Preliminary Program

ICBS2014 Driving Biology with Chemistry 3rd Annual Conference of the International Society

November 17 – 19, 2014 InterContinental San Francisco San Francisco, CA, USA

www.chemical-biology.org ICBS2014 — Preliminary Program

ICBS Board of Directors About ICBS Masatoshi Hagiwara, President Melvin Reichman, President-Elect ICBS Mission Statement Petr Bartůnĕk, Secretary Jonathan Baell, Membership The International Chemical Margaret Johns, Treasurer Biology Society (ICBS) is Rathnam Chaguturu an independent, nonprofit Haian Fu, Past President Krishna Kodukula organization dedicated to Lixin Zhang promoting research and educational opportunities at International Advisory Board the interface of chemistry and Stephen Benkovic, Penn State biology. ICBS provides an Sir Philip Cohen, University of Dundee important international forum that Jian Ding, Shanghai Institute of Materia Medica brings together cross-disciplinary Chris Lipinski, Melior Discovery Bernard Munos, InnoThink scientists from academia, Ferid Murad, George Washington University nonprofit organizations, Tetsuo Nagano, University of Tokyo government, and industry to , Harvard Paul Workman, ICR-London communicate new research Litao Zhang, Bristol-Myers Squibb and help translate the power of Leonard Zon, HHMI/Harvard chemical biology to advance human health. ICBS2014 US Organizing Committee Jim Wells, University of California San Francisco (Chair) Haian Fu, Emory University (Co-chair) Doug Auld, Novartis Institutes for Biomedical Research Hakim Djaballah, Memorial Sloan Kettering Cancer Center Kevan Shokat, University of California San Francisco Michael Varney, Genentech

ICBS2014 International Advisory Committee Masatoshi Hagiwara, Kyoto University, Japan (Chair) Melvin Reichman, LIMR Chemical Genomics Center, USA (Co-chair) Jonathan Baell, Monash University, Australia Petr Bartůnĕk, Institute of Molecular Genetics, Czech Republic Rathnam Chaguturu, SRI, USA Siddhartha Roy, CSIR-Indian Institute of Chemical Biology, India Lixin Zhang, Chinese Academy of Sciences, China

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Why Attend the 3rd Annual Conference of the “ICBS represents International Chemical Biology Society? a unique forum Join chemical biologists, drug discovery scientists and professionals from academia, nonprofits, government and industry. for scientists • Engage with attendees from around the globe on innovative topics across the world • Network with thought leaders in chemical biology through formal and informal events to share ideas, • Enjoy opportunities for scientific collaboration, exchange of knowledge and professional development drive innovation • Explore and learn from podium presentations, poster sessions and briefings and implement • Find out about new technologies and resources to support your research from exhibitors and sponsors solutions in the interface of biology

Find out who will receive the ICBS Young Chemical Biology and chemistry, Award — young investigators who make ground-breaking contributions to chemical biology will be recognized. the next wave of life science.”

— Litao Zhang, Bristol-Myers Squibb

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Agenda at a Glance

Monday, November 17, 2014 9:00 – 9:15 a.m. Welcome 9:15 – 10:00 a.m. Keynote I 10:00 – 10:15 a.m. Refreshment Break with Exhibitors 10:15 – 11:50 a.m. Session I: Chemical Probing of the Ubiquitin Proteasome System 11:50 a.m. – 1:15 p.m. Lunch on own 1:15 – 2:45 p.m. Session II: Probing Protein Homeostasis & Chaperones 2:45 – 4:20 p.m. Session III: Tools for Epigenetics 4:20 – 4:30 p.m. Refreshment Break with Exhibitors 4:30 – 6:05 p.m. Session IV: Identifying and Probing Protein Targets with Chemical Approaches Sponsored by

6:05 – 7:00 p.m. Poster Briefing I 7:00 – 8:30 p.m. Opening Mixer, Exhibitor and Poster Reception I

Tuesday, November 18, 2014 8:00 – 9:30 a.m. Session V: Engineering Biology with Synthetic & Unnatural Proteins 9:30 – 9:45 a.m. Refreshment Break with Exhibitors 9:45 – 11:15 a.m. Session VI: Controlling Cell Fate, Models & Systems Biology 11:15 a.m. – 12:00 p.m. Keynote II 12:00 – 1:30 p.m. Lunch on own 1:30 – 3:00 p.m. Session VII: Central Nervous System & Neurobiology 3:00 – 3:15 p.m. Refreshment Break with Exhibitors 3:15 – 5:20 p.m. Session VIII: Perturbing & Observing Biology in Living Cells 5:20 – 6:20 p.m. Poster Briefing II 6:20 – 7:30 p.m. Exhibitors and Poster Reception II

Wednesday, November 19, 2014 8:00 – 9:40 a.m. Session IX: Tackling Challenging Diseases 9:40 – 9:55 a.m. Refreshment Break with Exhibitors 9:55 – 11:35 a.m. Session X: Novel Chemistry for Discovery 11:35 a.m. – 1:05 p.m. Lunch on own 1:05 – 2:30 p.m. Session XI: Natural Product & Synthetic Biology 2:30 – 3:30 p.m. Special Session: Rising Stars of Chemical Biology 3:30 – 4:00 p.m. ICBS Annual Business Meeting 4:00 – 5:20 p.m. Session XII: Reproducibility & Transparency in Biomedical Research 5:20 – 6:05 p.m. Keynote III 6:05 – 6:35 p.m. Closing Remarks 4 Visit www.chemical-biology.org for the latest conference information. ICBS2014 — Preliminary Program

THANK YOU TO OUR SPONSORS

Exhibitor and Sponsorship Opportunities The International Chemical Biology Society invites Researchers need your cutting-edge tools and services you to participate in the 3rd Annual Conference in San to realize their potential in the lab. Meet face-to-face with Francisco, California. Chemical and biology professionals the experts in chemical biology and help them realize that from industry, academia, nonprofit organizations and potential. government will join together from around the world to promote the collaboration and exchange of important To become an ICBS2014 conference sponsor or innovative research to accelerate the development of exhibitor, contact Madhuri Carson at +1-847-753-5217 or intervention strategies for better health. [email protected].

As a sponsor or exhibitor of the ICBS2014 3rd Annual Conference you will benefit from excellent exposure and acknowledgement through ads, signs, website links and conference admission, depending on your package. Get your products and services in front of this growing audience of experts, directly support the research goals and education of chemical biologists worldwide and build valuable contacts.

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Keynote Speakers Kevan Shokat, University of California, San Francisco Modulating Signaling via Polypharmacology of Kinases and RAS

Kevan Shokat is an Investigator at the Howard Hughes Medical Institute, chair of the Department of Cellular and Molecular Pharmacology at the University of California at San Francisco. He is also a professor in the Department of Chemistry at the University of California at Berkeley. After receiving his PhD in organic chemistry at University of California at Berkeley with Professor Peter Schultz, and post-doctoral work in immunology at Stanford University with Professor Chris Goodnow, Dr. Shokat began his independent research career at Princeton. He has received numerous awards including being named a fellow of several prestigious research foundations including the Pew Foundation, Searle Foundation, Sloan Foundation, Glaxo-Wellcome Foundation, and the Cotrell Foundation. He has also received the Eli Lilly Award. He was inducted into the National Academy of Sciences (2010), the Institute of Medicine (2011), and the American Academy of Arts and Sciences (2011). He has focused on the development of chemical methods for investigating cellular signal transduction pathways—with a particular focus on protein kinases and lipid kinases. Dr. Shokat uses a combination of chemical synthesis and protein engineering to create uniquely traceable and regulatable kinases, allowing the function of over 100 different kinases to be uncovered across all disease areas including oncology, metabolism, and infectious disease.

Zixin Deng, Shanghai Jiaotong University Synthetic Microbiology for Natural Products and Fine Chemicals Zixin Deng is a professor of microbiology, dean of the Shanghai Jiaotong University School of Life Sciences & Biotechnology and Wuhan University School of Pharmaceutical Sciences, and the head of the National Key Laboratory of Microbial Metabolism. He is also the current president of Chinese Society of Microbiology. He is a member of the Chinese Academy of Sciences, a Fellow of the Science Academy for the Developing World (formally the Third World Academy of Sciences, TWAS), and a Fellow of the American Academy of Microbiology. Dr. Deng received his BS in microbiology from Huazhong Agricultural University and PhD in microbial genetics from the University of East Anglia, UK. He worked in the streptomyces group at John Innes Centre. Dr. Deng’s areas of interest include streptomyces genetics, biochemistry and molecular biology of antibiotic biosynthesis, and DNA backbone modification by sulfur (phosphorothiolation).

Giulio Superti-Furga, Austria Academy of Sciences Systems Chemical Biology of Drug Action and Drug Transport Giulio Superti-Furga directs the CeMM Research Center for Molecular Medicine for the Austrian Academy of Sciences in Vienna, Austria. His work includes the elucidation of basic regulatory mechanisms of tyrosine kinases in human cancers, the discovery of fundamental organization principles of the proteome of higher organisms and the development of integrated approaches to understand the mechanism of action of drugs at the molecular level. Most recently he has focused on studying and understanding the time-resolved molecular impact of perturbations, such as drugs or viruses, on the human system. He is a member of: EMBO, Austrian Academy of Sciences, German Academy of Sciences, European Academy of Cancer Sciences and chair of the EMBL Alumni Association. Dr. Superti-Furga studied molecular biology at the University Zurich, Genentech, and IMP/Vienna in the laboratory of Meinrad Busslinger. He was a post-doctoral fellow with Giulio Draetta and Sara Courtneidge at the EMBL and later became an EMBL Team Leader. He also co-founded the companies Cellzome and Haplogen.

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Preliminary Schedule and Speakers Monday, November 17, 2014 Danica Fujimori, University of California, San Francisco Morning Chromatin-Mediated Regulation of Histone Opening Remarks Demethylases

Keynote I Jolanta Grembecka, University of Michigan Development of Small Molecule Menin-MLL Inhibitors Zixin Deng, Shanghai Jiaotong University for Epigenetic Regulation in Cancer Synthetic Microbiology for Natural Products and Fine Chemicals Kyle Konze, University of North Carolina, Chapel Hill Design, Development, and Functionalization of Chemical Session I: Chemical probing of the Ubiquitin Probes for the Lysine Methyltransferases EZH2 and G9a Proteasome System

Raymond Deshaies, California Institute of Technology Session IV: Identifying and Probing Protein Targets Is Induction of Proteotoxic Crisis a Broadly Applicable with Chemical Approaches Approach to Therapy of Cancer? Sponsored by: Eric Strieter, University of Wisconsin, Madison Debranching Ubiquitin Chains with Ubiquitin C-Terminal Hydrolases Ben Cravatt, The Scripps Research Institute Kamyar Hadian, Helmholtz Center Munich Activity-based Proteomics – Applications for Enzyme Targeting Protein-Protein Interactions in the Ubiquitin- and Inhibitor Discovery Proteasome System Thomas J. Wandless, Stanford University Monica Schenone, Broad Institute of MIT and Harvard A Chemical Biology Approach to Understanding Protein University Quality Control Surveillance Mechanisms in Eukaryotic Lenalidomide Promotes CRBN-mediated Ubiquitination Cells and Degradation of IKZF1 and IKZF3 Vladimir Chupakhin, Janssen Pharmaceuticals, Inc., a pharmaceutical company of Johnson & Johnson, Spain Afternoon From Computational Chemogenomics to Target Deconvolution of Phenotypic Screens Session II: Probing Protein Homeostasis & Chaperones Jeff Kelly, The Scripps Research Institute Xin Zhang, The Scripps Research Institute The Hsp70-40-Nucleotide Exchange Factor Folding Small Molecule Probes to Quantify the Functional Pathway Hastens Transthyretin Folding and Alters the Fraction of a Specific Protein in a Cell with Minimal Resulting Structure Rendering it Kinetically More Stable Folding Equilibrium Shifts

Jason Gestwicki, University of California, San Francisco Targeting Protein-Protein Interactions in the Heat Shock Opening Mixer, Exhibitors and Poster Reception I Protein 70 (Hsp70) Complex

Session III: Tools for Epigenetics Cheryl Arrowsmith, University of Toronto Chemical Probes to Antagonize Readers and Writers Driving Biology Methyl Marks with Chemistry

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Preliminary Schedule and Speakers Tuesday, November 18, 2014 Afternoon Morning Session VII: Central Nervous System & Neurobiology Session V: Engineering Biology with Synthetic & Scott Sternson, Janelia, Howard Hughes Medical Institute Unnatural Proteins Chemical Biology of Ligand-Gated Ion Channels for David Lawrence, University of North Carolina, Chapel Hill Causal Neuroscience Illuminating the Path for Drug Delivery Marie-Laure Vial, Eskitis Institute for Drug Discovery- Gloria Andolina, University of Zurich Griffith University Labeling the Bacterial Outer Membrane Transporter An Unbiased Multidimensional Profiling Method to Study LptD Using an Antimicrobial Peptide by Chemical the Biology of Parkinson’s disease Cross-linking.

Hiroshi Sugiyama, Kyoto University Session VIII: Perturbing & Observing Biology in Living Cells Chemical Biology that Controls DNA Structure and Function: DNA Origami and Artificial Genetic Switch Peng Chen, Peking University Deprotection chemistry-mediated protein activation in Janet McCombs, University of Texas Southwestern living cells Medical Center Pneumococcal Neuraminidase Substrates Identified Michiyuki Matsuda, Kyoto University Through Chemoenzymatic Labeling Long-term Activity Imaging in Cells and Mice by Transposon-mediated Stable-expression of FRET Biosensors. Session VI: Controlling Cell Fate, Models, & Systems Biology Liam Cox, University of Birmingham, UK Sheng Ding, Gladstone Institute of Cardiovascular New Chemical Probes for Imaging Glycolipid Trafficking Disease Arnaud Gautier, Ecole Normale Superieure France A Chemical Approach to Controlling Cell Fate Small fluorogen-activating Protein Tags for Protein Evripidis Gavathiotis, Albert Einstein College of Medicine Imaging in Living Cells Small-molecule Modulation of Apoptosis via Direct Kenjiro Hanaoka, The University of Tokyo Targeting of Pro-apoptotic BAX Development of a Red Fluorescence Probe for Richard Hartley, University of Glasgow Monitoring Dynamics of Cytoplasmic Calcium Ion Targeting Sensors and Molecular Probes: Oxidative Shin-nosuke Uno, The University of Tokyo Stress and Aging A Spontaneously Blinking Fluorophore Based on Keynote II Intramolecular Spirocyclization for Live-cell Super-resolution Imaging Kevan Shokat, University of California, San Francisco Modulating Signaling via Polypharmacology of Kinases and RAS Exhibitors and Poster Reception II

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Preliminary Schedule and Speakers Wednesday, November 19, 2014 Morning Afternoon Session XI: Natural Product and Synthetic Biology Session IX: Tackling Challenging Diseases Jianhua Ju, South China Sea Institute of Oceanology Mike Varney, Genentech Anti-infective and Anti-tumor Natural Products The Discovery and Early Development of the PI3K Discovery and Biosynthesis from marine Actinomycetes Inhibitor GDC-0032 Gopinatha Suresh Kumar, CSIR Indian Institute of Rajesh Gokhale, CSIR-Institute of Genomics & Integrative Chemical Biology Biology of India Unique RNA Binding Properties of Some DNA Binding To be announced. Naturalalkaloids

Haim Barr, Weizmann Institute of Science Xiaoqian Chen, Tongji Medical College, Huazhong Targeted Small Molecule Inhibitors of Synaptojanin 2 University of Science and Technology Activity in Metastatic Breast Cancer Anti-cancer effects and mechanisms of piperlongumine Laurence Lafanechère, CNRS Institut Albert Bonniot in brain and liver tumors INSERM U823, France Ronald Quinn, Eskitis Institute for Drug Discovery, Griffith A Chemical Biology Approach Identified a New Inhibitor University of LIM Kinases Fragment-Based FTMS Screening of a Unique Natural Session X: Novel Chemistry for Discovery Product Library David Fairlie, University of Queensland Special Session: Rising Stars of Chemical Biology Heterocycles as Tuning Forks to Modulate Cell Signaling Session XII: Reproducibility & Transparency in Rami Hanoush, Genentech Biomedical Research Chemical Tools for Imaging Cellular Fatty Acylation David Vaux, Walter & Eliza Hall Institute of Medical Research Jordi Bertran-Vicente, Leibniz-Institut für Molekulare Reproducible Research - What should you Look for, and Pharmakologie (FMP) of Germany Who Can you Trust? A Chemoselective Tool for Lys-phosphorylation Hakim Djaballah, Memorial Sloan Kettering Cancer Martin Witte, University of Groningen, The Netherlands Center Targeted-diazotransfer Reagents to Site-selectively Data Reproducibility in the Post Genomics Era: Death of Introduce Azides on Proteins a Noble Technology

Ronald Frank, FMP - Leibniz-Institut fur Molekulare Pharmakologie A European Research Infrastructure for Chemical Biology, EU-OPENSCREEN

Keynote III Giulio Superti-Furga, Austria Academy of Sciences Systems Chemical Biology of Drug Action and Drug Transport

Closing Remarks

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Interactive Networking Events “A great opportunity

Monday Night Opening Mixer, Exhibitors and Poster to communicate Reception I with chemical biology Enjoy an evening connecting with colleagues in a casual setting. Plus, hear from students and postdoctoral candidates who will share their new chemical researchers.” biology research findings in energized one minute podium presentations. — ICBS2013 Tuesday Night Exhibitors and Poster Reception II Conference Attendee Students and postdoctoral candidates will share their new chemical biology research findings in energized one minute podium presentations.

Business Meeting The ICBS Annual Business Meeting will address routine ICBS Business, including board member elections, treasury reports and other important Society business. Participants will have a chance to ask questions or provide statements.

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Exchange • Connect with world renowned scientists • Learn from passionate leaders in the field of chemistry and biology Growth • Professional networking opportunities • Strengthen research collaboration efforts Engage • Interact with international experts at the Annual Conference • Share current research and clinical advances Impact • Drive research • Change the future of scientific discovery

“Congratulations for such Regular an innovative and important $100 undertaking. Bravo!” – Stuart Schreiber, PhD, Director of Chemical Biology, Join Us Early Broad Institute at Harvard and MIT Career $60

“We are creating a truly international forum that brings together cross-disciplinary scientists from academia, Lifetime nonprofit organizations, $1,000 government and industry to communicate new research and help translate the power Retired Student of chemical biology to advance $60 $25 human health.” – Masatoshi Hagiwara ICBS President 2013-2014 www.chemical-biology.org ICBS2014 — Preliminary Program

Hotel and Travel Information Car Rental All educational sessions will take place at the Avis is the preferred car rental service for ICBS2014. InterContinental San Francisco. Conference concludes Click here to make a reservation or call+1-800-331-1600 Wednesday, November 19, 2014, 7:00 p.m. and indicate Avis Worldwide Discount (AWD) number D016894 to receive special pricing. The ICBS negotiated rate is $269 per night for single or double occupancy. Rooms and rates are available 3 days before and 3 days after the conference dates, based on Attire and Climate availability. Rates are subject to state and local fees/taxes Average temperatures in San Francisco in November (which are currently 16.25 percent), rates will be available are 66° Fahrenheit (19° Celsius) for a high, with a low to attendees, based on availability, though October 15, of 47° Fahrenheit (8° Celsius). Attire for the conference 2014. is business casual. Because people have varying sensitivities to temperatures in hotel meeting rooms, bring a sweater or light jacket to wear inside the hotel. Reserve Your Room Today To reserve a room at the discounted rates click here or call the Intercontinental San Francisco at Travel Visa +1-415-616-6500 and mention you are part of the ICBS Travelers coming from qualified countries to the United conference. Note: When booking online you will have to States for tourism or business for 90 days or less may be click on VIEW ROOMS & RATES and enter in your dates; eligible to visit without a visa. For more information visit this will generate the ICBS special rates. www.travel.state.gov/visa.

A credit card guarantee is required to hold your reservation. The hotel will charge the equivalent of one Host Hotel night’s room and tax if cancellation notice is not provided InterContinental San Francisco to the hotel 72 hours prior to the day of arrival. Hotel 888 Howard Street check-in is 3 p.m., and check-out is Noon. Reservations San Francisco, CA 94103 must be made no later than October 15, 2014. After this United States date, discounted rates may not apply. Phone: +1-415-616-6500

Roommate Service For assistance in finding a roommate, contact Brenda Howe, ICBS Conference Administrator. We will send you a list of other registrants looking for a roommate. It is your responsibility to contact someone on the roommate list and make your reservation with the hotel directly. When e-mailing Brenda, please be sure to include arrival and departure dates, your gender, city and country you reside in and smoking preference to be included on the roommate list, to find a suitable match.

Getting to San Francisco San Francisco International Airport (SFO) is located approximately 14 miles from the hotel. The InterContinental San Francisco is roughly 20 minutes from the airport by car. A taxi will cost approximately $40 USD, one way. Airport shuttles are available for between $17 and $19 USD per person each way. BART – Bay Area Rapid Transit – will cost $8.25 for a one way fare.

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