, Zurich, Switzerland; University of Alberta, Edmonton, Canada; and Georgia Institute of Technology, Atlanta, USA. The collaboration is funded via EU FP7. In the context of developing high resolution fMRI he collaborates with other high field centres, such as the Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, USA; Forschungszentrum Jülich, Germany; the Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, and the Max Planck Institute for Biological Cybernetics, Tübingen, Germany.

Proven ability to attract foreign researchers Since his appointment as full professor at Maastricht University from January 1st, 2000, Rainer Goebel has built up a truly international research group. Based on his reputation, he was able to engage professor Elia Formisano (It; 2000), professor Peter de Weerd (Be; 2003), professor Alex Sack (Ger; 2003), professor Francesco Di Salle (It; 2007 – 2010, honorary position from 2011), professor N. Jon Shah (GB; honorary position, 2010) professor Paul Matthews (GB; honorary position , 2012); and professor Beatrice de Gelder (Be; 2012). At the level of associate and assistant professors, the Goebel group hired Kamil Uludag (Ger/Tur), Federico Di Martino (It), Giancarlo Valente (It), Federica Vatta (It), Benedikt Poser (Ger), Fabrizio Esposito (It), Bettina Sorger (Ger), and Teresa Schuhmann (Ger). At the moment, about 75% of the postdocs and PhD students of Goebel’s group are of non-Dutch origin, coming from Belgium, France, Germany, Italy, Portugal, Spain, the

150 UK, Serbia, Australia, Brazil, Canada, China, Columbia, India and Iran. In total, 61% of the researchers of Goebel’s Cognitive Neuroscience department are from outside The Netherlands. Additionally, foreign scientists at every level visit Maastricht regularly to work together with Rainer Goebel or spend there their period of sabbatical leave (e.g. Prof. Walter Schneider, University of Pittsburgh, US, Dr. Gregor Adriany, Center for Magnetic Resonance Research, Minneapolis, US).

Evidence of recognition (prizes, honorary doctorates, editorial memberships) Rainer Goebel is member of the editorial board of NeuroImage, Frontiers in Brain Imaging Methods and Social Cognitive and Affective Neuroscience (SCAN). He acts as member of selection committees for NWO (e.g. VICI granting scheme) and the ERC. Other expressions of esteem are: 1993 Heinz-Maier-Leibnitz Advancement Award 1993 in Cognitive Science from the German minister of science and education for work on neural networks and the binding problem 1994 Heinz-Billing Award 1994 for the neural network simulation program "Neurolator" from the Max Planck society for scientific computation 1996 – 1998 Member of the "Sonderforschungsbereich Nichtlineare Dynamik" (SFB: Nonlinear Dynamics) of the German Science Foundation 1998 Fellow at the Institute for Advanced Studies in Berlin, Germany 2001 - 2009 Research fellow and member of the board of governors of the F.C. Donders Centre for Cognitive Neuroimaging, Nijmegen 2004 Programming award for didactic software "BrainVoyager Brain Tutor" see: http://www.trolltech.com/campaign/maccontest_winners.html 2005 Member of "Keur der Wetenschap" (selected Dutch "Cream of Science" researchers) 2006 - 2009 Chair of "The Organization for Human Brain Mapping", Chair-elect 2006/2007, Chair 2007/2008, Past- Chair 2008/2009 2008 - Member of the Netherlands Institute for Neuroscience (NIN, http://www.nin.nl) of the Royal Netherlands Academy of Arts and Sciences (KNAW) (20% part-time employment) 2013 EU Human Brain Project, member.

Past performance in national and international funding competitions 2000 USA Grant, McDonnell-Pew Program in Cognitive Neuroscience 2001 Human Frontier Science Program (HFSP) Grant "In Vivo Visualization of Axonal Connectivity and Functional Activity Using Diffusion Tensor MRI" (180.000 $) 2002 Dutch Grant, NWO (Netherlands Organization for Scientific Research) “Investigating top-down and bottom-up control of visual selection with functional MRI.“ 2003 "Alzheimer Forschung Initiative" (project grants for fMRI in AD research) 2004 Breedtestrategie (“Widening Strategy”) of Maastricht University € 1.000.000 2005 Dutch Grant, NWO "Open Competition" (PhD position) 2006 EU Grant “Dyslexia genes and neurobiological pathways” (NeuroDys) 2007 Dutch Grant, “SmartMix” program (mix of academic and industrial institutions): “BrainGain”, BCI research, own project: fMRI-based neurofeedback (~800.000 €) 2008 EU Marie Curie ITN “CODDE” (co-applicant via Brain Innovation BV) 2009 NWO Graduate School programme (co-author with major contribution; FPN Maastricht University) € 800.000 2009 EU Grant, Marie Curie Initial Training Networks (ITN): “Cerebellar-Cortical Control: Cells, Circuits, Computation, and Clinic” (C7), as industrial partner (Brain Innovation BV) 2009 EU Grant, Marie Curie Initial Training Networks (ITN): “Coordination for optimal decisions in dynamic environments” (Codde), as industrial partner (1 PhD) 2009 EU Grant, Marie Curie Initial Training Networks (ITN): "Methods in Neuroimaging" (NeuroPhysics, co-applicant, € 3MIO). 2010 Dutch Grant, NWO Middle-size investment: "A Virtual Reality laboratory for psychological and neuroscientific investigations of normal and deviant human behaviour. (€ 640.000) 2010 EU Grant "Deployment of Brain-Computer Interfaces for the Detection of Consciousness in Non-Responsive Patients" (DECODER) (€ 480.000) 2011 ERC Advanced investigator Grant € 2.473.481 2012 EU Marie Curie ITN “Advanced Brain Computations (ABC)” (co-applicant via Brain Innovation BV, € 500.000) 2013 NWO-MaGW Medium-sized Investments € 500.000 2013 EU Human Brain Project (€ 1.200.000 in 2016-2023) 2013 EU FP7 Health “IMAGEMEND” (co-applicant via Brain Innovation BV, € 800.000 )) 2013 EU FP7 Health “BRAINTRAIN” (co-applicant via Brain Innovation BV, € 1.800.000))

151 Ability to develop a scientific/scholarly movement in the Netherlands and abroad (schoolvorming) Rainer Goebel has been among the first scientists to have the intuition that breakthroughs in understanding the human brain will originate from a multidisciplinary approach that addresses relevant psychological questions (e.g. conscious perception) with state-of-the-art and innovative technologies (e.g. high field imaging, multimodal imaging), computer modeling and analyses techniques. Rainer Goebel’s idea to use computational modelling to link different data types and analysis outcomes in integrated models of the brain has now propagated in the Netherlands and worldwide through the work and research of many other scientists (see also point 5). The research on visual perception by Dr. Nikolaus Kriegeskorte (Cambridge University, UK, ERC Young investigator, former Phd student of Goebel) and by Prof. Lars Muckli (Glasgow University, UK, ERC Consolidator and former Phd Student of Goebel), the fMRI neurofeedback work in patients of Prof. David Linden (Cardiff University, UK, former PhD Student of Goebel) and in the Netherlands, the research on auditory perception by Prof. Elia Formisano (Maastricht University, VIDI & VICI laureate, former postdoc of Goebel) provide relevant examples of research combining high resolution imaging and computational modeling and are largely inspired by Rainer Goebel.

Leadership qualities Rainer Goebel’s enthusiastic and inspirational character attracts and nurtures young research talent from all over the world. In addition, his collaborative and content driven manner attracts many world-leading scientists to work with Rainer Goebel and members of his team. Starting in 2000, Rainer Goebel built up Cognitive Neuroscience (CN) with a few team members.. This group developed towards a successful research and teaching department with currently 25 fte directly funded and around 75 fte indirectly funded staff. Rainer Goebel was a founding father of the one year Master of Science (Track Cognitive Neuroscience), and of the two-year Research Master Program, especially the variant Cognitive Neuroscience (total 100 students, of which 35 cognitive neuroscience related). His vision for the need of a graduate program for PHD students resulted in successful European (2008) and NWO (2009) funding to hire and train PhD students at an international and interdisciplinary level with links to Industry (in this case pharma industry GSK). In 2005, he initiated the Maastricht Brain Imaging Center (M-Bic) with currently 8 principal investigators, organized in matrix structure crossing CN method development (TMS, EEG, high field fMRI, real time fMRI based neurofeedback, blind source separation techniques, multivariate pattern analysis) with cognitive science themes (visual and auditory perception, attention, language, neural plasticity). It is Rainer Goebel’s expertise of the interdisciplinary field (psychology, engineering, medicine, economy) that guides scientists within CN and M-BIC towards excellent research. He also served in the board of the faculty of psychology and neuroscience from 2005 – 2010 responsible for research and innovation. Rainer Goebel is driven by content in the most positive way, and he is able to transfer this enthusiasm such that his group proactively contributes to paving future developments in the field. He always does so in a modest way, knowing exactly where the limits of new methods are. Rainer Goebel inspires scientists in other faculties (Medical , Business and Economics, Mathmatics, Physics) to think interdisciplinary, and to collaborate, and to combine fundamental research with applications to tackle complex problems of society (Health, Human decision making, computational modeling of complex systems).

Expectations with regard to future contributions to the relevant field of research Rainer Goebel’s drive to use methodological and technological advances to develop an increasingly unified understanding of human cognition is culminating in his current research. In 2011, he received an ERC Advanced Investigators award for the visionary research program “Cracking the columnar-level code in the visual hierarchy: Ultra high-field functional MRI, neuro-cognitive modelling and high-resolution brain-computer interfaces” combining three lines of his previous research in a focused research program. While Goebel recognizes and contributed to the discoveries with standard functional brain imaging at the macroscopic level (i.e. fMRI at 3 Tesla), he argues that little is still known about the representations coded inside specialised brain areas and how complex features emerge from combinations of simpler features when we move from one area to the next. With high-field MRI scanners as those recently installed in Maastricht (7 and 9.4 Tesla), the achievable functional resolution can reach the sub-millimetre level (500–1000 microns). This is important for his future work since neurons with similar response properties cluster into functional units or cortical columns with a lateral extent of hundreds of microns. He argues that studying the brain at the mesoscopic level of cortical columns and cortical layers seems to be the right approach to reveal the principles that the brain uses to code information. The current and future research by Rainer Goebel has thus the potential to “crack” this columnar-level code by adequately combining clever experimental designs (psychology), sub-millimetre fMRI (neuroimaging), sophisticated data analysis tools (signal analysis) and large-scale neuronal network modelling (computational neuroscience). Goebel believes that a massive attempt to crack the columnar- level code in as many areas as possible will ultimately lead to a deeper understanding how mind emerges from simpler units in the brain. Thanks to his enormous talent for multidisciplinary integration and innovation, Rainer Goebel will be the first to bring within reach the amazing prospect of visualizing and modelling the interactions among functional units delineated at a submillimeter scale in the perceiving, thinking, feeling and communicating human brain. Hence, Rainer Goebel’s nomination is not only for the exceptional impact of his past career, but even more for the importance of the current orientation of his research, which we believe will lead to truly fundamental new insights in the mechanisms of human cognition.

152 Proven ability to attract young researchers Rainer Goebel has had strong educational and inspirational impact on the scientific formation and success of many researchers he met in various roles, both at the Max-Planck Institute in Frankfurt and at Maastricht University. These include Miguel Castelo-Branco (professor at Coimbra University, Portugal and director of the local imaging centre), Elia Formisano (professor of Neuroimaging Methods at Maastricht University), Nikolaus Kriegeskorte (PI at the MRC unit in Cambridge, UK), David Linden (professor of Translational Neuroscience at Cardiff University, UK), Lars Muckli (professor of Cognitive Neuroscience, Glasgow University), Alex Sack (professor of Magnetic Stimulation, Maastricht University). Rainer Goebel’s enthusiastic and inspirational character also underlies his success in building and managing his own large group at Maastricht University, and in convincing political leaders in the Netherlands to help build his already internationally renowned imaging centre. To support his current research line on high field MRI, Goebel has been able to attract a group of brilliant, young yet internationally recognized scientists (Federico De Martino, Alard Roebroeck, Benedikt Poser, Kamil Uludag). In addition, in his teaching at the bachelor, master and PhD level, Rainer Goebel is legendary for his insightful and enthusiastic teaching style. This reputation is exemplified by a recent invitation of the Max Planck society to act as a keynote speaker in the conference “Visions in Science – Shaping the Future” that targets junior scientists across various fields of science. With Faculty of Psychology and Neuroscience regard to PhD education, he also plays a prominent role in the international EU PhD training network NeuroPhysics and the NWO graduate school Cognitive and Clinical Neuroscience of the faculty and partners. In addition, he is a wanted teacher in external programs, including the yearly two-week autumn school of the Studienstiftung des deutschen Volkes (German National Academic Foundation) about brain imaging, artificial intelligence, neural networks and consciousness.

Knowledge exchange and impact Rainer Goebel’s work has important societal impact. He is the inventor and developer of the software package “BrainVoyager” that is used in more than 500 laboratories around the world and is considered as one of the standard software packages for advanced multi-modal neuroimaging data analysis. His company Brain Innovation (http://BrainVoyager.com) commercially distributes BrainVoyager and has created jobs for 20 people (8 from revenues, 12 from recent EU funding) working in support, research and development. The broad sharing of his methodological expertise through Brainvoyager not only has strong scientific impact, but also has applied significance, as it provides a platform for multiple therapeutical approaches for various psychiatric afflictions. For example, Brainvoyager enables real-time analysis of fMRI data necessary for neurofeedback approaches to treat phobia, depression, and motor deficits. Moreover, Brainvoyager is a crucial part of the brain-computer interface (BCI) that permits communication with patients in a state of decreased consciousness, or with locked-in patients. Currently, Rainer Goebel develops a portable NIRS device that may replace the fMRI scanner as a BCI during neurofeedback-based treatment of disorders, or communication. Brainvoyager is also a platform for the integration of multiple methods, such as EEG, MEG, TMS and (f)MRI. His TMS neuronavigation system is useful in clinically oriented work aimed at treating neglect after parietal stroke. He has developed a software package for neural network building (Neurolator), and a downloadable app for i-phone and i-pad to visualize structure and function of the human brain (Brain Tutor, downloaded 800.000 times, and the award-winning BrainMatters app (www.brainmatters.nl/app) together with PhD students), i.e. tools with both scientific and educational value. Rainer Goebel also participates in pioneering work on the genetic determinants of cognition (Science, 2009) – an approach that holds great applied promise. Rainer Goebel also contributed as a speaker to the “Avond van Wetenschap en Maatschappij” (evening of science and society) where members of Dutch politics and media meet scientists to obtain insights in the latest developments of their research. Rainer Goebel’s work is highlighted regularly in the media.

153

Selected 10 Publications with High Impact

Sorger, B., Reithler, J., Dahmen, B., Goebel, R. (2012). A Real-time fMRI-based Spelling Device Immediately Enabling Robust Motor-independent Communication. Current Biology, 22, 1333-1338. The first real-time fMRI based brain-computer interface allowing to communicate not just with yes/no answers but with full words and sentences using online letter-by-letter decoding of distributed brain activity. This is now successfully used for the first patients in a hospital in Liège, Belgium.

Tamietto, M., Pullens, P., de Gelder, B., Weiskrantz, L., Goebel, R. (2012). Subcortical Connections to Human Amygdala and Changes following Destruction of the Visual Cortex. Current Biology, 22, 1449-1455. Fiber tracking techniques based on diffusion tensor imaging (DTI) was used to reveal subcortical pathways in the human brain that underlie subconscious emotional processing in healthy individuals and that seem to be strengthened in a blindsight patient. This work has strong implications on contemporary theories of consciousness.

Zimmermann*, J., Goebel*, R., De Martino, F., van de Moortele, P.F., Feinberg, D., Adriany, G., Chaimov, D., Shmuel, A., Uğurbil, K. & Yacoub, E. (2011). Mapping the organization of axis of motion selective features in human area MT using high-field fMRI. PLoS One,, 6, e28716. * = authors contributed equally Using ultra-high magnetic field strength (7 Tesla), this study showed for the first time how a mid-level visual brain area is functionally organized at the mesoscopic level of cortical columns and cortical layers. The developed topographic sub- millimeter mapping tools are now used to unravel the functional code in many visual, auditory and multisensory areas of the human brain.

Esposito, F. & Goebel, R. (2011). Extracting functional networks with spatial independent component analysis: the role of dimensionality, reliability and aggregation scheme. Current Opinion in Neurology, 24, 379-385. This didactic methodological paper describes the state-of-the-art approaches for group studies using the data-driven analysis method independent component analysis (ICA). The explanations will help neurologists and psychiatrists to understand this important tool better and to draw valid conclusions from its application.

Goebel, R., Zilverstand, A. & Sorger, B. (2010). Real-time fMRI-based brain–computer interfacing for neurofeedback therapy and compensation of lost motor functions. Imaging in Medicine, 2, 407-414. Review on state-of-the-art real-time fMRI analysis and ho wit can be applied for clinical applications.

Formisano, E., De Martino, F., Bonte, M., Goebel, R. (2008). "Who" is saying "what"? Brain-based decoding of human voice and speech. Science, 322, 970-973. Advanced machine learning tools were developed and applied showing that it is possible to segregate ‘what is said’ from ‘who is talking’ from distributed activity patterns in auditory cortex.

Kriegeskorte, N., Formisano, E., Sorger, B., Goebel, R. (2007). Individual faces elicit distinct response patterns in human anterior temporal cortex. Proc Natl Acad Sci USA, 104, 20600-20605. We discovered an area in human anterior inferior temporal cortex that exhibited differential distributed activity patterns for individual faces. The developed “searchlight” classifier is now one of the most used tools in fMRI “brain reading” applications.

Sack, A.T., Camprodon, J.A., Pascual-Leone, A. & Goebel, R. (2005). The dynamics of inter-hemispheric compensatory processes in mental imagery. Science, 308, 702-704. Using advanced transcranaial magnetic stimulation (TMS), it was demonstrated for the first time in the human brain how one hemisphere can dynamically take over the function usually done by the other hemisphere. It has strong implications for plasticity and rehabilitation for stroke patients.

Formisano, E., Kim, D.-S., Di Salle, F., van de Moortele, P.-F., Ugurbil, K. & Goebel, R. (2003). Mirror-symmetric tonotopic maps in human primary auditory cortex. Neuron, 40, 859-869. This is the first neuroscience application of ultra-high magnetic field (7 Tesla) revealing topographic maps of sound frequencies in early auditory cortex.

Castelo-Branco, M., Goebel, R., Neuenschwander, S. & Singer, W. (2000). Neural synchrony correlates with transparency rules constraining visual surface segregation. Nature, 405, 685-689. This paper provided strong evidence that neuronal synchronization solves the „binding problem“ by demonstrating that the same neuronal cell populations dynamically change their temporal coupling depending on perceptual interpretation of a moving stimulus.

154 Relevant numeric data

 PhD graduations supervised since full professorship: 31 (1st supervisor; 3 cum laude) + 9 (2nd supervisor; 2 cum laude)  Number of invited lectures: 15 per year  Number of refereed articles: 246  Number of books: none  Number of book chapters: 27  H-index: 55 (Web of Science) / 67 (Google Scolar)  Number of citations: > 10.000

155

Faculty of Psychology and Neuroscience

Prof. dr. Elia Formisano Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience Maastricht Brain Imaging Center (MBIC) Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands, Phone: +31 43 38 84040, Fax: +31 43 3884125 e-mail: [email protected]

Dear OHBM Council,

It is with great pleasure and enthusiasm that I recommend Rainer Goebel for the OHBM Glass Brain Award.

I have met Rainer for the first time more than twenty years ago (in 1994). As a young master student willing to conduct a research thesis in Biomedical Engineering/Imaging, I was lucky to land in Frankfurt exactly when the enthusiasm for the recently discovered BOLD fMRI (mixed with some skepticism of the single-cell neurophysiologists) was pervading the local neuroscience community and a gradient system capable of echo planar imaging had become available on the clinical 1.5 Tesla MR scanner at the hospital. Needless to say, the enthusiasm and chill for this new technique was mostly fuelled by Rainer who decided to expand his line of research on the human brain and explore the new possibilities offered by fMRI. This led to the foundation of the functional neuroimaging group at the Max Planck Institute for Brain Research in Frankfurt/Main in the Dept. of Neurophysiology of Prof. Wolf Singer. Since then, I had the privilege to collaborate with Rainer on many research projects, co-develop with him new analysis methods and progressively build up in Maastricht (The Netherland) a world-level infrastructure for (functional) MRI research. At the present, the imaging center headed by Rainer hosts research-dedicated 3, 7 and 9.4 Tesla MR scanners for human imaging and more than a hundred active researchers.

I am firmly convinced that Rainer deserves the OHBM Glass Brain Award because of the central role he has had and has within the international neuroimaging research community. Rainer has been among the first scientists to have the intuition that breakthroughs in understanding the human brain originate from a multidisciplinary approach that addresses relevant psychological and neuroscience questions (e.g. conscious perception) with state-of-the-art and innovative technologies (e.g. advanced data analysis and modeling, high field imaging, multimodal imaging). This vision, transmitted with enthusiasm and passion, has inspired and continues to inspire many under-graduate and graduate students, researchers and collaborators from many disciplines. Rainer’s centrality and relevance for neuroimaging/neuroscience is demonstrated by his many achievements during the last twenty years (see Attachments). Rainer has authored many influential neuroscientific publications (on vision, audition, multisensory

Visiting address T +31 (0)43 388 22 22 Bank account: 065.76.25.418 Universiteitssingel 40 F +31 (0)43 388 52 47 IBAN: NL47 INGB 0657 6254 18 6229 ER Maastricht www.maastrichtuniversity.nl BIC: INGBNL2A

Postal address P.O. Box 616 VAT identifier EU 6200 MD Maastricht NL0034.75.268.B01 The Netherlands 156 integration, mental imagery) in prestigious journals, including Nature, Science, Nature Neuroscience, Neuron, PNAS, Current Biology; similarly influential are his methodological contributions (e.g. cortex-based algorithms for inter-subject realignment, real-time fMRI data analysis, independent component analysis, Granger Causality, multivariate pattern analysis) regularly published in Neuroimage or Human Brain Mapping. Rainer is the developer and main programmer the software package “BrainVoyager”. This software has evolved from an internal lab tool into a high-quality commercial software package used in more than 500 laboratories around the world. Rainer’s company Brain Innovation (http://BrainVoyager.com) commercially distributes BrainVoyager and has created jobs for 20 people (8 from revenues, 12 from recent EU funding) working in support, research and development. Rainer has showed his commitment to OHBM by acting as Chair of the organization (2006-2008). Rainer has recently received an ERC Advanced Investigators award (2011) for the innovative research program “Cracking the columnar-level code in the visual hierarchy: Ultra high-field functional MRI, neuro-cognitive modelling and high- resolution brain-computer interfaces”, which combines his main lines of research on neuroscience of vision, modelling and (fMRI-based) neurofeedback and promises new exciting results and developments.

In sum, I would be very glad if the OHBM council would decide to award Rainer Goebel with the OHBM Glass Brain Award. This would be a rightful recognition of Rainer’s past and present enormous contribution to the neuroimaging community.

Sincerely,

Elia Formisano

157

MRC Centre for Neuropsychiatric Genetics and Genomics Institute of Psychological Medicine & Clinical Neurosciences Email: [email protected] 14 March 2014

Dear Dr Kriegeskorte it is an absolute delight to support your nomination of Professor Rainer Goebel for the OHBM Glass Brain Award.

Professor Goebel is one of the most eminent neuroimaging scientist (and cognitive neuroscientists more general) of our time. Through his combination of multimodal neuroimaging, experimental psychology and computer modeling, he has made seminal contributions to our understanding of the visual and other sensory systems, topographical structures, multisensory integration, imagery, and the constructive nature of perception in general. He is also the driving force behind one of the most widely used imaging software packages, BrainVoyager. I can attest, from my own experience as a former mentee and longstanding collaborator, to his unique commitment to mentoring of junior researchers, which has shaped and encouraged an entire generation of young neuroscientists. Professor Goebel has also been a longstanding supporter of the OHBM, including terms of service in its most senior roles. He would be the ideal recipient for the Glass Brain Award.

Yours sincerely,

David Linden, MD, DPhil (Oxon) Professor of Translational Neuroscience

158 Max-Planck-Institut für biologische Kybernetik Max Planck Institute for Biological Cybernetics

MPI für biologische Kybernetik  Spemannstr. 38  D-72076 Tübingen

Prof Nikos K. Logothetis Director Tel.: +49-(0) 7071 / 601 - 650 Fax: +49-(0) 7071 / 601 – 652 [email protected]

To: http://www.kyb.tuebingen.mpg.de Organization for Human Brain Mapping (OHBM) 5841 Cedar Lake Road, Suite 204 Minneapolis, MN 55416 USA [email protected] www.humanbrainmapping.org

Friday, March 14, 2014

Dear members of the selection committee: I am writing to enthusiastically support the nomination of Rainer Goebel for the Glass Brain Award of the Organization for Human Brain Mapping. I have followed Rainer’s work over the years, and am familiar with his accomplishments. I have never formally collaborated with or mentored Rainer, so I feel that I am able to provide you with an independent and objective evaluation indeed. Rainer Goebel is an outstanding investigator in the field of cognitive and computational human neuroscience, with research interests extending from large-scale neuronal network modeling to microcircuits, connectivity, neurofeedback and brain computer interfaces. In general, he seeks to understand the neural representations used in functionally specialized brain areas, and how such representations enable various perceptual and cognitive functions. To this aim he uses successfully a highly multidisciplinary and multimodal approach. Multidisciplinary, as his research relates to all sensory systems as well as to higher-level cognitive functions, including mechanisms of multisensory integration, attention, memory, and consciousness. And multimodal, because he successfully combines data from a large array of methods, including behavioral approaches, TMS/DCS, EEG, fMRI, NIRS, and recently molecular/genetic approaches (Koten et al., Science, 2009). Because of the depth of insight afforded by integrative approach, and because of his expertise in computer science and modeling, his publications have strong impact. Beyond his outstanding training, experience and scientific insights, his success and impact is also further enhanced by the enthusiastic way, with which he shares his insights during talks at conferences, and from the multitude of international collaborations that are often strongly contingent on Rainer Goebel’s

Spemannstr. 38 Tel.: +49-(0) 7071 / 601 - 650 [email protected] 159 D-72076 Tübingen Fax: +49-(0) 7071 / 601 - 652 www.kyb.tuebingen.mpg.de Max-Planck-Institut für biologische Kybernetik Max Planck Institute for Biological Cybernetics

MPI für biologische Kybernetik  Spemannstr. 38  D-72076 Tübingen

input and expertise. It goes without saying, the scientific community also highly profits from the development of his BrainVoyager, which is a worldwide used, user-friendly software package that brings sophisticated analysis methods at the fingertips of the user, and Neurolator, which is a software package that he is developing to facilitate the building of neural networks used to test mechanisms underlying patterns of (fMRI) data. Finally, Rainer’s research has important applied contributions, as witnessed by his work on the development of BCIs for communications with patients with reduced consciousness (through fMRI or NIRs), and on neurofeedback techniques in the treatment of psychiatric disease. In summary, Rainer Goebel is a leading figure in the field who is highly appreciated both because of the quality of his science and his inspiring and helping character. Notably, Rainer Goebel has recently embarked on an ambitious interdisciplinary research project that includes the use of (ultra)-high field fMRI to functionally distinguish the smallest processing elements in low-level (sensory) neocortex: cortical columns and layers. The latter follows his invention of so-called “Common Brain Space” (CBS), a modeling approach that links modeled cortical columns to locations in the brain of scanned individuals via network-brain links (NBLs): When running a network simulation, the produced activity is projected on the brain producing detailed spatio-temporal predictions. The CBS approach allows for the first time to simulate and predict individual topographic neuroimaging data at different levels of organization reaching from networks to areas to columnar features; the CBS approach has been applied to model visual illusions, selective visual attention and invariant object recognition. While the CBS modeling can be used with standard neuroimaging data, the predictive power will be limited to statements about mean activity levels in specialized areas or topographic retinotopic representations in early visual areas. He therefore decided to combine the developed modeling approach with ultra-high field fMRI data obtained from the columnar and lamina projects as mentioned above. This will allow to produce simulations that make highly specific sub-millimeter topographic predictions and enables using fMRI data as strong constraints to select between alternative models that fit equally well when using standard resolution fMRI data. Importantly, Rainer Goebel knows that in order to perform this work well, the many steps to be taken in this research have to be validated by parallel research in the non-human primate (NHP). This is because fMRI is a measure of blood flow, related only in an indirect and poorly understood manner to neural activity. Hence, fMRI methods suggesting the possibility to isolate specific functional units or functional interactions among them should be validated by direct measured of neural activity in parallel NHP experiments. High-field and ultra-high-field fMRI will live up to their promise only if combined with NHP work (and other work with animal models). Despite the lack of support at the level of university leaders and national politics in the Netherlands for NHP work, Rainer Goebel is consistent in pursuing combined human/NHP experiments, by setting up

Spemannstr. 38 Tel.: +49-(0) 7071 / 601 - 650 [email protected] 160 D-72076 Tübingen Fax: +49-(0) 7071 / 601 - 652 www.kyb.tuebingen.mpg.de Max-Planck-Institut für biologische Kybernetik Max Planck Institute for Biological Cybernetics

MPI für biologische Kybernetik  Spemannstr. 38  D-72076 Tübingen

collaborations with Pieter Roelfsema (NIN, Netherlands) and Wim van Duffel (KUL, Belgium). He thus plays a very important role in counteracting the strong and rather opportunistic stream in psychology and cognitive science to move away from animals models – something that risks to become a historical mistake in the field. All in all, Rainer Goebel is without a doubt one of the most important contemporary leaders in psychological and cognitive sciences. I enthusiastically support his nomination.

Yours sincerely,

Professor Nikos K. Logothetis Max Planck Institute for Biological Cybernetics (MPIC) Director of Department of Physiology of Cognitive Processes Spemannstraße 38 72076 Tübingen Germany Tel: +49-7071-601-650 Tel: +49-7071-601-651 (Secr.) Fax: +49-7071-601-652 Email: [email protected] http://www.kyb.tuebingen.mpg.de/research/dep/lo.html

Spemannstr. 38 Tel.: +49-(0) 7071 / 601 - 650 [email protected] 161 D-72076 Tübingen Fax: +49-(0) 7071 / 601 - 652 www.kyb.tuebingen.mpg.de

Organisation for Human Brain Mapping Council OHBM Glass Brain Award Nomination

Glasgow, 26 February 2014

Dear OHBM Council,

Re. Support for the nomination of Professor Rainer Goebel for the first OHBM Glass Brain Award

It is an excellent idea for the OHBM to provide a lifetime achievement award for neuroimaging. I am more than delighted to write in favour of Rainer Goebel, who is the perfect recipient for this honour. Rainer joined OHBM in its second year (Boston, 1996) and has never since missed the conference. Rainer Goebel is an immense inspiration for so many, and is celebrated across the field of neuroscience. In Maastricht, he heads one of the largest functional brain imaging centre (with 3T, 7T, and 9.5T). He is on the advisory board of a top brain imaging centre in the US (Stanford) and across Europe (Portugal, Germany, UK). His time as President of the OHBM has been very successful; through collaborations across the globe he is known to many, and even more will have enjoyed his motivational training in brain imaging techniques and analysis.

As one of Rainer’s first PhD students, I was so privileged to witness his incredible wisdom, dedication and enormous creativity. Even today, there are no more inspirational moments for me than time spent interacting with Rainer. My best advice to students and colleagues is to observe this motivational boost for themselves by meeting with Rainer. With his support and guidance, many people have realized their own ambitions and research objectives. Rainer always encourages others to forge new boundaries as he does himself, fostering communication across different areas of neuroscience. For example, Rainer is greatly respected not only in the brain imaging community but also in the field of systems level neuroscience and the neuronal modelling community. His dream for multidisciplinary neuroscience and multimodal brain imaging has been seminal.

Rainer’s genius was recognised early on he was appointed fellow at the prestigious Institute for Advanced Studies in Berlin in 1998. Prior to that, in 1995, Rainer began programming the brain imaging analysis tool of BrainVoyager, which has ever since been an influential cortex-based tool of choice for many. More recently, Rainer has been fundamental in promoting the immense potential of functional brain imaging for the investigation of high-resolution, fine- grained structures. Within this area, he is exemplary in his astute experimental approaches. He has been central to the initiation of the brain reading challenges at OHBM meetings, again 162

striving for innovative empirical strategies. The success of brain imaging depends to a large extent on the development of new methods and experimental strategies. Rainer is inimitable in his push for revolutions in all of these domains. His research into real-time, surfaced-based fMRI has triggered important tool development, including his seminal work on high-field brain imaging of tonotopic maps, the combination of TMS and brain imaging, the development of high field DTI techniques, granger causality mapping and ICA, to name but a few. The brain imaging centre that Rainer heads in Maastricht is a hub for pioneering fMRI analysis developments, with its current push for columnar and layer-specific fMRI.

Rainer’s approach to neuroscience is ahead of its time. A OHBM Glass Brain lifetime award for Rainer Goebel would be visionary. Such a great honour would recognise Rainer’s exceptional contributions to the field that are second to none, as well as his ongoing drive and dedication to voyaging into the future of brain imaging.

Thank you for your consideration Best regards

Lars Muckli

Lars Muckli, PhD Professor of Visual and Cognitive Neurosciences

Centre for Cognitive Neuroimaging, Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences 58 Hillhead Street, G128QB, Glasgow [email protected]

The University of Glasgow, charity number SC004401 163 UNIVERSITY OF MINNESOTA

Twin Cities Campus Center for Magnetic Resonance Research 2021 Sixth Street SE Medical School Minneapolis, MN 55455 612 626 2001 Fax: 612 626 2004

27 February 2014

To: OHBM Council Re: Nomination of Rainer Goebel for OHBM Glass Brain Award.

With great pleasure and enthusiasm, I would like to nominate Rainer Goebel for OHBM Glass Brain Award.

Rainer Goebel is a highly accomplished neuroscientist whose work has immensely impacted the research field that is central to OHBM. Particularly his effort focused on mapping human brain function with magnetic resonance imaging (i.e. fMRI), combining the fMRI approach with computational models to understand human brain function, and developing computational tools for analyzing neuroimaging data obtained with MRI in general and fMRI in particular has been vastly influential in the cognitive neuroscience and functional imaging communities in general, and especially in the OHBM community.

Rainer Goebel pioneered the integration of cognitive psychology, computer science, and neuroscience to study visual perception. His first publication on neuronal synchronization (1990), shortly before the days of fMRI, was awarded with the “Heinz-Maier-Leibnitz Advancement Award”. Adopting fMRI as his primary interest, shortly after the introduction of the technique, he has rapidly become a pioneer in this new field and author of early and highly cited and influential papers on visual illusions and mental imagery, apparent motion, structure-from- motion perception, and blind sight.

Rainer’s internationally recognized work is characterized by a synergy between method development and applications. He has developed new data analysis tools and methods that are used worldwide, particularly in the OHBM community, including brain segmentation and alignment, data-driven analysis (cortex-based independent component analysis, and Granger Causality Mapping. He advanced the integration of multiple research methods (e.g. combination fMRI and EEG/MEG; simultaneous measurement of fMRI and TMS; real-time fMRI analysis; fMRI-based neuro-feedback).

Rainer Goebel is also recognized as the inventor and developer of the software package “BrainVoyager” that is used extensively laboratories around the world and is considered as one of the standard software packages for advanced multi-modal neuroimaging data analysis. Brain Voyager has evolved to be one of the most influential software in neuroimaging research and is at the core of numerous publications in leading neuroscientific journals coming not only from his group but also from many other laboratories worldwide.

The recognition of Rainer Goebel’s contributions scientific topics of interest to the general OHBM community can also be garnered from the fact that he is member of the editorial board of

164 Page 2

Neuroimage, Frontiers in Brain Imaging Methods, and Social Cognitive & Affective Neuroscience. He has been an invited expert in numerous selection committees for research funds like the ERC Starting/Consolidation Grant. He was recently invited as an advisor to the Working Group of fifteen scientists charged with developing the strategy for the BRAIN (Brain Research through Advancing Innovative Neurotechnologies) Initiative, an initiative launched by President Obama in the US. And, of course, he has acted as chair of the OHBM.

Rainer Goebel also has had a large influence on the scientific formation of many researchers who are now also active in the scientific disciplines of interest to OHBM. Many of his students are now in prestigious academic positions in several fields of fundamental, cognitive and clinical neuroscience. These include researchers like Miguel Castelo-Branco, Elia Formisano, Nikolaus Kriegeskorte, Lars Muckli, and others. In Maastricht, Goebel has been able to build an internationally renowned multidisciplinary research group and an impressive imaging center. With this center finally functioning fully in 2014, his impact and influence is sure to expand significantly.

In summary, I believe Rainer Goebel has been a critically important figure in the OHBM community who has had immense contributions to the neurosciences and neuroimaging fields. He is absolutely meritorious of the OHBM Glass Brain Award and I do hope that you share this view with me.

Sincerely yours,

Kâmil Uğurbil Director, Center for Magnetic Resonance Research McKnight Presidential Endowed Chair Professor in Radiology Professor, Departments of Radiology, Neurosciences, and Medicine

2 165 Stanford University

Professor Brian A. Wandell [email protected] Stanford Center for Cognitive and Neurobiological Imaging (CNI) Phone: 650 725 2466 Psychology Department http://www.stanford.edu/~wandell Stanford University Stanford, CA 94305-2130

March 14, 2014 Dear Colleagues,

I am pleased to write this letter supporting Rainer Goebel for the Glass Brain Award. I have known Rainer Goebel and followed his many activities closely for over a decade. Rainer has several strengths, and I have separated out this letter into sections reflecting these contributions. He is surely best known for his great skill as a tool-builder. Second, he has made significant and specific contributions in applying fMRI to important questions in the field psychological and cognitive science. Third, he is an international leader who develops programs and communicates the excitement and breadth of cognitive neuroscience to the world community.

Tool development Goebel is best known for the major impact of his methodological contributions. In the field of cognitive neuroscience, tool-building is central. In my view, we should acknowledge how important software, statistical and visualization methods are to our enterprise. Goebel is surely an important leader in creating these tools. For example, an important topic in his research offers solutions to the difficulties in combining the data from multiple human brains in order to perform acceptable group statistics. Goebel developed very attractive tools for morphing and aligning human brains to achieve correspondence based on anatomical and/or functional criteria (Frost & Goebel, Neurimage, 2013). Along with his student Kriegeskorte, Goebel has been instrumental in pushing new developments in fMRI data analysis, such as the use of multi voxel pattern analysis (MVPA) to measure distributed brain activity during cognitive tasks (Nikolaus Kriegeskorte et al., 2006; Staeren et al., Current Biology, 2009; Formisano et al., Science, 2012). These methods are instrumental in identifying and distinguishing representations during, among others, perceptual, categorization, imagery, and working memory task, as well as representational changes after the formation of long-term memories. Goebel is best known for a software tool that he built for visualization and analysis, called BrainVoyager. This is a suite of software methods that are used in his publications as well as many others. Goebel has commercialized the software, which is widely used in science and clinical practice.

Research advances Rainer Goebel’s interest and expertise spans several subfields in the cognitive and psychological sciences, and his publication list demonstrates the high impact of his research in all of these subfields. Here I describe three aspects of his research that I find important and innovative. First, an important recurring topic in his research is related to the mapping of functional units in the human brain. These efforts are important, as mapping of functional units according to clear criteria is a precondition for identifying the interactions among them that form the basis of human cognition. These efforts started with methods for measuring the topographic organization of sensory cortex and parcellating sensory cortex based on topography (e.g., Formisano et al., Neuron, 2003), which now also has become possible in small subcortical structures thanks to improved fMRI spatial resolution (DeMartino et al., Nature Communications, 2013). Recently, using the ultra-high resolution capabilities at the MBIC, Goebel initiated research efforts to map

166 much smaller functional units, namely cortical columns and layers. The development of methods to identify small functional units in the living human brain will be the highest resolution analysis that has yet been achieved of the neural mechanisms of human cognition. Third, Goebel has been a leader in developing fMRI-based neurofeedback, which appears effective in remediating symptoms in specific psychiatric illnesses (e.g., depression, Linden et al., PLOSone, 2012) and motor deficits (Goebel et al., Imaging in medicine, 2010). FMRI neurofeedback is also being explored as a tool for communication with patients in a state of diminished consciousness or locked-in patients (e.g., Sorger et al., Current Biology, 2012; Narci et al., Annals of Neurology, 2012). The work on neurofeedback is now being explored in clinical trials (NCT01544205).

Leadership and mentorship I have witnessed Goebel’s leadership in several ways. In addition to being Chair of the Organization for Human Brain Mapping, he has been a first-rate group leader in his university. The Board of Maastricht University invested in a new neuroimaging center that Goebel heads. I have visited the Center, and I think Goebel has achieved an extraordinary center with world-class staff in Maastricht; the Maastricht Brain Imaging Center (MBIC) is so well-equipped and staffed that it easily places itself among the best centers worldwide.

Goebel is an outstanding mentor to many students and postdoctoral fellows. The technical capability of his students and colleagues will benefit the field of cognitive neuroscience for years to come.

Summary Rainer Goebel’s impact on the field has been positive, energetic, and much admired. He is an inspiring figure both in terms of the enthusiasm he displays when giving talks at conferences and in terms of the responsibilities he accepts in organizing the neuroimaging field. He is constantly receiving colleagues and traveling to help in setting up new research. Through the force of his personality and the impact of his tools, Goebel is having a major influence on the direction of the research in his field, and a major direct or indirect contributor to its success. He fulfills a high- profile leadership position in the field of psychological and cognitive science, making him very deserving of this prestigious award.

Sincerely,

Brian A. Wandell Director, CNI

Stein Family Professor

167 WELLCOME TRUST CENTRE FOR NEUROIMAGING jk (Inc LEOPOLD MULLER FUNCTIONAL IMAGING LABORATORY) ML 12 QUEEN SQUARE LONDON WC1N3BGUK

General S+44 (0)20 3 4484362 • Fax:+44 (0)20 7813 1445 • Principals S+44 (0)20 3 4484347 •http://www.fil.ion.ucl.ac.uk

To OHBM Council

20" February 2014

Dear OHBM Council,

Re: Nomination of Prof. Rainer Goebel for the OI-IBM Glass Brain Award It is my great pleasure to nominate Rainer Goebel forthe new OHBM Glass Brain Award. I know Rainerfor almost 15 years and have been collaborating with him inseveral cutting-edge neuroimaging projects. I have no doubt that his achievements make him a worthy recipient ofthis prestigious award. Rainer is strongly engaged in the neuroimaging community and is driving various activities ofthe OHBM. Forexample, he was chair ofthe OHBM, has organized scientific meetings and several workshops. In short. Rainer is one ofthe most active and eminent members ofthe neuroimaging community. He has very broadly contributed to the scientific progressand methods development in neuroimaging. To namejust a few; he developed various techniques for cortex-based fMRI analysis, real-time fMRI and Granger causality connectivity analysis (e.g., Roebroeck et al, Neuroimage 2005). Asa particular achievement he established the company Brain Innovation (Maastricht), which has been playing a central role in disseminating the latestanalysis methods and best practice in the neuroimaging community. Rainer is notonly a prolific methods developer, but also applies the latesttechnology to address fundamental issues in neuroscience. He made important contributions to the field of vision science such as the constructive nature of vision. He used innovative combinations of fMRI and TMS to study complex visuospatial mental imagery (e.g., Sacket al., Neuron 2002). He was also one of the very early adopters of ultra-high field MRI in cognitive neuroscience. His work on fine-grained tonotopy in the cortex is a cornerstone in the studies ofthe human auditory system (e.g., Formisano et al, Neuron 2003). These and otherseminal studies have shaped later studies inthe respective fields. He has been developing the high-resolution fMRI approach at ultra-high field further, which is perhaps the most exciting development in neuroimaging at the moment. For example, he has received a prestigious and highly competitive ERC Advanced Grant to develop and apply methods for fMRI at the columnar resolution and combine them with neurofeedback. Such a detailed and specific view and manipulation ofbrain activity would transform theway how we study the human brain. Rainer has an outstanding track record in mentoring and supervising young researchers. Many of his PhD students and postdocs have gone on and become renowned group leaders (e.g, E. Formisano, A. Sack, D. Linden. L. Muckli, N. Kriegeskorte, etc.). He is a brilliant teacher who regularly contributes to the teaching programs of the OHBM, ISMRM and other organizations. Ifind

Professor RJ Dolan FRS Professor G Rees Professor KJ Friston FRS Professor EAMaguire 168 Professor CJ Price Professor PR Montague it always impressive how Rainer instils enthusiasm in students and young researcher for our scientific field. This spirit is essential to keep our field alive and innovating.

It is needless to mention that Rainer brings all other credentials and esteem markers with him, which one would expect from an international leader in the field. He has secured several million Euros of funding, set up a ultra-high field MRI lab and is a well sought speaker, reviewer and adviser. He has published many papers in high impact journals such as Nature, PNAS or Neuron (h-index = 53).

On a personal note, I have always experienced Rainer as a friendly passionate researcher with an outstanding collaborative spirit. I have benefited from his generosity already as a PhD student working in the emerging field of real-time fMRI and neurofeedback. Without him the pioneering work in this field, which has developed into applications in clinical trials within less than 15 years, would have been impossible. He has recently developed an efficient spelling device based on real time fMRI, which is expected to transform how locked-in patients can communicate with the outside world (Sorger et al., CurrBiol. 2012). I would be delighted if you awarded Rainer the OHBM Glass Brain Award to recognize his excellent science, collaborative spirit and passion for both the neuroimaging community and the scientific questions.

I would like to thank you for the consideration. Please do not to hesitate to contact me ifyou have any questions.

Sincerely,

Dr. Nikolaus Weiskopf Head of Physics Senior Lecturer Tel. +44-20-3448-4381 Fax +44-20-7813-1420 [email protected]

Professor RJ Dolan FRS Professor G Rees Professor KJ Friston FRS Professor EA Maguire 169 Professor CJ Price Professor PR Montague James V. Haxby Evans Family Distinguished Professor Director, Center for Cognitive Neuroscience

My current research focuses on the development of computational methods for building models of representational spaces. We assume that distributed population responses encode information. Within a cortical field, a broad range of stimuli or cognitive states can be represented as different patterns of response. We use fMRI to measure these patterns of response and multivariate pattern (MVP) analysis to decode their meaning. We are currently developing methods that make it possible to decode an individual’s brain data using MVP classifiers that are based on other subjects’ data. We use a complex, natural stimulus to sample a broad range of brain representational states as a basis for building high-dimensional models of representational spaces within cortical fields. These models are based on response tuning functions that are common across subjects. Initially, we demonstrated the validity of such a model in ventral temporal cortex. We are working on building similar models in other visual areas and in auditory areas. We also plan to investigate representation of social cognition using this same conceptual framework.

170 Dick Passingham

BA Oxon First, MSc University of London, PhD University of London, FRS

Emeritus Professor of Cognitive Neuroscience

• Emeritus Principal (Wellcome Centre for NeuroImaging, UCL)

• Emeritus Fellow of Wadham College

Biography

Research Summary

I am interested in what is special about the human brain. This has led me to study the prefrontal cortex, in particular, and to do so both in non human primates and in human subjects. I have used a variety of methods including studying the effects of lesions, working with patients with particular neurological disorders, interfering with brain activity by transcranial magnetic brain stimulation, and recording activations in the brain using both PET and fMRI. The work has culminated in a new proposal concerning the fundamental function of the prefrontal cortex (Passingham and Wise ‘The Neurobiology of the Prefrontal Cortex’, 2012, OUP).

I am now devoting my time to writing books. I am currently working on a book called ‘The Uses and Misuses of Brain imaging’ (OUP). The aim of this is to serve as a primer for those starting out on brain imaging, telling them the sorts of mistake that it is easy to make and the ways in which imaging data can be misinterpreted.

171 Nomination for Glass Brain Award 2014. Stefan Posse, PhD

I'd like to nominate Dr. Stefan Posse for this lifetime achievement award in the field of human brain mapping:

With over 26 years of experience in biomedical MR research at institutions in the US, Germany and Switzerland, Dr. Posse serves as head of the MR research group in the Department of Neurology at University of New Mexico (http://hsc.unm.edu/som/neuro/lab/). The lab pioneered realtime functional MRI and highspeed MR spectroscopic imaging, and recently introduced highspeed realtime fMRI using multislab echovolumar imaging. The ultimate goal is to improve individualized treatment strategies and prognosis based upon patient specific functional brain mapping.

Dr. Posse obtained his undergraduate degree in Physics at the University of Cologne, Germany and pursued his PhD in Magnetic Resonance in vivo at the University of Florida and the University of Berne in Switzerland. During his postdoctoral training at the National Institutes of Health he developed MR methodology to investigate brain metabolism and function at high magnetic field, and introduced one of the first highspeed MR metabolic imaging methods in human brain. He subsequently moved to Germany to build an MR research laboratory at the Research Center Juelich and pioneered realtime functional MRI in human brain. In 2000, he joined Wayne State University School of Medicine in Detroit, MI, where he built a highfield MR research laboratory with one of the first clinical 4 Tesla whole body MR scanners. Since 2003, he is with the University of New Mexico School of Medicine. He is Professor in the Department of Neurology with secondary appointments in the Departments of Electrical and Computer Engineering, and Physics and Astronomy.

His federally funded research program is aimed at advancing functional and metabolic MRI for applications in Neuroscience and Clinical Research. He trains students, fellows, residents, faculty and staff to prepare them for successful careers in academia and industry. He serves frequently on NIH study sections and collaborates with national and international research centers in the United States and Europe.

172 In 2012, Dr. Posse cochaired a Symposium on Multimodal Imaging Techniques Targeted at Specific Brain Mechanisms at the European Winter Conference on Brain Research in Villars, Switzerland. He gave an invited talk at the Scientific Workshop on fMRI From Cortical Layers to Networks in WhistlerBlackcomb, BC. He gave invited lectures at the 20th Annual Meeting of the International Society of Magnetic Resonance in Medicine in Melbourne, Australia. He organized a morning workshop on ultrahighspeed fMRI at the 18th Annual Meeting of the Organization of Human Brain Mapping in Beijing, China. He gave an invited talk at the Third International Workshop on Hyperpolarized Carbon13 and its Applications in Metabolic Imaging. He lectured on realtime fMRI at the UCLA Advanced Neuroimaging Summer program.

Last year, Dr. Posse organized an Ancillary Meeting at the annual ISMRM in Salt Lake City, Utah: Recent advances in highspeed MRSI methodology for clinical research studies; and, in September, a Dynamic MR Spectroscopy Study Group Virtual ISMRM Meeting: MRSI in Clinical Practice – Reaching Consensus. Invited presentations were given at a Frontiers in Molecular Imaging Symposium in May, at UT Southwestern, Houston TX : New Windows into Brain Physiology using HighSpeed Functional and Spectroscopic MRI; and, at a “Realtime functional MRI” Workshop in October at Peking University, Chinese Academy of Sciences and Beijing Normal University, Beijing, China: Realtime Mapping of Functional Network Connectivity Dynamics using HighSpeed fMRI.

173 BIOGRAPHICAL SKETCH

NAME Stefan Posse, Ph.D. POSITION TITLE Professor

EDUCATION/TRAINING University of Cologne, Cologne, Germany Dipl.Phys. 19801986 Physics University of Berne, Berne, Switzerland Ph.D. 19871990 NMR in Biomedicine National Institute of Health, Bethesda, MD Postdoc 19911994 NMR in Biomedicine University of Duesseldorf, Duesseldorf, Germany Habilitation 19971999

Positions and Honors.

Positions and Employment 1990 – 1991 Postdoctoral Fellow, University of Berne, Berne, Switzerland 1991 – 1994 Fogarty Fellow, National Institutes of Health, Bethesda, MD 1994 – 1999 Head of the MR Research Group, Institute of Med, Research Center Jülich GmbH, Germany 1995 – 2011 Affiliate Assistant Prof, Department of Radiology, University of Washington, Seattle, WA 1999 – present Privatdozent (lecturer), Department of Physical Biology, University of Düsseldorf, Germany 1999 Staff Scientist, Dept. of Psychiatry, Rheinische Landeskliniken, Düsseldorf, Germany 1999 – 2000 Visiting Senior Research Scientist, Lab. of Functional Neuroimag., IRCCS Santa Lucia, Italy 2000 – 2003 Assistant Professor, Director of Functional Neuroimaging Laboratory, Dept. of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine 2001 – 2003 Scientific Director, Brain Imaging Research Division, Dept. of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine 2003 – 2003 Associate Professor with Tenure, Director of Functional Neuroimaging Laboratory, Dept. of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine 2003 – present Adjunct Associate Professor, Dept. of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine 2003 – 2005 Associate Professor, Dept. of Psychiatry, University of New Mexico 2003 – 2006 Director of MR Research, The MIND Imaging Center 2005 – 2008 Associate Professor with Tenure, Dept. of Psychiatry, University of New Mexico

174 2003 – 2010 Assoc. Professor, Dept. of Electrical and Computer Engineering, U. of New Mexico 2006 – 2011 Adjunct Associate Professor, Dept. of Physics, University of New Mexico 2008 – 2010 Associate Professor with Tenure, Dept. of Neurology, University of New Mexico 2011 – present Affiliate Assoc. Professor, Department of Radiology, University of Washington, Seattle, WA 2010 – present Professor with Tenure, Dept. of Neurology, University of New Mexico 2010 – present Professor, Dept. of Electrical and Computer Engineering, University of New Mexico 2011 – present Professor, Dept. of Physics and Astronomy, University of New Mexico

Honors & Awards Scholarship Swiss National Science Foundation, Berne, Switzerland, 1987 – 1992 Fellowship Fogarty International Center, National Institutes of Health, Bethesda, MD, 1991 1994 Finalist Young Investigator Award, Soc. of Magn. Reson., 1st Ann Meeting, San Francisco, CA, 1994 Editorial board member of Neuroimage Elsevier, 2011 2014

Selected peerreviewed publications (Publications selected from 88 peerreviewed publications) V.G. Kiselev, S. Posse, “Theory of Susceptibility induced NMR Signal Dephasing in a Cerebrovascular Network. ”, Physical Review Letters, 81:56965699, 1998. S. Posse, S. Wiese, D. Gembris, K. Mathiak, C. Kessler, M.L. GrosseRuyken, B. Elghawaghi, T. Richards, S. R. Dager, V. G. Kiselev, ”Enhancement of BOLDContrast Sensitivity by SingleShot MultiEcho Functional MR Imaging”, Magnetic Resonance in Medicine, 42 (1): 8797, 1999. D. Gembris, J.G. Taylor, S. Schor, W. Frings, D. Suter, S. Posse, ”Functional MR Imaging in RealTime using a slidingwindow correlation technique”, Magnetic Resonance in Medicine, 43: 259268, 2000 K. Mathiak, S. Posse, “Evaluation of Motion and Realignment for Functional Magnetic Resonance Imaging in Realtime”, Magnetic Resonance in Medicine, 45(1):167171, 2001 S. Posse, F. Binkofski, F. Schneider, D. Gembris, S. Wiese, V. Kiselev, T.Graf, B. Elghawaghi, T. Eickermann, “A New Approach to Measure Single Event Related Brain Activity using RealTime fMRI: Feasibility of sensory, motor, and higher cognitive tasks”, Human Brain Mapping, 12(1); 2541, 2001 S. Posse, L.J. Kemna, S. Wiese, B. Elghahwagi, V. G.Kiselev, “Dependence of fMRI Contrast on graded Hypo and Hypercapnia using Whole Brain T2*Mapping”, Magnetic Resonance in Medicine, 46, 264271, 2001 Posse, S., Shen, Z., Kiselev, V.G., Kemna, L.J., SingleShot T2* Mapping with 3D Compensation of Local Susceptibility Gradients in Multiple Regions, NeuroImage 2003 February, 18(2):390400. Posse, S., Fitzgerald, D., Gao, K., Habel, U., Rosenberg, D., Moore, G.J., Schneider, F., Realtime Functional Magnetic Resonance Imaging of Single Trial Amygdala Activation during SelfInduced Sadness, NeuroImage, 18, 760768, 2003. MartínezRamón M., Koltchinsky V., Verzi, S., Heileman, G., Posse, S., Optimal Aggregation of Classifiers and Boosted Maps in Multiclass Realtime fMRI Pattern Recognition, Neuroimage, 2006 Jul 1;31(3):112941

175 Mayer, A.R., Xu, J., ParaBlagoev, J., Posse, S., Reproducibility of Activation in Broca’s Area During Covert Generation of Single Words at High Field: A Single Trial FMRI Study at 4 Tesla, Neuroimage, 2006 Aug 1;32(1):12937 Otazo, R., Lin, F.H., Wiggins, G., Jordan, R., Sodickson, D., Posse, S., Superresolution Parallel Magnetic Resonance Imaging, Neuroimage, Volume 47, Issue 1, 1 August 2009, Pages 220230. Posse S. Multiecho acquisition. Neuroimage. 2011 Oct 25. [Epub ahead of print] PMID 22056458 Posse, S., Ackley, E., Mutihac, R., Rick, J., Shane, M., MurrayKrezan, C., Zaitsev, M., Speck, O. Enhancement of Temporal Resolution and BOLD Sensitivity in RealTime fMRI using MultiSlab Echo Volumar Imaging, NeuroImage 2012 May 15;61(1):11530. Epub 2012, Feb 28 Zheng, W., Ackley E., MartinezRamon, M., Posse, S., A spatially distributed aggregated pattern classifier for functional MRI, Magn Reson Imaging, 2013 Feb;31(2):24761. Posse, S., Ackley, E., Mutihac, R., Zhang, T., Hummatov, R., Akhtari, M., Chohan, M.O., Fisch, B., Yonas, H., HighSpeed RealTime Resting State fMRI using MultiSlab EchoVolumar Imaging. Front. Hum. Neurosci., 2013 Aug 26;7:479. doi: 10.3389/fnhum.2013.00479.

Selected Patents 13 issued patents, 5 patent applications under review Posse, S., Le Bihan, D., Method and System for Multidimensional Localization and for Rapid Magnetic Resonance Spectroscopic Imaging, United States Patent No. 5,657,758, August 19, 1997 Posse, S., Le Bihan, D., Method and System for Multidimensional Localization and for Rapid Magnetic Resonance Spectroscopic Imaging, United States Patent No. 5,709,208, January 20, 1998 Posse, S., Le Bihan, D., Method and System for Multidimensional Localization and for Rapid Magnetic Resonance Spectroscopic Imaging, United States Patent No. 5,879,299, March 9, 1999 Posse, S., Wiese, S.: Verfahren zum Betreiben eines Kernresonanztomographen mit einem Unterdruecken von Bildartefakten, German Patent No. 199 22 461.7, May 17, 2002 Posse, S., “MAGNETIC RESONANCE SPECTROSCOPY WITH SPARSE SPECTRAL SAMPLING AND INTERLEAVED DYNAMIC SHIMMING.” US Patent 7,683,614, March 23,2010 Posse, S., “MAGNETIC RESONANCE SPECTROSCOPY WITH REALTIME CORRECTION OF MOTION AND FREQUENCY DRIFT, AND REALTIME SHIMMING”, US Patent Application 12/931,196, allowed for issuance as a patent: September 12, 2013

176 Marcus E. Raichle, M.D.

Professor Radiology Neurology Anatomy and Neurobiology

Office Phone: 314-362-6915 Lab Phone: 314-362-7116 FAX: 314-362-6110 Mailing Address: Washington University School of Medicine East Building, Room 2116 4525 Scott Avenue St Louis, Missouri, 63110

Email: [email protected]

Marcus E. Raichle, a neurologist, is a Professor of Radiology, Neurology, Neurobiology and Biomedical Engineering at Washington University in St Louis. He is a member of the National Academy of Sciences, The Institute of Medicine and the American Academy of Arts and Sciences and a Fellow of the American Association for the Advancement of Science. He and his colleagues have made outstanding contributions to the study of human brain function through the development and use of positron emission tomography (PET) and functional magnetic resonance imaging (fMRI). Their landmark study (Nature, 1988) described the first integrated strategy for the design, execution and interpretation of functional brain images. It represented 17 years of work developing the components of this strategy (e.g., rapid, repeat measurements of blood flow with PET; stereotaxic localization; imaging averaging; and, a cognitive subtraction strategy). Another seminal study led to the discovery that blood flow and glucose utilization change more than oxygen consumption in the active brain (Science, 1988) causing tissue oxygen to vary with brain activity. This discovery provided the physiological basis for subsequent development fMRI and caused researchers to reconsider the dogma that brain uses oxidative phosphorylation exclusively to fuel its functional activities. Finally seeking to explain task-induced activity decreases in functional brain images they employed an innovative strategy to define a physiological baseline (PNAS, 2001; Nature Reviews Neuroscience, 2001). This has led to the concept of a default mode of brain function and invigorated studies of intrinsic functional activity, an issue largely dormant for more than a century. An important facet of this work was the discovery of a unique fronto-parietal network in the brain that has come to be known as the default network. This network is now the focus of work on brain function in health and disease worldwide. In summary, the Raichle group has consistently led in defining the frontiers of cognitive neuroscience through the development and use of functional brain imaging techniques.

177

Van Wedeen, MD Associate Professor of Radiology Massachusetts General Hospital and the Harvard Medical School Martinos Center for Biomedical Imaging Building 149 13th St, 2nd floor Charlestown, MA 02129 +1.617.678.7868 [email protected]

March 14, 2014

OHBM Council

Dear Sirs,

I would like to share with you my unreserved and most enthusiastic support for the nomination of Robert Turner for OHBM’s Lifetime Achievement “Glass Brain” Award.

Dr. Turner has been a leader in imaging for more than 30 years. His impact has been fundamental and remarkably, perhaps uniquely, broad. As on example, his creation in the mid-80s of the first actively shielded gradients is a typical example of his insight and forethought – not only was this step iconoclastic - deliberately reducing the efficiency of a gradient, or so it seemed, but this move had incalculable benefits for later biomedical imaging, specifically (but not limited to) fMRI, fast scanning and diffusion imaging, which he simultaneously pioneered. Let me not pass this by too quickly; if there was “golden age” in the creation of modern MRI brain mapping (maybe 1986-94), one would find that Bob played a central role in most or all of these critical developments. Had it not been for Bob’s contributions, brain mapping would now look quite different, and very much smaller and less interesting,

Over the span of his career, Bob has had an amazingly manifold role – inventor and creator of new methods; ingenious and innovative pioneer in applications; perhaps most important, leader in many debates on fundamental questions. In two topics I follow most closely, functional imaging and diffusion imaging, Bob consistently has been a voice of both passion and caution, inviting the community to think more deeply about our methods and results, and to consider alternative interpretations. His personal style and tone have set an example for intellectual rigor and clarity, joined with openness and collegiality, to the lasting benefit of the community.

178 As one recent example, in the spring of 2013, I attended with Bob an NSF-sponsored workshop in Alexandria VA in response to President Obama’s new Brain initiative. While many attendees advocated narrow agendas, Bob was eloquent for the need and opportunity to go beyond the frontiers of present approaches – for example, to continue the quest to map, for example electrical current sources, or the potential to map structure and connectivity with multiple mechanisms for new subtly and insight. I mention this because it demonstrates how Bob has been so effective as a leader – at once inclusive, visionary and concrete, and also to create the foundation for his deepest commitment, which I would say, and believe he would agree, has always been to teaching and the next generation.

Professor Turner has a unique place in our community, as physicist, inventor, biologist, psychologist, leader, humanist, and teacher. He has sustained these roles throughout his illustrious and productive career of over 4 decades. He is exceptionally deserving of this honor of OHBM’s lifetime achievement award, and I highly commend the OHBM for proposing it.

Yours respectfully,

179 FOR MAX HUMAN PLANCK COGNITIVE AND BRAIN SCIENCES INSTITUTE DEPARTMENT OF NEUROPHYSICS

MPI for Human Cognitive and Brain Sciences ! PO BOX 500 355 ! 04303 Leipzig, Germany

Organization for Human Brain Mapping 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 USA

Nomination of Robert Turner for the Glass Brain Award 2014

Leipzig, 14.03.2014 Dear OHBM Staff,

We hereby nominate Professor Robert Turner for the Glass Brain Award 2014. We strongly believe that Bob merits recognition from the HBM community for his contributions to the field. Furthermore, as 2014 is the year of his retirement, we feel that there is no better time point for a lifetime achievement award. Robert Turner has always been deeply interested in the relationship between brain and thought. Over 30 years ago, Bob Turner set out to determine whether magnetic resonance imaging (MRI) could be used to study the function and structure of the brain. He has spent the intervening years ensuring that the answer to his question was a resounding yes— pioneering hardware, methods, and applications to establish and refine MR techniques, which he and the majority of the community predominantly rely upon to investigate the human brain. From 1984 to 1988 Bob worked in the Nottingham MRI lab of the Nobel Prize winning Professor Sir Peter Mansfield. During that time, Bob developed an approach for designing high-strength gradient coils that enabled ultra-fast echo-planar imaging (EPI). Bob’s efforts earned him the role of primary inventor of a patent that, in the words of Mansfield, “forms the basis of all commercial MRI machines today” [Sir Peter Mansfield – Autobiography. Nobelprize.org]. Consequently, the method, known as the "target field method" [Turner. J Phys D Appl Phys 1986], was adopted by all major MRI scanner manufacturers and by 1992 clinical MRI scanners capable of ultra-fast echoplanar imaging (EPI) became widely available. This opened the way forward for effective MRI study of changes in brain activity taking place over short time scales.

Dr. Robert Trampel Stephanstraße 1A Tel. ++49(0)341 9940-2293 [email protected] Research Staff 04103 Leipzig, Germany Fax ++49(0)341 9940-2448 www.cbs.mpg.de

180 FOR MAX HUMAN PLANCK COGNITIVE AND BRAIN SCIENCES INSTITUTE DEPARTMENT OF NEUROPHYSICS

In 1988, Robert Turner continued on to the USA's National Institutes of Health where he further developed EPI. Furthermore, he designed, constructed and installed the first local gradient coil suitable for human brain imaging. As a result, EPI was implemented for the first time on an otherwise standard clinical scanner. Working with Denis Le Bihan, Robert Turner initially showed that EPI could be used to provide high quality maps of water diffusion in brain tissue [Turner et al. Radiology 1990], a discovery (known as Diffusion MRI), which has led to the widespread clinical use of MRI in stroke. The technique also lies at the heart of diffusion-weighted imaging (DWI), a method for non-invasive study of connecting pathways within the brain’s white matter. In 1991, Bob‘s cat brain studies of hypoxia showed for the first time that EPI could be used to monitor the time course of oxygenation changes in animal brain [Turner et al. Magn Reson Med 1991]. This led to the discovery that EPI could non-invasively track, within seconds, the local changes in blood oxygenation (BOLD) in human brain caused by task-related neural activity. In 1992, two equally seminal papers by Kenneth Kwong et al. [PNAS 1992] (of which Bob is a co-author) and Seiji Ogawa et al. [PNAS 1992] appeared, showing similar results demonstrating that BOLD contrast enables the mapping of activation patterns in the working human brain. These findings provided the foundation for functional MRI (fMRI) as it is used today and the subsequent development of what has come to be known as Imaging Neuroscience. After the stage was set for neuroscientific studies, Bob started working closely with other distinguished neuroscientists, including Leslie Ungerleider, Denis Le Bihan, Tim Pons, Helen Neville, and Daphne Bavelier. Numerous groundbreaking papers resulted from these collaborations. One such paper demonstrated neural plasticity in the primary motor cortex as a result of daily training [Karni et al. Nature 1995]. Bob also collaborated to demonstrate that visualization tasks can activate primary visual cortex [Le Bihan et al. PNAS 1993] and, similarly, motor ideation can activate primary motor cortex [Leonardo et al. Hum Brain Mapp 1995]. In another paper, brain areas used by congenitally deaf people for reading American Sign Language and written English were investigated by means of BOLD-fMRI [Neville et al. PNAS 1998]. In 1993, Robert Turner moved to the Institute of Neurology, London, as a founding member of the Wellcome Department of Cognitive Neurology (now the Wellcome Centre for Imaging Neuroscience). Awarded a Wellcome Trust Principal Research Fellowship, he set about the task of transforming functional MRI from a curiosity to a practical tool for investigating the functional organization of the living human brain. With Bob as the head of MRI at the Wellcome Trust, the Functional Imaging

Dr. Robert Trampel Stephanstraße 1A Tel. ++49(0)341 9940-2293 [email protected] Research Staff 04103 Leipzig, Germany Fax ++49(0)341 9940-2448 www.cbs.mpg.de

181 FOR MAX HUMAN PLANCK COGNITIVE AND BRAIN SCIENCES INSTITUTE DEPARTMENT OF NEUROPHYSICS

Laboratory (FIL) rapidly became the world leader in imaging neuroscience. The techniques developed during Bob’s tenure for experimental design, data acquisition and analysis have been almost universally adopted. As the senior physicist in this grouping, Bob ensured that the novel analysis techniques, mostly devised by Karl Friston, were properly adapted to the nature of fMRI data, and could do full justice to the data quality [Friston, Jezzard & Turner. Hum Brain Mapp 1994; Friston et al. Neurimage 1995]. Besides steering fMRI data analysis strategies at the FIL to enable reliable and statistically valid functional localization, Bob directed many technical innovations in MRI and fMRI methodology [Deichmann et al. Neuroimage 2003; Deichmann, Schwarzbauer & Turner. Neuroimage 2004], maximizing the sensitivity and productivity of the MRI scanners, but also in the combination of fMRI with EEG [Allen, Josephs & Turner. Neuroimage 2000]. Furthermore, Bob always reminded the community of the virtues and pitfalls of BOLD imaging by further investigating the underlying principles [Turner. Neuroimage 2002]. During his three-month stay as a Visiting Professor at Kyoto University in 2003, he participated in seminal studies on the neuroscience of music [Callan et al. Neuroimage 2006] and language [Crinion et al. Science 2006]. In 2006, Robert Turner was appointed Director at the Max-Planck-Institute for Human Cognitive and Brain Sciences in Leipzig. He established the Department of Neurophysics and installed a high-performance 7 T MRI scanner. Here, Bob lifted MRI to an unprecedented level of spatial resolution for both structural [Leuze et al. Cereb Cortex 2014] and functional imaging [Heidemann et al. Magn Reson Med 2012]. He immediately understood that the 7 T data necessitate new analysis techniques, since the established methods would not be able to do full justice to the high spatial resolution and high signal-to-noise provided by the ﬁeld strength of 7 Tesla [Lohmann et al. Brain Connect 2013]. Furthermore, Gabriele Lohmann and Bob Turner developed new techniques for analyzing connectivity patterns in the human brain [Lohmann et al. PLoS One 2010; Lohmann et al. Front Syst Neurosci 2012]— highly relevant for the search for the human connectome—and challenged existing methods for interpreting functional neuroimaging data [Lohmann et al. Neuroimage 2012]. Bob also realized that future studies of human brain function can only be successful if they are based on anatomy and pushed the idea forward to discriminate specific cortical areas by their anatomical signatures. He has combined histological staining methods, and recently, proton induced X-ray emission [Stüber et al. Neuroimage, in press], to elucidate the neural correlates of inherent MRI contrast. Following the work of Bob‘s group [Geyer at al. Front Hum Neurosci 2011] and the

Dr. Robert Trampel Stephanstraße 1A Tel. ++49(0)341 9940-2293 [email protected] Research Staff 04103 Leipzig, Germany Fax ++49(0)341 9940-2448 www.cbs.mpg.de

182 FOR MAX HUMAN PLANCK COGNITIVE AND BRAIN SCIENCES INSTITUTE DEPARTMENT OF NEUROPHYSICS lab of David van Essen [Glasser & Van Essen. J Neurosci 2011], the idea of “in vivo Brodmann mapping“ has become a large focus in the community. Remarkably, during all that time as an imaging neuroscientist, Robert Turner never forgot about the “inner physicist,“ by pushing highly sophisticated technical developments necessary for simplifying brain imaging at 7 Tesla [Kozlov & Turner. J Magn Reson 2009]. After his retirement in February 2014, he will continue to contribute to the field of neuroscience as an Honorary Professor at the Universities of Leipzig and Nottingham. It is fair to say that without the work and determination of Professor Robert Turner imaging neuroscience would not be possible the way as we know it today. The fact, that he not only applied imaging techniques to answer highly relevant neuroscience questions, but also played a key in role in developing the tools which we use every day, makes him outstanding and unique within the HBM community. Even more so, as those tools range from sophisticated analysis techniques, to fundamental imaging modalities, to the basic principles of MRI scanners. Bob has taught us to continually question the status quo. In fact, probably not a single OHBM member ever presented a talk an annual meeting without receiving a question from Bob Turner. His questions serve to remind us of the work that has built our community, to help inspire our future directions, and to encourage and praise good science and the spirit of collaboration within our community. While the HBM community has been built by the lifetime achievements of many prominent members, the year 2014 marks the retirement of one of those individuals. Honoring Robert Turner this year with the Glass Brain Award, would be the ultimate salute to a man that has dedicated his life to pushing the frontiers of neuroscience and would give him the recognition he definitely deserves.

Sincerely,

Dr. Debra Rivera Dr. Andreas Schäfer Dr. Robert Trampel

Dr. Robert Trampel Stephanstraße 1A Tel. ++49(0)341 9940-2293 [email protected] Research Staff 04103 Leipzig, Germany Fax ++49(0)341 9940-2448 www.cbs.mpg.de

183 FOR MAX HUMAN PLANCK COGNITIVE AND BRAIN SCIENCES INSTITUTE DEPARTMENT OF NEUROPHYSICS

Attachment 1: Curriculum Vitae of Robert Turner

Dr. Robert Trampel Stephanstraße 1A Tel. ++49(0)341 9940-2293 [email protected] Research Staff 04103 Leipzig, Germany Fax ++49(0)341 9940-2448 www.cbs.mpg.de

184 FOR MAX HUMAN PLANCK COGNITIVE AND BRAIN SCIENCES INSTITUTE DEPARTMENT OF NEUROPHYSICS

Curriculum Vitae

Education 1964 - 1968 Mathematics and Physics at Cornell University, N.Y., USA (B.A. magna cum laude) 1968 - 1972 Physics at Simon Fraser University, Vancouver, Canada (Ph.D.) 1975 - 1977 Social Anthropology at University College, London (Post-graduate diploma)

Career 1967 - 1968 Laboratory Technician, Low Temperature Physics, Cornell University, Ithaca, NY, USA 1968 - 1972 Teaching Assistant, Department of Physics, Simon Fraser University, Vancouver, Canada 1972 - 1975 Research Assistant, Cavendish Laboratory, Physics Department, Cambridge University, UK 1977 - 1980 Research Fellow, Department of Social Anthropology, University of Edinburgh, UK 1980 - 1984 Lecturer in Physics, Napier College, Edinburgh, UK 1984 - 1988 Lecturer in Physics, University of Nottingham, Nottingham, UK 1988 - 1991 Visiting Scientist, NCRR/BEIP, NIH, Bethesda, Maryland, USA 1991 - 1993 Visiting Scientist, Lab of Cardiac Energetics, NHLBI, NIH, Bethesda, Maryland, USA 1993 - 2003 Wellcome Principal Research Fellow, and Professor, Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, UK 1997 - 2002 Adjunct Associate Professor, Georgetown University, Washington DC, USA 2001 - 2006 Honorary Professor, Department of Medical Physics and Bioengineering, University College London, London, UK

Dr. Robert Trampel Stephanstraße 1A Tel. ++49(0)341 9940-2293 [email protected] Research Staff 04103 Leipzig, Germany Fax ++49(0)341 9940-2448 www.cbs.mpg.de

185 FOR MAX HUMAN PLANCK COGNITIVE AND BRAIN SCIENCES INSTITUTE DEPARTMENT OF NEUROPHYSICS

2001 - 2006 Co-Director, Wellcome Trust High Field Magnetic Resonance Research Laboratory, Department of Medical Physics, University College London, London, UK 2003 Visiting Professor of Neurophysiology, Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan 2003 - 2006 Professor and Principal University Technologist, Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK 2006 - 2014 Director, Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany Since 2009 Honorary Professor, Faculty of Physics and Earth Sciences, University of Leipzig, Germany Since 2013 Honorary Professor, School of Physics and Astronomy, The University of Nottingham, Nottingham, UK

Selected publications, and patents: Author of over 170 refereed articles in the fields of neurophysics, physics, anthropology and music, Turner has a h-index of approximately 50. His work has also resulted in several patents for coils used in imaging.

Selected publications: Turner R. (1986). A target field approach to optimal coil design. Journal of Physics D: Applied Physics 19:L147-51. Turner R, Le Bihan D, Maier J, Vavrek R, Hedges LK, Pekar J. (1990). Echo-planar imaging of intravoxel incoherent motion. Radiology 177:407-14. Stehling MK, Turner R, Mansfield P. (1991). Echo-planar imaging: magnetic resonance imaging in a fraction of a second. Science 254:43-50. Turner R, Le Bihan D, Moonen CTW, Despres D, Frank J. (1991). Echo-planar time course MRI of cat brain deoxygenation changes. Magnetic Resonance in Medicine 22:159-66. Kwong KK, Belliveau JW, Chesler DA, Goldberg IE, Weisskoff RM, Poncelet BP, Kennedy DN, Hoppel BE, Cohen MS, Turner R, Cheng HM, Brady TJ, Rosen

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186 FOR MAX HUMAN PLANCK COGNITIVE AND BRAIN SCIENCES INSTITUTE DEPARTMENT OF NEUROPHYSICS

BR. (1992). Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. Proceedings of the National Academy of Sciences USA 89:5675-9. Turner R, Jezzard P, Wen H, Kwong KK, Le Bihan D, Zeffiro T, Balaban RS. (1993). Functional mapping of the human visual cortex at 4 tesla and 1.5 tesla using deoxygenation contrast EPI. Magnetic Resonance in Medicine 29:277-9. Le Bihan D, Turner R, Zeffiro TA, Cuenod CA, Jezzard P, Bonnerot V. (1993). Activation of human primary visual cortex during visual recall - a magnetic resonance imaging study. Proceedings of the National Academy of Sciences USA 90:11802-5. Friston KJ, Jezzard P, Turner R. (1994). The analysis of functional MRI time series. Human Brain Mapping 1:153-71. Leonardo M, Fieldman J, Sadato N, Campbell G, Ibanez V, Cohen L, Deiber M P, Jezzard P, Pons T, Turner R, Le Bihan D, Hallett M. (1995). A functional magnetic resonance imaging study of cortical regions associated with motor task execution and motor ideation in humans. Human Brain Mapping 3:83-92. Friston KJ, Holmes AP, Poline JB, Grasby PJ, Williams SCR, Frackowiak RSJ, Turner R. (1995). Analysis of fMRI time-series revisited. Neuroimage 2:45-53. Karni A, Meyer G, Jezzard P, Adams MM, Turner R, Ungerleider LG. (1995). Functional MRI evidence for adult motor plasticity during motor skill learning. Nature 377:155-8. Friston KJ, Williams S, Howard R, Frackowiak RSJ, Turner R. (1996). Movement- related effects in fMRI time-series. Magnetic Resonance in Medicine 35:346-55. Karni A, Meyer G, Rey-Hipolito C, Jezzard P, Adams MM, Turner R, Ungerleider LG. (1998). The acquisition of skilled motor performance: fast and slow experience-driven changes in primary motor cortex. Proceedings of the National Academy of Science USA 95:861-8. Friston KJ, Fletcher P, Josephs O, Holmes A, Rugg MD, Turner R. (1998). Event- related fMRI: characterizing differential responses. Neuroimage 7:30-40. Neville HJ, Bavelier D, Corina D, Rauschecker JP, Karni A, Lalwani A, Braun A, Clark V, Jezzard P, Turner R. (1998). Cerebral organization for language in deaf and hearing subjects: biological constraints and effects of experience. Proceedings of the National Academy of Science USA 95:922-9.

Dr. Robert Trampel Stephanstraße 1A Tel. ++49(0)341 9940-2293 [email protected] Research Staff 04103 Leipzig, Germany Fax ++49(0)341 9940-2448 www.cbs.mpg.de

187 FOR MAX HUMAN PLANCK COGNITIVE AND BRAIN SCIENCES INSTITUTE DEPARTMENT OF NEUROPHYSICS

Friston KJ, Josephs O, Rees G, Turner R. (1998). Nonlinear event-related responses in fMRI. Magnetic Resonance in Medicine 39:41-52. Allen PJ, Josephs O, Turner R. (2000). A method for removing imaging artefact from continuous EEG recorded during functional MRI. Neuroimage 12:230-9. Turner R. (2002). How much cortex can a vein drain? Downstream dilution of activation-related cerebral blood oxygenation changes. Neuroimage 16:1062-7. Deichmann R, Gottfried JA, Hutton C, Turner R. (2003). Optimized EPI for fMRI studies of the orbitofrontal cortex. Neuroimage 19:430-41. Deichmann R, Schwarzbauer C, Turner R. (2004). Optimisation of the 3D MDEFT sequence for anatomical brain imaging: Technical implications at 1.5 and 3 T. Neuroimage 21:757-67. Callan DE, Tsytsarev V, Hanakawa T, Callan AM, Katsuhara M, Fukuyama H, Turner R. (2006). Song and speech: Brain regions involved with perception and covert production. NeuroImage 31:1327-42. Crinion J, Turner R, Grogan A, Hanakawa T, Noppeney U, Devlin JT, Aso T, Urayama S, Fukuyama H, Stockton K, Usui K, Green DW, Price CJ. (2006). Language control in the bilingual brain. Science 3121537-40. Turner R, Whitehead C. (2008). How collective representations can change the structure of the brain. Journal of Consciousness Studies 15:43-57. Kozlov M, Turner R. (2009). Fast MRI coil analysis based on 3-D electromagnetic and RF circuit co-simulation. Journal of Magnetic Resonance 200:147-52. Duque JFD, Turner R, Lewis ED, Egan G. (2010). Neuroanthropology: a humanistic science for the study of the culture-brain nexus. Social Cognitive and Affective Neuroscience 5:138-47. Lohmann G, Margulies DS, Horstmann A, Pleger B, Lepsien J, Goldhahn D, Schloegl H, Stumvoll M, Villringer A, Turner R. (2010). Eigenvector centrality mapping for analyzing connectivity patterns in FMRI data of the human brain. PLoS One 5:e10232. Geyer S, Weiss M, Reimann K, Lohmann G, Turner R. (2011). Microstructural parcellation of the human cerebral cortex – from Brodmann's post-mortem map to in vivo mapping with high-field magnetic resonance imaging. Frontiers in Human Neuroscience 5:19.

Dr. Robert Trampel Stephanstraße 1A Tel. ++49(0)341 9940-2293 [email protected] Research Staff 04103 Leipzig, Germany Fax ++49(0)341 9940-2448 www.cbs.mpg.de

188 FOR MAX HUMAN PLANCK COGNITIVE AND BRAIN SCIENCES INSTITUTE DEPARTMENT OF NEUROPHYSICS

Lohmann G, Ovadia-Caro S, Jungehülsing GJ, Margulies DS, Villringer A, Turner R. (2012). Connectivity concordance mapping: a new tool for model-free analysis of FMRI data of the human brain. Frontiers in Systems Neuroscience 6:13. Lohmann G, Erfurth K, Müller K, Turner R. (2012). Critical comments on dynamic causal modelling. Neuroimage 59:2322-9. Lohmann G, Stelzer J, Neumann J, Ay N, Turner R. (2013). "More is different" in functional magnetic resonance imaging: a review of recent data analysis techniques. Brain Connectivity 3:223-39. Leuze C, Anwander A, Bazin PL, Dhital B, Stüber C, Reimann K, Geyer S, Turner R. (2014). Layer-specific intracortical connectivity revealed with Diffusion MRI. Cerebral Cortex 24:328-39. Stüber C, Morawski M, Schäfer A, Labadie C, Leuze C, Streicher M, Barapatre N, Reimann K, Geyer S, Spemann D, Turner R. (in press). Myelin and iron concentration in the human brain: A quantitative study of MRI contrast. Neuroimage.

Patents: Turner R. Optical reconstruction of NMR images. UK Patent Application 8508154, 28th March 1985. Mansfield P, Turner R, Chapman BLW, Bowley RM. Magnetic field screens. UK Patent Application 8622277, 20th September 1985. US Patent 4,978,920, awarded December 18, 1990 Turner R, Mansfield P, Chapman BLW. Magnetic field coils. UK Patent Application 8714434, 28th June 1986. US Patent 4,896,129, awarded 23rd June 1990. Turner R. Minimum inductance coils. UK Patent Application 8729037, 11th December 1987. US Patent 5,289,151, awarded 22nd February 1994. Le Bihan D, Chen C-N, Levin RL, and Turner R. Apparatus for hyperthermia treatment of cancer. US Patent Application 07/435,661. 22nd November 1989 US Patent 5,284,144, awarded 8th February 1994. Hoult DI and Turner R. Rapid establishment of current in an inductor. US Patent Application, 1989. Vavrek R, Schaefer DJ, Myers CC, McFarland TG, Turner R. Local gradient coil. US Patent 5185576, Priority Date 12th August 1991

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189 FOR MAX HUMAN PLANCK COGNITIVE AND BRAIN SCIENCES INSTITUTE DEPARTMENT OF NEUROPHYSICS

Ivanov D, Turner R. MRI slice selection of distinct chemical species. European Patent Application. Priority Date February 2009 Kozlov M, Turner R. Method for optimization of a multi-channel coil. European Patent Application. Priority Date, 8th September 2009 Siegert T, Schulz J, Turner R, Reimer E. Within-bore-Embedded Tracking System for Motion Correction in MRI. European Patent Application. Priority Date October 2009

OHBM Conferences Organized and Sessions Chaired: 1996 - 1997 Officer of the OHBM 2001 Treasurer, Organizing Committee, International Conference on Human Brain Mapping, Brighton, UK 2002 Session Chair, International Conference on Human Brain Mapping, Sendai, Japan 2010 Co-Chair, Morning Workshop, "Prospects for In-vivo Microstructural Parcellation of Human Cortex", International Conference on Human Brain Mapping, Barcelona, Spain.

Reviewer for Scientific Journals: More than 25 journals, including Science, Nature, Nature Neuroscience, Brain, Journal of Neuroscience, Neuron, Proceedings of the National Academy of Sciences USA, Proceedings of the Royal Society, NeuroImage, Journal of Cerebral Blood Flow and Metabolism, New England Journal of Medicine, Magnetic Resonance in Medicine, Journal of Computer Assisted Tomography, Medical Physics, Journal of Magnetic Resonance Imaging, Magma, Radiology, Measurement Technology, Journal of Neuroradiology, Human Brain Mapping.

Dr. Robert Trampel Stephanstraße 1A Tel. ++49(0)341 9940-2293 [email protected] Research Staff 04103 Leipzig, Germany Fax ++49(0)341 9940-2448 www.cbs.mpg.de

190 FOR MAX HUMAN PLANCK COGNITIVE AND BRAIN SCIENCES INSTITUTE DEPARTMENT OF NEUROPHYSICS

Attachment 2: Supporting Letters by

- Richard Bowtell, University of Nottingham, Nottingham, UK - Jeff Duyn, National Institutes of Health, NINDS, Bethesda MD, USA - David Feinberg, University of California Berkeley, Berkeley CA, USA - Gary Glover, Stanford University, Stanford CA, USA - Jürgen Hennig, University Medical Center Freiburg, Freiburg, Germany - Peter Jezzard, University of Oxford, Oxford, UK - Seong-Gi Kim, University of Pittsburgh, Pittsburgh PA, USA - Kenneth Kwong, Harvard Medical School, MGH, Charlestown MA, USA - Nikos Logothetis, Max Planck Institute BC, Tübingen, Germany - Gabriele Lohmann, Max Planck Institute BC, Tübingen, Germany - Daniel Margulies, Max Planck-Institute CBS, Leipzig, Germany - Ravi Menon, Western University, RRI, London ON, Canada - Peter Morris, University of Nottingham, Nottingham, UK - Geraint Rees, University College London, ICN, London, UK - Robert Shulman, Yale University, New Haven CT, USA - Oliver Speck, Otto-von-Guericke-University, Magdeburg, Germany - Lawrence Wald, Harvard Medical School, MGH, Charlestown MA, USA - Van Weeden, Harvard Medical School, MGH, Charlestown MA, USA

Dr. Robert Trampel Stephanstraße 1A Tel. ++49(0)341 9940-2293 [email protected] Research Staff 04103 Leipzig, Germany Fax ++49(0)341 9940-2448 www.cbs.mpg.de

191 School of Physics & Astronomy th 14 March 2014 University Park Nottingham NG7 2RD Council of the Organization for Human Tel +44(0)115 951 514737 Brain Mapping Fax +44(0)115 951 515166

Email [email protected] www.nottingham.ac.uk/physics

Dear OHBM Council Members,

We write in support of the nomination of Professor Robert Turner for the OHBM Glass Brain Award for a lifetime of achievement in the field of human brain mapping. Bob Turner is a true pioneer in human brain mapping, who has made outstanding contributions to the technology and methodology that underpin brain mapping via magnetic resonance imaging, as well as leading the way in the exploitation of this approach.

While working in Nottingham in the 1980’s, Bob established the theoretical framework needed for the design of shielded magnetic field gradient coils. His seminal papers on this topic are widely cited and his ‘target field approach’ was to dominate gradient design for many years. Shielded gradients are essential for successful implementation of fMRI and especially for diffusion tensor imaging; they are now ubiquitous. Following his move to the NIH, Bob made key contributions to the development and implementation of diffusion-weighted imaging, and played a leading role in the development of fMRI, providing a demonstration of BOLD contrast in cat brain during hypoxia in 1991 and as a co-author of Ken Kwong’s seminal 1992 PNAS paper, which demonstrated BOLD-based human brain mapping. Subsequently Bob led the imaging physics group at the FIL in Queens Square during its highly productive formative years, making many highly acclaimed contributions to our understanding of the physiology of BOLD contrast and its use in investigating human brain function. In 2006, Bob took on the challenge of developing human brain mapping at ultra-high field following his appointment as a Director of the MPI for Human Cognitive and Brain Sciences in Leipzig. In this role, he has pioneered the mapping of functional domains based on the sensitivity of high resolution anatomical images to myelin. His tenure saw the solution of many issues related to human brain mapping at ultra-high field: the design of transmit arrays to overcome radiofrequency field inhomogeneity, motion correction and layer sensitive fMRI to mention but a few.

Without Bob’s contributions, human brain mapping would not be in the advanced state in which it finds itself today. His sustained contributions to the field, from its very inception, fully justify the Lifetime Achievement Award.

Yours faithfully

Professor Richard Bowtell, Professor Peter Morris Head of School of Physics and Astronomy Head of SPMMRC

192 DEPARTMENT OF HEALTH & HUMAN SERVICES National Institutes of Health National Institute of Neurological Disorders and Stroke

Building 10, Room B1D724

Phone: 301-594-7305 Fax: 301-480-2558 Email: [email protected]

DATE: March 10, 2014

TO: OHBM Council, Award Committee Organization for Human Brain Mapping, Minneapolis, Minnessota; USA

FROM: Dr. Jeff Duyn, Chief, AMRI, LFMI, NINDS National Institutes of Health, Building 10, Room B1D724, 9000 Rockville Pike, Bethesda MD 20892

SUBJECT: Award Nomination of Robert Turner

Dear Members of the Award Committee,

It is a pleasure to write this recommendation letter for my collegue Dr. Robert Turner, a renowned scientist in the field of Neuroimaging. I strongly support his nomination for the prestigious Glass Brain Award of the Organization for Human Brain Mapping. In fact, I can say with confidence that Dr. Turner’s ontributions to the field of Neuroimaging are outstanding and collectively are matched by very few researchers worldwide. His receiving this award will be timely and very well deserved.

Dr. Turner’s contributions to Neuroimaging started in the early eighties while he was involved in the development of the first MRI scanners. This was the time when MRI was still in its infancy, when many of the techniques used Today were still to be discovered. Amazingly, most of the techniques that proved useful for Neuroscience research have in some way benefited from Dr. Turner’s scientific insights and contributions.

One of his first major contributions was the design of gradient coils used for spatial localization, critical for rapid image acquisition. In fact, the rapid gradients that later (in the early nineties) proved critical for fMRI heavily leaned on Dr. Turner’s design approach.

Soon after, Dr. Turner was involved in the first diffusion weighted MRI experiments, were his gradients again were a critical element of making the experiment possible in humans. This then led to diffusion MRI becoming widely accepted in the community, first as an important tool for clinical diagnosis, and then as an investigative tool to study the brains fiber tracts.

Yet another important contribution was his work on the effect of blood oxygenation changes on MRI image contrast. Dr. Turner was one of the first to demonstrate blood oxygen level dependent (BOLD) brain changes during hypoxia, which laid the groundwork for the development of BOLD fMRI. In fact, Dr. Turner collaborated on the very first human BOLD fMRI experiments performed by the group at MGH led by Ken Kwong, lending his experitise in MRI and his understanding of the

193 physiology underlying the BOLD contrast mechanism based on the hypoxia experiments. It is difficult to overstate the importance of this development for functional Neuroimaging research.

Over the course of his research career that by now spans over thrity years, Dr. Turner has remained productive, as evidenced by his major contributions to the recent development of high field MRI. It is well recognized that Robert been instrumental in expoiting the advantages of high field to improve image resolution and contrast, and apply these to answer important neuroscientific questions. Notable accomplishement in this area are his correlative work comparing cortical function and laminar structure in various brain regions, including the visual and motor cortices. His group is currently at the forefront of expanding this approach to the entire brain, and I have no doubt that this again will lead to a major step forward in revealing its inner workings.

Sincerely,

Dr. Jeff Duyn Chief, Advanced MRI Section NINDS, NIH

2 194 UNIVERSITY OF CALIFORNIA, BERKELEY

BERKELEY • DAVIS • IRVINE • LOS ANGELES • RIVERSIDE • SAN DIEGO • SAN FRANCISCO SANTA BARBARA • SANTA CRUZ

HELEN WILLS NEUROSCIENCE INSTITUTE PHONE: (510) 642-2593 UNIVERSITY OF CALIFORNIA, BERKELEY FAX: (510) 642-3192 3 Barker Hall BERKELEY, CALIFORNIA 94720-3190

February 12, 2014

To Awards Committee members,

I am writing in support of the nomination of Robert Turner for the lifetime achievement award, the Glass Brain Award, in human brain mapping. Professor Turner has had a major impact on human brain mapping through his work as a physicist on MRI hardware, pulse sequences and contrast mechanisms of diffusion and BOLD introduced into echo planar imaging (EPI). With these new tools, Bob Turner has made fundamental contributions to our understanding of dynamic signal changes in the brain due to deoxyhemoglobin changes soon followed by the first BOLD fMRI imaging.

My work in MRI physics, pulse sequences and human brain imaging over the last 30 years gives me sufficient knowledge to discuss Bob Turner’s work and achievements. I have known Bob since 1989 when we met at a diffusion-perfusion MRI workshop in Philadelphia. We were independently developing diffusion weighted echo planar imaging (EPI), with my work then introducing the twice refocused spin echo diffusion encoding scheme, and our common interest in the ‘fly-back’ EPI trajectory to remove ghost artifact and this led to our research collaboration. Bob at this time was working with Denis LeBihan at N.I.H. Bob presented the first quantitative measurements of diffusion attenuation using single-shot EPI to tremendously reduce physiological noise from CSF and other sources. The gradient hardware and EPI pulse sequence designs on which this diffusion work was based, were no less directly the result of Dr. Turner’s immense contributions. Bob had earlier substantially contributed to the design of shielded gradient coils in Sir Peter Mansfields laboratory in Nottingham England, where he also worked with Rodger Ordidge to optimize the ‘blipped’ phase encoding scheme in SE-EPI (MBEST) sequence. Both the improved gradient design to reduce eddy currents and EPI design are essential to the diffusion-EPI technology. The resulting EPI based quantitiative diffusion measurements in human brain overcame major limitations from artifacts and physiological CSF pulsation noise present in diffusion imaging up until Bob’s introduction of diffusion-EPI, therefore, the majority of diffusion based brain mapping is dependent on this innovation by Dr. Turner. It can be mentioned that the goals and purpose of his pulse sequence development was for a different direction than structural brain mapping; instead it was for separating diffusion and perfusion attenuations to improve CBF perfusion measurements using the eventually abandoned IVIM model. Nevertheless the technique of diffusion encoding with EPI became, within only a few years, essential to the development of DTI by Peter Basser and others at NIH, and eventually for nearly all fibertrack imaging of brain white matter tracks, hence diffusion-EPI has become one of the most important and prolifically used tools for human brain mapping. It is not uncommon for highly advanced imaging tool and novel pulse sequence find great value in diverse areas, as serendipity can contribute to transformative technology and major discoveries.

Dr. Turner’s greatest strengths as a highly innovative scientist is his intellectual drive and his ability to overcome significant challenges in MRI and to overcome major problems in human brain imaging. Concurrent with his diffusion EPI developments, Dr Turner introduced T2* weighted EPI time series measurements to study blood oxygenation changes in cat brain and this clearly showed signal changes of very high importance. He collaborated with the MGH group and contributed to the optimization of EPI used in the first BOLD based functional MRI experiments conducted by Ken Kwong. Therefore Dr. Turner is also an author on this now basic approach to functional brain imaging (Kwong et al, P.N.A.S. 1992) through which EPI became a transformed and disruptive technology. Indeed, T2* weighted EPI has remained the workhorse for cognitive

195 psychology and neuroscience based fMRI brain mapping and more recent functional connectivity mapping. In summary it was Bob Turner’s broad understanding and innovations in MRI physics, his pioneering work and involvement in neuroscience challenges, no less his very friendly nature and skills at communicating and working with other talented scientists, that has allowed him to accomplish two of the most important MRI approaches to human brain mapping.

As Director of the Max Planck Institute in neurophysics in Leipzig, Germany, Bob has led fMRI and diffusion imaging into very high sub-millimeter spatial resolutions brain imaging using 7 Tesla. I am aware of Bob’s accomplishments in high field imaging, as I have been working in parallel with the CMRR group at University of Minnesota at 7T. I recall the awe in the audience at a highly attended 2011 meeting of the biannual High Field MRI Workshop in Minnesota, when Bob first presented 0.65 mm isotropic resolution in EPI with parallel imaging used for fMRI which was a pivotal and ground breaking result, and made the field realize that such incredibly detailed mapping of the brain was possible to perform routinely at 7T. The subsequent large number of publications coming out of Bob Turner’s lab and collaborative research with many scientists over the last several years, is a testament to his success in further improving high resolution human brain imaging.

I cannot think of anyone who has contributed so much to the development and application of MRI in neurosciences encompassed by the field of human brain imaging who is more deserving of this career award than Bob Turner.

I am available for any questions you may wish to discuss or if you need more information on anything.

With best regards,

David A. Feinberg, M.D., Ph.D.

Adjunct Professor of Neurosciences U.C. Berkeley

President, Advanced MRI Technology,LLC Sebastopol, CA

196

STANFORD UNIVERSITY SCHOOL OF MEDICINE

DEPARTMENT OF RADIOLOGY

GARY H. GLOVER, PH.D. Professor of Radiology, Neurosciences, Biophysics, and EE &Psychology (by courtesy) Director, Radiological Sciences Laboratory (650) 723-7577 / (650) 736-7925 (FAX) [email protected] (EMAIL) http://rsl.stanford.edu/glover March 11, 2014 Organization for Human Brain Mappimg 5841 Cedar Lake Road, Suite 204 Minneapolis, MN 55416

Dear OHBM Glass Brain Committee:

I am delighted to add my strongest enthusiasm for the nomination of Robert Turner for the Glass Brain Award. I’ve known Bob since the inception of fMRI, and there is no doubt that his contributions to the field have been of enormous consequence for everyone involved in this exciting research. I will not bother to recapitulate all his scholarly and academic contributions, because they are well described in the nominating letter of Drs. Rivera, Schafer and Trampel. I will simply add that I was always impressed that at every conference he attended, he always made many remarks during Q&A periods following talks that were insightful and inspiring, and thereby sparked continuous evolution of several generations of young (and old) investigators. His influence thus greatly transcends the hundreds of written papers, books and other scholarship in ways large and small.

Therefore, it is completely fitting that the Organization recognize Prof. Turner for his lifetime achievements, in this year of his retirement.

Sincerely,

Gary H. Glover, Ph.D.

LUCAS MAGNETIC RESONANCE IMAGING CENTER, STANFORD CA 94305-5488

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199 !"#$"%&'&% % FMRIB Centre John Radcliffe Hospital UNIVERSITY OF OXFORD Headington, Oxford NUFFIELD DEPARTMENT OF CLINICAL NEUROSCIENCES OX3 9DU, ENGLAND

Phone: +44 [0]1865 222727 Fax: +44 [0]1865 222717 Email: [email protected]

12 March 2014 Dear Members of the OHBM Council,

Re: OHBM Lifetime Achievement Award

I would like to enthusiastically endorse the nomination of Prof. Robert Turner for an OHBM Lifetime Achievement Award.

Bob has recently retired from the Max Planck Institute for Human Cognitive and Brain Sciences, where he directed the Neurophysics Group for the past 7 years. Prior to this Bob directed the Physics Group of the Wellcome Trust Functional Imaging Laboratory in London. His contributions to functional MRI are wide ranging and highly significant. Recognizing Bob with an OHBM Lifetime Achievement Award would be a truly fitting accolade from a scientific society that he has such an affiliation with and affection for.

As context, I am currently President of the International Society for Magnetic Resonance in Medicine, and am a past-Chair of ISMRM’s Current Issues in Brain Function Study Group. I am also a former postdoc of Bob, and was fortunate to work under him during the earliest days of functional MRI. As you will know, Bob was a co-author on the original 1992 Kwong et al. functional MRI paper, since his prior work on brain hypoxia in cats had contributed to establishing the BOLD contrast mechanism and helped inspire Ken Kwong to apply the method to human functional studies.

However, I have also seen Bob’s lab notes from the mid 1980s in Nottingham in which he was clearly trying to use MRI to study brain function. Had he had access at that time to a higher field strength (he was working at 0.5 Tesla) it is quite possible that BOLD fMRI would have commenced a full half-decade before it did. But a passion for using MRI to study brain function never left Bob, and so when he knew that the MGH group had the EPI hardware and appropriate field strength (1.5 Tesla in those days) to attempt fMRI he joined their effort.

Since then Bob has devoted all his energies to exploring the human brain with functional MRI, with contributions to the biophysical basis and signal characteristics of fMRI, the cognitive neuroscience applications of fMRI, and more recently to the optimization and application of fMRI and structural MRI at ultra-high magnetic field. He has also been a passionate supporter of OHBM and to my knowledge has attended every HBM meeting since their inception. Of course, he has also been an active (enthusiastically so!) in livening many discussions at HBM meetings and other such meetings.

In short, Bob has contributed broadly and substantially to the field of brain mapping, is a true pioneer, and is fully deserving of recognition of the 25+ years he has worked in this field.

Yours sincerely,

Peter Jezzard, PhD Professor of Neuroimaging

Peter Jezzard, PhD, CPhys, FInstP, Herbert Dunhill Professor of Neuroimaging 200 !

!"#$%&'#()*+,*-#(('./&01! !

School of Medicine Department of Radiology 3025 E. Carson St Pittsburgh, PA 15203 412-383-8011 Fax: 412-393-6799

March 11, 2014

RE: 2014 GLASS BRAIN AWARD Nomination of Dr. Robert Turner

Dear Award Selection Committee Members:

I am an endowed Paul C. Lauterbur Chair Professor at the University of Pittsburgh, and the Director of the Center for Neuroscience Imaging Research at the Institute for Basic Science in Korea. My research focus is to determine the relationship between neural activity and fMRI, and to develop novel imaging technologies. I have known Bob Turner from the early days of fMRI; thus, I know %RE¶V research activities very well and can comment on his accomplishments.

Bob¶V VFLHQWLILF DFKLHYHPHQWV DUH WUHPHQGRXV DQG QXPHURXV DV LQGLFDWHG E\ WKH number of citations on his co-authored papers. I will lay out a few of his many seminal and original contributions to fMRI research, which is relevant to human brain mapping.

1) Bob reported the first dynamic BOLD effect in cat brain during gas challenge in 7KLVZRUNZLWK6HLML2JDZD¶s observation in rat brain is the basis of BOLD fMRI contrast. This finding is tremendously important.

2) Bob is co-author of the first human fMRI papers reported at PNAS in 1992 (Kwong et al., PNAS, 1992). These early reports expanded human brain mapping field greatly and created OHBM. Even though human brain mapping is feasible with PET, BOLD fMRI is the major tool to map human brain function.

3) Bob implemented BOLD fMRI at NIH and compared the BOLD contrast between 1.5 T and 4 T in 1993, demonstrating that the high field indeed improves the BOLD sensitivity. This work is among one of the justifications for acquiring high field scanners. Currently, 3-T scanners are commonly available for human brain mapping studies.

201 4) Bob collaborated with many neuroscientists at NIH and in the UK. He co- authored numerous critical fMRI papers, expanding fMRI research to basic and cognitive neuroscience.

Dr. Bob Turner is spearheading human brain mapping, and is one of the most important contributors to the creation and expansion of OHBM. The OHBM owes him greatly for his contribution.

I enthusiastically support Bob Turner for the Glass Brain Award. If you have any questions, please feel free to contact me.

Sincerely,

Seong-Gi Kim, Ph.D. Paul C. Lauterbur Chair in Imaging Research Professor of Radiology, Neurobiology and Bioengineering

202 MASSACHUSETTS HARVARD GENERAL HOSPITAL MEDICAL SCHOOL

Athinoula A. Martinos Center for Biomedical Imaging NMR Research Laboratories Department of Radiology MGH Imaging Center Building 149, Thirteenth Street MR Education Mail Code 149 (2301) Charlestown, Massachusetts 02129-2060 Tel: 617.724.9519, Fax: 617.726.7422 March 13, 2014

To: OHBM Council

I am delighted to support the nomination of Dr. Bob Turner for the Grass Brain Award of OHBM. Bob has made tremendous contribution to neuroscience imaging, especially in MRI in the field of echo planar imaging, diffusion imaging and functional MRI.

Bob’s work on the BOLD responses of cats at the termination of hypoxic challenge provided the first and definitive explanation to why BOLD signal should go up with the increase of perfusion. He made pioneering contributions to early human fMRI studies and continued to help nourish it in its development.

I have known Bob since 1991 whose work had a significant impact on my research. His recognition by OHMB for his extensive and lifelong contribution is most timely. I have no hesitation in providing the highest possible recommendation for Bob, our highly esteemed friend and scientist.

Sincerely,

Kenneth K. Kwong , Ph.D. Associate Professor, Harvard Medical School Martinos Center, Department of Radiology, Massachusetts General Hospital [email protected]

203 !"#$%&"'()$*'+,-,.,/012/3-4&45-+(67/89372'7,-)/ Max Planck Institute for Biological Cybernetics

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Spemannstr. 38 Tel.: +49-(0) 7071 / 601 - 650 [email protected] 205 D-72076 Tübingen Fax: +49-(0) 7071 / 601 - 652 www.kyb.tuebingen.mpg.de !"#$%&"'()$*'+,-,.,/012/3-4&45-+(67/89372'7,-)/ Max Planck Institute for Biological Cybernetics

MPI für biologische Kybernetik Spemannstr. 38 D-72076 Tübingen !

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Spemannstr. 38 Tel.: +49-(0) 7071 / 601 - 650 [email protected] 206 D-72076 Tübingen Fax: +49-(0) 7071 / 601 - 652 www.kyb.tuebingen.mpg.de 207 MPI for Human Cognitive and Brain Sciences PO BOX 50 03 55 04303 Leipzig, Germany · ·

Organization for Human Brain Mapping 5841 Cedar Lake Road, Suite 204 Minneapolis, MN 55416 USA

Leipzig, 10 March 2014

Nomination of Bob Turner for the Glass Brain Award

Dear Members of the Organization for Human Brain Mapping Council:

It is a pleasure to nominate Prof. Bob Turner for the 2014 Glass Brain Award. I have had the opportunity to work with Prof. Turner while he was director of the Department of Neurophysics at the Max Planck Institute for Human Cognitive and Brain Sciences. While I have no doubt that many others who were present in the early days of human neuroimaging can better describe his numerous foundational contributions to the field, his most recent trailblazing lines of research using 7 Tesla MRI continue to push the field forward. As we advance the limits of high resolution brain mapping, Prof. Turner has spear- headed novel directions into the description of myeloarchitectonics, resurrecting this long forgotten research agenda into cortical parcellation. Prof. Turner has been a generous mentor, a steadfast advo- cate of methodological innovations, and a vocal participant in innumerable conferences. He has published across all fields of human neuroimaging, ranging in topics from physics to the anthropology. His thoughtful discussions with colleagues and students, and his widespread impact on the challenges and controversies within our field, accentuate the personal impact he has had on our community. Consid- ering his continued involvement with OHBM as a member of the Local Organizing Committee of the 20th Meeting of the Organization for Human Brain Mapping, I believe he would be an ideal recipient of the Glass Brain Award for lifetime achievement in the field of human brain mapping.

Yours sincerely,

Daniel Margulies, Ph.D.

Dr Daniel S. Margulies Stephanstrasse 1A Tel. +49 (0) 341 9940-2612 [email protected] Group Leader 04103 Leipzig, Germany Fax +49 (0) 341 9940-2221 www.cbs.mpg.de/~margulies

208 !

13th March, 2014

Organization for Human Brain Mapping 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 USA

Dear Colleagues, It is with great pleasure that I write to support the OHBM Glass Brain Award nomination for Dr. Robert Turner by the Max Planck Institute for Human Cognitive and Brain Sciences. I have known Bob Turner for almost a quarter of a century, and he would be an outstanding, if unconventional choice for this lifetime achievement award. The world of brain mapping would have been very different if it were not for his foundational contributions and continuing achievements.

I use the term “unconventional” because Bob’s contributions to human brain imaging predate the OHBM and the term “brain mapping”, and without the advances he contributed, it’s entirely possible that the brain mapping field may not have evolved the way it did. To understand this, one needs to understand that two of the major tools used for human brain mapping (DTI and fMRI) rely on two significant technical developments that Bob Turner played a fundamental role in. The first of these was shielded gradient coils. Turner’s target field approach for gradient coil design was a critical development for modern MRI, allowing fast slewing gradients with minimal eddy currents. Without this technology, techniques such as EPI were simply not practical. I remember reading his beautifully written descriptions of tuning EPI acquisitions in the GE CSI Omega newsletters. It is how I learned to do EPI.

Following the gradient coil developments, Bob continued to devlop pulse sequences that could exploit these improved gradient coils. Two direct applications were diffusion weighted imaging and fMRI. In both cases echo-planar imaging was the key imaging technique that made these applications practical and Bob was a leader in its implementation. In the case of fMRI this was clear from his time- series studies of cat brain oxygenation that EPI rather than FLASH was the way to go for the rapid * acquisition of serial T2 MRI volumes. For diffusion weighted and IVIM, his work with Denis LeBihan was pioneering as well. This set the stage for the evolution of DTI. Variants of all of these approaches that he pioneered are still in use today.

Starting in the early 90’s at NIH, he then turned to exploiting these tools for the study of human brain function, collaborating with leading neuroscientists such as Leslie Ungerleider and Judith Rapoport. Because of his diverse educational background, he brought a very different perspective on human brain function than classically trained neuroscientists. Countless fMRI studies have benefitted from this perspective. He also did some important characterization of the BOLD signal that is exploited in fMRI, include field strength dependent studies that showed some early benefits to higher field strengths. He built further on these studies in his days in London working productively with many other leaders in the brain mapping field including Buchel and Friston, as well as some of the original MRI

Centre for Functional and Metabolic Mapping, Western University Robarts Research Institute, 1151 Richmond Street North, London, ON, Canada N6A 5K7 t. 519.931.5777 x24148 [email protected] cfmm.robarts.ca! 209 founders like Ordidge. This last interaction appears to have reinvigorated his interest in anatomical imaging.

Bob has often concerned himself with the important details of BOLD fMRI that neuroscientists are happy to ignore. Issues such as what the fMRI signal means, what the effect of draining veins are, where the artifacts come from and what can be done about all this. These questions become very important as one pushes the resolution in functional imaging and he has made important contributions to their understanding. Some of his more recent elegant work in Leipzig focuses on the acquisition and interpretation of extremely high-resolution anatomical imaging and the pulse sequences and motion correction methodologies to allow the visualization and interpretation of tissue microstructure containing iron and/or myelin. Frankly, I think this is some of his most elegant work, and the images he has published are the best in the world.

Bob has an encyclopedic knowledge of MRI, neuroscience and human brain mapping. He can be found at the microphone of any meeting he is attending, with a thought-provoking question in hand. It’s simply impossible to summarize a 30 year career in imaging (as part of a 50 year career in physics) in a few short paragraphs. What can be said is that the landscape of human brain mapping would be very different if Bob Turner had not turned his considerable talents to this field. I don’t think that can be said of many people in our field. As such, I think Dr. Turner would be a terrific a and deserving recipient of the Glass Brain Award. He and his research have touched several generations of us who work in the area that has come to be called “brain mapping”.

Sincerely,

Ravi S. Menon, Ph.D. Canada Research Chair in Functional Magnetic Resonance Imaging, Director, Centre for Functional and Metabolic Mapping, Professor of Medical Biophysics, Medical Imaging & Psychiatry, Schulich School of Medicine and Dentistry Professor of Physics Member, Graduate Programs in Neurosciences and Biomedical Engineering Western University

Robarts Research Institute, 1151 Richmond Street North, London, ON, Canada N6A 5K7 t. 519.931.5777 x24148 [email protected] cfmm.robarts.ca!

! 210

UCL INSTITUTE OF COGNITIVE NEUROSCIENCE DIRECTOR: PROF. GERAINT REES FMedSci

Professor Steve Smith, Chair, OHBM Council 5841 Cedar Lake Road, Suite 204 Minneapolis, MN 54416

12th March 2014

Dear Steve,

I am delighted to offer my strongest support for the nomination of Professor Robert Turner for the OHBM 2014 Glass Brain award. I have known Bob since 1995 when I joined the Wellcome Department of Cognitive Neurology as a clinical fellow, and his work has been critical both to the success of my own research group and the broader field of human neuroimaging.

Bob has made major contributions to neuroimaging in three key areas. First, his work in the 1980s and 1990s in Nottingham and at NIH on gradient coils and echo planar imaging established the target field method and key principles of gradient coil design that underpin all functional MRI used worldwide today.

Second, he conducted a number of key studies in the early 90s that established how echo planar imaging could be used to produce maps of water diffusion in brain tissue (the basis of diffusion weighted imaging); and that it could be used to monitor blood oxygenation in the animal and then human brain (the basis of all functional MRI).

Finally, Bob played a critical role in establishing two global centres for MR research; the Wellcome Department of Cognitive Neurology (now the Wellcome Trust Centre for Neuroimaging) at UCL, and the high field 7T system at the Max- Planck Institute for Cognitive and Brain Sciences in Leipzig. During his time in both centres, he continued to refine and research improvements to the acquisition procedures, significantly enhancing the productivity of scientists working in those centres and helping establish functional MRI as a widely used technique worldwide.

Bob has thus made fundamental technical and conceptual contributions that underpin the scientific development of neuroimaging as an accepted and widespread technique in neuroscience; and has made very significant contributions to the scientific leadership that has established key global centres for neuroimaging research.

Bob is one of the small number of people worldwide who are effective working at the boundary between MR techniques and MR applications, and his achievements have been fundamental in translating advances in MR physics into applicable techniques and approaches that are now used routinely throughout the world by many thousands of scientists. Moreover, these achievements have been delivered in a highly collegiate fashion with a modest, self-deprecating style that belies his profound contribution to the field. I am delighted to offer my strongest and most enthusiastic recommendation.

Yours sincerely,

Professor Geraint Rees FMedSci Director, UCL Institute of Cognitive Neuroscience

UCL Institute of Cognitive Neuroscience 17 Queen Square, London WC1N 3AR Tel: +44 (0)20 7679 5496 Fax: +44 (0)20 7813 2835 http://icn.ucl.ac.uk 211 DATE: March 13, 2014

TO: OHBM Council, Award Committee Organization for Human Brain Mapping, Minneapolis, Minnessota; USA

FROM: Robert G Shulman Sterling Prof (emeritus) of Molecular Biophysics and Biochemistry Yale University New Haven CT; USA

Dear Members of the Award Committee,

I have been an admirer of Bob Turner ever since he traveled the world, in the early 1990ʼs from his bases in Harvard and Nottingham advocating the value of echo planar imaging, to more recently when he was uniquely able to relate physics to the importance of social science in modern brain imaging. The advances in imaging that he has to a substantial degree responsible for (echo–planar imaging, shift reagents used for the first imaging experiment in humans and for imaging and questioning of the philosophical basis of Cognitive Neuroscience), have brought him to face the role of the human sciences in these studies of human behavior. In his efforts to find novel modules of thought for interpreting imaging results he has examined how the present paradigm of mind and brain needs to be examined in light of these results. He has studied imaging science from this highly civilized level of thought which should be a model for our field.

It is my pleasure to recommend him for the OHBM award for a career devoted to discovering and improving brain imaging.

Sincerely, Robert G Shulman Sterling Prof (emeritus) of Molecular Biophysics and Biochemistry Yale University New Haven CT USA

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213 HARVARD MEDICAL SCHOOL MASSACHUSETTS GENERAL HOSPITAL

Lawrence L. Wald, Ph.D. Associate Professor, Dept. of Radiology MGH Martinos Center for Biomedical Imaging th Building 149, 13 Street, Rm 2301, Charlestown, Massachusetts 02129 Phone: (617) 724-9706 Fax: (617) 726-7422 [email protected]

OHBM Council March. 13, 2014 Organization for Human Brian Mapping 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 USA

Re: Nomination of Prof. Robert Turner for OHBM Glass Brain Award.

Dear Sir or Madam,

I am pleased to write in support of Dr. Robert Turner's nomination for the OHBM “Glass Brain Award, a lifetime achievement award in the field of human brain mapping.” I think there can be very little doubt that few individuals could be more deserving of this award than Prof. Turner. He has a 20 year record of contributing at a fundamental level to all aspects of this field that can only be called “relentless”. He was involved in the first human subject BOLD experiments (in fact, he was the first human subject), and his early cat experiments were responsible for changing the thinking of many in the field. Ogawa’s paper, pioneering though it was, viewed the BOLD effect as a vascular effect, since that is all he saw in his images. But Turner’s cat images showed that the BOLD effect was a parenchyma effect, not just some large vein thing. I know that this had a major influence on the thinking of early fMRI researchers at my institution, as it gave the BOLD effect credibility as a fundamental signature rather than a down-stream effect. The impressive thing about Bob’s work is that it was (is) relentless. He has been involved in all aspects of the fMRI experiment. Although known as a neuroscientist/imager rather than a “hardware” guy, he contributed a good bit to making fMRI possible thru improved hardware and pulse sequences. He developed the target field method currently used to design gradient coils, and worked on the first shielded gradient coils (critical to fMRI today), to building the head gradients needed for the first fMRI experiments to his current work modeling ultra-high field RF coils. He was also an early developer of EPI, which is of course central in the fMRI development story and was a technical hurdle that needed to be overcome before fMRI could become a widespread neuroscience method. He is central in the development of our ideas about the physiology of the effects we see, and he has contributed multiple processing methods.

214 Although he is now officially retired, he continues to make important progress to the field, such as looking for cortical signatures of Brodmann areas in the myelin architecture maps visible at ultra-high field and pushing the spatial resolution of fMRI into the laminar regime. In short, there is a reason that “everyone knows Bob” and its not just because he is the one at the microphone with a question after your talk that spilled out into a discussion in the hallway afterward. He has contributed fundamental breakthroughs as well as the day-to-day intellectual glue that holds a field like ours together and helps all advance. I feel that he deeply deserves this award. Please do not hesitate to contact me if you have any questions regarding these issues.

Sincerely,

Lawrence L. Wald, Ph.D.

215 ! ! ! ! ! !!!!!! !! ! !

March 14, 2014

OHBM Council

Dear Sirs,

I would like to share with you my unreserved and most enthusiastic support for the nomination of Robert Turner for OHBM’s Lifetime Achievement “Glass Brain” Award.

216 As one recent example, in the spring of 2013, I attended with Bob an NSF-sponsored workshop in Alexandria VA in response to President Obama’s new Brain initiative. While many attendees advocated narrow agendas, Bob was eloquent for the need and opportunity to go beyond the frontiers of present approaches – for example, to continue the quest to map, for example electrical current sources, or the potential to map structure and connectivity with multiple mechanisms for new subtly and insight. I mention this because it demonstrates how Bob has been so effective as a leader – at once inclusive, visionary and concrete, and also to create the foundation for his deepest commitment, which I would say, and believe he would agree, has always been to teaching and the next generation.

Yours respectfully,

217 DBBS Faculty Member David Van Essen, Ph.D. Professor Anatomy and Neurobiology

Email Website Contact Info More Publications Primate cerebral cortex: structure, function, connectivity, development, and evolution The Van Essen lab uses neuroimaging approaches combined with novel methods of computerized brain mapping and neuroinformatics to explore the functional organization, connectivity, development, and evolution of cerebral cortex in humans and nonhuman primates. The Human Connectome Project (HCP; http://www.humanconnectome.org/) involves a large-scale collaborative effort to chart long-distance connectivity and its variability in healthy adult humans. Our contribution to the HCP includes the development and application of analysis methods for characterizing brain connectivity, and the development of a user-friendly platform for data mining of the HCP datasets that will be made freely available to the neuroscience community.

Our studies of cortical development involve a collaborative effort with pediatric neurologists (Drs. Terrie Inder and Jeff Neil) to characterize normal and abnormal patterns of cortical folding in preterm infants. We also have characterized abnormalities in cortical folding in a variety of brain disorders, including Williams Syndrome, autism, schizophrenia, and ADHD.

Our interests in evolution focus on comparisons of cortical organization in monkeys, apes, and humans, using surface-based atlases and interspecies surface-based registration. This approach enables objective evaluation of candidate homologies across species and quantitative assessments of cortical expansion during human evolution.

The explosion of information in the neurosciences demands fresh approaches to data sharing and data mining. To this end, we have established the SumsDB database (http://sumsdb.wustl.edu/sums/) as a repository for many types of neuroimaging data. This includes a large and freely accessible library of stereotaxic coordinates, representing summary results from thousands of fMRI, PET, and structural imaging studies.

218 219 220 221 Curriculum vitae Prof. Dr. med. Dr. med. h.c. Karl Zilles (MD, PhD)

Personal Data

Date/Place of Birth: 01.04.1944 in Würzburg (Germany) Address: Institute of Neuroscience and Medicine (INM-1) Research Centre Jülich 52425 Jülich (Germany) Phone: +49-2461-613015 Email: [email protected]

Citizenship: German

Scientific career since 2012 Senior Professor of the Jülich-Aachen Research Alliance (JARA), Research Centre Jülich (Germany) & RWTH University of Aachen (Germany) 1998 – 2012 Director of the Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich (Germany) 1991 – 2012 Full Professor and Director of the C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf (Germany) 1991 – 2002 Full Professor and Director of the Department of Neuroanatomy, Heinrich-Heine- University Düsseldorf (Germany) 1981 – 1991 Full Professor and Director of the Institute of Anatomy, University of Cologne (Germany) 1979 – 1981 Associate Professor, Institute of Anatomy, University of Kiel (Germany) 1977 – 1979 Prosector, Institute of Anatomy, University of Kiel (Germany) 1977 Habilitation in Anatomy, Medical School Hannover (Germany) 1971 – 1977 Research Assistant and Research Fellow, Institute of Anatomy, Department of Neuroanatomy, Medical School Hannover (Germany) 1971 Medical license granted 1970 Medical state examination

Awards, Honors and Memberships (Selection) Awards and Honors 2012 Guest Professor, University of Stanford, Palo Alto (USA) 2011 Honorary Doctorate Degree (Dr. med. h.c.), University of Rostock (Germany) since 2010 Fellow of the Academy of Science and Arts of North Rhine-Westphalia (Germany) 2006 Research award of the Dr. Robert Pfleger foundation

222 2003 – 2006 Member of the Council and Meetings Liaison of the Organization for Human Brain Mapping (OHBM) 2003 – 2014 Spokesperson of the research program “Function and Dysfunction of the Nervous System” of the Helmholtz Association (Germany) since 2002 Member of the Scientific Advisory Board of the Institute for Science and Ethics, Bonn (Germany) since 1998 Fellow of the German National Academy of Sciences – Leopoldina 1999 – 2000 President of the European Federation of Experimental Morphology 1998 – 2002 Spokesperson of the Collaborative Research Centre (SFB 194) “Function and Dysfunction in the Nervous System” of the German Research Council (DFG) 1996 Vice-President of the Anatomical Society of Great Britain and Ireland 1995 – 1996 President of the German Anatomical Society 1994 – 1998 Member of the Council of the German Anatomical Society 1992 – 1997 Secretary General of the European Federation of Experimental Morphology 1965 – 1970 Scholarship of the German National Academic Foundation

Membership in scientific organizations since 1995 Organization for Human Brain Mapping (OHBM) since 1994 Anatomical Society of Great Britain and Ireland since 1992 German Neuroscience Society (Neurowissenschaftliche Gesellschaft) since 1987 Society for Neuroscience (SfN; USA) since 1981 European Neuroscience Association (ENA) since 1972 German Anatomical Society (Anatomische Gesellschaft)

Editorial Work since 2007 Founding Editor and Editor-in-Chief „Brain Structure and Function“ – the impact factor of the journal grew up from 0 (2007) to 7.83 (2013) Previously Editor-in-Chief „Anatomy and Embryology“ and Section Editor „NeuroImage“

Co-Editor of Journals and Monography Series Advances in Anatomy, Embryology and Cell Biology; Journal of Brain Research; Annals of Anatomy; Journal of Chemical Neuroanatomy (until 2008); NeuroBiology; Neurology, Psychiatry & Brain Research; Journal of Neuroscience Methods Co-Editor of Textbooks • Textbook „Anatomie“ (Anatomy), Springer (published 2010); Co-Editors: Zilles, Tillmann • Textbook „Funktionelle Neuroanatomie” (Functional Neuroanatomy), Springer (published 1993 (1st edition), 1994 (2nd edition), 1998 (3rd edition); Co-Editors: Zilles, Rehkämper • Textbook „Rauber/Kopsch: Anatomie des Menschen“ (Human Anatomy), Thieme (4 volumes); Co-Editors: Leonhardt, Tillmann, Zilles • Textbook „Anatomie“ (Anatomy), Springer; Co-Editors: Schiebler, Schmidt, Zilles

223 Benchmarking

• Top 100 most frequently cited scientists worldwide in „Neuroscience & Behavior“ (1997 – 2007) Rank 41 (5,741 citations) out of 3,170 scientists, top-ranked German scientist 1.3% most frequently cited scientists worldwide Essential Science Indicators (http://www.in-cites.com/nobel2007-neu-top100.html) • Rank 1 most frequently cited scientists in German-speaking countries in „Anatomy“ (1999 – 2001; 2000 – 2002; 2002 – 2005)

Publication record

• original articles 586 first author 67 senior author 206 • books / book chapters 94 • citations (total) 28,797 • h-index 84

Education and Teaching (Selection)

• 75 supervised doctoral theses (PhD and MD) 6 research / ‘best thesis’ awards (three times in a row 2007 – 2009) • 9 supervised habilitation theses • 17 former doctoral students and PostDocs promoted to associate and full professorships

• Co-organizer of the educational course: “Anatomy and its impact on structural and functional imaging” at the Annual Meetings of the Organization for Human Brain Mapping since 2011 • Participation at the Annual Neuroradiology and Functional Neuroanatomy Course, London (since 2008)

224

• PhD training courses on neuroanatomy, Research Centre Jülich (Germany) • Lectures, micro- and macroanatomical practical courses, and seminars in “Anatomy” and “Neuroanatomy” in each semester as assistant, associate and full professor at the universities of Hannover, Kiel, Cologne, and Düsseldorf, respectively (since 1971)

225

McConnell Brain Imaging Center Alan C Evans, Ph.D Montreal Neurological Institute Tel. (514) 398 8926 3801 University Street Fax (514) 398 8948 Email: [email protected] Montreal, QC Canada H3A2B4

Montreal March 11th, 2014

Nomination of Karl Zilles for the inaugural OHBM Glass Brain Award

Dear OHBM Council, It is a great pleasure for me to write in support of the proposal to award the inaugural OHBM Glass Brain Award to Professor Karl Zilles. I have known Karl personally for 21 years and followed his prodigious body of work for 25 years. We are long-time collaborators within the International Consortium for Brain Mapping. Most recently, we worked together on the creation of the BigBrain dataset, a high resolution 3D image of the human brain (20µ isotropic resolution). This dataset had a major international impact in 2013, with many applications as a template for neuroimage analysis and modelling, teaching, neurosurgical training and cytoarchitectural mapping.

Zilles is the leading figure in the world at the interface between classical neuroanatomy and modern brain imaging research techniques. His credentials as a neuroanatomist are peerless, as a Director of the Vogt Institute. However, there are many other outstanding neuroanatomists in the world. What really distinguishes Karl Zilles is his integration of the traditional skills of a master neuroanatomist with a tremendous range of human imaging tools (MRI, fMRI, PET, MEG) to revolutionize our understanding of functional neuroanatomy. The fundamental works of Von Economo, Brodmann, Flechsig and Sarkissov were based on distinguishing cortical areas on the basis of a few cellular characteristics visible under the microscope. Zilles has pioneered an approach, known as chemoarchitectural fingerprinting, that incorporates far more information about neuroreceptor density at every 3D location (voxel) in the brain. Potentially dozens of different neurochemical attributes can be assigned to each voxel, such that spatial patterns of correlated receptor distributions can be extracted. Subtle organizational features can be revealed that go far beyond the simplistic notion of cytoarchitectural zones that have discrete, immutable boundaries. Ultimately, this process has the voxel as its core element not the region. In the past, we did not have the computational resources to manipulate such vast amounts of data. This is no longer the limiting factor and Zilles has established a powerful multi-disciplinary laboratory in Jülich to (i) handle the immense image processing challenges, and (ii) ensure that computational virtuosity does not lose sight of its historical neurobiological legacy as the re-vivified of functional neuroanatomy emerges. We are in the midst of complete restructuring of functional neuroanatomy and Zilles is at the absolute forefront of this revolution. His vision and

226 drive has built the Jülich laboratory into one of the great capitals of human brain mapping.

Recently, Zilles has pioneered another approach to high-resolution neuroanatomy, polarized light imaging (PLI), that reveals stunning images of white matter pathways at 1-2µ. This will complement the cytoarchitectural mapping of the BigBrain dataset and inform our quantitative interpretation of in vivo tractography maps obtained via diffusion imaging. We are still at the beginning of this new technique but PLI promises to re-define the white matter connectivity of the human brain in the coming decade.

Owing to his classical training, he has been able to bridge the gap between computational imaging, basic wet laboratory techniques and the traditional neuroanatomy. He is painstakingly working through the chemoarchitectural mapping of Brodmann areas, making the results available to the community in the form of 3D digital atlases of the spatial distribution and inter-subject variability of these receptor distributions. I have had many opportunities to watch Karl Zilles in action and he never fails to impress the audience with his meticulous attention to technical detail, encyclopaedic knowledge of neuraonatomy/neuropathology and grand vision. He has held many important positions within the field of brain imaging, particularly within OHBM, and is a regular participant in multi-national collaborations.

Beyond his own scientific credentials, he has trained many younger scientists who are now leading figures in the brain mapping field, including Katrin Amunts, Simon Eickhoff and Gereon Fink. He is a superb mentor, both demanding and nurturing, with an infinite supply of anecdotes that capture the historical arc of neuroanatomy as well as its modern rebirth. I have sat in awe on many occasions as Karl launches into stories that place our field in the context of developmental neurobiology, neurodegenerative diseases and cognitive neuroscience.

In summary, Karl Zilles is an iconic figure in the field of brain mapping and someone who in due course will be ranked alongside the giants in the field of neuroanatomy. There is no question in my mind that he merits the OHBM Glass Brain Award for his many years of leadership at the interface between classical neuroanatomy and modern multimodal brain mapping.

Yours sincerely,

Alan C Evans., Ph.D., James McGill Professor of Neurology, Psychiatry and Biomedical Engineering, McGill University/Montreal Neurological Institute,

227 University Of Oxford Nuffield Department of Clinical Neurosciences

Prof. Heidi Johansen-Berg Wellcome Trust Senior Research Fellow Professor of Cognitive Neuroscience

FMRIB Centre Phone: +44 (0) 1865 222548 John Radcliffe Hospital Fax: +44 (0) 1865 222717 Headington Email: [email protected] Oxford OX3 9DU www.fmrib.ox.ac.uk/~heidi

9th$March$2014$ $ I$would$like$to$provide$my$strongest$support$for$Prof$Karl$Zilles$nomination$for$the$OHBM$Glass$Brain$ Award.$Prof$Zilles$has$demonstrated$truly$outstanding$contributions$to$the$field$of$human$brain$mapping$ and$I$believe$him$to$be$a$highly$deserving$recipient$of$the$Glass$Brain$Award.$$ $ Prof$Zilles’$research$contribution$to$the$field$is$unique$and$has$had$enormous$impact.$The$work$of$his$group$ has$transformed$the$field$of$human$cortical$mapping.$It$is$also$commendable$that$he$has$worked$ enthusiastically$to$share$this$outstanding$work$with$the$community$through$atlases$etc.$$Prof$Zilles$work$is$ grounded$in$classical$neuroanatomy$but$he$embraced$the$opportunities$offered$by$developments$in$ neuroimaging.$His$engagement$with$neuroimaging$technology,$and$with$the$neuroimaging$community,$has$ meant$that$the$anatomical$work$of$his$group$has$had$very$broad$impact.$By$bringing$a$different$perspective$ from$those$of$us$‘raised’$in$the$neuroimaging$world,$he$has$provided$inspiration$to$many$neuroimagers$to$ recognise$that$brain$anatomy$has$huge$relevance$to$the$study$of$brain$function.$$ $ Prof$Zilles$has$been$an$active$and$involved$member$of$OHBM$for$many$years.$He$has$regularly$contributed$ to$educational$sessions$and$symposia.$His$keynote$in$2012$was$outstanding$–$prompting$a$spontaneous$ standing$ovation$from$the$audience.$$When$I$first$organised$an$anatomy$course$for$the$educational$ sessions$in$2009$I$was$delighted$when$Prof$Zilles$agreed$to$speak.$I$was$then$extremely$impressed$that$he$ attended$the$full$course$and$contributed$enthusiastically$to$discussions.$This$experience$was$repeated$for$ many$years.$I$know$that$attendees$were$hugely$appreciative$that$Prof$Zilles$was$so$engaged$with$the$ sessions.$$I$also$recall$the$first$time$I$met$Prof$Zilles,$when$I$was$attending$OHBM$as$an$early$postdoc$and$ presenting$anatomical$work$using$diffusion$imaging.$He$visited$my$poster$and$spending$an$enthusiastic$20$ minutes$or$so$discussing$it$with$me.$I$have$been$consistently$impressed$since$then$with$his$enthusiasm$for$ engaging$fully$with$the$community,$from$visiting$students’$posters$to$voicing$his$opinion$in$a$packed$lecture$ hall.$$ $ I$can$think$of$no$more$deserving$recipient$for$the$first$OHBM$Glass$Brain$Award.$$ $ Yours,$ $ $ $ $ $ $ Prof$Heidi$JohansenRBerg$

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