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University of Bath PHD The extraction and chemistry of the metabolites of Mimosa tenuiflora and Papaver somniferum Ninan, Aleyamma Award date: 1990 Awarding institution: University of Bath Link to publication Alternative formats If you require this document in an alternative format, please contact: [email protected] General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal ? Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Download date: 23. Sep. 2021 THE EXTRACTION AND CHEMISTRY OF THE METABOLITES OF MIMOSA TENUIFLORA AND PAP AVER SOMNIFERUM. submitted by ALEYAMMA NINAN for the degree of Doctor of Philosophy of the University of Bath 1990 Attention is drawn to the fact that the copyright of this thesis rests with its author. This copy of the thesis has been supplied on condition that anyone who consults it is understood to recognise that its copyright rests with its author and that no quotation from the thesis and no information derived from it may be published without prior consent of the author. -
Phylogeography of a Tertiary Relict Plant, Meconopsis Cambrica (Papaveraceae), Implies the Existence of Northern Refugia for a Temperate Herb
Article (refereed) - postprint Valtueña, Francisco J.; Preston, Chris D.; Kadereit, Joachim W. 2012 Phylogeography of a Tertiary relict plant, Meconopsis cambrica (Papaveraceae), implies the existence of northern refugia for a temperate herb. Molecular Ecology, 21 (6). 1423-1437. 10.1111/j.1365- 294X.2012.05473.x Copyright © 2012 Blackwell Publishing Ltd. This version available http://nora.nerc.ac.uk/17105/ NERC has developed NORA to enable users to access research outputs wholly or partially funded by NERC. Copyright and other rights for material on this site are retained by the rights owners. Users should read the terms and conditions of use of this material at http://nora.nerc.ac.uk/policies.html#access This document is the author’s final manuscript version of the journal article, incorporating any revisions agreed during the peer review process. Some differences between this and the publisher’s version remain. You are advised to consult the publisher’s version if you wish to cite from this article. The definitive version is available at http://onlinelibrary.wiley.com Contact CEH NORA team at [email protected] The NERC and CEH trademarks and logos (‘the Trademarks’) are registered trademarks of NERC in the UK and other countries, and may not be used without the prior written consent of the Trademark owner. 1 Phylogeography of a Tertiary relict plant, Meconopsis cambrica 2 (Papaveraceae), implies the existence of northern refugia for a 3 temperate herb 4 Francisco J. Valtueña*†, Chris D. Preston‡ and Joachim W. Kadereit† 5 *Área de Botánica, Facultad deCiencias, Universidad de Extremadura, Avda. de Elvas, s.n. -
“Biosynthesis of Morphine in Mammals”
“Biosynthesis of Morphine in Mammals” D i s s e r t a t i o n zur Erlangung des akademischen Grades Doctor rerum naturalium (Dr. rer. nat.) vorgelegt der Naturwissenschaftlichen Fakultät I Biowissenschaften der Martin-Luther-Universität Halle-Wittenberg von Frau Nadja Grobe geb. am 21.08.1981 in Querfurt Gutachter /in 1. 2. 3. Halle (Saale), Table of Contents I INTRODUCTION ........................................................................................................1 II MATERIAL & METHODS ........................................................................................ 10 1 Animal Tissue ....................................................................................................... 10 2 Chemicals and Enzymes ....................................................................................... 10 3 Bacteria and Vectors ............................................................................................ 10 4 Instruments ........................................................................................................... 11 5 Synthesis ................................................................................................................ 12 5.1 Preparation of DOPAL from Epinephrine (according to DUNCAN 1975) ................. 12 5.2 Synthesis of (R)-Norlaudanosoline*HBr ................................................................. 12 5.3 Synthesis of [7D]-Salutaridinol and [7D]-epi-Salutaridinol ..................................... 13 6 Application Experiments ..................................................................................... -
Status and Protection of Globally Threatened Species in the Caucasus
STATUS AND PROTECTION OF GLOBALLY THREATENED SPECIES IN THE CAUCASUS CEPF Biodiversity Investments in the Caucasus Hotspot 2004-2009 Edited by Nugzar Zazanashvili and David Mallon Tbilisi 2009 The contents of this book do not necessarily reflect the views or policies of CEPF, WWF, or their sponsoring organizations. Neither the CEPF, WWF nor any other entities thereof, assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, product or process disclosed in this book. Citation: Zazanashvili, N. and Mallon, D. (Editors) 2009. Status and Protection of Globally Threatened Species in the Caucasus. Tbilisi: CEPF, WWF. Contour Ltd., 232 pp. ISBN 978-9941-0-2203-6 Design and printing Contour Ltd. 8, Kargareteli st., 0164 Tbilisi, Georgia December 2009 The Critical Ecosystem Partnership Fund (CEPF) is a joint initiative of l’Agence Française de Développement, Conservation International, the Global Environment Facility, the Government of Japan, the MacArthur Foundation and the World Bank. This book shows the effort of the Caucasus NGOs, experts, scientific institutions and governmental agencies for conserving globally threatened species in the Caucasus: CEPF investments in the region made it possible for the first time to carry out simultaneous assessments of species’ populations at national and regional scales, setting up strategies and developing action plans for their survival, as well as implementation of some urgent conservation measures. Contents Foreword 7 Acknowledgments 8 Introduction CEPF Investment in the Caucasus Hotspot A. W. Tordoff, N. Zazanashvili, M. Bitsadze, K. Manvelyan, E. Askerov, V. Krever, S. Kalem, B. Avcioglu, S. Galstyan and R. Mnatsekanov 9 The Caucasus Hotspot N. -
Morphine Julie Brousseau a Thesis Submitted
Synthesis of Carbocycles Using Coinage Metal Catalysis and Formal Synthesis of (±)-Morphine Julie Brousseau A thesis submitted in partial fulfillment of the requirements for the Doctorate in Philosophy degree in Chemistry Department of Chemistry and Biomolecular Sciences Faculty of Science University of Ottawa © Julie Brousseau, Ottawa, Canada, 2020 ABSTRACT Coinage metals such as copper, silver and gold have captivated mankind with their desirable qualities and social value. Recently, these metals have peaked the interests of scientists, where organic chemists have used them extensively in the homogenous catalysis of organic transformations. In our laboratory, we exploited their � -Lewis acidic properties to activate alkyne to induce intramolecular cyclization of nucleophilic enol ethers. We discovered that modulating the steric and electronic profiles of the ancillary ligand on the cationic metal complexes allowed for the regioselective control of such reactions. During the exploration of the substrate dependency of these transformations, we discovered that unsubstituted alkynes undergo a 6-endo-dig/acetalization/Prins reaction cascade in the presence of a silver salt such as [(BrettPhos)Ag(MeCN)]SbF6, resulting in the formation of highly strained polycycles. We have demonstrated that the formation of these products is initiated by a selective 6-endo-dig cyclization. Further mechanistic studies suggested that the reaction may occur through silver dual catalysis using deuterium-labelling experiments, however, single activation of the starting material would lead to the same product and thus both mechanisms were proposed. The further reactivity of these interesting polycyclic products was also explored. ii OTIPS R2 O OTIPS R1 [(BrettPhos)Ag(MeCN)]SbF6 (10 mol%) DCM, 60°C, 36h R1 9 Examples O R2 23-95% Yields Via O H/[Ag] R1 [Ag] O R2 Total synthesis of natural products is often referred to as an art, as it defines the boundaries of organic chemistry. -
Morphinone Reductase for the Preparation Of
Europäisches Patentamt *EP000649465B1* (19) European Patent Office Office européen des brevets (11) EP 0 649 465 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) Int Cl.7: C12N 9/02, C12P 17/18, of the grant of the patent: C12Q 1/32 24.07.2002 Bulletin 2002/30 (86) International application number: (21) Application number: 93913236.1 PCT/GB93/01129 (22) Date of filing: 28.05.1993 (87) International publication number: WO 94/00565 (06.01.1994 Gazette 1994/02) (54) MORPHINONE REDUCTASE FOR THE PREPARATION OF HYDROMORPHONE AND HYDROCODONE MORPHINONE REDUKTASE ZUR HERSTELLUNG VON HYDROMORPHONE UND HYDROCODONE MORPHINONE REDUCTASE DESTINEE A LA PREPARATION D’HYDROMORPHONE ET D’HYDROCODONE (84) Designated Contracting States: (74) Representative: Perry, Robert Edward AT BE CH DE DK ES FR GB IE IT LI NL PT SE GILL JENNINGS & EVERY Broadgate House (30) Priority: 25.06.1992 GB 9213524 7 Eldon Street London EC2M 7LH (GB) (43) Date of publication of application: 26.04.1995 Bulletin 1995/17 (56) References cited: WO-A-90/13634 (73) Proprietor: MACFARLAN SMITH LIMITED Edinburgh EH11 2QA (GB) • THE BIOCHEMICAL JOURNAL vol. 274, no. 3, 15 March 1991, pages 875 - 880 NEIL C. BRUCE ET (72) Inventors: AL. ’Microbial degradation of the morphine • HAILES, Anne, Maria 59 Lower Road alkaloids. Purification and characterization of Kent DA8 1AY (GB) morphine dehydrogenase from Pseudomonas • FRENCH, Christopher, Edward putida M10’ Palmerston North (NZ) • BRUCE, Neil, Charles Cambridge CB2 1ND (GB) Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. -
A Systematic Review on Main Chemical Constituents of Papaver Bracteatum
Journal of Medicinal Plants A Systematic Review on Main Chemical Constituents of Papaver bracteatum Soleymankhani M (Ph.D. student), Khalighi-Sigaroodi F (Ph.D.)*, Hajiaghaee R (Ph.D.), Naghdi Badi H (Ph.D.), Mehrafarin A (Ph.D.), Ghorbani Nohooji M (Ph.D.) Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran * Corresponding author: Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, P.O.Box: 33651/66571, Karaj, Iran Tel: +98 - 26 - 34764010-9, Fax: +98 - 26-34764021 E-mail: [email protected] Received: 17 April 2013 Accepted: 12 Oct. 2014 Abstract Papaver bracteatum Lindly (Papaveraceae) is an endemic species of Iran which has economic importance in drug industries. The main alkaloid of the plant is thebaine which is used as a precursor of the semi-synthetic and synthetic compounds including codeine and naloxone, respectively. This systematic review focuses on main component of Papaver bracteatum and methods used to determine thebaine. All studies which assessed the potential effect of the whole plant or its extract on clinical or preclinical studies were reviewed. In addition, methods for determination of the main components, especially thebaine, which have been published from 1948 to March 2013, were included. Exclusion criteria were agricultural studies that did not assess. This study has listed alkaloids identified in P. bracteatum which reported since 1948 to 2013. Also, the biological activities of main compounds of Papaver bracteatum including thebaine, isothebaine, (-)-nuciferine have been reviewed. As thebaine has many medicinal and industrial values, determination methods of thebaine in P. bracteatum were summarized. The methods have being used for determination of thebaine include chromatographic (HPLC, GC and TLC) and non chromatographic methods. -
Index Seminum Et Sporarum Quae Hortus Botanicus Universitatis Biarmiensis Pro Mutua Commutatione Offert
INDEX SEMINUM ET SPORARUM QUAE HORTUS BOTANICUS UNIVERSITATIS BIARMIENSIS PRO MUTUA COMMUTATIONE OFFERT Salix recurvigemmata A.K. Skvortsov f. variegata Schumikh., O.E. Epanch. & I.V. Belyaeva Biarmiae 2020 Federal State Autonomous Educational Institution of Higher Education «Perm State National Research University», A.G. Genkel Botanical Garden ______________________________________________________________________________________ СПИСОК СЕМЯН И СПОР, ПРЕДЛАГАЕМЫХ ДЛЯ ОБМЕНА БОТАНИЧЕСКИМ САДОМ ИМЕНИ А.Г. ГЕНКЕЛЯ ПЕРМСКОГО ГОСУДАРСТВЕННОГО НАЦИОНАЛЬНОГО ИССЛЕДОВАТЕЛЬСКОГО УНИВЕРСИТЕТА Syringa vulgaris L. ‘Красавица Москвы’ Пермь 2020 Index Seminum 2020 2 Federal State Autonomous Educational Institution of Higher Education «Perm State National Research University», A.G. Genkel Botanical Garden ______________________________________________________________________________________ Дорогие коллеги! Ботанический сад Пермского государственного национального исследовательского университета был создан в 1922 г. по инициативе и под руководством проф. А.Г. Генкеля. Здесь работали известные ученые – ботаники Д.А. Сабинин, В.И. Баранов, Е.А. Павский, внесшие своими исследованиями большой вклад в развитие биологических наук на Урале. В настоящее время Ботанический сад имени А.Г. Генкеля входит в состав регионального Совета ботанических садов Урала и Поволжья, Совет ботанических садов России, имеет статус научного учреждения и особо охраняемой природной территории. Основными научными направлениями работы являются: интродукция и акклиматизация растений, -
Effect of Anticancer Agents on Codeinone-Induced Apoptosis in Human Cancer Cell Lines
ANTICANCER RESEARCH 25: 4037-4042 (2005) Effect of Anticancer Agents on Codeinone-induced Apoptosis in Human Cancer Cell Lines RISA TAKEUCHI1,2, HIROSHI HOSHIJIMA1,2, NORIKO ONUKI1,2, HIROSHI NAGASAKA1, SHAHEAD ALI CHOWDHURY3, MASAMI KAWASE4 and HIROSHI SAKAGAMI2 1Division of Anesthesiology, Department of Comprehensive Medical Sciences, 2Division of Pharmacology, Department of Diagnostic and Therapeutic Sciences, and 3MPL (Meikai Phamaco-Medical Laboratory), Meikai University School of Dentistry, Sakado, Saitama 350-0283; 4Faculty of Phamaceutical Sciences, Josai University, Sakado, Saitama 350-0295, Japan Abstract. The possible apoptosis-inducing activity of Opioids have been given to patients with cancer pain, codeinone, an oxidative metabolite of codeine, without or according to the WHO ladder against pain (4). According with anticancer drugs, was investigated. Codeinone induced to reports of Ventafridda et al., pain occurs in more than internucleosomal DNA fragmentation in human 50% of cancer patients, and the administration of opioids promyelocytic leukemia cells (HL-60), but not in human manifests significantly higher therapeutic effects against squamous cell carcinoma cells (HSC-2). Codeinone dose- cancer pain, compared with non-narcotics (5, 6). Although dependently activated caspase-3 in both of these cells, but to opioids have been used for patients in clinical situations, the a much lesser extent than that attained by actinomycin D. anticancer action of opioids has not been well investigated. This property of codeinone was similar to what we have Both opioids and anticancer drugs have been simultaneously found previously in ·,‚-unsaturated ketones. Codeinone did given for pain in cancer patients. However, there has been not activate caspase-8 or caspase-9 in these cells. -
In Vitro Regeneration of Persian Poppy (Papaver Bracteatum)
Biologia 65/4: 647—652, 2010 Section Cellular and Molecular Biology DOI: 10.2478/s11756-010-0079-6 In vitro regeneration of Persian poppy (Papaver bracteatum) Sara Rostampour1,2,HalehHashemi Sohi1*&AliDehestani3 1Department of Plant Biotechnology, National Institute of Genetic Engineering and Biotechnology, P.O. Box 14155–6343 Tehran, Iran; e-mail: [email protected] 2Department of Agronomy and Plant Breeding, University of Zabol, Zabol, Iran 3Department of Plant Breeding, Faculty of Agronomic Sciences, Sari Agricultural Sciences and Natural Resources Univer- sity, Sari, Iran Abstract: Persian poppy (Papaver bracteatum Lindl.) is an important commercial source of medicinal opiates and related compounds. In this research, calli were induced from seeds, roots, cotyledons and hypocotyls of P. bracteatum at a high efficiency. The optimized callus induction media consisted of the Murashige and Skoog (MS) basic media supplemented with 1.0 mg/L 2, 4-dichlorophenoxyacetic acid (2,4-D), 0.1 mg/L kinetin and 15 mg/L ascorbic acid. The concentrations of 2,4-D and ascorbic acid were found critical to callus induction and proliferation. Subsequent subcultures resulted in excellent callus proliferation. Ascorbic acid at concentration 15 mg/L increased the callus proliferation significantly. Maximum callus growth was achieved when the explants were incubated at 25 ◦C. MS salts at full strength were found inhibitory for callus induction, while ľ MS salts were found to favor callus induction. Shoot regeneration of calli in vitro wasachievedonľ MS medium containing 0.5 mg/L benzylamine purine and 1.0 mg/L naphthalene acetic acid. Analysis of alkaloid extracts from Persian poppy tissues by high-performance liquid chromatography showed that thebaine accumulated in the tissues of plants. -
Feasibility Study on Opium Licensing in Afghanistan
FEASIBILITY STUDY ON OPIUM LICENSING IN AFGHANISTAN FOR THE PRODUCTION OF MORPHINE AND OTHER ESSENTIAL MEDICINES ﻣﻄﺎﻟﻌﻪ اﻣﮑﺎﻧﺎت در ﻣﻮرد ﺟﻮاز دهﯽ ﺗﺮﻳﺎک در اﻓﻐﺎﻧﺴﺘﺎن ﺑﺮای ﺗﻮﻟﻴﺪ ﻣﻮرﻓﻴﻦ و ادوﻳﻪ ﺟﺎت ﺿﺮوری دﻳﮕﺮ Initial Findings – September 2005 Kabul, Afghanistan The British Institute of International and Comparative Law Hugo Warner • University of Calgary Peter Facchini - Jill Hagel University of Ghent Brice De Ruyver - Laurens van Puyenbroeck University of Kabul Abdul Aziz Ali Ahmad - Osman Babury Cheragh Ali Cheragh - Mohammad Yasin Mohsini University of Lisbon Vitalino Canas - Nuno Aureliano • Shruti Patel • University of Toronto Benedikt Fischer Todd Culbert - Juergen Rehm • Wageningen University Jules Bos - Suzanne Pegge • Ali Wardak • The Senlis Council Gabrielle Archer - Juan Arjona - Luke Bryant Marc Das Gupta - Furkat Elmirzaev - Guillaume Fournier Jane Francis - Thalia Ioannidou - Ernestien Jensema Manna Kamio Badiella - Jorrit Kamminga - Fabrice Pothier Emmanuel Reinert - David Spivack - Daniel Werb FEASIBILITY STUDY ON OPIUM LICENSING IN AFGHANISTAN FOR THE PRODUCTION OF MORPHINE AND OTHER ESSENTIAL MEDICINES Initial Findings – September 2005 Kabul, Afghanistan Study Commissioned by The Senlis Council Study Edited and coordinated by David Spivack Editorial team: Juan Arjona, Jane Francis, Thalia Ioannidou, Ernestien Jensema, Manna Kamio Badiella, Fabrice Pothier. Published 2005 by MF Publishing Ltd 17 Queen Anne’s Gate, London SW1H 9BU, UK ISBN: 0-9550798-2-9 Printed and bound in Afghanistan by Jehoon; Printing Press Other publications -
Mohn (Papaver Somniferum
Mohn (Papaver somniferum L.) Synonyme (Namen dieser Pflanze in allen 76 Sprachen anzeigen) pharmazeutisch Semen Papaveris Albanisch Lulëkuqe Μήκων Altgriechisch Mekon ፓፓ Amharisch Papi , Arabisch , Khashkhash, Abu an-num, Abu al-num, Abu an-noom, Abu al-noom Մեկոն, Մեկոնի Կուտ Armenisch Mekon, Megon; Mekoni Kut, Megoni Good (Samen) Assamesisch Xaş-xaş Azeri Хаш-хаш Baskisch Lobelarr Bengali Градински мак, Опиев мак, Маково семе Bulgarisch Gradinski mak, Opiev mak; Makovo seme (Samen) Burmesisch Chinesisch 櫻粟殼 [yìng suhk hohk] (Kantonesisch) Ying suhk hohk Chinesisch 櫻粟殼 [yīng sù qiào], 罂粟 [yīng sù] (Mandarin) Ying su qiao, Ying su Dänisch Opiumvalmue (Pflanze); Birkes, Valmue-frø (Samen) Deutsch Schlafmohn, Gartenmohn, Ölmohn, Opiummohn, , Dhivehi Afihun, Kaskasaa Englisch Poppy, Opium poppy, Garden poppy Esperanto Papavo, Papavosemo Estnisch Magun, Unimagun, Moon Farsi Khash-khash, Shagheyegh Finnisch Unikko, Oopiumiunikko Französisch Pavot des jardins, Pavot somnifère, Pavot à opium Gälisch Codalion, Paipin Galizisch Mapoula, Sementes de Mapoula, Adormideira, Durmideira ყაყაჩო, ყაყაჩოს თესლი, ხოშხოში Georgisch Khoshkhoshi, Q’aq’acho, Xoshxoshi, Qaqacho; Q’aq’achos tesli, Qaqachos tesli (Samen) Παπαρούνα, Αθιόνι Griechisch Paparouna, Afioni Gujarati Hebräisch Pereg Hindi Irisch Poipín Isländisch Valmúafræ, Birki Italienisch Papavero, Papavero sonnifero 芥子, 罌粟 けし Japanisch ケシ, ポピー Keshi, Papi , Jiddisch Mondl, Mon Kannada Көкнәр Kasachisch Köknär Kashmiri Khash-khash Katalanisch Cascall, Herba dormidora 아편, 포피, 양귀비 Koreanisch Apyeon, Apyon,