Death toll SNo Location Date Comment Disease (estimate) Known as Plague of Justinian, due to the ca. 40% of 1 Europe 541-2 name of the Byzantine Bubonic Plague population emperor in power at the time. Known as "Black Death" or "Black Plague," first 30% to 70% 1346- return of the plague to 2 of Europe Bubonic plague 50 Europe after the population Justinianic plague of the 6th century. 3 Mexico 1576 Cocolitztli viral hemorrhagic fever Seneca 1592– 4 measles nation 1596 1596– 5 Spain plague 1602 South 1600– 6 malaria America 1650 7 England 1603 London plague 8 Egypt 1609 plague Southern Unknown cause. Latest research suggests New epidemic(s) of leptospirosis with Weil syndrome. 30% to 90% England, 1616– Classic explanations include yellow fever, 9 of especially 1619 bubonic plague, influenza, smallpox, chickenpox, population the typhus, and syndemic infection of hepatitis B and Wampanoag hepatitis D. people 1629– Italian plague of 1629– 10 280,000 Italy plague 1631 1631 Wyandot 11 1630 in Ontario smallpox people Thirteen 12 1633 Plymouth Colony smallpox Colonies Thirteen 13 1634 Connecticut River area smallpox Colonies 14 England 1636 Newcastle plague 1641– helped end the Ming 15 China plague 1644 Dynasty 1647– 16 Spain Great Plague of Seville plague 1652 South 17 1648 yellow fever America 18 Italy 1656 Naples plague Thirteen 19 1657 Boston, Massachusetts measles Colonies 1663– 20 24,148 Netherlands Amsterdam plague 1664 1665– 21 100,000 England Great Plague of London plague 1666 22 40,000 France 1668 plague 1676– 23 Spain plague 1685 24 Austria 1679 Great Plague of Vienna plague Thirteen 25 1687 Boston, Massachusetts measles Colonies Thirteen 26 1690 New York City yellow fever Colonies Canada, 1702– 27 smallpox New France 1703 1710– 28 Sweden Stockholm plague 1711 Thirteen 29 1713 Boston, Massachusetts measles Colonies Thirteen 1713– New England and the 30 measles Colonies 1715 Great Lakes Canada, 1714– 31 measles New France 1715 1720– Great Plague of 32 France plague 1722 Marseille Thirteen 1721– 33 Boston, Massachusetts smallpox Colonies 1722 Thirteen 34 1729 Boston, Massachusetts measles Colonies 35 Spain 1730 Cadiz yellow fever Thirteen 1732– 36 influenza Colonies 1733 Canada, 37 1733 smallpox New France 38 Balkans 1738 Great Plague of 1738 plague Thirteen 39 1738 South Carolina smallpox Colonies Thirteen 1739– 40 Boston, Massachusetts measles Colonies 1740 41 Italy 1743 Messina plague Thirteen 42 1747 CT, NY, PA, SC measles Colonies North 1755– 43 smallpox America 1756 North 44 1759 measles America North 45 America, 1761 influenza West Indies 1770– Russian plague of 1770– 46 Russia plague 1772 1772 Pacific 47 Northwest 1770s smallpox natives North 48 1772 measles America North particularly in the 49 1775 unknown cause America northeast 1775– 50 England influenza 1776 51 Spain 1778 Cadiz dengue fever Plains 1780– North American 52 smallpox Indians 1782 smallpox epidemic Pueblo 53 1788 smallpox Indians United Philadelphia and New 54 1788 measles States York New South 1789– 55 Wales, amongst the Aborigines smallpox 1790 Australia United 56 1793 Vermont influenza and epidemic typhus States United 57 1793 Virginia influenza States United 1793– Yellow Fever Epidemic 58 yellow fever States 1798 of 1793, resurgences 1800– 59 Spain yellow fever 1803 Ottoman 60 Empire, 1801 bubonic plague Egypt United 61 1803 New York yellow fever States 62 Egypt 1812 plague Ottoman 63 1812 Istanbul plague Empire 64 Malta 1813 plague 65 Romania 1813 Bucharest plague 1816– 66 Ireland typhus 1819 Asia, 1816– 67 >>100,000 first cholera pandemic cholera Europe 1826 United 1820– arising near Schuylkill 68 [ambiguous] States 1823 River fever 69 Spain 1821 Barcelona yellow fever New South 70 Wales, 1828 amongst the Aborigines smallpox Australia 71 Netherlands 1829 Groningen epidemic malaria South 72 1829 smallpox Australia 1829– 73 Iran bubonic plague 1835 Asia, Europe, 1829– 74 >>100,000 second cholera pandemic cholera North 1851 America 75 Egypt 1831 cholera Plains 1831– 76 smallpox Indians 1834 England, 77 1832 London, Paris cholera France North New York City, 78 1832 cholera America Montreal other cities United 79 1833 Columbus, Ohio cholera States United 80 1834 New York City cholera States 1834– 81 Egypt bubonic plague 1836 United 82 1837 Philadelphia typhus States 1837– 1837-38 smallpox 83 Great Plains smallpox 1838 epidemic 84 Dalmatia 1840 plague South 85 1840 Cape Town smallpox Africa United especially severe in the 86 1841 yellow fever States South 1847– 87 20,000+ Canada Typhus epidemic of 1847 epidemic typhus 1848 United 88 1847 New Orleans yellow fever States 1847– 89 worldwide influenza 1848 90 Egypt 1848 cholera North 1848– 91 cholera America 1849 United 92 1850 yellow fever States North 1850– 93 influenza America 1851 United Illinois, the Great Plains, 94 1851 cholera States and Missouri United 95 1852 New Orleans yellow fever States 1852– 96 1,000,000 Russia third cholera pandemic cholera 1860 Ottoman 97 1853 what is now Yemen plague Empire Broad Street cholera 98 616 England 1854 cholera outbreak United 99 1855 yellow fever States 1855– 100 worldwide Third Pandemic bubonic plague 1950 101 Portugal 1857 Lisbon yellow fever Victoria, 102 1857 smallpox Australia Europe, North 1857– 103 America, influenza 1859 South America 1863– 104 Middle East fourth cholera pandemic cholera 1879 105 Egypt 1865 cholera Russia, 1866– 106 cholera Germany 1867 107 Australia 1867 Sydney measles 108 Iraq 1867 plague 1852– 109 Argentina Buenos Aires yellow fever 1871 1870– 110 Germany smallpox 1871 111 40,000 Fiji 1875 Fiji measles Russian Baku, now part of 112 1877 plague Empire Azerbaijan 113 Egypt 1881 cholera India, 1881– 114 >>9,000 fifth cholera pandemic cholera Germany 1896 115 3,164 Montreal 1885 smallpox 1889– 116 1,000,000 worldwide 1889–1890 flu pandemic influenza 1890 Congo 1896– 117 trypanosomiasis Basin 1906 Europe, 1899– 118 >>800,000 sixth cholera pandemic cholera Asia, Africa 1923 San 1900– 119 113 Third plague pandemic bubonic plague Francisco 1904 120 West Africa 1900 yellow fever 1900– 121 Uganda trypanosomiasis 1920 122 Egypt 1902 cholera 123 India 1903 plague 1910– 124 China Manchuria bubonic plague 1912 1918– 125 75,000,000 worldwide 1918 flu pandemic influenza 1920 1918– 126 Russia typhus 1922 1942– 127 Egypt malaria 1944 128 China 1946 Manchuria bubonic plague 129 Egypt 1946 relapsing fever 130 Egypt 1947 cholera 1957– 131 2,000,000 worldwide Asian flu influenza 1958 1961– seventh cholera 132 worldwide cholera present pandemic 1968– 133 1,000,000 worldwide Hong Kong flu influenza 1969 Staphorst, Elspeet and 134 5 Netherlands 1971 Poliomyelitis Uddel 1972 outbreak of 135 Yugoslavia 1972 smallpox smallpox in Yugoslavia United 1972– 136 London flu influenza States 1973 1974 smallpox epidemic 137 15,000 India 1974 smallpox of India 1981– 138 >30,000,000 worldwide HIV/AIDS pandemic HIV/AIDS present South 139 1990s cholera America 1994 plague epidemic in 140 52 India 1994 plague Surat 141 West Africa 1996 meningitis Central 142 2000 dengue fever America 143 Nigeria 2001 cholera South 144 2001 cholera Africa 2002– 145 775 Asia SARS SARS coronavirus 2003 146 Algeria 2003 plague 147 Afghanistan 2004 leishmaniasis 148 Bangladesh 2004 cholera 149 Indonesia 2004 dengue fever 150 Senegal 2004 cholera 151 Sudan 2004 ebola 152 Mali 2005 yellow fever 2005 dengue outbreak in 153 19 Singapore 2005 dengue fever Singapore 154 Angola 2006 Luanda cholera 155 Congo 2006 Ituri Province plague 156 India 2006 malaria 2006 dengue outbreak in 157 50+ India 2006 dengue fever India 158 India 2006 Chikungunya outbreaks Chikungunya virus 2006 dengue outbreak in 159 50+ Pakistan 2006 dengue fever Pakistan 160 Philippines 2006 dengue fever 161 Congo 2007 Mweka ebola 162 Ethiopia 2007 cholera 163 49 India 2007 cholera 2007 Iraq cholera 164 10 Iraq 2007 cholera outbreak 165 Nigeria 2007 polio Puerto Rico, Dominican 166 2007 dengue fever Republic, Mexico 167 Somalia 2007 cholera 168 Uganda 2007 ebola 169 Vietnam 2007 cholera 170 Brazil 2008 dengue fever 171 Cambodia 2008 dengue fever 172 Chad 2008 cholera 173 China 2008 hand, foot and mouth disease 174 Madagascar 2008 bubonic plague 175 Philippines 2008 dengue fever 176 Vietnam 2008 cholera 2008– 2008–2009 Zimbabwean 177 4,293 Zimbabwe cholera 2009 cholera outbreak 2009 Bolivian dengue 178 18 Bolivia 2009 dengue fever fever epidemic 2009 Gujarat hepatitis 179 India 2009 hepatitis B outbreak Queensland, 180 2009 dengue fever Australia Mumps outbreaks in the 181 worldwide 2009 mumps 2000s 2009– 2009-2010 West African 182 931 West Africa meningitis 2010 meningitis outbreak 2009– 183 14,286 worldwide 2009 flu pandemic influenza 2010 6,500+ 2010– 2010–2011 Haiti cholera 184 (January Hispaniola cholera present outbreak 2012) 2011– 185 Congo measles present 2011– 186 81 Vietnam hand, foot and mouth disease present 2011– 2011 dengue outbreak in 187 350+ Pakistan dengue fever present Pakistan

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Original source : en.wikipedia.org/wiki/List_of_epidemics