molecules Article Comparisons of In Vivo and In Vitro Opioid Effects of Newly Synthesized 14-Methoxycodeine-6-O-sulfate and Codeine-6-O-sulfate Ferenc Zádor 1,2, Amir Mohammadzadeh 1, Mihály Balogh 1, Zoltán S. Zádori 1 , Kornél Király 1, Szilvia Barsi 1 , Anna Rita Galambos 1, Szilvia B. László 1, Barbara Hutka 1, András Váradi 3, Sándor Hosztafi 3,Pál Riba 1,Sándor Benyhe 2, Susanna Fürst 1 and Mahmoud Al-Khrasani 1,* 1 Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Semmelweis University, Nagyvárad tér 4, P.O. Box 370, H-1445 Budapest, Hungary;
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[email protected]; Tel.: +36-1-2104-416 Received: 15 February 2020; Accepted: 15 March 2020; Published: 17 March 2020 Abstract: The present work represents the in vitro (potency, affinity, efficacy) and in vivo (antinociception, constipation) opioid pharmacology of the novel compound 14-methoxycodeine-6- O-sulfate (14-OMeC6SU), compared to the reference compounds codeine-6-O-sulfate (C6SU), codeine and morphine.