The Monster at Our Door Also by Mike Davis
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'Spanish' Influenza
1918 ‘Spanish’ Influenza: Lessons from the Past Jeffery Taubenberger, M.D., Ph.D. May 1, 2012 Influenza A virus (IAV) Family: Orthomyxoviridae •Negative sense, segmented, single-stranded RNA genome •8 segments, 12-13 ORF’s NA NA (9 NA subtypes) Nomenclature: SA ααα2-6Gal e.g., H5N1, H3N2 HA SA ααα2-3Gal (17 HA subtypes) Modified from: Horimoto & Kawaoka (2005) Nat Rev Micro 3:591-600 “Shift and Drift” Influenza A virus host range is quite diverse ? Influenza A viruses in animals Influenza A viruses in humans Annual epidemics with >200,000 hospitalizations; & up to 49,000 deaths/yr. in U.S. Occasional and unpredictable pandemic strains with increase in illness and death Pandemics are derived zoonotically: 1918, 1957, 1968, 2009 Morens, et al . 2009 NEJM . 361:225-229 The influenza problem: Influenza New strains pandemics emerge continually emerge; unpredictably and host range is very have variable extensive characteristics Human influenza A timeline H1N1 H3N2 H3N? H2N2 H1N1 H1N1 1889 1918 1957 1977 2009 1968 N = 4 Mortality impacts of past influenza pandemics Influenza pandemics throughout history • At least 14 pandemics in last 500 years (since 1510) • Average inter-pandemic interval = 36 years • Severity variable Morens & Taubenberger 2011. Rev Med Virol 21:262 1918 ‘Spanish’ influenza mortality • Total deaths in the 9 months of the pandemic in 1918-1919 estimated to be 50 million • U.S. Deaths = 675,000 • U.S. Military deaths to flu = 43,000 (out of ~100,000 U.S. Troop casualties in W.W.I.) • Case fatality rate ~1-2%; >98% had self-limited -
London's Swine Flu Pandemic
Central and North West London NHS Foundation Trust Executive Office Tel: 020 3214 5760 Fax: 020 3214 5761 4 February 2010 Sarah Hurcombe Assistant Scrutiny Manager Post Point 10 City Hall The Queen's Walk London SE1 2AA Dear Ms Hurcombe, I am responding to your request for feedback in relation to London's response to Swine Flu. !asked my Director of Nursing Practice, who is our Infection Control lead, to consider the questions you asked and he has provided me with the following comments: 1. Communication was a bit of an issue at first but this improved rapidly in time. I generally found that staff at NHS London were doing their best to advise where they could. Teleconferencing was a big help and saved a lot of travel time. One final point is that there wasn't any panic at any time when it was declared to be a pandemic. 2. At some of the meetings members of NHS London could become rather defensive to constructive comments. They appeared to take these as personal attacks. A more open debate on the challenges we were all facing would have been helpful. I hope that the above comments are useful. We look forward to viewing others views and feedback when published on your web-site. Yours sincerely, Claire Murdoch Chief Executive Trust Headquarters, Greater London House, Hampstead Road, London NWl 7QY Tel: 020 3214 5700 Fax: 020 3214 5701 www.cnwi.nhs.uk Dear Sarah, Further to the letter from James Cleverly, Chair of Health and Public Services Committee, and in answer to the questions posed: The Ealing Hospital NHS Trust has yet to complete its local debrief, but in general we believe we responded well to the challenge. -
2019 Icar Program & Abstracts Book
Hosted by the International Society for Antiviral Research (ISAR) ND International Conference 32on Antiviral Research (ICAR) Baltimore MARYLAND PROGRAM and USA Hyatt Regency BALTIMORE ABSTRACTS May 12-15 2019 ND TABLE OF International Conference CONTENTS 32on Antiviral Research (ICAR) Daily Schedule . .3 Organization . 4 Contributors . 5 Keynotes & Networking . 6 Schedule at a Glance . 7 ISAR Awardees . 10 The 2019 Chu Family Foundation Scholarship Awardees . 15 Speaker Biographies . 17 Program Schedule . .25 Posters . 37 Abstracts . 53 Author Index . 130 PROGRAM and ABSTRACTS of the 32nd International Conference on Antiviral Research (ICAR) 2 ND DAILY International Conference SCHEDULE 32on Antiviral Research (ICAR) SUNDAY, MAY 12, 2019 › Women in Science Roundtable › Welcome and Keynote Lectures › Antonín Holý Memorial Award Lecture › Influenza Symposium › Opening Reception MONDAY, MAY 13, 2019 › Women in Science Award Lecture › Emerging Virus Symposium › Short Presentations 1 › Poster Session 1 › Retrovirus Symposium › ISAR Award of Excellence Presentation › PechaKucha Event with Introduction of First Time Attendees TUESDAY, MAY 14, 2019 › What’s New in Antiviral Research 1 › Short Presentations 2 & 3 › ISAR Award for Outstanding Contributions to the Society Presentation › Career Development Panel › William Prusoff Young Investigator Award Lecture › Medicinal Chemistry Symposium › Poster Session 2 › Networking Reception WEDNESDAY, MAY 15, 2019 › Gertrude Elion Memorial Award Lecture › What’s New in Antiviral Research 2 › Shotgun Oral -
Secret Assassins
.. “BIRD FLU” HOAX EXPOSED A. True Ott, PhD –4/5/06 Exactly 30 years ago, in 1976, National Headlines Proclaimed: “Swine Flu Pandemic Poised to Exceed 1918 Death Toll”. The national news media swept America away in an unprecedented fear-based, propaganda campaign to promote what is now recognized as a tremendous money-making hoax designed to enrich large pharmaceutical houses by selling billions of dollars worth of “Swine Flu Vaccinations” to an ignorant public. What stopped the massive scam? Three factors – 1. A few honest congressmen blew the whistle on the conspirators, 2. A few honest microbiologists and medical doctors also went public with the TRUTH, and 3. a precedent-setting series of lawsuits against Rockefeller’s “Big Five” pharmaceutical/vaccine manufacturing houses were victorious; many recipients of the “vaccine”experienced permanent paralysis and even death –all of this caused by the FDA approved and so-called “Safe, Well Tested Vaccine.” Today, alarmingly, THE EXACT SAME SCRIPT PLAYED IN 1976 is once again unfolding on the World Stage. Many of the “players” are the same. The goals of the conspirators are somewhat different however. Money does NOT appear to be the key issue today –POWER, MANIPULATION AND FASCIST CONTROL OF THE AMERICAN PEOPLE are apparently today the key issues. The Horror Story does not need to be re-written. All one has to do is read and internalize the work honest scientists published in 1976, and the history of the 1918 pandemic. The TRUTH still is TRUTH today, 30 years later. I would personally submit, the stakes are infinitely greater, however. -
Cute, Dangerous Or Both?
[ABCDE] VOLUME 5, ISSUE 6 Cute, Dangerous or Both? ASSOCIATED PRESS Newborn chicks, at a poultry farm in Burgos, northern Spain, might someday be carriers of a disease called bird flu. INSIDE Cause Assessing the Resurrecting $1 Billion 6 for Concern 8 Bird Flu 13 1918 Flu 20 Award July 1, 2006 © 2006 THE WASHINGTON POST COMPANY VOLUME 5, ISSUE 5 An Integrated Curriculum For The Washington Post Newspaper In Education Program Endemic, Epidemic or Pandemic? Health Watch Lesson: As individuals, companies, • Seasonal (or common) flu kills www.who.int/csr/disease/influenza/ health officials and governments thousands each year. It can be pandemic/en/ confront an outbreak of mumps transmitted person to person, but Epidemic and Pandemic Alert and Response and a potential virulent spread most people have some immunity (EPR) of the avian flu, students can to it and a vaccine is available. World Health Organization provides explore public health, privacy • The influenza viruses that cause background and preparedness plans, rights and economic decisions. avian (or bird) flu occur naturally including the WHO global influenza The concerns about avian flu among wild birds. The H5N1 preparedness plan. Latest information on also provide opportunity to teach variant is deadly to domestic situation in countries around the globe. students about the Spanish Flu that fowl and can be transmitted from killed more than 50 million people birds to humans. There is no www.pandemicflu.gov/ around the world and to introduce human immunity and no vaccine PandemicFlu.gov students to careers in virology and is available. U.S. government avian and pandemic flu epidemiology. -
NIH Public Access Author Manuscript Vaccine
NIH Public Access Author Manuscript Vaccine. Author manuscript; available in PMC 2009 September 12. NIH-PA Author ManuscriptPublished NIH-PA Author Manuscript in final edited NIH-PA Author Manuscript form as: Vaccine. 2008 September 12; 26(Suppl 4): D59±D66. doi:10.1016/j.vaccine.2008.07.025. PATHOLOGY OF HUMAN INFLUENZA REVISITED Thijs Kuikena,* and Jeffery Taubenbergerb aDepartment of Virology, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands. bLaboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 33 North Dr, Bethesda, MD 20892-3203 USA. Summary The pathology of human influenza has been studied most intensively during the three pandemics of the last century, the last of which occurred in 1968. It is important to revisit this subject because of the recent emergence of avian H5N1 influenza in humans as well as the threat of a new pandemic. Uncomplicated human influenza virus infection causes transient tracheo-bronchitis, corresponding with predominant virus attachment to tracheal and bronchial epithelial cells. The main complication is extension of viral infection to the alveoli, often with secondary bacterial infection, resulting in severe pneumonia. Complications in extra-respiratory tissues such as encephalopathy, myocarditis, and myopathy occur occasionally. Sensitive molecular and immunological techniques allow us to investigate whether these complications are a direct result of virus infection or an indirect result of severe pneumonia. Human disease from avian influenza virus infections is most severe for subtype H5N1, but also has been reported for H7 and H9 subtypes. In contrast to human influenza viruses, avian H5N1 virus attaches predominantly to alveolar and bronchiolar epithelium, corresponding with diffuse alveolar damage as the primary lesion. -
Surveillance of Influenza a Virus in Environmental Ice and Water Samples
i SURVEILLANCE OF INFLUENZA A VIRUS IN ENVIRONMENTAL ICE AND WATER SAMPLES Gang Zhang A dissertation Submitted to the Graduate College of Bowling Green State University in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY December 2007 Committee: Scott Rogers, Advisor Robert Midden Graduate Faculty Representative Carmen Fioravanti George Bullerjahn John Castello ii ABSTRACT Scott O. Rogers, Advisor Influenza A virus (IAV) is an important human pathogen. IAV infects humans and also a variety of other warm-blooded animals, including various domestic and wild fowl, many domestic and wild mammals. In wild aquatic birds, IAVs primarily are enteric viruses. IAV may have reached evolutionary stasis in birds. As the primary reservoir of all IAV subtypes, wild aquatic fowl play an important role in the ecology of IAV, by maintaining various subtypes of IAV and continuously transmitting genes and viral strains to other host species. Among wild aquatic birds, transmission of IAV occurs through the “oral-fecal” pathway. Environmental ice is a good reservoir for preserving microorganisms alive for long periods of time. In this study, we hypothesized that environmental ice was a good abiotic reservoir for preserving IAV virions shed by wild birds. IAV H1 gene sequences were detected in ice and water samples collected from northeastern Siberian lakes (Lake Park, Lake Edoma). After cloning and sequencing, 83 unique sequences were derived from a Lake Park ice sample and 1 unique sequence was derived from a Lake Edoma water sample. Phylogenetic analysis indicated that the sequences were heterogenous. The sequences shared similarities to IAVs isolated from humans in the 1930s in Europe and in the 1960s in Japan. -
EMERGING BIOLOGICAL THREATS This Page Intentionally Left Blank EMERGING BIOLOGICAL THREATS
EMERGING BIOLOGICAL THREATS This page intentionally left blank EMERGING BIOLOGICAL THREATS A Reference Guide JOAN R. CALLAHAN GREENWOOD PRESS An Imprint of ABC-CLIO, LLC Copyright 2010 by Joan R. Callahan All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, except for the inclusion of brief quotations in a review, without prior permission in writing from the publisher. Library of Congress Cataloging-in-Publication Data Callahan, Joan R. Emerging biological threats : a reference guide / Joan R. Callahan. p. ; cm. Includes bibliographical references and index. ISBN 978-0-313-37209-4 (alk. paper) 1. Emerging infectious diseases. 2. Health risk assessment. 3. Food security. I. Title. [DNLM: 1. Disease Outbreaks—prevention & control. 2. Food Contamination—prevention & control. 3. Hazardous Substances—adverse effects. 4. Public Health—history. WA 105 C156e 2010] RA643.C263 2010 362.196'9—dc22 2009046252 14 13 12 11 10 12345 This book is also available on the World Wide Web as an eBook. Visit www.abc-clio.com for details. ISBN: 978-0-313-37209-4 EISBN: 978-0-313-37210-0 ABC-CLIO, LLC 130 Cremona Drive, P.O. Box 1911 Santa Barbara, California 93116-1911 This book is printed on acid-free paper Manufactured in the United States of America Dedicated to my great-grandfather MICHAEL FOLEY (1849–1897) Born during the Irish Famine Died from an experimental tuberculosis treatment This page intentionally left blank Contents Preface xi 1. Introduction 1 Public Health: A Short History 2 Koch and His Postulates 2 Hazard, Threat, and Risk 2 Outbreaks, Epidemics, and Pandemics 6 What Is Popular Culture? 6 More Definitions 6 So How Bad Is It? 6 2. -
(SARS-Cov-2, 2019-Coronavirus). J Mycol Mycological Sci 2020, 3(1): 000123
Open Access Journal of Mycology & Mycological Sciences ISSN: 2689-7822 MEDWIN PUBLISHERS Committed to Create Value for Researchers The Historical/Evolutionary Cause and Possible Treatment of Pandemic COVID-19 (SARS-CoV-2, 2019-Coronavirus) Niknamian S* Associate Professor of Medicine, John D Dingell VA Medical Center and Wayne State University, Review Article USA Volume 3 Issue 1 Received Date: May 02, 2020 *Corresponding author: Sorush Niknamian, Chief, Division of Infectious Diseases, John D Published Date: June 15, 2020 Dingell VA Medical Center, Associate Professor of Medicine, Wayne State University Detroit, MI DOI: 10.23880/oajmms-16000123 USA, Tel: 313-576-3057; Fax: 313-576-1242; Email: [email protected] Abstract Background: A virus is a small infectious agent that replicates only inside the living cells of an organism. Viruses can infect all types of life forms, from animals and plants to microorganisms, including bacteria and archaea. In evolution, viruses are an important means of horizontal gene transfer, which increases genetic diversity in a way virus. Some viruses especially smallpox, throughout history, has killed between 300-500 million people in its 12,000- analogous to sexual reproduction. Influenza (Including (COVID-19), is an infectious disease caused by an influenza year existence. As modern humans increased in numbers, new infectious diseases emerged, including SARS-CoV-2. We have two groups of virus, RNA and DNA viruses. The most brutal viruses are RNA ones like COVID-19 Sars-CoV-2. Introduction: Coronaviruses are a group of viruses that cause diseases in mammals and birds. In humans, coronaviruses cause respiratory tract infections that are typically mild, such as some cases of the common cold and COVID-19. -
Annals of Medical & Surgical Case Reports
1 Volume 02; Issue 03 ISSN: 2652-4414 Annals of Medical & Surgical Case Reports Research Article Niknamian S and Zaminpira S. Ann Med &Surg Case Rep: AMSCR-100050 The Historical/Evolutionary Cause and Possible Treatment of Pandemic Covid-19 (Sars-Cov-2, 2019-Coronavirus) Niknamian S1* and Zaminpira S2 1Department of Military Medicine,American Military University and Liberty University, USA 2Department of Phycology and Psychiatry,American Beirut University, Beirut, Lebanon *Corresponding author: Sorush Niknamian, Department of Military Medicine, American Military University and Liberty University, USA, Tel: 989121939806; Email: [email protected] Citation: Niknamian S and Zaminpira S (2020) The Historical/Evolutionary Cause and Possible Treatment of Pandemic Covid-19 (Sars-Cov-2, 2019-Coronavirus). Ann Med &Surg Case Rep: AMSCR-100050 Received date: 11 April, 2020; Accepted date: 20 April, 2020; Published date: 27 April, 2020 Abstract Background: A virus is a small infectious agent that replicates only inside the living cells of an organism. Viruses can infect all types of life forms, from animals and plants to microorganisms, including bacteria and archaea. In evolution, viruses are an important means of horizontal gene transfer, which increases genetic diversity in a way analogous to sexual reproduction.Influenza (Including (COVID-19), is an infectious disease caused by an influenza virus. Some viruses especially smallpox, throughout history, has killed between 300-500 million people in its 12,000-year existence.As modern humans increased in numbers, new infectious diseases emerged, including SARS-CoV-2. We have two groups of virus, RNA and DNA viruses. The most brutal viruses are RNA ones like COVID-19 (Sars-CoV-2). -
VIRUSES, PLAGUES, and HISTORY This Page Intentionally Left Blank VIRUSES, PLAGUES, and HISTORY Past, Present, and Future
VIRUSES, PLAGUES, AND HISTORY This page intentionally left blank VIRUSES, PLAGUES, AND HISTORY Past, Present, and Future MICHAEL B. A. OLDSTONE Revised and Updated Edition 1 2010 1 Oxford University Press, Inc., publishes works that further Oxford University’s objective of excellence in research, scholarship, and education. Oxford New York Auckland Cape Town Dar es Salaam Hong Kong Karachi Kuala Lumpur Madrid Melbourne Mexico City Nairobi New Delhi Shanghai Taipei Toronto With offices in Argentina Austria Brazil Chile Czech Republic France Greece Guatemala Hungary Italy Japan Poland Portugal Singapore South Korea Switzerland Thailand Turkey Ukraine Vietnam Copyright c 2010 by Michael B. A. Oldstone Published by Oxford University Press, Inc. 198 Madison Avenue, New York, New York 10016 www.oup.com Oxford is a registered trademark of Oxford University Press All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior permission of Oxford University Press. Library of Congress Cataloging-in-Publication Data Oldstone, Michael B. A. Viruses, plagues, and history : past, present, and future / by Michael B. A. Oldstone. — Rev. and updated ed. p. cm. Includes bibliographical references and index. ISBN 978-0-19-532731-1 1. Virus diseases—History. I. Title. RC114.5.O37 2010 616.9—dc22 2009003550 135798642 Printed in the United States of America on acid-free paper For Betsy, Jenny, Beau, and Chris and six sweethearts, Caroline Anne Aileen Elizabeth Madeleine Rose Faye Annastasia Raina Elizabeth Marilee Kate This page intentionally left blank You need not fear the terror by night, nor the arrow that flies by day, nor the plague that stalks in the darkness. -
Swine Flu Expose by Eleanora I
Eleanora McBean Ph.D., N.D. http://www.whale.to/vaccine/sf.html Quotes "TYPHOID MARY" WAS NEVER A CARRIER by Eleanora I. McBean, Ph.D., N.D. Books [1977] Vaccination, The Silent Killer----Honorof, Ida, and McBean. [1977] Swine Flu Expose by Eleanora I. McBean, Ph.D., N.D. [1957 CLASSIC] THE POISONED NEEDLE by Eleanor McBean [1957] The Hidden Dangers In Polio Vaccine (Chapter 10 of Poisoned Needle) by Eleanor McBean [Home] Swine Flu Expose a book by Eleanora I. McBean, Ph.D., N.D. Chapter 1 Swine Flu--Another Medically-made Epidemic Preface $5,000,000 law suit filed against flu promoters for causing paralysis Swine flu vaccine tests prove unsafe No swine flu epidemic All vaccines are poison Ford the puppet Vaccines can trigger heart attack 80% of all medical doctors are unfit Drugs cannot cure Vaccine promoters try to dodge the blame A few congressmen blast the swine flu hoax How to punish the culprits Law suits against the vaccine promoters American medical Association has been outlawed New Anti-trust suit against the chiropractors 2,000,000 doses of defective swine flu vaccine condemned Many fake findings by scientists seen Swine flu promoters tried to con the swine raisers President Coolidge unswayed by medical pressure God give us men What our leaders should have checked on before throwing us to the killer (vaccine) sharks Question that should have been answered before considering any vaccination drive Death count may never be known Who pockets the money? Compulsory army vaccinations are unconstitutional How will our new President Carter handle the swine flu swindle? Fluoridated tooth paste dangerous A better campaign PREFACE This booklet on Swine Flu hazards and fakery is part of a larger book on vaccination, titled, VACCINATION CONDEMNED BY COMPETENT DOCTORS.