Winners of the Brain Prize 2017
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Biomedical Sciences 2 DRAFT 9/13/16
1 1 Report of the SEAB Task Force on Biomedical Sciences 2 DRAFT 9/13/16 3 Executive Summary 4 Progress in the biomedical sciences has crucial implications for the Nation’s health, security, 5 and competitiveness. Advances in biomedicine depend increasingly upon integrating many other 6 disciplines---most importantly, the physical and data sciences and engineering---with the 7 biological sciences. Unfortunately, the scientific responsibilities of the various federal agencies 8 are imperfectly aligned with that multidisciplinary need. Novel biomedical technologies could be 9 developed far more efficiently and strategically by enhanced inter-agency cooperation. The 10 Department of Energy’s mission-driven basic research capabilities make it an especially promising 11 partner for increased collaboration with NIH, the nation’s lead agency for biomedical research; 12 conversely, the NIH is well-positioned to expand its relationships with DOE. Particular DOE 13 capabilities of interest include instrumentation, materials, modeling and simulation, and data 14 science, which will find application in many areas of biomedical research, including cancer, 15 neurosciences, microbiology, and cell biology; the analysis of massive heterogeneous clinical and 16 genetic data; radiology and radiobiology; and biodefense. 17 To capitalize on these opportunities we recommend that the two agencies work together 18 more closely and in more strategic ways to A) define joint research programs in the most fertile 19 areas of biomedical research and applicable technologies; B) create organizational and funding 20 mechanisms that bring diverse researchers together and cross-train young people; C) secure 21 funding for one or more joint research units and/or user facilities; D) better inform OMB, 22 Congress, and the public about the importance of, and potential for, enhanced DOE-NIH 23 collaboration. -
Machine Learning for Neuroscience Geoffrey E Hinton
Hinton Neural Systems & Circuits 2011, 1:12 http://www.neuralsystemsandcircuits.com/content/1/1/12 QUESTIONS&ANSWERS Open Access Machine learning for neuroscience Geoffrey E Hinton What is machine learning? Could you provide a brief description of the Machine learning is a type of statistics that places parti- methods of machine learning? cular emphasis on the use of advanced computational Machine learning can be divided into three parts: 1) in algorithms. As computers become more powerful, and supervised learning, the aim is to predict a class label or modern experimental methods in areas such as imaging a real value from an input (classifying objects in images generate vast bodies of data, machine learning is becom- or predicting the future value of a stock are examples of ing ever more important for extracting reliable and this type of learning); 2) in unsupervised learning, the meaningful relationships and for making accurate pre- aim is to discover good features for representing the dictions. Key strands of modern machine learning grew input data; and 3) in reinforcement learning, the aim is out of attempts to understand how large numbers of to discover what action should be performed next in interconnected, more or less neuron-like elements could order to maximize the eventual payoff. learn to achieve behaviourally meaningful computations and to extract useful features from images or sound What does machine learning have to do with waves. neuroscience? By the 1990s, key approaches had converged on an Machine learning has two very different relationships to elegant framework called ‘graphical models’, explained neuroscience. As with any other science, modern in Koller and Friedman, in which the nodes of a graph machine-learning methods can be very helpful in analys- represent variables such as edges and corners in an ing the data. -
Genetic Algorithms Are a Competitive Alternative for Training Deep Neural Networks for Reinforcement Learning
Deep Neuroevolution: Genetic Algorithms are a Competitive Alternative for Training Deep Neural Networks for Reinforcement Learning Felipe Petroski Such Vashisht Madhavan Edoardo Conti Joel Lehman Kenneth O. Stanley Jeff Clune Uber AI Labs ffelipe.such, [email protected] Abstract 1. Introduction Deep artificial neural networks (DNNs) are typ- A recent trend in machine learning and AI research is that ically trained via gradient-based learning al- old algorithms work remarkably well when combined with gorithms, namely backpropagation. Evolution sufficient computing resources and data. That has been strategies (ES) can rival backprop-based algo- the story for (1) backpropagation applied to deep neu- rithms such as Q-learning and policy gradients ral networks in supervised learning tasks such as com- on challenging deep reinforcement learning (RL) puter vision (Krizhevsky et al., 2012) and voice recog- problems. However, ES can be considered a nition (Seide et al., 2011), (2) backpropagation for deep gradient-based algorithm because it performs neural networks combined with traditional reinforcement stochastic gradient descent via an operation sim- learning algorithms, such as Q-learning (Watkins & Dayan, ilar to a finite-difference approximation of the 1992; Mnih et al., 2015) or policy gradient (PG) methods gradient. That raises the question of whether (Sehnke et al., 2010; Mnih et al., 2016), and (3) evolution non-gradient-based evolutionary algorithms can strategies (ES) applied to reinforcement learning bench- work at DNN scales. Here we demonstrate they marks (Salimans et al., 2017). One common theme is can: we evolve the weights of a DNN with a sim- that all of these methods are gradient-based, including ES, ple, gradient-free, population-based genetic al- which involves a gradient approximation similar to finite gorithm (GA) and it performs well on hard deep differences (Williams, 1992; Wierstra et al., 2008; Sali- RL problems, including Atari and humanoid lo- mans et al., 2017). -
Acetylcholine in Cortical Inference
Neural Networks 15 (2002) 719–730 www.elsevier.com/locate/neunet 2002 Special issue Acetylcholine in cortical inference Angela J. Yu*, Peter Dayan Gatsby Computational Neuroscience Unit, University College London, 17 Queen Square, London WC1N 3AR, UK Received 5 October 2001; accepted 2 April 2002 Abstract Acetylcholine (ACh) plays an important role in a wide variety of cognitive tasks, such as perception, selective attention, associative learning, and memory. Extensive experimental and theoretical work in tasks involving learning and memory has suggested that ACh reports on unfamiliarity and controls plasticity and effective network connectivity. Based on these computational and implementational insights, we develop a theory of cholinergic modulation in perceptual inference. We propose that ACh levels reflect the uncertainty associated with top- down information, and have the effect of modulating the interaction between top-down and bottom-up processing in determining the appropriate neural representations for inputs. We illustrate our proposal by means of an hierarchical hidden Markov model, showing that cholinergic modulation of contextual information leads to appropriate perceptual inference. q 2002 Elsevier Science Ltd. All rights reserved. Keywords: Acetylcholine; Perception; Neuromodulation; Representational inference; Hidden Markov model; Attention 1. Introduction medial septum (MS), diagonal band of Broca (DBB), and nucleus basalis (NBM). Physiological studies on ACh Neuromodulators such as acetylcholine (ACh), sero- indicate that its neuromodulatory effects at the cellular tonine, dopamine, norepinephrine, and histamine play two level are diverse, causing synaptic facilitation and suppres- characteristic roles. One, most studied in vertebrate systems, sion as well as direct hyperpolarization and depolarization, concerns the control of plasticity. The other, most studied in all within the same cortical area (Kimura, Fukuda, & invertebrate systems, concerns the control of network Tsumoto, 1999). -
Model-Free Episodic Control
Model-Free Episodic Control Charles Blundell Benigno Uria Alexander Pritzel Google DeepMind Google DeepMind Google DeepMind [email protected] [email protected] [email protected] Yazhe Li Avraham Ruderman Joel Z Leibo Jack Rae Google DeepMind Google DeepMind Google DeepMind Google DeepMind [email protected] [email protected] [email protected] [email protected] Daan Wierstra Demis Hassabis Google DeepMind Google DeepMind [email protected] [email protected] Abstract State of the art deep reinforcement learning algorithms take many millions of inter- actions to attain human-level performance. Humans, on the other hand, can very quickly exploit highly rewarding nuances of an environment upon first discovery. In the brain, such rapid learning is thought to depend on the hippocampus and its capacity for episodic memory. Here we investigate whether a simple model of hippocampal episodic control can learn to solve difficult sequential decision- making tasks. We demonstrate that it not only attains a highly rewarding strategy significantly faster than state-of-the-art deep reinforcement learning algorithms, but also achieves a higher overall reward on some of the more challenging domains. 1 Introduction Deep reinforcement learning has recently achieved notable successes in a variety of domains [23, 32]. However, it is very data inefficient. For example, in the domain of Atari games [2], deep Reinforcement Learning (RL) systems typically require tens of millions of interactions with the game emulator, amounting to hundreds of hours of game play, to achieve human-level performance. As pointed out by [13], humans learn to play these games much faster. This paper addresses the question of how to emulate such fast learning abilities in a machine—without any domain-specific prior knowledge. -
When Planning to Survive Goes Wrong: Predicting the Future and Replaying the Past in Anxiety and PTSD
Available online at www.sciencedirect.com ScienceDirect When planning to survive goes wrong: predicting the future and replaying the past in anxiety and PTSD 1 3 1,2 Christopher Gagne , Peter Dayan and Sonia J Bishop We increase our probability of survival and wellbeing by lay out this computational problem as a form of approxi- minimizing our exposure to rare, extremely negative events. In mate Bayesian decision theory (BDT) [1] and consider this article, we examine the computations used to predict and how miscalibrated attempts to solve it might contribute to avoid such events and to update our models of the world and anxiety and stress disorders. action policies after their occurrence. We also consider how these computations might go wrong in anxiety disorders and According to BDT, we should combine a probability Post Traumatic Stress Disorder (PTSD). We review evidence distribution over all relevant states of the world with that anxiety is linked to increased simulations of the future estimates of the benefits or costs of outcomes associated occurrence of high cost negative events and to elevated with each state. We must then calculate the course of estimates of the probability of occurrence of such events. We action that delivers the largest long-run expected value. also review psychological theories of PTSD in the light of newer, Individuals can only possibly approximately solve this computational models of updating through replay and problem. To do so, they bring to bear different sources of simulation. We consider whether pathological levels of re- information (e.g. priors, evidence, models of the world) experiencing symptomatology might reflect problems and apply different methods to calculate the expected reconciling the traumatic outcome with overly optimistic priors long-run values of alternate courses of action. -
Pnas11052ackreviewers 5098..5136
Acknowledgment of Reviewers, 2013 The PNAS editors would like to thank all the individuals who dedicated their considerable time and expertise to the journal by serving as reviewers in 2013. Their generous contribution is deeply appreciated. A Harald Ade Takaaki Akaike Heather Allen Ariel Amir Scott Aaronson Karen Adelman Katerina Akassoglou Icarus Allen Ido Amit Stuart Aaronson Zach Adelman Arne Akbar John Allen Angelika Amon Adam Abate Pia Adelroth Erol Akcay Karen Allen Hubert Amrein Abul Abbas David Adelson Mark Akeson Lisa Allen Serge Amselem Tarek Abbas Alan Aderem Anna Akhmanova Nicola Allen Derk Amsen Jonathan Abbatt Neil Adger Shizuo Akira Paul Allen Esther Amstad Shahal Abbo Noam Adir Ramesh Akkina Philip Allen I. Jonathan Amster Patrick Abbot Jess Adkins Klaus Aktories Toby Allen Ronald Amundson Albert Abbott Elizabeth Adkins-Regan Muhammad Alam James Allison Katrin Amunts Geoff Abbott Roee Admon Eric Alani Mead Allison Myron Amusia Larry Abbott Walter Adriani Pietro Alano Isabel Allona Gynheung An Nicholas Abbott Ruedi Aebersold Cedric Alaux Robin Allshire Zhiqiang An Rasha Abdel Rahman Ueli Aebi Maher Alayyoubi Abigail Allwood Ranjit Anand Zalfa Abdel-Malek Martin Aeschlimann Richard Alba Julian Allwood Beau Ances Minori Abe Ruslan Afasizhev Salim Al-Babili Eric Alm David Andelman Kathryn Abel Markus Affolter Salvatore Albani Benjamin Alman John Anderies Asa Abeliovich Dritan Agalliu Silas Alben Steven Almo Gregor Anderluh John Aber David Agard Mark Alber Douglas Almond Bogi Andersen Geoff Abers Aneel Aggarwal Reka Albert Genevieve Almouzni George Andersen Rohan Abeyaratne Anurag Agrawal R. Craig Albertson Noga Alon Gregers Andersen Susan Abmayr Arun Agrawal Roy Alcalay Uri Alon Ken Andersen Ehab Abouheif Paul Agris Antonio Alcami Claudio Alonso Olaf Andersen Soman Abraham H. -
Technical Note Q-Learning
Machine Learning, 8, 279-292 (1992) © 1992 Kluwer Academic Publishers, Boston. Manufactured in The Netherlands. Technical Note Q-Learning CHRISTOPHER J.C.H. WATKINS 25b Framfield Road, Highbury, London N5 1UU, England PETER DAYAN Centre for Cognitive Science, University of Edinburgh, 2 Buccleuch Place, Edinburgh EH8 9EH, Scotland Abstract. ~-learning (Watkins, 1989) is a simpleway for agentsto learn how to act optimallyin controlledMarkovian domains. It amounts to an incremental method for dynamic programming which imposes limited computational demands. It works by successivelyimproving its evaluationsof the quality of particular actions at particular states. This paper presents and proves in detail a convergencetheorem for ~-learning based on that outlined in Watkins (1989). We show that 0~-learningconverges to the optimum action-valueswith probability 1 so long as all actions are repeatedly sampled in all states and the action-values are represented discretely. We also sketch extensions to the cases of non-discounted, but absorbing, Markov environments, and where many O~values can be changed each iteration, rather than just one. Keywords. 0~-learning, reinforcement learning, temporal differences, asynchronous dynamic programming 1. Introduction O~-learning (Watkins, 1989) is a form of model-free reinforcement learning. It can also be viewed as a method of asynchronous dynamic programming (DP). It provides agents with the capability of learning to act optimally in Markovian domains by experiencing the con- sequences of actions, without requiring them to build maps of the domains. Learning proceeds similarly to Sutton's (1984; 1988) method of temporal differences (TD): an agent tries an action at a particular state, and evaluates its consequences in terms of the immediate reward or penalty it receives and its estimate of the value of the state to which it is taken. -
Human Functional Brain Imaging 1990–2009
Portfolio Review Human Functional Brain Imaging 1990–2009 September 2011 Acknowledgements The Wellcome Trust would like to thank the many people who generously gave up their time to participate in this review. The project was led by Claire Vaughan and Liz Allen. Key input and support was provided by Lynsey Bilsland, Richard Morris, John Williams, Shewly Choudhury, Kathryn Adcock, David Lynn, Kevin Dolby, Beth Thompson, Anna Wade, Suzi Morris, Annie Sanderson, and Jo Scott; and Lois Reynolds and Tilli Tansey (Wellcome Trust Expert Group). The views expressed in this report are those of the Wellcome Trust project team, drawing on the evidence compiled during the review. We are indebted to the independent Expert Group and our industry experts, who were pivotal in providing the assessments of the Trust’s role in supporting human functional brain imaging and have informed ‘our’ speculations for the future. Finally, we would like to thank Professor Randy Buckner, Professor Ray Dolan and Dr Anne-Marie Engel, who provided valuable input to the development of the timelines and report. The2 | Portfolio Wellcome Review: Trust Human is a Functional charity registeredBrain Imaging in England and Wales, no. 210183. Contents Acknowledgements 2 Key abbreviations used in the report 4 Overview and key findings 4 Landmarks in human functional brain imaging 10 1. Introduction and background 12 2 Human functional brain imaging today: the global research landscape 14 2.1 The global scene 14 2.2 The UK 15 2.3 Europe 17 2.4 Industry 17 2.5 Human brain imaging -
The Experimental Psychology Bulletin: June 2017
The Bulletin of The Society for Experimental Psychology and Cognitive Sciences June 2017 In this issue… pp 2 – 4 APA Convention Program pp 5 – 6 President’s Column: Advocating for Psychological Science p 8 Marching for Science pp 12 – 13 Reaching Out pp 14 – 15 SEPCS Lifetime Achievement Awards pp 16 – 17 SEPCS Early Career Achievement Awards SEPCS in the wild! pp 8 – 10 SEPCS Marching for Science! pp 12 – 13 SEPCS at SEPA and SSPP! Get the word out! Submit op-eds, photos, news, awards, advice, and more to Will Whitham at [email protected] You’re Invited! 125th APA Annual Convention Washington D. C. August 3rd through 6th! 2 Invited Address Paul Merritt (Georgetown University) If You Want to Rule the World, Become a Cognitive Psychologist! SEPCS Lifetime Achievement Award Morton Ann Gernsbacher (University of Wisconsin – Madison) Use of Laptops in College Classrooms: What do the Data Really Suggest? Invited Address Adam Green (Georgetown University) Cognitive & Neural Intervention to Enhance Creativity in Relational Thinking and Reasoning Presidential Address Anne Cleary (Colorado State University) How Metacognitive States Like Tip-of-the-Tongue and Déjà Vu Can Be Biasing 3 Symposium: Cognitive Science & Education Policy Chair: Robert Bjork (UCLA) Participants: Jeffrey Karpicke (Purdue University) Ian Lyons (Georgetown University) Kenneth Maton (University of Maryland, Baltimore County) Skill Building Session Using Technology to Easily Implement Testing Enhanced Learning Facilitated by Paul Merritt & Kruti Vekaria (Georgetown University) Juan Ventura, a Cognitive and Brain Sciences Ph.D. student at LSU, won the 2017 APA Travel Award and Ungerleider/Zimbardo Travel Scholarship. The Ungerleider/Zimbardo Travel Scholarship is awarded to the top 7 applicants of the APA Travel Award. -
Intelligence and Artificial Intelligence
We invite applications to participate in the 4th Intercontinental Academia dedicated to Intelligence and Artificial Intelligence Opening online session: 13-18 June 2021 1st workshop in Paris, France: 18-27 October 2021 2nd workshop in Belo Horizonte, Brazil: 6-15 June 2022 Call for fellows Deadline: March 31, 2021 (6 pm CET) The Intercontinental Academia (ICA) seeks to create a global network of future research leaders in which some of the very best early/mid-career scholars will work together on paradigm-shifting cross-disciplinary research, mentored by some of the most eminent researchers from across the globe. In order to achieve this high objective, we organize in a year three immersive and intense sessions. The experience is expected to transform the scholar's own approach to research, enhance their awareness of the work, relevance and potential impact of other disciplines, and to inspire and facilitate new collaborations between distant disciplines. Our aim is to make a real, yet volatile, intellectual cocktail that leads to meaningful exchange and long-lasting outputs. The theme Intelligence and Artificial Intelligence have been selected to provide a framework for stimulating intellectual exchange in 2021-2022. The past decades have witnessed an impressive progress in cognitive science, neuroscience and artificial intelligence. Beside the decisive scientific advances that have been accomplished in the analysis of brain activity and its behavioral counterparts or in the information processing sciences (machine learning, wearable sensors…), several fundamental and broader questions of deep interdisciplinary nature have been arising. As artificial intelligence and neuroscience/cognitive science seem to show significant complementarities, a key question is to inquire to which extent these complementarities should drive research in both areas and how to optimize synergies. -
Active Inference on Discrete State-Spaces – a Synthesis
ACTIVE INFERENCE ON DISCRETE STATE-SPACES – A SYNTHESIS APREPRINT Lancelot Da Costa1;2;∗, Thomas Parr2, Noor Sajid2, Sebastijan Veselic2, Victorita Neacsu2, Karl Friston2 1Department of Mathematics, Imperial College London 2Wellcome Centre for Human Neuroimaging, University College London March 31, 2020 ABSTRACT Active inference is a normative principle underwriting perception, action, planning, decision-making and learning in biological or artificial agents. From its inception, its associated process theory has grown to incorporate complex generative models, enabling simulation of a wide range of complex behaviours. Due to successive developments in active inference, it is often difficult to see how its underlying principle relates to process theories and practical implementation. In this paper, we try to bridge this gap by providing a complete mathematical synthesis of active inference on discrete state-space models. This technical summary provides an overview of the theory, derives neuronal dynamics from first principles and relates this dynamics to biological processes. Furthermore, this paper provides a fundamental building block needed to understand active inference for mixed gener- ative models; allowing continuous sensations to inform discrete representations. This paper may be used as follows: to guide research towards outstanding challenges, a practical guide on how to im- plement active inference to simulate experimental behaviour, or a pointer towards various in-silico neurophysiological responses that may be used to make empirical predictions. Keywords: active inference, free energy principle, process theory, variational Bayesian inference, Markov decision process, explained. Contents 1 Introduction 2 arXiv:2001.07203v2 [q-bio.NC] 28 Mar 2020 2 Active inference 4 3 Discrete state-space generative models 5 4 Variational Bayesian inference 7 4.1 Free energy and model evidence .