Q2 2020 XPEDITE Portfolio Our XPEDITE List Primarily Consists of More Demanding Targets, for Which We Have Established In- House Protocols for Crystallization

Q2 2020 XPEDITE Portfolio Our XPEDITE list primarily consists of more demanding targets, for which we have established in- house protocols for crystallization. In addition, this service grants you quick access to ligand-target protein complex structures, when the crystallization conditions are well described in the literature. XPEDITE service also include the work on disease relevant mutations of established targets and the optimization of published but low resolution structures.

Established and/or published conditions Few hundred disease-relevant targets Average 4 months turn-around

Protein Name UniProt Identifier Protein Name UniProt Identifier

ABCB10 Q9NRK6 AURKA O14965

ACACB O00763 AURKB Q96GD4

ACLY P53396 Barstar P11540

ACVR1B P36896 BAX Q07812

ADORA2A P29274 BAZ1A Q9NRL2

AK1 p00568 BCAT1 P54687

AKT2 P31751 BCL2 P10415

AKT3 Q9Y243 BCL2L1 Q07817

ALK Q9UM73 β-Lactoglobulin P02754

ALPK1 Q96QP1 BirA P06709

ASGR2 P07307 BIRC2 Q13490

ATAD2 Q6PL18 BRDT Q58F21

ATAD2B Q9ULI0 Bromelain P14518

ATM Q13315 BTK Q06187

ATR Q13535 BUB1 O43683

ATRIP Q8WXE1 CAMKK2 Q96RR4

Q2 2020

Protein Name UniProt Identifier Protein Name UniProt Identifier

CANX P27824 CKS2 P33552

Caspase3 P42574 CNR1 P21554

CCM2 Q9BSQ5 Comt P22734

CCM3 Q9BUL8 CRISP-3 O19010

CCNA2 P20248 Csk P32577

CCNC P24863 CTNB1 P35222

CCNH P51946 CTSB P07858

CCNK O75909 CTSC P97821

CD3D P04234 CTSK O35186

CD3E P07766 CTSL1 P07711

CD3G P09693 CUL4A Q13619

CDC37 Q16543 cybC P0ABE7

CDK8 P49336 DBF4 Q9UBU7

CDK8/CycC unknown DDB1 Q16531

CDKL1 Q00532 DDR1 Q08345

CDKL2 Q92772 DDX58 O95786

CDKL5 O76039 dgoT P0AA76

CDT1 Q9H211 DHODH Q02127

CETP P11597 DNAJB1 P25685

CFTR A0M8U4 DNM1L O00429

CHD4 Q14839 DOCK5 Q9H7D0

CHK1 O14757 DOT1L Q8TEK3

CK1_3 Q9Y6M4 DYRK1B Q9Y463

CKS1B P61024 DYRK2 Q92630

Q2 2020

Protein Name UniProt Identifier Protein Name UniProt Identifier

DYRK3 O43781-2 FFAR1 O14842

DYRK4 Q9NR20 FGFR2 P21802

E4PDH P0A9B6 FKBP12 P62942

EED O75530 FKBP5 Q13451

EGLN1 Q9GZT9 Flt-1 P17948

EGLN2 Q96KS0 FNTA P49354

EGLN3 Q9H6Z9 FNTB P49356

EHMT2 Q96KQ7 FURIN P09958

EIF2A Q9BY44 GAK O14976

EIF2AK3 Q9NZJ5 GCGR P47871

EIF2S1 P05198 GFP P42212

ELB P16278-2 GIPR P48546

EME1 Q96AY2 GLB1 P16278

EphA3 P29320 GLI1 P08151

EphA7 Q15375 GNAS P63092

EPHB1 P54762 GP6 A0A2K5VXN2

EphB4 P54760 Grap2 O89100

EXO1 Q9UQ84 GRM1 Q13255

EZH2 Q15910 GRM5 P41594

F3 P13726 GRM7 Q14831

F8 P00451 GSK3A P49840

FBXO17 Q96EF6 HAT1 O14929

FER P16591-2 HCK P08631

FES P07332 HDAC-1 Q13547

Q2 2020

Protein Name UniProt Identifier Protein Name UniProt Identifier

HDAC-10 Q969S8 JMJD1A Q9Y4C1

HDAC-6 Q9UBN7 JMJD2E B2RXH2

HPGD P15428 JMJD6 Q6NYC1

HRAS P01112 KDM8 Q8N371

HRV-B H9EHM4 KHDRBS1 Q07666

HRV-C G8IJF5 KHDRBS2 Q5VWX1

HS2ST1 Q7LGA3 KSR1 Q8IVT5

HSPA5_m P20029 KSR2 Q6VAB6

HUS1 O60921 L3MBTL1 Q9Y468

IDH2 P48735 L3MBTL2 Q969R5

IFIH1 Q9BYX4 L3MBTL3 Q96JM7

IKK2 O14920 Lamtor2 Q9JHS3

IL17A Q16552 LDHA P00338

IL18R1 Q13478 LIG1 P18858

IL18RAP O95256 LIG3 P49916

IL1RL1 Q01638 LIMK1 P53667

IL2 P60568 Lipolase unknown

IL2RA P01589 LLC P03772

IL2RB P14784 LPXC_ECOLI P0A725

IL2RG P31785 LPXC_NEIG1 Q5F569

IL7R P16871 LPXC_PSEAE P47205

IRF4 Q15306 LRRK2 Q5S007

ITGAV P06756 MAOB P19643

ITGB1 P05556 Map2K4 P45985

Q2 2020

Protein Name UniProt Identifier Protein Name UniProt Identifier

MAP2K5 Q13163 NR4A1 P22736

Map2K7 O14733 NR5A2 O00482

MAP3K14 Q99558 NRDP1 Q9H4P4

MAP3K5 Q99683 NTRK3 Q16288

MAP4K4 O95819 NTSR1 P30989

MapK13 Q9Z1B7 P2RX3 P56373

MAX P61244 PADI2 Q9Y2J8

MBD3 O95983 PAK1 Q13153

MDM2 Q00987 PAK6 Q9NQU5

MELK Q14680 PAK7 Q9P286

MKNK1 Q9BUB5 Parp-12 Q9H0J9

MLST8 Q9BVC4 Parp-14 Q460N5

MTA1 Q13330 Parp-15 Q460N3

MUS81 Q96NY9 Parp-3 Q9Y6F1

MYD88 Q99836 PAS Q96RG2

MYST1 Q9H7Z6 PBRM1 Q86U86

NEDD4 P46934 PC P11498

NEK7 Q8TDX7 PDE3B Q13370

NFKB1 P19838 PDE6D O43924

NLRP3 Q96P20 PDK1 Q15118

NMT1 P30419 PDK2 Q15119

NO66 Q9H6W3 PDK3 Q15120

NOD2 Q9HC29 PDK4 Q16654

NR2F6 P10588 PDPK1 O15530

Q2 2020

Protein Name UniProt Identifier Protein Name UniProt Identifier

PF3D7_0515300 Q8I3V5 PRKAG2 Q9UGJ0

PF4 A0A2K5V1A0 PRKAG3 Q9UGI9

PGGT1B P53609 PRMT3 O60678

PHKG2 P15735 PRMT5 O14744

PIK3CD O00329 PTK2B Q14289

PIK3R1 P27986 PTK6 Q13882

PKCtheta Q04759 PYGL P06737

PKM2 P14618 QPCTL Q9NXS2

PKMYT1A Q99640 RAC1 P63000

PLA2G16 P53816 RAD1 O60671

Plk-1 Q4KMI8 RAD9A Q99638

Plk-4 O00444 RAF1 P04049

POLQ O75417 RARA P10276

PPARA Q07869 RBBP4 Q09028

PPARD Q03181 RBBP7 Q16576

PPARG P37231 RBX1 P62877

PPID Q08752 RCOR1 Q9UKL0

PPP1CA P62136 REL Q04864

PPP2R1A P30153 RIPK1 Q13546

PPP5C P53041 RIPK2 O43353

PRDM10 Q9NQV6 Ron Q04912

PRKAB1 Q9Y478 RORA P35398

PRKAB2 O43741 RORB Q92753

PRKAG1 P54619 RSK2 P51812

Q2 2020

Protein Name UniProt Identifier Protein Name UniProt Identifier

RTF1 Q92541 STAT3 P40763

Rub P24297 STK33 Q9BYT3

RXRA P19793 STK4 Q13043

SARM1 Q6SZW1 STY8 O22558

SB11 Q46731 Subtilisin P00780

SGK1 O00141 SUI2 P20459

SH2D1A O60880 TAF1L Q8IZX4

SIK2 Q9H0K1 TASP1 Q9H6P5

SIRT1 Q96EB6 TBK1 Q9UHD2

SIRT5 Q9NXA8 TCEB1 Q15369

SIRT7 Q9NRC8 TCEB2 Q15370

SKP1 P63208 TET1 Q8NFU7

SLC2A1 P11166 TET2 Q6N021

SMARCA1 P28370 TET3 O43151-4

SMARCA5 O60264 THRA P10827

SMARCA6 Q9NRZ9 THRB P10828

SMARCC1 Q92922 TKTL1 Q99MX0

SMARCC2 Q8TAQ2 TKTL2 Q9H0I9

SMYD2 Q9NRG4 TLR3 O15455

SMYD3 Q9H7B4 TLR7 Q9NYK1

SND Q5FPV1 TLX Q9Y466

SNRPC P09234 Tmem173 Q3TBT3-3

SOS1 Q07889 TNF P01375

SPSB4 Q96A44 TNFRSF9 Q07011

Q2 2020

Protein Name UniProt Identifier Protein Name UniProt Identifier

TNKS2 Q9H2K2 USP2 O75604

TOPBP1 Q92547 USP8 P40818

TP53 P04637 VEGF-R2 P35968

TREM2 Q9NZC2 VHL P40337

TUBA1B P81947 VP0 Q82122

TUBB2B Q6B856 WDR48 Q8TAF3

TYR P14679 WDR77 Q9BQA1

UBB P0CG47 WHSC1L1 Q9BZ95

ULK1 O75385 WRN Q14191

ULK2 Q8IYT8 XRN1 Q8IZH2

ULK3 Q6PHR2 ZC3H12A Q5D1E8

USP19 O94966