Towards An HTA Ecosystem: From Local Needs To Global Opportunities Thank You to All Our Sponsors PLATINUM UNIVERSITÀ CATTOLICA del Sacro Cuore ALTA SCUOLA DI ECONOMIA E MANAGEMENT DEI SISTEMI SANITARI GOLD SILVER Contents Welcome 4 President’s Welcome 5 Minister of Health’s Welcome 6 Greetings From the Rome 2017 Local Organising Committee 8 International Scientific Programme Committee (ISPC) Co-Chairs’ Message 9 Rome 2017 Local Organizing Committee 10 International Scientific Program Committee (ISPC) 11 About HTAi 13 HTAi Board of Directors 2016-2017 15 Interest Groups 16 Policy Forums 18 Partnerships 19 HTAi Secretariat 20 General Information 21 General Information 23 Program 35 Pre-Meeting Workshops 40 Feature Sessions 52 Panels 72 Oral Presentations 93 Vignettes 117 HTAi Interest Group Meetings 150 HTAi and Associated Meetings 152 Sponsor Events and Symposia 155 Posters 163 Posters 165 Sponsors / Exhibitors 205 Platinum Sponsors 207 Gold Sponsors 213 Silver Sponsors 215 Symposia Sponsors 216 Exhibitors 217 Other Contributions 220 Exhibit Floor Plans 221 Notes 224 WELCOME Welcome Benvenuti a Roma! Welcome HTA is now evolving towards an to Rome, and to HTAi 2017 — integrated network or “ecosystem” Towards an HTA Ecosystem: where local needs can be addressed. This new ecosystem is shaped by both From Local Needs to Global old and new forms of cooperation, Opportunities and builds on the groundbreaking We are pleased to be hosting our global global collaboration proposed by the members in what promises to be a International Network of Agencies stimulating and very current meeting for Health Technology Assessment that focuses on the production and (INAHTA) in 1993. For example, by implementation of HTA and how best to 2019, the European Network for Health impact health care decision-making at Technology Assessment (EUnetHTA) the global level. We encourage you to is expected to sustain its own HTA enjoy the ambience of Rome and take system that is fully integrated within advantage of everything this historical the European regulatory framework city has to offer, while being an active for drugs and medical devices. In the participant in this annual gathering of the Americas, the Regional Network of global HTA community. Health Technology Assessments for the Americas (RedETSA) is proposing a new THE THEME OF OUR CONFERENCE model for collaboration and, similarly, Asian countries have started a new HTA is considered an effective approach network through HTAsiaLink. Many other to governing health systems, managing examples have been reported worldwide. innovation, and informing decision- making at national and regional levels. We hope the HTAi 2017 Annual Meeting International collaborations, national and will contribute to generating many regional HTA bodies, and hospital-based discussions on this ecosystem approach HTA units or functions all contribute to and propelling it beyond national borders a sustainable health care network — one towards a more inclusive, international that requires coordination to improve model that helps facilitate health care clinical and organisational processes and decision-making at the global level. patient outcomes. 4 PRESIDENT’S WELCOME President’s Welcome meeting over the past two years, in particular On behalf of the HTAi Board of the International Directors, I would like to extend a Scientific Programme hearty “Buongiorno e benvenuti!” to Committee Chairs the HTAi Annual Meeting 2017. Rabia Kahveci and Americo Cicchetti, all of We are delighted that this year’s the Committee members, as representatives — who hail from more well as the Local Organising Committee. than 59 countries — have joined us in Without their support, and that of others Rome, Italy, a country well-established in the HTA community, HTAi would cease in HTA. to function. The dedication of our many members is a wonderful testament to These next five days provide a unique our community and to the collaborative opportunity in which to contribute to global effort to improve health care. the development of our field. While Rome is enchanting, and we encourage One example of this dedication is the you to enjoy the many facets of the work of our 10 Interest Groups, which are city, we also hope you maximize your holding their own annual meetings here time here and attend the progressive in Rome. I encourage you to attend their plenary sessions and diverse array of meetings, connect with other members, panels and workshops, oral and poster or visit the HTAi booth for more details. presentations, and this year’s new introduction of vignettes. Make sure to Rome is an energetic, vibrant city, and we also seize the opportunity to network hope that HTAi 2017 reflects this vibrancy by seeking out members with similar in lively and energetic discussions. It’s interests or divergent opinions. You your opportunity to make it happen, so never know what might lead to future “Andiamo!” Let’s go! collaborations or have a positive impact on your own work. Professor Guy Maddern, Australia President, HTAi I would like to thank the volunteers who contributed to the planning of this 5 MINISTER OF HEALTH’S WELCOME the Regional Health Minister of Health’s Authorities under a Welcome unique framework that was developed Message From the Minister of thanks to the joint Health, the Honourable participation of major Beatrice Lorenzin stakeholders. Health care systems worldwide are But this is just the first step. In 2016, the facing major challenges as they try Italian government created, in the Fiscal to guarantee timely patient access to Law for 2016, a national commission valuable technological innovations tasked with reviewing and updating while, at the same time, ensuring the “LEAs” (Livelli Essenziali di Assistenza) sustainability of economic and social — the core health benefits and services systems. These challenges are shaping provided by the Italian National Health the future of health care systems Service — to ensure they are appropriate internationally, and it is becoming more and current. and more evident that the best way to approach them is to rely on HTA. Indeed, this review process will make good use of HTA methods and tools to The Government of Italy and my Ministry, inform decision-making and make HTA in particular, are making substantial affordable, accepted, and sustainable. investments in the implementation of a Our final objective is to define a formal National Programme for HTA (NaPHTA). process for introducing services within LEAs and for making selective Recent legislation established a National disinvestments, if needed, based on the Coordinating Office for HTA (NCOHTA) at founding principles of HTA. the Ministry of Health, which collaborates with the Agenzia per i Servizi Sanitari Hosting HTAi’s 14th Annual Meeting Regionali (AGENAS, the National provides an opportunity to present the Agency for Regional Health Services), new NaPHTA that is currently being the Agenzia Italiana del Farmaco (AIFA, implemented – the first concrete the Italian Medicines Agency), and result in a journey that began with the 6 MINISTER OF HEALTH’S WELCOME achievements of the NaPHTA Working Group. The NaPHTA is built into the new EU HTA Network, which, I am proud to say, was guided by our Italian team. Indeed, I am very proud of what has already been achieved. I hope this important meeting will foster international collaboration between Italy and other countries — European and non-European alike — aimed at achieving the challenging objective identified recently in Malta: to make drug innovation sustainable and accessible through pricing negotiation for innovative drugs, and with the active cooperation of the HTA community. We are committed to maintaining our universal health care system while ensuring a sustainable future, and we strongly believe the right way forward will depend on the development of genuine global collaboration among open-minded stakeholders. The Honourable Beatrice Lorenzin, Minister of Health, Italy 7 GREETINGS FROM THE ROME 2017 LOCAL ORGANISING COMMITTEE Greetings From the Rome 2017 Local Organising Committee Cari amici, dear friends, has made with the help of the scientific community and the support of the On behalf of the Local Organising National Health Service’s national and Committee, it is my great honour and regional institutions and hospitals, pleasure to welcome you to Rome patients’ and citizens’ groups, and for the 14th Annual Meeting of Health industry. Technology Assessment international (HTAi). Thanks to the initiative of the We are convinced that the 2017 HTAi Società Italiana di Health Technology Annual Meeting will be a unique Assessment (SIHTA), the “Eternal City” is opportunity to foster discussion and hosting for the second time since 2005. collaboration among different scientific domains, stakeholders, and institutional Italy, and Rome in particular, have levels. Such collaboration is vital for provided a fruitful environment for creating an effective HTA ecosystem establishing a dynamic HTAi scientific needed to meet the challenge of network, culminating in this annual providing timely and comprehensive meeting thanks to a very broad and health care for all that is both sustainable representative Local Organising and respectful of human dignity. Committee. Since 2005, Italy has pioneered hospital-based HTA, and HTA Enjoy your stay with us in Roma! is now at the forefront of the country’s health policy agenda, as evidenced by Professor Americo Cicchetti, Italy the endorsement of SIHTA by Italian President and